Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot - ballot
Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot - ballot
This page is part of the Evidence Based Medicine on FHIR Implementation Guide (v1.0.0-ballot: STU1 Ballot 1) based on FHIR (HL7® FHIR® Standard) v5.0.0. . For a full list of available versions, see the Directory of published versions
| Active as of 2023-12-17 |
<Evidence xmlns="http://hl7.org/fhir">
<id value="179588"/>
<meta>
<versionId value="6"/>
<lastUpdated value="2023-12-08T13:32:26.958Z"/>
<profile
value="http://hl7.org/fhir/uv/ebm/StructureDefinition/net-effect-contribution"/>
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<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Evidence</b><a name="179588"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Evidence "179588" Version "6" Updated "2023-12-08 13:32:26+0000" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-net-effect-contribution.html">NetEffectContribution</a></p></div><p><b>StructureDefinition Work Group</b>: cds</p><p><b>url</b>: <code>https://fevir.net/resources/Evidence/179588</code></p><p><b>identifier</b>: FEvIR Object Identifier: 179588</p><p><b>version</b>: 1.0.0-ballot</p><p><b>name</b>: NetEffectContribution_Remission_of_diabetes_for_Example_for_GIN_2022</p><p><b>title</b>: NetEffectContribution: Remission of diabetes for Example for GIN 2022</p><p><b>status</b>: active</p><p><b>date</b>: 2023-12-17 16:55:23+0000</p><p><b>publisher</b>: HL7 International / Clinical Decision Support</p><p><b>contact</b>: HL7 International / Clinical Decision Support: <a href="http://www.hl7.org/Special/committees/dss">http://www.hl7.org/Special/committees/dss</a></p><p><b>author</b>: Brian S. Alper: </p><h3>UseContexts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Evidence Communication (Details: https://fevir.net/resources/CodeSystem/179423 code evidence-communication = 'Evidence Communication', stated as 'Evidence Communication')</td><td>ComparativeEvidence <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-179423.html">Evidence Based Medicine on FHIR Implementation Guide Code System</a>#ComparativeEvidence)</span></td></tr><tr><td style="display: none">*</td><td>Evidence Communication (Details: https://fevir.net/resources/CodeSystem/179423 code evidence-communication = 'Evidence Communication', stated as 'Evidence Communication')</td><td>NetEffectContribution <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-179423.html">Evidence Based Medicine on FHIR Implementation Guide Code System</a>#NetEffectContribution)</span></td></tr></table><p><b>copyright</b>: https://creativecommons.org/licenses/by-nc-sa/4.0/</p><h3>RelatedArtifacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Citation</b></td><td><b>ResourceReference</b></td></tr><tr><td style="display: none">*</td><td>cite-as</td><td>NetEffectContribution: Remission of diabetes for Example for GIN 2022 [Evidence]. Contributors: Brian S. Alper [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 179588. Revised 2023-12-06. Available at: https://fevir.net/resources/Evidence/179588. Computable resource at: https://fevir.net/resources/Evidence/179588.</td><td> </td></tr><tr><td style="display: none">*</td><td>amended-with</td><td> </td><td><a href="ArtifactAssessment-104193.html">ArtifactAssessment/104193: Outcome Importance Rating (default value 5) of Remission of diabetes</a></td></tr></table><p><b>description</b>: 2.15 (1.33 to 3.26) - example showing statistic.extension:modelExpression</p><blockquote><p><b>variableDefinition</b></p><p><b>VariableDefinitionVariableRoleCode</b>: population</p><p><b>description</b>: Cohort study with baseline data of exposures from November 2005 through July 2010 and follow-up data from 2006 until death or through December 2015 at a tertiary care outpatient center, Vestfold Hospital Trust, Norway. Consecutive treatment-seeking adult patients (n = 2109) with severe obesity assessed (221 patients excluded and 1888 patients included).</p><p><b>note</b>: population</p><p><b>variableRole</b>: Use extension:variableRoleCode instead. <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-variable-role.html">EvidenceVariableRole</a>#population "population")</span></p><p><b>observed</b>: <a href="Group-178427.html">Group/178427: StudyGroup: Severely Obese Adults 2018 Norwegian Cohort</a> "Severely_Obese_Adults_2018_Norwegian_Cohort"</p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>VariableDefinitionVariableRoleCode</b>: exposure</p><p><b>VariableDefinitionComparatorCategory</b>: no bariatric surgery</p><p><b>description</b>: comparison groups of bariatric surgery vs. no bariatric surgery</p><p><b>note</b>: exposure</p><p><b>variableRole</b>: Use extension:variableRoleCode instead. <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-variable-role.html">EvidenceVariableRole</a>#exposure "exposure")</span></p><p><b>observed</b>: <a href="EvidenceVariable-172427.html">EvidenceVariable/172427: GroupAssignment: Bariatric Surgery vs. no bariatric surgery</a> "GroupAssignment_Bariatric_Surgery_vs_no_bariatric_surgery"</p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>VariableDefinitionVariableRoleCode</b>: outcome</p><p><b>description</b>: Remission of diabetes</p><p><b>note</b>: outcome</p><p><b>variableRole</b>: Use extension:variableRoleCode