Pharmaceutical Quality (Industry)
1.0.0-ballot - ballot
Pharmaceutical Quality (Industry)
1.0.0-ballot - ballot
This page is part of the Pharmaceutical Quality (Industry) (v1.0.0-ballot: STU1 Ballot 1) based on FHIR (HL7® FHIR® Standard) v5.0.0. . For a full list of available versions, see the Directory of published versions
{
"resourceType" : "Bundle",
"id" : "bundle-product-process-validation-pq-ex2-sub",
"meta" : // Substance Process Validation
{
"profile" : [
🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Bundle-product-process-validation-pq"
]
},
"type" : "collection",
"entry" : [
{
"fullUrl" : "urn:uuid:2038e4c7-22b8-4c56-2d28-6c077648763f",
"resource" : {
"resourceType" : "PlanDefinition",
"id" : "2038e4c7-22b8-4c56-2d28-6c077648763f",
"text" : // validationProtocol
{
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: PlanDefinition</b><a name=\"2038e4c7-22b8-4c56-2d28-6c077648763f\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource PlanDefinition "2038e4c7-22b8-4c56-2d28-6c077648763f" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f</code></p><p><b>title</b>: DP PROCESS VALIDATION</p><p><b>type</b>: Workflow Definition <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.0.0/CodeSystem-plan-definition-type.html\">PlanDefinitionType</a>#workflow-definition; <a href=\"CodeSystem-cs-planType-local-pq.html\">CodeSystem - Plan Type</a>#process-validation "Process Validation")</span></p><p><b>status</b>: active</p><p><b>subject</b>: <a href=\"#SubstanceDefinition_57a9af63-315d-1585-a261-0e337b289390\">See above (SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390)</a></p><p><b>description</b>: Pre-defined validation acceptance criteria were established based on manufacturing development data derived from process characterization studies...</p><blockquote><p><b>action</b></p><p><b>Extension - Process Step Scale PQ</b>: Production Scale (Details: http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStepScale-local-pq code PROD = 'Production Scale', stated as 'Production Scale')</p><blockquote><p><b>Extension - Process Parameters PQ</b></p><blockquote><p><b>url</b></p><code>parameter</code></blockquote><p><b>value</b>: Mix speed <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-processParameter-local-pq.html\">CodeSystem - Process Parameter</a>#SPEED)</span></p><blockquote><p><b>url</b></p><code>value</code></blockquote><p><b>value</b>: 1500 rpm</p></blockquote><p><b>prefix</b>: 1</p><p><b>title</b>: Step 1 Yield</p><p><b>description</b>: Description of this step</p><p><b>code</b>: Particle Size Reduction <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-manufacturingStep-local-pq.html\">CodeSystem - Manufacturing Step</a>#particleSizeReduction)</span></p><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Starting material</span></p><p><b>role</b>: Starting Material <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-manufacturingParticipantRole-local-pq.html\">CodeSystem - Manufacturing Participant Role</a>#StartingMaterial)</span></p></blockquote><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Intermediate material</span></p><p><b>role</b>: Intermediate Material <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-manufacturingParticipantRole-local-pq.html\">CodeSystem - Manufacturing Participant Role</a>#IntermediateMaterial)</span></p></blockquote><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Resulting material</span></p><p><b>role</b>: Resulting Material <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-manufacturingParticipantRole-local-pq.html\">CodeSystem - Manufacturing Participant Role</a>#ResultingMaterial)</span></p></blockquote><h3>Actions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><code>ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72</code></td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: Step 1 In-Process Control Data</p><p><b>code</b>: Step 1 In-Process Control Data <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-manufacturingStep-local-pq.html\">CodeSystem - Manufacturing Step</a>#Step1In-ProcessControlData)</span></p><h3>Actions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><code>ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72</code></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><code>ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72</code></td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>title</b>: Step 1 DS Release Testing Results</p><p><b>code</b>: Step 1 DS Release Testing Results <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-manufacturingStep-local-pq.html\">CodeSystem - Manufacturing Step</a>#Step1DSReleaseTestingResults)</span></p><h3>Actions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><code>ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72</code></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><code>ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d</code></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><code>ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e</code></td></tr></table></blockquote><blockquote><p><b>action</b></p><p><b>Extension - Process Step Scale PQ</b>: Production Scale (Details: http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStepScale-local-pq code PROD = 'Production Scale', stated as 'Production Scale')</p><p><b>prefix</b>: 2</p><p><b>title</b>: Step 2 Yield</p><p><b>description</b>: Description of this step</p><p><b>code</b>: Drying <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-manufacturingStep-local-pq.html\">CodeSystem - Manufacturing Step</a>#drying)</span></p><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Starting material</span></p><p><b>role</b>: Starting Material <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-manufacturingParticipantRole-local-pq.html\">CodeSystem - Manufacturing Participant Role</a>#StartingMaterial)</span></p></blockquote><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Intermediate material</span></p><p><b>role</b>: Intermediate Material <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-manufacturingParticipantRole-local-pq.html\">CodeSystem - Manufacturing Participant Role</a>#IntermediateMaterial)</span></p></blockquote><blockquote><p><b>participant</b></p><p><b>typeReference</b>: <span>: Resulting material</span></p><p><b>role</b>: Resulting Material <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-manufacturingParticipantRole-local-pq.html\">CodeSystem - Manufacturing Participant Role</a>#ResultingMaterial)</span></p></blockquote><h3>Actions</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>Test <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td><code>ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72</code></td></tr></table></blockquote></div>"
},
"url" : "http://example-server.com/fhir/PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f",
"title" : "DP PROCESS VALIDATION",
"type" : // http://example-server.com/fhir/PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f
{
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/plan-definition-type",
"code" : "workflow-definition",
"display" : "Workflow Definition"
},
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-planType-local-pq",
"code" : "process-validation",
"display" : "Process Validation"
}
]
},
"status" : "active",
"subjectReference" : {
"reference" : "SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390"
},
"description" : "Pre-defined validation acceptance criteria were established based on manufacturing development data derived from process characterization studies...",
"action" : [
// SubstanceDefinition/substancedefinition-component-substance-dxpq-ex1
{
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-process-step-scale-pq",
"valueCoding" : {
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStepScale-local-pq",
"code" : "PROD",
"display" : "Production Scale"
}
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-process-parameters-pq",
"extension" : [
{
"url" : "parameter",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-processParameter-local-pq",
"code" : "SPEED",
"display" : "Mix speed"
}
]
}
},
{
"url" : "value",
"valueQuantity" : {
"value" : 1500,
"unit" : "rpm"
}
}
]
}
],
"prefix" : "1",
"title" : "Step 1 Yield",
"description" : "Description of this step",
"code" : // text value="Step 2 in the process - free text is possible"/
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStep-local-pq",
"code" : "particleSizeReduction",
"display" : "Particle Size Reduction"
}
]
},
"participant" : [
{
"typeReference" : {
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq",
"valueReference" : {
"reference" : "SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153"
}
}
],
"display" : "Starting material"
},
"role" : // SubstanceDefinition/startingMaterial
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingParticipantRole-local-pq",
"code" : "StartingMaterial",
"display" : "Starting Material"
}
]
}
},
{
"typeReference" : {
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq",
"valueReference" : {
"reference" : "SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155"
}
}
],
"display" : "Intermediate material"
},
"role" : // SubstanceDefinition/intermediateMaterial
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingParticipantRole-local-pq",
"code" : "IntermediateMaterial",
"display" : "Intermediate Material"
}
]
}
},
{
"typeReference" : {
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq",
"valueReference" : {
"reference" : "SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821154"
}
}
],
"display" : "Resulting material"
},
"role" : // SubstanceDefinition/resultingMaterial
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingParticipantRole-local-pq",
"code" : "ResultingMaterial",
"display" : "Resulting Material"
}
]
}
}
],
"action" : [
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"
}
]
},
// ObservationDefinition/Step1Yield
{
"title" : "Step 1 In-Process Control Data",
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStep-local-pq",
"code" : "Step1In-ProcessControlData",
"display" : "Step 1 In-Process Control Data"
}
]
},
"action" : [
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"
},
// ObservationDefinition/ResidualWaterContent
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72"
}
]
},
// ObservationDefinition/ResidualStartingMaterial1byHPLC
{
"title" : "Step 1 DS Release Testing Results",
"code" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStep-local-pq",
"code" : "Step1DSReleaseTestingResults",
"display" : "Step 1 DS Release Testing Results"
}
]
},
"action" : [
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"
},
// ObservationDefinition/AppearanceSubstance
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d"
},
// ObservationDefinition/IdentificationSubstance
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e"
}
]
},
// ObservationDefinition/AssaySubstance
{
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-process-step-scale-pq",
"valueCoding" : {
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStepScale-local-pq",
"code" : "PROD",
"display" : "Production Scale"
}
}
],
"prefix" : "2",
"title" : "Step 2 Yield",
"description" : "Description of this step",
"code" : // text value="Step 2 in the process - free text is possible"/
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingStep-local-pq",
"code" : "drying",
"display" : "Drying"
}
]
},
"participant" : [
{
"typeReference" : {
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq",
"valueReference" : {
"reference" : "SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153"
}
}
],
"display" : "Starting material"
},
"role" : // SubstanceDefinition/startingMaterialStep2
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingParticipantRole-local-pq",
"code" : "StartingMaterial",
"display" : "Starting Material"
}
]
}
},
{
"typeReference" : {
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq",
"valueReference" : {
"reference" : "SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155"
}
}
],
"display" : "Intermediate material"
},
"role" : // SubstanceDefinition/intermediateMaterialStep2
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingParticipantRole-local-pq",
"code" : "IntermediateMaterial",
"display" : "Intermediate Material"
}
]
}
},
{
"typeReference" : {
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-participant-pq",
"valueReference" : {
"reference" : "SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821154"
}
}
],
"display" : "Resulting material"
},
"role" : // SubstanceDefinition/resultingMaterialStep2
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-manufacturingParticipantRole-local-pq",
"code" : "ResultingMaterial",
"display" : "Resulting Material"
}
]
}
}
],
"action" : [
{
"code" : {
"text" : "Test"
},
"definitionCanonical" : "ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"
}
]
}
]
}
},
// ObservationDefinition/Step2Yield
{
"fullUrl" : "urn:uuid:b664977d-799d-a1ce-928a-5def2a9955bd",
"resource" : {
"resourceType" : "DiagnosticReport",
"id" : "processValidationReport",
"text" : // ideally this wants a subject, but it can only be a Medication (batch) and we have multiple.
