This page is part of the Genetic Reporting Implementation Guide (v1.1.0: STU 2 Ballot 1) based on FHIR R4. The current version which supercedes this version is 2.0.0. For a full list of available versions, see the Directory of published versions

• Narrative Content
• XML
• JSON
• TTL

: Example - CYP2C19 report from 1000 Genomes - XML Representation

Raw xml | Download

<DiagnosticReport xmlns="http://hl7.org/fhir">
  <id value="report-CYP2C19"/>
  <meta>
    <profile
             value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomics-report"/>
  </meta>
  <text>
    <status value="generated"/>
    <div xmlns="http://www.w3.org/1999/xhtml"><h2><span title="Codes: {http://loinc.org 81247-9}">Genetic analysis report</span> (<span title="Codes: {http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span>) </h2><table class="grid"></table><p><b>Report Details</b></p><table class="grid"><tr><td><b>Code</b></td><td><b>Value</b></td><td><b>Reported</b></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr><tr><td colspan="3"><i>This Observation could not be resolved</i></td></tr></table></div>
  </text>
  <contained>
    <Observation>
      <id value="rs-5c7e9e1ca6214"/>
      <meta>
        <profile
                 value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/region-studied"/>
      </meta>
      <status value="final"/>
      <category>
        <coding>
          <system
                  value="http://terminology.hl7.org/CodeSystem/observation-category"/>
          <code value="laboratory"/>
        </coding>
      </category>
      <code>
        <coding>
          <system value="http://loinc.org"/>
          <code value="53041-0"/>
          <display value="DNA Region of interest panel"/>
        </coding>
      </code>
      <issued value="2019-03-05T16:04:44+00:00"/>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="48018-6"/>
            <display value="Gene studied ID"/>
          </coding>
        </code>
        <valueCodeableConcept>
          <coding>
            <system value="http://www.genenames.org/geneId"/>
            <code value="HGNC:2621"/>
            <display value="CYP2C19"/>
          </coding>
        </valueCodeableConcept>
      </component>
    </Observation>
  </contained>
  <contained>
    <Observation>
      <id value="dv-5c7e9e1ca62b5"/>
      <meta>
        <profile
                 value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant"/>
      </meta>
      <status value="final"/>
      <category>
        <coding>
          <system
                  value="http://terminology.hl7.org/CodeSystem/observation-category"/>
          <code value="laboratory"/>
        </coding>
      </category>
      <code>
        <coding>
          <system value="http://loinc.org"/>
          <code value="69548-6"/>
          <display value="Genetic variant assessment"/>
        </coding>
      </code>
      <issued value="2019-03-05T16:04:44+00:00"/>
      <valueCodeableConcept>
        <coding>
          <system value="http://loinc.org"/>
          <code value="LA9633-4"/>
          <display value="Present"/>
        </coding>
      </valueCodeableConcept>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="62374-4"/>
            <display value="Human reference sequence assembly version"/>
          </coding>
        </code>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA14029-5"/>
            <display value="GRCh37"/>
          </coding>
        </valueCodeableConcept>
      </component>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="48013-7"/>
            <display value="Genomic reference sequence ID"/>
          </coding>
        </code>
        <valueCodeableConcept>
          <coding>
            <system value="http://www.ncbi.nlm.nih.gov/nuccore"/>
            <code value="NC_000010.10"/>
          </coding>
        </valueCodeableConcept>
      </component>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="53034-5"/>
            <display value="Allelic state"/>
          </coding>
        </code>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA6706-1"/>
            <display value="heterozygous"/>
          </coding>
        </valueCodeableConcept>
      </component>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="69547-8"/>
            <display value="Ref nucleotide"/>
          </coding>
        </code>
        <valueString value="A"/>
      </component>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="69551-0"/>
            <display value="Alt allele"/>
          </coding>
        </code>
        <valueString value="G"/>
      </component>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="92822-6"/>
            <display value="Genomic coord system"/>
          </coding>
        </code>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA30102-0"/>
          </coding>
        </valueCodeableConcept>
      </component>
      <component>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/TbdCodes"/>
            <code value="exact-start-end"/>
            <display value="Variant exact start and end"/>
          </coding>
        </code>
        <valueRange>
          <low>
            <value value="96448129"/>
          </low>
        </valueRange>
      </component>
    </Observation>
  </contained>
  <contained>
    <Observation>
      <id value="dv-5c7e9e1ca6342"/>
      <meta>
        <profile
                 value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant"/>
      </meta>
      <status value="final"/>
      <category>
        <coding>
          <system
