15.9 Resource SubstanceDefinition - Content

<SubstanceDefinition xmlns="http://hl7.org/fhir"> 
 <!-- from Resource: id, meta, implicitRules, and language -->
 <!-- from DomainResource: text, contained, extension, and modifierExtension -->
 <identifier><!-- 0..* Identifier Identifier by which this substance is known --></identifier>
 <version value="[string]"/><!-- 0..1 A business level version identifier of the substance -->
 <status><!-- 0..1 CodeableConcept Status of substance within the catalogue e.g. active, retired --></status>
 <classification><!-- 0..* CodeableConcept A categorization, high level e.g. polymer or nucleic acid, or food, chemical, biological, or lower e.g. polymer linear or branch chain, or type of impurity --></classification>
 <domain><!-- 0..1 CodeableConcept If the substance applies to human or veterinary use --></domain>
 <grade><!-- 0..* CodeableConcept The quality standard, established benchmark, to which substance complies (e.g. USP/NF, BP) --></grade>
 <description value="[markdown]"/><!-- 0..1 Textual description of the substance -->
 <informationSource><!-- 0..* Reference(Citation) Supporting literature --></informationSource>
 <note><!-- 0..* Annotation Textual comment about the substance's catalogue or registry record --></note>
 <manufacturer><!-- 0..* Reference(Organization) The entity that creates, makes, produces or fabricates the substance --></manufacturer>
 <supplier><!-- 0..* Reference(Organization) An entity that is the source for the substance. It may be different from the manufacturer --></supplier>
 <moiety>  <!-- 0..* Moiety, for structural modifications -->
  <role><!-- 0..1 CodeableConcept Role that the moiety is playing --></role>
  <identifier><!-- 0..1 Identifier Identifier by which this moiety substance is known --></identifier>
  <name value="[string]"/><!-- 0..1 Textual name for this moiety substance -->
  <stereochemistry><!-- 0..1 CodeableConcept Stereochemistry type --></stereochemistry>
  <opticalActivity><!-- 0..1 CodeableConcept Optical activity type --></opticalActivity>
  <molecularFormula value="[string]"/><!-- 0..1 Molecular formula for this moiety (e.g. with the Hill system) -->
  <amount[x]><!-- 0..1 Quantity|string Quantitative value for this moiety --></amount[x]>
  <measurementType><!-- 0..1 CodeableConcept The measurement type of the quantitative value --></measurementType>
 </moiety>
 <property>  <!-- 0..* General specifications for this substance -->
  <type><!-- 1..1 CodeableConcept A code expressing the type of property  --></type>
  <value[x]><!-- 0..1 CodeableConcept|Quantity|date|boolean|Attachment A value for the property --></value[x]>
 </property>
 <molecularWeight>  <!-- 0..* The molecular weight or weight range -->
  <method><!-- 0..1 CodeableConcept The method by which the weight was determined --></method>
  <type><!-- 0..1 CodeableConcept Type of molecular weight e.g. exact, average, weight average --></type>
  <amount><!-- 1..1 Quantity Used to capture quantitative values for a variety of elements --></amount>
 </molecularWeight>
 <structure>  <!-- 0..1 Structural information -->
  <stereochemistry><!-- 0..1 CodeableConcept Stereochemistry type --></stereochemistry>
  <opticalActivity><!-- 0..1 CodeableConcept Optical activity type --></opticalActivity>
  <molecularFormula value="[string]"/><!-- 0..1 Molecular formula (e.g. using the Hill system) -->
  <molecularFormulaByMoiety value="[string]"/><!-- 0..1 Specified per moiety according to the Hill system -->
  <molecularWeight><!-- 0..1 Content as for SubstanceDefinition.molecularWeight The molecular weight or weight range --></molecularWeight>
  <technique><!-- 0..* CodeableConcept The method used to find the structure e.g. X-ray, NMR --></technique>
  <sourceDocument><!-- 0..* Reference(DocumentReference) Source of information for the structure --></sourceDocument>
  <representation>  <!-- 0..* A depiction of the structure or characterization of the substance -->
   <type><!-- 0..1 CodeableConcept The kind of structural representation (e.g. full, partial) --></type>
   <representation value="[string]"/><!-- 0..1 The structural representation or characterization as a text string in a standard format -->
   <format><!-- 0..1 CodeableConcept The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format) --></format>
   <document><!-- 0..1 Reference(DocumentReference) An attachment with the structural representation e.g. a structure graphic or AnIML file --></document>
  </representation>
 </structure>
 <code>  <!-- 0..* Codes associated with the substance -->
  <code><!-- 0..1 CodeableConcept The specific code --></code>
  <status><!-- 0..1 CodeableConcept Status of the code assignment, for example 'provisional', 'approved' --></status>
  <statusDate value="[dateTime]"/><!-- 0..1 The date at which the code status was changed -->
  <note><!-- 0..* Annotation Any comment can be provided in this field --></note>
  <source><!-- 0..* Reference(DocumentReference) Supporting literature --></source>
 </code>
 <name>  <!-- 0..* Names applicable to this substance -->
  <name value="[string]"/><!-- 1..1 The actual name -->
  <type><!-- 0..1 CodeableConcept Name type e.g. 'systematic',  'scientific, 'brand' --></type>
  <status><!-- 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed' --></status>
  <preferred value="[boolean]"/><!-- 0..1 If this is the preferred name for this substance -->
  <language><!-- 0..* CodeableConcept Human language that the name is written in --></language>
  <domain><!-- 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive --></domain>
  <jurisdiction><!-- 0..* CodeableConcept The jurisdiction where this name applies --></jurisdiction>
  <synonym><!-- 0..* Content as for SubstanceDefinition.name A synonym of this particular name, by which the substance is also known --></synonym>
  <translation><!-- 0..* Content as for SubstanceDefinition.name A translation for this name into another human language --></translation>
  <official>  <!-- 0..* Details of the official nature of this name -->
   <authority><!-- 0..1 CodeableConcept Which authority uses this official name --></authority>
   <status><!-- 0..1 CodeableConcept The status of the official name, for example 'draft', 'active' --></status>
   <date value="[dateTime]"/><!-- 0..1 Date of official name change -->
  </official>
  <source><!-- 0..* Reference(DocumentReference) Supporting literature --></source>
 </name>
 <relationship>  <!-- 0..* A link between this substance and another -->
  <substanceDefinition[x]><!-- 0..1 Reference(SubstanceDefinition)|
    CodeableConcept A pointer to another substance, as a resource or a representational code --></substanceDefinition[x]>
  <type><!-- 1..1 CodeableConcept For example "salt to parent", "active moiety" --></type>
  <isDefining value="[boolean]"/><!-- 0..1 For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships -->
  <amount[x]><!-- 0..1 Quantity|Ratio|string A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other --></amount[x]>
  <ratioHighLimitAmount><!-- 0..1 Ratio For use when the numeric has an uncertain range --></ratioHighLimitAmount>
  <comparator><!-- 0..1 CodeableConcept An operator for the amount, for example "average", "approximately", "less than" --></comparator>
  <source><!-- 0..* Reference(DocumentReference) Supporting literature --></source>
 </relationship>
 <sourceMaterial>  <!-- 0..1 Material or taxonomic/anatomical source -->
  <type><!-- 0..1 CodeableConcept Classification of the origin of the raw material. e.g. cat hair is an Animal source type --></type>
  <genus><!-- 0..1 CodeableConcept The genus of an organism e.g. the Latin epithet of the plant/animal scientific name --></genus>
  <species><!-- 0..1 CodeableConcept The species of an organism e.g. the Latin epithet of the species of the plant/animal --></species>
  <part><!-- 0..1 CodeableConcept An anatomical origin of the source material within an organism --></part>
  <countryOfOrigin><!-- 0..* CodeableConcept The country or countries where the material is harvested --></countryOfOrigin>
 </sourceMaterial>
</SubstanceDefinition>