however the observations themselves do have subjects
{
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: DiagnosticReport</b><a name=\"processValidationReport\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource DiagnosticReport "processValidationReport" </p></div><p><b>Triggered by</b>: <a href=\"#PlanDefinition_2038e4c7-22b8-4c56-2d28-6c077648763f\">See above (PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f)</a></p><p><b>status</b>: final</p><p><b>code</b>: Process Validation Report <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-reportType-local-pq.html\">CodeSystem - Report Type</a>#Process Validation Report)</span></p><p><b>effective</b>: 2020-12</p><p><b>result</b>: </p><ul><li><a href=\"#Observation_9c56948c-2a39-6609-1c01-4d197ea57a33\">See above (Observation/9c56948c-2a39-6609-1c01-4d197ea57a33)</a></li><li><a href=\"#Observation_9c56948a-2b39-6609-1c01-4d197ea57a33\">See above (Observation/9c56948a-2b39-6609-1c01-4d197ea57a33)</a></li><li><a href=\"#Observation_9c56948a-2a39-6609-1c01-4d197ea57a33\">See above (Observation/9c56948a-2a39-6609-1c01-4d197ea57a33)</a></li><li><a href=\"#Observation_9c56958c-2a39-6609-1c01-4d197ea57a33\">See above (Observation/9c56958c-2a39-6609-1c01-4d197ea57a33)</a></li><li><a href=\"#Observation_9c56968a-2b39-6609-1c01-4d197ea57a33\">See above (Observation/9c56968a-2b39-6609-1c01-4d197ea57a33)</a></li><li><a href=\"#Observation_9c56978a-2a39-6609-1c01-4d197ea57a33\">See above (Observation/9c56978a-2a39-6609-1c01-4d197ea57a33)</a></li><li><a href=\"#Observation_9c56948c-2a39-6609-2c01-4d197ea57a33\">See above (Observation/9c56948c-2a39-6609-2c01-4d197ea57a33)</a></li><li><a href=\"#Observation_9c56948c-2a49-6609-2c01-4d197ea57a33\">See above (Observation/9c56948c-2a49-6609-2c01-4d197ea57a33)</a></li><li><a href=\"#Observation_9c56948c-2a39-6609-2c01-4d197eb57a33\">See above (Observation/9c56948c-2a39-6609-2c01-4d197eb57a33)</a></li><li><a href=\"#Observation_9c56958c-2a39-6609-2c01-4d197ea57a33\">See above (Observation/9c56958c-2a39-6609-2c01-4d197ea57a33)</a></li><li><a href=\"#Observation_9c56968c-2a49-6609-2c01-4d197ea57a33\">See above (Observation/9c56968c-2a49-6609-2c01-4d197ea57a33)</a></li><li><a href=\"#Observation_9c56978c-2a39-6609-2c01-4d197eb57a33\">See above (Observation/9c56978c-2a39-6609-2c01-4d197eb57a33)</a></li><li><a href=\"#Observation_9c56948d-2a39-6609-1c01-4d197ea57a33\">See above (Observation/9c56948d-2a39-6609-1c01-4d197ea57a33)</a></li><li><a href=\"#Observation_9c56948c-2b39-6609-1c01-4d197ea57a33\">See above (Observation/9c56948c-2b39-6609-1c01-4d197ea57a33)</a></li><li><a href=\"#Observation_9c56948b-2a39-6609-1c01-4d197ea57a33\">See above (Observation/9c56948b-2a39-6609-1c01-4d197ea57a33)</a></li></ul><p><b>conclusion</b>: The samples have been assessed and the conclusion is...</p></div>"
},
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/workflow-triggeredBy",
"valueReference" : {
"reference" : "PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f"
}
}
],
"status" : "final",
"code" : // PlanDefinition/validationProtocol
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-reportType-local-pq",
"code" : "Process Validation Report",
"display" : "Process Validation Report"
}
]
},
"effectiveDateTime" : "2020-12",
"result" : [
{
"reference" : "Observation/9c56948c-2a39-6609-1c01-4d197ea57a33"
},
// Observation/step1Yield1
{
"reference" : "Observation/9c56948a-2b39-6609-1c01-4d197ea57a33"
},
// Observation/step1Yield2
{
"reference" : "Observation/9c56948a-2a39-6609-1c01-4d197ea57a33"
},
// Observation/step1Yield3
{
"reference" : "Observation/9c56958c-2a39-6609-1c01-4d197ea57a33"
},
// Observation/residualWaterContent1
{
"reference" : "Observation/9c56968a-2b39-6609-1c01-4d197ea57a33"
},
// Observation/residualWaterContent2
{
"reference" : "Observation/9c56978a-2a39-6609-1c01-4d197ea57a33"
},
// Observation/residualWaterContent3
{
"reference" : "Observation/9c56948c-2a39-6609-2c01-4d197ea57a33"
},
// Observation/appearanceSubstance1
{
"reference" : "Observation/9c56948c-2a49-6609-2c01-4d197ea57a33"
},
// Observation/appearanceSubstance2
{
"reference" : "Observation/9c56948c-2a39-6609-2c01-4d197eb57a33"
},
// Observation/appearanceSubstance3
{
"reference" : "Observation/9c56958c-2a39-6609-2c01-4d197ea57a33"
},
// Observation/identificationSubstance1
{
"reference" : "Observation/9c56968c-2a49-6609-2c01-4d197ea57a33"
},
// Observation/identificationSubstance2
{
"reference" : "Observation/9c56978c-2a39-6609-2c01-4d197eb57a33"
},
// Observation/identificationSubstance3
{
"reference" : "Observation/9c56948d-2a39-6609-1c01-4d197ea57a33"
},
// Observation/step2Yield1
{
"reference" : "Observation/9c56948c-2b39-6609-1c01-4d197ea57a33"
},
// Observation/step2Yield2
{
"reference" : "Observation/9c56948b-2a39-6609-1c01-4d197ea57a33"
}
],
"conclusion" : "The samples have been assessed and the conclusion is..."
