Pharmaceutical Quality (Industry)
1.0.0-ballot - ballot
Pharmaceutical Quality (Industry)
1.0.0-ballot - ballot
This page is part of the Pharmaceutical Quality (Industry) (v1.0.0-ballot: STU1 Ballot 1) based on FHIR (HL7® FHIR® Standard) v5.0.0. . For a full list of available versions, see the Directory of published versions
{
"resourceType" : "Bundle",
"id" : "bundle-product-process-validation-pq-ex3-prod-bio",
"meta" : // Product Process Validation - Biologic
{
"profile" : [
🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Bundle-product-process-validation-pq"
]
},
"type" : "collection",
"entry" : [
{
"fullUrl" : "urn:uuid:2038e4c7-22b8-4c56-2d28-6c077648763f",
"resource" : {
"resourceType" : "PlanDefinition",
"id" : "plandefinition-drug-pq-ex1-validation-protocol",
"text" : // id value="validationProtocol"/
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: PlanDefinition</b><a name=\"plandefinition-drug-pq-ex1-validation-protocol\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource PlanDefinition "plandefinition-drug-pq-ex1-validation-protocol" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f</code></p><p><b>title</b>: DP PROCESS VALIDATION</p><p><b>type</b>: Workflow Definition <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.0.0/CodeSystem-plan-definition-type.html\">PlanDefinitionType</a>#workflow-definition; <a href=\"CodeSystem-cs-planType-local-pq.html\">CodeSystem - Plan Type</a>#process-validation "Process Validation")</span></p><p><b>status</b>: active</p><p><b>subject</b>: <a href=\"#MedicinalProductDefinition_a0694a7a-aafa-4cbe-8135-c788a9a4d3d5\">See above (MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5)</a></p><p><b>description</b>: Pre-defined validation acceptance criteria were established based on manufacturing development data derived from process characterization studies...</p><blockquote><p><b>action</b></p><p><b>title</b>: Formulation Buffer Preparation Process Parameter Step</p><p><b>code</b>: Formulation Buffer Preparation Process Parameter Step <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-manufacturingStep-local-pq.html\">CodeSystem - Manufacturing Step</a>#FormulationBufferPreparationProcessParameterStep)</span></p><blockquote><p><b>action</b></p><p><b>title</b>: Formulation Buffer Preparation Process Parameter Step</p><p><b>code</b>: FormulationBufferPreparationProcessParameterStep <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><blockquote><p><b>action</b></p></blockquote><blockquote><p><b>action</b></p></blockquote><blockquote><p><b>action</b></p></blockquote></blockquote></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: Formulation Buffer Preparation Performance Indicator Results</p><p><b>code</b>: Formulation Buffer Preparation Performance Indicator Results <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-manufacturingStep-local-pq.html\">CodeSystem - Manufacturing Step</a>#FormulationBufferPreparationPerformanceIndicatorStep)</span></p><blockquote><p><b>action</b></p><p><b>title</b>: ???</p><p><b>code</b>: ??? <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><blockquote><p><b>action</b></p></blockquote><blockquote><p><b>action</b></p></blockquote><blockquote><p><b>action</b></p></blockquote><blockquote><p><b>action</b></p></blockquote><blockquote><p><b>action</b></p></blockquote></blockquote></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: Thawing and Formulation Process Parameter Results</p><p><b>code</b>: Thawing and Formulation Process Parameter Resultss <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-manufacturingStep-local-pq.html\">CodeSystem - Manufacturing Step</a>#ThawingandFormulationProcessParameterResultsStep)</span></p><blockquote><p><b>action</b></p><p><b>title</b>: ???</p><p><b>code</b>: ??? <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><blockquote><p><b>action</b></p></blockquote><blockquote><p><b>action</b></p></blockquote><blockquote><p><b>action</b></p></blockquote><blockquote><p><b>action</b></p></blockquote></blockquote></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: Thawing and Formulation Performance Indicator Results</p><p><b>code</b>: Thawing and Formulation Performance Indicator Results <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-manufacturingStep-local-pq.html\">CodeSystem - Manufacturing Step</a>#ThawingandFormulationPerformanceIndicatorResultsStep)</span></p><blockquote><p><b>action</b></p><p><b>title</b>: ???</p><p><b>code</b>: ??? <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><blockquote><p><b>action</b></p></blockquote><blockquote><p><b>action</b></p></blockquote><blockquote><p><b>action</b></p></blockquote><blockquote><p><b>action</b></p></blockquote><blockquote><p><b>action</b></p></blockquote></blockquote></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: Bioburden Reduction Filtration Process Parameter Results</p><p><b>code</b>: Bioburden Reduction Filtration Process Parameter Results <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-manufacturingStep-local-pq.html\">CodeSystem - Manufacturing Step</a>#BioburdenReductionFiltrationProcessParameterResultsStep)</span></p><h3>Actions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><code>ObservationDefinition/74515b3c-5134-448a-9c19-949ce1958434</code></td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: Bioburden Reduction Filtration Performance Indicator Results</p><p><b>code</b>: Bioburden Reduction Filtration Performance Indicator Results <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-manufacturingStep-local-pq.html\">CodeSystem - Manufacturing Step</a>#BioburdenReductionFiltrationPerformanceIndicatorResultsStep)</span></p><h3>Actions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><code>ObservationDefinition/64515b3c-5134-448a-9c19-939ce1958434</code></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><code>ObservationDefinition/75515b3c-5134-448a-9c19-949ce1958434</code></td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: Media Challenge Hold Times</p><p><b>code</b>: Media Challenge Hold Times <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-manufacturingStep-local-pq.html\">CodeSystem - Manufacturing Step</a>#MediaChallengeHoldTimesStep)</span></p><h3>Actions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><code>ObservationDefinition/75515c3c-5134-448a-9c19-949ce1958434</code></td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: Media Challenge Results</p><p><b>code</b>: Media Challenge Results <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-manufacturingStep-local-pq.html\">CodeSystem - Manufacturing Step</a>#MediaChallengeResultsStep)</span></p><h3>Actions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><code>ObservationDefinition/64515b3c-5134-448a-9c19-939ce1958524</code></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><code>ObservationDefinition/64515b3c-5134-448a-9d19-939ce1958524</code></td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: Filtered Formulated Drug Product Performance Indicator Results</p><p><b>code</b>: Filtered Formulated Drug Product Performance Indicator Results <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-manufacturingStep-local-pq.html\">CodeSystem - Manufacturing Step</a>#FilteredFormulatedDrugProductPerformanceIndicatorResultsStep)</span></p><h3>Actions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><code>ObservationDefinition/64525a3d-5034-448a-9c19-938ce1958424</code></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><code>ObservationDefinition/64525a4d-5034-448a-9c19-938ce1958424</code></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><code>ObservationDefinition/64525a33-5034-448a-9c19-938ce1958424</code></td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: Fill Weight Summary</p><p><b>code</b>: Fill Weight Summary <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-manufacturingStep-local-pq.html\">CodeSystem - Manufacturing Step</a>#FillWeightSummaryStep)</span></p><h3>Actions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><code>ObservationDefinition/64515b3c-5134-448a-9c19-939ce2958524</code></td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: Filling Homogeneity Quality Attributes</p><p><b>code</b>: Filling Homogeneity Quality Attributes <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-manufacturingStep-local-pq.html\">CodeSystem - Manufacturing Step</a>#FillingHomogeneityQualityAttributesStep)</span></p><h3>Actions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Conclusion <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><code>ObservationDefinition/22525a3c-5035-448a-9c19-938ce1958424</code></td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: Filling Results Summary</p><p><b>code</b>: Filling Results Summary <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-manufacturingStep-local-pq.html\">CodeSystem - Manufacturing Step</a>#FillingResultsSummaryStep)</span></p><h3>Actions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><code>ObservationDefinition/74515b3c-5134-448a-9c19-939ce1958524</code></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><code>ObservationDefinition/74515b3c-5234-448a-9c19-939ce1958524</code></td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: Statistical Evaluation of Homogeneity Data</p><p><b>code</b>: Statistical Evaluation of Homogeneity Data <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-manufacturingStep-local-pq.html\">CodeSystem - Manufacturing Step</a>#StatisticalEvaluationOfHomogeneityDataStep)</span></p><h3>Actions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><code>ObservationDefinition/74515b3c-5134-448a-9c19-939ce1958534</code></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><code>ObservationDefinition/74515b3c-5234-448a-9c19-939ce1958524</code></td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: Consistency of the Lyophilization Process</p><p><b>code</b>: Consistency of the Lyophilization Process <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-manufacturingStep-local-pq.html\">CodeSystem - Manufacturing Step</a>#ConsistencyoftheLyophilizationProcessStep)</span></p><h3>Actions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><code>ObservationDefinition/fc27b6d6-9fe2-91c2-2d16-47cb5b295e72</code></td></tr><tr><td style=\"display: none\">*</td><td>Definition <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><code>ActivityDefinition/b664977d-799d-a1ce-928a-6def2a9955bd</code></td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: Lyophilization Homogeneity</p><p><b>code</b>: Lyophilization Homogeneity Results <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-manufacturingStep-local-pq.html\">CodeSystem - Manufacturing Step</a>#LyophilizationHomogeneityStep)</span></p><h3>Actions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><code>ObservationDefinition/64525a3d-5134-448a-9c19-938ce1958424</code></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><code>ObservationDefinition/64525a3d-5144-448a-9c19-938ce1958424</code></td></tr></table></blockquote></div>"
},
"url" : "http://example-server.com/fhir/PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f",
"title" : "DP PROCESS VALIDATION",
"type" : // <meta>
<profile value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/PlanDefinition-drug-pq"/>
</meta>
// http://example-server.com/fhir/PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f
{
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/plan-definition-type",
"code" : "workflow-definition",
"display" : "Workflow Definition"
},
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-planType-local-pq",
"code" : "process-validation",
"display" : "Process Validation"
}
]
},
"status" : "active",
"subjectReference" : {
"reference" : "MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5"
},
"description" : "Pre-defined validation acceptance criteria were established based on manufacturing development data derived from process characterization studies...",
"action" : [
// MedicinalProductDefinition/medicinalproductdefinition-drug-product-pq-ex1
{
"title" : "Formulation Buffer Preparation Process Parameter Step",
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStep-local-pq",
"code" : "FormulationBufferPreparationProcessParameterStep",
"display" : "Formulation Buffer Preparation Process Parameter Step"
}
],
"text" : "Formulation Buffer Preparation Process Parameter Step"
},
"action" : [
{
"title" : "Formulation Buffer Preparation Process Parameter Step",
"code" : // this level is not really needed here, could remove. But in the case where there are different timings, it is needed, so it is here for consistency
{
"text" : "FormulationBufferPreparationProcessParameterStep"
},
"action" : [
{
"code" : {
"text" : "Conclusion"
},
"definitionCanonical" : "ObservationDefinition/22515a3c-5034-448a-9c19-938ce1958424"
},
// ObservationDefinition/conclusion
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"
},
// ObservationDefinition/bufferVesselMixingSpeed
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/fc17b5d5-9fe1-91c2-2d06-47cb5b295e73"
}
]
}
]
},
// ObservationDefinition/bufferVesselMixingTime
{
"title" : "Formulation Buffer Preparation Performance Indicator Results",
"code" : // text value="Overall set of actions"/
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStep-local-pq",
"code" : "FormulationBufferPreparationPerformanceIndicatorStep",
"display" : "Formulation Buffer Preparation Performance Indicator Results"
}
]
},
"action" : [
{
"title" : "???",
"code" : {
"text" : "???"
},
"action" : [
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/fc17b5d6-9fe1-91c2-2d16-47cb5b295e72"
},
// ObservationDefinition/FBPPIpH
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/64525a3c-5034-448a-9c19-938ce1958424"
},
// ObservationDefinition/Osmolality
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/64515a3c-5134-448a-9c19-939ce1958424"
},
// ObservationDefinition/Conductivity
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/64515b3c-5134-448a-9c19-939ce1958424"
},
// ObservationDefinition/Bioburden
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/64515b3c-5134-448a-9c19-949ce1958424"
}
]
}
]
},
// ObservationDefinition/BacterialEndotoxins
{
"title" : "Thawing and Formulation Process Parameter Results",
"code" : // text value="Overall set of actions"/
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStep-local-pq",
"code" : "ThawingandFormulationProcessParameterResultsStep",
"display" : "Thawing and Formulation Process Parameter Resultss"
}
]
},
"action" : [
{
"title" : "???",
"code" : {
"text" : "???"
},
"action" : [
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/74515a3c-5034-448a-9c19-938ce1958424"
},
// ObservationDefinition/ThawingTemp
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/fc27b5d6-9fe2-91c2-2d16-47cb5b295e72"
},
// ObservationDefinition/ThawingTime
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/fc17b5d5-9fe1-91c2-2d06-47cb5b295e72"
},
// ObservationDefinition/formulationVesselMixingSpeed
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/fc27b5d5-9fe1-92c2-2d06-47cb5b295e73"
}
]
}
]
},
// ObservationDefinition/formulationVesselMixingTime
{
"title" : "Thawing and Formulation Performance Indicator Results",
"code" : // text value="Overall set of actions"/
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStep-local-pq",
"code" : "ThawingandFormulationPerformanceIndicatorResultsStep",
"display" : "Thawing and Formulation Performance Indicator Results"
}
]
},
"action" : [
{
"title" : "???",
"code" : {
"text" : "???"
},
"action" : [
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-47cb5b295e72"
},
// ObservationDefinition/ThawingFBPPIpH
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/64515a3c-5034-448a-9c19-938ce1958424"
},
// ObservationDefinition/ThawingOsmolality
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/74515a3c-5134-448a-9c19-939ce1958424"
},
// ObservationDefinition/ThawingConductivity
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/64515b4c-5134-448a-9c19-949ce1958424"
},
// ObservationDefinition/ThawingBacterialEndotoxins
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/64515b3c-5134-448a-9c19-949ce1958434"
}
]
}
]
},
// ObservationDefinition/Polysorbate
{
"title" : "Bioburden Reduction Filtration Process Parameter Results",
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStep-local-pq",
"code" : "BioburdenReductionFiltrationProcessParameterResultsStep",
"display" : "Bioburden Reduction Filtration Process Parameter Results"
}
]
},
"action" : [
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/74515b3c-5134-448a-9c19-949ce1958434"
}
]
},
// ObservationDefinition/FiltrationPressure
{
"title" : "Bioburden Reduction Filtration Performance Indicator Results",
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStep-local-pq",
"code" : "BioburdenReductionFiltrationPerformanceIndicatorResultsStep",
"display" : "Bioburden Reduction Filtration Performance Indicator Results"
}
]
},
"action" : [
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/64515b3c-5134-448a-9c19-939ce1958434"
},
// ObservationDefinition/PreFiltrationBioburden
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/75515b3c-5134-448a-9c19-949ce1958434"
}
]
},
// ObservationDefinition/PostFiltrationFilterIntegrity
{
"title" : "Media Challenge Hold Times",
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStep-local-pq",
"code" : "MediaChallengeHoldTimesStep",
"display" : "Media Challenge Hold Times"
}
]
},
"action" : [
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/75515c3c-5134-448a-9c19-949ce1958434"
}
]
},
// ObservationDefinition/MediaHoldTime
{
"title" : "Media Challenge Results",
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStep-local-pq",
"code" : "MediaChallengeResultsStep",
"display" : "Media Challenge Results"
}
]
},
"action" : [
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/64515b3c-5134-448a-9c19-939ce1958524"
},
// ObservationDefinition/MediaBioburden
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/64515b3c-5134-448a-9d19-939ce1958524"
}
]
},
// ObservationDefinition/GrowthPromotion
{
"title" : "Filtered Formulated Drug Product Performance Indicator Results",
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStep-local-pq",
"code" : "FilteredFormulatedDrugProductPerformanceIndicatorResultsStep",
"display" : "Filtered Formulated Drug Product Performance Indicator Results"
}
]
},
"action" : [
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/64525a3d-5034-448a-9c19-938ce1958424"
},
// ObservationDefinition/SE-UHPLCMainPeak
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/64525a4d-5034-448a-9c19-938ce1958424"
},
// ObservationDefinition/SE-UHPLCMainPeakGraph
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/64525a33-5034-448a-9c19-938ce1958424"
}
]
},
// ObservationDefinition/SE-UHPLCHMW
{
"title" : "Fill Weight Summary",
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStep-local-pq",
"code" : "FillWeightSummaryStep",
"display" : "Fill Weight Summary"
}
]
},
"action" : [
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/64515b3c-5134-448a-9c19-939ce2958524"
}
]
},
// ObservationDefinition/FillWeight
{
"title" : "Filling Homogeneity Quality Attributes",
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStep-local-pq",
"code" : "FillingHomogeneityQualityAttributesStep",
"display" : "Filling Homogeneity Quality Attributes"
}
],
"text" : "Filling Homogeneity Quality Attributes"
},
"action" : [
{
"code" : {
"text" : "Conclusion"
},
"definitionCanonical" : "ObservationDefinition/22525a3c-5035-448a-9c19-938ce1958424"
}
]
},
// ObservationDefinition/conclusionHomogeneity
{
"title" : "Filling Results Summary",
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStep-local-pq",
"code" : "FillingResultsSummaryStep",
"display" : "Filling Results Summary"
}
]
},
"action" : [
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/74515b3c-5134-448a-9c19-939ce1958524"
},
// ObservationDefinition/ProteinConcentration
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/74515b3c-5234-448a-9c19-939ce1958524"
}
]
},
// ObservationDefinition/Polysorbate80Concentration
{
"title" : "Statistical Evaluation of Homogeneity Data",
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStep-local-pq",
"code" : "StatisticalEvaluationOfHomogeneityDataStep",
"display" : "Statistical Evaluation of Homogeneity Data"
}
]
},
"action" : [
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/74515b3c-5134-448a-9c19-939ce1958534"
},
// ObservationDefinition/ProteinConcentrationStats
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/74515b3c-5234-448a-9c19-939ce1958524"
}
]
},
// ObservationDefinition/Polysorbate80Concentration
{
"title" : "Consistency of the Lyophilization Process",
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStep-local-pq",
"code" : "ConsistencyoftheLyophilizationProcessStep",
"display" : "Consistency of the Lyophilization Process"
}
]
},
"action" : [
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/fc27b6d6-9fe2-91c2-2d16-47cb5b295e72"
},
// ObservationDefinition/ResidualMoisture
{
"code" : {
"text" : "Definition"
},
"definitionCanonical" : "ActivityDefinition/b664977d-799d-a1ce-928a-6def2a9955bd"
}
]
},
// ActivityDefinition/LyophilizationAct
{
"title" : "Lyophilization Homogeneity",
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStep-local-pq",
"code" : "LyophilizationHomogeneityStep",
"display" : "Lyophilization Homogeneity Results"
}
]
},
"action" : [
// there are 2 types of obs that correspond to this. Ones per batch, with a %, and ones that are not per batch and have a conclusion (and a number of samples)
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/64525a3d-5134-448a-9c19-938ce1958424"
},
// ObservationDefinition/SE-UHPLCMainPeakLyoph
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/64525a3d-5144-448a-9c19-938ce1958424"
}
]
}
]
}
},
// ObservationDefinition/SE-UHPLCHMWLyoph
// there are 2 types of obs that correspond to this. Ones per batch, with a %, and ones that are not per batch and have a conclusion (and a number of samples)
// no tests just a conclusion
{
"fullUrl" : "urn:uuid:b664977d-799d-a1ce-928a-6def2a9955bd",
"resource" : {
"resourceType" : "ActivityDefinition",
"id" : "b664977d-799d-a1ce-928a-6def2a9955bd",
"text" : // LyophilizationAct
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ActivityDefinition</b><a name=\"b664977d-799d-a1ce-928a-6def2a9955bd\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ActivityDefinition "b664977d-799d-a1ce-928a-6def2a9955bd" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ActivityDefinition/b664977d-799d-a1ce-928a-6def2a9955bd</code></p><p><b>title</b>: Lyophilization</p><p><b>status</b>: active</p></div>"
},
"url" : "http://example-server.com/fhir/ActivityDefinition/b664977d-799d-a1ce-928a-6def2a9955bd",
"title" : "Lyophilization",
"status" : "active"
}
},
// <meta>
<profile value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/ActivityDefinition-test-drug-pq"/>
</meta>
// http://example-server.com/fhir/ActivityDefinition/b664977d-799d-a1ce-928a-6def2a9955bd
{
"fullUrl" : "urn:uuid:378fbe5f-5926-3a5c-4c64-5428df877b08",
"resource" : {
"resourceType" : "Organization",
"id" : "378fbe5f-5926-3a5c-4c64-5428df877b08",
"text" : // 378fbe5f-5926-3a5c-4c64-5428df877b08
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Organization</b><a name=\"378fbe5f-5926-3a5c-4c64-5428df877b08\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Organization "378fbe5f-5926-3a5c-4c64-5428df877b08" </p></div><p><b>name</b>: Testing Lab</p></div>"
},
"name" : "Testing Lab"
}
},
{
"fullUrl" : "urn:uuid:b664977d-799d-a1ce-928a-5def2a9955bd",
"resource" : {
"resourceType" : "DiagnosticReport",
"id" : "processValidationReport",
"text" : // ideally this wants a subject, but it can only be a Medication (batch) and we have multiple.
