11.19 Resource SubstanceDefinition - Content

<SubstanceDefinition xmlns="http://hl7.org/fhir"> 
 <!-- from Resource: id, meta, implicitRules, and language -->
 <!-- from DomainResource: text, contained, extension, and modifierExtension -->
 <identifier><!-- 0..1 Identifier Identifier by which this substance is known --></identifier>
 <version value="[string]"/><!-- 0..1 A business level identifier of the substance -->
 <status><!-- 0..1 CodeableConcept Status of substance within the catalogue e.g. approved --></status>
 <category><!-- 0..1 CodeableConcept High level categorization, e.g. polymer or nucleic acid, or food, chemical, biological --></category>
 <domain><!-- 0..1 CodeableConcept If the substance applies to only human or veterinary use --></domain>
 <description value="[markdown]"/><!-- 0..1 Textual description of the substance -->
 <source><!-- 0..* Reference(DocumentReference) Supporting literature --></source>
 <note><!-- 0..* Annotation Textual comment about this record of a substance --></note>
 <manufacturer><!-- 0..* Reference(Organization) A company that makes this substance --></manufacturer>
 <supplier><!-- 0..* Reference(Organization) A company that supplies this substance --></supplier>
 <moiety>  <!-- 0..* Moiety, for structural modifications -->
  <role><!-- 0..1 CodeableConcept Role that the moiety is playing --></role>
  <identifier><!-- 0..1 Identifier Identifier by which this moiety substance is known --></identifier>
  <name value="[string]"/><!-- 0..1 Textual name for this moiety substance -->
  <stereochemistry><!-- 0..1 CodeableConcept Stereochemistry type --></stereochemistry>
  <opticalActivity><!-- 0..1 CodeableConcept Optical activity type --></opticalActivity>
  <molecularFormula value="[string]"/><!-- 0..1 Molecular formula for this moiety of this substance, typically using the Hill system -->
  <amount[x]><!-- 0..1 Quantity|string Quantitative value for this moiety --></amount[x]>
  <amountType><!-- 0..1 CodeableConcept The measurement type of the quantitative value --></amountType>
 </moiety>
 <property>  <!-- 0..* General specifications for this substance, including how it is related to other substances -->
  <category><!-- 0..1 CodeableConcept A category for this property, e.g. Physical, Chemical, Enzymatic --></category>
  <code><!-- 0..1 CodeableConcept Property type e.g. viscosity, pH, isoelectric point --></code>
  <parameters value="[string]"/><!-- 0..1 Parameters that were used in the measurement of a property (e.g. for viscosity: measured at 20C with a pH of 7.1) -->
  <definingSubstance[x]><!-- 0..1 Reference(Substance|SubstanceDefinition)|
    CodeableConcept A substance upon which a defining property depends (e.g. for solubility: in water, in alcohol) --></definingSubstance[x]>
  <amount[x]><!-- 0..1 Quantity|string Quantitative value for this property --></amount[x]>
  <referenceRange><!-- 0..1 Range Range of typical values --></referenceRange>
  <source><!-- 0..* Reference(DocumentReference) Supporting literature --></source>
 </property>
 <referenceInformation><!-- 0..1 Reference(SubstanceReferenceInformation) General information detailing this substance --></referenceInformation>
 <structure>  <!-- 0..1 Structural information -->
  <stereochemistry><!-- 0..1 CodeableConcept Stereochemistry type --></stereochemistry>
  <opticalActivity><!-- 0..1 CodeableConcept Optical activity type --></opticalActivity>
  <molecularFormula value="[string]"/><!-- 0..1 Molecular formula of this substance, typically using the Hill system -->
  <molecularFormulaByMoiety value="[string]"/><!-- 0..1 Specified per moiety according to the Hill system, i.e. first C, then H, then alphabetical, each moiety separated by a dot -->
  <isotope>  <!-- 0..* Applicable for single substances that contain a radionuclide or a non-natural isotopic ratio -->
   <identifier><!-- 0..1 Identifier Substance identifier for each non-natural or radioisotope --></identifier>
   <name><!-- 0..1 CodeableConcept Substance name for each non-natural or radioisotope --></name>
   <substitution><!-- 0..1 CodeableConcept The type of isotopic substitution present in a single substance --></substitution>
   <halfLife><!-- 0..1 Quantity Half life - for a non-natural nuclide --></halfLife>
   <molecularWeight>  <!-- 0..1 The molecular weight or weight range (for proteins, polymers or nucleic acids) -->
