{"description":"0.4% incidence of fatal intracranial hemorrhage within 7 days without alteplase in patients with acute ischemic stroke","id":"example-stroke-no-alteplase-fatalICH","identifier":[{"system":"urn:ietf:rfc:3986","value":"urn:oid:2.16.840.1.113883.4.642.10.4"}],"name":"RiskOfFatalICHWithoutAlteplaseForStroke","relatedArtifact":[{"citation":"Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, et al;Stroke Thrombolysis Trialists' Collaborative Group. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet 2014 Nov 29;384(9958):1929-35 PMID 25106063","display":"Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials.","document":{"url":"https://doi.org/10.1016/S0140-6736(14)60584-5"},"label":"Emberson 2014","type":"citation"}],"resourceType":"Evidence","statistic":[{"numberOfEvents":13,"quantity":{"value":0.00386298627},"sampleSize":{"numberOfParticipants":3365,"numberOfStudies":9},"statisticType":{"coding":[{"code":"C44256","display":"Proportion","system":"http://terminology.hl7.org/CodeSystem/statistic-type"}]}}],"status":"draft","studyDesign":[{"coding":[{"code":"SEVCO:01003","display":"randomized assignment","system":"http://hl7.org/fhir/study-design"}]}],"synthesisType":{"coding":[{"code":"IPD-MA","display":"individual patient data meta-analysis","system":"http://terminology.hl7.org/CodeSystem/synthesis-type"}]},"text":{"div":"<div xmlns=\"http://www.w3.org/1999/xhtml\">\n      \n      <p>\n        &quot;Risk of fatal ICH without alteplase for stroke&quot; is a univariate risk estimate.\n      </p>\n\t\n    </div>","status":"generated"},"title":"Risk of fatal ICH without alteplase for stroke","url":"http://hl7.org/fhir/Evidence/example-stroke-no-alteplase-fatalICH","variableDefinition":[{"intended":{"display":"adults with acute ischemic stroke","reference":"Group/AcuteIschemicStroke","type":"Group"},"observed":{"display":"adults with acute ischemic stroke","reference":"Group/AcuteIschemicStroke","type":"Group"},"variableRole":{"coding":[{"code":"population","display":"population","system":"http://terminology.hl7.org/CodeSystem/variable-role"}]}},{"intended":{"display":"adults with acute ischemic stroke treated without alteplase","reference":"Group/AcuteIschemicStrokeTreatedWithoutAlteplase","type":"Group"},"observed":{"display":"Emberson 2014 IPD-MA No Alteplase Cohort","reference":"Group/Emberson-2014-IPD-MA-No-Alteplase-Cohort","type":"Group"},"variableRole":{"coding":[{"code":"population","display":"population","system":"http://terminology.hl7.org/CodeSystem/variable-role"}]}},{"intended":{"display":"fatal ICH","reference":"EvidenceVariable/example-fatal-ICH-in-7-days","type":"EvidenceVariable"},"observed":{"display":"fatal ICH","reference":"EvidenceVariable/example-fatal-ICH-in-7-days","type":"EvidenceVariable"},"variableRole":{"coding":[{"code":"measuredVariable","display":"measured variable","system":"http://terminology.hl7.org/CodeSystem/variable-role"}]}}]}