Pharmaceutical Quality (Industry)
1.0.0 - STU1
Pharmaceutical Quality (Industry)
1.0.0 - STU1
This page is part of the Pharmaceutical Quality (Industry) (v1.0.0: STU1) based on FHIR (HL7® FHIR® Standard) v5.0.0. This is the current published version. For a full list of available versions, see the Directory of published versions
@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
# - resource -------------------------------------------------------------------
# Substance General Properties
a fhir:Bundle ;
fhir:nodeRole fhir:treeRoot ;
fhir:id [ fhir:v "bundle-drug-substance-general-properties-pq-ex1"] ; #
fhir:meta [
( fhir:profile [
fhir:v "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Bundle-drug-substance-general-properties-pq"^^xsd:anyURI ;
fhir:link <http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Bundle-drug-substance-general-properties-pq> ] )
] ; #
fhir:type [ fhir:v "collection"] ; #
fhir:entry ( [
fhir:fullUrl [ fhir:v "urn:uuid:57a9af63-315d-1585-a261-0e337b289390"^^xsd:anyURI ] ;
( fhir:resource <urn:uuid:57a9af63-315d-1585-a261-0e337b289390> )
] ) . #
<urn:uuid:57a9af63-315d-1585-a261-0e337b289390> a fhir:SubstanceDefinition ;
fhir:id [ fhir:v "substancedefinition-substance-drug-pq-ex1"] ; #
fhir:text [
fhir:status [ fhir:v "extensions" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"SubstanceDefinition_substancedefinition-substance-drug-pq-ex1\"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name=\"substancedefinition-substance-drug-pq-ex1\"> </a><a name=\"hcsubstancedefinition-substance-drug-pq-ex1\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource SubstanceDefinition "substancedefinition-substance-drug-pq-ex1" </p></div><blockquote><p><b>property</b></p><p><b>type</b>: Appearance <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#appearance)</span></p><p><b>value</b>: white to slightly yellow powder <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Solubility purified water (PhEur) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#solubility-water-pheur)</span></p><p><b>value</b>: freely soluble <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-value-pq-example.html\">Substance Property Value - example</a>#sol-free "Freely soluble")</span></p></blockquote><blockquote><p><b>property</b></p><p><b>Extension - Substance Property Range PQ</b>: 23-27 mg/mL</p><p><b>type</b>: Solubility purified water (PhEur) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#solubility-water-pheur)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Solubility Acetone (PhEur) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#solubility-acetone-pheur)</span></p><p><b>value</b>: slightly soluble <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-value-pq-example.html\">Substance Property Value - example</a>#sol-slight "Slightly soluble")</span></p></blockquote><blockquote><p><b>property</b></p><p><b>Extension - Substance Property Range PQ</b>: 2-3 mg/mL</p><p><b>type</b>: Solubility acetone (PhEur) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#solubility-acetone-pheur)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Solubility Ethanol (PhEur) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#solubility-ethanol-pheur)</span></p><p><b>value</b>: soluble <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-value-pq-example.html\">Substance Property Value - example</a>#sol-soluble "Soluble")</span></p></blockquote><blockquote><p><b>property</b></p><p><b>Extension - Substance Property Range PQ</b>: 15-17 mg/mL</p><p><b>type</b>: Solubility ethanol (PhEur) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#solubility-ethanol-pheur)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Solubility