instead. <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-variable-role.html">EvidenceVariableRole</a>#measuredVariable "measured variable")</span></p><p><b>observed</b>: <a href="EvidenceVariable-104117.html">EvidenceVariable/104117: OutcomeVariable: Remission of diabetes</a> "OutcomeVariable_Remission_of_diabetes"</p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>VariableDefinitionVariableRoleCode</b>: covariate</p><p><b>VariableDefinitionRoleSubtype</b>: Relative importance multiplier <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-179423.html">Evidence Based Medicine on FHIR Implementation Guide Code System</a>#importance-multiplier)</span></p><p><b>description</b>: Relative Importance Multiplier</p><p><b>note</b>: covariate</p><p><b>variableRole</b>: Use extension:variableRoleCode instead. <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-variable-role.html">EvidenceVariableRole</a>#confounder "confounder")</span></p><p><b>observed</b>: <span>: Relative Importance Multiplier</span></p></blockquote><blockquote><p><b>statistic</b></p><p><b>StatisticModelExpression</b>: <code>Evidence[id='104121'].statistic[statisticType='Relative Risk'] * Evidence[id='104396'].statistic[statisticType='Proportion'] * $this.relatedArtifact[type=#amended-with].resourceReference(processOutcomeImportance)</code>(<b>Net effect contribution analysis</b>"risk difference (relative risk x control event rate) multiplied by relative importance multiplier (defined in OutcomeImportance Profile) -- expression is pseudocode to demonstrate the concept")</p><p><b>description</b>: risk difference 2.15 (95% CI 1.33 to 3.26)</p><p><b>statisticType</b>: Risk Difference <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-181513.html">Scientific Evidence Code System (SEVCO) -- EXAMPLE VERSION for EBMonFHIR Implementation Guide</a>#STATO:0000424)</span></p><p><b>quantity</b>: 2.15</p><h3>AttributeEstimates</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Description</b></td><td><b>Type</b></td><td><b>Level</b></td><td><b>Range</b></td></tr><tr><td style="display: none">*</td><td>95% CI 1.33 to 3.26</td><td>confidence interval <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-181513.html">Scientific Evidence Code System (SEVCO) -- EXAMPLE VERSION for EBMonFHIR Implementation Guide</a>#STATO:0000196)</span></td><td>0.95</td><td>1.33-3.26</td></tr></table><h3>ModelCharacteristics</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td></tr><tr><td style="display: none">*</td><td>Net effect contribution analysis <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-181513.html">Scientific Evidence Code System (SEVCO) -- EXAMPLE VERSION for EBMonFHIR Implementation Guide</a>#TBD:net-effect-contribution-analysis)</span></td></tr></table></blockquote></div>
</text>
<extension
url="http://hl7.org/fhir/StructureDefinition/structuredefinition-wg">
<valueCode value="cds"/>
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<url value="https://fevir.net/resources/Evidence/179588"/>
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<system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
<code value="ACSN"/>
<display value="Accession ID"/>
</coding>
<text value="FEvIR Object Identifier"/>
</type>
<system value="https://fevir.net"/>
<value value="179588"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<version value="1.0.0-ballot"/>
<name
value="NetEffectContribution_Remission_of_diabetes_for_Example_for_GIN_2022"/>
<title
value="NetEffectContribution: Remission of diabetes for Example for GIN 2022"/>
<status value="active"/>
<date value="2023-12-17T16:55:23+00:00"/>
<publisher value="HL7 International / Clinical Decision Support"/>
<contact>
<name value="HL7 International / Clinical Decision Support"/>
<telecom>
<system value="url"/>
<value value="http://www.hl7.org/Special/committees/dss"/>
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<author>
<name value="Brian S. Alper"/>
</author>
<useContext>
<code>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="evidence-communication"/>
<display value="Evidence Communication"/>
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<valueCodeableConcept>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="ComparativeEvidence"/>
<display value="ComparativeEvidence"/>
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</useContext>
<useContext>
<code>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="evidence-communication"/>
<display value="Evidence Communication"/>
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<valueCodeableConcept>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="NetEffectContribution"/>
<display value="NetEffectContribution"/>
</coding>
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<copyright value="https://creativecommons.org/licenses/by-nc-sa/4.0/"/>
<relatedArtifact>
<type value="cite-as"/>
<citation
value="NetEffectContribution: Remission of diabetes for Example for GIN 2022 [Evidence]. Contributors: Brian S. Alper [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 179588. Revised 2023-12-06. Available at: https://fevir.net/resources/Evidence/179588. Computable resource at: https://fevir.net/resources/Evidence/179588."/>
</relatedArtifact>
<relatedArtifact>
<type value="amended-with"/>
<resourceReference>🔗
<reference value="ArtifactAssessment/104193"/>
