Pharmaceutical Quality (Industry)
1.0.0-ballot - ballot
Pharmaceutical Quality (Industry)
1.0.0-ballot - ballot
This page is part of the Pharmaceutical Quality (Industry) (v1.0.0-ballot: STU1 Ballot 1) based on FHIR (HL7® FHIR® Standard) v5.0.0. . For a full list of available versions, see the Directory of published versions
<Bundle xmlns="http://hl7.org/fhir">
<!-- Substance Process Validation -->
<id value="bundle-product-process-validation-pq-ex2-sub"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Bundle-product-process-validation-pq"/>
</meta>
<type value="collection"/>
<entry>
<fullUrl value="urn:uuid:2038e4c7-22b8-4c56-2d28-6c077648763f"/>
<resource>
<PlanDefinition>
<!-- validationProtocol -->
<id value="2038e4c7-22b8-4c56-2d28-6c077648763f"/>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: PlanDefinition</b><a name="2038e4c7-22b8-4c56-2d28-6c077648763f"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource PlanDefinition "2038e4c7-22b8-4c56-2d28-6c077648763f" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f</code></p><p><b>title</b>: DP PROCESS VALIDATION</p><p><b>type</b>: Workflow Definition <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.0.0/CodeSystem-plan-definition-type.html">PlanDefinitionType</a>#workflow-definition; <a href="CodeSystem-cs-planType-local-pq.html">CodeSystem - Plan Type</a>#process-validation "Process Validation")</span></p><p><b>status</b>: active</p><p><b>subject</b>: <a href="#SubstanceDefinition_57a9af63-315d-1585-a261-0e337b289390">See above (SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390)</a></p><p><b>description</b>: Pre-defined validation acceptance criteria were established based on manufacturing development data derived from process characterization studies...</p><blockquote><p><b>action</b></p><p><b>Extension - Process Step Scale PQ</b>: Production Scale (Details: http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStepScale-local-pq code PROD = 'Production Scale', stated as 'Production Scale')</p><blockquote><p><b>Extension - Process Parameters PQ</b></p><blockquote><p><b>url</b></p><code>parameter</code></blockquote><p><b>value</b>: Mix speed <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-processParameter-local-pq.html">CodeSystem - Process Parameter</a>#SPEED)</span></p><blockquote><p><b>url</b></p><code>value</code></blockquote><p><b>value</b>: 1500 rpm</p></blockquote><p><b>prefix</b>: 1</p><p><b>title</b>: Step 1 Yield</p><p><b>description</b>: Description of this step</p><p><b>code</b>: Particle Size Reduction <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-manufacturingStep-local-pq.html">CodeSystem - Manufacturing Step</a>#particleSizeReduction)</span></p><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Starting material</span></p><p><b>role</b>: Starting Material <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-manufacturingParticipantRole-local-pq.html">CodeSystem - Manufacturing Participant Role</a>#StartingMaterial)</span></p></blockquote><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Intermediate material</span></p><p><b>role</b>: Intermediate Material <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-manufacturingParticipantRole-local-pq.html">CodeSystem - Manufacturing Participant Role</a>#IntermediateMaterial)</span></p></blockquote><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Resulting material</span></p><p><b>role</b>: Resulting Material <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-manufacturingParticipantRole-local-pq.html">CodeSystem - Manufacturing Participant Role</a>#ResultingMaterial)</span></p></blockquote><h3>Actions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><code>ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72</code></td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: Step 1 In-Process Control Data</p><p><b>code</b>: Step 1 In-Process Control Data <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-manufacturingStep-local-pq.html">CodeSystem - Manufacturing Step</a>#Step1In-ProcessControlData)</span></p><h3>Actions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><code>ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72</code></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><code>ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72</code></td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: Step 1 DS Release Testing Results</p><p><b>code</b>: Step 1 DS Release Testing Results <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-manufacturingStep-local-pq.html">CodeSystem - Manufacturing Step</a>#Step1DSReleaseTestingResults)</span></p><h3>Actions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><code>ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72</code></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><code>ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d</code></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><code>ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e</code></td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>Extension - Process Step Scale PQ</b>: Production Scale (Details: http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStepScale-local-pq code PROD = 'Production Scale', stated as 'Production Scale')</p><p><b>prefix</b>: 2</p><p><b>title</b>: Step 2 Yield</p><p><b>description</b>: Description of this step</p><p><b>code</b>: Drying <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-manufacturingStep-local-pq.html">CodeSystem - Manufacturing Step</a>#drying)</span></p><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Starting material</span></p><p><b>role</b>: Starting Material <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-manufacturingParticipantRole-local-pq.html">CodeSystem - Manufacturing Participant Role</a>#StartingMaterial)</span></p></blockquote><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Intermediate material</span></p><p><b>role</b>: Intermediate Material <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-manufacturingParticipantRole-local-pq.html">CodeSystem - Manufacturing Participant Role</a>#IntermediateMaterial)</span></p></blockquote><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Resulting material</span></p><p><b>role</b>: Resulting Material <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-manufacturingParticipantRole-local-pq.html">CodeSystem - Manufacturing Participant Role</a>#ResultingMaterial)</span></p></blockquote><h3>Actions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><code>ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72</code></td></tr></table></blockquote></div>
</text>
<!-- http://example-server.com/fhir/PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f -->
<url
value="http://example-server.com/fhir/PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f"/>
<title value="DP PROCESS VALIDATION"/>
<type>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/plan-definition-type"/>
<code value="workflow-definition"/>
<display value="Workflow Definition"/>
</coding>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-planType-local-pq"/>
<code value="process-validation"/>
<display value="Process Validation"/>
</coding>
</type>
<status value="active"/>
<subjectReference>
<!-- SubstanceDefinition/substancedefinition-component-substance-dxpq-ex1 -->
<reference
value="SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390"/>
</subjectReference>
<description
value="Pre-defined validation acceptance criteria were established based on manufacturing development data derived from process characterization studies..."/>
<action>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-process-step-scale-pq">
<valueCoding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStepScale-local-pq"/>
<code value="PROD"/>
<display value="Production Scale"/>
</valueCoding>
</extension>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-process-parameters-pq">
<extension url="parameter">
<valueCodeableConcept>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-processParameter-local-pq"/>
<code value="SPEED"/>
<display value="Mix speed"/>
</coding>
</valueCodeableConcept>
</extension>
<extension url="value">
<valueQuantity>
<value value="1500"/>
<unit value="rpm"/>
</valueQuantity>
</extension>
</extension>
<prefix value="1"/>
<title value="Step 1 Yield"/>
<description value="Description of this step"/>
<!-- text value="Step 2 in the process - free text is possible"/ -->
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStep-local-pq"/>
<code value="particleSizeReduction"/>
<display value="Particle Size Reduction"/>
</coding>
</code>
<participant>
<typeReference>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq">
<valueReference>
<!-- SubstanceDefinition/startingMaterial -->
<reference
value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153"/>
</valueReference>
</extension>
<display value="Starting material"/>
</typeReference>
<role>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingParticipantRole-local-pq"/>
<code value="StartingMaterial"/>
<display value="Starting Material"/>
</coding>
</role>
</participant>
<participant>
<typeReference>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq">
<valueReference>
<!-- SubstanceDefinition/intermediateMaterial -->
<reference
value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155"/>
</valueReference>
</extension>
<display value="Intermediate material"/>
</typeReference>
<role>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingParticipantRole-local-pq"/>
<code value="IntermediateMaterial"/>
<display value="Intermediate Material"/>
</coding>
</role>
</participant>
<participant>
<typeReference>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq">
<valueReference>
<!-- SubstanceDefinition/resultingMaterial -->
<reference
value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821154"/>
</valueReference>
</extension>
<display value="Resulting material"/>
</typeReference>
<role>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingParticipantRole-local-pq"/>
<code value="ResultingMaterial"/>
<display value="Resulting Material"/>
</coding>
</role>
</participant>
<action>
<code>
<text value="Test"/>
</code>
<!-- ObservationDefinition/Step1Yield -->
<definitionCanonical
value="ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"/>
</action>
</action>
<action>
<title value="Step 1 In-Process Control Data"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStep-local-pq"/>
<code value="Step1In-ProcessControlData"/>
<display value="Step 1 In-Process Control Data"/>
</coding>
</code>
<action>
<code>
<text value="Test"/>
</code>
<!-- ObservationDefinition/ResidualWaterContent -->
<definitionCanonical
value="ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"/>
</action>
<action>
<code>
<text value="Test"/>
</code>
<!-- ObservationDefinition/ResidualStartingMaterial1byHPLC -->
<definitionCanonical
value="ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72"/>
</action>
</action>
<action>
<title value="Step 1 DS Release Testing Results"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStep-local-pq"/>
<code value="Step1DSReleaseTestingResults"/>
<display value="Step 1 DS Release Testing Results"/>
</coding>
</code>
<action>
<code>
<text value="Test"/>
</code>
<!-- ObservationDefinition/AppearanceSubstance -->
<definitionCanonical
value="ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"/>
</action>
<action>
<code>
<text value="Test"/>
</code>
<!-- ObservationDefinition/IdentificationSubstance -->
<definitionCanonical
value="ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d"/>
</action>
<action>
<code>
<text value="Test"/>
</code>
<!-- ObservationDefinition/AssaySubstance -->
<definitionCanonical
value="ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e"/>
</action>
</action>
<action>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-process-step-scale-pq">
<valueCoding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStepScale-local-pq"/>
<code value="PROD"/>
<display value="Production Scale"/>
</valueCoding>
</extension>
<prefix value="2"/>
<title value="Step 2 Yield"/>
<description value="Description of this step"/>
<!-- text value="Step 2 in the process - free text is possible"/ -->
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStep-local-pq"/>
<code value="drying"/>
<display value="Drying"/>
</coding>
</code>
<participant>
<typeReference>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq">
<valueReference>
<!-- SubstanceDefinition/startingMaterialStep2 -->
<reference
value="SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153"/>
</valueReference>
</extension>
<display value="Starting material"/>
</typeReference>
<role>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingParticipantRole-local-pq"/>
<code value="StartingMaterial"/>
<display value="Starting Material"/>
</coding>
</role>
</participant>
<participant>
<typeReference>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq">
<valueReference>
<!-- SubstanceDefinition/intermediateMaterialStep2 -->
<reference
value="SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155"/>
</valueReference>
</extension>
<display value="Intermediate material"/>
</typeReference>
<role>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingParticipantRole-local-pq"/>
<code value="IntermediateMaterial"/>
<display value="Intermediate Material"/>
</coding>
</role>
</participant>
<participant>
<typeReference>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq">
<valueReference>
<!-- SubstanceDefinition/resultingMaterialStep2 -->
<reference
value="SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821154"/>
</valueReference>
</extension>
<display value="Resulting material"/>
</typeReference>
<role>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingParticipantRole-local-pq"/>
<code value="ResultingMaterial"/>
<display value="Resulting Material"/>
</coding>
</role>
</participant>
<action>
<code>
<text value="Test"/>
</code>
<!-- ObservationDefinition/Step2Yield -->
<definitionCanonical
value="ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"/>
</action>
</action>
</PlanDefinition>
</resource>
</entry>
<!-- Diagnostic report doesn't carry much extra value but does collect all the observations -->
<entry>
<fullUrl value="urn:uuid:b664977d-799d-a1ce-928a-5def2a9955bd"/>
<resource>
<DiagnosticReport>
<!-- ideally this wants a subject, but it can only be a Medication (batch) and we have multiple.