{
  "resourceType" : "SubstanceDefinition",
  // from Resource: id, meta, implicitRules, and language
  // from DomainResource: text, contained, extension, and modifierExtension
  "identifier" : [{ Identifier }], // Identifier by which this substance is known
  "version" : "<string>", // A business level version identifier of the substance
  "status" : { CodeableConcept }, // Status of substance within the catalogue e.g. active, retired
  "classification" : [{ CodeableConcept }], // A categorization, high level e.g. polymer or nucleic acid, or food, chemical, biological, or lower e.g. polymer linear or branch chain, or type of impurity
  "domain" : { CodeableConcept }, // If the substance applies to human or veterinary use
  "grade" : [{ CodeableConcept }], // The quality standard, established benchmark, to which substance complies (e.g. USP/NF, BP)
  "description" : "<markdown>", // Textual description of the substance
  "informationSource" : [{ Reference(Citation) }], // Supporting literature
  "note" : [{ Annotation }], // Textual comment about the substance's catalogue or registry record
  "manufacturer" : [{ Reference(Organization) }], // The entity that creates, makes, produces or fabricates the substance
  "supplier" : [{ Reference(Organization) }], // An entity that is the source for the substance. It may be different from the manufacturer
  "moiety" : [{ // Moiety, for structural modifications
    "role" : { CodeableConcept }, // Role that the moiety is playing
    "identifier" : { Identifier }, // Identifier by which this moiety substance is known
    "name" : "<string>", // Textual name for this moiety substance
    "stereochemistry" : { CodeableConcept }, // Stereochemistry type
    "opticalActivity" : { CodeableConcept }, // Optical activity type
    "molecularFormula" : "<string>", // Molecular formula for this moiety (e.g. with the Hill system)
    // amount[x]: Quantitative value for this moiety. One of these 2:
    "amountQuantity" : { Quantity },
    "amountString" : "<string>",
    "measurementType" : { CodeableConcept } // The measurement type of the quantitative value
  }],
  "property" : [{ // General specifications for this substance
    "type" : { CodeableConcept }, // R!  A code expressing the type of property 
    // value[x]: A value for the property. One of these 5:
    "valueCodeableConcept" : { CodeableConcept }
    "valueQuantity" : { Quantity }
    "valueDate" : "<date>"
    "valueBoolean" : <boolean>
    "valueAttachment" : { Attachment }
  }],
  "molecularWeight" : [{ // The molecular weight or weight range
    "method" : { CodeableConcept }, // The method by which the weight was determined
    "type" : { CodeableConcept }, // Type of molecular weight e.g. exact, average, weight average
    "amount" : { Quantity } // R!  Used to capture quantitative values for a variety of elements
  }],
  "structure" : { // Structural information
    "stereochemistry" : { CodeableConcept }, // Stereochemistry type
    "opticalActivity" : { CodeableConcept }, // Optical activity type
    "molecularFormula" : "<string>", // Molecular formula (e.g. using the Hill system)
    "molecularFormulaByMoiety" : "<string>", // Specified per moiety according to the Hill system
    "molecularWeight" : { Content as for SubstanceDefinition.molecularWeight }, // The molecular weight or weight range
    "technique" : [{ CodeableConcept }], // The method used to find the structure e.g. X-ray, NMR
    "sourceDocument" : [{ Reference(DocumentReference) }], // Source of information for the structure
    "representation" : [{ // A depiction of the structure or characterization of the substance
      "type" : { CodeableConcept }, // The kind of structural representation (e.g. full, partial)
      "representation" : "<string>", // The structural representation or characterization as a text string in a standard format
      "format" : { CodeableConcept }, // The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format)
      "document" : { Reference(DocumentReference) } // An attachment with the structural representation e.g. a structure graphic or AnIML file
    }]
  },
  "code" : [{ // Codes associated with the substance
    "code" : { CodeableConcept }, // The specific code
    "status" : { CodeableConcept }, // Status of the code assignment, for example 'provisional', 'approved'
    "statusDate" : "<dateTime>", // The date at which the code status was changed
    "note" : [{ Annotation }], // Any comment can be provided in this field
    "source" : [{ Reference(DocumentReference) }] // Supporting literature
  }],
  "name" : [{ // Names applicable to this substance
    "name" : "<string>", // R!  The actual name
    "type" : { CodeableConcept }, // Name type e.g. 'systematic',  'scientific, 'brand'
    "status" : { CodeableConcept }, // The status of the name e.g. 'current', 'proposed'
    "preferred" : <boolean>, // If this is the preferred name for this substance
    "language" : [{ CodeableConcept }], // Human language that the name is written in
    "domain" : [{ CodeableConcept }], // The use context of this name e.g. as an active ingredient or as a food colour additive
    "jurisdiction" : [{ CodeableConcept }], // The jurisdiction where this name applies
    "synonym" : [{ Content as for SubstanceDefinition.name }], // A synonym of this particular name, by which the substance is also known
    "translation" : [{ Content as for SubstanceDefinition.name }], // A translation for this name into another human language
    "official" : [{ // Details of the official nature of this name
      "authority" : { CodeableConcept }, // Which authority uses this official name
      "status" : { CodeableConcept }, // The status of the official name, for example 'draft', 'active'
      "date" : "<dateTime>" // Date of official name change
    }],
    "source" : [{ Reference(DocumentReference) }] // Supporting literature
  }],
  "relationship" : [{ // A link between this substance and another
    // substanceDefinition[x]: A pointer to another substance, as a resource or a representational code. One of these 2:
    "substanceDefinitionReference" : { Reference(SubstanceDefinition) },
    "substanceDefinitionCodeableConcept" : { CodeableConcept },
    "type" : { CodeableConcept }, // R!  For example "salt to parent", "active moiety"
    "isDefining" : <boolean>, // For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships
    // amount[x]: 
      A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other. One of these 3:
    "amountQuantity" : { Quantity },
    "amountRatio" : { Ratio },
    "amountString" : "<string>",
    "ratioHighLimitAmount" : { Ratio }, // For use when the numeric has an uncertain range
    "comparator" : { CodeableConcept }, // An operator for the amount, for example "average", "approximately", "less than"
    "source" : [{ Reference(DocumentReference) }] // Supporting literature
  }],
  "sourceMaterial" : { // Material or taxonomic/anatomical source
    "type" : { CodeableConcept }, // Classification of the origin of the raw material. e.g. cat hair is an Animal source type
    "genus" : { CodeableConcept }, // The genus of an organism e.g. the Latin epithet of the plant/animal scientific name
    "species" : { CodeableConcept }, // The species of an organism e.g. the Latin epithet of the species of the plant/animal
    "part" : { CodeableConcept }, // An anatomical origin of the source material within an organism
    "countryOfOrigin" : [{ CodeableConcept }] // The country or countries where the material is harvested
  }
}

