Example: Bundle – Product Composition - TTL Representation - Pharmaceutical Quality (Industry) v1.0.0-ballot

This page is part of the Pharmaceutical Quality (Industry) (v1.0.0-ballot: STU1 Ballot 1) based on FHIR (HL7® FHIR® Standard) v5.0.0. . For a full list of available versions, see the Directory of published versions
: Example: Bundle – Product Composition - TTL Representation

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@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

 a fhir:Bundle ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "bundle-drug-product-composition-pq-ex1"] ; # 
  fhir:meta [
    ( fhir:profile [
fhir:v "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Bundle-drug-product-composition-pq"^^xsd:anyURI ;
fhir:link <http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Bundle-drug-product-composition-pq>     ] )
  ] ; # 
  fhir:type [ fhir:v "collection"] ; # 
  fhir:entry ( [
fhir:fullUrl [ fhir:v "urn:uuid:a0694a7a-aafa-4cbe-8135-c788a9a4d3d5"^^xsd:anyURI ] ;
    ( fhir:resource <urn:uuid:a0694a7a-aafa-4cbe-8135-c788a9a4d3d5> ) #  Section 1.1 - DP Identification 
  ] [
fhir:fullUrl [ fhir:v "urn:uuid:88a068e2-1d97-337b-3b9c-4b3f14bc3923"^^xsd:anyURI ] ;
    ( fhir:resource <urn:uuid:88a068e2-1d97-337b-3b9c-4b3f14bc3923> )
  ] [
fhir:fullUrl [ fhir:v "urn:uuid:b89ed9d2-80f9-0cfb-70a1-5a6572e73a65"^^xsd:anyURI ] ;
    ( fhir:resource <urn:uuid:b89ed9d2-80f9-0cfb-70a1-5a6572e73a65> )
  ] [
fhir:fullUrl [ fhir:v "urn:uuid:b89ed9d3-80f9-0cfb-70a1-5a6572e73a65"^^xsd:anyURI ] ;
    ( fhir:resource <urn:uuid:b89ed9d3-80f9-0cfb-70a1-5a6572e73a65> )
  ] [
fhir:fullUrl [ fhir:v "urn:uuid:b89ed9d2-80f9-0cfb-71a1-5a6572e73a65"^^xsd:anyURI ] ;
    ( fhir:resource <urn:uuid:b89ed9d2-80f9-0cfb-71a1-5a6572e73a65> )
  ] [
fhir:fullUrl [ fhir:v "urn:uuid:b89ed9d2-80f9-0cfb-70a1-5a6572e73a66"^^xsd:anyURI ] ;
    ( fhir:resource <urn:uuid:b89ed9d2-80f9-0cfb-70a1-5a6572e73a66> )
  ] [
fhir:fullUrl [ fhir:v "urn:uuid:b89ed9d3-80f9-0cfb-70a1-5a6572e73a66"^^xsd:anyURI ] ;
    ( fhir:resource <urn:uuid:b89ed9d3-80f9-0cfb-70a1-5a6572e73a66> )
  ] [
fhir:fullUrl [ fhir:v "urn:uuid:4cf2cbba-33e6-1124-9bf2-1c6756380474"^^xsd:anyURI ] ;
    ( fhir:resource <urn:uuid:4cf2cbba-33e6-1124-9bf2-1c6756380474> )
  ] [
fhir:fullUrl [ fhir:v "urn:uuid:4cf2cbba-33e6-1124-9bf2-1c6756380475"^^xsd:anyURI ] ;
    ( fhir:resource <urn:uuid:4cf2cbba-33e6-1124-9bf2-1c6756380475> )
  ] [
fhir:fullUrl [ fhir:v "urn:uuid:4cf2cbba-33e6-1124-9bf2-1c6756380476"^^xsd:anyURI ] ;
    ( fhir:resource <urn:uuid:4cf2cbba-33e6-1124-9bf2-1c6756380476> )
  ] [
fhir:fullUrl [ fhir:v "urn:uuid:4cf2cbba-33e6-1124-9bf2-1c6756380477"^^xsd:anyURI ] ;
    ( fhir:resource <urn:uuid:4cf2cbba-33e6-1124-9bf2-1c6756380477> )
  ] [
fhir:fullUrl [ fhir:v "urn:uuid:4cf2cbba-33e6-1124-9bf2-1c6756380478"^^xsd:anyURI ] ;
    ( fhir:resource <urn:uuid:4cf2cbba-33e6-1124-9bf2-1c6756380478> )
  ] ) . #  MedicinalProductDefinition - the main resource in any product scenario 