however the observations themselves do have subjects -->
<id value="processValidationReport"/>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: DiagnosticReport</b><a name="processValidationReport"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource DiagnosticReport "processValidationReport" </p></div><p><b>Triggered by</b>: <a href="#PlanDefinition_2038e4c7-22b8-4c56-2d28-6c077648763f">See above (PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f)</a></p><p><b>status</b>: final</p><p><b>code</b>: Process Validation Report <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-reportType-local-pq.html">CodeSystem - Report Type</a>#Process Validation Report)</span></p><p><b>effective</b>: 2020-12</p><p><b>result</b>: </p><ul><li><a href="#Observation_9c56948c-2a39-6609-1c01-4d197ea57a33">See above (Observation/9c56948c-2a39-6609-1c01-4d197ea57a33)</a></li><li><a href="#Observation_9c56948a-2b39-6609-1c01-4d197ea57a33">See above (Observation/9c56948a-2b39-6609-1c01-4d197ea57a33)</a></li><li><a href="#Observation_9c56948a-2a39-6609-1c01-4d197ea57a33">See above (Observation/9c56948a-2a39-6609-1c01-4d197ea57a33)</a></li><li><a href="#Observation_9c56958c-2a39-6609-1c01-4d197ea57a33">See above (Observation/9c56958c-2a39-6609-1c01-4d197ea57a33)</a></li><li><a href="#Observation_9c56968a-2b39-6609-1c01-4d197ea57a33">See above (Observation/9c56968a-2b39-6609-1c01-4d197ea57a33)</a></li><li><a href="#Observation_9c56978a-2a39-6609-1c01-4d197ea57a33">See above (Observation/9c56978a-2a39-6609-1c01-4d197ea57a33)</a></li><li><a href="#Observation_9c56948c-2a39-6609-2c01-4d197ea57a33">See above (Observation/9c56948c-2a39-6609-2c01-4d197ea57a33)</a></li><li><a href="#Observation_9c56948c-2a49-6609-2c01-4d197ea57a33">See above (Observation/9c56948c-2a49-6609-2c01-4d197ea57a33)</a></li><li><a href="#Observation_9c56948c-2a39-6609-2c01-4d197eb57a33">See above (Observation/9c56948c-2a39-6609-2c01-4d197eb57a33)</a></li><li><a href="#Observation_9c56958c-2a39-6609-2c01-4d197ea57a33">See above (Observation/9c56958c-2a39-6609-2c01-4d197ea57a33)</a></li><li><a href="#Observation_9c56968c-2a49-6609-2c01-4d197ea57a33">See above (Observation/9c56968c-2a49-6609-2c01-4d197ea57a33)</a></li><li><a href="#Observation_9c56978c-2a39-6609-2c01-4d197eb57a33">See above (Observation/9c56978c-2a39-6609-2c01-4d197eb57a33)</a></li><li><a href="#Observation_9c56948d-2a39-6609-1c01-4d197ea57a33">See above (Observation/9c56948d-2a39-6609-1c01-4d197ea57a33)</a></li><li><a href="#Observation_9c56948c-2b39-6609-1c01-4d197ea57a33">See above (Observation/9c56948c-2b39-6609-1c01-4d197ea57a33)</a></li><li><a href="#Observation_9c56948b-2a39-6609-1c01-4d197ea57a33">See above (Observation/9c56948b-2a39-6609-1c01-4d197ea57a33)</a></li></ul><p><b>conclusion</b>: The samples have been assessed and the conclusion is...</p></div>
</text>
<extension
url="http://hl7.org/fhir/StructureDefinition/workflow-triggeredBy">
<valueReference>
<!-- PlanDefinition/validationProtocol -->
<reference
value="PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f"/>
</valueReference>
</extension>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-reportType-local-pq"/>
<code value="Process Validation Report"/>
<display value="Process Validation Report"/>
</coding>
</code>
<effectiveDateTime value="2020-12"/>
<result>
<!-- Observation/step1Yield1 -->
<reference
value="Observation/9c56948c-2a39-6609-1c01-4d197ea57a33"/>
</result>
<result>
<!-- Observation/step1Yield2 -->
<reference
value="Observation/9c56948a-2b39-6609-1c01-4d197ea57a33"/>
</result>
<result>
<!-- Observation/step1Yield3 -->
<reference
value="Observation/9c56948a-2a39-6609-1c01-4d197ea57a33"/>
</result>
<result>
<!-- Observation/residualWaterContent1 -->
<reference
value="Observation/9c56958c-2a39-6609-1c01-4d197ea57a33"/>
</result>
<result>
<!-- Observation/residualWaterContent2 -->
<reference
value="Observation/9c56968a-2b39-6609-1c01-4d197ea57a33"/>
</result>
<result>
<!-- Observation/residualWaterContent3 -->
<reference
value="Observation/9c56978a-2a39-6609-1c01-4d197ea57a33"/>
</result>
<result>
<!-- Observation/appearanceSubstance1 -->
<reference
value="Observation/9c56948c-2a39-6609-2c01-4d197ea57a33"/>
</result>
<result>
<!-- Observation/appearanceSubstance2 -->
<reference
value="Observation/9c56948c-2a49-6609-2c01-4d197ea57a33"/>
</result>
<result>
<!-- Observation/appearanceSubstance3 -->
<reference
value="Observation/9c56948c-2a39-6609-2c01-4d197eb57a33"/>
</result>
<result>
<!-- Observation/identificationSubstance1 -->
<reference
value="Observation/9c56958c-2a39-6609-2c01-4d197ea57a33"/>
</result>
<result>
<!-- Observation/identificationSubstance2 -->
<reference
value="Observation/9c56968c-2a49-6609-2c01-4d197ea57a33"/>
</result>
<result>
<!-- Observation/identificationSubstance3 -->
<reference
value="Observation/9c56978c-2a39-6609-2c01-4d197eb57a33"/>
</result>
<result>
<!-- Observation/step2Yield1 -->
<reference
value="Observation/9c56948d-2a39-6609-1c01-4d197ea57a33"/>
</result>
<result>
<!-- Observation/step2Yield2 -->
<reference
value="Observation/9c56948c-2b39-6609-1c01-4d197ea57a33"/>
</result>
<result>
<!-- Observation/step2Yield3 -->
<reference
value="Observation/9c56948b-2a39-6609-1c01-4d197ea57a33"/>
</result>
<conclusion
value="The samples have been assessed and the conclusion is..."/>
</DiagnosticReport>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"/>
<resource>
<ObservationDefinition>
<!-- AppearanceSubstance -->
<id value="fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: ObservationDefinition</b><a name="fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition "fc07b5d5-9fe1-92c2-2d06-57cb5b295e72" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72</code></p><p><b>title</b>: Appearance</p><p><b>status</b>: active</p><p><b>code</b>: Appearance <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq.html">CodeSystem - Example Local Codes - Drug</a>#Appearance)</span></p><p><b>method</b>: Visual inspection <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><h3>QualifiedValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Extension</b></td></tr><tr><td style="display: none">*</td><td/></tr></table></div>
</text>
<!-- http://example-server.com/fhir/ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72 -->
<url
value="http://example-server.com/fhir/ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"/>
<title value="Appearance"/>
<status value="active"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq"/>
<code value="Appearance"/>
<display value="Appearance"/>
</coding>
<text value="Appearance"/>
</code>
<method>
<text value="Visual inspection"/>
</method>
<qualifiedValue>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-text-pq">
<valueString
value="White to off-white, to red, to orange, to brown solid"/>
</extension>
</qualifiedValue>
</ObservationDefinition>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:3b1e878e-4bc9-8864-862f-e28b21233e8d"/>
<resource>
<ObservationDefinition>
<!-- IdentificationSubstance -->
<id value="3b1e878e-4bc9-8864-862f-e28b21233e8d"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: ObservationDefinition</b><a name="3b1e878e-4bc9-8864-862f-e28b21233e8d"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition "3b1e878e-4bc9-8864-862f-e28b21233e8d" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d</code></p><p><b>title</b>: ID by HPLC</p><p><b>status</b>: active</p><p><b>code</b>: ID by HPLC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq.html">CodeSystem - Example Local Codes - Drug</a>#IDT "Identification")</span></p><p><b>method</b>: ID by UHPLC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><h3>QualifiedValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Extension</b></td></tr><tr><td style="display: none">*</td><td/></tr></table></div>
</text>
<!-- http://example-server.com/fhir/ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d -->
<url
value="http://example-server.com/fhir/ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d"/>
<title value="ID by HPLC"/>
<status value="active"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq"/>
<code value="IDT"/>
<display value="Identification"/>
</coding>
<text value="ID by HPLC"/>
</code>
<method>
<text value="ID by UHPLC"/>
</method>
<qualifiedValue>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-text-pq">
<valueString value="Conforms to standard"/>
</extension>
</qualifiedValue>
</ObservationDefinition>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:12e7e672-40a6-4036-3c1f-b8ba6a7d045e"/>
<resource>
<ObservationDefinition>
<!-- AssaySubstance -->
<id value="12e7e672-40a6-4036-3c1f-b8ba6a7d045e"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: ObservationDefinition</b><a name="12e7e672-40a6-4036-3c1f-b8ba6a7d045e"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition "12e7e672-40a6-4036-3c1f-b8ba6a7d045e" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e</code></p><p><b>title</b>: Assay by HPLC (as is) (w/w%)</p><p><b>status</b>: active</p><p><b>code</b>: Assay by HPLC (as is) (w/w%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq.html">CodeSystem - Example Local Codes - Drug</a>#ASSAY "Assay")</span></p><p><b>method</b>: Assay by UHPLC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><h3>QualifiedValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Range</b></td></tr><tr><td style="display: none">*</td><td>95-101 %</td></tr></table></div>
</text>
<!-- http://example-server.com/fhir/ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e -->
<url
value="http://example-server.com/fhir/ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e"/>
<title value="Assay by HPLC (as is) (w/w%)"/>
<status value="active"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq"/>
<code value="ASSAY"/>
<display value="Assay"/>
</coding>
<text value="Assay by HPLC (as is) (w/w%)"/>
</code>
<method>
<text value="Assay by UHPLC"/>
</method>
<qualifiedValue>
<range>
<low>
<value value="95"/>
<unit value="%"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</low>
<high>
<value value="101"/>
<unit value="%"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</high>
</range>
</qualifiedValue>
</ObservationDefinition>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"/>
<resource>
<ObservationDefinition>
<!-- Step1Yield -->