@prefix fhir: <http://hl7.org/fhir/> .


[ a fhir:SubstanceDefinition;
  fhir:nodeRole fhir:treeRoot; # if this is the parser root

  # from Resource: .id, .meta, .implicitRules, and .language
  # from DomainResource: .text, .contained, .extension, and .modifierExtension
  fhir:SubstanceDefinition.identifier [ Identifier ], ... ; # 0..* Identifier by which this substance is known
  fhir:SubstanceDefinition.version [ string ]; # 0..1 A business level version identifier of the substance
  fhir:SubstanceDefinition.status [ CodeableConcept ]; # 0..1 Status of substance within the catalogue e.g. active, retired
  fhir:SubstanceDefinition.classification [ CodeableConcept ], ... ; # 0..* A categorization, high level e.g. polymer or nucleic acid, or food, chemical, biological, or lower e.g. polymer linear or branch chain, or type of impurity
  fhir:SubstanceDefinition.domain [ CodeableConcept ]; # 0..1 If the substance applies to human or veterinary use
  fhir:SubstanceDefinition.grade [ CodeableConcept ], ... ; # 0..* The quality standard, established benchmark, to which substance complies (e.g. USP/NF, BP)
  fhir:SubstanceDefinition.description [ markdown ]; # 0..1 Textual description of the substance
  fhir:SubstanceDefinition.informationSource [ Reference(Citation) ], ... ; # 0..* Supporting literature
  fhir:SubstanceDefinition.note [ Annotation ], ... ; # 0..* Textual comment about the substance's catalogue or registry record
  fhir:SubstanceDefinition.manufacturer [ Reference(Organization) ], ... ; # 0..* The entity that creates, makes, produces or fabricates the substance
  fhir:SubstanceDefinition.supplier [ Reference(Organization) ], ... ; # 0..* An entity that is the source for the substance. It may be different from the manufacturer
  fhir:SubstanceDefinition.moiety [ # 0..* Moiety, for structural modifications
    fhir:SubstanceDefinition.moiety.role [ CodeableConcept ]; # 0..1 Role that the moiety is playing
    fhir:SubstanceDefinition.moiety.identifier [ Identifier ]; # 0..1 Identifier by which this moiety substance is known
    fhir:SubstanceDefinition.moiety.name [ string ]; # 0..1 Textual name for this moiety substance
    fhir:SubstanceDefinition.moiety.stereochemistry [ CodeableConcept ]; # 0..1 Stereochemistry type
    fhir:SubstanceDefinition.moiety.opticalActivity [ CodeableConcept ]; # 0..1 Optical activity type
    fhir:SubstanceDefinition.moiety.molecularFormula [ string ]; # 0..1 Molecular formula for this moiety (e.g. with the Hill system)
    # SubstanceDefinition.moiety.amount[x] : 0..1 Quantitative value for this moiety. One of these 2
      fhir:SubstanceDefinition.moiety.amountQuantity [ Quantity ]
      fhir:SubstanceDefinition.moiety.amountString [ string ]
    fhir:SubstanceDefinition.moiety.measurementType [ CodeableConcept ]; # 0..1 The measurement type of the quantitative value
  ], ...;
  fhir:SubstanceDefinition.property [ # 0..* General specifications for this substance
    fhir:SubstanceDefinition.property.type [ CodeableConcept ]; # 1..1 A code expressing the type of property
    # SubstanceDefinition.property.value[x] : 0..1 A value for the property. One of these 5
      fhir:SubstanceDefinition.property.valueCodeableConcept [ CodeableConcept ]
      fhir:SubstanceDefinition.property.valueQuantity [ Quantity ]
      fhir:SubstanceDefinition.property.valueDate [ date ]
      fhir:SubstanceDefinition.property.valueBoolean [ boolean ]
      fhir:SubstanceDefinition.property.valueAttachment [ Attachment ]
  ], ...;
  fhir:SubstanceDefinition.molecularWeight [ # 0..* The molecular weight or weight range
    fhir:SubstanceDefinition.molecularWeight.method [ CodeableConcept ]; # 0..1 The method by which the weight was determined
    fhir:SubstanceDefinition.molecularWeight.type [ CodeableConcept ]; # 0..1 Type of molecular weight e.g. exact, average, weight average
    fhir:SubstanceDefinition.molecularWeight.amount [ Quantity ]; # 1..1 Used to capture quantitative values for a variety of elements
  ], ...;
  fhir:SubstanceDefinition.structure [ # 0..1 Structural information
    fhir:SubstanceDefinition.structure.stereochemistry [ CodeableConcept ]; # 0..1 Stereochemistry type
    fhir:SubstanceDefinition.structure.opticalActivity [ CodeableConcept ]; # 0..1 Optical activity type
    fhir:SubstanceDefinition.structure.molecularFormula [ string ]; # 0..1 Molecular formula (e.g. using the Hill system)
    fhir:SubstanceDefinition.structure.molecularFormulaByMoiety [ string ]; # 0..1 Specified per moiety according to the Hill system
    fhir:SubstanceDefinition.structure.molecularWeight [ See SubstanceDefinition.molecularWeight ]; # 0..1 The molecular weight or weight range
    fhir:SubstanceDefinition.structure.technique [ CodeableConcept ], ... ; # 0..* The method used to find the structure e.g. X-ray, NMR
    fhir:SubstanceDefinition.structure.sourceDocument [ Reference(DocumentReference) ], ... ; # 0..* Source of information for the structure
    fhir:SubstanceDefinition.structure.representation [ # 0..* A depiction of the structure or characterization of the substance
      fhir:SubstanceDefinition.structure.representation.type [ CodeableConcept ]; # 0..1 The kind of structural representation (e.g. full, partial)
      fhir:SubstanceDefinition.structure.representation.representation [ string ]; # 0..1 The structural representation or characterization as a text string in a standard format