}
},
// Observation/step2Yield3
{
"fullUrl" : "urn:uuid:fc07b5d5-9fe1-92c2-2d06-57cb5b295e72",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "fc07b5d5-9fe1-92c2-2d06-57cb5b295e72",
"text" : // AppearanceSubstance
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"fc07b5d5-9fe1-92c2-2d06-57cb5b295e72\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "fc07b5d5-9fe1-92c2-2d06-57cb5b295e72" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72</code></p><p><b>title</b>: Appearance</p><p><b>status</b>: active</p><p><b>code</b>: Appearance <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Appearance)</span></p><p><b>method</b>: Visual inspection <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Extension</b></td></tr><tr><td style=\"display: none\">*</td><td/></tr></table></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72",
"title" : "Appearance",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Appearance",
"display" : "Appearance"
}
],
"text" : "Appearance"
},
"method" : {
"text" : "Visual inspection"
},
"qualifiedValue" : [
{
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-text-pq",
"valueString" : "White to off-white, to red, to orange, to brown solid"
}
]
}
]
}
},
{
"fullUrl" : "urn:uuid:3b1e878e-4bc9-8864-862f-e28b21233e8d",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "3b1e878e-4bc9-8864-862f-e28b21233e8d",
"text" : // IdentificationSubstance
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"3b1e878e-4bc9-8864-862f-e28b21233e8d\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "3b1e878e-4bc9-8864-862f-e28b21233e8d" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d</code></p><p><b>title</b>: ID by HPLC</p><p><b>status</b>: active</p><p><b>code</b>: ID by HPLC <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#IDT "Identification")</span></p><p><b>method</b>: ID by UHPLC <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Extension</b></td></tr><tr><td style=\"display: none\">*</td><td/></tr></table></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d",
"title" : "ID by HPLC",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "IDT",
"display" : "Identification"
}
],
"text" : "ID by HPLC"
},
"method" : {
"text" : "ID by UHPLC"
},
"qualifiedValue" : [
{
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-text-pq",
"valueString" : "Conforms to standard"
}
]
}
]
}
},
{
"fullUrl" : "urn:uuid:12e7e672-40a6-4036-3c1f-b8ba6a7d045e",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "12e7e672-40a6-4036-3c1f-b8ba6a7d045e",
"text" : // AssaySubstance
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"12e7e672-40a6-4036-3c1f-b8ba6a7d045e\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "12e7e672-40a6-4036-3c1f-b8ba6a7d045e" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e</code></p><p><b>title</b>: Assay by HPLC (as is) (w/w%)</p><p><b>status</b>: active</p><p><b>code</b>: Assay by HPLC (as is) (w/w%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#ASSAY "Assay")</span></p><p><b>method</b>: Assay by UHPLC <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td>95-101 %</td></tr></table></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e",
"title" : "Assay by HPLC (as is) (w/w%)",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/12e7e672-40a6-4036-3c1f-b8ba6a7d045e
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "ASSAY",
"display" : "Assay"
}
],
"text" : "Assay by HPLC (as is) (w/w%)"
},
"method" : {
"text" : "Assay by UHPLC"
},
"qualifiedValue" : [
{
"range" : {
"low" : {
"value" : 95,
"unit" : "%",
"system" : "http://unitsofmeasure.org",
"code" : "%"
},
"high" : {
"value" : 101,
"unit" : "%",
"system" : "http://unitsofmeasure.org",
"code" : "%"
}
}
}
]
}
},
{
"fullUrl" : "urn:uuid:fd17b5d6-9fe1-91c2-2d06-47cb5b295e72",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "fd17b5d6-9fe1-91c2-2d06-47cb5b295e72",
"text" : // Step1Yield
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"fd17b5d6-9fe1-91c2-2d06-47cb5b295e72\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "fd17b5d6-9fe1-91c2-2d06-47cb5b295e72" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72</code></p><p><b>title</b>: Yield (%)</p><p><b>status</b>: active</p><p><b>code</b>: Yield (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Yield (%))</span></p></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72",
"title" : "Yield (%)",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Yield (%)",
"display" : "Yield (%)"
}
],
"text" : "Yield (%)"
}
}
},
{
"fullUrl" : "urn:uuid:fd17b5d7-9fe1-91c2-2d06-47cb5b295e72",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "fd17b5d7-9fe1-91c2-2d06-47cb5b295e72",
"text" : // Step2Yield
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"fd17b5d7-9fe1-91c2-2d06-47cb5b295e72\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "fd17b5d7-9fe1-91c2-2d06-47cb5b295e72" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72</code></p><p><b>title</b>: Yield (%)</p><p><b>status</b>: active</p><p><b>code</b>: Yield (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Yield (%))</span></p></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72",
"title" : "Yield (%)",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Yield (%)",
"display" : "Yield (%)"
}
],
"text" : "Yield (%)"
}
}
},
{
"fullUrl" : "urn:uuid:fc27b5d6-9fe1-91c2-2d16-57cb5b295e72",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "fc27b5d6-9fe1-91c2-2d16-57cb5b295e72",
"text" : // ResidualWaterContent
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"fc27b5d6-9fe1-91c2-2d16-57cb5b295e72\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "fc27b5d6-9fe1-91c2-2d16-57cb5b295e72" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72</code></p><p><b>title</b>: Residual Water Content (w/w%)</p><p><b>status</b>: active</p><p><b>code</b>: Residual Water Content (w/w%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#ResidualWaterContent)</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Extension</b></td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td/><td>?-7.15</td></tr></table></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72",
"title" : "Residual Water Content (w/w%)",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "ResidualWaterContent",
"display" : "Residual Water Content (w/w%)"
}
],
"text" : "Residual Water Content (w/w%)"
},
"qualifiedValue" : [
{
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-criticality-pq",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-qualifiedValueCriticality-local-pq",
"code" : "Non-critical",
"display" : "Non-critical"
}
],
"text" : "Non-critical"
}
}
],
"range" : {
"high" : {
"value" : 7.15,
"unit" : "%",
"system" : "http://unitsofmeasure.org",
"code" : "%"
}
}
}
]
}
},
{
"fullUrl" : "urn:uuid:fc27b5d6-9ff1-91c2-2d16-57cb5b295e72",
"resource" : {
"resourceType" : "ObservationDefinition",
"id" : "fc27b5d6-9ff1-91c2-2d16-57cb5b295e72",
"text" : // ResidualStartingMaterial1byHPLC
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: ObservationDefinition</b><a name=\"fc27b5d6-9ff1-91c2-2d16-57cb5b295e72\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ObservationDefinition "fc27b5d6-9ff1-91c2-2d16-57cb5b295e72" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72</code></p><p><b>title</b>: Reaction conversion: residual starting material 1 by HPLC (Step Aa) (LC area %)</p><p><b>status</b>: active</p><p><b>code</b>: Reaction conversion: Residual Starting Material 1 by HPLC <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Reaction conversion: Residual Starting Material 1 by HPLC)</span></p><h3>QualifiedValues</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Extension</b></td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td/><td>?-23</td></tr></table></div>"
},
"url" : "http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72",
"title" : "Reaction conversion: residual starting material 1 by HPLC (Step Aa) (LC area %)",
"status" : "active",
"code" : // http://example-server.com/fhir/ObservationDefinition/fc27b5d6-9ff1-91c2-2d16-57cb5b295e72
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Reaction conversion: Residual Starting Material 1 by HPLC",
"display" : "Reaction conversion: Residual Starting Material 1 by HPLC"
}
],
"text" : "Reaction conversion: Residual Starting Material 1 by HPLC"
},
"qualifiedValue" : [
{
"extension" : [
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-criticality-pq",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-qualifiedValueCriticality-local-pq",
"code" : "critical",
"display" : "Critical"
}
],
"text" : "Critical"
}
}
],
"range" : {
"high" : {
"value" : 23,
"unit" : "%",
"system" : "http://unitsofmeasure.org",
"code" : "%"
}
}
}
]
}
},
{
"fullUrl" : "urn:uuid:9c56948c-2a39-6609-2c01-4d197ea57a33",
"resource" : {
"resourceType" : "Observation",
"id" : "9c56948c-2a39-6609-2c01-4d197ea57a33",
"text" : // appearanceSubstance1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"9c56948c-2a39-6609-2c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "9c56948c-2a39-6609-2c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_fc07b5d5-9fe1-92c2-2d06-57cb5b295e72\">See above (ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: Appearance <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Appearance)</span></p><p><b>subject</b>: <a href=\"#Substance_fc178763-81c5-5656-9744-13c7ad1e595b\">See above (Substance/fc178763-81c5-5656-9744-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: Off-white solid</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"
},
"status" : "final",
"code" : // ObservationDefinition/AppearanceSubstance
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Appearance",
"display" : "Appearance"
}
],
"text" : "Appearance"
},
"subject" : {
"reference" : "Substance/fc178763-81c5-5656-9744-13c7ad1e595b"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Substance/actual-batch-substance-itermediate-1
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueString" : "Off-white solid"
}
},
// Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"fullUrl" : "urn:uuid:9c56948c-2a49-6609-2c01-4d197ea57a33",
"resource" : {
"resourceType" : "Observation",
"id" : "9c56948c-2a49-6609-2c01-4d197ea57a33",
"text" : // appearanceSubstance2
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"9c56948c-2a49-6609-2c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "9c56948c-2a49-6609-2c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_fc07b5d5-9fe1-92c2-2d06-57cb5b295e72\">See above (ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: Appearance <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Appearance)</span></p><p><b>subject</b>: <a href=\"#Substance_fc178764-81d5-5656-9744-13c7ad1e595b\">See above (Substance/fc178764-81d5-5656-9744-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: Off-white solid</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"