<id value="fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: ObservationDefinition</b><a name="fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition "fd17b5d6-9fe1-91c2-2d06-47cb5b295e72" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72</code></p><p><b>title</b>: Yield (%)</p><p><b>status</b>: active</p><p><b>code</b>: Yield (%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq.html">CodeSystem - Example Local Codes - Drug</a>#Yield (%))</span></p></div>
</text>
<!-- http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72 -->
<url
value="http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"/>
<title value="Yield (%)"/>
<status value="active"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq"/>
<code value="Yield (%)"/>
<display value="Yield (%)"/>
</coding>
<text value="Yield (%)"/>
</code>
</ObservationDefinition>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"/>
<resource>
<ObservationDefinition>
<!-- Step2Yield -->
<id value="fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: ObservationDefinition</b><a name="fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition "fd17b5d7-9fe1-91c2-2d06-47cb5b295e72" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72</code></p><p><b>title</b>: Yield (%)</p><p><b>status</b>: active</p><p><b>code</b>: Yield (%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq.html">CodeSystem - Example Local Codes - Drug</a>#Yield (%))</span></p></div>
</text>
<!-- http://example-server.com/fhir/ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72 -->
<url
value="http://example-server.com/fhir/ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"/>
<title value="Yield (%)"/>
<status value="active"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq"/>
<code value="Yield (%)"/>
<display value="Yield (%)"/>
</coding>
<text value="Yield (%)"/>
</code>
</ObservationDefinition>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"/>
<resource>
<ObservationDefinition>
<!-- ResidualWaterContent -->
<id value="fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: ObservationDefinition</b><a name="fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition "fc27b5d6-9fe1-91c2-2d16-57cb5b295e72" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72</code></p><p><b>title</b>: Residual Water Content (w/w%)</p><p><b>status</b>: active</p><p><b>code</b>: Residual Water Content (w/w%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq.html">CodeSystem - Example Local Codes - Drug</a>#ResidualWaterContent)</span></p><h3>QualifiedValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Extension</b></td><td><b>Range</b></td></tr><tr><td style="display: none">*</td><td/><td>?-7.15</td></tr></table></div>
</text>
<!-- http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72 -->
<url
value="http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"/>
<title value="Residual Water Content (w/w%)"/>
<status value="active"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq"/>
<code value="ResidualWaterContent"/>
<display value="Residual Water Content (w/w%)"/>
</coding>
<text value="Residual Water Content (w/w%)"/>
</code>
<qualifiedValue>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-criticality-pq">
<valueCodeableConcept>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-qualifiedValueCriticality-local-pq"/>
<code value="Non-critical"/>
<display value="Non-critical"/>
</coding>
<text value="Non-critical"/>
</valueCodeableConcept>
</extension>
<range>
<high>
<value value="7.15"/>
<unit value="%"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</high>
</range>
</qualifiedValue>
</ObservationDefinition>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:fc27b5d6-9ff1-91c2-2d16-57cb5b295e72"/>
<resource>
<ObservationDefinition>
<!-- ResidualStartingMaterial1byHPLC -->
<id value="fc27b5d6-9ff1-91c2-2d16-57cb5b295e72"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: ObservationDefinition</b><a name="fc27b5d6-9ff1-91c2-2d16-57cb5b295e72"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition "fc27b5d6-9ff1-91c2-2d16-57cb5b295e72" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72</code></p><p><b>title</b>: Reaction conversion: residual starting material 1 by HPLC (Step Aa) (LC area %)</p><p><b>status</b>: active</p><p><b>code</b>: Reaction conversion: Residual Starting Material 1 by HPLC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq.html">CodeSystem - Example Local Codes - Drug</a>#Reaction conversion: Residual Starting Material 1 by HPLC)</span></p><h3>QualifiedValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Extension</b></td><td><b>Range</b></td></tr><tr><td style="display: none">*</td><td/><td>?-23</td></tr></table></div>
</text>
<!-- http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72 -->
<url
value="http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72"/>
<title
value="Reaction conversion: residual starting material 1 by HPLC (Step Aa) (LC area %)"/>
<status value="active"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq"/>
<code
value="Reaction conversion: Residual Starting Material 1 by HPLC"/>
<display
value="Reaction conversion: Residual Starting Material 1 by HPLC"/>
</coding>
<text
value="Reaction conversion: Residual Starting Material 1 by HPLC"/>
</code>
<qualifiedValue>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-criticality-pq">
<valueCodeableConcept>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-qualifiedValueCriticality-local-pq"/>
<code value="critical"/>
<display value="Critical"/>
</coding>
<text value="Critical"/>
</valueCodeableConcept>
</extension>
<range>
<high>
<value value="23"/>
<unit value="%"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</high>
</range>
</qualifiedValue>
</ObservationDefinition>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:9c56948c-2a39-6609-2c01-4d197ea57a33"/>
<resource>
<Observation>
<!-- appearanceSubstance1 -->
<id value="9c56948c-2a39-6609-2c01-4d197ea57a33"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="9c56948c-2a39-6609-2c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "9c56948c-2a39-6609-2c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href="#ObservationDefinition_fc07b5d5-9fe1-92c2-2d06-57cb5b295e72">See above (ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: Appearance <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq.html">CodeSystem - Example Local Codes - Drug</a>#Appearance)</span></p><p><b>subject</b>: <a href="#Substance_fc178763-81c5-5656-9744-13c7ad1e595b">See above (Substance/fc178763-81c5-5656-9744-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href="#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: Off-white solid</p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/AppearanceSubstance -->
<reference
value="ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq"/>
<code value="Appearance"/>
<display value="Appearance"/>
</coding>
<text value="Appearance"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-itermediate-1 -->
<reference value="Substance/fc178763-81c5-5656-9744-13c7ad1e595b"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueString value="Off-white solid"/>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:9c56948c-2a49-6609-2c01-4d197ea57a33"/>
<resource>
<Observation>
<!-- appearanceSubstance2 -->
<id value="9c56948c-2a49-6609-2c01-4d197ea57a33"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="9c56948c-2a49-6609-2c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "9c56948c-2a49-6609-2c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href="#ObservationDefinition_fc07b5d5-9fe1-92c2-2d06-57cb5b295e72">See above (ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: Appearance <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq.html">CodeSystem - Example Local Codes - Drug</a>#Appearance)</span></p><p><b>subject</b>: <a href="#Substance_fc178764-81d5-5656-9744-13c7ad1e595b">See above (Substance/fc178764-81d5-5656-9744-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href="#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: Off-white solid</p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/AppearanceSubstance -->
<reference
value="ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq"/>
<code value="Appearance"/>
<display value="Appearance"/>
</coding>
<text value="Appearance"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-itermediate-2 -->
<reference value="Substance/fc178764-81d5-5656-9744-13c7ad1e595b"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueString value="Off-white solid"/>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:9c56948c-2a39-6609-2c01-4d197eb57a33"/>
<resource>
<Observation>
<!-- appearanceSubstance3 -->
<id value="9c56948c-2a39-6609-2c01-4d197eb57a33"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="9c56948c-2a39-6609-2c01-4d197eb57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "9c56948c-2a39-6609-2c01-4d197eb57a33" </p></div><p><b>instantiates</b>: <a href="#ObservationDefinition_fc07b5d5-9fe1-92c2-2d06-57cb5b295e72">See above (ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: Appearance <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq.html">CodeSystem - Example Local Codes - Drug</a>#Appearance)</span></p><p><b>subject</b>: <a href="#Substance_fc178764-81d6-5656-9744-13c7ad1e595b">See above (Substance/fc178764-81d6-5656-9744-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href="#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: Off-white solid</p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/AppearanceSubstance -->
<reference
value="ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq"/>
<code value="Appearance"/>
<display value="Appearance"/>
</coding>
<text value="Appearance"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-itermediate-3 -->
<reference value="Substance/fc178764-81d6-5656-9744-13c7ad1e595b"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueString value="Off-white solid"/>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:9c56958c-2a39-6609-2c01-4d197ea57a33"/>
<resource>
<Observation>
<!-- identificationSubstance1 -->
<id value="9c56958c-2a39-6609-2c01-4d197ea57a33"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="9c56958c-2a39-6609-2c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "9c56958c-2a39-6609-2c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href="#ObservationDefinition_3b1e878e-4bc9-8864-862f-e28b21233e8d">See above (ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d)</a></p><p><b>status</b>: final</p><p><b>code</b>: ID by HPLC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq.html">CodeSystem - Example Local Codes - Drug</a>#IDT "Identification")</span></p><p><b>subject</b>: <a href="#Substance_fc178763-81c5-5656-9744-13c7ad1e595b">See above (Substance/fc178763-81c5-5656-9744-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href="#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: Conforms</p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/IdentificationSubstance -->