    <method><!-- 0..1 CodeableConcept The method by which the molecular weight was determined --></method>
    <type><!-- 0..1 CodeableConcept Type of molecular weight such as exact, average (also known as. number average), weight average --></type>
    <amount><!-- 0..1 Quantity Used to capture quantitative values for a variety of elements. If only limits are given, the arithmetic mean would be the average. If only a single definite value for a given element is given, it would be captured in this field --></amount>
   </molecularWeight>
  </isotope>
  <molecularWeight><!-- 0..1 Content as for SubstanceDefinition.structure.isotope.molecularWeight The molecular weight or weight range (for proteins, polymers or nucleic acids) --></molecularWeight>
  <sourceCoding><!-- 0..* Coding Describes the source of information --></sourceCoding>
  <sourceDocument><!-- 0..* Reference(DocumentReference) Supporting literature about the source of information --></sourceDocument>
  <representation>  <!-- 0..* Molecular structural representation -->
   <type><!-- 0..1 CodeableConcept The type of structure (e.g. Full, Partial, Representative) --></type>
   <representation value="[string]"/><!-- 0..1 The structural representation as text string in a format e.g. InChI, SMILES, MOLFILE, CDX -->
   <attachment><!-- 0..1 Attachment An attached file with the structural representation --></attachment>
  </representation>
 </structure>
 <code>  <!-- 0..* Codes associated with the substance -->
  <code><!-- 0..1 CodeableConcept The specific code --></code>
  <status><!-- 0..1 CodeableConcept Status of the code assignment, for example 'provisional', 'approved' --></status>
  <statusDate value="[dateTime]"/><!-- 0..1 The date at which the code status is changed as part of the terminology maintenance -->
  <note><!-- 0..* Annotation Any comment can be provided in this field, if necessary --></note>
  <source><!-- 0..* Reference(DocumentReference) Supporting literature --></source>
 </code>
 <name>  <!-- 0..* Names applicable to this substance -->
  <name value="[string]"/><!-- 1..1 The actual name -->
  <type><!-- 0..1 CodeableConcept Name type, for example 'systematic',  'scientific, 'brand' --></type>
  <status><!-- 0..1 CodeableConcept The status of the name, for example 'current', 'proposed' --></status>
  <preferred value="[boolean]"/><!-- 0..1 If this is the preferred name for this substance -->
  <language><!-- 0..* CodeableConcept Human language that the name is written in --></language>
  <domain><!-- 0..* CodeableConcept The use context of this name for example if there is a different name a drug active ingredient as opposed to a food colour additive --></domain>
  <jurisdiction><!-- 0..* CodeableConcept The jurisdiction where this name applies --></jurisdiction>
  <synonym><!-- 0..* Content as for SubstanceDefinition.name A synonym of this particular name, by which the substance is also known --></synonym>
  <translation><!-- 0..* Content as for SubstanceDefinition.name A translation for this name into another human language --></translation>
  <official>  <!-- 0..* Details of the official nature of this name -->
   <authority><!-- 0..1 CodeableConcept Which authority uses this official name --></authority>
   <status><!-- 0..1 CodeableConcept The status of the official name, for example 'provisional', 'approved' --></status>
   <date value="[dateTime]"/><!-- 0..1 Date of official name change -->
  </official>
  <source><!-- 0..* Reference(DocumentReference) Supporting literature --></source>
 </name>
 <molecularWeight><!-- 0..* Content as for SubstanceDefinition.structure.isotope.molecularWeight The molecular weight or weight range (for proteins, polymers or nucleic acids) --></molecularWeight>
 <relationship>  <!-- 0..* A link between this substance and another, with details of the relationship -->
  <substanceDefinition[x]><!-- 0..1 Reference(SubstanceDefinition)|
    CodeableConcept A pointer to another substance, as a resource or just a representational code --></substanceDefinition[x]>
  <type><!-- 0..1 CodeableConcept For example "salt to parent", "active moiety", "starting material", "polymorph" --></type>
  <isDefining value="[boolean]"/><!-- 0..1 For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible substance relationships -->
  <amount[x]><!-- 0..1 Quantity|Range|Ratio|string A numeric factor for the relationship, for instance to express that the salt of a substance has some percentage of the active substance in relation to some other --></amount[x]>
