Risk of fatal ICH without alteplase for stroke

{
  "resourceType" : "Evidence",
  "id" : "example-stroke-no-alteplase-fatalICH",
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n      \n      <p>\n        &quot;Risk of fatal ICH without alteplase for stroke&quot; is a univariate risk estimate.\n      </p>\n\t\n    </div>"
  },
  "url" : "http://hl7.org/fhir/Evidence/example-stroke-no-alteplase-fatalICH",
  "identifier" : [{
    "system" : "urn:ietf:rfc:3986",
    "value" : "urn:oid:2.16.840.1.113883.4.642.10.4"
  }],
  "name" : "RiskOfFatalICHWithoutAlteplaseForStroke",
  "title" : "Risk of fatal ICH without alteplase for stroke",
  "status" : "draft",
  "relatedArtifact" : [{
    "type" : "citation",
    "label" : "Emberson 2014",
    "display" : "Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials.",
    "citation" : "Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, et al;Stroke Thrombolysis Trialists' Collaborative Group. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet 2014 Nov 29;384(9958):1929-35 PMID 25106063",
    "document" : {
      "url" : "https://doi.org/10.1016/S0140-6736(14)60584-5"
    }
  }],
  "description" : "0.4% incidence of fatal intracranial hemorrhage within 7 days without alteplase in patients with acute ischemic stroke",
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    },
    "observed" : {
      "reference" : "Group/AcuteIschemicStroke",
      "type" : "Group",
      "display" : "adults with acute ischemic stroke"
    },
    "intended" : {
      "reference" : "Group/AcuteIschemicStroke",
      "type" : "Group",
      "display" : "adults with acute ischemic stroke"
    }
  },
  {
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    },
    "observed" : {
      "reference" : "Group/Emberson-2014-IPD-MA-No-Alteplase-Cohort",
      "type" : "Group",
      "display" : "Emberson 2014 IPD-MA No Alteplase Cohort"
    },
    "intended" : {
      "reference" : "Group/AcuteIschemicStrokeTreatedWithoutAlteplase",
      "type" : "Group",
      "display" : "adults with acute ischemic stroke treated without alteplase"
    }
  },
  {
    "variableRole" : {
      "coding" : [{
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        "code" : "measuredVariable",
        "display" : "measured variable"
      }]
    },
    "observed" : {
      "reference" : "EvidenceVariable/example-fatal-ICH-in-7-days",
      "type" : "EvidenceVariable",
      "display" : "fatal ICH"
    },
    "intended" : {
      "reference" : "EvidenceVariable/example-fatal-ICH-in-7-days",
      "type" : "EvidenceVariable",
      "display" : "fatal ICH"
    }
  }],
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    "coding" : [{
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    }]
  },
  "studyDesign" : [{
    "coding" : [{
      "system" : "http://hl7.org/fhir/study-design",
      "code" : "SEVCO:01003",
      "display" : "randomized assignment"
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  }],
  "statistic" : [{
    "statisticType" : {
      "coding" : [{
        "system" : "http://terminology.hl7.org/CodeSystem/statistic-type",
        "code" : "C44256",
        "display" : "Proportion"
      }]
    },
    "quantity" : {
      "value" : 0.00386298627
    },
    "numberOfEvents" : 13,
    "sampleSize" : {
      "numberOfStudies" : 9,
      "numberOfParticipants" : 3365
    }
  }]
}