      fhir:SubstanceDefinition.structure.representation.format [ CodeableConcept ]; # 0..1 The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format)
      fhir:SubstanceDefinition.structure.representation.document [ Reference(DocumentReference) ]; # 0..1 An attachment with the structural representation e.g. a structure graphic or AnIML file
    ], ...;
  ];
  fhir:SubstanceDefinition.code [ # 0..* Codes associated with the substance
    fhir:SubstanceDefinition.code.code [ CodeableConcept ]; # 0..1 The specific code
    fhir:SubstanceDefinition.code.status [ CodeableConcept ]; # 0..1 Status of the code assignment, for example 'provisional', 'approved'
    fhir:SubstanceDefinition.code.statusDate [ dateTime ]; # 0..1 The date at which the code status was changed
    fhir:SubstanceDefinition.code.note [ Annotation ], ... ; # 0..* Any comment can be provided in this field
    fhir:SubstanceDefinition.code.source [ Reference(DocumentReference) ], ... ; # 0..* Supporting literature
  ], ...;
  fhir:SubstanceDefinition.name [ # 0..* Names applicable to this substance
    fhir:SubstanceDefinition.name.name [ string ]; # 1..1 The actual name
    fhir:SubstanceDefinition.name.type [ CodeableConcept ]; # 0..1 Name type e.g. 'systematic',  'scientific, 'brand'
    fhir:SubstanceDefinition.name.status [ CodeableConcept ]; # 0..1 The status of the name e.g. 'current', 'proposed'
    fhir:SubstanceDefinition.name.preferred [ boolean ]; # 0..1 If this is the preferred name for this substance
    fhir:SubstanceDefinition.name.language [ CodeableConcept ], ... ; # 0..* Human language that the name is written in
    fhir:SubstanceDefinition.name.domain [ CodeableConcept ], ... ; # 0..* The use context of this name e.g. as an active ingredient or as a food colour additive
    fhir:SubstanceDefinition.name.jurisdiction [ CodeableConcept ], ... ; # 0..* The jurisdiction where this name applies
    fhir:SubstanceDefinition.name.synonym [ See SubstanceDefinition.name ], ... ; # 0..* A synonym of this particular name, by which the substance is also known
    fhir:SubstanceDefinition.name.translation [ See SubstanceDefinition.name ], ... ; # 0..* A translation for this name into another human language
    fhir:SubstanceDefinition.name.official [ # 0..* Details of the official nature of this name
      fhir:SubstanceDefinition.name.official.authority [ CodeableConcept ]; # 0..1 Which authority uses this official name
      fhir:SubstanceDefinition.name.official.status [ CodeableConcept ]; # 0..1 The status of the official name, for example 'draft', 'active'
      fhir:SubstanceDefinition.name.official.date [ dateTime ]; # 0..1 Date of official name change
    ], ...;
    fhir:SubstanceDefinition.name.source [ Reference(DocumentReference) ], ... ; # 0..* Supporting literature
  ], ...;
  fhir:SubstanceDefinition.relationship [ # 0..* A link between this substance and another
    # SubstanceDefinition.relationship.substanceDefinition[x] : 0..1 A pointer to another substance, as a resource or a representational code. One of these 2
      fhir:SubstanceDefinition.relationship.substanceDefinitionReference [ Reference(SubstanceDefinition) ]
      fhir:SubstanceDefinition.relationship.substanceDefinitionCodeableConcept [ CodeableConcept ]
    fhir:SubstanceDefinition.relationship.type [ CodeableConcept ]; # 1..1 For example "salt to parent", "active moiety"
    fhir:SubstanceDefinition.relationship.isDefining [ boolean ]; # 0..1 For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships
    # SubstanceDefinition.relationship.amount[x] : 0..1 A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other. One of these 3
      fhir:SubstanceDefinition.relationship.amountQuantity [ Quantity ]
      fhir:SubstanceDefinition.relationship.amountRatio [ Ratio ]
      fhir:SubstanceDefinition.relationship.amountString [ string ]
    fhir:SubstanceDefinition.relationship.ratioHighLimitAmount [ Ratio ]; # 0..1 For use when the numeric has an uncertain range
    fhir:SubstanceDefinition.relationship.comparator [ CodeableConcept ]; # 0..1 An operator for the amount, for example "average", "approximately", "less than"
    fhir:SubstanceDefinition.relationship.source [ Reference(DocumentReference) ], ... ; # 0..* Supporting literature
  ], ...;
  fhir:SubstanceDefinition.sourceMaterial [ # 0..1 Material or taxonomic/anatomical source
    fhir:SubstanceDefinition.sourceMaterial.type [ CodeableConcept ]; # 0..1 Classification of the origin of the raw material. e.g. cat hair is an Animal source type
    fhir:SubstanceDefinition.sourceMaterial.genus [ CodeableConcept ]; # 0..1 The genus of an organism e.g. the Latin epithet of the plant/animal scientific name
    fhir:SubstanceDefinition.sourceMaterial.species [ CodeableConcept ]; # 0..1 The species of an organism e.g. the Latin epithet of the species of the plant/animal
    fhir:SubstanceDefinition.sourceMaterial.part [ CodeableConcept ]; # 0..1 An anatomical origin of the source material within an organism
    fhir:SubstanceDefinition.sourceMaterial.countryOfOrigin [ CodeableConcept ], ... ; # 0..* The country or countries where the material is harvested
  ];
]

See the Full Difference for further information

This analysis is available as XML or JSON.