                  value="http://terminology.hl7.org/CodeSystem/observation-category"/>
          <code value="laboratory"/>
        </coding>
      </category>
      <code>
        <coding>
          <system value="http://loinc.org"/>
          <code value="69548-6"/>
          <display value="Genetic variant assessment"/>
        </coding>
      </code>
      <issued value="2019-03-05T16:04:44+00:00"/>
      <valueCodeableConcept>
        <coding>
          <system value="http://loinc.org"/>
          <code value="LA9633-4"/>
          <display value="Present"/>
        </coding>
      </valueCodeableConcept>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="62374-4"/>
            <display value="Human reference sequence assembly version"/>
          </coding>
        </code>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA14029-5"/>
            <display value="GRCh37"/>
          </coding>
        </valueCodeableConcept>
      </component>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="48013-7"/>
            <display value="Genomic reference sequence ID"/>
          </coding>
        </code>
        <valueCodeableConcept>
          <coding>
            <system value="http://www.ncbi.nlm.nih.gov/nuccore"/>
            <code value="NC_000010.10"/>
          </coding>
        </valueCodeableConcept>
      </component>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="53034-5"/>
            <display value="Allelic state"/>
          </coding>
        </code>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA6706-1"/>
            <display value="heterozygous"/>
          </coding>
        </valueCodeableConcept>
      </component>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="69547-8"/>
            <display value="Ref nucleotide"/>
          </coding>
        </code>
        <valueString value="C"/>
      </component>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="69551-0"/>
            <display value="Alt allele"/>
          </coding>
        </code>
        <valueString value="G"/>
      </component>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="92822-6"/>
            <display value="Genomic coord system"/>
          </coding>
        </code>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA30102-0"/>
          </coding>
        </valueCodeableConcept>
      </component>
      <component>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/TbdCodes"/>
            <code value="exact-start-end"/>
            <display value="Variant exact start and end"/>
          </coding>
        </code>
        <valueRange>
          <low>
            <value value="96448380"/>
          </low>
        </valueRange>
      </component>
    </Observation>
  </contained>
  <contained>
    <Observation>
      <id value="dv-5c7e9e1ca63bf"/>
      <meta>
        <profile
                 value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant"/>
      </meta>
      <status value="final"/>
      <category>
        <coding>
          <system
                  value="http://terminology.hl7.org/CodeSystem/observation-category"/>
          <code value="laboratory"/>
        </coding>
      </category>
      <code>
        <coding>
          <system value="http://loinc.org"/>
          <code value="69548-6"/>
          <display value="Genetic variant assessment"/>
        </coding>
      </code>
      <issued value="2019-03-05T16:04:44+00:00"/>
      <valueCodeableConcept>
        <coding>
          <system value="http://loinc.org"/>
          <code value="LA9633-4"/>
          <display value="Present"/>
        </coding>
      </valueCodeableConcept>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="62374-4"/>
            <display value="Human reference sequence assembly version"/>
          </coding>
        </code>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA14029-5"/>
            <display value="GRCh37"/>
          </coding>
        </valueCodeableConcept>
      </component>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="48013-7"/>
            <display value="Genomic reference sequence ID"/>
          </coding>
        </code>
        <valueCodeableConcept>
          <coding>
            <system value="http://www.ncbi.nlm.nih.gov/nuccore"/>
            <code value="NC_000010.10"/>
          </coding>
        </valueCodeableConcept>
      </component>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="53034-5"/>
            <display value="Allelic state"/>
          </coding>
        </code>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA6706-1"/>
            <display value="heterozygous"/>
          </coding>
        </valueCodeableConcept>
      </component>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="69547-8"/>
            <display value="Ref nucleotide"/>
          </coding>
        </code>
        <valueString value="A"/>
      </component>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="69551-0"/>
            <display value="Alt allele"/>
          </coding>
        </code>
        <valueString value="C"/>
      </component>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="92822-6"/>
            <display value="Genomic coord system"/>
          </coding>
        </code>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA30102-0"/>
          </coding>
        </valueCodeableConcept>
      </component>
      <component>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/TbdCodes"/>
            <code value="exact-start-end"/>
            <display value="Variant exact start and end"/>
          </coding>
        </code>
        <valueRange>
          <low>