<type value="ArtifactAssessment"/>
<display
value="Outcome Importance Rating (default value 5) of Remission of diabetes"/>
</resourceReference>
</relatedArtifact>
<description
value="2.15 (1.33 to 3.26) - example showing statistic.extension:modelExpression"/>
<variableDefinition>
<extension
url="http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code">
<valueCode value="population"/>
</extension>
<description
value="Cohort study with baseline data of exposures from November 2005 through July 2010 and follow-up data from 2006 until death or through December 2015 at a tertiary care outpatient center, Vestfold Hospital Trust, Norway. Consecutive treatment-seeking adult patients (n = 2109) with severe obesity assessed (221 patients excluded and 1888 patients included)."/>
<note>
<text value="population"/>
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<variableRole>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/variable-role"/>
<code value="population"/>
<display value="population"/>
</coding>
<text value="Use extension:variableRoleCode instead."/>
</variableRole>
<observed>🔗
<reference value="Group/178427"/>
<type value="Group"/>
<display
value="StudyGroup: Severely Obese Adults 2018 Norwegian Cohort"/>
</observed>
</variableDefinition>
<variableDefinition>
<extension
url="http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code">
<valueCode value="exposure"/>
</extension>
<extension
url="http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-comparator-category">
<valueString value="no bariatric surgery"/>
</extension>
<description
value="comparison groups of bariatric surgery vs. no bariatric surgery"/>
<note>
<text value="exposure"/>
</note>
<variableRole>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/variable-role"/>
<code value="exposure"/>
<display value="exposure"/>
</coding>
<text value="Use extension:variableRoleCode instead."/>
</variableRole>
<observed>🔗
<reference value="EvidenceVariable/172427"/>
<type value="EvidenceVariable"/>
<display
value="GroupAssignment: Bariatric Surgery vs. no bariatric surgery"/>
</observed>
</variableDefinition>
<variableDefinition>
<extension
url="http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code">
<valueCode value="outcome"/>
</extension>
<description value="Remission of diabetes"/>
<note>
<text value="outcome"/>
</note>
<variableRole>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/variable-role"/>
<code value="measuredVariable"/>
<display value="measured variable"/>
</coding>
<text value="Use extension:variableRoleCode instead."/>
</variableRole>
<observed>🔗
<reference value="EvidenceVariable/104117"/>
<type value="EvidenceVariable"/>
<display value="OutcomeVariable: Remission of diabetes"/>
</observed>
</variableDefinition>
<variableDefinition>
<extension
url="http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code">
<valueCode value="covariate"/>
</extension>
<extension
url="http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype">
<valueCodeableConcept>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="importance-multiplier"/>
<display value="Relative importance multiplier"/>
</coding>
</valueCodeableConcept>
</extension>
<description value="Relative Importance Multiplier"/>
<note>
<text value="covariate"/>
</note>
<variableRole>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/variable-role"/>
<code value="confounder"/>
<display value="confounder"/>
</coding>
<text value="Use extension:variableRoleCode instead."/>
</variableRole>
<observed>
<display value="Relative Importance Multiplier"/>
</observed>
</variableDefinition>
<statistic>
<extension
url="http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-expression">
<valueExpression>
<description
value="risk difference (relative risk x control event rate) multiplied by relative importance multiplier (defined in OutcomeImportance Profile) -- expression is pseudocode to demonstrate the concept"/>
<name value="Net effect contribution analysis"/>
<expression
value="Evidence[id='104121'].statistic[statisticType='Relative Risk'] * Evidence[id='104396'].statistic[statisticType='Proportion'] * $this.relatedArtifact[type=#amended-with].resourceReference(processOutcomeImportance)"/>
</valueExpression>
</extension>
<description value="risk difference 2.15 (95% CI 1.33 to 3.26)"/>
<statisticType>
<coding>
<system value="https://fevir.net/resources/CodeSystem/181513"/>
<code value="STATO:0000424"/>
<display value="Risk Difference"/>
</coding>
</statisticType>
<quantity>
<value value="2.15"/>
</quantity>
<attributeEstimate>
<description value="95% CI 1.33 to 3.26"/>
<type>
<coding>
<system value="https://fevir.net/resources/CodeSystem/181513"/>
<code value="STATO:0000196"/>
<display value="confidence interval"/>
</coding>
</type>
<level value="0.95"/>
<range>
<low>
<value value="1.33"/>
</low>
<high>
<value value="3.26"/>
</high>
</range>
</attributeEstimate>
<modelCharacteristic>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/181513"/>
<code value="TBD:net-effect-contribution-analysis"/>
<display value="Net effect contribution analysis"/>
</coding>
</code>
</modelCharacteristic>
</statistic>
</Evidence>
IG © 2022+ HL7 International / Clinical Decision Support. Package hl7.fhir.uv.ebm#1.0.0-ballot based on FHIR 5.0.0. Generated 2023-12-17
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