<urn:uuid:a0694a7a-aafa-4cbe-8135-c788a9a4d3d5> a fhir:MedicinalProductDefinition ;
  fhir:id [ fhir:v "a0694a7a-aafa-4cbe-8135-c788a9a4d3d5"] ; # medicinalproductdefinition-drug-product-dxpq-ex1
  fhir:text [
fhir:status [ fhir:v "generated" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: MedicinalProductDefinition</b><a name=\"a0694a7a-aafa-4cbe-8135-c788a9a4d3d5\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource MedicinalProductDefinition &quot;a0694a7a-aafa-4cbe-8135-c788a9a4d3d5&quot; </p></div><p><b>description</b>: Stelbatalol is formulated as an immediate-release, oral, solid dosage form in strengths of 20 mg of the free base equivalent. The 20 mg strength is presented as an orange, round, film coated tablet, debossed with '175' on one side.</p><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>ProductName</b></td><td><b>Type</b></td></tr><tr><td style=\"display: none\">*</td><td>Stalbatolol</td><td>Proprietary <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-productNameType-local-pq.html\">CodeSystem - Product Name Type</a>#Proprietary)</span></td></tr></table></div>"
  ] ; # 
  fhir:description [ fhir:v "Stelbatalol is formulated as an immediate-release, oral, solid dosage form in strengths of 20 mg of the free base equivalent. The 20 mg strength is presented as an orange, round, film coated tablet, debossed with '175' on one side."] ; # 
  fhir:name ( [
fhir:productName [ fhir:v "Stalbatolol" ] ;
fhir:type [
      ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-productNameType-local-pq"^^xsd:anyURI ] ;
fhir:code [ fhir:v "Proprietary" ] ;
fhir:display [ fhir:v "Proprietary" ]       ] )     ]
  ] ) . # 

<urn:uuid:88a068e2-1d97-337b-3b9c-4b3f14bc3923> a fhir:PackagedProductDefinition ;
  fhir:id [ fhir:v "88a068e2-1d97-337b-3b9c-4b3f14bc3923"] ; # packagedproductdefinition-dxpq-ex1
  fhir:meta [
    ( fhir:profile [
fhir:v "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/PackagedProductDefinition-drug-pq"^^xsd:anyURI ;
fhir:link <http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/PackagedProductDefinition-drug-pq>     ] )
  ] ; # 
  fhir:text [
fhir:status [ fhir:v "generated" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: PackagedProductDefinition</b><a name=\"88a068e2-1d97-337b-3b9c-4b3f14bc3923\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource PackagedProductDefinition &quot;88a068e2-1d97-337b-3b9c-4b3f14bc3923&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-PackagedProductDefinition-drug-pq.html\">PackagedProductDefinition - Drug PQ</a></p></div><p><b>packageFor</b>: <a href=\"#MedicinalProductDefinition_a0694a7a-aafa-4cbe-8135-c788a9a4d3d5\">See above (MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5)</a></p><p><b>description</b>: The commercial primary pack is a high-density polyethylene (HDPE) bottle with a child-resistant polypropylene (PP) screw cap.  Inside the bottle is a desiccant, containing silica gel. Induction seal membranes provide additional tamper evidence. For further details of the packaging components, see ‘P.7 Container Closure System for Drug Product’. </p></div>"
  ] ; # 
  fhir:packageFor ( [
fhir:reference [ fhir:v "MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5" ] # MedicinalProductDefinition\/medicinalproductdefinition-drug-product-dxpq-ex1
  ] ) ; # 
  fhir:description [ fhir:v "The commercial primary pack is a high-density polyethylene (HDPE) bottle with a child-resistant polypropylene (PP) screw cap.  Inside the bottle is a desiccant, containing silica gel. Induction seal membranes provide additional tamper evidence. For further details of the packaging components, see ‘P.7 Container Closure System for Drug Product’. "] . # 