Conversions between R3 and R4

<SubstanceDefinition xmlns="http://hl7.org/fhir"> 
 <!-- from Resource: id, meta, implicitRules, and language -->
 <!-- from DomainResource: text, contained, extension, and modifierExtension -->
 <identifier><!-- 0..* Identifier Identifier by which this substance is known --></identifier>
 <version value="[string]"/><!-- 0..1 A business level version identifier of the substance -->
 <status><!-- 0..1 CodeableConcept Status of substance within the catalogue e.g. active, retired --></status>
 <classification><!-- 0..* CodeableConcept A categorization, high level e.g. polymer or nucleic acid, or food, chemical, biological, or lower e.g. polymer linear or branch chain, or type of impurity --></classification>
 <domain><!-- 0..1 CodeableConcept If the substance applies to human or veterinary use --></domain>
 <grade><!-- 0..* CodeableConcept The quality standard, established benchmark, to which substance complies (e.g. USP/NF, BP) --></grade>
 <description value="[markdown]"/><!-- 0..1 Textual description of the substance -->
 <informationSource><!-- 0..* Reference(Citation) Supporting literature --></informationSource>
 <note><!-- 0..* Annotation Textual comment about the substance's catalogue or registry record --></note>
 <manufacturer><!-- 0..* Reference(Organization) The entity that creates, makes, produces or fabricates the substance --></manufacturer>
 <supplier><!-- 0..* Reference(Organization) An entity that is the source for the substance. It may be different from the manufacturer --></supplier>
 <moiety>  <!-- 0..* Moiety, for structural modifications -->
  <role><!-- 0..1 CodeableConcept Role that the moiety is playing --></role>
  <identifier><!-- 0..1 Identifier Identifier by which this moiety substance is known --></identifier>
  <name value="[string]"/><!-- 0..1 Textual name for this moiety substance -->
  <stereochemistry><!-- 0..1 CodeableConcept Stereochemistry type --></stereochemistry>
  <opticalActivity><!-- 0..1 CodeableConcept Optical activity type --></opticalActivity>
  <molecularFormula value="[string]"/><!-- 0..1 Molecular formula for this moiety (e.g. with the Hill system) -->
  <amount[x]><!-- 0..1 Quantity|string Quantitative value for this moiety --></amount[x]>
  <measurementType><!-- 0..1 CodeableConcept The measurement type of the quantitative value --></measurementType>
 </moiety>
 <property>  <!-- 0..* General specifications for this substance -->
  <type><!-- 1..1 CodeableConcept A code expressing the type of property  --></type>
  <value[x]><!-- 0..1 CodeableConcept|Quantity|date|boolean|Attachment A value for the property --></value[x]>
 </property>
 <molecularWeight>  <!-- 0..* The molecular weight or weight range -->
  <method><!-- 0..1 CodeableConcept The method by which the weight was determined --></method>
  <type><!-- 0..1 CodeableConcept Type of molecular weight e.g. exact, average, weight average --></type>
  <amount><!-- 1..1 Quantity Used to capture quantitative values for a variety of elements --></amount>
 </molecularWeight>
 <structure>  <!-- 0..1 Structural information -->
  <stereochemistry><!-- 0..1 CodeableConcept Stereochemistry type --></stereochemistry>
  <opticalActivity><!-- 0..1 CodeableConcept Optical activity type --></opticalActivity>
  <molecularFormula value="[string]"/><!-- 0..1 Molecular formula (e.g. using the Hill system) -->
  <molecularFormulaByMoiety value="[string]"/><!-- 0..1 Specified per moiety according to the Hill system -->
  <molecularWeight><!-- 0..1 Content as for SubstanceDefinition.molecularWeight The molecular weight or weight range --></molecularWeight>
  <technique><!-- 0..* CodeableConcept The method used to find the structure e.g. X-ray, NMR --></technique>
  <sourceDocument><!-- 0..* Reference(DocumentReference) Source of information for the structure --></sourceDocument>
  <representation>  <!-- 0..* A depiction of the structure or characterization of the substance -->
   <type><!-- 0..1 CodeableConcept The kind of structural representation (e.g. full, partial) --></type>
   <representation value="[string]"/><!-- 0..1 The structural representation or characterization as a text string in a standard format -->
   <format><!-- 0..1 CodeableConcept The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format) --></format>
   <document><!-- 0..1 Reference(DocumentReference) An attachment with the structural representation e.g. a structure graphic or AnIML file --></document>
  </representation>
 </structure>
 <code>  <!-- 0..* Codes associated with the substance -->
  <code><!-- 0..1 CodeableConcept The specific code --></code>
  <status><!-- 0..1 CodeableConcept Status of the code assignment, for example 'provisional', 'approved' --></status>
  <statusDate value="[dateTime]"/><!-- 0..1 The date at which the code status was changed -->
  <note><!-- 0..* Annotation Any comment can be provided in this field --></note>
  <source><!-- 0..* Reference(DocumentReference) Supporting literature --></source>
 </code>
 <name>  <!-- 0..* Names applicable to this substance -->
  <name value="[string]"/><!-- 1..1 The actual name -->
  <type><!-- 0..1 CodeableConcept Name type e.g. 'systematic',  'scientific, 'brand' --></type>
  <status><!-- 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed' --></status>
  <preferred value="[boolean]"/><!-- 0..1 If this is the preferred name for this substance -->
  <language><!-- 0..* CodeableConcept Human language that the name is written in --></language>
  <domain><!-- 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive --></domain>
  <jurisdiction><!-- 0..* CodeableConcept The jurisdiction where this name applies --></jurisdiction>
  <synonym><!-- 0..* Content as for SubstanceDefinition.name A synonym of this particular name, by which the substance is also known --></synonym>
  <translation><!-- 0..* Content as for SubstanceDefinition.name A translation for this name into another human language --></translation>
  <official>  <!-- 0..* Details of the official nature of this name -->
   <authority><!-- 0..1 CodeableConcept Which authority uses this official name --></authority>
   <status><!-- 0..1 CodeableConcept The status of the official name, for example 'draft', 'active' --></status>
   <date value="[dateTime]"/><!-- 0..1 Date of official name change -->
  </official>
  <source><!-- 0..* Reference(DocumentReference) Supporting literature --></source>
 </name>
 <relationship>  <!-- 0..* A link between this substance and another -->
  <substanceDefinition[x]><!-- 0..1 Reference(SubstanceDefinition)|
    CodeableConcept A pointer to another substance, as a resource or a representational code --></substanceDefinition[x]>
  <type><!-- 1..1 CodeableConcept For example "salt to parent", "active moiety" --></type>
  <isDefining value="[boolean]"/><!-- 0..1 For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships -->
  <amount[x]><!-- 0..1 Quantity|Ratio|string A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other --></amount[x]>
  <ratioHighLimitAmount><!-- 0..1 Ratio For use when the numeric has an uncertain range --></ratioHighLimitAmount>
  <comparator><!-- 0..1 CodeableConcept An operator for the amount, for example "average", "approximately", "less than" --></comparator>
  <source><!-- 0..* Reference(DocumentReference) Supporting literature --></source>
 </relationship>
 <sourceMaterial>  <!-- 0..1 Material or taxonomic/anatomical source -->
  <type><!-- 0..1 CodeableConcept Classification of the origin of the raw material. e.g. cat hair is an Animal source type --></type>
  <genus><!-- 0..1 CodeableConcept The genus of an organism e.g. the Latin epithet of the plant/animal scientific name --></genus>
  <species><!-- 0..1 CodeableConcept The species of an organism e.g. the Latin epithet of the species of the plant/animal --></species>
  <part><!-- 0..1 CodeableConcept An anatomical origin of the source material within an organism --></part>
  <countryOfOrigin><!-- 0..* CodeableConcept The country or countries where the material is harvested --></countryOfOrigin>
 </sourceMaterial>
</SubstanceDefinition>