<reference
value="ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq"/>
<code value="IDT"/>
<display value="Identification"/>
</coding>
<text value="ID by HPLC"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-itermediate-1 -->
<reference value="Substance/fc178763-81c5-5656-9744-13c7ad1e595b"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueString value="Conforms"/>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:9c56968c-2a49-6609-2c01-4d197ea57a33"/>
<resource>
<Observation>
<!-- identificationSubstance2 -->
<id value="9c56968c-2a49-6609-2c01-4d197ea57a33"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="9c56968c-2a49-6609-2c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "9c56968c-2a49-6609-2c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href="#ObservationDefinition_3b1e878e-4bc9-8864-862f-e28b21233e8d">See above (ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d)</a></p><p><b>status</b>: final</p><p><b>code</b>: ID by HPLC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq.html">CodeSystem - Example Local Codes - Drug</a>#IDT "Identification")</span></p><p><b>subject</b>: <a href="#Substance_fc178764-81d5-5656-9744-13c7ad1e595b">See above (Substance/fc178764-81d5-5656-9744-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href="#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: Conforms</p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/IdentificationSubstance -->
<reference
value="ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq"/>
<code value="IDT"/>
<display value="Identification"/>
</coding>
<text value="ID by HPLC"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-itermediate-2 -->
<reference value="Substance/fc178764-81d5-5656-9744-13c7ad1e595b"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueString value="Conforms"/>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:9c56978c-2a39-6609-2c01-4d197eb57a33"/>
<resource>
<Observation>
<!-- identificationSubstance3 -->
<id value="9c56978c-2a39-6609-2c01-4d197eb57a33"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="9c56978c-2a39-6609-2c01-4d197eb57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "9c56978c-2a39-6609-2c01-4d197eb57a33" </p></div><p><b>instantiates</b>: <a href="#ObservationDefinition_3b1e878e-4bc9-8864-862f-e28b21233e8d">See above (ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d)</a></p><p><b>status</b>: final</p><p><b>code</b>: ID by HPLC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq.html">CodeSystem - Example Local Codes - Drug</a>#IDT "Identification")</span></p><p><b>subject</b>: <a href="#Substance_fc178764-81d6-5656-9744-13c7ad1e595b">See above (Substance/fc178764-81d6-5656-9744-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href="#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: Does not conform</p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/IdentificationSubstance -->
<reference
value="ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq"/>
<code value="IDT"/>
<display value="Identification"/>
</coding>
<text value="ID by HPLC"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-itermediate-3 -->
<reference value="Substance/fc178764-81d6-5656-9744-13c7ad1e595b"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueString value="Does not conform"/>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:9c56948c-2a39-6609-1c01-4d197ea57a33"/>
<resource>
<Observation>
<!-- step1Yield1 -->
<id value="9c56948c-2a39-6609-1c01-4d197ea57a33"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="9c56948c-2a39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "9c56948c-2a39-6609-1c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href="#ObservationDefinition_fd17b5d6-9fe1-91c2-2d06-47cb5b295e72">See above (ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq.html">CodeSystem - Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: <a href="#Substance_fc178763-81c5-5656-9744-13c7ad1e595b">See above (Substance/fc178763-81c5-5656-9744-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href="#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 75 %</p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Step1Yield -->
<reference
value="ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq"/>
<code value="Yield (%)"/>
<display value="Yield (%)"/>
</coding>
<text value="Yield (%)"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-itermediate-1 -->
<reference value="Substance/fc178763-81c5-5656-9744-13c7ad1e595b"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="75"/>
<unit value="%"/>
</valueQuantity>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:9c56948a-2b39-6609-1c01-4d197ea57a33"/>
<resource>
<Observation>
<!-- step1Yield2 -->
<id value="9c56948a-2b39-6609-1c01-4d197ea57a33"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="9c56948a-2b39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "9c56948a-2b39-6609-1c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href="#ObservationDefinition_fd17b5d6-9fe1-91c2-2d06-47cb5b295e72">See above (ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq.html">CodeSystem - Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: <a href="#Substance_fc178764-81d5-5656-9744-13c7ad1e595b">See above (Substance/fc178764-81d5-5656-9744-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href="#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 77 %</p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Step1Yield -->
<reference
value="ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq"/>
<code value="Yield (%)"/>
<display value="Yield (%)"/>
</coding>
<text value="Yield (%)"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-itermediate-2 -->
<reference value="Substance/fc178764-81d5-5656-9744-13c7ad1e595b"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="77"/>
<unit value="%"/>
</valueQuantity>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:9c56948a-2a39-6609-1c01-4d197ea57a33"/>
<resource>
<Observation>
<!-- step1Yield3 -->
<id value="9c56948a-2a39-6609-1c01-4d197ea57a33"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="9c56948a-2a39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "9c56948a-2a39-6609-1c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href="#ObservationDefinition_fd17b5d6-9fe1-91c2-2d06-47cb5b295e72">See above (ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq.html">CodeSystem - Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: <a href="#Substance_fc178764-81d6-5656-9744-13c7ad1e595b">See above (Substance/fc178764-81d6-5656-9744-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href="#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 76 %</p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Step1Yield -->
<reference
value="ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq"/>
<code value="Yield (%)"/>
<display value="Yield (%)"/>
</coding>
<text value="Yield (%)"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-itermediate-3 -->
<reference value="Substance/fc178764-81d6-5656-9744-13c7ad1e595b"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="76"/>
<unit value="%"/>
</valueQuantity>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:9c56948d-2a39-6609-1c01-4d197ea57a33"/>
<resource>
<Observation>
<!-- step2Yield1 -->
<id value="9c56948d-2a39-6609-1c01-4d197ea57a33"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="9c56948d-2a39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "9c56948d-2a39-6609-1c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href="#ObservationDefinition_fd17b5d7-9fe1-91c2-2d06-47cb5b295e72">See above (ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq.html">CodeSystem - Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: <a href="#Substance_fc178763-81c5-5656-9754-13c7ad1e595b">See above (Substance/fc178763-81c5-5656-9754-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href="#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 85 %</p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Step2Yield -->
<reference
value="ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq"/>
<code value="Yield (%)"/>
<display value="Yield (%)"/>
</coding>
<text value="Yield (%)"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-itermediate-step2-1 -->
<reference value="Substance/fc178763-81c5-5656-9754-13c7ad1e595b"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="85"/>
<unit value="%"/>
</valueQuantity>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:9c56948c-2b39-6609-1c01-4d197ea57a33"/>
<resource>
<Observation>
<!-- step2Yield2 -->
<id value="9c56948c-2b39-6609-1c01-4d197ea57a33"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="9c56948c-2b39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "9c56948c-2b39-6609-1c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href="#ObservationDefinition_fd17b5d7-9fe1-91c2-2d06-47cb5b295e72">See above (ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq.html">CodeSystem - Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: <a href="#Substance_fc178764-81d5-5656-9764-13c7ad1e595b">See above (Substance/fc178764-81d5-5656-9764-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href="#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 87 %</p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Step2Yield -->
<reference
value="ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq"/>
<code value="Yield (%)"/>
<display value="Yield (%)"/>
</coding>
<text value="Yield (%)"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-itermediate-step2-2 -->
<reference value="Substance/fc178764-81d5-5656-9764-13c7ad1e595b"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="87"/>
<unit value="%"/>
</valueQuantity>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:9c56948b-2a39-6609-1c01-4d197ea57a33"/>
<resource>
<Observation>
<!-- step2Yield3 -->
<id value="9c56948b-2a39-6609-1c01-4d197ea57a33"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="9c56948b-2a39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "9c56948b-2a39-6609-1c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href="#ObservationDefinition_fd17b5d7-9fe1-91c2-2d06-47cb5b295e72">See above (ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq.html">CodeSystem - Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: <a href="#Substance_fc178764-81d6-6656-9744-13c7ad1e595b">See above (Substance/fc178764-81d6-6656-9744-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href="#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 86 %</p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Step2Yield -->