however the observations themselves do have subjects
{
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: DiagnosticReport</b><a name=\"processValidationReport\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource DiagnosticReport "processValidationReport" </p></div><p><b>Triggered by</b>: <a href=\"Bundle-bundle-drug-substance-characterization-pq-ex1.html#PlanDefinition_2038e4c7-22b8-4c56-2d28-6c077648763f\">PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f</a></p><p><b>status</b>: final</p><p><b>code</b>: Process Validation Report <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-reportType-local-pq.html\">CodeSystem - Report Type</a>#Process Validation Report)</span></p><p><b>effective</b>: 2020-12</p><p><b>result</b>: </p><ul><li><a href=\"#Observation_9c56948a-2a39-6609-1c01-4d197ea57a33\">See above (Observation/9c56948a-2a39-6609-1c01-4d197ea57a33)</a></li><li><a href=\"#Observation_9c56948a-3a39-6609-1c01-4d197ea57a33\">See above (Observation/9c56948a-3a39-6609-1c01-4d197ea57a33)</a></li><li><a href=\"#Observation_9c56948a-4a39-6609-1c01-4d197ea57a33\">See above (Observation/9c56948a-4a39-6609-1c01-4d197ea57a33)</a></li><li><a href=\"#Observation_9c56948a-2a39-6609-2c01-4d197ea57a33\">See above (Observation/9c56948a-2a39-6609-2c01-4d197ea57a33)</a></li><li><a href=\"#Observation_9c56948a-3a39-6609-2c01-4d197ea57a33\">See above (Observation/9c56948a-3a39-6609-2c01-4d197ea57a33)</a></li><li><a href=\"#Observation_9c56948a-4a39-6609-3c01-4d197ea57a33\">See above (Observation/9c56948a-4a39-6609-3c01-4d197ea57a33)</a></li><li><a href=\"#Observation_44aa47fd-8964-4f96-6495-b2bec7f160e7\">See above (Observation/44aa47fd-8964-4f96-6495-b2bec7f160e7)</a></li><li><a href=\"#Observation_54aa47fd-8964-4f96-6495-b2bec7f160e7\">See above (Observation/54aa47fd-8964-4f96-6495-b2bec7f160e7)</a></li><li><a href=\"#Observation_54aa48fd-8964-4f96-6495-b2bec7f160e7\">See above (Observation/54aa48fd-8964-4f96-6495-b2bec7f160e7)</a></li><li><a href=\"#Observation_44aa47fd-8964-4f96-6495-b2bec7f161e7\">See above (Observation/44aa47fd-8964-4f96-6495-b2bec7f161e7)</a></li><li><a href=\"#Observation_54aa47fd-8964-4f96-6495-b2bec7f162e7\">See above (Observation/54aa47fd-8964-4f96-6495-b2bec7f162e7)</a></li><li><a href=\"#Observation_54aa48fd-8964-4f96-6495-b2bec7f163e7\">See above (Observation/54aa48fd-8964-4f96-6495-b2bec7f163e7)</a></li><li><a href=\"#Observation_44aa47fd-8964-5f96-6495-b2bec7f161e7\">See above (Observation/44aa47fd-8964-5f96-6495-b2bec7f161e7)</a></li><li><a href=\"#Observation_44aa47fd-9964-5f96-6495-b2bec7f161e8\">See above (Observation/44aa47fd-9964-5f96-6495-b2bec7f161e8)</a></li><li><a href=\"#Observation_44aa47fd-8964-5f96-6495-b2bec7f161e8\">See above (Observation/44aa47fd-8964-5f96-6495-b2bec7f161e8)</a></li><li><a href=\"#Observation_44aa47fd-8964-5f96-7495-b2bec7f161e8\">See above (Observation/44aa47fd-8964-5f96-7495-b2bec7f161e8)</a></li><li><a href=\"#Observation_44aa47fd-9964-5f97-6495-b2bec7f161e8\">See above (Observation/44aa47fd-9964-5f97-6495-b2bec7f161e8)</a></li><li><a href=\"#Observation_44aa47fd-8964-5f98-6495-b2bec7f161e8\">See above (Observation/44aa47fd-8964-5f98-6495-b2bec7f161e8)</a></li><li><a href=\"#Observation_44aa47fd-8964-5f99-7495-b2bec7f161e8\">See above (Observation/44aa47fd-8964-5f99-7495-b2bec7f161e8)</a></li><li><a href=\"#Observation_54aa47fd-9964-5f97-6495-b2bec7f161e8\">See above (Observation/54aa47fd-9964-5f97-6495-b2bec7f161e8)</a></li><li><a href=\"#Observation_64aa47fd-8964-5f98-6495-b2bec7f161e8\">See above (Observation/64aa47fd-8964-5f98-6495-b2bec7f161e8)</a></li><li><a href=\"#Observation_74aa47fd-8964-5f99-7495-b2bec7f161e8\">See above (Observation/74aa47fd-8964-5f99-7495-b2bec7f161e8)</a></li><li><a href=\"#Observation_44ba47fd-8964-4f96-6495-b2bec7f161e7\">See above (Observation/44ba47fd-8964-4f96-6495-b2bec7f161e7)</a></li><li><a href=\"#Observation_54ca47fd-8964-4f96-6495-b2bec7f162e7\">See above (Observation/54ca47fd-8964-4f96-6495-b2bec7f162e7)</a></li><li><a href=\"#Observation_54da48fd-8964-4f96-6495-b2bec7f163e7\">See above (Observation/54da48fd-8964-4f96-6495-b2bec7f163e7)</a></li><li><a href=\"#Observation_44ba47fd-8964-5f96-6495-b2bec7f161e7\">See above (Observation/44ba47fd-8964-5f96-6495-b2bec7f161e7)</a></li><li><a href=\"#Observation_44ba47fd-8964-4f97-6495-b2bec7f161e7\">See above (Observation/44ba47fd-8964-4f97-6495-b2bec7f161e7)</a></li><li><a href=\"#Observation_54ca47fd-8964-4f98-6495-b2bec7f162e7\">See above (Observation/54ca47fd-8964-4f98-6495-b2bec7f162e7)</a></li><li><a href=\"#Observation_54da48fd-8964-4f99-6495-b2bec7f163e7\">See above (Observation/54da48fd-8964-4f99-6495-b2bec7f163e7)</a></li><li><a href=\"#Observation_55aa47fd-9964-5f97-6495-b2bec7f161e8\">See above (Observation/55aa47fd-9964-5f97-6495-b2bec7f161e8)</a></li><li><a href=\"#Observation_45aa47fd-8964-4f96-6495-b2bec7f160f7\">See above (Observation/45aa47fd-8964-4f96-6495-b2bec7f160f7)</a></li><li><a href=\"#Observation_54aa47fd-9964-5f97-6495-b2bec8f161e8\">See above (Observation/54aa47fd-9964-5f97-6495-b2bec8f161e8)</a></li><li><a href=\"#Observation_54aa47fd-9964-5f97-6495-b2bec8f162e8\">See above (Observation/54aa47fd-9964-5f97-6495-b2bec8f162e8)</a></li><li><a href=\"#Observation_54aa47fd-9965-5f97-6495-b2bec8f161e8\">See above (Observation/54aa47fd-9965-5f97-6495-b2bec8f161e8)</a></li><li><a href=\"#Observation_44ba47fd-8964-4f96-6495-b2bec7f161e8\">See above (Observation/44ba47fd-8964-4f96-6495-b2bec7f161e8)</a></li><li><a href=\"#Observation_44ba47fd-9964-4f96-6495-b2bec7f161e8\">See above (Observation/44ba47fd-9964-4f96-6495-b2bec7f161e8)</a></li><li><a href=\"#Observation_44ba47fd-9964-4f96-6496-b2bec7f161e8\">See above (Observation/44ba47fd-9964-4f96-6496-b2bec7f161e8)</a></li><li><a href=\"#Observation_54ba47fd-8964-4f96-6495-b2bec7f161e7\">See above (Observation/54ba47fd-8964-4f96-6495-b2bec7f161e7)</a></li><li><a href=\"#Observation_54ba47fd-8964-4f96-6495-b2bec7f161e8\">See above (Observation/54ba47fd-8964-4f96-6495-b2bec7f161e8)</a></li><li><a href=\"#Observation_54ba47fd-8964-4f96-6495-b2bec7f161e9\">See above (Observation/54ba47fd-8964-4f96-6495-b2bec7f161e9)</a></li><li><a href=\"#Observation_54ba48fd-8964-4f96-6495-b2bec7f161e7\">See above (Observation/54ba48fd-8964-4f96-6495-b2bec7f161e7)</a></li><li><a href=\"#Observation_54bb47fd-8964-4f96-6495-b2bec7f161e7\">See above (Observation/54bb47fd-8964-4f96-6495-b2bec7f161e7)</a></li><li><a href=\"#Observation_54ba47fd-9964-4f96-6495-b2bec7f161e8\">See above (Observation/54ba47fd-9964-4f96-6495-b2bec7f161e8)</a></li><li><a href=\"#Observation_54ba47fe-8964-4f96-6495-b2bec7f161e9\">See above (Observation/54ba47fe-8964-4f96-6495-b2bec7f161e9)</a></li><li><a href=\"#Observation_64ba48fd-8964-4f96-6495-b2bec7f161e7\">See above (Observation/64ba48fd-8964-4f96-6495-b2bec7f161e7)</a></li></ul><p><b>conclusion</b>: The samples have been assessed and the conclusion is...</p></div>"
},
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/workflow-triggeredBy",
"valueReference" : {
"reference" : "PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f"
}
}
],
"status" : "final",
"code" : // PlanDefinition/plandefinition-drug-pq-ex1-validation-protocol
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-reportType-local-pq",
"code" : "Process Validation Report",
"display" : "Process Validation Report"
}
]
},
"effectiveDateTime" : "2020-12",
"result" : [
{
"reference" : "Observation/9c56948a-2a39-6609-1c01-4d197ea57a33"
},
// Observation/bufferVesselMixingSpeed1
{
"reference" : "Observation/9c56948a-3a39-6609-1c01-4d197ea57a33"
},
// Observation/bufferVesselMixingSpeed2
{
"reference" : "Observation/9c56948a-4a39-6609-1c01-4d197ea57a33"
},
// Observation/bufferVesselMixingSpeed3
{
"reference" : "Observation/9c56948a-2a39-6609-2c01-4d197ea57a33"
},
// Observation/bufferVesselMixingTime1
{
"reference" : "Observation/9c56948a-3a39-6609-2c01-4d197ea57a33"
},
// Observation/bufferVesselMixingTime2
{
"reference" : "Observation/9c56948a-4a39-6609-3c01-4d197ea57a33"
},
// Observation/bufferVesselMixingTime3
{
"reference" : "Observation/44aa47fd-8964-4f96-6495-b2bec7f160e7"
},
// Observation/ph1
{
"reference" : "Observation/54aa47fd-8964-4f96-6495-b2bec7f160e7"
},
// Observation/ph2
{
"reference" : "Observation/54aa48fd-8964-4f96-6495-b2bec7f160e7"
},
// Observation/ph3
{
"reference" : "Observation/44aa47fd-8964-4f96-6495-b2bec7f161e7"
},
// Observation/osmolality1
{
"reference" : "Observation/54aa47fd-8964-4f96-6495-b2bec7f162e7"
},
// Observation/osmolality2
{
"reference" : "Observation/54aa48fd-8964-4f96-6495-b2bec7f163e7"
},
// Observation/osmolality3
{
"reference" : "Observation/44aa47fd-8964-5f96-6495-b2bec7f161e7"
},
// Observation/postFiltrationFilterIntegrity1
{
"reference" : "Observation/44aa47fd-9964-5f96-6495-b2bec7f161e8"
},
// Observation/mediaChallengeHoldTimesStep1
{
"reference" : "Observation/44aa47fd-8964-5f96-6495-b2bec7f161e8"
},
// Observation/mediaChallengeHoldTimesStep2
{
"reference" : "Observation/44aa47fd-8964-5f96-7495-b2bec7f161e8"
},
// Observation/mediaChallengeHoldTimesStep3
{
"reference" : "Observation/44aa47fd-9964-5f97-6495-b2bec7f161e8"
},
// Observation/mediaChallengeBioburden1
{
"reference" : "Observation/44aa47fd-8964-5f98-6495-b2bec7f161e8"
},
// Observation/mediaChallengeBioburden2
{
"reference" : "Observation/44aa47fd-8964-5f99-7495-b2bec7f161e8"
},
// Observation/mediaChallengeBioburden3
{
"reference" : "Observation/54aa47fd-9964-5f97-6495-b2bec7f161e8"
},
// Observation/growthPromotion1
{
"reference" : "Observation/64aa47fd-8964-5f98-6495-b2bec7f161e8"
},
// Observation/growthPromotion2
{
"reference" : "Observation/74aa47fd-8964-5f99-7495-b2bec7f161e8"
},
// Observation/growthPromotion3
{
"reference" : "Observation/44ba47fd-8964-4f96-6495-b2bec7f161e7"
},
// Observation/SE-UHPLCMainPeak1
{
"reference" : "Observation/54ca47fd-8964-4f96-6495-b2bec7f162e7"
},
// Observation/SE-UHPLCMainPeak2
{
"reference" : "Observation/54da48fd-8964-4f96-6495-b2bec7f163e7"
},
// Observation/SE-UHPLCMainPeak3
{
"reference" : "Observation/44ba47fd-8964-5f96-6495-b2bec7f161e7"
},
// Observation/SE-UHPLCMainPeakGraph1
{
"reference" : "Observation/44ba47fd-8964-4f97-6495-b2bec7f161e7"
},
// Observation/SE-UHPLCHMW1
{
"reference" : "Observation/54ca47fd-8964-4f98-6495-b2bec7f162e7"
},
// Observation/SE-UHPLCHMW2
{
"reference" : "Observation/54da48fd-8964-4f99-6495-b2bec7f163e7"
},
// Observation/SE-UHPLCHMW3
{
"reference" : "Observation/55aa47fd-9964-5f97-6495-b2bec7f161e8"
},
// Observation/fillWeight1
{
"reference" : "Observation/45aa47fd-8964-4f96-6495-b2bec7f160f7"
},
// Observation/fillingHomogeneityConclusion-nosubject
{
"reference" : "Observation/54aa47fd-9964-5f97-6495-b2bec8f161e8"
},
// Observation/proteinConcentration1
{
"reference" : "Observation/54aa47fd-9964-5f97-6495-b2bec8f162e8"
},
// Observation/polysorbate2
{
"reference" : "Observation/54aa47fd-9965-5f97-6495-b2bec8f161e8"
},
// Observation/proteinConcentrationStats1
{
"reference" : "Observation/44ba47fd-8964-4f96-6495-b2bec7f161e8"
},
// Observation/residualMoisture1
{
"reference" : "Observation/44ba47fd-9964-4f96-6495-b2bec7f161e8"
},
// Observation/residualMoisture2
{
"reference" : "Observation/44ba47fd-9964-4f96-6496-b2bec7f161e8"
},
// Observation/residualMoisture3
{
"reference" : "Observation/54ba47fd-8964-4f96-6495-b2bec7f161e7"
},
// Observation/SE-UHPLCMainPeakLyoph1
{
"reference" : "Observation/54ba47fd-8964-4f96-6495-b2bec7f161e8"
},
// Observation/SE-UHPLCMainPeakLyoph2
{
"reference" : "Observation/54ba47fd-8964-4f96-6495-b2bec7f161e9"
},
// Observation/SE-UHPLCMainPeakLyoph3
{
"reference" : "Observation/54ba48fd-8964-4f96-6495-b2bec7f161e7"
},
// Observation/SE-UHPLCMainPeakLyophConclusionObs
{
"reference" : "Observation/54bb47fd-8964-4f96-6495-b2bec7f161e7"
},
// Observation/SE-UHPLCHMWLyoph1
{
"reference" : "Observation/54ba47fd-9964-4f96-6495-b2bec7f161e8"
},
// Observation/SE-UHPLCHMWLyoph2
{
"reference" : "Observation/54ba47fe-8964-4f96-6495-b2bec7f161e9"
},
// Observation/SE-UHPLCHMWLyoph3
{
"reference" : "Observation/64ba48fd-8964-4f96-6495-b2bec7f161e7"
}
],
"conclusion" : "The samples have been assessed and the conclusion is..."
}
},
// Observation/SE-UHPLCHMWLyophConclusionObs
{
"fullUrl" : "urn:uuid:fd17b5d6-9fe1-91c2-2d06-47cb5b295e72",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "fd17b5d6-9fe1-91c2-2d06-47cb5b295e72",
"text" : // bufferVesselMixingSpeed
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"fd17b5d6-9fe1-91c2-2d06-47cb5b295e72\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "fd17b5d6-9fe1-91c2-2d06-47cb5b295e72" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72</code></p><p><b>title</b>: Buffer vessel mixing speed (rpm)</p><p><b>status</b>: active</p><p><b>code</b>: Buffer vessel mixing speed (rpm) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Buffer vessel mixing speed (rpm))</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>150-250 rpm</td></tr></table></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72",
"title" : "Buffer vessel mixing speed (rpm)",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Buffer vessel mixing speed (rpm)",
"display" : "Buffer vessel mixing speed (rpm)"
}
],
"text" : "Buffer vessel mixing speed (rpm)"
},
"qualifiedValue" : [
{
"range" : {
"low" : {
"value" : 150,
"unit" : "rpm"
},
"high" : {
"value" : 250,
"unit" : "rpm"
}
}
}
]
}
},
{
"fullUrl" : "urn:uuid:fc17b5d5-9fe1-91c2-2d06-47cb5b295e72",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "fc17b5d5-9fe1-91c2-2d06-47cb5b295e72",
"text" : // formulationVesselMixingSpeed
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"fc17b5d5-9fe1-91c2-2d06-47cb5b295e72\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "fc17b5d5-9fe1-91c2-2d06-47cb5b295e72" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fc17b5d5-9fe1-91c2-2d06-47cb5b295e72</code></p><p><b>title</b>: Formulation vessel mixing speed (rpm)</p><p><b>status</b>: active</p><p><b>code</b>: Formulation vessel mixing speed (rpm) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Formulation vessel mixing speed (rpm))</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>150-250 rpm</td></tr></table></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/fc17b5d5-9fe1-91c2-2d06-47cb5b295e72",
"title" : "Formulation vessel mixing speed (rpm)",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/fc17b5d5-9fe1-91c2-2d06-47cb5b295e72
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Formulation vessel mixing speed (rpm)",
"display" : "Formulation vessel mixing speed (rpm)"
}
],
"text" : "Formulation vessel mixing speed (rpm)"
},
"qualifiedValue" : [
{
"range" : {
"low" : {
"value" : 150,
"unit" : "rpm"
},
"high" : {
"value" : 250,
"unit" : "rpm"
}
}
}
]
}
},
{
"fullUrl" : "urn:uuid:fc17b5d5-9fe1-91c2-2d06-47cb5b295e73",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "fc17b5d5-9fe1-91c2-2d06-47cb5b295e73",
"text" : // bufferVesselMixingTime
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"fc17b5d5-9fe1-91c2-2d06-47cb5b295e73\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "fc17b5d5-9fe1-91c2-2d06-47cb5b295e73" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fc17b5d5-9fe1-91c2-2d06-47cb5b295e73</code></p><p><b>title</b>: Buffer vessel mixing time (min)</p><p><b>status</b>: active</p><p><b>code</b>: Buffer vessel mixing time (min) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Buffer vessel mixing time (min))</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>45-55 mins</td></tr></table></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/fc17b5d5-9fe1-91c2-2d06-47cb5b295e73",
"title" : "Buffer vessel mixing time (min)",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/fc17b5d5-9fe1-91c2-2d06-47cb5b295e73
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Buffer vessel mixing time (min)",
"display" : "Buffer vessel mixing time (min)"
}
],
"text" : "Buffer vessel mixing time (min)"
},
"qualifiedValue" : [
{
"range" : {
"low" : {
"value" : 45,
"unit" : "mins",
"system" : "http://unitsofmeasure.org",
"code" : "min"
},
"high" : {
"value" : 55,
"unit" : "mins",
"system" : "http://unitsofmeasure.org",
"code" : "min"
}
}
}
]
}
},
{
"fullUrl" : "urn:uuid:fc27b5d5-9fe1-92c2-2d06-47cb5b295e73",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "fc27b5d5-9fe1-92c2-2d06-47cb5b295e73",
"text" : // formulationVesselMixingTime
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"fc27b5d5-9fe1-92c2-2d06-47cb5b295e73\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "fc27b5d5-9fe1-92c2-2d06-47cb5b295e73" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fc27b5d5-9fe1-92c2-2d06-47cb5b295e73</code></p><p><b>title</b>: Formulation vessel mixing time (min)</p><p><b>status</b>: active</p><p><b>code</b>: Formulation vessel mixing time (min) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Formulation vessel mixing time (min))</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>45-55 mins</td></tr></table></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/fc27b5d5-9fe1-92c2-2d06-47cb5b295e73",
"title" : "Formulation vessel mixing time (min)",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/fc27b5d5-9fe1-92c2-2d06-47cb5b295e73
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Formulation vessel mixing time (min)",
"display" : "Formulation vessel mixing time (min)"
}
],
"text" : "Formulation vessel mixing time (min)"
},
"qualifiedValue" : [
{
"range" : {
"low" : {
"value" : 45,
"unit" : "mins",
"system" : "http://unitsofmeasure.org",
"code" : "min"
},
"high" : {
"value" : 55,
"unit" : "mins",
"system" : "http://unitsofmeasure.org",
"code" : "min"
}
}
}
]
}
},
{
"fullUrl" : "urn:uuid:fc27b6d6-9fe2-91c2-2d16-47cb5b295e72",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "fc27b6d6-9fe2-91c2-2d16-47cb5b295e72",
"text" : // ResidualMoisture
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"fc27b6d6-9fe2-91c2-2d16-47cb5b295e72\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "fc27b6d6-9fe2-91c2-2d16-47cb5b295e72" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fc27b6d6-9fe2-91c2-2d16-47cb5b295e72</code></p><p><b>title</b>: Residual Moisture (%)</p><p><b>status</b>: active</p><p><b>code</b>: ResidualMoisture <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Residual Moisture "Residual Moisture")</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>?-7.15</td></tr></table><blockquote><p><b>component</b></p><p><b>code</b>: Residual Moisture - Min <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Residual Moisture - Min)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Residual Moisture - Max <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Residual Moisture - Max)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Number of Samples <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SAMP)</span></p></blockquote></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/fc27b6d6-9fe2-91c2-2d16-47cb5b295e72",
"title" : "Residual Moisture (%)",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/fc27b6d6-9fe2-91c2-2d16-47cb5b295e72
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Residual Moisture",
"display" : "Residual Moisture"
}
],
"text" : "ResidualMoisture"
},
"qualifiedValue" : [
{
"range" : {
"high" : {
"value" : 7.15,
"unit" : "%",
"system" : "http://unitsofmeasure.org",
"code" : "%"
}
}
}
],
"component" : [
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Residual Moisture - Min",
"display" : "Residual Moisture - Min"
}
]
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Residual Moisture - Max",
"display" : "Residual Moisture - Max"
}
]
}
},
{
"code" : // are expected to have a component that says number of samples
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SAMP",
"display" : "Number of Samples"
}
]
}
}
]
}
},
{
"fullUrl" : "urn:uuid:fc27b5d6-9fe1-91c2-2d16-47cb5b295e72",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "fc27b5d6-9fe1-91c2-2d16-47cb5b295e72",
"text" : // ThawingFBPPIpH
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"fc27b5d6-9fe1-91c2-2d16-47cb5b295e72\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "fc27b5d6-9fe1-91c2-2d16-47cb5b295e72" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-47cb5b295e72</code></p><p><b>title</b>: pH</p><p><b>status</b>: active</p><p><b>code</b>: pH <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#pH)</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>6.55-7.15 pH</td></tr></table></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-47cb5b295e72",
"title" : "pH",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-47cb5b295e72
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "pH",
"display" : "pH"
}
],
"text" : "pH"
},
"qualifiedValue" : [
{
"range" : {
"low" : {
"value" : 6.55,
"unit" : "pH",
"system" : "http://unitsofmeasure.org",
"code" : "pH"
},
"high" : {
"value" : 7.15,
"unit" : "pH",
"system" : "http://unitsofmeasure.org",
"code" : "pH"
}
}
}
]
}
},
{
"fullUrl" : "urn:uuid:fc27b5d6-9fe2-91c2-2d16-47cb5b295e72",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "fc27b5d6-9fe2-91c2-2d16-47cb5b295e72",
"text" : // ThawingTime
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"fc27b5d6-9fe2-91c2-2d16-47cb5b295e72\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "fc27b5d6-9fe2-91c2-2d16-47cb5b295e72" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe2-91c2-2d16-47cb5b295e72</code></p><p><b>title</b>: Thaw Time</p><p><b>status</b>: active</p><p><b>code</b>: Thaw Time (hr) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Thaw Time "Thaw Time")</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>?-3</td></tr></table></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe2-91c2-2d16-47cb5b295e72",
"title" : "Thaw Time",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe2-91c2-2d16-47cb5b295e72
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Thaw Time",
"display" : "Thaw Time"
}
],
"text" : "Thaw Time (hr)"
},
"qualifiedValue" : [
{
"range" : {
"high" : {
"value" : 3,
"unit" : "hour",
"system" : "http://unitsofmeasure.org",
"code" : "h"
}
}
}
]
}
},
{
"fullUrl" : "urn:uuid:fc17b5d6-9fe1-91c2-2d16-47cb5b295e72",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "fc17b5d6-9fe1-91c2-2d16-47cb5b295e72",
"text" : // FBPPIpH
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"fc17b5d6-9fe1-91c2-2d16-47cb5b295e72\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "fc17b5d6-9fe1-91c2-2d16-47cb5b295e72" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fc17b5d6-9fe1-91c2-2d16-47cb5b295e72</code></p><p><b>title</b>: pH</p><p><b>status</b>: active</p><p><b>code</b>: pH <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#pH)</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>6.95-7.05 pH</td></tr></table></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/fc17b5d6-9fe1-91c2-2d16-47cb5b295e72",
"title" : "pH",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/fc17b5d6-9fe1-91c2-2d16-47cb5b295e72
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "pH",
"display" : "pH"
}
],
"text" : "pH"
},
"qualifiedValue" : [
{
"range" : {
"low" : {
"value" : 6.95,
"unit" : "pH",
"system" : "http://unitsofmeasure.org",
"code" : "pH"
},
"high" : {
"value" : 7.05,
"unit" : "pH",
"system" : "http://unitsofmeasure.org",
"code" : "pH"
}
}
}
]
}
},
{
"fullUrl" : "urn:uuid:64525a3c-5034-448a-9c19-938ce1958424",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "64525a3c-5034-448a-9c19-938ce1958424",
"text" : // Osmolality
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"64525a3c-5034-448a-9c19-938ce1958424\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "64525a3c-5034-448a-9c19-938ce1958424" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/64525a3c-5034-448a-9c19-938ce1958424</code></p><p><b>title</b>: Osmolality</p><p><b>status</b>: active</p><p><b>code</b>: Osmolality (mOsm/kg) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Osmolality "Osmolality")</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>250-300 mOsm/kg</td></tr></table></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/64525a3c-5034-448a-9c19-938ce1958424",
"title" : "Osmolality",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/64525a3c-5034-448a-9c19-938ce1958424
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Osmolality",
"display" : "Osmolality"
}
],
"text" : "Osmolality (mOsm/kg)"
},
"qualifiedValue" : [
{
"range" : {
"low" : // todo UCUM
{
"value" : 250,
"unit" : "mOsm/kg"
},
"high" : // todo UCUM
{
"value" : 300,
"unit" : "mOsm/kg"
}
}
}
]
}
},
{
"fullUrl" : "urn:uuid:64525a3d-5134-448a-9c19-938ce1958424",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "64525a3d-5134-448a-9c19-938ce1958424",
"text" : // SE-UHPLCMainPeakLyoph
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"64525a3d-5134-448a-9c19-938ce1958424\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "64525a3d-5134-448a-9c19-938ce1958424" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/64525a3d-5134-448a-9c19-938ce1958424</code></p><p><b>title</b>: SE-UHPLC Main Peak</p><p><b>status</b>: active</p><p><b>code</b>: SE-UHPLC Main Peak (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCMainPeak "SE-UHPLC Main Peak")</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Extension</b></td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td/><td>85-95 %</td></tr></table><blockquote><p><b>component</b></p><p><b>code</b>: SE-UHPLC Main Peak - Conclusion <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLC Main Peak - Conclusion)</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Extension</b></td></tr><tr><td style=\"display: none\">*</td><td/></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Number of Samples <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#OVERALLSAMP)</span></p></blockquote></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/64525a3d-5134-448a-9c19-938ce1958424",
"title" : "SE-UHPLC Main Peak",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/64525a3d-5134-448a-9c19-938ce1958424
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCMainPeak",
"display" : "SE-UHPLC Main Peak"
}
],
"text" : "SE-UHPLC Main Peak (%)"
},
"qualifiedValue" : [
{
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-display-pq",
"valueString" : "± 5% target"
}
],
"range" : {
"low" : // todo UCUM
{
"value" : 85,
"unit" : "%"
},
"high" : // todo UCUM
{
"value" : 95,
"unit" : "%"
}
}
}
],
"component" : [
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLC Main Peak - Conclusion",
"display" : "SE-UHPLC Main Peak - Conclusion"
}
]
},
"qualifiedValue" : [
{
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-text-pq",
"valueString" : "Pass"
}
]
}
]
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "OVERALLSAMP",
"display" : "Number of Samples"
}
]
}
}
]
}
},
{
"fullUrl" : "urn:uuid:64525a3d-5144-448a-9c19-938ce1958424",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "64525a3d-5144-448a-9c19-938ce1958424",
"text" : // SE-UHPLCHMWLyoph
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"64525a3d-5144-448a-9c19-938ce1958424\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "64525a3d-5144-448a-9c19-938ce1958424" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/64525a3d-5144-448a-9c19-938ce1958424</code></p><p><b>title</b>: SE-UHPLC HMW</p><p><b>status</b>: active</p><p><b>code</b>: SE-UHPLC HMW (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCHMW "SE-UHPLC HMW")</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Extension</b></td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td/><td>88-92 %</td></tr></table><blockquote><p><b>component</b></p><p><b>code</b>: SE-UHPLC HMW - Conclusion <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLC HMW - Conclusion)</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Extension</b></td></tr><tr><td style=\"display: none\">*</td><td/></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Number of Samples <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#OVERALLSAMP)</span></p></blockquote></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/64525a3d-5144-448a-9c19-938ce1958424",
"title" : "SE-UHPLC HMW",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/64525a3d-5144-448a-9c19-938ce1958424
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCHMW",
"display" : "SE-UHPLC HMW"
}
],
"text" : "SE-UHPLC HMW (%)"
},
"qualifiedValue" : [
{
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-display-pq",
"valueString" : "± 2% target"
}
],
"range" : {
"low" : // todo UCUM
{
"value" : 88,
"unit" : "%"
},
"high" : // todo UCUM
{
"value" : 92,
"unit" : "%"
}
}
}
],
"component" : [
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLC HMW - Conclusion",
"display" : "SE-UHPLC HMW - Conclusion"
}
]
},
"qualifiedValue" : [
{
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-text-pq",
"valueString" : "Pass"
}
]
}
]
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "OVERALLSAMP",
"display" : "Number of Samples"
}
]
}
}
]
}
},
{
"fullUrl" : "urn:uuid:64525a3d-5034-448a-9c19-938ce1958424",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "64525a3d-5034-448a-9c19-938ce1958424",
"text" : // SE-UHPLCMainPeak
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"64525a3d-5034-448a-9c19-938ce1958424\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "64525a3d-5034-448a-9c19-938ce1958424" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/64525a3d-5034-448a-9c19-938ce1958424</code></p><p><b>title</b>: SE-UHPLC Main Peak</p><p><b>status</b>: active</p><p><b>code</b>: SE-UHPLC Main Peak (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCMainPeak "SE-UHPLC Main Peak")</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>5-? %</td></tr></table></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/64525a3d-5034-448a-9c19-938ce1958424",
"title" : "SE-UHPLC Main Peak",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/64525a3d-5034-448a-9c19-938ce1958424
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCMainPeak",
"display" : "SE-UHPLC Main Peak"
}
],
"text" : "SE-UHPLC Main Peak (%)"
},
"qualifiedValue" : [
{
"range" : {
"low" : // todo UCUM
{
"value" : 5,
"unit" : "%"
}
}
}
]
}
},
{
"fullUrl" : "urn:uuid:64525a4d-5034-448a-9c19-938ce1958424",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "64525a4d-5034-448a-9c19-938ce1958424",
"text" : // SE-UHPLCMainPeakGraph
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"64525a4d-5034-448a-9c19-938ce1958424\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "64525a4d-5034-448a-9c19-938ce1958424" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/64525a4d-5034-448a-9c19-938ce1958424</code></p><p><b>title</b>: SE-UHPLC Main Peak Graph</p><p><b>status</b>: active</p><p><b>code</b>: SE-UHPLC Main Peak (graph) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCMainPeak "SE-UHPLC Main Peak")</span></p></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/64525a4d-5034-448a-9c19-938ce1958424",
"title" : "SE-UHPLC Main Peak Graph",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/64525a4d-5034-448a-9c19-938ce1958424
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCMainPeak",
"display" : "SE-UHPLC Main Peak"
}
],
"text" : "SE-UHPLC Main Peak (graph)"
}
}
},
{
"fullUrl" : "urn:uuid:64525a33-5034-448a-9c19-938ce1958424",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "64525a33-5034-448a-9c19-938ce1958424",
"text" : // SE-UHPLCHMW
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"64525a33-5034-448a-9c19-938ce1958424\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "64525a33-5034-448a-9c19-938ce1958424" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/64525a33-5034-448a-9c19-938ce1958424</code></p><p><b>title</b>: SE-UHPLC HMW</p><p><b>status</b>: active</p><p><b>code</b>: SE-UHPLC HMW (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCHMW "SE-UHPLC HMW")</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>7-? %</td></tr></table></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/64525a33-5034-448a-9c19-938ce1958424",
"title" : "SE-UHPLC HMW",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/64525a33-5034-448a-9c19-938ce1958424
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCHMW",
"display" : "SE-UHPLC HMW"
}
],
"text" : "SE-UHPLC HMW (%)"
},
"qualifiedValue" : [
{
"range" : {
"low" : // todo UCUM
{
"value" : 7,
"unit" : "%"
}
}
}
]
}
},
{
"fullUrl" : "urn:uuid:22515a3c-5034-448a-9c19-938ce1958424",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "22515a3c-5034-448a-9c19-938ce1958424",
"text" : // conclusion
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"22515a3c-5034-448a-9c19-938ce1958424\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "22515a3c-5034-448a-9c19-938ce1958424" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/22515a3c-5034-448a-9c19-938ce1958424</code></p><p><b>title</b>: Conclusion</p><p><b>status</b>: active</p><p><b>code</b>: Conclusion <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#CONC)</span></p></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/22515a3c-5034-448a-9c19-938ce1958424",
"title" : "Conclusion",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/22515a3c-5034-448a-9c19-938ce1958424
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "CONC",
"display" : "Conclusion"
}
],
"text" : "Conclusion"
}
}
},
{
"fullUrl" : "urn:uuid:22525a3c-5035-448a-9c19-938ce1958424",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "22525a3c-5035-448a-9c19-938ce1958424",