{
  "resourceType" : "SubstanceDefinition",
  // from Resource: id, meta, implicitRules, and language
  // from DomainResource: text, contained, extension, and modifierExtension
  "identifier" : [{ Identifier }], // Identifier by which this substance is known
  "version" : "<string>", // A business level version identifier of the substance
  "status" : { CodeableConcept }, // Status of substance within the catalogue e.g. active, retired
  "classification" : [{ CodeableConcept }], // A categorization, high level e.g. polymer or nucleic acid, or food, chemical, biological, or lower e.g. polymer linear or branch chain, or type of impurity
  "domain" : { CodeableConcept }, // If the substance applies to human or veterinary use
  "grade" : [{ CodeableConcept }], // The quality standard, established benchmark, to which substance complies (e.g. USP/NF, BP)
  "description" : "<markdown>", // Textual description of the substance
  "informationSource" : [{ Reference(Citation) }], // Supporting literature
  "note" : [{ Annotation }], // Textual comment about the substance's catalogue or registry record
  "manufacturer" : [{ Reference(Organization) }], // The entity that creates, makes, produces or fabricates the substance
  "supplier" : [{ Reference(Organization) }], // An entity that is the source for the substance. It may be different from the manufacturer
  "moiety" : [{ // Moiety, for structural modifications
    "role" : { CodeableConcept }, // Role that the moiety is playing
    "identifier" : { Identifier }, // Identifier by which this moiety substance is known
    "name" : "<string>", // Textual name for this moiety substance
    "stereochemistry" : { CodeableConcept }, // Stereochemistry type
    "opticalActivity" : { CodeableConcept }, // Optical activity type
    "molecularFormula" : "<string>", // Molecular formula for this moiety (e.g. with the Hill system)
    // amount[x]: Quantitative value for this moiety. One of these 2:
    "amountQuantity" : { Quantity },
    "amountString" : "<string>",
    "measurementType" : { CodeableConcept } // The measurement type of the quantitative value
  }],
  "property" : [{ // General specifications for this substance
    "type" : { CodeableConcept }, // R!  A code expressing the type of property 
    // value[x]: A value for the property. One of these 5:
    "valueCodeableConcept" : { CodeableConcept }
    "valueQuantity" : { Quantity }
    "valueDate" : "<date>"
    "valueBoolean" : <boolean>
    "valueAttachment" : { Attachment }
  }],
  "molecularWeight" : [{ // The molecular weight or weight range
    "method" : { CodeableConcept }, // The method by which the weight was determined
    "type" : { CodeableConcept }, // Type of molecular weight e.g. exact, average, weight average
    "amount" : { Quantity } // R!  Used to capture quantitative values for a variety of elements
  }],
  "structure" : { // Structural information
    "stereochemistry" : { CodeableConcept }, // Stereochemistry type
    "opticalActivity" : { CodeableConcept }, // Optical activity type
    "molecularFormula" : "<string>", // Molecular formula (e.g. using the Hill system)
    "molecularFormulaByMoiety" : "<string>", // Specified per moiety according to the Hill system
    "molecularWeight" : { Content as for SubstanceDefinition.molecularWeight }, // The molecular weight or weight range
    "technique" : [{ CodeableConcept }], // The method used to find the structure e.g. X-ray, NMR
    "sourceDocument" : [{ Reference(DocumentReference) }], // Source of information for the structure
    "representation" : [{ // A depiction of the structure or characterization of the substance
      "type" : { CodeableConcept }, // The kind of structural representation (e.g. full, partial)
      "representation" : "<string>", // The structural representation or characterization as a text string in a standard format
      "format" : { CodeableConcept }, // The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format)
      "document" : { Reference(DocumentReference) } // An attachment with the structural representation e.g. a structure graphic or AnIML file
    }]
  },
  "code" : [{ // Codes associated with the substance
    "code" : { CodeableConcept }, // The specific code
    "status" : { CodeableConcept }, // Status of the code assignment, for example 'provisional', 'approved'
    "statusDate" : "<dateTime>", // The date at which the code status was changed
    "note" : [{ Annotation }], // Any comment can be provided in this field
    "source" : [{ Reference(DocumentReference) }] // Supporting literature
  }],
  "name" : [{ // Names applicable to this substance
    "name" : "<string>", // R!  The actual name
    "type" : { CodeableConcept }, // Name type e.g. 'systematic',  'scientific, 'brand'
    "status" : { CodeableConcept }, // The status of the name e.g. 'current', 'proposed'
    "preferred" : <boolean>, // If this is the preferred name for this substance
    "language" : [{ CodeableConcept }], // Human language that the name is written in
    "domain" : [{ CodeableConcept }], // The use context of this name e.g. as an active ingredient or as a food colour additive
    "jurisdiction" : [{ CodeableConcept }], // The jurisdiction where this name applies
    "synonym" : [{ Content as for SubstanceDefinition.name }], // A synonym of this particular name, by which the substance is also known
    "translation" : [{ Content as for SubstanceDefinition.name }], // A translation for this name into another human language
    "official" : [{ // Details of the official nature of this name
      "authority" : { CodeableConcept }, // Which authority uses this official name
      "status" : { CodeableConcept }, // The status of the official name, for example 'draft', 'active'
      "date" : "<dateTime>" // Date of official name change
    }],
    "source" : [{ Reference(DocumentReference) }] // Supporting literature
  }],
  "relationship" : [{ // A link between this substance and another
    // substanceDefinition[x]: A pointer to another substance, as a resource or a representational code. One of these 2:
    "substanceDefinitionReference" : { Reference(SubstanceDefinition) },
    "substanceDefinitionCodeableConcept" : { CodeableConcept },
    "type" : { CodeableConcept }, // R!  For example "salt to parent", "active moiety"
    "isDefining" : <boolean>, // For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships
    // amount[x]: 
      A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other. One of these 3:
    "amountQuantity" : { Quantity },
    "amountRatio" : { Ratio },
    "amountString" : "<string>",
    "ratioHighLimitAmount" : { Ratio }, // For use when the numeric has an uncertain range
    "comparator" : { CodeableConcept }, // An operator for the amount, for example "average", "approximately", "less than"
    "source" : [{ Reference(DocumentReference) }] // Supporting literature
  }],
  "sourceMaterial" : { // Material or taxonomic/anatomical source
    "type" : { CodeableConcept }, // Classification of the origin of the raw material. e.g. cat hair is an Animal source type
    "genus" : { CodeableConcept }, // The genus of an organism e.g. the Latin epithet of the plant/animal scientific name
    "species" : { CodeableConcept }, // The species of an organism e.g. the Latin epithet of the species of the plant/animal
    "part" : { CodeableConcept }, // An anatomical origin of the source material within an organism
    "countryOfOrigin" : [{ CodeableConcept }] // The country or countries where the material is harvested
  }
}