<reference
value="ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq"/>
<code value="Yield (%)"/>
<display value="Yield (%)"/>
</coding>
<text value="Yield (%)"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-itermediate-step2-3 -->
<reference value="Substance/fc178764-81d6-6656-9744-13c7ad1e595b"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="86"/>
<unit value="%"/>
</valueQuantity>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:9c56958c-2a39-6609-1c01-4d197ea57a33"/>
<resource>
<Observation>
<!-- residualWaterContent1 -->
<id value="9c56958c-2a39-6609-1c01-4d197ea57a33"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="9c56958c-2a39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "9c56958c-2a39-6609-1c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href="#ObservationDefinition_fc27b5d6-9fe1-91c2-2d16-57cb5b295e72">See above (ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: ResidualWaterContent (w/w%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq.html">CodeSystem - Example Local Codes - Drug</a>#ResidualWaterContent "Residual Water Content (w/w%)")</span></p><p><b>subject</b>: <a href="#Substance_fc178763-81c5-5656-9744-13c7ad1e595b">See above (Substance/fc178763-81c5-5656-9744-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href="#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 6.9 %</p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/ResidualWaterContent -->
<reference
value="ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq"/>
<code value="ResidualWaterContent"/>
<display value="Residual Water Content (w/w%)"/>
</coding>
<text value="ResidualWaterContent (w/w%)"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-itermediate-1 -->
<reference value="Substance/fc178763-81c5-5656-9744-13c7ad1e595b"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="6.9"/>
<unit value="%"/>
</valueQuantity>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:9c56968a-2b39-6609-1c01-4d197ea57a33"/>
<resource>
<Observation>
<!-- residualWaterContent2 -->
<id value="9c56968a-2b39-6609-1c01-4d197ea57a33"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="9c56968a-2b39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "9c56968a-2b39-6609-1c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href="#ObservationDefinition_fc27b5d6-9fe1-91c2-2d16-57cb5b295e72">See above (ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: ResidualWaterContent (w/w%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq.html">CodeSystem - Example Local Codes - Drug</a>#ResidualWaterContent "Residual Water Content (w/w%)")</span></p><p><b>subject</b>: <a href="#Substance_fc178764-81d5-5656-9744-13c7ad1e595b">See above (Substance/fc178764-81d5-5656-9744-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href="#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 7.0 %</p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/ResidualWaterContent -->
<reference
value="ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq"/>
<code value="ResidualWaterContent"/>
<display value="Residual Water Content (w/w%)"/>
</coding>
<text value="ResidualWaterContent (w/w%)"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-itermediate-2 -->
<reference value="Substance/fc178764-81d5-5656-9744-13c7ad1e595b"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="7.0"/>
<unit value="%"/>
</valueQuantity>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:9c56978a-2a39-6609-1c01-4d197ea57a33"/>
<resource>
<Observation>
<!-- residualWaterContent3 -->
<id value="9c56978a-2a39-6609-1c01-4d197ea57a33"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="9c56978a-2a39-6609-1c01-4d197ea57a33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "9c56978a-2a39-6609-1c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href="#ObservationDefinition_fc27b5d6-9fe1-91c2-2d16-57cb5b295e72">See above (ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: ResidualWaterContent (w/w%) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq.html">CodeSystem - Example Local Codes - Drug</a>#ResidualWaterContent "Residual Water Content (w/w%)")</span></p><p><b>subject</b>: <a href="#Substance_fc178764-81d6-5656-9744-13c7ad1e595b">See above (Substance/fc178764-81d6-5656-9744-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href="#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 6.8 %</p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/ResidualWaterContent -->
<reference
value="ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq"/>
<code value="ResidualWaterContent"/>
<display value="Residual Water Content (w/w%)"/>
</coding>
<text value="ResidualWaterContent (w/w%)"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-itermediate-3 -->
<reference value="Substance/fc178764-81d6-5656-9744-13c7ad1e595b"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="6.8"/>
<unit value="%"/>
</valueQuantity>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:23dbbd32-2962-9fc3-40b1-67e864f21cd2"/>
<resource>
<Organization>
<!-- substance-manufacturer -->
<id value="23dbbd32-2962-9fc3-40b1-67e864f21cd2"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Organization</b><a name="23dbbd32-2962-9fc3-40b1-67e864f21cd2"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Organization "23dbbd32-2962-9fc3-40b1-67e864f21cd2" </p></div><p><b>identifier</b>: id: 3003040516</p><p><b>name</b>: AAA Molybdenum Products, Inc.</p><h3>Contacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Address</b></td></tr><tr><td style="display: none">*</td><td>7233 W 116th Pl Ste C Broomfield Colorado 80020 USA </td></tr></table></div>
</text>
<identifier>
<!-- FDA establishment identifier -->
<system value="urn:oid:2.16.840.1.113883.4.82"/>
<value value="3003040516"/>
</identifier>
<name value="AAA Molybdenum Products, Inc."/>
<contact>
<address>
<line value="7233 W 116th Pl"/>
<line value="Ste C"/>
<city value="Broomfield"/>
<state value="Colorado"/>
<postalCode value="80020"/>
<country value="USA"/>
</address>
</contact>
</Organization>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:378fbe5f-5926-3a5c-4c64-5428df877b08"/>
<resource>
<Organization>
<!-- testing lab -->
<!-- 378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<id value="378fbe5f-5926-3a5c-4c64-5428df877b08"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Organization</b><a name="378fbe5f-5926-3a5c-4c64-5428df877b08"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Organization "378fbe5f-5926-3a5c-4c64-5428df877b08" </p></div><p><b>name</b>: Testing Lab</p></div>
</text>
<name value="Testing Lab"/>
</Organization>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:57a9af63-315d-1585-a261-0e337b289390"/>
<resource>
<SubstanceDefinition>
<!-- substancedefinition-component-substance-dxpq-ex1 -->
<id value="57a9af63-315d-1585-a261-0e337b289390"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/SubstanceDefinition-component-substance-drug-pq"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: SubstanceDefinition</b><a name="57a9af63-315d-1585-a261-0e337b289390"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition "57a9af63-315d-1585-a261-0e337b289390" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-SubstanceDefinition-component-substance-drug-pq.html">SubstanceDefinition - Component Substance Drug PQ</a></p></div><p><b>manufacturer</b>: <a href="#Organization_49d2f0c0-4b28-9271-8aaf-2996a8b9739c">See above (Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c)</a></p><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>Stelbatolol</td></tr></table></div>
</text>
<manufacturer>
<!-- Organization/organization-dxpq-ex1 -->
<reference
value="Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
</manufacturer>
<name>
<name value="Stelbatolol"/>
</name>
</SubstanceDefinition>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:c458791f-7cb8-428e-83f7-8a205f821153"/>
<resource>
<SubstanceDefinition>
<!-- startingMaterial -->
<id value="c458791f-7cb8-428e-83f7-8a205f821153"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: SubstanceDefinition</b><a name="c458791f-7cb8-428e-83f7-8a205f821153"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition "c458791f-7cb8-428e-83f7-8a205f821153" </p></div><p><b>manufacturer</b>: <a href="#Organization_23dbbd32-2962-9fc3-40b1-67e864f21cd2">See above (Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2)</a></p><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>Stelbatosubstance</td></tr></table></div>
</text>
<manufacturer>
<!-- Organization/substance-manufacturer -->
<reference
value="Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2"/>
</manufacturer>
<name>
<name value="Stelbatosubstance"/>
</name>
</SubstanceDefinition>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:fc178762-81c5-5656-9744-13c7ad1e595b"/>
<resource>
<Substance>
<!-- actual-batch-substance-starting-1 -->
<id value="fc178762-81c5-5656-9744-13c7ad1e595b"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Substance</b><a name="fc178762-81c5-5656-9744-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance "fc178762-81c5-5656-9744-13c7ad1e595b" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-01</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 8.1 kg</p></blockquote><p><b>identifier</b>: id: Start1Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td><a href="#SubstanceDefinition_c458791f-7cb8-428e-83f7-8a205f821153">See above (SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153)</a></td></tr></table></div>
</text>
<extension
url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
<extension url="manufacturingDate">
<valueDateTime value="2019-09-01"/>
</extension>
<extension url="batchQuantity">
<valueQuantity>
<value value="8.1"/>
<unit value="kg"/>
</valueQuantity>
</extension>
</extension>
<identifier>
<value value="Start1Amgen"/>
</identifier>
<instance value="true"/>
<code>
<reference>
<!-- SubstanceDefinition/startingMaterial -->
<reference
value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153"/>
</reference>
</code>
</Substance>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:fc178762-81d5-5656-9744-13c7ad1e595b"/>
<resource>
<Substance>
<!-- actual-batch-substance-starting-2 -->