<urn:uuid:b89ed9d2-80f9-0cfb-70a1-5a6572e73a65> a fhir:Ingredient ;
  fhir:id [ fhir:v "b89ed9d2-80f9-0cfb-70a1-5a6572e73a65"] ; # ingredient1
  fhir:text [
fhir:status [ fhir:v "generated" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Ingredient</b><a name=\"b89ed9d2-80f9-0cfb-70a1-5a6572e73a65\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Ingredient &quot;b89ed9d2-80f9-0cfb-70a1-5a6572e73a65&quot; </p></div><p><b>status</b>: active</p><p><b>for</b>: <a href=\"#MedicinalProductDefinition_a0694a7a-aafa-4cbe-8135-c788a9a4d3d5\">See above (MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5)</a></p><p><b>role</b>: Active <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-ingredient-role.html\">Ingredient Role</a>#100000072072)</span></p><blockquote><p><b>substance</b></p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#SubstanceDefinition_4cf2cbba-33e6-1124-9bf2-1c6756380474\">See above (SubstanceDefinition/4cf2cbba-33e6-1124-9bf2-1c6756380474: Stelbatolol)</a></td></tr></table><blockquote><p><b>strength</b></p><p><b>presentation</b>: 15.2 mg/1 tablet</p></blockquote><blockquote><p><b>strength</b></p><p><b>concentration</b>: 97.9 % w/w</p></blockquote></blockquote></div>"
  ] ; # 
  fhir:status [ fhir:v "active"] ; # 
  fhir:for ( [
fhir:reference [ fhir:v "MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5" ] # MedicinalProductDefinition\/medicinalproductdefinition-drug-product-dxpq-ex1
  ] ) ; # 
  fhir:role [
    ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/ingredient-role"^^xsd:anyURI ] ;
fhir:code [ fhir:v "100000072072" ] ;
fhir:display [ fhir:v "Active" ]     ] )
  ] ; # 
  fhir:substance [
fhir:code [
fhir:reference [
fhir:reference [ fhir:v "SubstanceDefinition/4cf2cbba-33e6-1124-9bf2-1c6756380474" ] ; # SubstanceDefinition\/substance1
fhir:display [ fhir:v "Stelbatolol" ]       ]     ] ;
    ( fhir:strength [
fhir:presentation [
a fhir:Ratio ;
fhir:numerator [
fhir:value [ fhir:v "15.2"^^xsd:decimal ] ;
fhir:unit [ fhir:v "mg" ]         ] ; #  todo add ucum 
fhir:denominator [
fhir:value [ fhir:v "1"^^xsd:decimal ] ;
fhir:unit [ fhir:v "tablet" ]         ]       ]     ] [
fhir:concentration [
a fhir:Quantity ;
fhir:value [ fhir:v "97.9"^^xsd:decimal ] ;
fhir:unit [ fhir:v "% w/w" ]       ]     ] )
  ] . # 

