Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot - ballot
Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot - ballot
This page is part of the Evidence Based Medicine on FHIR Implementation Guide (v1.0.0-ballot: STU1 Ballot 1) based on FHIR (HL7® FHIR® Standard) v5.0.0. . For a full list of available versions, see the Directory of published versions
| Active as of 2022-09-19 |
<Evidence xmlns="http://hl7.org/fhir">
<id value="104384"/>
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<lastUpdated value="2023-12-03T10:00:31.851Z"/>
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<profile
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<div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Evidence</b><a name="104384"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Evidence "104384" Version "13" Updated "2023-12-03 10:00:31+0000" </p><p style="margin-bottom: 0px">Profiles: <a href="StructureDefinition-comparator-only-evidence.html">ComparatorOnlyEvidence</a>, <a href="StructureDefinition-evidence-synthesis-evidence.html">EvidenceSynthesisEvidence</a></p></div><p><b>StructureDefinition Work Group</b>: cds</p><p><b>url</b>: <code>https://fevir.net/resources/Evidence/104384</code></p><p><b>identifier</b>: FEvIR Object Identifier: 104384</p><p><b>version</b>: 1.0.0-ballot</p><p><b>name</b>: AllCauseMortalityControlGroup2022metaAnalysis</p><p><b>title</b>: ComparatorOnlyEvidence: All-cause mortality without bariatric surgery in 2022 meta-analysis</p><p><b>status</b>: active</p><p><b>date</b>: 2022-09-19 21:15:10+0000</p><p><b>publisher</b>: HL7 International / Clinical Decision Support</p><p><b>contact</b>: HL7 International / Clinical Decision Support: <a href="http://www.hl7.org/Special/committees/dss">http://www.hl7.org/Special/committees/dss</a></p><p><b>author</b>: Brian S. Alper: </p><p><b>copyright</b>: https://creativecommons.org/licenses/by-nc-sa/4.0/</p><blockquote><p><b>relatedArtifact</b></p><p><b>type</b>: derived-from</p><p><b>label</b>: data source</p><p><b>citation</b>: Bariatric surgery and cardiovascular disease: a systematic review and meta-analysis [Journal Article]. Contributors: van Veldhuisen SL, Gorter TM, van Woerden G, de Boer RA, Rienstra M, Hazebroek EJ, van Veldhuisen DJ. In: European heart journal, PMID 35243488. Published March 04, 2022. Available at: https://pubmed.ncbi.nlm.nih.gov/35243488/.</p><blockquote><p><b>document</b></p></blockquote></blockquote><blockquote><p><b>relatedArtifact</b></p><p><b>type</b>: supported-with</p><p><b>classifier</b>: Citation Resource for the original article <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><p><b>display</b>: Citation Resource for 2022 Systematic Review of bariatric surgery mortality effect - PMID 35243488</p><p><b>resourceReference</b>: <a href="Citation-33400.html">Citation/33400: StudyCitation: 2022 Systematic Review of bariatric surgery mortality effect 35243488</a></p></blockquote><blockquote><p><b>relatedArtifact</b></p><p><b>type</b>: cite-as</p><p><b>citation</b>: ComparatorOnlyEvidence: All-cause mortality without bariatric surgery in 2022 meta-analysis [Evidence]. Contributors: Brian S. Alper [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 104384. Revised 2022-09-19. Available at: https://fevir.net/resources/Evidence/104384. Computable resource at: https://fevir.net/resources/Evidence/104384.</p></blockquote><p><b>description</b>: estimate for all-cause mortality without bariatric surgery 4.75% based on median control event rate in 26 cohort studies with post-bariatric surgery patients and obese controls</p><blockquote><p><b>variableDefinition</b></p><p><b>VariableDefinitionVariableRoleCode</b>: population</p><p><b>description</b>: obese, adult (age ≥18 years old) patients who had No weight-loss surgical intervention *NOTE: note.text is used artificially to support the EBMonFHIR Implementation Guide and the following content would more properly be found in a note.text element:* Studies were considered eligible if they were designed to study outcomes in obese patients who underwent a weight-loss surgical intervention in comparison with an age, sex, and BMI matched control group who did not undergo a weight-loss surgical intervention. We searched for randomized controlled trials, prospective or retrospective longitudinal cohort studies, and case–control studies. For the control group, all non-surgical treatment options for obesity (e.g. intensive lifestyle intervention, standard of care, or no specific therapy) were accepted. Studies were excluded if (i) patients were not matched for age, sex, and BMI; (ii) the presence of one or more outcome parameters of interest (e.g. HF, AF, coronary artery disease) was required for inclusion; or (iii) if study groups were not representative in relation to the general population of patients with obesity (e.g. patients could only be included in the presence of a specific comorbidity, for instance, end-stage renal disease). The third criterium did not apply to Type 2 diabetes, thus studies that only included patients with Type 2 diabetes could be eligible for inclusion. As the control group (observed reference exposure) was defined differently in each study, the intended reference exposure is described as the absence of the intended exposure (Bariatric Surgery).</p><p><b>note</b>: population</p><p><b>variableRole</b>: Use extension:variableRoleCode instead. <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-variable-role.html">EvidenceVariableRole</a>#population "population")</span></p><p><b>intended</b>: <a href="Group-172460.html">Group/172460: ComparatorGroup: Obese patients ≥ 18 years old without bariatric surgery</a> "ComparatorGroup_Obese_patients_18_years_old_without_bariatric_surgery"</p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>VariableDefinitionVariableRoleCode</b>: outcome</p><p><b>description</b>: All-cause mortality *NOTE: note.text is used artificially to support the EBMonFHIR Implementation Guide and the following content would more properly be found in a note.text element:* The observed element can reference an EvidenceVariable Resource that defines the outcome measured through structured characteristics. For example, 'Mean difference in HbA1c at 12 months' or 'Mean difference in HbA1c at end of study'. The structured characteristics can be references to the Evidence instances for each of the included studies, in which case this is a direct link to the dataset used for analysis. The intended element can reference an EvidenceVariable Resource that expresses the outcome intended for evidence application through structured characteristics. The structured characteristics could be used to express the SR eligibility criteria for study outcomes (as a subset of eligibility criteria for studies).