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identifier: FEvIR Object Identifier: 33400, id: 35243488

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title: StudyCitation: 2022 Systematic Review of bariatric surgery mortality effect 35243488

status: active

date: 2022-05-28 12:27:14+0000

publisher: HL7 International / Clinical Decision Support

contact: HL7 International / Clinical Decision Support: http://www.hl7.org/Special/committees/dss

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lastReviewDate: 2022-03-10

author: Brian S. Alper:

Summaries

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identifier: id: 35243488, id: PMC9123239, id: 10.1093/eurheartj/ehac071, pii: 6542137

Titles

-	Type	Language	Text
*	Primary title (Title Type#primary)	English (Tags for the Identification of Languages#en)	Bariatric surgery and cardiovascular disease: a systematic review and meta-analysis.

Abstracts

-	Text	Copyright
*	**AIMS:** Obesity is a global health problem, associated with significant morbidity and mortality, often due to cardiovascular (CV) diseases. While bariatric surgery is increasingly performed in patients with obesity and reduces CV risk factors, its effect on CV disease is not established. We conducted a systematic review and meta-analysis to evaluate the effect of bariatric surgery on CV outcomes, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline. **METHODS AND RESULTS:** PubMed and Embase were searched for literature until August 2021 which compared bariatric surgery patients to non-surgical controls. Outcomes of interest were all-cause and CV mortality, atrial fibrillation (AF), heart failure (HF), myocardial infarction, and stroke. We included 39 studies, all prospective or retrospective cohort studies, but randomized outcome trials were not available. Bariatric surgery was associated with a beneficial effect on all-cause mortality [pooled hazard ratio (HR) of 0.55; 95% confidence interval (CI) 0.49-0.62, P < 0.001 vs. controls], and CV mortality (HR 0.59, 95% CI 0.47-0.73, P < 0.001). In addition, bariatric surgery was also associated with a reduced incidence of HF (HR 0.50, 95% CI 0.38-0.66, P < 0.001), myocardial infarction (HR 0.58, 95% CI 0.43-0.76, P < 0.001), and stroke (HR 0.64, 95% CI 0.53-0.77, P < 0.001), while its association with AF was not statistically significant (HR 0.82, 95% CI 0.64-1.06, P = 0.12). **CONCLUSION:** The present systematic review and meta-analysis suggests that bariatric surgery is associated with reduced all-cause and CV mortality, and lowered incidence of several CV diseases in patients with obesity. Bariatric surgery should therefore be considered in these patients.	© The Author(s) 2022. Published by Oxford University Press on behalf of European Society of Cardiology.

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affiliation: : Department of Cardiology, University of Groningen, University Medical Centre Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.

Generated Narrative: ArtifactAssessment #keywords0

artifact: Citation/33399

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classifier: Atrial fibrillation ()

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classifier: Bariatric surgery ()

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classifier: Cardiovascular disease ()

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classifier: Heart failure ()

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classifier: Metabolic surgery ()

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classifier: Myocardial infarction ()

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classifier: Obesity ()

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classifier: Outcome ()

Generated Narrative: Practitioner #author0

identifier: ORCID: 0000-0002-0044-8441

name: Sophie L van Veldhuisen

Generated Narrative: ArtifactAssessment #meshHeading0

artifact: #

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informationType: classifier

type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")

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freeToShare: true

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classifier: complications (#Q000150)

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type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")

classifier: Bariatric Surgery (#D050110)

freeToShare: true

component

type: qualifier ()

classifier: is Major topic ()

component

type: qualifier ()

classifier: adverse effects (#Q000009)

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content

informationType: classifier

type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")

classifier: Cardiovascular Diseases (#D002318)

freeToShare: true

component

type: qualifier ()

classifier: is Major topic ()

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classifier: etiology (#Q000209)

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type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")

classifier: Heart Failure (#D006333)

freeToShare: true

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classifier: is Major topic ()

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type: qualifier ()

classifier: complications (#Q000150)

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informationType: classifier

type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")

classifier: Humans (#D006801)

freeToShare: true

Components

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*	qualifier ()	is not a major topic ()

content

informationType: classifier

type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")

classifier: Myocardial Infarction (#D009203)

freeToShare: true

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freeToShare: true

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classifier: Prospective Studies (#D011446)

freeToShare: true

Components

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content

informationType: classifier

type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")

classifier: Retrospective Studies (#D012189)

freeToShare: true

Components

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content

informationType: classifier

type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")

classifier: Stroke (#D020521)

freeToShare: true

component

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classifier: is Major topic ()

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type: qualifier ()

classifier: complications (#Q000150)

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Generated Narrative: Practitioner #author1

identifier: ORCID: 0000-0001-5000-8359

name: Thomas M Gorter

Generated Narrative: Practitioner #author2

identifier: ORCID: 0000-0001-7907-2944

name: Gijs van Woerden

Generated Narrative: Practitioner #author3

name: Rudolf A de Boer

Generated Narrative: Practitioner #author4

identifier: ORCID: 0000-0002-2581-070X

name: Michiel Rienstra

Generated Narrative: Practitioner #author5

identifier: ORCID: 0000-0001-5458-3334

name: Eric J Hazebroek

Generated Narrative: Practitioner #author6

name: Dirk J van Veldhuisen

Generated Narrative: Practitioner #contributor0

identifier: ORCID: 0000-0002-0044-8441

name: Sophie L van Veldhuisen

Generated Narrative: Practitioner #contributor1

identifier: ORCID: 0000-0001-5000-8359

name: Thomas M Gorter

Generated Narrative: Practitioner #contributor2

identifier: ORCID: 0000-0001-7907-2944

name: Gijs van Woerden

Generated Narrative: Practitioner #contributor3

name: Rudolf A de Boer

Generated Narrative: Practitioner #contributor4

identifier: ORCID: 0000-0002-2581-070X

name: Michiel Rienstra

Generated Narrative: Practitioner #contributor5

identifier: ORCID: 0000-0001-5458-3334

name: Eric J Hazebroek

Generated Narrative: Practitioner #contributor6

name: Dirk J van Veldhuisen