"text" : // conclusionHomogeneity
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"22525a3c-5035-448a-9c19-938ce1958424\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "22525a3c-5035-448a-9c19-938ce1958424" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/22525a3c-5035-448a-9c19-938ce1958424</code></p><p><b>title</b>: Conclusion</p><p><b>status</b>: active</p><p><b>code</b>: Conclusion <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#CONC)</span></p></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/22525a3c-5035-448a-9c19-938ce1958424",
"title" : "Conclusion",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/22525a3c-5035-448a-9c19-938ce1958424
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "CONC",
"display" : "Conclusion"
}
],
"text" : "Conclusion"
}
}
},
{
"fullUrl" : "urn:uuid:64515a3c-5034-448a-9c19-938ce1958424",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "64515a3c-5034-448a-9c19-938ce1958424",
"text" : // ThawingOsmolality
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"64515a3c-5034-448a-9c19-938ce1958424\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "64515a3c-5034-448a-9c19-938ce1958424" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/64515a3c-5034-448a-9c19-938ce1958424</code></p><p><b>title</b>: Osmolality</p><p><b>status</b>: active</p><p><b>code</b>: Osmolality (mOsm/kg) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Osmolality "Osmolality")</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>240-310 mOsm/kg</td></tr></table></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/64515a3c-5034-448a-9c19-938ce1958424",
"title" : "Osmolality",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/64515a3c-5034-448a-9c19-938ce1958424
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Osmolality",
"display" : "Osmolality"
}
],
"text" : "Osmolality (mOsm/kg)"
},
"qualifiedValue" : [
{
"range" : {
"low" : // todo UCUM
{
"value" : 240,
"unit" : "mOsm/kg"
},
"high" : // todo UCUM
{
"value" : 310,
"unit" : "mOsm/kg"
}
}
}
]
}
},
{
"fullUrl" : "urn:uuid:74515a3c-5034-448a-9c19-938ce1958424",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "74515a3c-5034-448a-9c19-938ce1958424",
"text" : // ThawingTemp
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"74515a3c-5034-448a-9c19-938ce1958424\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "74515a3c-5034-448a-9c19-938ce1958424" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/74515a3c-5034-448a-9c19-938ce1958424</code></p><p><b>title</b>: Thawing Temp</p><p><b>status</b>: active</p><p><b>code</b>: Thawing Temp (°C) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Thawing Temp "Thawing Temp")</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>20-24 °C</td></tr></table></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/74515a3c-5034-448a-9c19-938ce1958424",
"title" : "Thawing Temp",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/74515a3c-5034-448a-9c19-938ce1958424
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Thawing Temp",
"display" : "Thawing Temp"
}
],
"text" : "Thawing Temp (°C)"
},
"qualifiedValue" : [
{
"range" : {
"low" : // todo UCUM
{
"value" : 20,
"unit" : "°C"
},
"high" : // todo UCUM
{
"value" : 24,
"unit" : "°C"
}
}
}
]
}
},
{
"fullUrl" : "urn:uuid:64515a3c-5134-448a-9c19-939ce1958424",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "64515a3c-5134-448a-9c19-939ce1958424",
"text" : // Conductivity
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"64515a3c-5134-448a-9c19-939ce1958424\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "64515a3c-5134-448a-9c19-939ce1958424" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/64515a3c-5134-448a-9c19-939ce1958424</code></p><p><b>title</b>: Conductivity</p><p><b>status</b>: active</p><p><b>code</b>: Conductivity (μS/cm) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Conductivity (μS/cm))</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>150-200 μS/cm</td></tr></table></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/64515a3c-5134-448a-9c19-939ce1958424",
"title" : "Conductivity",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/64515a3c-5134-448a-9c19-939ce1958424
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Conductivity (μS/cm)",
"display" : "Conductivity (μS/cm)"
}
]
},
"qualifiedValue" : [
{
"range" : {
"low" : // todo UCUM
{
"value" : 150,
"unit" : "μS/cm"
},
"high" : // todo UCUM
{
"value" : 200,
"unit" : "μS/cm"
}
}
}
]
}
},
{
"fullUrl" : "urn:uuid:74515a3c-5134-448a-9c19-939ce1958424",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "74515a3c-5134-448a-9c19-939ce1958424",
"text" : // ThawingConductivity
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"74515a3c-5134-448a-9c19-939ce1958424\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "74515a3c-5134-448a-9c19-939ce1958424" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/74515a3c-5134-448a-9c19-939ce1958424</code></p><p><b>title</b>: Conductivity</p><p><b>status</b>: active</p><p><b>code</b>: Conductivity (μS/cm) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Conductivity (μS/cm))</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>150-200 μS/cm</td></tr></table></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/74515a3c-5134-448a-9c19-939ce1958424",
"title" : "Conductivity",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/74515a3c-5134-448a-9c19-939ce1958424
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Conductivity (μS/cm)",
"display" : "Conductivity (μS/cm)"
}
]
},
"qualifiedValue" : [
{
"range" : {
"low" : // todo UCUM
{
"value" : 150,
"unit" : "μS/cm"
},
"high" : // todo UCUM
{
"value" : 200,
"unit" : "μS/cm"
}
}
}
]
}
},
{
"fullUrl" : "urn:uuid:64515b3c-5134-448a-9c19-939ce1958424",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "64515b3c-5134-448a-9c19-939ce1958424",
"text" : // Bioburden
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"64515b3c-5134-448a-9c19-939ce1958424\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "64515b3c-5134-448a-9c19-939ce1958424" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/64515b3c-5134-448a-9c19-939ce1958424</code></p><p><b>title</b>: Bioburden</p><p><b>status</b>: active</p><p><b>code</b>: Bioburden (CFU/ 100 mL) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Bioburden (CFU/ 100 mL))</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>50-150 CFU/ 100 mL</td></tr></table></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/64515b3c-5134-448a-9c19-939ce1958424",
"title" : "Bioburden",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/64515b3c-5134-448a-9c19-939ce1958424
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Bioburden (CFU/ 100 mL)",
"display" : "Bioburden (CFU/ 100 mL)"
}
]
},
"qualifiedValue" : [
{
"range" : {
"low" : // todo UCUM
{
"value" : 50,
"unit" : "CFU/ 100 mL"
},
"high" : // todo UCUM
{
"value" : 150,
"unit" : "CFU/ 100 mL"
}
}
}
]
}
},
{
"fullUrl" : "urn:uuid:64515b3c-5134-448a-9c19-939ce1958524",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "64515b3c-5134-448a-9c19-939ce1958524",
"text" : // MediaBioburden
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"64515b3c-5134-448a-9c19-939ce1958524\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "64515b3c-5134-448a-9c19-939ce1958524" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/64515b3c-5134-448a-9c19-939ce1958524</code></p><p><b>title</b>: Bioburden</p><p><b>status</b>: active</p><p><b>code</b>: Bioburden (CFU/ 100 mL) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Bioburden (CFU/ 100 mL))</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>?-10</td></tr></table><blockquote><p><b>component</b></p><p><b>code</b>: Bioburden - Beginning <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Bioburden - Beginning)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Bioburden - End <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Bioburden - End)</span></p></blockquote></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/64515b3c-5134-448a-9c19-939ce1958524",
"title" : "Bioburden",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/64515b3c-5134-448a-9c19-939ce1958524
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Bioburden (CFU/ 100 mL)",
"display" : "Bioburden (CFU/ 100 mL)"
}
]
},
"qualifiedValue" : [
{
"range" : {
"high" : // todo UCUM
{
"value" : 10,
"unit" : "CFU/100 mL"
}
}
}
],
"component" : [
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Bioburden - Beginning",
"display" : "Bioburden - Beginning"
}
]
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Bioburden - End",
"display" : "Bioburden - End"
}
]
}
}
]
}
},
{
"fullUrl" : "urn:uuid:74515b3c-5234-448a-9c19-939ce1958524",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "74515b3c-5234-448a-9c19-939ce1958524",
"text" : // Polysorbate80Concentration
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"74515b3c-5234-448a-9c19-939ce1958524\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "74515b3c-5234-448a-9c19-939ce1958524" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/74515b3c-5234-448a-9c19-939ce1958524</code></p><p><b>title</b>: Polysorbate 80 Concentration</p><p><b>status</b>: active</p><p><b>code</b>: Polysorbate 80 concentration - Middle - Max <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Polysorbate 80 concentration - Middle - Max)</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>0.5-1.5 % w/v</td></tr></table><blockquote><p><b>component</b></p><p><b>code</b>: Polysorbate 80 concentration - Beginning - Min <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Polysorbate 80 concentration - Beginning - Min)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Polysorbate 80 concentration - Beginning - Max <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Polysorbate 80 concentration - Beginning - Max)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Polysorbate 80 concentration - Middle - Min <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Polysorbate 80 concentration - Middle - Min)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Polysorbate 80 concentration - Middle - Max <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Polysorbate 80 concentration - Middle - Max)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Polysorbate 80 concentration - End - Min <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Polysorbate 80 concentration - End - Min)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Polysorbate 80 concentration - End - Max <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Polysorbate 80 concentration - End - Max)</span></p></blockquote></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/74515b3c-5234-448a-9c19-939ce1958524",
"title" : "Polysorbate 80 Concentration",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/74515b3c-5234-448a-9c19-939ce1958524
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Polysorbate 80 concentration - Middle - Max",
"display" : "Polysorbate 80 concentration - Middle - Max"
}
]
},
"qualifiedValue" : [
{
"range" : {
"low" : // todo UCUM
{
"value" : 0.5,
"unit" : "% w/v"
},
"high" : // todo UCUM
{
"value" : 1.5,
"unit" : "% w/v"
}
}
}
],
"component" : [
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Polysorbate 80 concentration - Beginning - Min",
"display" : "Polysorbate 80 concentration - Beginning - Min"
}
]
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Polysorbate 80 concentration - Beginning - Max",
"display" : "Polysorbate 80 concentration - Beginning - Max"
}
]
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Polysorbate 80 concentration - Middle - Min",
"display" : "Polysorbate 80 concentration - Middle - Min"
}
]
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Polysorbate 80 concentration - Middle - Max",
"display" : "Polysorbate 80 concentration - Middle - Max"
}
]
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Polysorbate 80 concentration - End - Min",
"display" : "Polysorbate 80 concentration - End - Min"
}
]
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Polysorbate 80 concentration - End - Max",
"display" : "Polysorbate 80 concentration - End - Max"
}
]
}
}
]
}
},
{
"fullUrl" : "urn:uuid:74515b3c-5134-448a-9c19-939ce1958524",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "74515b3c-5134-448a-9c19-939ce1958524",
"text" : // ProteinConcentration
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"74515b3c-5134-448a-9c19-939ce1958524\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "74515b3c-5134-448a-9c19-939ce1958524" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/74515b3c-5134-448a-9c19-939ce1958524</code></p><p><b>title</b>: Protein Concentration</p><p><b>status</b>: active</p><p><b>code</b>: Protein Concentration (mg/mL) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration (mg/mL))</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>8-10 (mg/mL)</td></tr></table><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Beginning - Min <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Beginning - Min)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Beginning - Max <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Beginning - Max)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Middle - Min <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Middle - Min)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Middle - Max <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Middle - Max)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - End - Min <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - End - Min)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - End - Max <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - End - Max)</span></p></blockquote></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/74515b3c-5134-448a-9c19-939ce1958524",
"title" : "Protein Concentration",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/74515b3c-5134-448a-9c19-939ce1958524
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration (mg/mL)",
"display" : "Protein Concentration (mg/mL)"
}
]
},
"qualifiedValue" : [
{
"range" : {
"low" : // todo UCUM
{
"value" : 8,
"unit" : "(mg/mL)"
},
"high" : // todo UCUM
{
"value" : 10,
"unit" : "(mg/mL)"
}
}
}
],
"component" : [
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Beginning - Min",
"display" : "Protein Concentration - Beginning - Min"
}
]
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Beginning - Max",
"display" : "Protein Concentration - Beginning - Max"
}
]
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Middle - Min",
"display" : "Protein Concentration - Middle - Min"
}
]
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Middle - Max",
"display" : "Protein Concentration - Middle - Max"
}
]
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - End - Min",
"display" : "Protein Concentration - End - Min"
}
]
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - End - Max",
"display" : "Protein Concentration - End - Max"
}
]
}
}
]
}
},
{
"fullUrl" : "urn:uuid:74515b3c-5134-448a-9c19-939ce1958534",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "74515b3c-5134-448a-9c19-939ce1958534",
"text" : // ProteinConcentrationStats
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"74515b3c-5134-448a-9c19-939ce1958534\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "74515b3c-5134-448a-9c19-939ce1958534" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/74515b3c-5134-448a-9c19-939ce1958534</code></p><p><b>title</b>: Protein Concentration Stats</p><p><b>status</b>: active</p><p><b>code</b>: Protein Concentration Statistics <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration Statistics)</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>8-10 (mg/mL)</td></tr></table><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Beginning - Middle - Mean <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Beginning - Middle - Mean)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Beginning - End - Mean <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Beginning - End - Mean)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Middle - End - Mean <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Middle - End - Mean)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Beginning - Middle - Lower <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Beginning - Middle - Lower)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Beginning - End - Lower <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Beginning - End - Lower)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Middle - End - Lower <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Middle - End - Lower)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Beginning - Middle - Higher <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Beginning - Middle - Higher)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Beginning - End - Higher <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Beginning - End - Higher)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Middle - End - Higher <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Middle - End - Higher)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Conclusion <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Conclusion)</span></p></blockquote></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/74515b3c-5134-448a-9c19-939ce1958534",
"title" : "Protein Concentration Stats",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/74515b3c-5134-448a-9c19-939ce1958534
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration Statistics",
"display" : "Protein Concentration Statistics"
}
]
},
"qualifiedValue" : [
{
"range" : {
"low" : // todo UCUM
{
"value" : 8,
"unit" : "(mg/mL)"
},
"high" : // todo UCUM
{
"value" : 10,
"unit" : "(mg/mL)"
}
}
}
],
"component" : [
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Beginning - Middle - Mean",
"display" : "Protein Concentration - Beginning - Middle - Mean"
}
]
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Beginning - End - Mean",
"display" : "Protein Concentration - Beginning - End - Mean"
}
]
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Middle - End - Mean",
"display" : "Protein Concentration - Middle - End - Mean"
}
]
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Beginning - Middle - Lower",
"display" : "Protein Concentration - Beginning - Middle - Lower"
}
]
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Beginning - End - Lower",
"display" : "Protein Concentration - Beginning - End - Lower"
}
]
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Middle - End - Lower",
"display" : "Protein Concentration - Middle - End - Lower"
}
]
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Beginning - Middle - Higher",
"display" : "Protein Concentration - Beginning - Middle - Higher"
}
]
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Beginning - End - Higher",
"display" : "Protein Concentration - Beginning - End - Higher"
}
]
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Middle - End - Higher",
"display" : "Protein Concentration - Middle - End - Higher"
}
]
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Conclusion",
"display" : "Protein Concentration - Conclusion"
}
]
}
}
]
}
},
{
"fullUrl" : "urn:uuid:64515b3c-5134-448a-9c19-939ce2958524",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "64515b3c-5134-448a-9c19-939ce2958524",
"text" : // FillWeight
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"64515b3c-5134-448a-9c19-939ce2958524\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "64515b3c-5134-448a-9c19-939ce2958524" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/64515b3c-5134-448a-9c19-939ce2958524</code></p><p><b>title</b>: Fill Weight</p><p><b>status</b>: active</p><p><b>code</b>: Fill Weight <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Fill Weight)</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Extension</b></td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td/><td>95-105 g</td></tr></table><blockquote><p><b>component</b></p><p><b>code</b>: Bioburden - Beginning <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Bioburden - Beginning)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Bioburden - End <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Bioburden - End)</span></p></blockquote></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/64515b3c-5134-448a-9c19-939ce2958524",
"title" : "Fill Weight",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/64515b3c-5134-448a-9c19-939ce2958524
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Fill Weight",
"display" : "Fill Weight"
}
]
},
"qualifiedValue" : [
{
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-target-pq",
"valueQuantity" : // todo UCUM
{
"value" : 100,
"unit" : "g"
}
}
],
"range" : {
"low" : // todo UCUM
{
"value" : 95,
"unit" : "g"
},
"high" : // todo UCUM
{
"value" : 105,
"unit" : "g"
}
}
}
],
"component" : [
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Bioburden - Beginning",
"display" : "Bioburden - Beginning"
}
]
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Bioburden - End",
"display" : "Bioburden - End"
}
]
}
}
]
}
},
{
"fullUrl" : "urn:uuid:64515b3c-5134-448a-9d19-939ce1958524",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "64515b3c-5134-448a-9d19-939ce1958524",
"text" : // GrowthPromotion
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"64515b3c-5134-448a-9d19-939ce1958524\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "64515b3c-5134-448a-9d19-939ce1958524" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/64515b3c-5134-448a-9d19-939ce1958524</code></p><p><b>title</b>: Growth Promotion</p><p><b>status</b>: active</p><p><b>code</b>: Growth Promotion <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#GrowthPromotion)</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Extension</b></td></tr><tr><td style=\"display: none\">*</td><td/></tr></table><blockquote><p><b>component</b></p><p><b>code</b>: Growth Promotion - Beginning <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Growth Promotion - Beginning)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Growth Promotion - End <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Growth Promotion - End)</span></p></blockquote></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/64515b3c-5134-448a-9d19-939ce1958524",
"title" : "Growth Promotion",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/64515b3c-5134-448a-9d19-939ce1958524
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "GrowthPromotion",
"display" : "Growth Promotion"
}
]
},
"qualifiedValue" : [
{
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-text-pq",
"valueString" : "Pass"
}
]
}
],
"component" : [
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Growth Promotion - Beginning",
"display" : "Growth Promotion - Beginning"
}
]
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Growth Promotion - End",
"display" : "Growth Promotion - End"
}
]
}
}
]
}
},
{
"fullUrl" : "urn:uuid:64515b3c-5134-448a-9c19-939ce1958434",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "64515b3c-5134-448a-9c19-939ce1958434",
"text" : // PreFiltrationBioburden
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"64515b3c-5134-448a-9c19-939ce1958434\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "64515b3c-5134-448a-9c19-939ce1958434" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/64515b3c-5134-448a-9c19-939ce1958434</code></p><p><b>title</b>: Pre-filtration Bioburden</p><p><b>status</b>: active</p><p><b>code</b>: Pre-filtration Bioburden (CFU/ 100 mL) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Pre-filtration Bioburden (CFU/ 100 mL))</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>?-150</td></tr></table></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/64515b3c-5134-448a-9c19-939ce1958434",
"title" : "Pre-filtration Bioburden",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/64515b3c-5134-448a-9c19-939ce1958434
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Pre-filtration Bioburden (CFU/ 100 mL)",
"display" : "Pre-filtration Bioburden (CFU/ 100 mL)"
}
]
},
"qualifiedValue" : [
{
"range" : {
"high" : // todo UCUM
{
"value" : 150,
"unit" : "CFU/ 100 mL"
}
}
}
]
}
},
{
"fullUrl" : "urn:uuid:64515b3c-5134-448a-9c19-949ce1958424",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "64515b3c-5134-448a-9c19-949ce1958424",
"text" : // BacterialEndotoxins
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"64515b3c-5134-448a-9c19-949ce1958424\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "64515b3c-5134-448a-9c19-949ce1958424" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/64515b3c-5134-448a-9c19-949ce1958424</code></p><p><b>title</b>: Bacterial Endotoxins</p><p><b>status</b>: active</p><p><b>code</b>: Bacterial Endotoxins (EU/mL) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Bacterial Endotoxins (EU/mL))</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>40-120 EU/mL</td></tr></table></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/64515b3c-5134-448a-9c19-949ce1958424",
"title" : "Bacterial Endotoxins",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/64515b3c-5134-448a-9c19-949ce1958424
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Bacterial Endotoxins (EU/mL)",
"display" : "Bacterial Endotoxins (EU/mL)"
}
]
},
"qualifiedValue" : [
{
"range" : {
"low" : // todo UCUM
{
"value" : 40,
"unit" : "EU/mL"
},
"high" : // todo UCUM
{
"value" : 120,
"unit" : "EU/mL"
}
}
}
]
}
},
{
"fullUrl" : "urn:uuid:64515b4c-5134-448a-9c19-949ce1958424",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "64515b4c-5134-448a-9c19-949ce1958424",
"text" : // ThawingBacterialEndotoxins
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"64515b4c-5134-448a-9c19-949ce1958424\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "64515b4c-5134-448a-9c19-949ce1958424" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/64515b4c-5134-448a-9c19-949ce1958424</code></p><p><b>title</b>: Bacterial Endotoxins</p><p><b>status</b>: active</p><p><b>code</b>: Bacterial Endotoxins (EU/mL) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Bacterial Endotoxins (EU/mL))</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>50-110 EU/mL</td></tr></table></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/64515b4c-5134-448a-9c19-949ce1958424",
"title" : "Bacterial Endotoxins",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/64515b4c-5134-448a-9c19-949ce1958424
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Bacterial Endotoxins (EU/mL)",
"display" : "Bacterial Endotoxins (EU/mL)"
}
]
},
"qualifiedValue" : [
{
"range" : {
"low" : // todo UCUM
{
"value" : 50,
"unit" : "EU/mL"
},
"high" : // todo UCUM
{
"value" : 110,
"unit" : "EU/mL"
}
}
}
]
}
},
{
"fullUrl" : "urn:uuid:74515b3c-5134-448a-9c19-949ce1958434",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "74515b3c-5134-448a-9c19-949ce1958434",
"text" : // FiltrationPressure
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"74515b3c-5134-448a-9c19-949ce1958434\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "74515b3c-5134-448a-9c19-949ce1958434" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/74515b3c-5134-448a-9c19-949ce1958434</code></p><p><b>title</b>: Filtration Pressure</p><p><b>status</b>: active</p><p><b>code</b>: FiltrationPressure (psig) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#FiltrationPressure (psig))</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>100-150 psig</td></tr></table></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/74515b3c-5134-448a-9c19-949ce1958434",
"title" : "Filtration Pressure",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/74515b3c-5134-448a-9c19-949ce1958434
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "FiltrationPressure (psig)",
"display" : "FiltrationPressure (psig)"
}
]
},
"qualifiedValue" : [
{
"range" : {
"low" : // todo UCUM
{
"value" : 100,
"unit" : "psig"
},
"high" : // todo UCUM
{
"value" : 150,
"unit" : "psig"
}
}
}
]
}
},
{
"fullUrl" : "urn:uuid:75515b3c-5134-448a-9c19-949ce1958434",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "75515b3c-5134-448a-9c19-949ce1958434",
"text" : // PostFiltrationFilterIntegrity
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"75515b3c-5134-448a-9c19-949ce1958434\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "75515b3c-5134-448a-9c19-949ce1958434" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/75515b3c-5134-448a-9c19-949ce1958434</code></p><p><b>title</b>: Post-filtration Filter Integrity (psig)</p><p><b>status</b>: active</p><p><b>code</b>: Post-filtration Filter Integrity (psig) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Post-filtration Filter Integrity (psig))</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>100-? psig</td></tr></table><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td></tr><tr><td style=\"display: none\">*</td><td>Test Success <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#test-success)</span></td></tr></table></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/75515b3c-5134-448a-9c19-949ce1958434",
"title" : "Post-filtration Filter Integrity (psig)",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/75515b3c-5134-448a-9c19-949ce1958434
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Post-filtration Filter Integrity (psig)",
"display" : "Post-filtration Filter Integrity (psig)"
}
]
},
"qualifiedValue" : [
{
"range" : {
"low" : // todo UCUM
{
"value" : 100,
"unit" : "psig"
}
}
}
],
"component" : [
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "test-success",
"display" : "Test Success"
}
]
}
}
]
}
},
{
"fullUrl" : "urn:uuid:75515c3c-5134-448a-9c19-949ce1958434",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "75515c3c-5134-448a-9c19-949ce1958434",
"text" : // MediaHoldTime
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"75515c3c-5134-448a-9c19-949ce1958434\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "75515c3c-5134-448a-9c19-949ce1958434" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/75515c3c-5134-448a-9c19-949ce1958434</code></p><p><b>title</b>: Media Challenge Hold Times (hours)</p><p><b>status</b>: active</p><p><b>code</b>: Media Challenge Hold Times <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Media Challenge Hold Times)</span></p></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/75515c3c-5134-448a-9c19-949ce1958434",
"title" : "Media Challenge Hold Times (hours)",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/75515c3c-5134-448a-9c19-949ce1958434
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Media Challenge Hold Times",
"display" : "Media Challenge Hold Times"
}
]
}
}
},
{
"fullUrl" : "urn:uuid:64515b3c-5134-448a-9c19-949ce1958434",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "64515b3c-5134-448a-9c19-949ce1958434",
"text" : // Polysorbate
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"64515b3c-5134-448a-9c19-949ce1958434\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "64515b3c-5134-448a-9c19-949ce1958434" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/64515b3c-5134-448a-9c19-949ce1958434</code></p><p><b>title</b>: Polysorbate 80</p><p><b>status</b>: active</p><p><b>code</b>: Polysorbate 80 (% w/v) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Polysorbate 80 (% w/v))</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>25-55 % w/v</td></tr></table></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/64515b3c-5134-448a-9c19-949ce1958434",
"title" : "Polysorbate 80",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/64515b3c-5134-448a-9c19-949ce1958434
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Polysorbate 80 (% w/v)",
"display" : "Polysorbate 80 (% w/v)"
}
]
},
"qualifiedValue" : [
{
"range" : {
"low" : // todo UCUM
{
"value" : 25,
"unit" : "% w/v"
},
"high" : // todo UCUM
{
"value" : 55,
"unit" : "% w/v"
}
}
}
]
}
},
{
"fullUrl" : "urn:uuid:339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51",
"resource" : {
"resourceType" : "Medication",
"id" : "339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51",
"text" : // medication-batch-information-drug-pq-ex1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Medication</b><a name=\"339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Medication "339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51" </p></div><p><b>code</b>: <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><h3>Batches</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Extension</b></td><td><b>LotNumber</b></td></tr><tr><td style=\"display: none\">*</td><td>, , , , , , , , , , , , </td><td>999909</td></tr></table><hr/><blockquote><p><b>Generated Narrative: PackagedProductDefinition #ppd1-nosubject</b><a name=\"ppd1-nosubject\"> </a></p><p><b>containedItemQuantity</b>: 20 ml</p></blockquote></div>"
},
"contained" : [
{
"resourceType" : "PackagedProductDefinition",
"id" : "ppd1-nosubject",
"containedItemQuantity" : [
{
"value" : 20,
"unit" : "ml"
}
]
}
],
"code" : {
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-medication-definition-pq",
"valueReference" : {
"reference" : "MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5"
}
},
// todo consider change this be the MID?