<urn:uuid:b89ed9d3-80f9-0cfb-70a1-5a6572e73a65> a fhir:Ingredient ;
  fhir:id [ fhir:v "b89ed9d3-80f9-0cfb-70a1-5a6572e73a65"] ; # excipient1
  fhir:text [
fhir:status [ fhir:v "generated" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Ingredient</b><a name=\"b89ed9d3-80f9-0cfb-70a1-5a6572e73a65\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Ingredient &quot;b89ed9d3-80f9-0cfb-70a1-5a6572e73a65&quot; </p></div><p><b>status</b>: active</p><p><b>for</b>: <a href=\"#MedicinalProductDefinition_a0694a7a-aafa-4cbe-8135-c788a9a4d3d5\">See above (MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5)</a></p><p><b>role</b>: Excipient <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-ingredient-role.html\">Ingredient Role</a>#100000072082)</span></p><p><b>function</b>: Diluent <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-ingredientFunction-local-pq.html\">CodeSystem - Ingredient Function</a>#diluent)</span></p><blockquote><p><b>substance</b></p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#SubstanceDefinition_4cf2cbba-33e6-1124-9bf2-1c6756380475\">See above (SubstanceDefinition/4cf2cbba-33e6-1124-9bf2-1c6756380475: Mannitol)</a></td></tr></table><blockquote><p><b>strength</b></p><p><b>presentation</b>: 145.0 mg/1 tablet</p></blockquote><blockquote><p><b>strength</b></p><p><b>concentration</b>: 1 % w/w</p></blockquote></blockquote></div>"
  ] ; # 
  fhir:status [ fhir:v "active"] ; # 
  fhir:for ( [
fhir:reference [ fhir:v "MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5" ] # MedicinalProductDefinition\/medicinalproductdefinition-drug-product-dxpq-ex1
  ] ) ; # 
  fhir:role [
    ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/ingredient-role"^^xsd:anyURI ] ;
fhir:code [ fhir:v "100000072082" ] ;
fhir:display [ fhir:v "Excipient" ]     ] )
  ] ; # 
  fhir:function ( [
    ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-ingredientFunction-local-pq"^^xsd:anyURI ] ;
fhir:code [ fhir:v "diluent" ] ;
fhir:display [ fhir:v "Diluent" ]     ] )
  ] ) ; # 
  fhir:substance [
fhir:code [
fhir:reference [
fhir:reference [ fhir:v "SubstanceDefinition/4cf2cbba-33e6-1124-9bf2-1c6756380475" ] ; # SubstanceDefinition\/sd-excipient1
fhir:display [ fhir:v "Mannitol" ]       ]     ] ;
    ( fhir:strength [
fhir:presentation [
a fhir:Ratio ;
fhir:numerator [
fhir:value [ fhir:v "145.0"^^xsd:decimal ] ;
fhir:unit [ fhir:v "mg" ]         ] ;
fhir:denominator [
fhir:value [ fhir:v "1"^^xsd:decimal ] ;
fhir:unit [ fhir:v "tablet" ]         ]       ]     ] [
fhir:concentration [
a fhir:Quantity ;
fhir:value [ fhir:v "1"^^xsd:decimal ] ;
fhir:unit [ fhir:v "% w/w" ]       ]     ] )
  ] . # 

<urn:uuid:b89ed9d2-80f9-0cfb-71a1-5a6572e73a65> a fhir:Ingredient ;
  fhir:id [ fhir:v "b89ed9d2-80f9-0cfb-71a1-5a6572e73a65"] ; # excipient2
  fhir:text [
fhir:status [ fhir:v "generated" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Ingredient</b><a name=\"b89ed9d2-80f9-0cfb-71a1-5a6572e73a65\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Ingredient &quot;b89ed9d2-80f9-0cfb-71a1-5a6572e73a65&quot; </p></div><p><b>status</b>: active</p><p><b>for</b>: <a href=\"#MedicinalProductDefinition_a0694a7a-aafa-4cbe-8135-c788a9a4d3d5\">See above (MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5)</a></p><p><b>role</b>: Excipient <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-ingredient-role.html\">Ingredient Role</a>#100000072082)</span></p><p><b>function</b>: Disintegrant <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-ingredientFunction-local-pq.html\">CodeSystem - Ingredient Function</a>#disintegrant)</span></p><blockquote><p><b>substance</b></p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#SubstanceDefinition_4cf2cbba-33e6-1124-9bf2-1c6756380476\">See above (SubstanceDefinition/4cf2cbba-33e6-1124-9bf2-1c6756380476: Maize starch)</a></td></tr></table><blockquote><p><b>strength</b></p><p><b>presentation</b>: 13.8 mg/1 tablet</p></blockquote><blockquote><p><b>strength</b></p><p><b>concentration</b>: 0.5 % w/w</p></blockquote></blockquote></div>"
  ] ; # 
  fhir:status [ fhir:v "active"] ; # 
  fhir:for ( [
fhir:reference [ fhir:v "MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5" ] # MedicinalProductDefinition\/medicinalproductdefinition-drug-product-dxpq-ex1
  ] ) ; # 
  fhir:role [
    ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/ingredient-role"^^xsd:anyURI ] ;
fhir:code [ fhir:v "100000072082" ] ;
fhir:display [ fhir:v "Excipient" ]     ] )
  ] ; # 
  fhir:function ( [
    ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-ingredientFunction-local-pq"^^xsd:anyURI ] ;
fhir:code [ fhir:v "disintegrant" ] ;
fhir:display [ fhir:v "Disintegrant" ]     ] )
  ] ) ; # 
  fhir:substance [
fhir:code [
fhir:reference [
fhir:reference [ fhir:v "SubstanceDefinition/4cf2cbba-33e6-1124-9bf2-1c6756380476" ] ; # SubstanceDefinition\/sd-excipient2
fhir:display [ fhir:v "Maize starch" ]       ]     ] ;
    ( fhir:strength [
fhir:presentation [
a fhir:Ratio ;
fhir:numerator [
fhir:value [ fhir:v "13.8"^^xsd:decimal ] ;
fhir:unit [ fhir:v "mg" ]         ] ;
fhir:denominator [
fhir:value [ fhir:v "1"^^xsd:decimal ] ;
fhir:unit [ fhir:v "tablet" ]         ]       ]     ] [
fhir:concentration [
a fhir:Quantity ;
fhir:value [ fhir:v "0.5"^^xsd:decimal ] ;
fhir:unit [ fhir:v "% w/w" ]       ]     ] )
  ] . # 