<id value="fc178762-81d5-5656-9744-13c7ad1e595b"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Substance</b><a name="fc178762-81d5-5656-9744-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance "fc178762-81d5-5656-9744-13c7ad1e595b" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-01</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 8.2 kg</p></blockquote><p><b>identifier</b>: id: Start2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td><a href="#SubstanceDefinition_c458791f-7cb8-428e-83f7-8a205f821153">See above (SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153)</a></td></tr></table></div>
</text>
<extension
url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
<extension url="manufacturingDate">
<valueDateTime value="2019-09-01"/>
</extension>
<extension url="batchQuantity">
<valueQuantity>
<value value="8.2"/>
<unit value="kg"/>
</valueQuantity>
</extension>
</extension>
<identifier>
<value value="Start2Amgen"/>
</identifier>
<instance value="true"/>
<code>
<reference>
<!-- SubstanceDefinition/startingMaterial -->
<reference
value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153"/>
</reference>
</code>
</Substance>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:fc178762-81d5-5656-9744-23c7ad1e595b"/>
<resource>
<Substance>
<!-- actual-batch-substance-starting-3 -->
<id value="fc178762-81d5-5656-9744-23c7ad1e595b"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Substance</b><a name="fc178762-81d5-5656-9744-23c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance "fc178762-81d5-5656-9744-23c7ad1e595b" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-01</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 8.3 kg</p></blockquote><p><b>identifier</b>: id: Start3Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td><a href="#SubstanceDefinition_c458791f-7cb8-428e-83f7-8a205f821153">See above (SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153)</a></td></tr></table></div>
</text>
<extension
url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
<extension url="manufacturingDate">
<valueDateTime value="2019-09-01"/>
</extension>
<extension url="batchQuantity">
<valueQuantity>
<value value="8.3"/>
<unit value="kg"/>
</valueQuantity>
</extension>
</extension>
<identifier>
<value value="Start3Amgen"/>
</identifier>
<instance value="true"/>
<code>
<reference>
<!-- SubstanceDefinition/startingMaterial -->
<reference
value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153"/>
</reference>
</code>
</Substance>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:c458791f-7cb8-428e-83f7-8a205f821154"/>
<resource>
<SubstanceDefinition>
<!-- resultingMaterial -->
<id value="c458791f-7cb8-428e-83f7-8a205f821154"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: SubstanceDefinition</b><a name="c458791f-7cb8-428e-83f7-8a205f821154"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition "c458791f-7cb8-428e-83f7-8a205f821154" </p></div><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>Resultothane</td></tr></table></div>
</text>
<name>
<name value="Resultothane"/>
</name>
</SubstanceDefinition>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:c458791f-7cb8-428e-83f7-8a205f821155"/>
<resource>
<SubstanceDefinition>
<!-- intermediateMaterial -->
<id value="c458791f-7cb8-428e-83f7-8a205f821155"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: SubstanceDefinition</b><a name="c458791f-7cb8-428e-83f7-8a205f821155"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition "c458791f-7cb8-428e-83f7-8a205f821155" </p></div><p><b>manufacturer</b>: <a href="#Organization_23dbbd32-2962-9fc3-40b1-67e864f21cd2">See above (Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2)</a></p><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>Processohol</td></tr></table></div>
</text>
<manufacturer>
<!-- Organization/substance-manufacturer -->
<reference
value="Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2"/>
</manufacturer>
<name>
<name value="Processohol"/>
</name>
</SubstanceDefinition>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:fc178763-81c5-5656-9744-13c7ad1e595b"/>
<resource>
<Substance>
<!-- actual-batch-substance-itermediate-1 -->
<id value="fc178763-81c5-5656-9744-13c7ad1e595b"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Substance</b><a name="fc178763-81c5-5656-9744-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance "fc178763-81c5-5656-9744-13c7ad1e595b" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 9.1 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: <a href="#Substance_fc178762-81c5-5656-9744-13c7ad1e595b">See above (Substance/fc178762-81c5-5656-9744-13c7ad1e595b)</a></p><p><b>identifier</b>: id: Intermed1Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td><a href="#SubstanceDefinition_c458791f-7cb8-428e-83f7-8a205f821155">See above (SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155)</a></td></tr></table></div>
</text>
<extension
url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
<extension url="batchQuantity">
<valueQuantity>
<value value="9.1"/>
<unit value="kg"/>
</valueQuantity>
</extension>
</extension>
<!-- local extension -->
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq">
<!-- assumes 1 to 1, could also be done via a Procedure but overkill -->
<valueReference>
<!-- Substance/actual-batch-substance-starting-1 -->
<reference
value="Substance/fc178762-81c5-5656-9744-13c7ad1e595b"/>
</valueReference>
</extension>
<identifier>
<value value="Intermed1Amgen"/>
</identifier>
<instance value="true"/>
<code>
<reference>
<!-- SubstanceDefinition/intermediateMaterial -->
<reference
value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155"/>
</reference>
</code>
</Substance>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:fc178764-81d5-5656-9744-13c7ad1e595b"/>
<resource>
<Substance>
<!-- actual-batch-substance-itermediate-2 -->
<id value="fc178764-81d5-5656-9744-13c7ad1e595b"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Substance</b><a name="fc178764-81d5-5656-9744-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance "fc178764-81d5-5656-9744-13c7ad1e595b" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 9.2 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: <a href="#Substance_fc178762-81d5-5656-9744-13c7ad1e595b">See above (Substance/fc178762-81d5-5656-9744-13c7ad1e595b)</a></p><p><b>identifier</b>: id: Intermed2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td><a href="#SubstanceDefinition_c458791f-7cb8-428e-83f7-8a205f821155">See above (SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155)</a></td></tr></table></div>
</text>
<extension
url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
<extension url="batchQuantity">
<valueQuantity>
<value value="9.2"/>
<unit value="kg"/>
</valueQuantity>
</extension>
</extension>
<!-- local extension -->
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq">
<!-- assumes 1 to 1, could also be done via a Procedure but overkill -->
<valueReference>
<!-- Substance/actual-batch-substance-starting-2 -->
<reference
value="Substance/fc178762-81d5-5656-9744-13c7ad1e595b"/>
</valueReference>
</extension>
<identifier>
<value value="Intermed2Amgen"/>
</identifier>
<instance value="true"/>
<code>
<reference>
<!-- SubstanceDefinition/intermediateMaterial -->
<reference
value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155"/>
</reference>
</code>
</Substance>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:fc178764-81d6-5656-9744-13c7ad1e595b"/>
<resource>
<Substance>
<!-- actual-batch-substance-itermediate-3 -->
<id value="fc178764-81d6-5656-9744-13c7ad1e595b"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Substance</b><a name="fc178764-81d6-5656-9744-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance "fc178764-81d6-5656-9744-13c7ad1e595b" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 9.3 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: <a href="#Substance_fc178762-81d5-5656-9744-23c7ad1e595b">See above (Substance/fc178762-81d5-5656-9744-23c7ad1e595b)</a></p><p><b>identifier</b>: id: Intermed3Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td><a href="#SubstanceDefinition_c458791f-7cb8-428e-83f7-8a205f821155">See above (SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155)</a></td></tr></table></div>
</text>
<extension
url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
<extension url="batchQuantity">
<valueQuantity>
<value value="9.3"/>
<unit value="kg"/>
</valueQuantity>
</extension>
</extension>
<!-- local extension -->
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq">
<!-- assumes 1 to 1, could also be done via a Procedure but overkill -->
<valueReference>
<!-- Substance/actual-batch-substance-starting-3 -->
<reference
value="Substance/fc178762-81d5-5656-9744-23c7ad1e595b"/>
</valueReference>
</extension>
<identifier>
<value value="Intermed3Amgen"/>
</identifier>
<instance value="true"/>
<code>
<reference>
<!-- SubstanceDefinition/intermediateMaterial -->
<reference
value="SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155"/>
</reference>
</code>
</Substance>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:c458791f-8cb8-428e-83f7-8a205f821153"/>
<resource>
<SubstanceDefinition>
<!-- startingMaterialStep2 -->
<id value="c458791f-8cb8-428e-83f7-8a205f821153"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: SubstanceDefinition</b><a name="c458791f-8cb8-428e-83f7-8a205f821153"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition "c458791f-8cb8-428e-83f7-8a205f821153" </p></div><p><b>manufacturer</b>: <a href="#Organization_23dbbd32-2962-9fc3-40b1-67e864f21cd2">See above (Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2)</a></p><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>Stelbatosubstance2</td></tr></table></div>
</text>
<manufacturer>
<!-- Organization/substance-manufacturer -->
<reference
value="Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2"/>
</manufacturer>
<name>
<name value="Stelbatosubstance2"/>
</name>
</SubstanceDefinition>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:fc178762-81c5-5656-9744-13c7ad2e595b"/>
<resource>
<Substance>
<!-- actual-batch-substance-starting-step2-1 -->
<id value="fc178762-81c5-5656-9744-13c7ad2e595b"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Substance</b><a name="fc178762-81c5-5656-9744-13c7ad2e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance "fc178762-81c5-5656-9744-13c7ad2e595b" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-02</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 7.1 kg</p></blockquote><p><b>identifier</b>: id: Start1Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td><a href="#SubstanceDefinition_c458791f-8cb8-428e-83f7-8a205f821153">See above (SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153)</a></td></tr></table></div>