@prefix fhir: <http://hl7.org/fhir/> .


[ a fhir:SubstanceDefinition;
  fhir:nodeRole fhir:treeRoot; # if this is the parser root

  # from Resource: .id, .meta, .implicitRules, and .language
  # from DomainResource: .text, .contained, .extension, and .modifierExtension
  fhir:SubstanceDefinition.identifier [ Identifier ], ... ; # 0..* Identifier by which this substance is known
  fhir:SubstanceDefinition.version [ string ]; # 0..1 A business level version identifier of the substance
  fhir:SubstanceDefinition.status [ CodeableConcept ]; # 0..1 Status of substance within the catalogue e.g. active, retired
  fhir:SubstanceDefinition.classification [ CodeableConcept ], ... ; # 0..* A categorization, high level e.g. polymer or nucleic acid, or food, chemical, biological, or lower e.g. polymer linear or branch chain, or type of impurity
  fhir:SubstanceDefinition.domain [ CodeableConcept ]; # 0..1 If the substance applies to human or veterinary use
  fhir:SubstanceDefinition.grade [ CodeableConcept ], ... ; # 0..* The quality standard, established benchmark, to which substance complies (e.g. USP/NF, BP)
  fhir:SubstanceDefinition.description [ markdown ]; # 0..1 Textual description of the substance
  fhir:SubstanceDefinition.informationSource [ Reference(Citation) ], ... ; # 0..* Supporting literature
  fhir:SubstanceDefinition.note [ Annotation ], ... ; # 0..* Textual comment about the substance's catalogue or registry record
  fhir:SubstanceDefinition.manufacturer [ Reference(Organization) ], ... ; # 0..* The entity that creates, makes, produces or fabricates the substance
  fhir:SubstanceDefinition.supplier [ Reference(Organization) ], ... ; # 0..* An entity that is the source for the substance. It may be different from the manufacturer
  fhir:SubstanceDefinition.moiety [ # 0..* Moiety, for structural modifications
    fhir:SubstanceDefinition.moiety.role [ CodeableConcept ]; # 0..1 Role that the moiety is playing
    fhir:SubstanceDefinition.moiety.identifier [ Identifier ]; # 0..1 Identifier by which this moiety substance is known
    fhir:SubstanceDefinition.moiety.name [ string ]; # 0..1 Textual name for this moiety substance
    fhir:SubstanceDefinition.moiety.stereochemistry [ CodeableConcept ]; # 0..1 Stereochemistry type
    fhir:SubstanceDefinition.moiety.opticalActivity [ CodeableConcept ]; # 0..1 Optical activity type
    fhir:SubstanceDefinition.moiety.molecularFormula [ string ]; # 0..1 Molecular formula for this moiety (e.g. with the Hill system)
    # SubstanceDefinition.moiety.amount[x] : 0..1 Quantitative value for this moiety. One of these 2
      fhir:SubstanceDefinition.moiety.amountQuantity [ Quantity ]
      fhir:SubstanceDefinition.moiety.amountString [ string ]
    fhir:SubstanceDefinition.moiety.measurementType [ CodeableConcept ]; # 0..1 The measurement type of the quantitative value
  ], ...;
  fhir:SubstanceDefinition.property [ # 0..* General specifications for this substance
    fhir:SubstanceDefinition.property.type [ CodeableConcept ]; # 1..1 A code expressing the type of property
    # SubstanceDefinition.property.value[x] : 0..1 A value for the property. One of these 5
      fhir:SubstanceDefinition.property.valueCodeableConcept [ CodeableConcept ]
      fhir:SubstanceDefinition.property.valueQuantity [ Quantity ]
      fhir:SubstanceDefinition.property.valueDate [ date ]
      fhir:SubstanceDefinition.property.valueBoolean [ boolean ]
      fhir:SubstanceDefinition.property.valueAttachment [ Attachment ]
  ], ...;
  fhir:SubstanceDefinition.molecularWeight [ # 0..* The molecular weight or weight range
    fhir:SubstanceDefinition.molecularWeight.method [ CodeableConcept ]; # 0..1 The method by which the weight was determined
    fhir:SubstanceDefinition.molecularWeight.type [ CodeableConcept ]; # 0..1 Type of molecular weight e.g. exact, average, weight average
    fhir:SubstanceDefinition.molecularWeight.amount [ Quantity ]; # 1..1 Used to capture quantitative values for a variety of elements
  ], ...;
  fhir:SubstanceDefinition.structure [ # 0..1 Structural information
    fhir:SubstanceDefinition.structure.stereochemistry [ CodeableConcept ]; # 0..1 Stereochemistry type
    fhir:SubstanceDefinition.structure.opticalActivity [ CodeableConcept ]; # 0..1 Optical activity type
    fhir:SubstanceDefinition.structure.molecularFormula [ string ]; # 0..1 Molecular formula (e.g. using the Hill system)
    fhir:SubstanceDefinition.structure.molecularFormulaByMoiety [ string ]; # 0..1 Specified per moiety according to the Hill system
    fhir:SubstanceDefinition.structure.molecularWeight [ See SubstanceDefinition.molecularWeight ]; # 0..1 The molecular weight or weight range
    fhir:SubstanceDefinition.structure.technique [ CodeableConcept ], ... ; # 0..* The method used to find the structure e.g. X-ray, NMR
    fhir:SubstanceDefinition.structure.sourceDocument [ Reference(DocumentReference) ], ... ; # 0..* Source of information for the structure
    fhir:SubstanceDefinition.structure.representation [ # 0..* A depiction of the structure or characterization of the substance
      fhir:SubstanceDefinition.structure.representation.type [ CodeableConcept ]; # 0..1 The kind of structural representation (e.g. full, partial)
      fhir:SubstanceDefinition.structure.representation.representation [ string ]; # 0..1 The structural representation or characterization as a text string in a standard format