// MedicinalProductDefinition/medicinalproductdefinition-drug-product-pq-ex1
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-package-definition-pq",
"valueReference" : {
"reference" : "#ppd1-nosubject"
}
}
]
},
"batch" : // totalVolume
// considered this as presentation (package size). Unclear how to use it, esp. for non-liquids
{
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
"extension" : [
{
"url" : "manufacturingDate",
"valueDateTime" : "2020-06-01"
},
{
"url" : "batchQuantity",
"valueQuantity" : {
"value" : 100100,
"unit" : "tablets"
}
},
{
"url" : "batchUtilization",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
"code" : "C185328",
"display" : "Stability Study"
}
],
"text" : "PPQ / Stability"
}
},
{
"url" : "assignedManufacturer",
"valueReference" : {
"reference" : "Organization/0102bca4-46c1-a6bf-1025-cd403fee710a"
}
},
// Organization/manufacturer
{
"url" : "container",
"extension" : [
{
"url" : "closureSystemDescription",
"valueString" : "100 cc HDPE Bottle 2 g desiccant"
}
]
}
]
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq",
"valueDateTime" : "2019-09-08"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-formulation-number-pq",
"valueString" : "1333224444"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-designation-pq",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-batch-designation-local-pq",
"code" : "minimum",
"display" : "Minimum"
}
],
"text" : "Minimum"
}
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-number-of-vials-pq",
"valuePositiveInt" : 3
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-number-of-full-shelves-pq",
"valuePositiveInt" : 4
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-number-of-partial-shelves-pq",
"valuePositiveInt" : 5
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-substance-batch-pq",
"valueReference" : {
"reference" : "Substance/fc078762-81c5-5656-9744-13c7ad1e595b"
}
},
// Substance/substance-dxpq-ex1
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-packaging-date-pq",
"valueDateTime" : "2020-08"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-packaging-site-pq",
"valueReference" : {
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b07"
}
},
// Organization/packaging
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq",
"valueQuantity" : {
"value" : 4.81,
"unit" : "kg"
}
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-unfiltered-pq",
"valueQuantity" : {
"value" : 4.91,
"unit" : "kg"
}
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-target-fill-weight-pq",
"valueQuantity" : {
"value" : 30,
"unit" : "g"
}
}
],
"lotNumber" : "999909"
}
}
},
// local extensions
{
"fullUrl" : "urn:uuid:339b69fd-4ab1-a1e9-9ea5-1973ba2f6b51",
"resource" : {
"resourceType" : "Medication",
"id" : "339b69fd-4ab1-a1e9-9ea5-1973ba2f6b51",
"text" : // medication-batch-information-drug-pq-ex1b-unlinked
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Medication</b><a name=\"339b69fd-4ab1-a1e9-9ea5-1973ba2f6b51\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Medication "339b69fd-4ab1-a1e9-9ea5-1973ba2f6b51" </p></div><p><b>code</b>: <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><h3>Batches</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Extension</b></td><td><b>LotNumber</b></td></tr><tr><td style=\"display: none\">*</td><td>, , , , , , , , , , </td><td>999910</td></tr></table><hr/><blockquote><p><b>Generated Narrative: PackagedProductDefinition #ppd1-nosubject</b><a name=\"ppd1-nosubject\"> </a></p><p><b>containedItemQuantity</b>: 50 ml</p></blockquote></div>"
},
"contained" : [
{
"resourceType" : "PackagedProductDefinition",
"id" : "ppd1-nosubject",
"containedItemQuantity" : [
{
"value" : 50,
"unit" : "ml"
}
]
}
],
"code" : {
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-medication-definition-pq",
"valueReference" : {
"reference" : "MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5"
}
},
// todo consider change this be the MID?
// MedicinalProductDefinition/medicinalproductdefinition-drug-product-pq-ex1
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-package-definition-pq",
"valueReference" : {
"reference" : "#ppd1-nosubject"
}
}
]
},
"batch" : {
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
"extension" : [
{
"url" : "manufacturingDate",
"valueDateTime" : "2020-06-02"
},
{
"url" : "batchQuantity",
"valueQuantity" : {
"value" : 100100,
"unit" : "tablets"
}
},
{
"url" : "batchUtilization",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
"code" : "C185328",
"display" : "Stability Study"
}
],
"text" : "PPQ / Stability"
}
},
{
"url" : "assignedManufacturer",
"valueReference" : {
"reference" : "Organization/0102bca4-46c1-a6bf-1025-cd403fee710a"
}
},
// Organization/manufacturer
{
"url" : "container",
"extension" : [
{
"url" : "closureSystemDescription",
"valueString" : "100 cc HDPE Bottle 2 g desiccant"
}
]
}
]
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq",
"valueDateTime" : "2019-09-08"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-formulation-number-pq",
"valueString" : "1333224444"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-designation-pq",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-batch-designation-local-pq",
"code" : "maximum",
"display" : "Maximum"
}
],
"text" : "Maximum"
}
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-number-of-vials-pq",
"valuePositiveInt" : 3
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-substance-batch-pq",
"valueReference" : {
"reference" : "Substance/fc078762-81c5-5656-9744-13c7ad1e595b"
}
},
// Substance/substance-dxpq-ex1
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-packaging-date-pq",
"valueDateTime" : "2020-08"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-packaging-site-pq",
"valueReference" : {
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b07"
}
},
// Organization/packaging
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq",
"valueQuantity" : {
"value" : 4.81,
"unit" : "kg"
}
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-unfiltered-pq",
"valueQuantity" : {
"value" : 4.91,
"unit" : "kg"
}
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-target-fill-weight-pq",
"valueQuantity" : {
"value" : 30,
"unit" : "g"
}
}
],
"lotNumber" : "999910"
}
}
},
// local extensions
{
"fullUrl" : "urn:uuid:a9dfda53-734b-045f-7ae4-94a6281d53bc",
"resource" : {
"resourceType" : "Medication",
"id" : "a9dfda53-734b-045f-7ae4-94a6281d53bc",
"text" : // medication-actual-batch-2
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Medication</b><a name=\"a9dfda53-734b-045f-7ae4-94a6281d53bc\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Medication "a9dfda53-734b-045f-7ae4-94a6281d53bc" </p></div><p><b>code</b>: <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><h3>Batches</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Extension</b></td><td><b>LotNumber</b></td></tr><tr><td style=\"display: none\">*</td><td>, , , , , , , , , , </td><td>999911</td></tr></table><hr/><blockquote><p><b>Generated Narrative: PackagedProductDefinition #ppd1-nosubject</b><a name=\"ppd1-nosubject\"> </a></p><p><b>containedItemQuantity</b>: 20 ml</p></blockquote></div>"
},
"contained" : [
{
"resourceType" : "PackagedProductDefinition",
"id" : "ppd1-nosubject",
"containedItemQuantity" : [
{
"value" : 20,
"unit" : "ml"
}
]
}
],
"code" : {
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-medication-definition-pq",
"valueReference" : {
"reference" : "MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5"
}
},
// MedicinalProductDefinition/medicinalproductdefinition-drug-product-pq-ex1
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-package-definition-pq",
"valueReference" : {
"reference" : "#ppd1-nosubject"
}
}
]
},
"batch" : {
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
"extension" : [
{
"url" : "manufacturingDate",
"valueDateTime" : "2020-06-01"
},
{
"url" : "batchQuantity",
"valueQuantity" : {
"value" : 100050,
"unit" : "tablets"
}
},
{
"url" : "batchUtilization",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
"code" : "C185328",
"display" : "Stability Study"
}
],
"text" : "PPQ / Stability"
}
},
{
"url" : "assignedManufacturer",
"valueReference" : {
"reference" : "Organization/0102bca4-46c1-a6bf-1025-cd403fee710a"
}
},
// Organization/manufacturer
{
"url" : "container",
"extension" : [
{
"url" : "closureSystemDescription",
"valueString" : "100 cc HDPE Bottle 2 g desiccant"
}
]
}
]
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq",
"valueDateTime" : "2019-09-08"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-formulation-number-pq",
"valueString" : "1333225555"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-designation-pq",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-batch-designation-local-pq",
"code" : "maximum",
"display" : "Maximum"
}
],
"text" : "Maximum"
}
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-number-of-vials-pq",
"valuePositiveInt" : 4
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-substance-batch-pq",
"valueReference" : {
"reference" : "Substance/cb31d747-2338-88d5-342c-8e9c097e4dad"
}
},
// Substance/actual-batch-substance-2
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-packaging-date-pq",
"valueDateTime" : "2020-08"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-packaging-site-pq",
"valueReference" : {
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b07"
}
},
// Organization/packaging
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq",
"valueQuantity" : {
"value" : 4.82,
"unit" : "kg"
}
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-unfiltered-pq",
"valueQuantity" : {
"value" : 4.92,
"unit" : "kg"
}
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-target-fill-weight-pq",
"valueQuantity" : {
"value" : 30,
"unit" : "g"
}
}
],
"lotNumber" : "999911"
}
}
},
// local extensions
{
"fullUrl" : "urn:uuid:a9dfda53-734b-045f-7ae5-94a6281d53bc",
"resource" : {
"resourceType" : "Medication",
"id" : "a9dfda53-734b-045f-7ae5-94a6281d53bc",
"text" : // medication-actual-batch-2b-unlinked
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Medication</b><a name=\"a9dfda53-734b-045f-7ae5-94a6281d53bc\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Medication "a9dfda53-734b-045f-7ae5-94a6281d53bc" </p></div><p><b>code</b>: <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><h3>Batches</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Extension</b></td><td><b>LotNumber</b></td></tr><tr><td style=\"display: none\">*</td><td>, , , , , , , , , , </td><td>999912</td></tr></table><hr/><blockquote><p><b>Generated Narrative: PackagedProductDefinition #ppd1-nosubject</b><a name=\"ppd1-nosubject\"> </a></p><p><b>containedItemQuantity</b>: 50 ml</p></blockquote></div>"
},
"contained" : [
{
"resourceType" : "PackagedProductDefinition",
"id" : "ppd1-nosubject",
"containedItemQuantity" : [
{
"value" : 50,
"unit" : "ml"
}
]
}
],
"code" : {
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-medication-definition-pq",
"valueReference" : {
"reference" : "MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5"
}
},
// MedicinalProductDefinition/medicinalproductdefinition-drug-product-pq-ex1
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-package-definition-pq",
"valueReference" : {
"reference" : "#ppd1-nosubject"
}
}
]
},
"batch" : {
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
"extension" : [
{
"url" : "manufacturingDate",
"valueDateTime" : "2020-06-02"
},
{
"url" : "batchQuantity",
"valueQuantity" : {
"value" : 100050,
"unit" : "tablets"
}
},
{
"url" : "batchUtilization",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
"code" : "C185328",
"display" : "Stability Study"
}
],
"text" : "PPQ / Stability"
}
},
{
"url" : "assignedManufacturer",
"valueReference" : {
"reference" : "Organization/0102bca4-46c1-a6bf-1025-cd403fee710a"
}
},
// Organization/manufacturer
{
"url" : "container",
"extension" : [
{
"url" : "closureSystemDescription",
"valueString" : "100 cc HDPE Bottle 2 g desiccant"
}
]
}
]
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq",
"valueDateTime" : "2019-09-08"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-formulation-number-pq",
"valueString" : "1333225555"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-designation-pq",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-batch-designation-local-pq",
"code" : "maximum",
"display" : "Maximum"
}
],
"text" : "Maximum"
}
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-number-of-vials-pq",
"valuePositiveInt" : 4
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-substance-batch-pq",
"valueReference" : {
"reference" : "Substance/cb31d747-2338-88d5-342c-8e9c097e4dad"
}
},
// Substance/actual-batch-substance-2
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-packaging-date-pq",
"valueDateTime" : "2020-08"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-packaging-site-pq",
"valueReference" : {
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b07"
}
},
// Organization/packaging
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq",
"valueQuantity" : {
"value" : 4.82,
"unit" : "kg"
}
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-unfiltered-pq",
"valueQuantity" : {
"value" : 4.92,
"unit" : "kg"
}
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-target-fill-weight-pq",
"valueQuantity" : {
"value" : 30,
"unit" : "g"
}
}
],
"lotNumber" : "999912"
}
}
},
// local extensions
{
"fullUrl" : "urn:uuid:c6f5fadd-62e6-3a01-93d9-b3b182f67d06",
"resource" : {
"resourceType" : "Medication",
"id" : "c6f5fadd-62e6-3a01-93d9-b3b182f67d06",
"text" : // medication-actual-batch-3
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Medication</b><a name=\"c6f5fadd-62e6-3a01-93d9-b3b182f67d06\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Medication "c6f5fadd-62e6-3a01-93d9-b3b182f67d06" </p></div><p><b>code</b>: <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><h3>Batches</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Extension</b></td><td><b>LotNumber</b></td></tr><tr><td style=\"display: none\">*</td><td>, , , , , , , , , , </td><td>999913</td></tr></table><hr/><blockquote><p><b>Generated Narrative: PackagedProductDefinition #ppd1-nosubject</b><a name=\"ppd1-nosubject\"> </a></p><p><b>containedItemQuantity</b>: 20 ml</p></blockquote></div>"
},
"contained" : [
{
"resourceType" : "PackagedProductDefinition",
"id" : "ppd1-nosubject",
"containedItemQuantity" : [
{
"value" : 20,
"unit" : "ml"
}
]
}
],
"code" : {
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-medication-definition-pq",
"valueReference" : {
"reference" : "MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5"
}
},
// MedicinalProductDefinition/medicinalproductdefinition-drug-product-pq-ex1
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-package-definition-pq",
"valueReference" : {
"reference" : "#ppd1-nosubject"
}
}
]
},
"batch" : {
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
"extension" : [
{
"url" : "manufacturingDate",
"valueDateTime" : "2020-06-01"
},
{
"url" : "batchQuantity",
"valueQuantity" : {
"value" : 100125,
"unit" : "tablets"
}
},
{
"url" : "batchUtilization",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
"code" : "C185328",
"display" : "Stability Study"
}
],
"text" : "PPQ / Stability"
}
},
{
"url" : "assignedManufacturer",
"valueReference" : {
"reference" : "Organization/0102bca4-46c1-a6bf-1025-cd403fee710a"
}
},
// Organization/manufacturer
{
"url" : "container",
"extension" : [
{
"url" : "closureSystemDescription",
"valueString" : "100 cc HDPE Bottle 2 g desiccant"
}
]
}
]
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq",
"valueDateTime" : "2019-09-08"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-formulation-number-pq",
"valueString" : "1333226666"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-designation-pq",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-batch-designation-local-pq",
"code" : "maximum",
"display" : "Maximum"
}
],
"text" : "Maximum"
}
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-number-of-vials-pq",
"valuePositiveInt" : 3
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-substance-batch-pq",
"valueReference" : {
"reference" : "Substance/1551f97b-6f6d-825e-1fb3-44b0b090808c"
}
},
// Substance/actual-batch-substance-3
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-packaging-date-pq",
"valueDateTime" : "2020-08"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-packaging-site-pq",
"valueReference" : {
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b07"
}
},
// Organization/packaging
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq",
"valueQuantity" : {
"value" : 4.83,
"unit" : "kg"
}
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-unfiltered-pq",
"valueQuantity" : {
"value" : 4.93,
"unit" : "kg"
}
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-target-fill-weight-pq",
"valueQuantity" : {
"value" : 30,
"unit" : "g"
}
}
],
"lotNumber" : "999913"
}
}
},
// local extension
{
"fullUrl" : "urn:uuid:c6f5fadd-62e6-3a11-93d9-b3b182f67d06",
"resource" : {
"resourceType" : "Medication",
"id" : "c6f5fadd-62e6-3a11-93d9-b3b182f67d06",
"text" : // medication-actual-batch-3b-unlinked
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Medication</b><a name=\"c6f5fadd-62e6-3a11-93d9-b3b182f67d06\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Medication "c6f5fadd-62e6-3a11-93d9-b3b182f67d06" </p></div><p><b>code</b>: <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><h3>Batches</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Extension</b></td><td><b>LotNumber</b></td></tr><tr><td style=\"display: none\">*</td><td>, , , , , , , , , , </td><td>999914</td></tr></table><hr/><blockquote><p><b>Generated Narrative: PackagedProductDefinition #ppd1-nosubject</b><a name=\"ppd1-nosubject\"> </a></p><p><b>containedItemQuantity</b>: 50 ml</p></blockquote></div>"
},
"contained" : [
{
"resourceType" : "PackagedProductDefinition",
"id" : "ppd1-nosubject",
"containedItemQuantity" : [
{
"value" : 50,
"unit" : "ml"
}
]
}
],
"code" : {
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-medication-definition-pq",
"valueReference" : {
"reference" : "MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5"
}
},
// MedicinalProductDefinition/medicinalproductdefinition-drug-product-pq-ex1
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-package-definition-pq",
"valueReference" : {
"reference" : "#ppd1-nosubject"
}
}
]
},
"batch" : {
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
"extension" : [
{
"url" : "manufacturingDate",
"valueDateTime" : "2020-06-02"
},
{
"url" : "batchQuantity",
"valueQuantity" : {
"value" : 100125,
"unit" : "tablets"
}
},
{
"url" : "batchUtilization",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
"code" : "C185328",
"display" : "Stability Study"
}
],
"text" : "PPQ / Stability"
}
},
{
"url" : "assignedManufacturer",
"valueReference" : {
"reference" : "Organization/0102bca4-46c1-a6bf-1025-cd403fee710a"
}
},
// Organization/manufacturer
{
"url" : "container",
"extension" : [
{
"url" : "closureSystemDescription",
"valueString" : "100 cc HDPE Bottle 2 g desiccant"
}
]
}
]
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq",
"valueDateTime" : "2019-09-08"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-formulation-number-pq",
"valueString" : "1333226666"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-designation-pq",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-batch-designation-local-pq",
"code" : "intermediate",
"display" : "Intermediate"
}
],
"text" : "Intermediate"
}
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-number-of-vials-pq",
"valuePositiveInt" : 3
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-substance-batch-pq",
"valueReference" : {
"reference" : "Substance/1551f97b-6f6d-825e-1fb3-44b0b090808c"
}
},
// Substance/actual-batch-substance-3
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-packaging-date-pq",
"valueDateTime" : "2020-08"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-packaging-site-pq",
"valueReference" : {
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b07"
}
},
// Organization/packaging
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq",
"valueQuantity" : {
"value" : 4.83,
"unit" : "kg"
}
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-unfiltered-pq",
"valueQuantity" : {
"value" : 4.93,
"unit" : "kg"
}
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-target-fill-weight-pq",
"valueQuantity" : {
"value" : 30,
"unit" : "g"
}
}
],
"lotNumber" : "999914"
}
}
},
// local extension
{
"fullUrl" : "urn:uuid:0102bca4-46c1-a6bf-1025-cd403fee710a",
"resource" : {
"resourceType" : "Organization",
"id" : "0102bca4-46c1-a6bf-1025-cd403fee710a",
"text" : // manufacturer
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Organization</b><a name=\"0102bca4-46c1-a6bf-1025-cd403fee710a\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Organization "0102bca4-46c1-a6bf-1025-cd403fee710a" </p></div><p><b>identifier</b>: id:\u00a03010027650</p><p><b>name</b>: AAA Pharmaceutical, Inc.</p><h3>Contacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Address</b></td></tr><tr><td style=\"display: none\">*</td><td>681 Main Street Lumberton New Jersey 08048 USA </td></tr></table></div>"
},
"identifier" : [
{
"system" : "urn:oid:2.16.840.1.113883.4.82",
"value" : "3010027650"
}
],
"name" : "AAA Pharmaceutical, Inc.",
"contact" : [
// FDA establishment identifier
{
"address" : {
"line" : [
"681 Main Street"
],
"city" : "Lumberton",
"state" : "New Jersey",
"postalCode" : "08048",
"country" : "USA"
}
}
]
}
},
{
"fullUrl" : "urn:uuid:378fbe5f-5926-3a5c-4c64-5428df877b07",
"resource" : {
"resourceType" : "Organization",
"id" : "378fbe5f-5926-3a5c-4c64-5428df877b07",
"text" : // packaging
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Organization</b><a name=\"378fbe5f-5926-3a5c-4c64-5428df877b07\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Organization "378fbe5f-5926-3a5c-4c64-5428df877b07" </p></div><p><b>name</b>: MySite</p></div>"
},
"name" : "MySite"
}
},
{
"fullUrl" : "urn:uuid:9c56948a-2a39-6609-1c01-4d197ea57a33",
"resource" : {
"resourceType" : "Observation",
"id" : "9c56948a-2a39-6609-1c01-4d197ea57a33",
"text" : // bufferVesselMixingSpeed1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"9c56948a-2a39-6609-1c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "9c56948a-2a39-6609-1c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_fd17b5d6-9fe1-91c2-2d06-47cb5b295e72\">See above (ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: Buffer vessel mixing speed (rpm) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Buffer vessel mixing speed (rpm))</span></p><p><b>subject</b>: <a href=\"#Medication_339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51\">See above (Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 205 rpm</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"
},
"status" : "final",
"code" : // ObservationDefinition/bufferVesselMixingSpeed
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Buffer vessel mixing speed (rpm)",
"display" : "Buffer vessel mixing speed (rpm)"
}
],
"text" : "Buffer vessel mixing speed (rpm)"
},
"subject" : {
"reference" : "Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-batch-information-drug-pq-ex1
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 205,
"unit" : "rpm"
}
}
},
{
"fullUrl" : "urn:uuid:9c56948a-3a39-6609-1c01-4d197ea57a33",
"resource" : {
"resourceType" : "Observation",
"id" : "9c56948a-3a39-6609-1c01-4d197ea57a33",
"text" : // bufferVesselMixingSpeed2
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"9c56948a-3a39-6609-1c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "9c56948a-3a39-6609-1c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_fd17b5d6-9fe1-91c2-2d06-47cb5b295e72\">See above (ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: Buffer vessel mixing speed (rpm) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Buffer vessel mixing speed (rpm))</span></p><p><b>subject</b>: <a href=\"#Medication_a9dfda53-734b-045f-7ae4-94a6281d53bc\">See above (Medication/a9dfda53-734b-045f-7ae4-94a6281d53bc)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 210 rpm</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"
},
"status" : "final",
"code" : // ObservationDefinition/bufferVesselMixingSpeed
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Buffer vessel mixing speed (rpm)",
"display" : "Buffer vessel mixing speed (rpm)"
}
],
"text" : "Buffer vessel mixing speed (rpm)"
},
"subject" : {
"reference" : "Medication/a9dfda53-734b-045f-7ae4-94a6281d53bc"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-actual-batch-2
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 210,
"unit" : "rpm"
}
}
},
{
"fullUrl" : "urn:uuid:9c56948a-4a39-6609-1c01-4d197ea57a33",
"resource" : {
"resourceType" : "Observation",
"id" : "9c56948a-4a39-6609-1c01-4d197ea57a33",
"text" : // bufferVesselMixingSpeed3
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"9c56948a-4a39-6609-1c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "9c56948a-4a39-6609-1c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_fd17b5d6-9fe1-91c2-2d06-47cb5b295e72\">See above (ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: Buffer vessel mixing speed (rpm) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Buffer vessel mixing speed (rpm))</span></p><p><b>subject</b>: <a href=\"#Medication_c6f5fadd-62e6-3a01-93d9-b3b182f67d06\">See above (Medication/c6f5fadd-62e6-3a01-93d9-b3b182f67d06)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 198 rpm</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"
},
"status" : "final",
"code" : // ObservationDefinition/bufferVesselMixingSpeed
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Buffer vessel mixing speed (rpm)",
"display" : "Buffer vessel mixing speed (rpm)"
}
],
"text" : "Buffer vessel mixing speed (rpm)"
},
"subject" : {
"reference" : "Medication/c6f5fadd-62e6-3a01-93d9-b3b182f67d06"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-actual-batch-3
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 198,
"unit" : "rpm"
}
}
},
{
"fullUrl" : "urn:uuid:9c56948a-2a39-6609-2c01-4d197ea57a33",
"resource" : {
"resourceType" : "Observation",
"id" : "9c56948a-2a39-6609-2c01-4d197ea57a33",
"text" : // bufferVesselMixingTime1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"9c56948a-2a39-6609-2c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "9c56948a-2a39-6609-2c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_fc17b5d5-9fe1-91c2-2d06-47cb5b295e73\">See above (ObservationDefinition/fc17b5d5-9fe1-91c2-2d06-47cb5b295e73)</a></p><p><b>status</b>: final</p><p><b>code</b>: Buffer vessel mixing time (min) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Buffer vessel mixing time (min))</span></p><p><b>subject</b>: <a href=\"#Medication_339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51\">See above (Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 51 mins</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/fc17b5d5-9fe1-91c2-2d06-47cb5b295e73"
},
"status" : "final",
"code" : // ObservationDefinition/bufferVesselMixingTime
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Buffer vessel mixing time (min)",
"display" : "Buffer vessel mixing time (min)"
}
],
"text" : "Buffer vessel mixing time (min)"
},
"subject" : {
"reference" : "Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-batch-information-drug-pq-ex1
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 51,
"unit" : "mins"
}
}
},
{
"fullUrl" : "urn:uuid:9c56948a-3a39-6609-2c01-4d197ea57a33",
"resource" : {
"resourceType" : "Observation",
"id" : "9c56948a-3a39-6609-2c01-4d197ea57a33",
"text" : // bufferVesselMixingTime2