</text>
<extension
url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
<extension url="manufacturingDate">
<valueDateTime value="2019-09-02"/>
</extension>
<extension url="batchQuantity">
<valueQuantity>
<value value="7.1"/>
<unit value="kg"/>
</valueQuantity>
</extension>
</extension>
<identifier>
<value value="Start1Step2Amgen"/>
</identifier>
<instance value="true"/>
<code>
<reference>
<!-- SubstanceDefinition/startingMaterialStep2 -->
<reference
value="SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153"/>
</reference>
</code>
</Substance>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:fc178762-81d5-5656-9744-13c7ad1e596b"/>
<resource>
<Substance>
<!-- actual-batch-substance-starting-step2-2 -->
<id value="fc178762-81d5-5656-9744-13c7ad1e596b"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Substance</b><a name="fc178762-81d5-5656-9744-13c7ad1e596b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance "fc178762-81d5-5656-9744-13c7ad1e596b" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-02</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 7.2 kg</p></blockquote><p><b>identifier</b>: id: Start2Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td><a href="#SubstanceDefinition_c458791f-8cb8-428e-83f7-8a205f821153">See above (SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153)</a></td></tr></table></div>
</text>
<extension
url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
<extension url="manufacturingDate">
<valueDateTime value="2019-09-02"/>
</extension>
<extension url="batchQuantity">
<valueQuantity>
<value value="7.2"/>
<unit value="kg"/>
</valueQuantity>
</extension>
</extension>
<identifier>
<value value="Start2Step2Amgen"/>
</identifier>
<instance value="true"/>
<code>
<reference>
<!-- SubstanceDefinition/startingMaterialStep2 -->
<reference
value="SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153"/>
</reference>
</code>
</Substance>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:fc178762-81d5-5656-9744-23c7ad1e597b"/>
<resource>
<Substance>
<!-- actual-batch-substance-starting-step2-3 -->
<id value="fc178762-81d5-5656-9744-23c7ad1e597b"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Substance</b><a name="fc178762-81d5-5656-9744-23c7ad1e597b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance "fc178762-81d5-5656-9744-23c7ad1e597b" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-02</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 7.3 kg</p></blockquote><p><b>identifier</b>: id: Start3Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td><a href="#SubstanceDefinition_c458791f-8cb8-428e-83f7-8a205f821153">See above (SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153)</a></td></tr></table></div>
</text>
<extension
url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
<extension url="manufacturingDate">
<valueDateTime value="2019-09-02"/>
</extension>
<extension url="batchQuantity">
<valueQuantity>
<value value="7.3"/>
<unit value="kg"/>
</valueQuantity>
</extension>
</extension>
<identifier>
<value value="Start3Step2Amgen"/>
</identifier>
<instance value="true"/>
<code>
<reference>
<!-- SubstanceDefinition/startingMaterialStep2 -->
<reference
value="SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153"/>
</reference>
</code>
</Substance>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:c458791f-7cb8-428e-84f7-8a205f821155"/>
<resource>
<SubstanceDefinition>
<!-- intermediateMaterialStep2 -->
<id value="c458791f-7cb8-428e-84f7-8a205f821155"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: SubstanceDefinition</b><a name="c458791f-7cb8-428e-84f7-8a205f821155"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition "c458791f-7cb8-428e-84f7-8a205f821155" </p></div><p><b>manufacturer</b>: <a href="#Organization_23dbbd32-2962-9fc3-40b1-67e864f21cd2">See above (Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2)</a></p><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>ProcessoholStep2</td></tr></table></div>
</text>
<manufacturer>
<!-- Organization/substance-manufacturer -->
<reference
value="Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2"/>
</manufacturer>
<name>
<name value="ProcessoholStep2"/>
</name>
</SubstanceDefinition>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:fc178763-81c5-5656-9754-13c7ad1e595b"/>
<resource>
<Substance>
<!-- actual-batch-substance-itermediate-step2-1 -->
<id value="fc178763-81c5-5656-9754-13c7ad1e595b"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Substance</b><a name="fc178763-81c5-5656-9754-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance "fc178763-81c5-5656-9754-13c7ad1e595b" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 10.1 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: <a href="#Substance_fc178762-81c5-5656-9744-13c7ad2e595b">See above (Substance/fc178762-81c5-5656-9744-13c7ad2e595b)</a></p><p><b>identifier</b>: id: Intermed1Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td><a href="#SubstanceDefinition_c458791f-7cb8-428e-84f7-8a205f821155">See above (SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155)</a></td></tr></table></div>
</text>
<extension
url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
<extension url="batchQuantity">
<valueQuantity>
<value value="10.1"/>
<unit value="kg"/>
</valueQuantity>
</extension>
</extension>
<!-- local extension -->
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq">
<!-- assumes 1 to 1, could also be done via a Procedure but overkill -->
<valueReference>
<!-- Substance/actual-batch-substance-starting-step2-1 -->
<reference
value="Substance/fc178762-81c5-5656-9744-13c7ad2e595b"/>
</valueReference>
</extension>
<identifier>
<value value="Intermed1Step2Amgen"/>
</identifier>
<instance value="true"/>
<code>
<reference>
<!-- SubstanceDefinition/intermediateMaterialStep2 -->
<reference
value="SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155"/>
</reference>
</code>
</Substance>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:fc178764-81d5-5656-9764-13c7ad1e595b"/>
<resource>
<Substance>
<!-- actual-batch-substance-itermediate-step2-2 -->
<id value="fc178764-81d5-5656-9764-13c7ad1e595b"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Substance</b><a name="fc178764-81d5-5656-9764-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance "fc178764-81d5-5656-9764-13c7ad1e595b" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 10.2 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: <a href="#Substance_fc178762-81d5-5656-9744-13c7ad1e596b">See above (Substance/fc178762-81d5-5656-9744-13c7ad1e596b)</a></p><p><b>identifier</b>: id: Intermed2Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td><a href="#SubstanceDefinition_c458791f-7cb8-428e-84f7-8a205f821155">See above (SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155)</a></td></tr></table></div>
</text>
<extension
url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
<extension url="batchQuantity">
<valueQuantity>
<value value="10.2"/>
<unit value="kg"/>
</valueQuantity>
</extension>
</extension>
<!-- local extension -->
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq">
<!-- assumes 1 to 1, could also be done via a Procedure but overkill -->
<valueReference>
<!-- Substance/actual-batch-substance-starting-step2-2 -->
<reference
value="Substance/fc178762-81d5-5656-9744-13c7ad1e596b"/>
</valueReference>
</extension>
<identifier>
<value value="Intermed2Step2Amgen"/>
</identifier>
<instance value="true"/>
<code>
<reference>
<!-- SubstanceDefinition/intermediateMaterialStep2 -->
<reference
value="SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155"/>
</reference>
</code>
</Substance>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:fc178764-81d6-6656-9744-13c7ad1e595b"/>
<resource>
<Substance>
<!-- actual-batch-substance-itermediate-step2-3 -->
<id value="fc178764-81d6-6656-9744-13c7ad1e595b"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Substance</b><a name="fc178764-81d6-6656-9744-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance "fc178764-81d6-6656-9744-13c7ad1e595b" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 10.3 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: <a href="#Substance_fc178762-81d5-5656-9744-23c7ad1e597b">See above (Substance/fc178762-81d5-5656-9744-23c7ad1e597b)</a></p><p><b>identifier</b>: id: Intermed3Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td><a href="#SubstanceDefinition_c458791f-7cb8-428e-84f7-8a205f821155">See above (SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155)</a></td></tr></table></div>
</text>
<extension
url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
<extension url="batchQuantity">
<valueQuantity>
<value value="10.3"/>
<unit value="kg"/>
</valueQuantity>
</extension>
</extension>
<!-- local extension -->
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq">
<!-- assumes 1 to 1, could also be done via a Procedure but overkill -->
<valueReference>
<!-- Substance/actual-batch-substance-starting-step2-3 -->
<reference
value="Substance/fc178762-81d5-5656-9744-23c7ad1e597b"/>
</valueReference>
</extension>
<identifier>
<value value="Intermed3Step2Amgen"/>
</identifier>
<instance value="true"/>
<code>
<reference>
<!-- SubstanceDefinition/intermediateMaterialStep2 -->
<reference
value="SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155"/>
</reference>
</code>
</Substance>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:c458791f-8cb8-428e-83f7-8a205f821154"/>
<resource>
<SubstanceDefinition>
<!-- resultingMaterialStep2 -->
<id value="c458791f-8cb8-428e-83f7-8a205f821154"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: SubstanceDefinition</b><a name="c458791f-8cb8-428e-83f7-8a205f821154"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition "c458791f-8cb8-428e-83f7-8a205f821154" </p></div><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>ResultothaneStep2</td></tr></table></div>
</text>
<name>
<name value="ResultothaneStep2"/>
</name>
</SubstanceDefinition>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
<resource>
<Organization>
<!-- id value="substance-manufacturer"/ -->
<!-- organization-dxpq-ex1 -->