      fhir:SubstanceDefinition.structure.representation.format [ CodeableConcept ]; # 0..1 The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format)
      fhir:SubstanceDefinition.structure.representation.document [ Reference(DocumentReference) ]; # 0..1 An attachment with the structural representation e.g. a structure graphic or AnIML file
    ], ...;
  ];
  fhir:SubstanceDefinition.code [ # 0..* Codes associated with the substance
    fhir:SubstanceDefinition.code.code [ CodeableConcept ]; # 0..1 The specific code
    fhir:SubstanceDefinition.code.status [ CodeableConcept ]; # 0..1 Status of the code assignment, for example 'provisional', 'approved'
    fhir:SubstanceDefinition.code.statusDate [ dateTime ]; # 0..1 The date at which the code status was changed
    fhir:SubstanceDefinition.code.note [ Annotation ], ... ; # 0..* Any comment can be provided in this field
    fhir:SubstanceDefinition.code.source [ Reference(DocumentReference) ], ... ; # 0..* Supporting literature
  ], ...;
  fhir:SubstanceDefinition.name [ # 0..* Names applicable to this substance
    fhir:SubstanceDefinition.name.name [ string ]; # 1..1 The actual name
    fhir:SubstanceDefinition.name.type [ CodeableConcept ]; # 0..1 Name type e.g. 'systematic',  'scientific, 'brand'
    fhir:SubstanceDefinition.name.status [ CodeableConcept ]; # 0..1 The status of the name e.g. 'current', 'proposed'
    fhir:SubstanceDefinition.name.preferred [ boolean ]; # 0..1 If this is the preferred name for this substance
    fhir:SubstanceDefinition.name.language [ CodeableConcept ], ... ; # 0..* Human language that the name is written in
    fhir:SubstanceDefinition.name.domain [ CodeableConcept ], ... ; # 0..* The use context of this name e.g. as an active ingredient or as a food colour additive
    fhir:SubstanceDefinition.name.jurisdiction [ CodeableConcept ], ... ; # 0..* The jurisdiction where this name applies
    fhir:SubstanceDefinition.name.synonym [ See SubstanceDefinition.name ], ... ; # 0..* A synonym of this particular name, by which the substance is also known
    fhir:SubstanceDefinition.name.translation [ See SubstanceDefinition.name ], ... ; # 0..* A translation for this name into another human language
    fhir:SubstanceDefinition.name.official [ # 0..* Details of the official nature of this name
      fhir:SubstanceDefinition.name.official.authority [ CodeableConcept ]; # 0..1 Which authority uses this official name
      fhir:SubstanceDefinition.name.official.status [ CodeableConcept ]; # 0..1 The status of the official name, for example 'draft', 'active'
      fhir:SubstanceDefinition.name.official.date [ dateTime ]; # 0..1 Date of official name change
    ], ...;
    fhir:SubstanceDefinition.name.source [ Reference(DocumentReference) ], ... ; # 0..* Supporting literature
  ], ...;
  fhir:SubstanceDefinition.relationship [ # 0..* A link between this substance and another
    # SubstanceDefinition.relationship.substanceDefinition[x] : 0..1 A pointer to another substance, as a resource or a representational code. One of these 2
      fhir:SubstanceDefinition.relationship.substanceDefinitionReference [ Reference(SubstanceDefinition) ]
      fhir:SubstanceDefinition.relationship.substanceDefinitionCodeableConcept [ CodeableConcept ]
    fhir:SubstanceDefinition.relationship.type [ CodeableConcept ]; # 1..1 For example "salt to parent", "active moiety"
    fhir:SubstanceDefinition.relationship.isDefining [ boolean ]; # 0..1 For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships
    # SubstanceDefinition.relationship.amount[x] : 0..1 A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other. One of these 3
      fhir:SubstanceDefinition.relationship.amountQuantity [ Quantity ]
      fhir:SubstanceDefinition.relationship.amountRatio [ Ratio ]
      fhir:SubstanceDefinition.relationship.amountString [ string ]
    fhir:SubstanceDefinition.relationship.ratioHighLimitAmount [ Ratio ]; # 0..1 For use when the numeric has an uncertain range
    fhir:SubstanceDefinition.relationship.comparator [ CodeableConcept ]; # 0..1 An operator for the amount, for example "average", "approximately", "less than"
    fhir:SubstanceDefinition.relationship.source [ Reference(DocumentReference) ], ... ; # 0..* Supporting literature
  ], ...;
  fhir:SubstanceDefinition.sourceMaterial [ # 0..1 Material or taxonomic/anatomical source
    fhir:SubstanceDefinition.sourceMaterial.type [ CodeableConcept ]; # 0..1 Classification of the origin of the raw material. e.g. cat hair is an Animal source type
    fhir:SubstanceDefinition.sourceMaterial.genus [ CodeableConcept ]; # 0..1 The genus of an organism e.g. the Latin epithet of the plant/animal scientific name
    fhir:SubstanceDefinition.sourceMaterial.species [ CodeableConcept ]; # 0..1 The species of an organism e.g. the Latin epithet of the species of the plant/animal
    fhir:SubstanceDefinition.sourceMaterial.part [ CodeableConcept ]; # 0..1 An anatomical origin of the source material within an organism
    fhir:SubstanceDefinition.sourceMaterial.countryOfOrigin [ CodeableConcept ], ... ; # 0..* The country or countries where the material is harvested
  ];
]

See the Full Difference for further information

This analysis is available as XML or JSON.

Conversions between R3 and R4