Generated Narrative

category: Laboratory

code: Therapeutic Implication

derivedFrom: Generated Summary: Laboratory; Genotype display name; effective: 2020-01-01; CYP2C19*2/*2

component

code: Medication assessed [ID]

value: amitriptyline

component

code: Genetic variation's effect on drug metabolism

value: Poor metabolizer

component

code: Conclusion text

value: For amitriptyline, a 50% reduction in starting dose is recommended with therapeutic drug monitoring to guide dose adjustment. Refer to current guidelines for dosage and recommendations at https://cpicpgx.org/guidelines/guideline-for- tricyclic-antidepressants-and-cyp2d6-and-cyp2c19/. If CYP2D6 genotyping is available, refer to the current guidelines for dosing recommendations.