<urn:uuid:b89ed9d2-80f9-0cfb-70a1-5a6572e73a66> a fhir:Ingredient ;
  fhir:id [ fhir:v "b89ed9d2-80f9-0cfb-70a1-5a6572e73a66"] ; # excipient3
  fhir:text [
fhir:status [ fhir:v "generated" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Ingredient</b><a name=\"b89ed9d2-80f9-0cfb-70a1-5a6572e73a66\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Ingredient &quot;b89ed9d2-80f9-0cfb-70a1-5a6572e73a66&quot; </p></div><p><b>status</b>: active</p><p><b>for</b>: <a href=\"#MedicinalProductDefinition_a0694a7a-aafa-4cbe-8135-c788a9a4d3d5\">See above (MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5)</a></p><p><b>role</b>: Excipient <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-ingredient-role.html\">Ingredient Role</a>#100000072082)</span></p><p><b>function</b>: Disintegrant <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-ingredientFunction-local-pq.html\">CodeSystem - Ingredient Function</a>#disintegrant)</span></p><blockquote><p><b>substance</b></p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#SubstanceDefinition_4cf2cbba-33e6-1124-9bf2-1c6756380477\">See above (SubstanceDefinition/4cf2cbba-33e6-1124-9bf2-1c6756380477: Calcium carboxymethylcellulose)</a></td></tr></table><blockquote><p><b>strength</b></p><p><b>presentation</b>: 4.0 mg/1 tablet</p></blockquote><blockquote><p><b>strength</b></p><p><b>concentration</b>: 0.25 % w/w</p></blockquote></blockquote></div>"
  ] ; # 
  fhir:status [ fhir:v "active"] ; # 
  fhir:for ( [
fhir:reference [ fhir:v "MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5" ] # MedicinalProductDefinition\/medicinalproductdefinition-drug-product-dxpq-ex1
  ] ) ; # 
  fhir:role [
    ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/ingredient-role"^^xsd:anyURI ] ;
fhir:code [ fhir:v "100000072082" ] ;
fhir:display [ fhir:v "Excipient" ]     ] )
  ] ; # 
  fhir:function ( [
    ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-ingredientFunction-local-pq"^^xsd:anyURI ] ;
fhir:code [ fhir:v "disintegrant" ] ;
fhir:display [ fhir:v "Disintegrant" ]     ] )
  ] ) ; # 
  fhir:substance [
fhir:code [
fhir:reference [
fhir:reference [ fhir:v "SubstanceDefinition/4cf2cbba-33e6-1124-9bf2-1c6756380477" ] ; # SubstanceDefinition\/sd-excipient3
fhir:display [ fhir:v "Calcium carboxymethylcellulose" ]       ]     ] ;
    ( fhir:strength [
fhir:presentation [
a fhir:Ratio ;
fhir:numerator [
fhir:value [ fhir:v "4.0"^^xsd:decimal ] ;
fhir:unit [ fhir:v "mg" ]         ] ;
fhir:denominator [
fhir:value [ fhir:v "1"^^xsd:decimal ] ;
fhir:unit [ fhir:v "tablet" ]         ]       ]     ] [
fhir:concentration [
a fhir:Quantity ;
fhir:value [ fhir:v "0.25"^^xsd:decimal ] ;
fhir:unit [ fhir:v "% w/w" ]       ]     ] )
  ] . # 

