HL7.FHIR.UV.GENOMICS-REPORTING\Example - Full Bundle Oncology Example

This page is part of the Genetic Reporting Implementation Guide (v1.1.0: STU 2 Ballot 1) based on FHIR R4. The current version which supercedes this version is 2.0.0. For a full list of available versions, see the Directory of published versions

Example Bundle: Example - Full Bundle Oncology Example

Bundle oncologyexamples-r4 of type transaction

Entry 1 - Full URL = urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d

Request:

POST Patient

Resource Patient:

Carrot John Mr Male 1962-12-31 ( id: 1007)

Entry 2 - Full URL = urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef

Request:

POST Practitioner

Resource Practitioner:

Generated Narrative
Texts
-
*
identifier: id: 4654765876
name: Akerman Philip Prof
address: Castro Valley CA

Entry 3 - Full URL = urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d

Request:

POST Specimen

Resource Specimen:

Generated Narrative
Texts
-
*
identifier: id: 076e1948-2217-11e9-94d8-12e241dc1f66
status: AVAILABLE
subject: Generated Summary: type: transaction
Collections
- Collector
* Generated Summary: type: transaction

Entry 4 - Full URL = urn:uuid:40e85eda-4d31-4bd2-a5a0-c39d63f9824f

Request:

POST Observation

Resource Observation:

Generated Narrative
Texts
-
*
code: Tumor Mutational Burden
subject: Generated Summary: type: transaction
performer: Generated Summary: type: transaction
value: 25.0 somatic variants per megabase of sequenced DNA
specimen: Generated Summary: type: transaction

Entry 5 - Full URL = urn:uuid:64b91716-6431-41bd-8fd4-7ac99bebdee9

Request:

POST Observation

Resource Observation:

Generated Narrative
Texts
-
*
code: MSI status
subject: Generated Summary: type: transaction
performer: Generated Summary: type: transaction
value: High
specimen: Generated Summary: type: transaction

Entry 6 - Full URL = urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12d

Request:

POST Observation

Resource Observation:

Generated Narrative
Texts
-
*
category: Laboratory
code: Genetic variant assessment
subject: Generated Summary: type: transaction
performer: Generated Summary: type: transaction
value: Present
method: Sequencing
specimen: Generated Summary: type: transaction
component
code: Genomic DNA change (gHGVS)
value: 9:g.5073770G>T
component
code: Amino acid change (pHGVS)
value: p.Val617Phe
component
code: Amino acid change type
value: Missense
component
code: Genomic source class
value: Germline
component
code: Gene studied ID
value: JAK2

Entry 7 - Full URL = urn:uuid:772de7d7-e1bd-4183-bdb5-cea8eda317cd

Request:

POST Observation

Resource Observation:

Generated Narrative
Texts
-
*
category: Laboratory
code: Genetic variant assessment
subject: Generated Summary: type: transaction
performer: Generated Summary: type: transaction
value: Present
method: Sequencing
specimen: Generated Summary: type: transaction
component
code: Genomic DNA change (gHGVS)
value: 4:g.55972974T>A
component
code: Amino acid change (pHGVS)
value: p.Gln472His
component
code: Amino acid change type
value: Missense
component
code: Genomic source class
value: Germline
component
code: Gene studied ID
value: KDR

Entry 8 - Full URL = urn:uuid:b33eb7ec-d83e-49d2-b0f3-729d024ebe01

Request:

POST Observation

Resource Observation:

Generated Narrative
Texts
-
*
category: Laboratory
code: Genetic variant assessment
subject: Generated Summary: type: transaction
performer: Generated Summary: type: transaction
value: Present
method: Sequencing
specimen: Generated Summary: type: transaction
component
code: Genomic DNA change (gHGVS)
value: 2:g.212578380del
component
code: Amino acid change type
value: Missense
component
code: Genomic source class
value: Germline
component
code: Gene studied ID
value: ERBB4