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"9c56948a-3a39-6609-2c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "9c56948a-3a39-6609-2c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_fc17b5d5-9fe1-91c2-2d06-47cb5b295e73\">See above (ObservationDefinition/fc17b5d5-9fe1-91c2-2d06-47cb5b295e73)</a></p><p><b>status</b>: final</p><p><b>code</b>: Buffer vessel mixing time (min) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Buffer vessel mixing time (min))</span></p><p><b>subject</b>: <a href=\"#Medication_a9dfda53-734b-045f-7ae4-94a6281d53bc\">See above (Medication/a9dfda53-734b-045f-7ae4-94a6281d53bc)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 49 mins</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/fc17b5d5-9fe1-91c2-2d06-47cb5b295e73"
},
"status" : "final",
"code" : // ObservationDefinition/bufferVesselMixingTime
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Buffer vessel mixing time (min)",
"display" : "Buffer vessel mixing time (min)"
}
],
"text" : "Buffer vessel mixing time (min)"
},
"subject" : {
"reference" : "Medication/a9dfda53-734b-045f-7ae4-94a6281d53bc"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-actual-batch-2
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 49,
"unit" : "mins"
}
}
},
{
"fullUrl" : "urn:uuid:9c56948a-4a39-6609-3c01-4d197ea57a33",
"resource" : {
"resourceType" : "Observation",
"id" : "9c56948a-4a39-6609-3c01-4d197ea57a33",
"text" : // bufferVesselMixingTime3
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"9c56948a-4a39-6609-3c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "9c56948a-4a39-6609-3c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_fc17b5d5-9fe1-91c2-2d06-47cb5b295e73\">See above (ObservationDefinition/fc17b5d5-9fe1-91c2-2d06-47cb5b295e73)</a></p><p><b>status</b>: final</p><p><b>code</b>: Buffer vessel mixing time (min) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Buffer vessel mixing time (min))</span></p><p><b>subject</b>: <a href=\"#Medication_c6f5fadd-62e6-3a01-93d9-b3b182f67d06\">See above (Medication/c6f5fadd-62e6-3a01-93d9-b3b182f67d06)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 52 mins</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/fc17b5d5-9fe1-91c2-2d06-47cb5b295e73"
},
"status" : "final",
"code" : // ObservationDefinition/bufferVesselMixingTime
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Buffer vessel mixing time (min)",
"display" : "Buffer vessel mixing time (min)"
}
],
"text" : "Buffer vessel mixing time (min)"
},
"subject" : {
"reference" : "Medication/c6f5fadd-62e6-3a01-93d9-b3b182f67d06"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-actual-batch-3
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 52,
"unit" : "mins"
}
}
},
{
"fullUrl" : "urn:uuid:44aa47fd-8964-4f96-6495-b2bec7f160e7",
"resource" : {
"resourceType" : "Observation",
"id" : "44aa47fd-8964-4f96-6495-b2bec7f160e7",
"text" : // ph1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"44aa47fd-8964-4f96-6495-b2bec7f160e7\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "44aa47fd-8964-4f96-6495-b2bec7f160e7" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_fc17b5d6-9fe1-91c2-2d16-47cb5b295e72\">See above (ObservationDefinition/fc17b5d6-9fe1-91c2-2d16-47cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: pH <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#pH)</span></p><p><b>subject</b>: <a href=\"#Medication_339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51\">See above (Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 6.9 pH</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/fc17b5d6-9fe1-91c2-2d16-47cb5b295e72"
},
"status" : "final",
"code" : // ObservationDefinition/FBPPIpH
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "pH",
"display" : "pH"
}
],
"text" : "pH"
},
"subject" : {
"reference" : "Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-batch-information-drug-pq-ex1
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 6.9,
"unit" : "pH"
}
}
},
{
"fullUrl" : "urn:uuid:54aa47fd-8964-4f96-6495-b2bec7f160e7",
"resource" : {
"resourceType" : "Observation",
"id" : "54aa47fd-8964-4f96-6495-b2bec7f160e7",
"text" : // ph2
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"54aa47fd-8964-4f96-6495-b2bec7f160e7\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "54aa47fd-8964-4f96-6495-b2bec7f160e7" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_fc17b5d6-9fe1-91c2-2d16-47cb5b295e72\">See above (ObservationDefinition/fc17b5d6-9fe1-91c2-2d16-47cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: pH <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#pH)</span></p><p><b>subject</b>: <a href=\"#Medication_a9dfda53-734b-045f-7ae4-94a6281d53bc\">See above (Medication/a9dfda53-734b-045f-7ae4-94a6281d53bc)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 7.1 pH</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/fc17b5d6-9fe1-91c2-2d16-47cb5b295e72"
},
"status" : "final",
"code" : // ObservationDefinition/FBPPIpH
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "pH",
"display" : "pH"
}
],
"text" : "pH"
},
"subject" : {
"reference" : "Medication/a9dfda53-734b-045f-7ae4-94a6281d53bc"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-actual-batch-2
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 7.1,
"unit" : "pH"
}
}
},
{
"fullUrl" : "urn:uuid:54aa48fd-8964-4f96-6495-b2bec7f160e7",
"resource" : {
"resourceType" : "Observation",
"id" : "54aa48fd-8964-4f96-6495-b2bec7f160e7",
"text" : // ph3
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"54aa48fd-8964-4f96-6495-b2bec7f160e7\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "54aa48fd-8964-4f96-6495-b2bec7f160e7" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_fc17b5d6-9fe1-91c2-2d16-47cb5b295e72\">See above (ObservationDefinition/fc17b5d6-9fe1-91c2-2d16-47cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: pH <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#pH)</span></p><p><b>subject</b>: <a href=\"#Medication_c6f5fadd-62e6-3a01-93d9-b3b182f67d06\">See above (Medication/c6f5fadd-62e6-3a01-93d9-b3b182f67d06)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 7.2 pH</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/fc17b5d6-9fe1-91c2-2d16-47cb5b295e72"
},
"status" : "final",
"code" : // ObservationDefinition/FBPPIpH
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "pH",
"display" : "pH"
}
],
"text" : "pH"
},
"subject" : {
"reference" : "Medication/c6f5fadd-62e6-3a01-93d9-b3b182f67d06"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-actual-batch-3
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 7.2,
"unit" : "pH"
}
}
},
{
"fullUrl" : "urn:uuid:44aa47fd-9964-5f96-6495-b2bec7f161e8",
"resource" : {
"resourceType" : "Observation",
"id" : "44aa47fd-9964-5f96-6495-b2bec7f161e8",
"text" : // mediaChallengeHoldTimesStep1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"44aa47fd-9964-5f96-6495-b2bec7f161e8\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "44aa47fd-9964-5f96-6495-b2bec7f161e8" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_75515c3c-5134-448a-9c19-949ce1958434\">See above (ObservationDefinition/75515c3c-5134-448a-9c19-949ce1958434)</a></p><p><b>status</b>: final</p><p><b>code</b>: Hold Time (hr) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Hold Time "Hold Time")</span></p><p><b>subject</b>: <a href=\"#Procedure_44aa47fd-8964-5f96-8495-b2bec7f161a8\">See above (Procedure/44aa47fd-8964-5f96-8495-b2bec7f161a8)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 1.25 hours</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/75515c3c-5134-448a-9c19-949ce1958434"
},
"status" : "final",
"code" : // ObservationDefinition/MediaHoldTime
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Hold Time",
"display" : "Hold Time"
}
],
"text" : "Hold Time (hr)"
},
"subject" : {
"reference" : "Procedure/44aa47fd-8964-5f96-8495-b2bec7f161a8"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Procedure/procedure-drug-pq-ex1
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 1.25,
"unit" : "hours"
}
}
},
{
"fullUrl" : "urn:uuid:44aa47fd-8964-5f96-6495-b2bec7f161e8",
"resource" : {
"resourceType" : "Observation",
"id" : "44aa47fd-8964-5f96-6495-b2bec7f161e8",
"text" : // mediaChallengeHoldTimesStep2
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"44aa47fd-8964-5f96-6495-b2bec7f161e8\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "44aa47fd-8964-5f96-6495-b2bec7f161e8" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_75515c3c-5134-448a-9c19-949ce1958434\">See above (ObservationDefinition/75515c3c-5134-448a-9c19-949ce1958434)</a></p><p><b>status</b>: final</p><p><b>code</b>: Hold Time (hr) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Hold Time "Hold Time")</span></p><p><b>subject</b>: <a href=\"#Procedure_44aa47fd-8964-5f96-6495-b2bec7f162a8\">See above (Procedure/44aa47fd-8964-5f96-6495-b2bec7f162a8)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 1.5 hours</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/75515c3c-5134-448a-9c19-949ce1958434"
},
"status" : "final",
"code" : // ObservationDefinition/MediaHoldTime
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Hold Time",
"display" : "Hold Time"
}
],
"text" : "Hold Time (hr)"
},
"subject" : {
"reference" : "Procedure/44aa47fd-8964-5f96-6495-b2bec7f162a8"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Procedure/procedure-run-2
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 1.5,
"unit" : "hours"
}
}
},
{
"fullUrl" : "urn:uuid:44aa47fd-8964-5f96-7495-b2bec7f161e8",
"resource" : {
"resourceType" : "Observation",
"id" : "44aa47fd-8964-5f96-7495-b2bec7f161e8",
"text" : // mediaChallengeHoldTimesStep3
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"44aa47fd-8964-5f96-7495-b2bec7f161e8\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "44aa47fd-8964-5f96-7495-b2bec7f161e8" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_75515c3c-5134-448a-9c19-949ce1958434\">See above (ObservationDefinition/75515c3c-5134-448a-9c19-949ce1958434)</a></p><p><b>status</b>: final</p><p><b>code</b>: Hold Time (hr) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Hold Time "Hold Time")</span></p><p><b>subject</b>: <a href=\"#Procedure_44aa47fd-8964-5f96-6495-b2bec7f163a8\">See above (Procedure/44aa47fd-8964-5f96-6495-b2bec7f163a8)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 1.75 hours</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/75515c3c-5134-448a-9c19-949ce1958434"
},
"status" : "final",
"code" : // ObservationDefinition/MediaHoldTime
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Hold Time",
"display" : "Hold Time"
}
],
"text" : "Hold Time (hr)"
},
"subject" : {
"reference" : "Procedure/44aa47fd-8964-5f96-6495-b2bec7f163a8"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Procedure/procedure-run-3
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 1.75,
"unit" : "hours"
}
}
},
{
"fullUrl" : "urn:uuid:44aa47fd-9964-5f97-6495-b2bec7f161e8",
"resource" : {
"resourceType" : "Observation",
"id" : "44aa47fd-9964-5f97-6495-b2bec7f161e8",
"text" : // mediaChallengeBioburden1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"44aa47fd-9964-5f97-6495-b2bec7f161e8\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "44aa47fd-9964-5f97-6495-b2bec7f161e8" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_64515b3c-5134-448a-9c19-939ce1958524\">See above (ObservationDefinition/64515b3c-5134-448a-9c19-939ce1958524)</a></p><p><b>status</b>: final</p><p><b>code</b>: Bioburden (CFU/ 100 mL) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Bioburden (CFU/ 100 mL))</span></p><p><b>subject</b>: <a href=\"#Procedure_44aa47fd-8964-5f96-8495-b2bec7f161a8\">See above (Procedure/44aa47fd-8964-5f96-8495-b2bec7f161a8)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: Bioburden - Beginning <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Bioburden - Beginning)</span></p><p><b>value</b>: 8.0 CFU/100 mL</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Bioburden - End <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Bioburden - End)</span></p><p><b>value</b>: 9.0 CFU/100 mL</p></blockquote></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/64515b3c-5134-448a-9c19-939ce1958524"
},
"status" : "final",
"code" : // ObservationDefinition/MediaBioburden
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Bioburden (CFU/ 100 mL)",
"display" : "Bioburden (CFU/ 100 mL)"
}
]
},
"subject" : {
"reference" : "Procedure/44aa47fd-8964-5f96-8495-b2bec7f161a8"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Procedure/procedure-drug-pq-ex1
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"component" : [
// Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Bioburden - Beginning",
"display" : "Bioburden - Beginning"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 8.0,
"unit" : "CFU/100 mL"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Bioburden - End",
"display" : "Bioburden - End"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 9.0,
"unit" : "CFU/100 mL"
}
}
]
}
},
{
"fullUrl" : "urn:uuid:44aa47fd-8964-5f98-6495-b2bec7f161e8",
"resource" : {
"resourceType" : "Observation",
"id" : "44aa47fd-8964-5f98-6495-b2bec7f161e8",
"text" : // mediaChallengeBioburden2
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"44aa47fd-8964-5f98-6495-b2bec7f161e8\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "44aa47fd-8964-5f98-6495-b2bec7f161e8" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_64515b3c-5134-448a-9c19-939ce1958524\">See above (ObservationDefinition/64515b3c-5134-448a-9c19-939ce1958524)</a></p><p><b>status</b>: final</p><p><b>code</b>: Bioburden (CFU/ 100 mL) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Bioburden (CFU/ 100 mL))</span></p><p><b>subject</b>: <a href=\"#Procedure_44aa47fd-8964-5f96-6495-b2bec7f162a8\">See above (Procedure/44aa47fd-8964-5f96-6495-b2bec7f162a8)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: Bioburden - Beginning <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Bioburden - Beginning)</span></p><p><b>value</b>: 8.5 CFU/100 mL</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Bioburden - End <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Bioburden - End)</span></p><p><b>value</b>: 8.6 CFU/100 mL</p></blockquote></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/64515b3c-5134-448a-9c19-939ce1958524"
},
"status" : "final",
"code" : // ObservationDefinition/MediaBioburden
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Bioburden (CFU/ 100 mL)",
"display" : "Bioburden (CFU/ 100 mL)"
}
]
},
"subject" : {
"reference" : "Procedure/44aa47fd-8964-5f96-6495-b2bec7f162a8"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Procedure/procedure-run-2
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"component" : [
// Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Bioburden - Beginning",
"display" : "Bioburden - Beginning"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 8.5,
"unit" : "CFU/100 mL"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Bioburden - End",
"display" : "Bioburden - End"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 8.6,
"unit" : "CFU/100 mL"
}
}
]
}
},
{
"fullUrl" : "urn:uuid:44aa47fd-8964-5f99-7495-b2bec7f161e8",
"resource" : {
"resourceType" : "Observation",
"id" : "44aa47fd-8964-5f99-7495-b2bec7f161e8",
"text" : // mediaChallengeBioburden3
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"44aa47fd-8964-5f99-7495-b2bec7f161e8\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "44aa47fd-8964-5f99-7495-b2bec7f161e8" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_64515b3c-5134-448a-9c19-939ce1958524\">See above (ObservationDefinition/64515b3c-5134-448a-9c19-939ce1958524)</a></p><p><b>status</b>: final</p><p><b>code</b>: Bioburden (CFU/ 100 mL) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Bioburden (CFU/ 100 mL))</span></p><p><b>subject</b>: <a href=\"#Procedure_44aa47fd-8964-5f96-6495-b2bec7f163a8\">See above (Procedure/44aa47fd-8964-5f96-6495-b2bec7f163a8)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: Bioburden - Beginning <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Bioburden - Beginning)</span></p><p><b>value</b>: 9.5 CFU/100 mL</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Bioburden - End <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Bioburden - End)</span></p><p><b>value</b>: 10.1 CFU/100 mL</p></blockquote></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/64515b3c-5134-448a-9c19-939ce1958524"
},
"status" : "final",
"code" : // ObservationDefinition/MediaBioburden
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Bioburden (CFU/ 100 mL)",
"display" : "Bioburden (CFU/ 100 mL)"
}
]
},
"subject" : {
"reference" : "Procedure/44aa47fd-8964-5f96-6495-b2bec7f163a8"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Procedure/procedure-run-3
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"component" : [
// Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Bioburden - Beginning",
"display" : "Bioburden - Beginning"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 9.5,
"unit" : "CFU/100 mL"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Bioburden - End",
"display" : "Bioburden - End"
}
]
},
"valueQuantity" : // todproteinConcentration1o UCUM
{
"value" : 10.1,
"unit" : "CFU/100 mL"
}
}
]
}
},
{
"fullUrl" : "urn:uuid:54aa47fd-9965-5f97-6495-b2bec8f161e8",
"resource" : {
"resourceType" : "Observation",
"id" : "54aa47fd-9965-5f97-6495-b2bec8f161e8",
"text" : // proteinConcentrationStats1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"54aa47fd-9965-5f97-6495-b2bec8f161e8\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "54aa47fd-9965-5f97-6495-b2bec8f161e8" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_74515b3c-5134-448a-9c19-939ce1958534\">See above (ObservationDefinition/74515b3c-5134-448a-9c19-939ce1958534)</a></p><p><b>status</b>: final</p><p><b>code</b>: Protein Concentration (mg/mL) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration (mg/mL))</span></p><p><b>subject</b>: <a href=\"#Medication_339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51\">See above (Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Beginning - Middle - Mean <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Beginning - Middle - Mean)</span></p><p><b>value</b>: 8.0 mg/mL</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Beginning - End - Mean <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Beginning - End - Mean)</span></p><p><b>value</b>: 8.05 mg/mL</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Middle - End - Mean <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Middle - End - Mean)</span></p><p><b>value</b>: 8.10 mg/mL</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Beginning - Middle - Lower <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Beginning - Middle - Lower)</span></p><p><b>value</b>: 8.15 mg/mL</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Beginning - End - Lower <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Beginning - End - Lower)</span></p><p><b>value</b>: 8.2 mg/mL</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Middle - End - Lower <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Middle - End - Lower)</span></p><p><b>value</b>: 8.25 mg/mL</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Beginning - Middle - Higher <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Beginning - Middle - Higher)</span></p><p><b>value</b>: 8.45 mg/mL</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Beginning - End - Higher <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Beginning - End - Higher)</span></p><p><b>value</b>: 8.3 mg/mL</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Middle - End - Higher <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Middle - End - Higher)</span></p><p><b>value</b>: 8.35 mg/mL</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Conclusion <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Conclusion)</span></p><p><b>value</b>: Pass</p></blockquote></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/74515b3c-5134-448a-9c19-939ce1958534"
},
"status" : "final",
"code" : // ObservationDefinition/ProteinConcentrationStats
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration (mg/mL)",
"display" : "Protein Concentration (mg/mL)"
}
]
},
"subject" : {
"reference" : "Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-batch-information-drug-pq-ex1
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"component" : [
// Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Beginning - Middle - Mean",
"display" : "Protein Concentration - Beginning - Middle - Mean"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 8.0,
"unit" : "mg/mL"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Beginning - End - Mean",
"display" : "Protein Concentration - Beginning - End - Mean"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 8.05,
"unit" : "mg/mL"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Middle - End - Mean",
"display" : "Protein Concentration - Middle - End - Mean"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 8.10,
"unit" : "mg/mL"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Beginning - Middle - Lower",
"display" : "Protein Concentration - Beginning - Middle - Lower"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 8.15,
"unit" : "mg/mL"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Beginning - End - Lower",
"display" : "Protein Concentration - Beginning - End - Lower"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 8.2,
"unit" : "mg/mL"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Middle - End - Lower",
"display" : "Protein Concentration - Middle - End - Lower"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 8.25,
"unit" : "mg/mL"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Beginning - Middle - Higher",
"display" : "Protein Concentration - Beginning - Middle - Higher"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 8.45,
"unit" : "mg/mL"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Beginning - End - Higher",
"display" : "Protein Concentration - Beginning - End - Higher"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 8.3,
"unit" : "mg/mL"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Middle - End - Higher",
"display" : "Protein Concentration - Middle - End - Higher"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 8.35,
"unit" : "mg/mL"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Conclusion",
"display" : "Protein Concentration - Conclusion"
}
]
},
"valueString" : "Pass"
}
]
}
},
{
"fullUrl" : "urn:uuid:54aa47fd-9964-5f97-6495-b2bec8f161e8",
"resource" : {
"resourceType" : "Observation",
"id" : "54aa47fd-9964-5f97-6495-b2bec8f161e8",
"text" : // proteinConcentration1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"54aa47fd-9964-5f97-6495-b2bec8f161e8\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "54aa47fd-9964-5f97-6495-b2bec8f161e8" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_74515b3c-5134-448a-9c19-939ce1958524\">See above (ObservationDefinition/74515b3c-5134-448a-9c19-939ce1958524)</a></p><p><b>status</b>: final</p><p><b>code</b>: Protein Concentration (mg/mL) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration (mg/mL))</span></p><p><b>subject</b>: <a href=\"#Medication_339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51\">See above (Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Beginning - Min <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Beginning - Min)</span></p><p><b>value</b>: 8.00 mg/mL</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Beginning - Max <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Beginning - Max)</span></p><p><b>value</b>: 8.05 mg/mL</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Middle - Min <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Middle - Min)</span></p><p><b>value</b>: 8.10 mg/mL</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - Middle - Max <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - Middle - Max)</span></p><p><b>value</b>: 8.15 mg/mL</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - End - Min <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - End - Min)</span></p><p><b>value</b>: 8.2 mg/mL</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Protein Concentration - End - Max <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Protein Concentration - End - Max)</span></p><p><b>value</b>: 8.25 mg/mL</p></blockquote></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/74515b3c-5134-448a-9c19-939ce1958524"
},
"status" : "final",
"code" : // ObservationDefinition/ProteinConcentration
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration (mg/mL)",
"display" : "Protein Concentration (mg/mL)"
}
]
},
"subject" : {
"reference" : "Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-batch-information-drug-pq-ex1
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"component" : [
// Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Beginning - Min",
"display" : "Protein Concentration - Beginning - Min"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 8.00,
"unit" : "mg/mL"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Beginning - Max",
"display" : "Protein Concentration - Beginning - Max"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 8.05,
"unit" : "mg/mL"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Middle - Min",
"display" : "Protein Concentration - Middle - Min"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 8.10,
"unit" : "mg/mL"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - Middle - Max",
"display" : "Protein Concentration - Middle - Max"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 8.15,
"unit" : "mg/mL"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - End - Min",
"display" : "Protein Concentration - End - Min"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 8.2,
"unit" : "mg/mL"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Protein Concentration - End - Max",
"display" : "Protein Concentration - End - Max"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 8.25,
"unit" : "mg/mL"
}
}
]
}
},
{
"fullUrl" : "urn:uuid:54aa47fd-9964-5f97-6495-b2bec8f162e8",
"resource" : {
"resourceType" : "Observation",
"id" : "54aa47fd-9964-5f97-6495-b2bec8f162e8",
"text" : // polysorbate2
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"54aa47fd-9964-5f97-6495-b2bec8f162e8\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "54aa47fd-9964-5f97-6495-b2bec8f162e8" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_74515b3c-5234-448a-9c19-939ce1958524\">See above (ObservationDefinition/74515b3c-5234-448a-9c19-939ce1958524)</a></p><p><b>status</b>: final</p><p><b>code</b>: Polysorbate 80 concentration (% w/v) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Polysorbate 80 concentration (% w/v))</span></p><p><b>subject</b>: <a href=\"#Medication_a9dfda53-734b-045f-7ae4-94a6281d53bc\">See above (Medication/a9dfda53-734b-045f-7ae4-94a6281d53bc)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: Polysorbate 80 concentration - Beginning - Min <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Polysorbate 80 concentration - Beginning - Min)</span></p><p><b>value</b>: 1.0 % w/v</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Polysorbate 80 concentration - Beginning - Max <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Polysorbate 80 concentration - Beginning - Max)</span></p><p><b>value</b>: 1.05 % w/v</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Polysorbate 80 concentration - Middle - Min <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Polysorbate 80 concentration - Middle - Min)</span></p><p><b>value</b>: 1.10 % w/v</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Polysorbate 80 concentration - Middle - Max <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Polysorbate 80 concentration - Middle - Max)</span></p><p><b>value</b>: 1.15 % w/v</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Polysorbate 80 concentration - End - Min <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Polysorbate 80 concentration - End - Min)</span></p><p><b>value</b>: 1.2 % w/v</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Polysorbate 80 concentration - End - Max <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Polysorbate 80 concentration - End - Max)</span></p><p><b>value</b>: 1.25 % w/v</p></blockquote></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/74515b3c-5234-448a-9c19-939ce1958524"