},
"status" : "final",
"code" : // ObservationDefinition/AppearanceSubstance
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Appearance",
"display" : "Appearance"
}
],
"text" : "Appearance"
},
"subject" : {
"reference" : "Substance/fc178764-81d5-5656-9744-13c7ad1e595b"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Substance/actual-batch-substance-itermediate-2
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueString" : "Off-white solid"
}
},
// Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"fullUrl" : "urn:uuid:9c56948c-2a39-6609-2c01-4d197eb57a33",
"resource" : {
"resourceType" : "Observation",
"id" : "9c56948c-2a39-6609-2c01-4d197eb57a33",
"text" : // appearanceSubstance3
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"9c56948c-2a39-6609-2c01-4d197eb57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "9c56948c-2a39-6609-2c01-4d197eb57a33" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_fc07b5d5-9fe1-92c2-2d06-57cb5b295e72\">See above (ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: Appearance <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Appearance)</span></p><p><b>subject</b>: <a href=\"#Substance_fc178764-81d6-5656-9744-13c7ad1e595b\">See above (Substance/fc178764-81d6-5656-9744-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: Off-white solid</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/fc07b5d5-9fe1-92c2-2d06-57cb5b295e72"
},
"status" : "final",
"code" : // ObservationDefinition/AppearanceSubstance
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Appearance",
"display" : "Appearance"
}
],
"text" : "Appearance"
},
"subject" : {
"reference" : "Substance/fc178764-81d6-5656-9744-13c7ad1e595b"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Substance/actual-batch-substance-itermediate-3
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueString" : "Off-white solid"
}
},
// Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"fullUrl" : "urn:uuid:9c56958c-2a39-6609-2c01-4d197ea57a33",
"resource" : {
"resourceType" : "Observation",
"id" : "9c56958c-2a39-6609-2c01-4d197ea57a33",
"text" : // identificationSubstance1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"9c56958c-2a39-6609-2c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "9c56958c-2a39-6609-2c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_3b1e878e-4bc9-8864-862f-e28b21233e8d\">See above (ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d)</a></p><p><b>status</b>: final</p><p><b>code</b>: ID by HPLC <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#IDT "Identification")</span></p><p><b>subject</b>: <a href=\"#Substance_fc178763-81c5-5656-9744-13c7ad1e595b\">See above (Substance/fc178763-81c5-5656-9744-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: Conforms</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d"
},
"status" : "final",
"code" : // ObservationDefinition/IdentificationSubstance
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "IDT",
"display" : "Identification"
}
],
"text" : "ID by HPLC"
},
"subject" : {
"reference" : "Substance/fc178763-81c5-5656-9744-13c7ad1e595b"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Substance/actual-batch-substance-itermediate-1
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueString" : "Conforms"
}
},
// Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"fullUrl" : "urn:uuid:9c56968c-2a49-6609-2c01-4d197ea57a33",
"resource" : {
"resourceType" : "Observation",
"id" : "9c56968c-2a49-6609-2c01-4d197ea57a33",
"text" : // identificationSubstance2
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"9c56968c-2a49-6609-2c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "9c56968c-2a49-6609-2c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_3b1e878e-4bc9-8864-862f-e28b21233e8d\">See above (ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d)</a></p><p><b>status</b>: final</p><p><b>code</b>: ID by HPLC <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#IDT "Identification")</span></p><p><b>subject</b>: <a href=\"#Substance_fc178764-81d5-5656-9744-13c7ad1e595b\">See above (Substance/fc178764-81d5-5656-9744-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: Conforms</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d"
},
"status" : "final",
"code" : // ObservationDefinition/IdentificationSubstance
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "IDT",
"display" : "Identification"
}
],
"text" : "ID by HPLC"
},
"subject" : {
"reference" : "Substance/fc178764-81d5-5656-9744-13c7ad1e595b"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Substance/actual-batch-substance-itermediate-2
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueString" : "Conforms"
}
},
// Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"fullUrl" : "urn:uuid:9c56978c-2a39-6609-2c01-4d197eb57a33",
"resource" : {
"resourceType" : "Observation",
"id" : "9c56978c-2a39-6609-2c01-4d197eb57a33",
"text" : // identificationSubstance3
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"9c56978c-2a39-6609-2c01-4d197eb57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "9c56978c-2a39-6609-2c01-4d197eb57a33" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_3b1e878e-4bc9-8864-862f-e28b21233e8d\">See above (ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d)</a></p><p><b>status</b>: final</p><p><b>code</b>: ID by HPLC <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#IDT "Identification")</span></p><p><b>subject</b>: <a href=\"#Substance_fc178764-81d6-5656-9744-13c7ad1e595b\">See above (Substance/fc178764-81d6-5656-9744-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: Does not conform</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/3b1e878e-4bc9-8864-862f-e28b21233e8d"
},
"status" : "final",
"code" : // ObservationDefinition/IdentificationSubstance
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "IDT",
"display" : "Identification"
}
],
"text" : "ID by HPLC"
},
"subject" : {
"reference" : "Substance/fc178764-81d6-5656-9744-13c7ad1e595b"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Substance/actual-batch-substance-itermediate-3
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueString" : "Does not conform"
}
},
// Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"fullUrl" : "urn:uuid:9c56948c-2a39-6609-1c01-4d197ea57a33",
"resource" : {
"resourceType" : "Observation",
"id" : "9c56948c-2a39-6609-1c01-4d197ea57a33",
"text" : // step1Yield1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"9c56948c-2a39-6609-1c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "9c56948c-2a39-6609-1c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_fd17b5d6-9fe1-91c2-2d06-47cb5b295e72\">See above (ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: <a href=\"#Substance_fc178763-81c5-5656-9744-13c7ad1e595b\">See above (Substance/fc178763-81c5-5656-9744-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 75 %</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"
},
"status" : "final",
"code" : // ObservationDefinition/Step1Yield
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Yield (%)",
"display" : "Yield (%)"
}
],
"text" : "Yield (%)"
},
"subject" : {
"reference" : "Substance/fc178763-81c5-5656-9744-13c7ad1e595b"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Substance/actual-batch-substance-itermediate-1
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 75,
"unit" : "%"
}
}
},
{
"fullUrl" : "urn:uuid:9c56948a-2b39-6609-1c01-4d197ea57a33",
"resource" : {
"resourceType" : "Observation",
"id" : "9c56948a-2b39-6609-1c01-4d197ea57a33",
"text" : // step1Yield2
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"9c56948a-2b39-6609-1c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "9c56948a-2b39-6609-1c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_fd17b5d6-9fe1-91c2-2d06-47cb5b295e72\">See above (ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: <a href=\"#Substance_fc178764-81d5-5656-9744-13c7ad1e595b\">See above (Substance/fc178764-81d5-5656-9744-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 77 %</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"
},
"status" : "final",
"code" : // ObservationDefinition/Step1Yield
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Yield (%)",
"display" : "Yield (%)"
}
],
"text" : "Yield (%)"
},
"subject" : {
"reference" : "Substance/fc178764-81d5-5656-9744-13c7ad1e595b"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Substance/actual-batch-substance-itermediate-2
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 77,
"unit" : "%"
}
}
},
{
"fullUrl" : "urn:uuid:9c56948a-2a39-6609-1c01-4d197ea57a33",
"resource" : {
"resourceType" : "Observation",
"id" : "9c56948a-2a39-6609-1c01-4d197ea57a33",
"text" : // step1Yield3
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"9c56948a-2a39-6609-1c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "9c56948a-2a39-6609-1c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_fd17b5d6-9fe1-91c2-2d06-47cb5b295e72\">See above (ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: <a href=\"#Substance_fc178764-81d6-5656-9744-13c7ad1e595b\">See above (Substance/fc178764-81d6-5656-9744-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 76 %</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/fd17b5d6-9fe1-91c2-2d06-47cb5b295e72"
},
"status" : "final",
"code" : // ObservationDefinition/Step1Yield
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Yield (%)",
"display" : "Yield (%)"
}
],
"text" : "Yield (%)"
},
"subject" : {
"reference" : "Substance/fc178764-81d6-5656-9744-13c7ad1e595b"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Substance/actual-batch-substance-itermediate-3
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 76,
"unit" : "%"
}
}
},
{
"fullUrl" : "urn:uuid:9c56948d-2a39-6609-1c01-4d197ea57a33",
"resource" : {
"resourceType" : "Observation",
"id" : "9c56948d-2a39-6609-1c01-4d197ea57a33",
"text" : // step2Yield1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"9c56948d-2a39-6609-1c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "9c56948d-2a39-6609-1c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_fd17b5d7-9fe1-91c2-2d06-47cb5b295e72\">See above (ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: <a href=\"#Substance_fc178763-81c5-5656-9754-13c7ad1e595b\">See above (Substance/fc178763-81c5-5656-9754-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 85 %</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"
},
"status" : "final",
"code" : // ObservationDefinition/Step2Yield
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Yield (%)",
"display" : "Yield (%)"
}
],
"text" : "Yield (%)"
},
"subject" : {
"reference" : "Substance/fc178763-81c5-5656-9754-13c7ad1e595b"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Substance/actual-batch-substance-itermediate-step2-1
