Generated Narrative

category: Laboratory

code: Therapeutic Implication

derivedFrom:

• CYP2C9*1/*1. Generated Summary: Laboratory; Genotype display name; effective: 2020-01-01; CYP2C9*1/*1
• VKORC1 rs9923231 C/T. Generated Summary: Laboratory; Genotype display name; effective: 2020-01-01; VKORC1 rs9923231 C/T

component

code: Medication assessed [ID]

value: warfarin

component

code: Genetic variation's effect on drug metabolism

value: Normal metabolizer

component

code: Conclusion text

value: This individual is homozygous for the normal allele for the CYP2C9 gene. Based on the genotype result, this patient is predicted to have normal CYP2C9 function. This individual is also heterozygous for the variant allele for the VKORC1 gene. Expression level of the VKORC1 gene is associated with warfarin sensitivity. Based on the genotype result, this patient is predicted to have medium sensitivity to warfarin. See https://cpicpgx.org/guidelines/guideline-for-warfarin-and-cyp2c9-and-vkorc1/ guidelines for detail.