},
"status" : "final",
"code" : // ObservationDefinition/Polysorbate80Concentration
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Polysorbate 80 concentration (% w/v)",
"display" : "Polysorbate 80 concentration (% w/v)"
}
]
},
"subject" : {
"reference" : "Medication/a9dfda53-734b-045f-7ae4-94a6281d53bc"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-actual-batch-2
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"component" : [
// Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Polysorbate 80 concentration - Beginning - Min",
"display" : "Polysorbate 80 concentration - Beginning - Min"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 1.0,
"unit" : "% w/v"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Polysorbate 80 concentration - Beginning - Max",
"display" : "Polysorbate 80 concentration - Beginning - Max"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 1.05,
"unit" : "% w/v"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Polysorbate 80 concentration - Middle - Min",
"display" : "Polysorbate 80 concentration - Middle - Min"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 1.10,
"unit" : "% w/v"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Polysorbate 80 concentration - Middle - Max",
"display" : "Polysorbate 80 concentration - Middle - Max"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 1.15,
"unit" : "% w/v"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Polysorbate 80 concentration - End - Min",
"display" : "Polysorbate 80 concentration - End - Min"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 1.2,
"unit" : "% w/v"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Polysorbate 80 concentration - End - Max",
"display" : "Polysorbate 80 concentration - End - Max"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 1.25,
"unit" : "% w/v"
}
}
]
}
},
{
"fullUrl" : "urn:uuid:54aa47fd-9964-5f97-6495-b2bec7f161e8",
"resource" : {
"resourceType" : "Observation",
"id" : "54aa47fd-9964-5f97-6495-b2bec7f161e8",
"text" : // growthPromotion1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"54aa47fd-9964-5f97-6495-b2bec7f161e8\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "54aa47fd-9964-5f97-6495-b2bec7f161e8" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_64515b3c-5134-448a-9d19-939ce1958524\">See above (ObservationDefinition/64515b3c-5134-448a-9d19-939ce1958524)</a></p><p><b>status</b>: final</p><p><b>code</b>: Growth Promotion <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#GrowthPromotion)</span></p><p><b>subject</b>: <a href=\"#Procedure_44aa47fd-8964-5f96-8495-b2bec7f161a8\">See above (Procedure/44aa47fd-8964-5f96-8495-b2bec7f161a8)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: Growth Promotion - Beginning <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Growth Promotion - Beginning)</span></p><p><b>value</b>: Pass</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Growth Promotion - End <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Growth Promotion - End)</span></p><p><b>value</b>: Pass</p></blockquote></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/64515b3c-5134-448a-9d19-939ce1958524"
},
"status" : "final",
"code" : // ObservationDefinition/GrowthPromotion
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "GrowthPromotion",
"display" : "Growth Promotion"
}
]
},
"subject" : {
"reference" : "Procedure/44aa47fd-8964-5f96-8495-b2bec7f161a8"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Procedure/procedure-drug-pq-ex1
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"component" : [
// Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Growth Promotion - Beginning",
"display" : "Growth Promotion - Beginning"
}
]
},
"valueString" : "Pass"
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Growth Promotion - End",
"display" : "Growth Promotion - End"
}
]
},
"valueString" : "Pass"
}
]
}
},
{
"fullUrl" : "urn:uuid:64aa47fd-8964-5f98-6495-b2bec7f161e8",
"resource" : {
"resourceType" : "Observation",
"id" : "64aa47fd-8964-5f98-6495-b2bec7f161e8",
"text" : // growthPromotion2
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"64aa47fd-8964-5f98-6495-b2bec7f161e8\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "64aa47fd-8964-5f98-6495-b2bec7f161e8" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_64515b3c-5134-448a-9d19-939ce1958524\">See above (ObservationDefinition/64515b3c-5134-448a-9d19-939ce1958524)</a></p><p><b>status</b>: final</p><p><b>code</b>: Growth Promotion <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#GrowthPromotion)</span></p><p><b>subject</b>: <a href=\"#Procedure_44aa47fd-8964-5f96-6495-b2bec7f162a8\">See above (Procedure/44aa47fd-8964-5f96-6495-b2bec7f162a8)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: Growth Promotion - Beginning <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Growth Promotion - Beginning)</span></p><p><b>value</b>: Pass</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Growth Promotion - End <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Growth Promotion - End)</span></p><p><b>value</b>: Pass</p></blockquote></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/64515b3c-5134-448a-9d19-939ce1958524"
},
"status" : "final",
"code" : // ObservationDefinition/GrowthPromotion
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "GrowthPromotion",
"display" : "Growth Promotion"
}
]
},
"subject" : {
"reference" : "Procedure/44aa47fd-8964-5f96-6495-b2bec7f162a8"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Procedure/procedure-run-2
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"component" : [
// Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Growth Promotion - Beginning",
"display" : "Growth Promotion - Beginning"
}
]
},
"valueString" : "Pass"
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Growth Promotion - End",
"display" : "Growth Promotion - End"
}
]
},
"valueString" : "Pass"
}
]
}
},
{
"fullUrl" : "urn:uuid:74aa47fd-8964-5f99-7495-b2bec7f161e8",
"resource" : {
"resourceType" : "Observation",
"id" : "74aa47fd-8964-5f99-7495-b2bec7f161e8",
"text" : // growthPromotion3
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"74aa47fd-8964-5f99-7495-b2bec7f161e8\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "74aa47fd-8964-5f99-7495-b2bec7f161e8" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_64515b3c-5134-448a-9d19-939ce1958524\">See above (ObservationDefinition/64515b3c-5134-448a-9d19-939ce1958524)</a></p><p><b>status</b>: final</p><p><b>code</b>: Growth Promotion <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#GrowthPromotion)</span></p><p><b>subject</b>: <a href=\"#Procedure_44aa47fd-8964-5f96-6495-b2bec7f163a8\">See above (Procedure/44aa47fd-8964-5f96-6495-b2bec7f163a8)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: Growth Promotion - Beginning <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Growth Promotion - Beginning)</span></p><p><b>value</b>: Pass</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Growth Promotion - End <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Growth Promotion - End)</span></p><p><b>value</b>: Fail</p></blockquote></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/64515b3c-5134-448a-9d19-939ce1958524"
},
"status" : "final",
"code" : // ObservationDefinition/GrowthPromotion
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "GrowthPromotion",
"display" : "Growth Promotion"
}
]
},
"subject" : {
"reference" : "Procedure/44aa47fd-8964-5f96-6495-b2bec7f163a8"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Procedure/procedure-run-3
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"component" : [
// Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Growth Promotion - Beginning",
"display" : "Growth Promotion - Beginning"
}
]
},
"valueString" : "Pass"
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Growth Promotion - End",
"display" : "Growth Promotion - End"
}
]
},
"valueString" : "Fail"
}
]
}
},
{
"fullUrl" : "urn:uuid:44aa47fd-8964-5f96-8495-b2bec7f161a8",
"resource" : {
"resourceType" : "Procedure",
"id" : "44aa47fd-8964-5f96-8495-b2bec7f161a8",
"text" : // procedure-drug-pq-ex1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Procedure</b><a name=\"44aa47fd-8964-5f96-8495-b2bec7f161a8\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Procedure "44aa47fd-8964-5f96-8495-b2bec7f161a8" </p></div><p><b>identifier</b>: id:\u00a0Run 1</p><p><b>status</b>: completed</p><p><b>code</b>: Media Challenge Run <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#MediaChallengeRun)</span></p><p><b>subject</b>: <span>: Drug product</span></p></div>"
},
"identifier" : [
// <meta>
<profile value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Procedure-drug-pq"/>
</meta>
{
"value" : "Run 1"
}
],
"status" : "completed",
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "MediaChallengeRun",
"display" : "Media Challenge Run"
}
]
},
"subject" : // only needed to suppress IG warning
{
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/alternate-reference",
"valueReference" : {
"reference" : "MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5"
}
}
],
"display" : "Drug product"
}
}
},
// MedicinalProductDefinition/medicinalproductdefinition-drug-product-pq-ex1
{
"fullUrl" : "urn:uuid:44aa47fd-8964-5f96-6495-b2bec7f162a8",
"resource" : {
"resourceType" : "Procedure",
"id" : "44aa47fd-8964-5f96-6495-b2bec7f162a8",
"text" : // procedure-run-2
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Procedure</b><a name=\"44aa47fd-8964-5f96-6495-b2bec7f162a8\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Procedure "44aa47fd-8964-5f96-6495-b2bec7f162a8" </p></div><p><b>identifier</b>: id:\u00a0Run 2</p><p><b>status</b>: completed</p><p><b>code</b>: Media Challenge Run <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#MediaChallengeRun)</span></p><p><b>subject</b>: <span>: Drug product</span></p></div>"
},
"identifier" : [
{
"value" : "Run 2"
}
],
"status" : "completed",
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "MediaChallengeRun",
"display" : "Media Challenge Run"
}
]
},
"subject" : // only needed to suppress IG warning
{
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/alternate-reference",
"valueReference" : {
"reference" : "MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5"
}
}
],
"display" : "Drug product"
}
}
},
// MedicinalProductDefinition/medicinalproductdefinition-drug-product-pq-ex1
{
"fullUrl" : "urn:uuid:44aa47fd-8964-5f96-6495-b2bec7f163a8",
"resource" : {
"resourceType" : "Procedure",
"id" : "44aa47fd-8964-5f96-6495-b2bec7f163a8",
"text" : // procedure-run-3
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Procedure</b><a name=\"44aa47fd-8964-5f96-6495-b2bec7f163a8\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Procedure "44aa47fd-8964-5f96-6495-b2bec7f163a8" </p></div><p><b>identifier</b>: id:\u00a0Run 3</p><p><b>status</b>: completed</p><p><b>code</b>: Media Challenge Run <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#MediaChallengeRun)</span></p><p><b>subject</b>: <span>: Drug product</span></p></div>"
},
"identifier" : [
{
"value" : "Run 3"
}
],
"status" : "completed",
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "MediaChallengeRun",
"display" : "Media Challenge Run"
}
]
},
"subject" : // only needed to suppress IG warning
{
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/alternate-reference",
"valueReference" : {
"reference" : "MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5"
}
}
],
"display" : "Drug product"
}
}
},
// MedicinalProductDefinition/medicinalproductdefinition-drug-product-pq-ex1
{
"fullUrl" : "urn:uuid:44aa47fd-8964-5f96-6495-c2bec7f163a8",
"resource" : {
"resourceType" : "Procedure",
"id" : "44aa47fd-8964-5f96-6495-c2bec7f163a8",
"text" : // procedure-drug-pq-ex2
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Procedure</b><a name=\"44aa47fd-8964-5f96-6495-c2bec7f163a8\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Procedure "44aa47fd-8964-5f96-6495-c2bec7f163a8" </p></div><p><b>status</b>: completed</p><p><b>code</b>: Lyophilization Homogeneneity <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#LyophilizationHomogeneneity)</span></p><p><b>subject</b>: <span>: Drug batch</span></p><h3>Performers</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Actor</b></td></tr><tr><td style=\"display: none\">*</td><td><a name=\"device-nosubject\"> </a><blockquote><p/><p><a name=\"device-nosubject\"> </a></p><h3>Definitions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#DDLyo1\">#DDLyo1</a></td></tr></table></blockquote></td></tr></table><hr/><blockquote><p><b>Generated Narrative: Device #device-nosubject</b><a name=\"device-nosubject\"> </a></p><h3>Definitions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#DDLyo1\">#DDLyo1</a></td></tr></table></blockquote><hr/><blockquote><p><b>Generated Narrative: DeviceDefinition #DDLyo1</b><a name=\"DDLyo1\"> </a></p><p><b>identifier</b>: id:\u00a0Lyo 1</p></blockquote></div>"
},
"contained" : [
{
"resourceType" : "Device",
"id" : "device-nosubject",
"definition" : {
"reference" : {
"reference" : "#DDLyo1"
}
}
},
{
"resourceType" : "DeviceDefinition",
"id" : "DDLyo1",
"identifier" : [
{
"value" : "Lyo 1"
}
]
}
],
"status" : "completed",
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "LyophilizationHomogeneneity",
"display" : "Lyophilization Homogeneneity"
}
]
},
"subject" : // only needed to suppress IG warning
{
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/alternate-reference",
"valueReference" : {
"reference" : "Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51"
}
}
],
"display" : "Drug batch"
},
"performer" : [
// Medication/medication-batch-information-drug-pq-ex1
{
"actor" : {
"reference" : "#device-nosubject",
"display" : "Lyo 1"
}
}
]
}
},
{
"fullUrl" : "urn:uuid:44aa47fd-8964-5f96-6495-b2bec7f161e7",
"resource" : {
"resourceType" : "Observation",
"id" : "44aa47fd-8964-5f96-6495-b2bec7f161e7",
"text" : // postFiltrationFilterIntegrity1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"44aa47fd-8964-5f96-6495-b2bec7f161e7\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "44aa47fd-8964-5f96-6495-b2bec7f161e7" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_75515b3c-5134-448a-9c19-949ce1958434\">See above (ObservationDefinition/75515b3c-5134-448a-9c19-949ce1958434)</a></p><p><b>status</b>: final</p><p><b>code</b>: Post-filtration Filter Integrity (psig) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Post-filtration Filter Integrity (psig))</span></p><p><b>subject</b>: <a href=\"#Medication_339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51\">See above (Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 280 mOsm/kg</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Test Success <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#test-success)</span></td><td>Pass <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/75515b3c-5134-448a-9c19-949ce1958434"
},
"status" : "final",
"code" : // ObservationDefinition/PostFiltrationFilterIntegrity
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Post-filtration Filter Integrity (psig)",
"display" : "Post-filtration Filter Integrity (psig)"
}
],
"text" : "Post-filtration Filter Integrity (psig)"
},
"subject" : {
"reference" : "Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-batch-information-drug-pq-ex1
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 280,
"unit" : "mOsm/kg"
},
"component" : [
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "test-success",
"display" : "Test Success"
}
]
},
"valueCodeableConcept" : // consider a boolean
{
"text" : "Pass"
}
}
]
}
},
{
"fullUrl" : "urn:uuid:44aa47fd-8964-4f96-6495-b2bec7f161e7",
"resource" : {
"resourceType" : "Observation",
"id" : "44aa47fd-8964-4f96-6495-b2bec7f161e7",
"text" : // osmolality1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"44aa47fd-8964-4f96-6495-b2bec7f161e7\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "44aa47fd-8964-4f96-6495-b2bec7f161e7" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_64525a3c-5034-448a-9c19-938ce1958424\">See above (ObservationDefinition/64525a3c-5034-448a-9c19-938ce1958424)</a></p><p><b>status</b>: final</p><p><b>code</b>: osmolality <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Osmolality "Osmolality")</span></p><p><b>subject</b>: <a href=\"#Medication_339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51\">See above (Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 280 mOsm/kg</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/64525a3c-5034-448a-9c19-938ce1958424"
},
"status" : "final",
"code" : // ObservationDefinition/Osmolality
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Osmolality",
"display" : "Osmolality"
}
],
"text" : "osmolality"
},
"subject" : {
"reference" : "Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-batch-information-drug-pq-ex1
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 280,
"unit" : "mOsm/kg"
}
}
},
{
"fullUrl" : "urn:uuid:54aa47fd-8964-4f96-6495-b2bec7f162e7",
"resource" : {
"resourceType" : "Observation",
"id" : "54aa47fd-8964-4f96-6495-b2bec7f162e7",
"text" : // osmolality2
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"54aa47fd-8964-4f96-6495-b2bec7f162e7\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "54aa47fd-8964-4f96-6495-b2bec7f162e7" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_64525a3c-5034-448a-9c19-938ce1958424\">See above (ObservationDefinition/64525a3c-5034-448a-9c19-938ce1958424)</a></p><p><b>status</b>: final</p><p><b>code</b>: osmolality <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Osmolality "Osmolality")</span></p><p><b>subject</b>: <a href=\"#Medication_a9dfda53-734b-045f-7ae4-94a6281d53bc\">See above (Medication/a9dfda53-734b-045f-7ae4-94a6281d53bc)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 285 mOsm/kg</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/64525a3c-5034-448a-9c19-938ce1958424"
},
"status" : "final",
"code" : // ObservationDefinition/Osmolality
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Osmolality",
"display" : "Osmolality"
}
],
"text" : "osmolality"
},
"subject" : {
"reference" : "Medication/a9dfda53-734b-045f-7ae4-94a6281d53bc"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-actual-batch-2
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 285,
"unit" : "mOsm/kg"
}
}
},
{
"fullUrl" : "urn:uuid:54aa48fd-8964-4f96-6495-b2bec7f163e7",
"resource" : {
"resourceType" : "Observation",
"id" : "54aa48fd-8964-4f96-6495-b2bec7f163e7",
"text" : // osmolality3
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"54aa48fd-8964-4f96-6495-b2bec7f163e7\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "54aa48fd-8964-4f96-6495-b2bec7f163e7" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_64525a3c-5034-448a-9c19-938ce1958424\">See above (ObservationDefinition/64525a3c-5034-448a-9c19-938ce1958424)</a></p><p><b>status</b>: final</p><p><b>code</b>: osmolality <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Osmolality "Osmolality")</span></p><p><b>subject</b>: <a href=\"#Medication_c6f5fadd-62e6-3a01-93d9-b3b182f67d06\">See above (Medication/c6f5fadd-62e6-3a01-93d9-b3b182f67d06)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 290 mOsm/kg</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/64525a3c-5034-448a-9c19-938ce1958424"
},
"status" : "final",
"code" : // ObservationDefinition/Osmolality
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Osmolality",
"display" : "Osmolality"
}
],
"text" : "osmolality"
},
"subject" : {
"reference" : "Medication/c6f5fadd-62e6-3a01-93d9-b3b182f67d06"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-actual-batch-3
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 290,
"unit" : "mOsm/kg"
}
}
},
{
"fullUrl" : "urn:uuid:44ba47fd-8964-4f96-6495-b2bec7f161e8",
"resource" : {
"resourceType" : "Observation",
"id" : "44ba47fd-8964-4f96-6495-b2bec7f161e8",
"text" : // residualMoisture1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"44ba47fd-8964-4f96-6495-b2bec7f161e8\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "44ba47fd-8964-4f96-6495-b2bec7f161e8" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_fc27b6d6-9fe2-91c2-2d16-47cb5b295e72\">See above (ObservationDefinition/fc27b6d6-9fe2-91c2-2d16-47cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: Residual Moisture (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Residual Moisture "Residual Moisture")</span></p><p><b>subject</b>: <a href=\"#Medication_339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51\">See above (Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: Residual Moisture - Min <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Residual Moisture - Min)</span></p><p><b>value</b>: 3.1 %</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Residual Moisture - Max <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Residual Moisture - Max)</span></p><p><b>value</b>: 3.2 %</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Number of Samples <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SAMP)</span></p><p><b>value</b>: 2</p></blockquote></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/fc27b6d6-9fe2-91c2-2d16-47cb5b295e72"
},
"status" : "final",
"code" : // ObservationDefinition/ResidualMoisture
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Residual Moisture",
"display" : "Residual Moisture"
}
],
"text" : "Residual Moisture (%)"
},
"subject" : {
"reference" : "Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-batch-information-drug-pq-ex1
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"component" : [
// Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Residual Moisture - Min",
"display" : "Residual Moisture - Min"
}
]
},
"valueQuantity" : {
"value" : 3.1,
"unit" : "%"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Residual Moisture - Max",
"display" : "Residual Moisture - Max"
}
]
},
"valueQuantity" : {
"value" : 3.2,
"unit" : "%"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SAMP",
"display" : "Number of Samples"
}
]
},
"valueInteger" : 2
}
]
}
},
{
"fullUrl" : "urn:uuid:44ba47fd-9964-4f96-6495-b2bec7f161e8",
"resource" : {
"resourceType" : "Observation",
"id" : "44ba47fd-9964-4f96-6495-b2bec7f161e8",
"text" : // residualMoisture2
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"44ba47fd-9964-4f96-6495-b2bec7f161e8\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "44ba47fd-9964-4f96-6495-b2bec7f161e8" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_fc27b6d6-9fe2-91c2-2d16-47cb5b295e72\">See above (ObservationDefinition/fc27b6d6-9fe2-91c2-2d16-47cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: Residual Moisture (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Residual Moisture "Residual Moisture")</span></p><p><b>subject</b>: <a href=\"#Medication_a9dfda53-734b-045f-7ae4-94a6281d53bc\">See above (Medication/a9dfda53-734b-045f-7ae4-94a6281d53bc)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 4.2 %</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Number of Samples <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SAMP)</span></td><td>3</td></tr></table></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/fc27b6d6-9fe2-91c2-2d16-47cb5b295e72"
},
"status" : "final",
"code" : // ObservationDefinition/ResidualMoisture
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Residual Moisture",
"display" : "Residual Moisture"
}
],
"text" : "Residual Moisture (%)"
},
"subject" : {
"reference" : "Medication/a9dfda53-734b-045f-7ae4-94a6281d53bc"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-actual-batch-2
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 4.2,
"unit" : "%"
},
"component" : [
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SAMP",
"display" : "Number of Samples"
}
]
},
"valueInteger" : 3
}
]
}
},
{
"fullUrl" : "urn:uuid:44ba47fd-9964-4f96-6496-b2bec7f161e8",
"resource" : {
"resourceType" : "Observation",
"id" : "44ba47fd-9964-4f96-6496-b2bec7f161e8",
"text" : // residualMoisture3
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"44ba47fd-9964-4f96-6496-b2bec7f161e8\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "44ba47fd-9964-4f96-6496-b2bec7f161e8" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_fc27b6d6-9fe2-91c2-2d16-47cb5b295e72\">See above (ObservationDefinition/fc27b6d6-9fe2-91c2-2d16-47cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: Residual Moisture (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Residual Moisture "Residual Moisture")</span></p><p><b>subject</b>: <a href=\"#Medication_c6f5fadd-62e6-3a01-93d9-b3b182f67d06\">See above (Medication/c6f5fadd-62e6-3a01-93d9-b3b182f67d06)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 4.4 %</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Number of Samples <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SAMP)</span></td><td>3</td></tr></table></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/fc27b6d6-9fe2-91c2-2d16-47cb5b295e72"
},
"status" : "final",
"code" : // ObservationDefinition/ResidualMoisture
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Residual Moisture",
"display" : "Residual Moisture"
}
],
"text" : "Residual Moisture (%)"
},
"subject" : {
"reference" : "Medication/c6f5fadd-62e6-3a01-93d9-b3b182f67d06"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-actual-batch-3
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 4.4,
"unit" : "%"
},
"component" : [
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SAMP",
"display" : "Number of Samples"
}
]
},
"valueInteger" : 3
}
]
}
},
{
"fullUrl" : "urn:uuid:44ba47fd-8964-4f96-6495-b2bec7f161e7",
"resource" : {
"resourceType" : "Observation",
"id" : "44ba47fd-8964-4f96-6495-b2bec7f161e7",
"text" : // SE-UHPLCMainPeak1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"44ba47fd-8964-4f96-6495-b2bec7f161e7\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "44ba47fd-8964-4f96-6495-b2bec7f161e7" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_64525a3d-5034-448a-9c19-938ce1958424\">See above (ObservationDefinition/64525a3d-5034-448a-9c19-938ce1958424)</a></p><p><b>status</b>: final</p><p><b>code</b>: SE-UHPLC Main Peak (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCMainPeak "SE-UHPLC Main Peak")</span></p><p><b>subject</b>: <a href=\"#Medication_339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51\">See above (Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: SE-UHPLC Main Peak - Beginning <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLC Main Peak - Beginning)</span></p><p><b>value</b>: 8.0 %</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: SE-UHPLC Main Peak - End <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLC Main Peak - End)</span></p><p><b>value</b>: 8.5 %</p></blockquote></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/64525a3d-5034-448a-9c19-938ce1958424"
},
"status" : "final",
"code" : // ObservationDefinition/SE-UHPLCMainPeak
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCMainPeak",
"display" : "SE-UHPLC Main Peak"
}
],
"text" : "SE-UHPLC Main Peak (%)"
},
"subject" : {
"reference" : "Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-batch-information-drug-pq-ex1