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 85,
"unit" : "%"
}
}
},
{
"fullUrl" : "urn:uuid:9c56948c-2b39-6609-1c01-4d197ea57a33",
"resource" : {
"resourceType" : "Observation",
"id" : "9c56948c-2b39-6609-1c01-4d197ea57a33",
"text" : // step2Yield2
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"9c56948c-2b39-6609-1c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "9c56948c-2b39-6609-1c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_fd17b5d7-9fe1-91c2-2d06-47cb5b295e72\">See above (ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: <a href=\"#Substance_fc178764-81d5-5656-9764-13c7ad1e595b\">See above (Substance/fc178764-81d5-5656-9764-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 87 %</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"
},
"status" : "final",
"code" : // ObservationDefinition/Step2Yield
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Yield (%)",
"display" : "Yield (%)"
}
],
"text" : "Yield (%)"
},
"subject" : {
"reference" : "Substance/fc178764-81d5-5656-9764-13c7ad1e595b"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Substance/actual-batch-substance-itermediate-step2-2
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 87,
"unit" : "%"
}
}
},
{
"fullUrl" : "urn:uuid:9c56948b-2a39-6609-1c01-4d197ea57a33",
"resource" : {
"resourceType" : "Observation",
"id" : "9c56948b-2a39-6609-1c01-4d197ea57a33",
"text" : // step2Yield3
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"9c56948b-2a39-6609-1c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "9c56948b-2a39-6609-1c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_fd17b5d7-9fe1-91c2-2d06-47cb5b295e72\">See above (ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: Yield (%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#Yield (%))</span></p><p><b>subject</b>: <a href=\"#Substance_fc178764-81d6-6656-9744-13c7ad1e595b\">See above (Substance/fc178764-81d6-6656-9744-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 86 %</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/fd17b5d7-9fe1-91c2-2d06-47cb5b295e72"
},
"status" : "final",
"code" : // ObservationDefinition/Step2Yield
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "Yield (%)",
"display" : "Yield (%)"
}
],
"text" : "Yield (%)"
},
"subject" : {
"reference" : "Substance/fc178764-81d6-6656-9744-13c7ad1e595b"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Substance/actual-batch-substance-itermediate-step2-3
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 86,
"unit" : "%"
}
}
},
{
"fullUrl" : "urn:uuid:9c56958c-2a39-6609-1c01-4d197ea57a33",
"resource" : {
"resourceType" : "Observation",
"id" : "9c56958c-2a39-6609-1c01-4d197ea57a33",
"text" : // residualWaterContent1
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"9c56958c-2a39-6609-1c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "9c56958c-2a39-6609-1c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_fc27b5d6-9fe1-91c2-2d16-57cb5b295e72\">See above (ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: ResidualWaterContent (w/w%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#ResidualWaterContent "Residual Water Content (w/w%)")</span></p><p><b>subject</b>: <a href=\"#Substance_fc178763-81c5-5656-9744-13c7ad1e595b\">See above (Substance/fc178763-81c5-5656-9744-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 6.9 %</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"
},
"status" : "final",
"code" : // ObservationDefinition/ResidualWaterContent
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "ResidualWaterContent",
"display" : "Residual Water Content (w/w%)"
}
],
"text" : "ResidualWaterContent (w/w%)"
},
"subject" : {
"reference" : "Substance/fc178763-81c5-5656-9744-13c7ad1e595b"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Substance/actual-batch-substance-itermediate-1
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 6.9,
"unit" : "%"
}
}
},
{
"fullUrl" : "urn:uuid:9c56968a-2b39-6609-1c01-4d197ea57a33",
"resource" : {
"resourceType" : "Observation",
"id" : "9c56968a-2b39-6609-1c01-4d197ea57a33",
"text" : // residualWaterContent2
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"9c56968a-2b39-6609-1c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "9c56968a-2b39-6609-1c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_fc27b5d6-9fe1-91c2-2d16-57cb5b295e72\">See above (ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: ResidualWaterContent (w/w%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#ResidualWaterContent "Residual Water Content (w/w%)")</span></p><p><b>subject</b>: <a href=\"#Substance_fc178764-81d5-5656-9744-13c7ad1e595b\">See above (Substance/fc178764-81d5-5656-9744-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 7.0 %</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"
},
"status" : "final",
"code" : // ObservationDefinition/ResidualWaterContent
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "ResidualWaterContent",
"display" : "Residual Water Content (w/w%)"
}
],
"text" : "ResidualWaterContent (w/w%)"
},
"subject" : {
"reference" : "Substance/fc178764-81d5-5656-9744-13c7ad1e595b"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Substance/actual-batch-substance-itermediate-2
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 7.0,
"unit" : "%"
}
}
},
{
"fullUrl" : "urn:uuid:9c56978a-2a39-6609-1c01-4d197ea57a33",
"resource" : {
"resourceType" : "Observation",
"id" : "9c56978a-2a39-6609-1c01-4d197ea57a33",
"text" : // residualWaterContent3
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Observation</b><a name=\"9c56978a-2a39-6609-1c01-4d197ea57a33\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Observation "9c56978a-2a39-6609-1c01-4d197ea57a33" </p></div><p><b>instantiates</b>: <a href=\"#ObservationDefinition_fc27b5d6-9fe1-91c2-2d16-57cb5b295e72\">See above (ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72)</a></p><p><b>status</b>: final</p><p><b>code</b>: ResidualWaterContent (w/w%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-local-codes-drug-pq.html\">CodeSystem - Example Local Codes - Drug</a>#ResidualWaterContent "Residual Water Content (w/w%)")</span></p><p><b>subject</b>: <a href=\"#Substance_fc178764-81d6-5656-9744-13c7ad1e595b\">See above (Substance/fc178764-81d6-5656-9744-13c7ad1e595b)</a></p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: <a href=\"#Organization_378fbe5f-5926-3a5c-4c64-5428df877b08\">See above (Organization/378fbe5f-5926-3a5c-4c64-5428df877b08)</a></p><p><b>value</b>: 6.8 %</p></div>"
},
"instantiatesReference" : {
"reference" : "ObservationDefinition/fc27b5d6-9fe1-91c2-2d16-57cb5b295e72"
},
"status" : "final",
"code" : // ObservationDefinition/ResidualWaterContent
{
"coding" : [
{
"system" : "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq",
"code" : "ResidualWaterContent",
"display" : "Residual Water Content (w/w%)"
}
],
"text" : "ResidualWaterContent (w/w%)"
},
"subject" : {
"reference" : "Substance/fc178764-81d6-5656-9744-13c7ad1e595b"
},
"effectiveDateTime" : "2023-01-01T12:00:00Z",
"performer" : [
// Substance/actual-batch-substance-itermediate-3
{
"reference" : "Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"
}
],
"valueQuantity" : // Organization/378fbe5f-5926-3a5c-4c64-5428df877b08
{
"value" : 6.8,
"unit" : "%"
}
}
},
{
"fullUrl" : "urn:uuid:23dbbd32-2962-9fc3-40b1-67e864f21cd2",
"resource" : {
"resourceType" : "Organization",
"id" : "23dbbd32-2962-9fc3-40b1-67e864f21cd2",
"text" : // substance-manufacturer
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Organization</b><a name=\"23dbbd32-2962-9fc3-40b1-67e864f21cd2\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Organization "23dbbd32-2962-9fc3-40b1-67e864f21cd2" </p></div><p><b>identifier</b>: id:\u00a03003040516</p><p><b>name</b>: AAA Molybdenum Products, Inc.</p><h3>Contacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Address</b></td></tr><tr><td style=\"display: none\">*</td><td>7233 W 116th Pl Ste C Broomfield Colorado 80020 USA </td></tr></table></div>"
},
"identifier" : [
{
"system" : "urn:oid:2.16.840.1.113883.4.82",
"value" : "3003040516"
}
],
"name" : "AAA Molybdenum Products, Inc.",
"contact" : [
// FDA establishment identifier
{
"address" : {
"line" : [
"7233 W 116th Pl",
"Ste C"
],
"city" : "Broomfield",
"state" : "Colorado",
"postalCode" : "80020",
"country" : "USA"
}
}
]
}
},
{
"fullUrl" : "urn:uuid:378fbe5f-5926-3a5c-4c64-5428df877b08",
"resource" : {
"resourceType" : "Organization",
"id" : "378fbe5f-5926-3a5c-4c64-5428df877b08",
"text" : // testing lab
// 378fbe5f-5926-3a5c-4c64-5428df877b08
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Organization</b><a name=\"378fbe5f-5926-3a5c-4c64-5428df877b08\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Organization "378fbe5f-5926-3a5c-4c64-5428df877b08" </p></div><p><b>name</b>: Testing Lab</p></div>"
},
"name" : "Testing Lab"
}
},
{
"fullUrl" : "urn:uuid:57a9af63-315d-1585-a261-0e337b289390",
"resource" : {
"resourceType" : "SubstanceDefinition",
"id" : "57a9af63-315d-1585-a261-0e337b289390",
"meta" : // substancedefinition-component-substance-dxpq-ex1
{
"profile" : [
🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/SubstanceDefinition-component-substance-drug-pq"
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"57a9af63-315d-1585-a261-0e337b289390\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition "57a9af63-315d-1585-a261-0e337b289390" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-SubstanceDefinition-component-substance-drug-pq.html\">SubstanceDefinition - Component Substance Drug PQ</a></p></div><p><b>manufacturer</b>: <a href=\"#Organization_49d2f0c0-4b28-9271-8aaf-2996a8b9739c\">See above (Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c)</a></p><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>Stelbatolol</td></tr></table></div>"
},
"manufacturer" : [
{
"reference" : "Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"
}
],
"name" : [
// Organization/organization-dxpq-ex1
{
"name" : "Stelbatolol"
}
]
}
},
{
"fullUrl" : "urn:uuid:c458791f-7cb8-428e-83f7-8a205f821153",
"resource" : {
"resourceType" : "SubstanceDefinition",
"id" : "c458791f-7cb8-428e-83f7-8a205f821153",
"text" : // startingMaterial
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"c458791f-7cb8-428e-83f7-8a205f821153\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition "c458791f-7cb8-428e-83f7-8a205f821153" </p></div><p><b>manufacturer</b>: <a href=\"#Organization_23dbbd32-2962-9fc3-40b1-67e864f21cd2\">See above (Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2)</a></p><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>Stelbatosubstance</td></tr></table></div>"
},
"manufacturer" : [
{
"reference" : "Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2"
}
],
"name" : [
// Organization/substance-manufacturer