at saturation in Purifed Water after 2 hours (approx) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#solubility-aq-water-2h-approx)</span></p><p><b>value</b>: 21 mg/mL</p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Glucose solution (5%) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#solubility-aq-glucose-2h-approx "Solubility at saturation in Glucose (5%) after 2 hours (approx)")</span></p><p><b>value</b>: 2.5 mg/mL</p></blockquote><blockquote><p><b>property</b></p><blockquote><p><b>Extension - Substance Property Parameter PQ</b></p><blockquote><p><b>url</b></p><code>parameter</code></blockquote><p><b>value</b>: pH (Details: http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example code pH = 'pH', stated as 'pH')</p><blockquote><p><b>url</b></p><code>value</code></blockquote><p><b>value</b>: 1.2</p></blockquote><p><b>type</b>: Solubility as a function of pH in USP buffers <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#solubility-usp-ph)</span></p><p><b>value</b>: 22 mg/mL</p></blockquote><blockquote><p><b>property</b></p><blockquote><p><b>Extension - Substance Property Parameter PQ</b></p><blockquote><p><b>url</b></p><code>parameter</code></blockquote><p><b>value</b>: pH (Details: http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example code pH = 'pH', stated as 'pH')</p><blockquote><p><b>url</b></p><code>value</code></blockquote><p><b>value</b>: 4.5</p></blockquote><p><b>type</b>: Solubility as a function of pH in USP buffers <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#solubility-usp-ph)</span></p><p><b>value</b>: 29 mg/mL</p></blockquote><blockquote><p><b>property</b></p><p><b>Extension - Substance Property Range PQ</b>: 6.7-6.8</p><blockquote><p><b>Extension - Substance Property Parameter PQ</b></p><blockquote><p><b>url</b></p><code>parameter</code></blockquote><p><b>value</b>: Concentration (Details: http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example code concentration = 'Concentration', stated as 'Concentration')</p><blockquote><p><b>url</b></p><code>value</code></blockquote><p><b>value</b>: 10 mg/ml</p></blockquote><blockquote><p><b>Extension - Substance Property Parameter PQ</b></p><blockquote><p><b>url</b></p><code>parameter</code></blockquote><p><b>value</b>: Temperature (Details: http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example code temperature = 'Temperature', stated as 'Temperature')</p><blockquote><p><b>url</b></p><code>value</code></blockquote><p><b>value</b>: 25 °C</p></blockquote><p><b>type</b>: pH in aqueous solution <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#ph-aq)</span></p></blockquote><blockquote><p><b>property</b></p><p><b>type</b>: Hygroscopy <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#hygroscopy)</span></p><p><b>value</b>: Hygroscopic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-cs-substance-property-pq-example.html\">Substance Property - example</a>#hygroscopy-hygroscopic)</span></p></blockquote><h3>Structures</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Stereochemistry</b></td></tr><tr><td style=\"display: none\">*</td><td>One asymmetric center and one axis of chirality; (S,M) - enantiomer <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>Stelbatolol</td></tr></table></div>"
] ; #
fhir:property ( [
fhir:type [
( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"^^xsd:anyURI ] ;
fhir:code [ fhir:v "appearance" ] ;
fhir:display [ fhir:v "Appearance" ] ] ) ] ;
fhir:value [
a fhir:CodeableConcept ;
fhir:text [ fhir:v "white to slightly yellow powder" ] ]
] [
fhir:type [
( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"^^xsd:anyURI ] ;
fhir:code [ fhir:v "solubility-water-pheur" ] ;