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"component" : [
// Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLC Main Peak - Beginning",
"display" : "SE-UHPLC Main Peak - Beginning"
}
]
},
"valueQuantity" : {
"value" : 8.0,
"unit" : "%"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLC Main Peak - End",
"display" : "SE-UHPLC Main Peak - End"
}
]
},
"valueQuantity" : {
"value" : 8.5,
"unit" : "%"
}
}
]
}
},
{
"fullUrl" : "urn:uuid:54ca47fd-8964-4f96-6495-b2bec7f162e7",
"resource" : {
"resourceType" : "Observation",
"id" : "54ca47fd-8964-4f96-6495-b2bec7f162e7",
"text" : // SE-UHPLCMainPeak2
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"54ca47fd-8964-4f96-6495-b2bec7f162e7\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "54ca47fd-8964-4f96-6495-b2bec7f162e7" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_64525a3d-5034-448a-9c19-938ce1958424\">See above (ObservationDefinition/64525a3d-5034-448a-9c19-938ce1958424)</a></p><p><b>status</b>: final</p><p><b>code</b>: SE-UHPLC Main Peak (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCMainPeak "SE-UHPLC Main Peak")</span></p><p><b>subject</b>: <a href=\"#Medication_a9dfda53-734b-045f-7ae4-94a6281d53bc\">See above (Medication/a9dfda53-734b-045f-7ae4-94a6281d53bc)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: SE-UHPLC Main Peak - Beginning <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLC Main Peak - Beginning)</span></p><p><b>value</b>: 9.0 %</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: SE-UHPLC Main Peak - End <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLC Main Peak - End)</span></p><p><b>value</b>: 9.5 %</p></blockquote></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/64525a3d-5034-448a-9c19-938ce1958424"
},
"status" : "final",
"code" : // ObservationDefinition/SE-UHPLCMainPeak
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCMainPeak",
"display" : "SE-UHPLC Main Peak"
}
],
"text" : "SE-UHPLC Main Peak (%)"
},
"subject" : {
"reference" : "Medication/a9dfda53-734b-045f-7ae4-94a6281d53bc"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-actual-batch-2
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"component" : [
// Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLC Main Peak - Beginning",
"display" : "SE-UHPLC Main Peak - Beginning"
}
]
},
"valueQuantity" : {
"value" : 9.0,
"unit" : "%"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLC Main Peak - End",
"display" : "SE-UHPLC Main Peak - End"
}
]
},
"valueQuantity" : {
"value" : 9.5,
"unit" : "%"
}
}
]
}
},
{
"fullUrl" : "urn:uuid:54da48fd-8964-4f96-6495-b2bec7f163e7",
"resource" : {
"resourceType" : "Observation",
"id" : "54da48fd-8964-4f96-6495-b2bec7f163e7",
"text" : // SE-UHPLCMainPeak3
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"54da48fd-8964-4f96-6495-b2bec7f163e7\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "54da48fd-8964-4f96-6495-b2bec7f163e7" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_64525a3d-5034-448a-9c19-938ce1958424\">See above (ObservationDefinition/64525a3d-5034-448a-9c19-938ce1958424)</a></p><p><b>status</b>: final</p><p><b>code</b>: SE-UHPLC Main Peak (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCMainPeak "SE-UHPLC Main Peak")</span></p><p><b>subject</b>: <a href=\"#Medication_c6f5fadd-62e6-3a01-93d9-b3b182f67d06\">See above (Medication/c6f5fadd-62e6-3a01-93d9-b3b182f67d06)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: SE-UHPLC Main Peak - Beginning <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLC Main Peak - Beginning)</span></p><p><b>value</b>: 10.0 %</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: SE-UHPLC Main Peak - End <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLC Main Peak - End)</span></p><p><b>value</b>: 10.5 %</p></blockquote></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/64525a3d-5034-448a-9c19-938ce1958424"
},
"status" : "final",
"code" : // ObservationDefinition/SE-UHPLCMainPeak
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCMainPeak",
"display" : "SE-UHPLC Main Peak"
}
],
"text" : "SE-UHPLC Main Peak (%)"
},
"subject" : {
"reference" : "Medication/c6f5fadd-62e6-3a01-93d9-b3b182f67d06"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-actual-batch-3
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"component" : [
// Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLC Main Peak - Beginning",
"display" : "SE-UHPLC Main Peak - Beginning"
}
]
},
"valueQuantity" : {
"value" : 10.0,
"unit" : "%"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLC Main Peak - End",
"display" : "SE-UHPLC Main Peak - End"
}
]
},
"valueQuantity" : {
"value" : 10.5,
"unit" : "%"
}
}
]
}
},
{
"fullUrl" : "urn:uuid:44ba47fd-8964-5f96-6495-b2bec7f161e7",
"resource" : {
"resourceType" : "Observation",
"id" : "44ba47fd-8964-5f96-6495-b2bec7f161e7",
"text" : // SE-UHPLCMainPeakGraph1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"44ba47fd-8964-5f96-6495-b2bec7f161e7\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "44ba47fd-8964-5f96-6495-b2bec7f161e7" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_64525a4d-5034-448a-9c19-938ce1958424\">See above (ObservationDefinition/64525a4d-5034-448a-9c19-938ce1958424)</a></p><p><b>status</b>: final</p><p><b>code</b>: SE-UHPLC Main Peak (Graph) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCMainPeak "SE-UHPLC Main Peak")</span></p><p><b>subject</b>: <a href=\"#Medication_339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51\">See above (Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: </p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/64525a4d-5034-448a-9c19-938ce1958424"
},
"status" : "final",
"code" : // ObservationDefinition/SE-UHPLCMainPeakGraph
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCMainPeak",
"display" : "SE-UHPLC Main Peak"
}
],
"text" : "SE-UHPLC Main Peak (Graph)"
},
"subject" : {
"reference" : "Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-batch-information-drug-pq-ex1
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueAttachment" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"contentType" : "image/png",
"data" : 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"
}
}
},
{
"fullUrl" : "urn:uuid:54ba47fd-8964-4f96-6495-b2bec7f161e7",
"resource" : // component> these are now done in another non-batch specific obs
{
"resourceType" : "Observation",
"id" : "54ba47fd-8964-4f96-6495-b2bec7f161e7",
"text" : // SE-UHPLCMainPeakLyoph1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"54ba47fd-8964-4f96-6495-b2bec7f161e7\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "54ba47fd-8964-4f96-6495-b2bec7f161e7" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_64525a3d-5134-448a-9c19-938ce1958424\">See above (ObservationDefinition/64525a3d-5134-448a-9c19-938ce1958424)</a></p><p><b>status</b>: final</p><p><b>code</b>: SE-UHPLC Main Peak (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCMainPeak "SE-UHPLC Main Peak")</span></p><p><b>subject</b>: <a href=\"#Medication_339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51\">See above (Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 91 %</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/64525a3d-5134-448a-9c19-938ce1958424"
},
"status" : "final",
"code" : // ObservationDefinition/SE-UHPLCMainPeakLyoph
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCMainPeak",
"display" : "SE-UHPLC Main Peak"
}
],
"text" : "SE-UHPLC Main Peak (%)"
},
"subject" : {
"reference" : "Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-batch-information-drug-pq-ex1
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 91,
"unit" : "%"
}
}
},
{
"fullUrl" : "urn:uuid:54ba47fd-8964-4f96-6495-b2bec7f161e8",
"resource" : // component> these are now done in another non-batch specific obs
{
"resourceType" : "Observation",
"id" : "54ba47fd-8964-4f96-6495-b2bec7f161e8",
"text" : // SE-UHPLCMainPeakLyoph2
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"54ba47fd-8964-4f96-6495-b2bec7f161e8\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "54ba47fd-8964-4f96-6495-b2bec7f161e8" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_64525a3d-5134-448a-9c19-938ce1958424\">See above (ObservationDefinition/64525a3d-5134-448a-9c19-938ce1958424)</a></p><p><b>status</b>: final</p><p><b>code</b>: SE-UHPLC Main Peak (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCMainPeak "SE-UHPLC Main Peak")</span></p><p><b>subject</b>: <a href=\"#Medication_a9dfda53-734b-045f-7ae4-94a6281d53bc\">See above (Medication/a9dfda53-734b-045f-7ae4-94a6281d53bc)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 89 %</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/64525a3d-5134-448a-9c19-938ce1958424"
},
"status" : "final",
"code" : // ObservationDefinition/SE-UHPLCMainPeakLyoph
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCMainPeak",
"display" : "SE-UHPLC Main Peak"
}
],
"text" : "SE-UHPLC Main Peak (%)"
},
"subject" : {
"reference" : "Medication/a9dfda53-734b-045f-7ae4-94a6281d53bc"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-actual-batch-2
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 89,
"unit" : "%"
}
}
},
{
"fullUrl" : "urn:uuid:54ba47fd-8964-4f96-6495-b2bec7f161e9",
"resource" : // component> these are now done in another non-batch specific obs
{
"resourceType" : "Observation",
"id" : "54ba47fd-8964-4f96-6495-b2bec7f161e9",
"text" : // SE-UHPLCMainPeakLyoph3
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"54ba47fd-8964-4f96-6495-b2bec7f161e9\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "54ba47fd-8964-4f96-6495-b2bec7f161e9" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_64525a3d-5134-448a-9c19-938ce1958424\">See above (ObservationDefinition/64525a3d-5134-448a-9c19-938ce1958424)</a></p><p><b>status</b>: final</p><p><b>code</b>: SE-UHPLC Main Peak (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCMainPeak "SE-UHPLC Main Peak")</span></p><p><b>subject</b>: <a href=\"#Medication_c6f5fadd-62e6-3a01-93d9-b3b182f67d06\">See above (Medication/c6f5fadd-62e6-3a01-93d9-b3b182f67d06)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 92 %</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/64525a3d-5134-448a-9c19-938ce1958424"
},
"status" : "final",
"code" : // ObservationDefinition/SE-UHPLCMainPeakLyoph
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCMainPeak",
"display" : "SE-UHPLC Main Peak"
}
],
"text" : "SE-UHPLC Main Peak (%)"
},
"subject" : {
"reference" : "Medication/c6f5fadd-62e6-3a01-93d9-b3b182f67d06"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-actual-batch-3
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 92,
"unit" : "%"
}
}
},
{
"fullUrl" : "urn:uuid:54ba48fd-8964-4f96-6495-b2bec7f161e7",
"resource" : {
"resourceType" : "Observation",
"id" : "54ba48fd-8964-4f96-6495-b2bec7f161e7",
"text" : // SE-UHPLCMainPeakLyophConclusionObs
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"54ba48fd-8964-4f96-6495-b2bec7f161e7\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "54ba48fd-8964-4f96-6495-b2bec7f161e7" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_64525a3d-5134-448a-9c19-938ce1958424\">See above (ObservationDefinition/64525a3d-5134-448a-9c19-938ce1958424)</a></p><p><b>status</b>: final</p><p><b>code</b>: SE-UHPLC Main Peak (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCMainPeak "SE-UHPLC Main Peak")</span></p><p><b>subject</b>: <span>: Product</span></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: Number of Samples <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SAMP)</span></p><p><b>value</b>: 12</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: SE-UHPLC Main Peak Conclusion <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCMainPeak - Conclusion "SE-UHPLC Main Peak - Conclusion")</span></p><p><b>value</b>: Pass</p></blockquote></div>"
},
"instantiatesReference" : // not using a separate one, % and conclusion are in one definition
{
"reference" : "ObservationDefinition/64525a3d-5134-448a-9c19-938ce1958424"
},
"status" : "final",
"code" : // ObservationDefinition/SE-UHPLCMainPeakLyoph
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCMainPeak",
"display" : "SE-UHPLC Main Peak"
}
],
"text" : "SE-UHPLC Main Peak (%)"
},
"subject" : // note no value here, because the code us the %. But this obs is really about the conclusion
// note no subject here because there is not one specific batch
// added only to keep IG happy
{
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/data-absent-reason",
"valueCode" : "unsupported"
}
],
"display" : "Product"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"component" : [
// Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SAMP",
"display" : "Number of Samples"
}
]
},
"valueInteger" : 12
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCMainPeak - Conclusion",
"display" : "SE-UHPLC Main Peak - Conclusion"
}
],
"text" : "SE-UHPLC Main Peak Conclusion"
},
"valueString" : "Pass"
}
]
}
},
{
"fullUrl" : "urn:uuid:54bb47fd-8964-4f96-6495-b2bec7f161e7",
"resource" : // component> these are now done in another non-batch specific obs
{
"resourceType" : "Observation",
"id" : "54bb47fd-8964-4f96-6495-b2bec7f161e7",
"text" : // SE-UHPLCHMWLyoph1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"54bb47fd-8964-4f96-6495-b2bec7f161e7\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "54bb47fd-8964-4f96-6495-b2bec7f161e7" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_64525a3d-5144-448a-9c19-938ce1958424\">See above (ObservationDefinition/64525a3d-5144-448a-9c19-938ce1958424)</a></p><p><b>status</b>: final</p><p><b>code</b>: SE-UHPLC HMW (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCHMW "SE-UHPLC HMW")</span></p><p><b>subject</b>: <a href=\"#Medication_339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51\">See above (Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 88 %</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/64525a3d-5144-448a-9c19-938ce1958424"
},
"status" : "final",
"code" : // ObservationDefinition/SE-UHPLCHMWLyoph
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCHMW",
"display" : "SE-UHPLC HMW"
}
],
"text" : "SE-UHPLC HMW (%)"
},
"subject" : {
"reference" : "Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-batch-information-drug-pq-ex1
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 88,
"unit" : "%"
}
}
},
{
"fullUrl" : "urn:uuid:54ba47fd-9964-4f96-6495-b2bec7f161e8",
"resource" : // component> these are now done in another non-batch specific obs
{
"resourceType" : "Observation",
"id" : "54ba47fd-9964-4f96-6495-b2bec7f161e8",
"text" : // SE-UHPLCHMWLyoph2
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"54ba47fd-9964-4f96-6495-b2bec7f161e8\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "54ba47fd-9964-4f96-6495-b2bec7f161e8" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_64525a3d-5144-448a-9c19-938ce1958424\">See above (ObservationDefinition/64525a3d-5144-448a-9c19-938ce1958424)</a></p><p><b>status</b>: final</p><p><b>code</b>: SE-UHPLC HMW (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCHMW "SE-UHPLC HMW")</span></p><p><b>subject</b>: <a href=\"#Medication_a9dfda53-734b-045f-7ae4-94a6281d53bc\">See above (Medication/a9dfda53-734b-045f-7ae4-94a6281d53bc)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 93 %</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/64525a3d-5144-448a-9c19-938ce1958424"
},
"status" : "final",
"code" : // ObservationDefinition/SE-UHPLCHMWLyoph
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCHMW",
"display" : "SE-UHPLC HMW"
}
],
"text" : "SE-UHPLC HMW (%)"
},
"subject" : {
"reference" : "Medication/a9dfda53-734b-045f-7ae4-94a6281d53bc"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-actual-batch-2
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 93,
"unit" : "%"
}
}
},
{
"fullUrl" : "urn:uuid:54ba47fe-8964-4f96-6495-b2bec7f161e9",
"resource" : // component> these are now done in another non-batch specific obs
{
"resourceType" : "Observation",
"id" : "54ba47fe-8964-4f96-6495-b2bec7f161e9",
"text" : // SE-UHPLCHMWLyoph3
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"54ba47fe-8964-4f96-6495-b2bec7f161e9\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "54ba47fe-8964-4f96-6495-b2bec7f161e9" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_64525a3d-5144-448a-9c19-938ce1958424\">See above (ObservationDefinition/64525a3d-5144-448a-9c19-938ce1958424)</a></p><p><b>status</b>: final</p><p><b>code</b>: SE-UHPLC HMW (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCHMW "SE-UHPLC HMW")</span></p><p><b>subject</b>: <a href=\"#Medication_c6f5fadd-62e6-3a01-93d9-b3b182f67d06\">See above (Medication/c6f5fadd-62e6-3a01-93d9-b3b182f67d06)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 99 %</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/64525a3d-5144-448a-9c19-938ce1958424"
},
"status" : "final",
"code" : // ObservationDefinition/SE-UHPLCHMWLyoph
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCHMW",
"display" : "SE-UHPLC HMW"
}
],
"text" : "SE-UHPLC HMW (%)"
},
"subject" : {
"reference" : "Medication/c6f5fadd-62e6-3a01-93d9-b3b182f67d06"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-actual-batch-3
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 99,
"unit" : "%"
}
}
},
{
"fullUrl" : "urn:uuid:64ba48fd-8964-4f96-6495-b2bec7f161e7",
"resource" : {
"resourceType" : "Observation",
"id" : "64ba48fd-8964-4f96-6495-b2bec7f161e7",
"text" : // SE-UHPLCHMWLyophConclusionObs
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"64ba48fd-8964-4f96-6495-b2bec7f161e7\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "64ba48fd-8964-4f96-6495-b2bec7f161e7" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_64525a3d-5144-448a-9c19-938ce1958424\">See above (ObservationDefinition/64525a3d-5144-448a-9c19-938ce1958424)</a></p><p><b>status</b>: final</p><p><b>code</b>: SE-UHPLC HMW (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCHMW "SE-UHPLC HMW")</span></p><p><b>subject</b>: <span>: Product</span></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: Number of Samples <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SAMP)</span></p><p><b>value</b>: 9</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: SE-UHPLC HMW Conclusion <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCHMWPeak - Conclusion "SE-UHPLC HMW Peak - Conclusion")</span></p><p><b>value</b>: Fail</p></blockquote></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/64525a3d-5144-448a-9c19-938ce1958424"
},
"status" : "final",
"code" : // ObservationDefinition/SE-UHPLCHMWLyoph
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCHMW",
"display" : "SE-UHPLC HMW"
}
],
"text" : "SE-UHPLC HMW (%)"
},
"subject" : // note no value here, because the code us the %. But this obs is really about the conclusion
// not one specific batch
// no subject because it applies to all the samples
// added only to keep IG happy
{
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/data-absent-reason",
"valueCode" : "unsupported"
}
],
"display" : "Product"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"component" : [
// Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SAMP",
"display" : "Number of Samples"
}
]
},
"valueInteger" : 9
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCHMWPeak - Conclusion",
"display" : "SE-UHPLC HMW Peak - Conclusion"
}
],
"text" : "SE-UHPLC HMW Conclusion"
},
"valueString" : "Fail"
}
]
}
},
{
"fullUrl" : "urn:uuid:44ba47fd-8964-4f97-6495-b2bec7f161e7",
"resource" : {
"resourceType" : "Observation",
"id" : "44ba47fd-8964-4f97-6495-b2bec7f161e7",
"text" : // SE-UHPLCHMW1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"44ba47fd-8964-4f97-6495-b2bec7f161e7\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "44ba47fd-8964-4f97-6495-b2bec7f161e7" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_64525a33-5034-448a-9c19-938ce1958424\">See above (ObservationDefinition/64525a33-5034-448a-9c19-938ce1958424)</a></p><p><b>status</b>: final</p><p><b>code</b>: SE-UHPLC HMW (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCHMW "SE-UHPLC HMW")</span></p><p><b>subject</b>: <a href=\"#Medication_339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51\">See above (Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: SE-UHPLC HMW - Beginning <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCHMW - Beginning)</span></p><p><b>value</b>: 7.0 %</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: SE-UHPLC HMW - End <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCHMW - End)</span></p><p><b>value</b>: 7.5 %</p></blockquote></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/64525a33-5034-448a-9c19-938ce1958424"
},
"status" : "final",
"code" : // ObservationDefinition/SE-UHPLCHMW
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCHMW",
"display" : "SE-UHPLC HMW"
}
],
"text" : "SE-UHPLC HMW (%)"
},
"subject" : {
"reference" : "Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-batch-information-drug-pq-ex1
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"component" : [
// Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCHMW - Beginning",
"display" : "SE-UHPLC HMW - Beginning"
}
]
},
"valueQuantity" : {
"value" : 7.0,
"unit" : "%"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCHMW - End",
"display" : "SE-UHPLC HMW - End"
}
]
},
"valueQuantity" : {
"value" : 7.5,
"unit" : "%"
}
}
]
}
},
{
"fullUrl" : "urn:uuid:54ca47fd-8964-4f98-6495-b2bec7f162e7",
"resource" : {
"resourceType" : "Observation",
"id" : "54ca47fd-8964-4f98-6495-b2bec7f162e7",
"text" : // SE-UHPLCHMW2
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"54ca47fd-8964-4f98-6495-b2bec7f162e7\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "54ca47fd-8964-4f98-6495-b2bec7f162e7" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_64525a33-5034-448a-9c19-938ce1958424\">See above (ObservationDefinition/64525a33-5034-448a-9c19-938ce1958424)</a></p><p><b>status</b>: final</p><p><b>code</b>: SE-UHPLC HMW (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCHMW "SE-UHPLC HMW")</span></p><p><b>subject</b>: <a href=\"#Medication_a9dfda53-734b-045f-7ae4-94a6281d53bc\">See above (Medication/a9dfda53-734b-045f-7ae4-94a6281d53bc)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: SE-UHPLC HMW - Beginning <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCHMW - Beginning)</span></p><p><b>value</b>: 8.0 %</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: SE-UHPLC HMW - End <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCHMW - End)</span></p><p><b>value</b>: 8.5 %</p></blockquote></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/64525a33-5034-448a-9c19-938ce1958424"
},
"status" : "final",
"code" : // ObservationDefinition/SE-UHPLCHMW
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCHMW",
"display" : "SE-UHPLC HMW"
}
],
"text" : "SE-UHPLC HMW (%)"
},
"subject" : {
"reference" : "Medication/a9dfda53-734b-045f-7ae4-94a6281d53bc"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-actual-batch-2
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"component" : [
// Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCHMW - Beginning",
"display" : "SE-UHPLC HMW - Beginning"
}
]
},
"valueQuantity" : {
"value" : 8.0,
"unit" : "%"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCHMW - End",
"display" : "SE-UHPLC HMW - End"
}
]
},
"valueQuantity" : {
"value" : 8.5,
"unit" : "%"
}
}
]
}
},
{
"fullUrl" : "urn:uuid:54da48fd-8964-4f99-6495-b2bec7f163e7",
"resource" : {
"resourceType" : "Observation",
"id" : "54da48fd-8964-4f99-6495-b2bec7f163e7",
"text" : // SE-UHPLCHMW3
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"54da48fd-8964-4f99-6495-b2bec7f163e7\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "54da48fd-8964-4f99-6495-b2bec7f163e7" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_64525a33-5034-448a-9c19-938ce1958424\">See above (ObservationDefinition/64525a33-5034-448a-9c19-938ce1958424)</a></p><p><b>status</b>: final</p><p><b>code</b>: SE-UHPLC Main Peak (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCHMW "SE-UHPLC HMW")</span></p><p><b>subject</b>: <a href=\"#Medication_c6f5fadd-62e6-3a01-93d9-b3b182f67d06\">See above (Medication/c6f5fadd-62e6-3a01-93d9-b3b182f67d06)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: SE-UHPLC HMW - Beginning <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCHMW - Beginning)</span></p><p><b>value</b>: 9.0 %</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: SE-UHPLC HMW - End <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#SE-UHPLCHMW - End)</span></p><p><b>value</b>: 9.5 %</p></blockquote></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/64525a33-5034-448a-9c19-938ce1958424"
},
"status" : "final",
"code" : // ObservationDefinition/SE-UHPLCHMW
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCHMW",
"display" : "SE-UHPLC HMW"
}
],
"text" : "SE-UHPLC Main Peak (%)"
},
"subject" : {
"reference" : "Medication/c6f5fadd-62e6-3a01-93d9-b3b182f67d06"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-actual-batch-3
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"component" : [
// Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCHMW - Beginning",
"display" : "SE-UHPLC HMW - Beginning"
}
]
},
"valueQuantity" : {
"value" : 9.0,
"unit" : "%"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "SE-UHPLCHMW - End",
"display" : "SE-UHPLC HMW - End"
}
]
},
"valueQuantity" : {
"value" : 9.5,
"unit" : "%"
}
}
]
}
},
{
"fullUrl" : "urn:uuid:55aa47fd-9964-5f97-6495-b2bec7f161e8",
"resource" : {
"resourceType" : "Observation",
"id" : "55aa47fd-9964-5f97-6495-b2bec7f161e8",
"text" : // fillWeight1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"55aa47fd-9964-5f97-6495-b2bec7f161e8\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "55aa47fd-9964-5f97-6495-b2bec7f161e8" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_64515b3c-5134-448a-9c19-939ce2958524\">See above (ObservationDefinition/64515b3c-5134-448a-9c19-939ce2958524)</a></p><p><b>status</b>: final</p><p><b>code</b>: Fill Weight <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Fill Weight)</span></p><p><b>subject</b>: <a href=\"#Medication_339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51\">See above (Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: Fill Weight - Minimum <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Fill Weight - Minimum)</span></p><p><b>value</b>: 9.90 g</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Fill Weight - Maximum <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Fill Weight - Maximum)</span></p><p><b>value</b>: 9.92 g</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Fill Weight - Mean <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Fill Weight - Mean)</span></p><p><b>value</b>: 9.91 CFU/100 mL</p></blockquote></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/64515b3c-5134-448a-9c19-939ce2958524"
},
"status" : "final",
"code" : // ObservationDefinition/FillWeight
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Fill Weight",
"display" : "Fill Weight"
}
]
},
"subject" : {
"reference" : "Medication/339b69fd-4ab1-a1e9-9ea5-1972ba2f6b51"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Medication/medication-batch-information-drug-pq-ex1
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"component" : [
// Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Fill Weight - Minimum",
"display" : "Fill Weight - Minimum"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 9.90,
"unit" : "g"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Fill Weight - Maximum",
"display" : "Fill Weight - Maximum"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 9.92,
"unit" : "g"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Fill Weight - Mean",
"display" : "Fill Weight - Mean"
}
]
},
"valueQuantity" : // todo UCUM
{
"value" : 9.91,
"unit" : "CFU/100 mL"
}
}
]
}
},
{