{
"name" : "Stelbatosubstance"
}
]
}
},
{
"fullUrl" : "urn:uuid:fc178762-81c5-5656-9744-13c7ad1e595b",
"resource" : {
"resourceType" : "Substance",
"id" : "fc178762-81c5-5656-9744-13c7ad1e595b",
"meta" : // actual-batch-substance-starting-1
{
"profile" : [
🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"
]
},
"text" : {
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Substance</b><a name=\"fc178762-81c5-5656-9744-13c7ad1e595b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance "fc178762-81c5-5656-9744-13c7ad1e595b" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Substance-drug-pq.html\">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-01</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 8.1 kg</p></blockquote><p><b>identifier</b>: id:\u00a0Start1Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#SubstanceDefinition_c458791f-7cb8-428e-83f7-8a205f821153\">See above (SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153)</a></td></tr></table></div>"
},
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
"extension" : [
{
"url" : "manufacturingDate",
"valueDateTime" : "2019-09-01"
},
{
"url" : "batchQuantity",
"valueQuantity" : {
"value" : 8.1,
"unit" : "kg"
}
}
]
}
],
"identifier" : [
{
"value" : "Start1Amgen"
}
],
"instance" : true,
"code" : {
"reference" : {
"reference" : "SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153"
}
}
}
},
// SubstanceDefinition/startingMaterial
{
"fullUrl" : "urn:uuid:fc178762-81d5-5656-9744-13c7ad1e595b",
"resource" : {
"resourceType" : "Substance",
"id" : "fc178762-81d5-5656-9744-13c7ad1e595b",
"meta" : // actual-batch-substance-starting-2
{
"profile" : [
🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"
]
},
"text" : {
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Substance</b><a name=\"fc178762-81d5-5656-9744-13c7ad1e595b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance "fc178762-81d5-5656-9744-13c7ad1e595b" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Substance-drug-pq.html\">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-01</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 8.2 kg</p></blockquote><p><b>identifier</b>: id:\u00a0Start2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#SubstanceDefinition_c458791f-7cb8-428e-83f7-8a205f821153\">See above (SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153)</a></td></tr></table></div>"
},
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
"extension" : [
{
"url" : "manufacturingDate",
"valueDateTime" : "2019-09-01"
},
{
"url" : "batchQuantity",
"valueQuantity" : {
"value" : 8.2,
"unit" : "kg"
}
}
]
}
],
"identifier" : [
{
"value" : "Start2Amgen"
}
],
"instance" : true,
"code" : {
"reference" : {
"reference" : "SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153"
}
}
}
},
// SubstanceDefinition/startingMaterial
{
"fullUrl" : "urn:uuid:fc178762-81d5-5656-9744-23c7ad1e595b",
"resource" : {
"resourceType" : "Substance",
"id" : "fc178762-81d5-5656-9744-23c7ad1e595b",
"meta" : // actual-batch-substance-starting-3
{
"profile" : [
🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"
]
},
"text" : {
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Substance</b><a name=\"fc178762-81d5-5656-9744-23c7ad1e595b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance "fc178762-81d5-5656-9744-23c7ad1e595b" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Substance-drug-pq.html\">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-01</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 8.3 kg</p></blockquote><p><b>identifier</b>: id:\u00a0Start3Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#SubstanceDefinition_c458791f-7cb8-428e-83f7-8a205f821153\">See above (SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153)</a></td></tr></table></div>"
},
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
"extension" : [
{
"url" : "manufacturingDate",
"valueDateTime" : "2019-09-01"
},
{
"url" : "batchQuantity",
"valueQuantity" : {
"value" : 8.3,
"unit" : "kg"
}
}
]
}
],
"identifier" : [
{
"value" : "Start3Amgen"
}
],
"instance" : true,
"code" : {
"reference" : {
"reference" : "SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821153"
}
}
}
},
// SubstanceDefinition/startingMaterial
{
"fullUrl" : "urn:uuid:c458791f-7cb8-428e-83f7-8a205f821154",
"resource" : {
"resourceType" : "SubstanceDefinition",
"id" : "c458791f-7cb8-428e-83f7-8a205f821154",
"text" : // resultingMaterial
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"c458791f-7cb8-428e-83f7-8a205f821154\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition "c458791f-7cb8-428e-83f7-8a205f821154" </p></div><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>Resultothane</td></tr></table></div>"
},
"name" : [
{
"name" : "Resultothane"
}
]
}
},
{
"fullUrl" : "urn:uuid:c458791f-7cb8-428e-83f7-8a205f821155",
"resource" : {
"resourceType" : "SubstanceDefinition",
"id" : "c458791f-7cb8-428e-83f7-8a205f821155",
"text" : // intermediateMaterial
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"c458791f-7cb8-428e-83f7-8a205f821155\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition "c458791f-7cb8-428e-83f7-8a205f821155" </p></div><p><b>manufacturer</b>: <a href=\"#Organization_23dbbd32-2962-9fc3-40b1-67e864f21cd2\">See above (Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2)</a></p><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>Processohol</td></tr></table></div>"
},
"manufacturer" : [
{
"reference" : "Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2"
}
],
"name" : [
// Organization/substance-manufacturer
{
"name" : "Processohol"
}
]
}
},
{
"fullUrl" : "urn:uuid:fc178763-81c5-5656-9744-13c7ad1e595b",
"resource" : {
"resourceType" : "Substance",
"id" : "fc178763-81c5-5656-9744-13c7ad1e595b",
"meta" : // actual-batch-substance-itermediate-1
{
"profile" : [
🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"
]
},
"text" : {
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Substance</b><a name=\"fc178763-81c5-5656-9744-13c7ad1e595b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance "fc178763-81c5-5656-9744-13c7ad1e595b" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Substance-drug-pq.html\">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 9.1 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: <a href=\"#Substance_fc178762-81c5-5656-9744-13c7ad1e595b\">See above (Substance/fc178762-81c5-5656-9744-13c7ad1e595b)</a></p><p><b>identifier</b>: id:\u00a0Intermed1Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#SubstanceDefinition_c458791f-7cb8-428e-83f7-8a205f821155\">See above (SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155)</a></td></tr></table></div>"
},
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
"extension" : [
{
"url" : "batchQuantity",
"valueQuantity" : {
"value" : 9.1,
"unit" : "kg"
}
}
]
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq",
"valueReference" : // assumes 1 to 1, could also be done via a Procedure but overkill
{
"reference" : "Substance/fc178762-81c5-5656-9744-13c7ad1e595b"
}
}
],
"identifier" : [
// Substance/actual-batch-substance-starting-1
// local extension
{
"value" : "Intermed1Amgen"
}
],
"instance" : true,
"code" : {
"reference" : {
"reference" : "SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155"
}
}
}
},
// SubstanceDefinition/intermediateMaterial
{
"fullUrl" : "urn:uuid:fc178764-81d5-5656-9744-13c7ad1e595b",
"resource" : {
"resourceType" : "Substance",
"id" : "fc178764-81d5-5656-9744-13c7ad1e595b",
"meta" : // actual-batch-substance-itermediate-2
{
"profile" : [
🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"
]
},
"text" : {
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Substance</b><a name=\"fc178764-81d5-5656-9744-13c7ad1e595b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance "fc178764-81d5-5656-9744-13c7ad1e595b" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Substance-drug-pq.html\">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 9.2 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: <a href=\"#Substance_fc178762-81d5-5656-9744-13c7ad1e595b\">See above (Substance/fc178762-81d5-5656-9744-13c7ad1e595b)</a></p><p><b>identifier</b>: id:\u00a0Intermed2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#SubstanceDefinition_c458791f-7cb8-428e-83f7-8a205f821155\">See above (SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155)</a></td></tr></table></div>"
},
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
"extension" : [
{
"url" : "batchQuantity",
"valueQuantity" : {
"value" : 9.2,
"unit" : "kg"
}
}
]
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq",
"valueReference" : // assumes 1 to 1, could also be done via a Procedure but overkill
{
"reference" : "Substance/fc178762-81d5-5656-9744-13c7ad1e595b"
}
}
],
"identifier" : [
// Substance/actual-batch-substance-starting-2
// local extension
{
"value" : "Intermed2Amgen"
}
],
"instance" : true,
"code" : {
"reference" : {
"reference" : "SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155"
}
}
}
},
// SubstanceDefinition/intermediateMaterial
{
"fullUrl" : "urn:uuid:fc178764-81d6-5656-9744-13c7ad1e595b",
"resource" : {
"resourceType" : "Substance",
"id" : "fc178764-81d6-5656-9744-13c7ad1e595b",
"meta" : // actual-batch-substance-itermediate-3
{
"profile" : [
🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"
]
},
"text" : {
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Substance</b><a name=\"fc178764-81d6-5656-9744-13c7ad1e595b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance "fc178764-81d6-5656-9744-13c7ad1e595b" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Substance-drug-pq.html\">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 9.3 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: <a href=\"#Substance_fc178762-81d5-5656-9744-23c7ad1e595b\">See above (Substance/fc178762-81d5-5656-9744-23c7ad1e595b)</a></p><p><b>identifier</b>: id:\u00a0Intermed3Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#SubstanceDefinition_c458791f-7cb8-428e-83f7-8a205f821155\">See above (SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155)</a></td></tr></table></div>"
},
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
"extension" : [
{
"url" : "batchQuantity",
"valueQuantity" : {
"value" : 9.3,
"unit" : "kg"
}
}
]
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq",
"valueReference" : // assumes 1 to 1, could also be done via a Procedure but overkill
{
"reference" : "Substance/fc178762-81d5-5656-9744-23c7ad1e595b"
}
}
],
"identifier" : [
// Substance/actual-batch-substance-starting-3
// local extension
{
"value" : "Intermed3Amgen"
}
],
"instance" : true,
"code" : {
"reference" : {
"reference" : "SubstanceDefinition/c458791f-7cb8-428e-83f7-8a205f821155"
}
}
}
},
// SubstanceDefinition/intermediateMaterial
{
