A single issue - either an indication, contraindication, interaction or an undesirable effect for a medicinal product, medication, device or procedure.

Business identifier for this issue.

indication | contraindication | interaction | undesirable-effect | warning.

A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy and Lactation", "Overdose", "Effects on Ability to Drive and Use Machines".

The medication, product, substance, device, procedure etc. for which this is an indication.

Whether this is a current issue or one that has been retired etc.

Specifics for when this is a contraindication.

The situation that is being documented as contraindicating against this item.

The status of the disease or symptom for the contraindication, for example "chronic" or "metastatic".

A comorbidity (concurrent condition) or coinfection.

The indication which this is a contraidication for.

An expression that returns true or false, indicating whether the indication is applicable or not, after having applied its other elements.

The expression may be inlined or may be a reference to a named expression within a logic library referenced by the library element.

Information about the use of the medicinal product in relation to other therapies described as part of the contraindication.

The type of relationship between the medicinal product indication or contraindication and another therapy.

Reference to a specific medication (active substance, medicinal product or class of products, biological, food etc.) as part of an indication or contraindication.

Specifics for when this is an indication.

The situation that is being documented as an indicaton for this item.

The status of the disease or symptom for the indication, for example "chronic" or "metastatic".

A comorbidity (concurrent condition) or coinfection as part of the indication.

The intended effect, aim or strategy to be achieved.

Timing or duration information, that may be associated with use with the indicated condition e.g. Adult patients suffering from myocardial infarction (from a few days until less than 35 days), ischaemic stroke (from 7 days until less than 6 months).

An unwanted side effect or negative outcome that may happen if you use the drug (or other subject of this resource) for this indication.

An expression that returns true or false, indicating whether the indication is applicable or not, after having applied its other elements.

The expression may be inlined or may be a reference to a named expression within a logic library referenced by the library element.

Information about the use of the medicinal product in relation to other therapies described as part of the indication.

Specifics for when this is an interaction.

The specific medication, product, food, substance etc. or laboratory test that interacts.

The specific medication, product, food, substance etc. or laboratory test that interacts.

The type of the interaction e.g. drug-drug interaction, drug-food interaction, drug-lab test interaction.

The effect of the interaction, for example "reduced gastric absorption of primary medication".

The incidence of the interaction, e.g. theoretical, observed.

Actions for managing the interaction.

The population group to which this applies.

Logic used by the clinical use definition.

Describe the possible undesirable effects (negative outcomes) from the use of the medicinal product as treatment.

The situation in which the undesirable effect may manifest.

High level classification of the effect.

How often the effect is seen.

A critical piece of information about environmental, health or physical risks or hazards that serve as caution to the user. For example 'Do not operate heavy machinery', 'May cause drowsiness', or 'Get medical advice/attention if you feel unwell'.

A textual definition of this warning, with formatting.

A coded or unformatted textual definition of this warning.