</p><p><b>note</b>: outcome</p><p><b>variableRole</b>: Use extension:variableRoleCode instead. <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-variable-role.html">EvidenceVariableRole</a>#measuredVariable "measured variable")</span></p><p><b>observed</b>: <span>: We searched for randomized controlled trials, prospective or retrospective longitudinal cohort studies, and case–control studies. For the control group, all non-surgical treatment options for obesity (e.g. intensive lifestyle intervention, standard of care, or no specific therapy) were accepted. Studies were excluded if (i) patients were not matched for age, sex, and BMI; (ii) the presence of one or more outcome parameters of interest (e.g. HF, AF, coronary artery disease) was required for inclusion; or (iii) if study groups were not representative in relation to the general population of patients with obesity (e.g. patients could only be included in the presence of a specific comorbidity, for instance, end-stage renal disease). The third criterium did not apply to Type 2 diabetes, thus studies that only included patients with Type 2 diabetes could be eligible for inclusion.</span></p><p><b>intended</b>: <a href="EvidenceVariable-49217.html">EvidenceVariable/49217: OutcomeVariable: All-cause mortality</a> "OutcomeVariable_All_cause_mortality"</p></blockquote><p><b>synthesisType</b>: median of pooled rates <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-synthesis-type.html">StatisticSynthesisType</a>#pooled "pooled rates")</span></p><p><b>studyDesign</b>: Observational research <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/R5/codesystem-study-design.html">Study Design[5.0.0-cibuild]</a>#SEVCO:01002)</span>, Parallel cohort design <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/R5/codesystem-study-design.html">Study Design[5.0.0-cibuild]</a>#SEVCO:01011)</span>, Matching for comparison <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/R5/codesystem-study-design.html">Study Design[5.0.0-cibuild]</a>#SEVCO:01014)</span></p><blockquote><p><b>statistic</b></p><p><b>description</b>: median pooled rate 4.75% (range 1.4% to 28.2%) among 26 studies with control event rates</p><p><b>statisticType</b>: Proportion <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (StatisticStatisticType[5.0.0-cibuild]#C44256)</span></p><p><b>quantity</b>: 0.0475</p><h3>SampleSizes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>NumberOfStudies</b></td></tr><tr><td style="display: none">*</td><td>26</td></tr></table><h3>AttributeEstimates</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Description</b></td><td><b>Type</b></td><td><b>Range</b></td></tr><tr><td style="display: none">*</td><td>range 1.4% to 28.2%</td><td>Range <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (StatisticAttribute Estimate Type[5.0.0-cibuild]#C38013)</span></td><td>0.014-0.282</td></tr></table><h3>ModelCharacteristics</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td></tr><tr><td style="display: none">*</td><td>median value of proportions <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-179423.html">Evidence Based Medicine on FHIR Implementation Guide Code System</a>#defined-in-text "Defined in text")</span></td></tr></table></blockquote></div>
</text>
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<name value="AllCauseMortalityControlGroup2022metaAnalysis"/>
<title
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<status value="active"/>
<date value="2022-09-19T21:15:10.416Z"/>
<publisher value="HL7 International / Clinical Decision Support"/>
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<citation
value="Bariatric surgery and cardiovascular disease: a systematic review and meta-analysis [Journal Article]. Contributors: van Veldhuisen SL, Gorter TM, van Woerden G, de Boer RA, Rienstra M, Hazebroek EJ, van Veldhuisen DJ. In: European heart journal, PMID 35243488. Published March 04, 2022. Available at: https://pubmed.ncbi.nlm.nih.gov/35243488/."/>
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<citation
value="ComparatorOnlyEvidence: All-cause mortality without bariatric surgery in 2022 meta-analysis [Evidence]. Contributors: Brian S. Alper [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 104384. Revised 2022-09-19. Available at: https://fevir.net/resources/Evidence/104384. Computable resource at: https://fevir.net/resources/Evidence/104384."/>
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<description
value="estimate for all-cause mortality without bariatric surgery 4.75% based on median control event rate in 26 cohort studies with post-bariatric surgery patients and obese controls"/>
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<description