fhir:display [ fhir:v "Solubility purified water (PhEur)" ] ] ) ] ;
fhir:value [
a fhir:CodeableConcept ;
( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example"^^xsd:anyURI ] ;
fhir:code [ fhir:v "sol-free" ] ;
fhir:display [ fhir:v "Freely soluble" ] ] ) ;
fhir:text [ fhir:v "freely soluble" ] ]
] [
( fhir:extension [
fhir:url [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-substance-property-range-pq"^^xsd:anyURI ] ;
fhir:value [
a fhir:Range ;
fhir:low [
fhir:value [ fhir:v "23"^^xsd:decimal ] ;
fhir:unit [ fhir:v "mg/mL" ] ] ;
fhir:high [
fhir:value [ fhir:v "27"^^xsd:decimal ] ;
fhir:unit [ fhir:v "mg/mL" ] ] ] ] ) ;
fhir:type [
( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"^^xsd:anyURI ] ;
fhir:code [ fhir:v "solubility-water-pheur" ] ;
fhir:display [ fhir:v "Solubility purified water (PhEur)" ] ] ) ]
] [
fhir:type [
( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"^^xsd:anyURI ] ;
fhir:code [ fhir:v "solubility-acetone-pheur" ] ;
fhir:display [ fhir:v "Solubility Acetone (PhEur)" ] ] ) ] ;
fhir:value [
a fhir:CodeableConcept ;
( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example"^^xsd:anyURI ] ;
fhir:code [ fhir:v "sol-slight" ] ;
fhir:display [ fhir:v "Slightly soluble" ] ] ) ;
fhir:text [ fhir:v "slightly soluble" ] ]
] [
( fhir:extension [
fhir:url [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-substance-property-range-pq"^^xsd:anyURI ] ;
fhir:value [
a fhir:Range ;
fhir:low [
fhir:value [ fhir:v "2"^^xsd:decimal ] ;
fhir:unit [ fhir:v "mg/mL" ] ] ;
fhir:high [
fhir:value [ fhir:v "3"^^xsd:decimal ] ;
fhir:unit [ fhir:v "mg/mL" ] ] ] ] ) ;
fhir:type [
( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"^^xsd:anyURI ] ;
fhir:code [ fhir:v "solubility-acetone-pheur" ] ;
fhir:display [ fhir:v "Solubility acetone (PhEur)" ] ] ) ]
] [
fhir:type [
( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"^^xsd:anyURI ] ;
fhir:code [ fhir:v "solubility-ethanol-pheur" ] ;
fhir:display [ fhir:v "Solubility Ethanol (PhEur)" ] ] ) ] ;
fhir:value [
a fhir:CodeableConcept ;
( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-value-pq-example"^^xsd:anyURI ] ;
fhir:code [ fhir:v "sol-soluble" ] ;
fhir:display [ fhir:v "Soluble" ] ] ) ;
fhir:text [ fhir:v "soluble" ] ]
] [
( fhir:extension [
fhir:url [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-substance-property-range-pq"^^xsd:anyURI ] ;
fhir:value [
a fhir:Range ;
fhir:low [
fhir:value [ fhir:v "15"^^xsd:decimal ] ;
fhir:unit [ fhir:v "mg/mL" ] ] ;
fhir:high [
fhir:value [ fhir:v "17"^^xsd:decimal ] ;
fhir:unit [ fhir:v "mg/mL" ] ] ] ] ) ;
fhir:type [
( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"^^xsd:anyURI ] ;
fhir:code [ fhir:v "solubility-ethanol-pheur" ] ;
fhir:display [ fhir:v "Solubility ethanol (PhEur)" ] ] ) ]
] [
fhir:type [
( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"^^xsd:anyURI ] ;
fhir:code [ fhir:v "solubility-aq-water-2h-approx" ] ;
fhir:display [ fhir:v "Solubility at saturation in Purifed Water after 2 hours (approx)" ] ] ) ] ;
fhir:value [
a fhir:Quantity ;
fhir:value [ fhir:v "21"^^xsd:decimal ] ;
fhir:unit [ fhir:v "mg/mL" ] ]
] [
fhir:type [
( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"^^xsd:anyURI ] ;
fhir:code [ fhir:v "solubility-aq-glucose-2h-approx" ] ;
fhir:display [ fhir:v "Solubility at saturation in Glucose (5%) after 2 hours (approx)" ] ] ) ;
fhir:text [ fhir:v "Glucose solution (5%)" ] ] ;
fhir:value [
a fhir:Quantity ;
fhir:value [ fhir:v "2.5"^^xsd:decimal ] ;
fhir:unit [ fhir:v "mg/mL" ] ]
] [
( fhir:extension [
fhir:url [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-substance-property-parameter-pq"^^xsd:anyURI ] ;
( fhir:extension [
fhir:url [ fhir:v "parameter"^^xsd:anyURI ] ;