<urn:uuid:b89ed9d3-80f9-0cfb-70a1-5a6572e73a66> a fhir:Ingredient ;
  fhir:id [ fhir:v "b89ed9d3-80f9-0cfb-70a1-5a6572e73a66"] ; # excipient4
  fhir:text [
fhir:status [ fhir:v "generated" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Ingredient</b><a name=\"b89ed9d3-80f9-0cfb-70a1-5a6572e73a66\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Ingredient &quot;b89ed9d3-80f9-0cfb-70a1-5a6572e73a66&quot; </p></div><p><b>status</b>: active</p><p><b>for</b>: <a href=\"#MedicinalProductDefinition_a0694a7a-aafa-4cbe-8135-c788a9a4d3d5\">See above (MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5)</a></p><p><b>role</b>: Excipient <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-ingredient-role.html\">Ingredient Role</a>#100000072082)</span></p><p><b>function</b>: Lubricant <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-ingredientFunction-local-pq.html\">CodeSystem - Ingredient Function</a>#lubricant)</span></p><blockquote><p><b>substance</b></p><h3>Codes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"#SubstanceDefinition_4cf2cbba-33e6-1124-9bf2-1c6756380478\">See above (SubstanceDefinition/4cf2cbba-33e6-1124-9bf2-1c6756380478: Magnesium stearate)</a></td></tr></table><blockquote><p><b>strength</b></p><p><b>presentation</b>: 2.0 mg/1 tablet</p></blockquote><blockquote><p><b>strength</b></p><p><b>concentration</b>: 0.35 % w/w</p></blockquote></blockquote></div>"
  ] ; # 
  fhir:status [ fhir:v "active"] ; # 
  fhir:for ( [
fhir:reference [ fhir:v "MedicinalProductDefinition/a0694a7a-aafa-4cbe-8135-c788a9a4d3d5" ] # MedicinalProductDefinition\/medicinalproductdefinition-drug-product-dxpq-ex1
  ] ) ; # 
  fhir:role [
    ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/ingredient-role"^^xsd:anyURI ] ;
fhir:code [ fhir:v "100000072082" ] ;
fhir:display [ fhir:v "Excipient" ]     ] )
  ] ; # 
  fhir:function ( [
    ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-ingredientFunction-local-pq"^^xsd:anyURI ] ;
fhir:code [ fhir:v "lubricant" ] ;
fhir:display [ fhir:v "Lubricant" ]     ] )
  ] ) ; # 
  fhir:substance [
fhir:code [
fhir:reference [
fhir:reference [ fhir:v "SubstanceDefinition/4cf2cbba-33e6-1124-9bf2-1c6756380478" ] ; # SubstanceDefinition\/sd-excipient4
fhir:display [ fhir:v "Magnesium stearate" ]       ]     ] ;
    ( fhir:strength [
fhir:presentation [
a fhir:Ratio ;
fhir:numerator [
fhir:value [ fhir:v "2.0"^^xsd:decimal ] ;
fhir:unit [ fhir:v "mg" ]         ] ;
fhir:denominator [
fhir:value [ fhir:v "1"^^xsd:decimal ] ;
fhir:unit [ fhir:v "tablet" ]         ]       ]     ] [
fhir:concentration [
a fhir:Quantity ;
fhir:value [ fhir:v "0.35"^^xsd:decimal ] ;
fhir:unit [ fhir:v "% w/w" ]       ]     ] )
  ] . # 

<urn:uuid:4cf2cbba-33e6-1124-9bf2-1c6756380474> a fhir:SubstanceDefinition ;
  fhir:id [ fhir:v "4cf2cbba-33e6-1124-9bf2-1c6756380474"] ; # substance1
  fhir:text [
fhir:status [ fhir:v "generated" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"4cf2cbba-33e6-1124-9bf2-1c6756380474\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition &quot;4cf2cbba-33e6-1124-9bf2-1c6756380474&quot; </p></div><p><b>grade</b>: In-house <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-grade-local-pq.html\">CodeSystem - Grade</a>#in-house)</span></p><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>Stelbatolol</td></tr></table></div>"
  ] ; # 
  fhir:grade ( [
    ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-grade-local-pq"^^xsd:anyURI ] ;
fhir:code [ fhir:v "in-house" ] ;
fhir:display [ fhir:v "In-house" ]     ] )
  ] ) ; # 
  fhir:name ( [
fhir:name [ fhir:v "Stelbatolol" ]
  ] ) . # 