Entry 9 - Full URL = urn:uuid:1bf9642d-fd1c-4819-8c5d-44fae4bad524

Request:

POST Observation

Resource Observation:

Generated Narrative
Texts
-
*
category: Laboratory
code: Therapeutic Implication
subject: Generated Summary: type: transaction
performer: Generated Summary: type: transaction
method: Computational analysis
specimen: Generated Summary: type: transaction
derivedFrom: Generated Summary: type: transaction
component
code: Genetic variation's effect on drug efficacy
value: Responsive
component
code: Level of Evidence
value: Very strong evidence pathogenic
component
code: associated-cancer
value: Polycythemia vera (PV)
component
code: Medication assessed
value: Ruxolitinib

Entry 10 - Full URL = urn:uuid:1301943b-55db-4adf-8355-3635f7268a1b

Request:

POST Observation

Resource Observation:

Generated Narrative
Texts
-
*
category: Laboratory
code: Therapeutic Implication
subject: Generated Summary: type: transaction
performer: Generated Summary: type: transaction
method: Computational analysis
specimen: Generated Summary: type: transaction
derivedFrom: Generated Summary: type: transaction
component
code: Genetic variation's effect on drug efficacy
value: Responsive
component
code: Level of Evidence
value: Very strong evidence pathogenic
component
code: associated-cancer
value: Polycythemia vera (PV)
component
code: Medication assessed
value: AT9283

Entry 11 - Full URL = urn:uuid:05713d1c-0df5-46d5-a5a9-2085eef56c20

Request:

POST Observation

Resource Observation:

Generated Narrative
Texts
-
*
category: Laboratory
code: Therapeutic Implication
subject: Generated Summary: type: transaction
performer: Generated Summary: type: transaction
method: Computational analysis
specimen: Generated Summary: type: transaction
derivedFrom: Generated Summary: type: transaction
component
code: Genetic variation's effect on drug efficacy
value: Responsive
component
code: Level of Evidence
value: Very strong evidence pathogenic
component
code: associated-cancer
value: Polycythemia vera (PV)
component
code: Medication assessed
value: SNX-5422

Entry 12 - Full URL = urn:uuid:294f1401-e2eb-4df1-b6d2-09e1b7a6eca4

Request:

POST Observation

Resource Observation:

Generated Narrative
Texts
-
*
category: Laboratory
code: Therapeutic Implication
subject: Generated Summary: type: transaction
performer: Generated Summary: type: transaction
method: Computational analysis
specimen: Generated Summary: type: transaction
derivedFrom: Generated Summary: type: transaction
component
code: Genetic variation's effect on drug efficacy
value: Responsive
component
code: Level of Evidence
value: Very strong evidence pathogenic
component
code: associated-cancer
value: Polycythemia vera (PV)
component
code: Medication assessed
value: TG02

Entry 13 - Full URL = urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12f

Request:

POST Observation

Resource Observation:

Generated Narrative
Texts
-
*
category: Laboratory
code: grouper
hasMember:
SNV analysis for JAK2 variant. Generated Summary: type: transaction
SNV analysis for KDR variant. Generated Summary: type: transaction
SNV analysis for ERBB4 variant. Generated Summary: type: transaction
TMB value analysis. Generated Summary: type: transaction
MSI status analysis. Generated Summary: type: transaction

Entry 14 - Full URL = urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12e

Request:

POST Observation

Resource Observation:

Generated Narrative
Texts
-
*
category: Laboratory
code: grouper
hasMember:
Therapy match result 1. Generated Summary: type: transaction
Therapy match result 2. Generated Summary: type: transaction
Therapy match result 3. Generated Summary: type: transaction
Therapy match result 4. Generated Summary: type: transaction

Entry 15 - Full URL = urn:uuid:ad7a499b-a43b-4cc8-bf46-cac62d9ecae5

Request:

POST DiagnosticReport

Resource DiagnosticReport:

Exception generating narrative: null