"fullUrl" : "urn:uuid:c458791f-8cb8-428e-83f7-8a205f821153",
"resource" : {
"resourceType" : "SubstanceDefinition",
"id" : "c458791f-8cb8-428e-83f7-8a205f821153",
"text" : // startingMaterialStep2
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"c458791f-8cb8-428e-83f7-8a205f821153\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition "c458791f-8cb8-428e-83f7-8a205f821153" </p></div><p><b>manufacturer</b>: <a href=\"#Organization_23dbbd32-2962-9fc3-40b1-67e864f21cd2\">See above (Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2)</a></p><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>Stelbatosubstance2</td></tr></table></div>"
},
"manufacturer" : [
{
"reference" : "Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2"
}
],
"name" : [
// Organization/substance-manufacturer
{
"name" : "Stelbatosubstance2"
}
]
}
},
{
"fullUrl" : "urn:uuid:fc178762-81c5-5656-9744-13c7ad2e595b",
"resource" : {
"resourceType" : "Substance",
"id" : "fc178762-81c5-5656-9744-13c7ad2e595b",
"meta" : // actual-batch-substance-starting-step2-1
{
"profile" : [
🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"
]
},
"text" : {
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Substance</b><a name=\"fc178762-81c5-5656-9744-13c7ad2e595b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance "fc178762-81c5-5656-9744-13c7ad2e595b" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Substance-drug-pq.html\">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-02</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 7.1 kg</p></blockquote><p><b>identifier</b>: id:\u00a0Start1Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#SubstanceDefinition_c458791f-8cb8-428e-83f7-8a205f821153\">See above (SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153)</a></td></tr></table></div>"
},
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
"extension" : [
{
"url" : "manufacturingDate",
"valueDateTime" : "2019-09-02"
},
{
"url" : "batchQuantity",
"valueQuantity" : {
"value" : 7.1,
"unit" : "kg"
}
}
]
}
],
"identifier" : [
{
"value" : "Start1Step2Amgen"
}
],
"instance" : true,
"code" : {
"reference" : {
"reference" : "SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153"
}
}
}
},
// SubstanceDefinition/startingMaterialStep2
{
"fullUrl" : "urn:uuid:fc178762-81d5-5656-9744-13c7ad1e596b",
"resource" : {
"resourceType" : "Substance",
"id" : "fc178762-81d5-5656-9744-13c7ad1e596b",
"meta" : // actual-batch-substance-starting-step2-2
{
"profile" : [
🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"
]
},
"text" : {
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Substance</b><a name=\"fc178762-81d5-5656-9744-13c7ad1e596b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance "fc178762-81d5-5656-9744-13c7ad1e596b" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Substance-drug-pq.html\">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-02</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 7.2 kg</p></blockquote><p><b>identifier</b>: id:\u00a0Start2Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#SubstanceDefinition_c458791f-8cb8-428e-83f7-8a205f821153\">See above (SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153)</a></td></tr></table></div>"
},
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
"extension" : [
{
"url" : "manufacturingDate",
"valueDateTime" : "2019-09-02"
},
{
"url" : "batchQuantity",
"valueQuantity" : {
"value" : 7.2,
"unit" : "kg"
}
}
]
}
],
"identifier" : [
{
"value" : "Start2Step2Amgen"
}
],
"instance" : true,
"code" : {
"reference" : {
"reference" : "SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153"
}
}
}
},
// SubstanceDefinition/startingMaterialStep2
{
"fullUrl" : "urn:uuid:fc178762-81d5-5656-9744-23c7ad1e597b",
"resource" : {
"resourceType" : "Substance",
"id" : "fc178762-81d5-5656-9744-23c7ad1e597b",
"meta" : // actual-batch-substance-starting-step2-3
{
"profile" : [
🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"
]
},
"text" : {
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Substance</b><a name=\"fc178762-81d5-5656-9744-23c7ad1e597b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance "fc178762-81d5-5656-9744-23c7ad1e597b" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Substance-drug-pq.html\">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-02</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 7.3 kg</p></blockquote><p><b>identifier</b>: id:\u00a0Start3Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#SubstanceDefinition_c458791f-8cb8-428e-83f7-8a205f821153\">See above (SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153)</a></td></tr></table></div>"
},
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
"extension" : [
{
"url" : "manufacturingDate",
"valueDateTime" : "2019-09-02"
},
{
"url" : "batchQuantity",
"valueQuantity" : {
"value" : 7.3,
"unit" : "kg"
}
}
]
}
],
"identifier" : [
{
"value" : "Start3Step2Amgen"
}
],
"instance" : true,
"code" : {
"reference" : {
"reference" : "SubstanceDefinition/c458791f-8cb8-428e-83f7-8a205f821153"
}
}
}
},
// SubstanceDefinition/startingMaterialStep2
{
"fullUrl" : "urn:uuid:c458791f-7cb8-428e-84f7-8a205f821155",
"resource" : {
"resourceType" : "SubstanceDefinition",
"id" : "c458791f-7cb8-428e-84f7-8a205f821155",
"text" : // intermediateMaterialStep2
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"c458791f-7cb8-428e-84f7-8a205f821155\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition "c458791f-7cb8-428e-84f7-8a205f821155" </p></div><p><b>manufacturer</b>: <a href=\"#Organization_23dbbd32-2962-9fc3-40b1-67e864f21cd2\">See above (Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2)</a></p><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>ProcessoholStep2</td></tr></table></div>"
},
"manufacturer" : [
{
"reference" : "Organization/23dbbd32-2962-9fc3-40b1-67e864f21cd2"
}
],
"name" : [
// Organization/substance-manufacturer
{
"name" : "ProcessoholStep2"
}
]
}
},
{
"fullUrl" : "urn:uuid:fc178763-81c5-5656-9754-13c7ad1e595b",
"resource" : {
"resourceType" : "Substance",
"id" : "fc178763-81c5-5656-9754-13c7ad1e595b",
"meta" : // actual-batch-substance-itermediate-step2-1
{
"profile" : [
🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"
]
},
"text" : {
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Substance</b><a name=\"fc178763-81c5-5656-9754-13c7ad1e595b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance "fc178763-81c5-5656-9754-13c7ad1e595b" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Substance-drug-pq.html\">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 10.1 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: <a href=\"#Substance_fc178762-81c5-5656-9744-13c7ad2e595b\">See above (Substance/fc178762-81c5-5656-9744-13c7ad2e595b)</a></p><p><b>identifier</b>: id:\u00a0Intermed1Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#SubstanceDefinition_c458791f-7cb8-428e-84f7-8a205f821155\">See above (SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155)</a></td></tr></table></div>"
},
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
"extension" : [
{
"url" : "batchQuantity",
"valueQuantity" : {
"value" : 10.1,
"unit" : "kg"
}
}
]
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq",
"valueReference" : // assumes 1 to 1, could also be done via a Procedure but overkill
{
"reference" : "Substance/fc178762-81c5-5656-9744-13c7ad2e595b"
}
}
],
"identifier" : [
// Substance/actual-batch-substance-starting-step2-1
// local extension
{
"value" : "Intermed1Step2Amgen"
}
],
"instance" : true,
"code" : {
"reference" : {
"reference" : "SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155"
}
}
}
},
// SubstanceDefinition/intermediateMaterialStep2
{
"fullUrl" : "urn:uuid:fc178764-81d5-5656-9764-13c7ad1e595b",
"resource" : {
"resourceType" : "Substance",
"id" : "fc178764-81d5-5656-9764-13c7ad1e595b",
"meta" : // actual-batch-substance-itermediate-step2-2
{
"profile" : [
🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"
]
},
"text" : {
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Substance</b><a name=\"fc178764-81d5-5656-9764-13c7ad1e595b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance "fc178764-81d5-5656-9764-13c7ad1e595b" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Substance-drug-pq.html\">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 10.2 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: <a href=\"#Substance_fc178762-81d5-5656-9744-13c7ad1e596b\">See above (Substance/fc178762-81d5-5656-9744-13c7ad1e596b)</a></p><p><b>identifier</b>: id:\u00a0Intermed2Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#SubstanceDefinition_c458791f-7cb8-428e-84f7-8a205f821155\">See above (SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155)</a></td></tr></table></div>"
},
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
"extension" : [
{
"url" : "batchQuantity",
"valueQuantity" : {
"value" : 10.2,
"unit" : "kg"
}
}
]
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq",
"valueReference" : // assumes 1 to 1, could also be done via a Procedure but overkill
{
"reference" : "Substance/fc178762-81d5-5656-9744-13c7ad1e596b"
}
}
],
"identifier" : [
// Substance/actual-batch-substance-starting-step2-2
// local extension
{
"value" : "Intermed2Step2Amgen"
}
],
"instance" : true,
"code" : {
"reference" : {
"reference" : "SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155"
}
}
}
},
// SubstanceDefinition/intermediateMaterialStep2
{
"fullUrl" : "urn:uuid:fc178764-81d6-6656-9744-13c7ad1e595b",
"resource" : {
"resourceType" : "Substance",
"id" : "fc178764-81d6-6656-9744-13c7ad1e595b",
"meta" : // actual-batch-substance-itermediate-step2-3
{
"profile" : [
🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"
]
},
"text" : {
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Substance</b><a name=\"fc178764-81d6-6656-9744-13c7ad1e595b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance "fc178764-81d6-6656-9744-13c7ad1e595b" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Substance-drug-pq.html\">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 10.3 kg</p></blockquote><p><b>Extension - Batch Derived From PQ</b>: <a href=\"#Substance_fc178762-81d5-5656-9744-23c7ad1e597b\">See above (Substance/fc178762-81d5-5656-9744-23c7ad1e597b)</a></p><p><b>identifier</b>: id:\u00a0Intermed3Step2Amgen</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#SubstanceDefinition_c458791f-7cb8-428e-84f7-8a205f821155\">See above (SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155)</a></td></tr></table></div>"
},
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
"extension" : [
{
"url" : "batchQuantity",
"valueQuantity" : {
"value" : 10.3,
"unit" : "kg"
}
}
]
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-derived-from-pq",
"valueReference" : // assumes 1 to 1, could also be done via a Procedure but overkill