            <value value="96448994"/>
          </low>
        </valueRange>
      </component>
    </Observation>
  </contained>
  <contained>
    <Observation>
      <id value="dv-5c7e9e1ca643a"/>
      <meta>
        <profile
                 value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant"/>
      </meta>
      <status value="final"/>
      <category>
        <coding>
          <system
                  value="http://terminology.hl7.org/CodeSystem/observation-category"/>
          <code value="laboratory"/>
        </coding>
      </category>
      <code>
        <coding>
          <system value="http://loinc.org"/>
          <code value="69548-6"/>
          <display value="Genetic variant assessment"/>
        </coding>
      </code>
      <issued value="2019-03-05T16:04:44+00:00"/>
      <valueCodeableConcept>
        <coding>
          <system value="http://loinc.org"/>
          <code value="LA9633-4"/>
          <display value="Present"/>
        </coding>
      </valueCodeableConcept>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="62374-4"/>
            <display value="Human reference sequence assembly version"/>
          </coding>
        </code>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA14029-5"/>
            <display value="GRCh37"/>
          </coding>
        </valueCodeableConcept>
      </component>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="48013-7"/>
            <display value="Genomic reference sequence ID"/>
          </coding>
        </code>
        <valueCodeableConcept>
          <coding>
            <system value="http://www.ncbi.nlm.nih.gov/nuccore"/>
            <code value="NC_000010.10"/>
          </coding>
        </valueCodeableConcept>
      </component>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="53034-5"/>
            <display value="Allelic state"/>
          </coding>
        </code>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA6706-1"/>
            <display value="heterozygous"/>
          </coding>
        </valueCodeableConcept>
      </component>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="69547-8"/>
            <display value="Ref nucleotide"/>
          </coding>
        </code>
        <valueString value="G"/>
      </component>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="69551-0"/>
            <display value="Alt allele"/>
          </coding>
        </code>
        <valueString value="A"/>
      </component>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="92822-6"/>
            <display value="Genomic coord system"/>
          </coding>
        </code>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA30102-0"/>
          </coding>
        </valueCodeableConcept>
      </component>
      <component>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/TbdCodes"/>
            <code value="exact-start-end"/>
            <display value="Variant exact start and end"/>
          </coding>
        </code>
        <valueRange>
          <low>
            <value value="96454156"/>
          </low>
        </valueRange>
      </component>
    </Observation>
  </contained>
  <contained>
    <Observation>
      <id value="dv-5c7e9e1ca64b5"/>
      <meta>
        <profile
                 value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant"/>
      </meta>
      <status value="final"/>
      <category>
        <coding>
          <system
                  value="http://terminology.hl7.org/CodeSystem/observation-category"/>
          <code value="laboratory"/>
        </coding>
      </category>
      <code>
        <coding>
          <system value="http://loinc.org"/>
          <code value="69548-6"/>
          <display value="Genetic variant assessment"/>
        </coding>
      </code>
      <issued value="2019-03-05T16:04:44+00:00"/>
      <valueCodeableConcept>
        <coding>
          <system value="http://loinc.org"/>
          <code value="LA9633-4"/>
          <display value="Present"/>
        </coding>
      </valueCodeableConcept>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="62374-4"/>
            <display value="Human reference sequence assembly version"/>
          </coding>
        </code>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA14029-5"/>
            <display value="GRCh37"/>
          </coding>
        </valueCodeableConcept>
      </component>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="48013-7"/>
            <display value="Genomic reference sequence ID"/>
          </coding>
        </code>
        <valueCodeableConcept>
          <coding>
            <system value="http://www.ncbi.nlm.nih.gov/nuccore"/>
            <code value="NC_000010.10"/>
          </coding>
        </valueCodeableConcept>
      </component>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="53034-5"/>
            <display value="Allelic state"/>
          </coding>
        </code>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA6705-3"/>
            <display value="homozygous"/>
          </coding>
        </valueCodeableConcept>
      </component>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="69547-8"/>
            <display value="Ref nucleotide"/>
          </coding>
        </code>
        <valueString value="G"/>
      </component>
      <component>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="69551-0"/>
            <display value="Alt allele"/>
          </coding>
        </code>
        <valueString value="A"/>
      </component>
      <component>
        <code>
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