value="obese, adult (age ≥18 years old) patients who had No weight-loss surgical intervention *NOTE: note.text is used artificially to support the EBMonFHIR Implementation Guide and the following content would more properly be found in a note.text element:* Studies were considered eligible if they were designed to study outcomes in obese patients who underwent a weight-loss surgical intervention in comparison with an age, sex, and BMI matched control group who did not undergo a weight-loss surgical intervention. We searched for randomized controlled trials, prospective or retrospective longitudinal cohort studies, and case–control studies. For the control group, all non-surgical treatment options for obesity (e.g. intensive lifestyle intervention, standard of care, or no specific therapy) were accepted. Studies were excluded if (i) patients were not matched for age, sex, and BMI; (ii) the presence of one or more outcome parameters of interest (e.g. HF, AF, coronary artery disease) was required for inclusion; or (iii) if study groups were not representative in relation to the general population of patients with obesity (e.g. patients could only be included in the presence of a specific comorbidity, for instance, end-stage renal disease). The third criterium did not apply to Type 2 diabetes, thus studies that only included patients with Type 2 diabetes could be eligible for inclusion. As the control group (observed reference exposure) was defined differently in each study, the intended reference exposure is described as the absence of the intended exposure (Bariatric Surgery)."/>
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<text value="Use extension:variableRoleCode instead."/>
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<intended>🔗
<reference value="Group/172460"/>
<type value="Group"/>
<display
value="ComparatorGroup: Obese patients ≥ 18 years old without bariatric surgery"/>
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<variableDefinition>
<extension
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<valueCode value="outcome"/>
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<description
value="All-cause mortality *NOTE: note.text is used artificially to support the EBMonFHIR Implementation Guide and the following content would more properly be found in a note.text element:* The observed element can reference an EvidenceVariable Resource that defines the outcome measured through structured characteristics. For example, 'Mean difference in HbA1c at 12 months' or 'Mean difference in HbA1c at end of study'. The structured characteristics can be references to the Evidence instances for each of the included studies, in which case this is a direct link to the dataset used for analysis. The intended element can reference an EvidenceVariable Resource that expresses the outcome intended for evidence application through structured characteristics. The structured characteristics could be used to express the SR eligibility criteria for study outcomes (as a subset of eligibility criteria for studies)."/>
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<variableRole>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/variable-role"/>
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<display value="measured variable"/>
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<text value="Use extension:variableRoleCode instead."/>
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value="We searched for randomized controlled trials, prospective or retrospective longitudinal cohort studies, and case–control studies. For the control group, all non-surgical treatment options for obesity (e.g. intensive lifestyle intervention, standard of care, or no specific therapy) were accepted. Studies were excluded if (i) patients were not matched for age, sex, and BMI; (ii) the presence of one or more outcome parameters of interest (e.g. HF, AF, coronary artery disease) was required for inclusion; or (iii) if study groups were not representative in relation to the general population of patients with obesity (e.g. patients could only be included in the presence of a specific comorbidity, for instance, end-stage renal disease). The third criterium did not apply to Type 2 diabetes, thus studies that only included patients with Type 2 diabetes could be eligible for inclusion."/>
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<intended>🔗
<reference value="EvidenceVariable/49217"/>
<type value="EvidenceVariable"/>
<display value="OutcomeVariable: All-cause mortality"/>
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<studyDesign>
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<version value="5.0.0-cibuild"/>
<code value="SEVCO:01002"/>
<display value="Observational research"/>
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<studyDesign>
<coding>
<system value="http://hl7.org/fhir/study-design"/>
<version value="5.0.0-cibuild"/>
<code value="SEVCO:01011"/>
<display value="Parallel cohort design"/>
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<studyDesign>
<coding>
<system value="http://hl7.org/fhir/study-design"/>
<version value="5.0.0-cibuild"/>
<code value="SEVCO:01014"/>
<display value="Matching for comparison"/>
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<statistic>
<description
value="median pooled rate 4.75% (range 1.4% to 28.2%) among 26 studies with control event rates"/>
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<version value="5.0.0-cibuild"/>
<code value="C44256"/>
<display value="Proportion"/>
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<quantity>
<value value="0.0475"/>
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<sampleSize>
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<description value="range 1.4% to 28.2%"/>
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<version value="5.0.0-cibuild"/>
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<display value="Range"/>
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<range>
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<high>
<value value="0.282"/>
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<modelCharacteristic>
<code>
<coding>
<system value="https://fevir.net/resources/CodeSystem/179423"/>
<code value="defined-in-text"/>
<display value="Defined in text"/>
</coding>
<text value="median value of proportions"/>
</code>
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</Evidence>
IG © 2022+ HL7 International / Clinical Decision Support. Package hl7.fhir.uv.ebm#1.0.0-ballot based on FHIR 5.0.0. Generated 2023-12-17
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