<id value="49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Organization-drug-pq"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Organization</b><a name="49d2f0c0-4b28-9271-8aaf-2996a8b9739c"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Organization "49d2f0c0-4b28-9271-8aaf-2996a8b9739c" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Organization-drug-pq.html">Organization - Drug PQ</a></p></div><p><b>identifier</b>: id: 3003040516</p><p><b>name</b>: AAA Molybdenum Products, Inc.</p><h3>Contacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Address</b></td></tr><tr><td style="display: none">*</td><td>7233 W 116th Pl Ste C Broomfield Colorado 80020 USA </td></tr></table></div>
</text>
<identifier>
<!-- FDA establishment identifier -->
<system value="urn:oid:2.16.840.1.113883.4.82"/>
<value value="3003040516"/>
</identifier>
<name value="AAA Molybdenum Products, Inc."/>
<contact>
<address>
<line value="7233 W 116th Pl"/>
<line value="Ste C"/>
<city value="Broomfield"/>
<state value="Colorado"/>
<postalCode value="80020"/>
<country value="USA"/>
</address>
</contact>
</Organization>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:fc078762-81c5-5656-9744-13c7ad1e595b"/>
<resource>
<Substance>
<!-- <id value="actual-batch-substance"/> -->
<!-- substance-dxpq-ex1-unlinked -->
<id value="fc078762-81c5-5656-9744-13c7ad1e595b"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Substance</b><a name="fc078762-81c5-5656-9744-13c7ad1e595b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance "fc078762-81c5-5656-9744-13c7ad1e595b" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Substance-drug-pq.html">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-07</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 5.1 kg</p><blockquote><p><b>url</b></p><code>batchUtilization</code></blockquote><p><b>value</b>: Development <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.0.0/CodeSystem-v3-nciThesaurus.html">NCI Thesaurus</a>#C133991)</span></p><blockquote><p><b>url</b></p><code>assignedManufacturer</code></blockquote><p><b>value</b>: <a href="#Organization_49d2f0c0-4b28-9271-8aaf-2996a8b9739c">See above (Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c)</a></p></blockquote><p><b>Extension - Batch Release Date PQ</b>: 2019-09-08</p><p><b>Extension - Batch Retest Date PQ</b>: 2022-09-08</p><p><b>Extension - Actual Yield PQ</b>: 4.8 kg</p><p><b>identifier</b>: id: SUB1Amgen, id: SUB1SiteA</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td><a href="#SubstanceDefinition_57a9af63-315d-1585-a261-0e337b289390">See above (SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390)</a></td></tr></table></div>
</text>
<extension
url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
<extension url="manufacturingDate">
<valueDateTime value="2019-09-07"/>
</extension>
<extension url="batchQuantity">
<valueQuantity>
<value value="5.1"/>
<unit value="kg"/>
</valueQuantity>
</extension>
<extension url="batchUtilization">
<valueCodeableConcept>
<coding>
<system
value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"/>
<code value="C133991"/>
<display value="Development"/>
</coding>
</valueCodeableConcept>
</extension>
<extension url="assignedManufacturer">
<valueReference>
<!-- Organization/organization-dxpq-ex1 -->
<reference
value="Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
</valueReference>
</extension>
</extension>
<!-- local extension -->
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq">
<valueDateTime value="2019-09-08"/>
</extension>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-retest-date-pq">
<valueDateTime value="2022-09-08"/>
</extension>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq">
<valueQuantity>
<value value="4.8"/>
<unit value="kg"/>
</valueQuantity>
</extension>
<identifier>
<value value="SUB1Amgen"/>
</identifier>
<identifier>
<value value="SUB1SiteA"/>
<assigner>
<!-- Organization/organization-dxpq-ex1 -->
<reference
value="Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
</assigner>
</identifier>
<instance value="true"/>
<code>
<reference>
<!-- SubstanceDefinition/substancedefinition-component-substance-dxpq-ex1 -->
<reference
value="SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390"/>
</reference>
</code>
</Substance>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:cb31d747-2338-88d5-342c-8e9c097e4dad"/>
<resource>
<Substance>
<!-- actual-batch-substance-2-unlinked -->
<id value="cb31d747-2338-88d5-342c-8e9c097e4dad"/>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Substance</b><a name="cb31d747-2338-88d5-342c-8e9c097e4dad"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance "cb31d747-2338-88d5-342c-8e9c097e4dad" </p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-07</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 5.2 kg</p><blockquote><p><b>url</b></p><code>batchUtilization</code></blockquote><p><b>value</b>: Development <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.0.0/CodeSystem-v3-nciThesaurus.html">NCI Thesaurus</a>#C133991)</span></p><blockquote><p><b>url</b></p><code>assignedManufacturer</code></blockquote><p><b>value</b>: <a href="#Organization_49d2f0c0-4b28-9271-8aaf-2996a8b9739c">See above (Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c)</a></p></blockquote><p><b>Extension - Batch Release Date PQ</b>: 2019-09-08</p><p><b>Extension - Batch Retest Date PQ</b>: 2022-09-08</p><p><b>Extension - Actual Yield PQ</b>: 4.8 kg</p><p><b>identifier</b>: id: SUB2Amgen, id: SUB2SiteA</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td><a href="#SubstanceDefinition_57a9af63-315d-1585-a261-0e337b289390">See above (SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390)</a></td></tr></table></div>
</text>
<extension
url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
<extension url="manufacturingDate">
<valueDateTime value="2019-09-07"/>
</extension>
<extension url="batchQuantity">
<valueQuantity>
<value value="5.2"/>
<unit value="kg"/>
</valueQuantity>
</extension>
<extension url="batchUtilization">
<valueCodeableConcept>
<coding>
<system
value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"/>
<code value="C133991"/>
<display value="Development"/>
</coding>
</valueCodeableConcept>
</extension>
<extension url="assignedManufacturer">
<valueReference>
<!-- Organization/organization-dxpq-ex1 -->
<reference
value="Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
</valueReference>
</extension>
</extension>
<!-- local extensions -->
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq">
<valueDateTime value="2019-09-08"/>
</extension>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-retest-date-pq">
<valueDateTime value="2022-09-08"/>
</extension>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq">
<valueQuantity>
<value value="4.8"/>
<unit value="kg"/>
</valueQuantity>
</extension>
<identifier>
<value value="SUB2Amgen"/>
</identifier>
<identifier>
<value value="SUB2SiteA"/>
<assigner>
<!-- Organization/organization-dxpq-ex1 -->
<reference
value="Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
</assigner>
</identifier>
<instance value="true"/>
<code>
<reference>
<!-- SubstanceDefinition/substancedefinition-component-substance-dxpq-ex1 -->
<reference
value="SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390"/>
</reference>
</code>
</Substance>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:1551f97b-6f6d-825e-1fb3-44b0b090808c"/>
<resource>
<Substance>
<!-- actual-batch-substance-3-unlinked -->
<id value="1551f97b-6f6d-825e-1fb3-44b0b090808c"/>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Substance</b><a name="1551f97b-6f6d-825e-1fb3-44b0b090808c"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance "1551f97b-6f6d-825e-1fb3-44b0b090808c" </p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-07</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 5.3 kg</p><blockquote><p><b>url</b></p><code>batchUtilization</code></blockquote><p><b>value</b>: Development <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.0.0/CodeSystem-v3-nciThesaurus.html">NCI Thesaurus</a>#C133991)</span></p><blockquote><p><b>url</b></p><code>assignedManufacturer</code></blockquote><p><b>value</b>: <a href="#Organization_49d2f0c0-4b28-9271-8aaf-2996a8b9739c">See above (Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c)</a></p></blockquote><p><b>Extension - Batch Release Date PQ</b>: 2019-09-08</p><p><b>Extension - Batch Retest Date PQ</b>: 2022-09-08</p><p><b>Extension - Actual Yield PQ</b>: 4.8 kg</p><p><b>identifier</b>: id: SUB3Amgen, id: SUB3SiteA</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td><a href="#SubstanceDefinition_57a9af63-315d-1585-a261-0e337b289390">See above (SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390)</a></td></tr></table></div>
</text>
<extension
url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
<extension url="manufacturingDate">
<valueDateTime value="2019-09-07"/>
</extension>
<extension url="batchQuantity">
<valueQuantity>
<value value="5.3"/>
<unit value="kg"/>
</valueQuantity>
</extension>
<extension url="batchUtilization">
<valueCodeableConcept>
<coding>
<system
value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"/>
<code value="C133991"/>
<display value="Development"/>
</coding>
</valueCodeableConcept>
</extension>
<extension url="assignedManufacturer">
<valueReference>
<!-- Organization/organization-dxpq-ex1 -->
<reference
value="Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
</valueReference>
</extension>
</extension>
<!-- local extensions -->
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq">
<valueDateTime value="2019-09-08"/>
</extension>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-retest-date-pq">
<valueDateTime value="2022-09-08"/>
</extension>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq">
<valueQuantity>
<value value="4.8"/>
<unit value="kg"/>
</valueQuantity>
</extension>
<identifier>
<value value="SUB3Amgen"/>
</identifier>
<identifier>
<value value="SUB3SiteA"/>
<assigner>
<!-- Organization/organization-dxpq-ex1 -->
<reference
value="Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"/>
</assigner>
</identifier>
<instance value="true"/>
<code>
<reference>
<!-- SubstanceDefinition/substancedefinition-component-substance-dxpq-ex1 -->
<reference
value="SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390"/>
</reference>
</code>
</Substance>
</resource>
</entry>
</Bundle>
IG © HL7 International / Biomedical Research and Regulation. Package hl7.fhir.uv.pharm-quality#1.0.0-ballot based on FHIR 5.0.0. Generated 2023-12-18
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