{
"reference" : "Substance/fc178762-81d5-5656-9744-23c7ad1e597b"
}
}
],
"identifier" : [
// Substance/actual-batch-substance-starting-step2-3
// local extension
{
"value" : "Intermed3Step2Amgen"
}
],
"instance" : true,
"code" : {
"reference" : {
"reference" : "SubstanceDefinition/c458791f-7cb8-428e-84f7-8a205f821155"
}
}
}
},
// SubstanceDefinition/intermediateMaterialStep2
{
"fullUrl" : "urn:uuid:c458791f-8cb8-428e-83f7-8a205f821154",
"resource" : {
"resourceType" : "SubstanceDefinition",
"id" : "c458791f-8cb8-428e-83f7-8a205f821154",
"text" : // resultingMaterialStep2
{
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"c458791f-8cb8-428e-83f7-8a205f821154\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition "c458791f-8cb8-428e-83f7-8a205f821154" </p></div><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>ResultothaneStep2</td></tr></table></div>"
},
"name" : [
{
"name" : "ResultothaneStep2"
}
]
}
},
{
"fullUrl" : "urn:uuid:49d2f0c0-4b28-9271-8aaf-2996a8b9739c",
"resource" : {
"resourceType" : "Organization",
"id" : "49d2f0c0-4b28-9271-8aaf-2996a8b9739c",
"meta" : // id value="substance-manufacturer"/
// organization-dxpq-ex1
{
"profile" : [
🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Organization-drug-pq"
]
},
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Organization</b><a name=\"49d2f0c0-4b28-9271-8aaf-2996a8b9739c\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Organization "49d2f0c0-4b28-9271-8aaf-2996a8b9739c" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Organization-drug-pq.html\">Organization - Drug PQ</a></p></div><p><b>identifier</b>: id:\u00a03003040516</p><p><b>name</b>: AAA Molybdenum Products, Inc.</p><h3>Contacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Address</b></td></tr><tr><td style=\"display: none\">*</td><td>7233 W 116th Pl Ste C Broomfield Colorado 80020 USA </td></tr></table></div>"
},
"identifier" : [
{
"system" : "urn:oid:2.16.840.1.113883.4.82",
"value" : "3003040516"
}
],
"name" : "AAA Molybdenum Products, Inc.",
"contact" : [
// FDA establishment identifier
{
"address" : {
"line" : [
"7233 W 116th Pl",
"Ste C"
],
"city" : "Broomfield",
"state" : "Colorado",
"postalCode" : "80020",
"country" : "USA"
}
}
]
}
},
{
"fullUrl" : "urn:uuid:fc078762-81c5-5656-9744-13c7ad1e595b",
"resource" : {
"resourceType" : "Substance",
"id" : "fc078762-81c5-5656-9744-13c7ad1e595b",
"meta" : // <id value="actual-batch-substance"/>
// substance-dxpq-ex1-unlinked
{
"profile" : [
🔗 "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Substance-drug-pq"
]
},
"text" : {
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Substance</b><a name=\"fc078762-81c5-5656-9744-13c7ad1e595b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance "fc078762-81c5-5656-9744-13c7ad1e595b" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Substance-drug-pq.html\">Substance - Drug PQ</a></p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-07</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 5.1 kg</p><blockquote><p><b>url</b></p><code>batchUtilization</code></blockquote><p><b>value</b>: Development <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.0.0/CodeSystem-v3-nciThesaurus.html\">NCI Thesaurus</a>#C133991)</span></p><blockquote><p><b>url</b></p><code>assignedManufacturer</code></blockquote><p><b>value</b>: <a href=\"#Organization_49d2f0c0-4b28-9271-8aaf-2996a8b9739c\">See above (Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c)</a></p></blockquote><p><b>Extension - Batch Release Date PQ</b>: 2019-09-08</p><p><b>Extension - Batch Retest Date PQ</b>: 2022-09-08</p><p><b>Extension - Actual Yield PQ</b>: 4.8 kg</p><p><b>identifier</b>: id:\u00a0SUB1Amgen, id:\u00a0SUB1SiteA</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#SubstanceDefinition_57a9af63-315d-1585-a261-0e337b289390\">See above (SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390)</a></td></tr></table></div>"
},
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
"extension" : [
{
"url" : "manufacturingDate",
"valueDateTime" : "2019-09-07"
},
{
"url" : "batchQuantity",
"valueQuantity" : {
"value" : 5.1,
"unit" : "kg"
}
},
{
"url" : "batchUtilization",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
"code" : "C133991",
"display" : "Development"
}
]
}
},
{
"url" : "assignedManufacturer",
"valueReference" : {
"reference" : "Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"
}
}
]
},
// Organization/organization-dxpq-ex1
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq",
"valueDateTime" : "2019-09-08"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-retest-date-pq",
"valueDateTime" : "2022-09-08"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq",
"valueQuantity" : {
"value" : 4.8,
"unit" : "kg"
}
}
],
"identifier" : [
// local extension
{
"value" : "SUB1Amgen"
},
{
"value" : "SUB1SiteA",
"assigner" : {
"reference" : "Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"
}
}
],
"instance" : true,
"code" : // Organization/organization-dxpq-ex1
{
"reference" : {
"reference" : "SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390"
}
}
}
},
// SubstanceDefinition/substancedefinition-component-substance-dxpq-ex1
{
"fullUrl" : "urn:uuid:cb31d747-2338-88d5-342c-8e9c097e4dad",
"resource" : {
"resourceType" : "Substance",
"id" : "cb31d747-2338-88d5-342c-8e9c097e4dad",
"text" : // actual-batch-substance-2-unlinked
{
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Substance</b><a name=\"cb31d747-2338-88d5-342c-8e9c097e4dad\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance "cb31d747-2338-88d5-342c-8e9c097e4dad" </p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-07</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 5.2 kg</p><blockquote><p><b>url</b></p><code>batchUtilization</code></blockquote><p><b>value</b>: Development <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.0.0/CodeSystem-v3-nciThesaurus.html\">NCI Thesaurus</a>#C133991)</span></p><blockquote><p><b>url</b></p><code>assignedManufacturer</code></blockquote><p><b>value</b>: <a href=\"#Organization_49d2f0c0-4b28-9271-8aaf-2996a8b9739c\">See above (Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c)</a></p></blockquote><p><b>Extension - Batch Release Date PQ</b>: 2019-09-08</p><p><b>Extension - Batch Retest Date PQ</b>: 2022-09-08</p><p><b>Extension - Actual Yield PQ</b>: 4.8 kg</p><p><b>identifier</b>: id:\u00a0SUB2Amgen, id:\u00a0SUB2SiteA</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#SubstanceDefinition_57a9af63-315d-1585-a261-0e337b289390\">See above (SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390)</a></td></tr></table></div>"
},
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
"extension" : [
{
"url" : "manufacturingDate",
"valueDateTime" : "2019-09-07"
},
{
"url" : "batchQuantity",
"valueQuantity" : {
"value" : 5.2,
"unit" : "kg"
}
},
{
"url" : "batchUtilization",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
"code" : "C133991",
"display" : "Development"
}
]
}
},
{
"url" : "assignedManufacturer",
"valueReference" : {
"reference" : "Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"
}
}
]
},
// Organization/organization-dxpq-ex1
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq",
"valueDateTime" : "2019-09-08"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-retest-date-pq",
"valueDateTime" : "2022-09-08"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq",
"valueQuantity" : {
"value" : 4.8,
"unit" : "kg"
}
}
],
"identifier" : [
// local extensions
{
"value" : "SUB2Amgen"
},
{
"value" : "SUB2SiteA",
"assigner" : {
"reference" : "Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"
}
}
],
"instance" : true,
"code" : // Organization/organization-dxpq-ex1
{
"reference" : {
"reference" : "SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390"
}
}
}
},
// SubstanceDefinition/substancedefinition-component-substance-dxpq-ex1
{
"fullUrl" : "urn:uuid:1551f97b-6f6d-825e-1fb3-44b0b090808c",
"resource" : {
"resourceType" : "Substance",
"id" : "1551f97b-6f6d-825e-1fb3-44b0b090808c",
"text" : // actual-batch-substance-3-unlinked
{
"status" : "extensions",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Substance</b><a name=\"1551f97b-6f6d-825e-1fb3-44b0b090808c\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Substance "1551f97b-6f6d-825e-1fb3-44b0b090808c" </p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2019-09-07</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 5.3 kg</p><blockquote><p><b>url</b></p><code>batchUtilization</code></blockquote><p><b>value</b>: Development <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.0.0/CodeSystem-v3-nciThesaurus.html\">NCI Thesaurus</a>#C133991)</span></p><blockquote><p><b>url</b></p><code>assignedManufacturer</code></blockquote><p><b>value</b>: <a href=\"#Organization_49d2f0c0-4b28-9271-8aaf-2996a8b9739c\">See above (Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c)</a></p></blockquote><p><b>Extension - Batch Release Date PQ</b>: 2019-09-08</p><p><b>Extension - Batch Retest Date PQ</b>: 2022-09-08</p><p><b>Extension - Actual Yield PQ</b>: 4.8 kg</p><p><b>identifier</b>: id:\u00a0SUB3Amgen, id:\u00a0SUB3SiteA</p><p><b>instance</b>: true</p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#SubstanceDefinition_57a9af63-315d-1585-a261-0e337b289390\">See above (SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390)</a></td></tr></table></div>"
},
"extension" : [
{
"url" : "http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch",
"extension" : [
{
"url" : "manufacturingDate",
"valueDateTime" : "2019-09-07"
},
{
"url" : "batchQuantity",
"valueQuantity" : {
"value" : 5.3,
"unit" : "kg"
}
},
{
"url" : "batchUtilization",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl",
"code" : "C133991",
"display" : "Development"
}
]
}
},
{
"url" : "assignedManufacturer",
"valueReference" : {
"reference" : "Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"
}
}
]
},
// Organization/organization-dxpq-ex1
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq",
"valueDateTime" : "2019-09-08"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-retest-date-pq",
"valueDateTime" : "2022-09-08"
},
{
"url" : "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq",
"valueQuantity" : {
"value" : 4.8,
"unit" : "kg"
}
}
],
"identifier" : [
// local extensions
{
"value" : "SUB3Amgen"
},
{
"value" : "SUB3SiteA",
"assigner" : {
"reference" : "Organization/49d2f0c0-4b28-9271-8aaf-2996a8b9739c"
}
}
],
"instance" : true,
"code" : // Organization/organization-dxpq-ex1
{
"reference" : {
"reference" : "SubstanceDefinition/57a9af63-315d-1585-a261-0e337b289390"
}
}
}
}
]
}
IG © HL7 International / Biomedical Research and Regulation. Package hl7.fhir.uv.pharm-quality#1.0.0-ballot based on FHIR 5.0.0. Generated 2023-12-18
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