<urn:uuid:4cf2cbba-33e6-1124-9bf2-1c6756380475> a fhir:SubstanceDefinition ;
  fhir:id [ fhir:v "4cf2cbba-33e6-1124-9bf2-1c6756380475"] ; # sd-excipient1
  fhir:text [
fhir:status [ fhir:v "generated" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"4cf2cbba-33e6-1124-9bf2-1c6756380475\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition &quot;4cf2cbba-33e6-1124-9bf2-1c6756380475&quot; </p></div><p><b>grade</b>: NF / Ph Eur <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-grade-local-pq.html\">CodeSystem - Grade</a>#NF-PH-Eur)</span></p><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>Mannitol</td></tr></table></div>"
  ] ; # 
  fhir:grade ( [
    ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-grade-local-pq"^^xsd:anyURI ] ;
fhir:code [ fhir:v "NF-PH-Eur" ] ;
fhir:display [ fhir:v "NF / Ph Eur" ]     ] )
  ] ) ; # 
  fhir:name ( [
fhir:name [ fhir:v "Mannitol" ]
  ] ) . # 

<urn:uuid:4cf2cbba-33e6-1124-9bf2-1c6756380476> a fhir:SubstanceDefinition ;
  fhir:id [ fhir:v "4cf2cbba-33e6-1124-9bf2-1c6756380476"] ; # sd-excipient2
  fhir:text [
fhir:status [ fhir:v "generated" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"4cf2cbba-33e6-1124-9bf2-1c6756380476\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition &quot;4cf2cbba-33e6-1124-9bf2-1c6756380476&quot; </p></div><p><b>grade</b>: NF / Ph Eur <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-grade-local-pq.html\">CodeSystem - Grade</a>#NF-PH-Eur)</span></p><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>Maize starch</td></tr></table></div>"
  ] ; # 
  fhir:grade ( [
    ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-grade-local-pq"^^xsd:anyURI ] ;
fhir:code [ fhir:v "NF-PH-Eur" ] ;
fhir:display [ fhir:v "NF / Ph Eur" ]     ] )
  ] ) ; # 
  fhir:name ( [
fhir:name [ fhir:v "Maize starch" ]
  ] ) . # 

<urn:uuid:4cf2cbba-33e6-1124-9bf2-1c6756380477> a fhir:SubstanceDefinition ;
  fhir:id [ fhir:v "4cf2cbba-33e6-1124-9bf2-1c6756380477"] ; # sd-excipient3
  fhir:text [
fhir:status [ fhir:v "generated" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"4cf2cbba-33e6-1124-9bf2-1c6756380477\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition &quot;4cf2cbba-33e6-1124-9bf2-1c6756380477&quot; </p></div><p><b>grade</b>: NF / Ph Eur <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-grade-local-pq.html\">CodeSystem - Grade</a>#NF-PH-Eur)</span></p><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>Calcium carboxymethylcellulose</td></tr></table></div>"
  ] ; # 
  fhir:grade ( [
    ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-grade-local-pq"^^xsd:anyURI ] ;
fhir:code [ fhir:v "NF-PH-Eur" ] ;
fhir:display [ fhir:v "NF / Ph Eur" ]     ] )
  ] ) ; # 
  fhir:name ( [
fhir:name [ fhir:v "Calcium carboxymethylcellulose" ]
  ] ) . # 

<urn:uuid:4cf2cbba-33e6-1124-9bf2-1c6756380478> a fhir:SubstanceDefinition ;
  fhir:id [ fhir:v "4cf2cbba-33e6-1124-9bf2-1c6756380478"] ; # sd-excipient4
  fhir:text [
fhir:status [ fhir:v "generated" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"4cf2cbba-33e6-1124-9bf2-1c6756380478\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition &quot;4cf2cbba-33e6-1124-9bf2-1c6756380478&quot; </p></div><p><b>grade</b>: NF / Ph Eur <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-grade-local-pq.html\">CodeSystem - Grade</a>#NF-PH-Eur)</span></p><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>Magnesium stearate</td></tr></table></div>"
  ] ; # 
  fhir:grade ( [
    ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-grade-local-pq"^^xsd:anyURI ] ;
fhir:code [ fhir:v "NF-PH-Eur" ] ;
fhir:display [ fhir:v "NF / Ph Eur" ]     ] )
  ] ) ; # 
  fhir:name ( [
fhir:name [ fhir:v "Magnesium stearate" ]
  ] ) . #