"fullUrl" : "urn:uuid:45aa47fd-8964-4f96-6495-b2bec7f160f7",
"resource" : {
"resourceType" : "Observation",
"id" : "45aa47fd-8964-4f96-6495-b2bec7f160f7",
"text" : // fillingHomogeneityConclusion-nosubject
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <table>\n <tr>\n <th>Quality Attribute</th>\n <th>Justification</th>\n <th>Analytical Method</th>\n </tr>\n <tr>\n <td>Quantity</td>\n <td>Demonstrates that the drug product content is maintained throughout the filling process</td>\n <td>Protein concentration</td>\n </tr>\n <tr>\n <td>Purity</td>\n <td>Demonstrates the product quality is not adversely impacted over the duration of the fill through aggregation and / or oxidation</td>\n <td>SE-UHPLC</td>\n </tr>\n <tr>\n <td>Subvisible Particles</td>\n <td>Quantitatively determines that subvisible particle content is maintained within specification throughout the filling process</td>\n <td>Light obscuration</td>\n </tr>\n </table>\n </div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/22525a3c-5035-448a-9c19-938ce1958424"
},
"status" : "final",
"code" : // ObservationDefinition/conclusionHomogeneity
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "CONC",
"display" : "Conclusion"
}
],
"text" : "Conclusion"
},
"subject" : // no subject because it applies to all the samples
// added only to keep IG happy
{
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/data-absent-reason",
"valueCode" : "unsupported"
}
],
"display" : "Product"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
]
}
},
// Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"fullUrl" : "urn:uuid:a0694a7a-aafa-4cbe-8135-c788a9a4d3d5",
"resource" : // Section 1.1 - DP Identification
{
"resourceType" : "MedicinalProductDefinition",
"id" : "a0694a7a-aafa-4cbe-8135-c788a9a4d3d5",
"text" : // medicinalproductdefinition-drug-product-pq-ex1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: MedicinalProductDefinition</b><a name=\"a0694a7a-aafa-4cbe-8135-c788a9a4d3d5\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource MedicinalProductDefinition "a0694a7a-aafa-4cbe-8135-c788a9a4d3d5" </p></div><p><b>description</b>: Textual description of the product</p><p><b>combinedPharmaceuticalDoseForm</b>: Gastro-resistant tablet <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (standardterms.edqm.eu#10225000)</span></p><p><b>route</b>: Oral use <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (standardterms.edqm.eu#20053000)</span></p><blockquote><p><b>name</b></p><p><b>productName</b>: Biocure</p><p><b>type</b>: Proprietary <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-productNameType-local-pq.html\">CodeSystem - Product Name Type</a>#Proprietary)</span></p><h3>Parts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Part</b></td><td><b>Type</b></td></tr><tr><td style=\"display: none\">*</td><td>20mg</td><td>Strength part <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-medicinal-product-name-part-type.html\">Product Name Part Type</a>#StrengthPart)</span></td></tr></table></blockquote></div>"
},
"description" : "Textual description of the product",
"combinedPharmaceuticalDoseForm" : {
"coding" : [
{
"system" : "http://standardterms.edqm.eu",
"code" : "10225000",
"display" : "Gastro-resistant tablet"
}
]
},
"route" : [
{
"coding" : [
{
"system" : "http://standardterms.edqm.eu",
"code" : "20053000",
"display" : "Oral use"
}
]
}
],
"name" : [
{
"productName" : "Biocure",
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-productNameType-local-pq",
"code" : "Proprietary",
"display" : "Proprietary"
}
]
},
"part" : [
{
"part" : "20mg",
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/medicinal-product-name-part-type",
"code" : "StrengthPart",
"display" : "Strength part"
}
]
}
}
]
}
]
}
},
{
"fullUrl" : "urn:uuid:a0694a7a-aafa-4cbe-8135-c788a9a4d3d6",
"resource" : {
"resourceType" : "Ingredient",
"id" : "a0694a7a-aafa-4cbe-8135-c788a9a4d3d6",
"text" : // productIngredient
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Ingredient</b><a name=\"a0694a7a-aafa-4cbe-8135-c788a9a4d3d6\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Ingredient "a0694a7a-aafa-4cbe-8135-c788a9a4d3d6" </p></div><p><b>status</b>: active</p><p><b>for</b>: <a href=\"#MedicinalProductDefinition_a0694a7a-aafa-4cbe-8135-c788a9a4d3d5\">See above (MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5)</a></p><p><b>role</b>: Active <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-ingredient-role.html\">Ingredient Role</a>#100000072072)</span></p><blockquote><p><b>substance</b></p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#SubstanceDefinition_57a9af63-315d-1585-a261-0e337b289390\">See above (SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390)</a></td></tr></table></blockquote></div>"
},
"status" : "active",
"for" : [
{
"reference" : "MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5"
}
],
"role" : // MedicinalProductDefinition/medicinalproductdefinition-drug-product-pq-ex1
{
"coding" : [
{
"system" : "http://hl7.org/fhir/ingredient-role",
"code" : "100000072072",
"display" : "Active"
}
]
},
"substance" : {
"code" : {
"reference" : {
"reference" : "SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390"
}
}
}
}
},
// SubstanceDefinition/substancedefinition-component-substance-dxpq-ex1
{
"fullUrl" : "urn:uuid:57a9af63-315d-1585-a261-0e337b289390",
"resource" : {
"resourceType" : "SubstanceDefinition",
"id" : "57a9af63-315d-1585-a261-0e337b289390",
"text" : // substancedefinition-component-substance-dxpq-ex1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"57a9af63-315d-1585-a261-0e337b289390\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition "57a9af63-315d-1585-a261-0e337b289390" </p></div><p><b>manufacturer</b>: <a href=\"#Organization_49d2f0c0-4b28-9271-8aaf-2996a8b9739c\">See above (Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c)</a></p><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>Biocurolol</td></tr></table></div>"
},
"manufacturer" : [
// <meta>
<profile value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/SubstanceDefinition-component-substance-pq"/>
</meta>
{
"reference" : "Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"
}
],
"name" : [
// Organization/organization-dxpq-ex1
{
"name" : "Biocurolol"
}
]
}
},
{
"fullUrl" : "urn:uuid:49d2f0c0-4b28-9271-8aaf-2996a8b9739c",
"resource" : {
"resourceType" : "Organization",
"id" : "49d2f0c0-4b28-9271-8aaf-2996a8b9739c",
"text" : // id value="substance-manufacturer"/
// organization-dxpq-ex1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Organization</b><a name=\"49d2f0c0-4b28-9271-8aaf-2996a8b9739c\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Organization "49d2f0c0-4b28-9271-8aaf-2996a8b9739c" </p></div><p><b>identifier</b>: id:\u00a03003040516</p><p><b>name</b>: AAA Molybdenum Products, Inc.</p><h3>Contacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Address</b></td></tr><tr><td style=\"display: none\">*</td><td>7233 W 116th Pl Ste C Broomfield Colorado 80020 USA </td></tr></table></div>"
},
"identifier" : [
// <meta>
<profile value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Organization-pq"/>
</meta>
{
"system" : "urn:oid:2.16.840.1.113883.4.82",
"value" : "3003040516"
}
],
"name" : "AAA Molybdenum Products, Inc.",
"contact" : [
// FDA establishment identifier
{
"address" : {
"line" : [
"7233 W 116th Pl",
"Ste C"
],
"city" : "Broomfield",
"state" : "Colorado",
"postalCode" : "80020",
"country" : "USA"
}
}
]
}
},
{
"fullUrl" : "urn:uuid:bf6b038b-1334-3dd4-a552-65c169e2265a",
"resource" : // another outer action can be the whole thing, if needed
// removed the main actions for brevity (see manufacturing example)
{
"resourceType" : "PlanDefinition",
"id" : "bf6b038b-1334-3dd4-a552-65c169e2265a",
"meta" : // manufacturingProcess-subset-unlinked
// indicate this is as subset of the resource. In practice it would have it all
{
"profile" : [
🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/PlanDefinition-drug-pq"
],
"tag" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/v3-ObservationValue",
"code" : "SUBSETTED"
}
]
},
"text" : {
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: PlanDefinition</b><a name=\"bf6b038b-1334-3dd4-a552-65c169e2265a\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource PlanDefinition "bf6b038b-1334-3dd4-a552-65c169e2265a" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-PlanDefinition-drug-pq.html\">PlanDefinition - Drug PQ</a></p><p style=\"margin-bottom: 0px\">Tag: <span title=\"{http://terminology.hl7.org/CodeSystem/v3-ObservationValue http://terminology.hl7.org/CodeSystem/v3-ObservationValue}\">http://terminology.hl7.org/CodeSystem/v3-ObservationValue</span></p></div><p><b>Extension - History of Process PQ</b>: This can be text about the history</p><p><b>url</b>: <code>http://example-server.com/fhir/PlanDefinition/bf6b038b-1334-3dd4-a552-65c169e2265a</code></p><p><b>title</b>: Process 1.0</p><p><b>type</b>: Workflow Definition <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.0.0/CodeSystem-plan-definition-type.html\">PlanDefinitionType</a>#workflow-definition; <a href=\"CodeSystem-cs-planType-local-pq.html\">CodeSystem - Plan Type</a>#manufacturing-process "Manufacturing Process")</span></p><p><b>status</b>: active</p><p><b>subject</b>: <a href=\"#MedicinalProductDefinition_a0694a7a-aafa-4cbe-8135-c788a9a4d3d5\">See above (MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5)</a></p><p><b>description</b>: Narrative description of manufacturing process (5)</p><blockquote><p><b>goal</b></p><blockquote><p><b>id</b></p>goal-control-pH</blockquote><p><b>category</b>: Physical Property <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-testCategory-local-pq.html\">CodeSystem - Test Category</a>#C123456)</span></p><p><b>description</b>: Controls - pH <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>priority</b>: Critical <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-goalPriority-local-pq.html\">CodeSystem - Goal Priority</a>#critical)</span></p><h3>Targets</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Measure</b></td><td><b>Detail[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>pH must be in range 6.9 to 7.1 <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#pH "pH")</span></td><td>6.9-7.1 pH</td></tr></table></blockquote><blockquote><p><b>goal</b></p><blockquote><p><b>id</b></p>goal-control-water-content</blockquote><p><b>category</b>: Physical Property <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-testCategory-local-pq.html\">CodeSystem - Test Category</a>#C123456)</span></p><p><b>description</b>: Controls - Water Content <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>priority</b>: Critical <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-goalPriority-local-pq.html\">CodeSystem - Goal Priority</a>#critical)</span></p><h3>Targets</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Measure</b></td><td><b>Detail[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Under 2% <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#WaterContent "Water content")</span></td><td>?-2</td></tr></table></blockquote><blockquote><p><b>goal</b></p><blockquote><p><b>id</b></p>goal-control-particle-size</blockquote><p><b>category</b>: Physical Property <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-testCategory-local-pq.html\">CodeSystem - Test Category</a>#C123456)</span></p><p><b>description</b>: Controls - Particle Size <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>priority</b>: Critical <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-goalPriority-local-pq.html\">CodeSystem - Goal Priority</a>#critical)</span></p><h3>Targets</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Measure</b></td><td><b>Detail[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Under 200 microns <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#particle-size "Particle Size")</span></td><td>?-200</td></tr></table></blockquote><blockquote><p><b>actor</b></p><h3>Options</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>TypeReference</b></td><td><b>Role</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#DeviceDefinition_82a39a18-91cf-a29d-76c1-a9e8bad9494d\">See above (DeviceDefinition/82a39a18-91cf-a29d-76c1-a9e8bad9494d)</a></td><td>Mixing Vessel <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-equipmentClass-local-pq.html\">CodeSystem - Equipment Class</a>#mixing-vessel)</span></td></tr></table></blockquote><blockquote><p><b>actor</b></p><h3>Options</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>TypeReference</b></td><td><b>Role</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#DeviceDefinition_82a39a18-91cf-b29d-76c1-a9e8bad9494d\">See above (DeviceDefinition/82a39a18-91cf-b29d-76c1-a9e8bad9494d)</a></td><td>Receiving Vessel <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-equipmentClass-local-pq.html\">CodeSystem - Equipment Class</a>#receiving-vessel)</span></td></tr></table></blockquote></div>"
},
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-history-of-process-pq",
"valueMarkdown" : "This can be text about the history"
}
],
"url" : "http://example-server.com/fhir/PlanDefinition/bf6b038b-1334-3dd4-a552-65c169e2265a",
"title" : "Process 1.0",
"type" : // http://example-server.com/fhir/PlanDefinition/bf6b038b-1334-3dd4-a552-65c169e2265a
{
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/plan-definition-type",
"code" : "workflow-definition",
"display" : "Workflow Definition"
},
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-planType-local-pq",
"code" : "manufacturing-process",
"display" : "Manufacturing Process"
}
]
},
"status" : "active",
"subjectReference" : {
"reference" : "MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5"
},
"description" : "Narrative description of manufacturing process (5)",
"goal" : [
// MedicinalProductDefinition/medicinalproductdefinition-drug-product-pq-ex1
{
"id" : "goal-control-pH",
"category" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-testCategory-local-pq",
"code" : "C123456",
"display" : "Physical Property"
}
]
},
"description" : // this is mandatory, even though we don't really want it
{
"text" : "Controls - pH"
},
"priority" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-goalPriority-local-pq",
"code" : "critical",
"display" : "Critical"
}
]
},
"target" : [
{
"measure" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "pH",
"display" : "pH"
}
],
"text" : "pH must be in range 6.9 to 7.1"
},
"detailRange" : // detailString value="can also be a string"
{
"low" : {
"value" : 6.9,
"unit" : "pH"
},
"high" : {
"value" : 7.1,
"unit" : "pH"
}
}
}
]
},
{
"id" : "goal-control-water-content",
"category" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-testCategory-local-pq",
"code" : "C123456",
"display" : "Physical Property"
}
]
},
"description" : // this is mandatory, even though we don't really want it
{
"text" : "Controls - Water Content"
},
"priority" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-goalPriority-local-pq",
"code" : "critical",
"display" : "Critical"
}
]
},
"target" : [
{
"measure" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "WaterContent",
"display" : "Water content"
}
],
"text" : "Under 2%"
},
"detailRange" : // detailString value="can also be a string"
{
"high" : {
"value" : 2,
"unit" : "%"
}
}
}
]
},
{
"id" : "goal-control-particle-size",
"category" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-testCategory-local-pq",
"code" : "C123456",
"display" : "Physical Property"
}
]
},
"description" : {
"text" : "Controls - Particle Size"
},
"priority" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-goalPriority-local-pq",
"code" : "critical",
"display" : "Critical"
}
]
},
"target" : [
{
"measure" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "particle-size",
"display" : "Particle Size"
}
],
"text" : "Under 200 microns"
},
"detailRange" : // detailString value="can also be a string"
{
"high" : {
"value" : 200,
"unit" : "microns"
}
}
}
]
}
],
"actor" : [
{
"option" : [
{
"typeReference" : {
"reference" : "DeviceDefinition/82a39a18-91cf-a29d-76c1-a9e8bad9494d"
},
"role" : // DeviceDefinition/mixing-vessel
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-equipmentClass-local-pq",
"code" : "mixing-vessel",
"display" : "Mixing Vessel"
}
]
}
}
]
},
{
"option" : [
{
"typeReference" : {
"reference" : "DeviceDefinition/82a39a18-91cf-b29d-76c1-a9e8bad9494d"
},
"role" : // DeviceDefinition/receiving-tank
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-equipmentClass-local-pq",
"code" : "receiving-vessel",
"display" : "Receiving Vessel"
}
]
}
}
]
}
]
}
},
{
"fullUrl" : "urn:uuid:82a39a18-91cf-a29d-76c1-a9e8bad9494d",
"resource" : {
"resourceType" : "DeviceDefinition",
"id" : "82a39a18-91cf-a29d-76c1-a9e8bad9494d",
"text" : // mixing-vessel
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: DeviceDefinition</b><a name=\"82a39a18-91cf-a29d-76c1-a9e8bad9494d\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource DeviceDefinition "82a39a18-91cf-a29d-76c1-a9e8bad9494d" </p></div><h3>DeviceNames</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td><td><b>Type</b></td></tr><tr><td style=\"display: none\">*</td><td>Mixing Vessel</td><td>registered-name</td></tr></table><h3>Classifications</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td></tr><tr><td style=\"display: none\">*</td><td>Mixing Vessel <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-deviceType-local-pq.html\">CodeSystem - Device Type</a>#mixing-vessel)</span></td></tr></table><h3>Properties</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Capacity <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-deviceProperty-local-pq.html\">CodeSystem - Device Property</a>#Capacity)</span></td><td>1000 litres</td></tr></table></div>"
},
"deviceName" : [
{
"name" : "Mixing Vessel",
"type" : "registered-name"
}
],
"classification" : [
{
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-deviceType-local-pq",
"code" : "mixing-vessel",
"display" : "Mixing Vessel"
}
]
}
}
],
"property" : [
{
"type" : {
"coding" : [
// seems a little different to "maximum capacity
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-deviceProperty-local-pq",
"code" : "Capacity",
"display" : "Capacity"
}
]
},
"valueQuantity" : {
"value" : 1000,
"unit" : "litres"
}
}
]
}
},
{
"fullUrl" : "urn:uuid:82a39a18-91cf-b29d-76c1-a9e8bad9494d",
"resource" : {
"resourceType" : "DeviceDefinition",
"id" : "82a39a18-91cf-b29d-76c1-a9e8bad9494d",
"text" : // receiving-tank
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: DeviceDefinition</b><a name=\"82a39a18-91cf-b29d-76c1-a9e8bad9494d\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource DeviceDefinition "82a39a18-91cf-b29d-76c1-a9e8bad9494d" </p></div><h3>DeviceNames</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td><td><b>Type</b></td></tr><tr><td style=\"display: none\">*</td><td>Receiving Tank</td><td>registered-name</td></tr></table><h3>Classifications</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td></tr><tr><td style=\"display: none\">*</td><td>Receiving Tank <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-deviceType-local-pq.html\">CodeSystem - Device Type</a>#receiving-tank)</span></td></tr></table><h3>Properties</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Capacity <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-deviceProperty-local-pq.html\">CodeSystem - Device Property</a>#Capacity)</span></td><td>1200 litres</td></tr></table></div>"
},
"deviceName" : [
{
"name" : "Receiving Tank",
"type" : "registered-name"
}
],
"classification" : [
{
"type" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-deviceType-local-pq",
"code" : "receiving-tank",
"display" : "Receiving Tank"
}
]
}
}
],
"property" : [
{
"type" : {
"coding" : [
// seems a little different to "maximum capacity
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-deviceProperty-local-pq",
"code" : "Capacity",
"display" : "Capacity"
}
]
},
"valueQuantity" : {
"value" : 1200,
"unit" : "litres"
}
}
]
}
},
{
"fullUrl" : "urn:uuid:fc078762-81c5-5656-9744-13c7ad1e595b",
"resource" : {
"resourceType" : "Substance",
"id" : "fc078762-81c5-5656-9744-13c7ad1e595b",
"text" : // <id value="actual-batch-substance"/>
// substance-dxpq-ex1
{
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Substance</b><a name=\"fc078762-81c5-5656-9744-13c7ad1e595b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance "fc078762-81c5-5656-9744-13c7ad1e595b" </p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-07</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 5 kg</p><blockquote><p><b>url</b></p><code>batchUtilization</code></blockquote><p><b>value</b>: Development <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.0.0/CodeSystem-v3-nciThesaurus.html\">NCI Thesaurus</a>#C133991)</span></p><blockquote><p><b>url</b></p><code>assignedManufacturer</code></blockquote><p><b>value</b>: <a href=\"#Organization_49d2f0c0-4b28-9271-8aaf-2996a8b9739c\">See above (Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c)</a></p></blockquote><p><b>Extension - Batch Release Date PQ</b>: 2019-09-08</p><p><b>Extension - Batch Retest Date PQ</b>: 2022-09-08</p><p><b>Extension - Actual Yield PQ</b>: 4.8 kg</p><p><b>identifier</b>: id:\u00a0CAT1</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#SubstanceDefinition_57a9af63-315d-1585-a261-0e337b289390\">See above (SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390)</a></td></tr></table></div>"
},
"extension" : [
// <meta>
<profile value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-pq"/>
</meta>
{
"url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
"extension" : [
{
"url" : "manufacturingDate",
"valueDateTime" : "2019-09-07"
},
{
"url" : "batchQuantity",
"valueQuantity" : {
"value" : 5,
"unit" : "kg"
}
},
{
"url" : "batchUtilization",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
"code" : "C133991",
"display" : "Development"
}
]
}
},
{
"url" : "assignedManufacturer",
"valueReference" : {
"reference" : "Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"
}
}
]
},
// Organization/organization-dxpq-ex1
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq",
"valueDateTime" : "2019-09-08"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-retest-date-pq",
"valueDateTime" : "2022-09-08"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq",
"valueQuantity" : {
"value" : 4.8,
"unit" : "kg"
}
}
],
"identifier" : [
// local extensions
{
"value" : "CAT1"
}
],
"instance" : true,
"code" : {
"reference" : {
"reference" : "SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390"
}
}
}
},
// SubstanceDefinition/substancedefinition-component-substance-dxpq-ex1
{
"fullUrl" : "urn:uuid:cb31d747-2338-88d5-342c-8e9c097e4dad",
"resource" : {
"resourceType" : "Substance",
"id" : "cb31d747-2338-88d5-342c-8e9c097e4dad",
"text" : // actual-batch-substance-2
{
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Substance</b><a name=\"cb31d747-2338-88d5-342c-8e9c097e4dad\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance "cb31d747-2338-88d5-342c-8e9c097e4dad" </p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-07</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 5 kg</p><blockquote><p><b>url</b></p><code>batchUtilization</code></blockquote><p><b>value</b>: Development <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.0.0/CodeSystem-v3-nciThesaurus.html\">NCI Thesaurus</a>#C133991)</span></p><blockquote><p><b>url</b></p><code>assignedManufacturer</code></blockquote><p><b>value</b>: <a href=\"#Organization_49d2f0c0-4b28-9271-8aaf-2996a8b9739c\">See above (Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c)</a></p></blockquote><p><b>Extension - Batch Release Date PQ</b>: 2019-09-08</p><p><b>Extension - Batch Retest Date PQ</b>: 2022-09-08</p><p><b>Extension - Actual Yield PQ</b>: 4.8 kg</p><p><b>identifier</b>: id:\u00a0SUB2</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#SubstanceDefinition_57a9af63-315d-1585-a261-0e337b289390\">See above (SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390)</a></td></tr></table></div>"
},
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
"extension" : [
{
"url" : "manufacturingDate",
"valueDateTime" : "2019-09-07"
},
{
"url" : "batchQuantity",
"valueQuantity" : {
"value" : 5,
"unit" : "kg"
}
},
{
"url" : "batchUtilization",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
"code" : "C133991",
"display" : "Development"
}
]
}
},
{
"url" : "assignedManufacturer",
"valueReference" : {
"reference" : "Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"
}
}
]
},
// Organization/organization-dxpq-ex1
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq",
"valueDateTime" : "2019-09-08"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-retest-date-pq",
"valueDateTime" : "2022-09-08"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq",
"valueQuantity" : {
"value" : 4.8,
"unit" : "kg"
}
}
],
"identifier" : [
// local extensions
{
"value" : "SUB2"
}
],
"instance" : true,
"code" : {
"reference" : {
"reference" : "SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390"
}
}
}
},
// SubstanceDefinition/substancedefinition-component-substance-dxpq-ex1
{
"fullUrl" : "urn:uuid:1551f97b-6f6d-825e-1fb3-44b0b090808c",
"resource" : {
"resourceType" : "Substance",
"id" : "1551f97b-6f6d-825e-1fb3-44b0b090808c",
"text" : // actual-batch-substance-3
{
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Substance</b><a name=\"1551f97b-6f6d-825e-1fb3-44b0b090808c\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance "1551f97b-6f6d-825e-1fb3-44b0b090808c" </p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-07</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 5 kg</p><blockquote><p><b>url</b></p><code>batchUtilization</code></blockquote><p><b>value</b>: Development <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.0.0/CodeSystem-v3-nciThesaurus.html\">NCI Thesaurus</a>#C133991)</span></p><blockquote><p><b>url</b></p><code>assignedManufacturer</code></blockquote><p><b>value</b>: <a href=\"#Organization_49d2f0c0-4b28-9271-8aaf-2996a8b9739c\">See above (Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c)</a></p></blockquote><p><b>Extension - Batch Release Date PQ</b>: 2019-09-08</p><p><b>Extension - Batch Retest Date PQ</b>: 2022-09-08</p><p><b>Extension - Actual Yield PQ</b>: 4.8 kg</p><p><b>identifier</b>: id:\u00a0SUB3</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#SubstanceDefinition_57a9af63-315d-1585-a261-0e337b289390\">See above (SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390)</a></td></tr></table></div>"
},
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
"extension" : [
{
"url" : "manufacturingDate",
"valueDateTime" : "2019-09-07"
},
{
"url" : "batchQuantity",
"valueQuantity" : {
"value" : 5,
"unit" : "kg"
}
},
{
"url" : "batchUtilization",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
"code" : "C133991",
"display" : "Development"
}
]
}
},
{
"url" : "assignedManufacturer",
"valueReference" : {
"reference" : "Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"
}
}
]
},
// Organization/organization-dxpq-ex1
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq",
"valueDateTime" : "2019-09-08"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-retest-date-pq",
"valueDateTime" : "2022-09-08"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq",
"valueQuantity" : {
"value" : 4.8,
"unit" : "kg"
}
}
],
"identifier" : [
// local extensions
{
"value" : "SUB3"
}
],
"instance" : true,
"code" : {
"reference" : {
"reference" : "SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390"
}
}
}
}
]
}
IG © HL7 International / Biomedical Research and Regulation. Package hl7.fhir.uv.pharm-quality#1.0.0-ballot based on FHIR 5.0.0. Generated 2023-12-18
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