fhir:value [
a fhir:Coding ;
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"^^xsd:anyURI ] ;
fhir:code [ fhir:v "pH" ] ;
fhir:display [ fhir:v "pH" ] ] ] [
fhir:url [ fhir:v "value"^^xsd:anyURI ] ;
fhir:value [
a fhir:Quantity ;
fhir:value [ fhir:v "1.2"^^xsd:decimal ] ] ] ) ] ) ;
fhir:type [
( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"^^xsd:anyURI ] ;
fhir:code [ fhir:v "solubility-usp-ph" ] ;
fhir:display [ fhir:v "Solubility as a function of pH in USP buffers" ] ] ) ] ;
fhir:value [
a fhir:Quantity ;
fhir:value [ fhir:v "22"^^xsd:decimal ] ;
fhir:unit [ fhir:v "mg/mL" ] ]
] [
( fhir:extension [
fhir:url [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-substance-property-parameter-pq"^^xsd:anyURI ] ;
( fhir:extension [
fhir:url [ fhir:v "parameter"^^xsd:anyURI ] ;
fhir:value [
a fhir:Coding ;
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"^^xsd:anyURI ] ;
fhir:code [ fhir:v "pH" ] ;
fhir:display [ fhir:v "pH" ] ] ] [
fhir:url [ fhir:v "value"^^xsd:anyURI ] ;
fhir:value [
a fhir:Quantity ;
fhir:value [ fhir:v "4.5"^^xsd:decimal ] ] ] ) ] ) ;
fhir:type [
( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"^^xsd:anyURI ] ;
fhir:code [ fhir:v "solubility-usp-ph" ] ;
fhir:display [ fhir:v "Solubility as a function of pH in USP buffers" ] ] ) ] ;
fhir:value [
a fhir:Quantity ;
fhir:value [ fhir:v "29"^^xsd:decimal ] ;
fhir:unit [ fhir:v "mg/mL" ] ]
] [
( fhir:extension [
fhir:url [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-substance-property-range-pq"^^xsd:anyURI ] ;
fhir:value [
a fhir:Range ;
fhir:low [
fhir:value [ fhir:v "6.7"^^xsd:decimal ] ] ;
fhir:high [
fhir:value [ fhir:v "6.8"^^xsd:decimal ] ] ] ] [
fhir:url [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-substance-property-parameter-pq"^^xsd:anyURI ] ;
( fhir:extension [
fhir:url [ fhir:v "parameter"^^xsd:anyURI ] ;
fhir:value [
a fhir:Coding ;
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"^^xsd:anyURI ] ;
fhir:code [ fhir:v "concentration" ] ;
fhir:display [ fhir:v "Concentration" ] ] ] [
fhir:url [ fhir:v "value"^^xsd:anyURI ] ;
fhir:value [
a fhir:Quantity ;
fhir:value [ fhir:v "10"^^xsd:decimal ] ;
fhir:unit [ fhir:v "mg/ml" ] ] ] ) ] [
fhir:url [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-substance-property-parameter-pq"^^xsd:anyURI ] ;
( fhir:extension [
fhir:url [ fhir:v "parameter"^^xsd:anyURI ] ;
fhir:value [
a fhir:Coding ;
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"^^xsd:anyURI ] ;
fhir:code [ fhir:v "temperature" ] ;
fhir:display [ fhir:v "Temperature" ] ] ] [
fhir:url [ fhir:v "value"^^xsd:anyURI ] ;
fhir:value [
a fhir:Quantity ;
fhir:value [ fhir:v "25"^^xsd:decimal ] ;
fhir:unit [ fhir:v "°C" ] ] ] ) ] ) ;
fhir:type [
( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"^^xsd:anyURI ] ;
fhir:code [ fhir:v "ph-aq" ] ;
fhir:display [ fhir:v "pH in aqueous solution" ] ] ) ]
] [
fhir:type [
( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"^^xsd:anyURI ] ;
fhir:code [ fhir:v "hygroscopy" ] ;
fhir:display [ fhir:v "Hygroscopy" ] ] ) ] ;
fhir:value [
a fhir:CodeableConcept ;
( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-substance-property-pq-example"^^xsd:anyURI ] ;
fhir:code [ fhir:v "hygroscopy-hygroscopic" ] ;
fhir:display [ fhir:v "Hygroscopic" ] ] ) ;
fhir:text [ fhir:v "Hygroscopic" ] ]
] ) ; #
fhir:structure [
fhir:stereochemistry [
fhir:text [ fhir:v "One asymmetric center and one axis of chirality; (S,M) - enantiomer" ] ]
] ; #
fhir:name ( [
fhir:name [ fhir:v "Stelbatolol" ]
] ) . #
IG © HL7 International / Biomedical Research and Regulation. Package hl7.fhir.uv.pharm-quality#1.0.0 based on FHIR 5.0.0. Generated 2024-05-08
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