  <amountRatioHighLimit><!-- 0..1 Ratio For use when the numeric has an uncertain range --></amountRatioHighLimit>
  <amountType><!-- 0..1 CodeableConcept An operator for the amount, for example "average", "approximately", "less than" --></amountType>
  <source><!-- 0..* Reference(DocumentReference) Supporting literature --></source>
 </relationship>
 <nucleicAcid><!-- 0..1 Reference(SubstanceNucleicAcid) Data items specific to nucleic acids --></nucleicAcid>
 <polymer><!-- 0..1 Reference(SubstancePolymer) Data items specific to polymers --></polymer>
 <protein><!-- 0..1 Reference(SubstanceProtein) Data items specific to proteins --></protein>
 <sourceMaterial><!-- 0..1 Reference(SubstanceSourceMaterial) Material or taxonomic/anatomical source for the substance --></sourceMaterial>
</SubstanceDefinition>

{
  "resourceType" : "SubstanceDefinition",
  // from Resource: id, meta, implicitRules, and language
  // from DomainResource: text, contained, extension, and modifierExtension
  "identifier" : { Identifier }, // Identifier by which this substance is known
  "version" : "<string>", // A business level identifier of the substance
  "status" : { CodeableConcept }, // Status of substance within the catalogue e.g. approved
  "category" : { CodeableConcept }, // High level categorization, e.g. polymer or nucleic acid, or food, chemical, biological
  "domain" : { CodeableConcept }, // If the substance applies to only human or veterinary use
  "description" : "<markdown>", // Textual description of the substance
  "source" : [{ Reference(DocumentReference) }], // Supporting literature
  "note" : [{ Annotation }], // Textual comment about this record of a substance
  "manufacturer" : [{ Reference(Organization) }], // A company that makes this substance
  "supplier" : [{ Reference(Organization) }], // A company that supplies this substance
  "moiety" : [{ // Moiety, for structural modifications
    "role" : { CodeableConcept }, // Role that the moiety is playing
    "identifier" : { Identifier }, // Identifier by which this moiety substance is known
    "name" : "<string>", // Textual name for this moiety substance
    "stereochemistry" : { CodeableConcept }, // Stereochemistry type
    "opticalActivity" : { CodeableConcept }, // Optical activity type
    "molecularFormula" : "<string>", // Molecular formula for this moiety of this substance, typically using the Hill system
    // amount[x]: Quantitative value for this moiety. One of these 2:
    "amountQuantity" : { Quantity },
    "amountString" : "<string>",
    "amountType" : { CodeableConcept } // The measurement type of the quantitative value
  }],
  "property" : [{ // General specifications for this substance, including how it is related to other substances
    "category" : { CodeableConcept }, // A category for this property, e.g. Physical, Chemical, Enzymatic
    "code" : { CodeableConcept }, // Property type e.g. viscosity, pH, isoelectric point
    "parameters" : "<string>", // Parameters that were used in the measurement of a property (e.g. for viscosity: measured at 20C with a pH of 7.1)
    // definingSubstance[x]: 
      A substance upon which a defining property depends (e.g. for solubility: in water, in alcohol). One of these 2:
    "definingSubstanceReference" : { Reference(Substance|SubstanceDefinition) },
    "definingSubstanceCodeableConcept" : { CodeableConcept },
    // amount[x]: Quantitative value for this property. One of these 2:
    "amountQuantity" : { Quantity },
    "amountString" : "<string>",
    "referenceRange" : { Range }, // Range of typical values
    "source" : [{ Reference(DocumentReference) }] // Supporting literature
  }],
  "referenceInformation" : { Reference(SubstanceReferenceInformation) }, // General information detailing this substance
  "structure" : { // Structural information
    "stereochemistry" : { CodeableConcept }, // Stereochemistry type
    "opticalActivity" : { CodeableConcept }, // Optical activity type
    "molecularFormula" : "<string>", // Molecular formula of this substance, typically using the Hill system
    "molecularFormulaByMoiety" : "<string>", // Specified per moiety according to the Hill system, i.e. first C, then H, then alphabetical, each moiety separated by a dot
    "isotope" : [{ // Applicable for single substances that contain a radionuclide or a non-natural isotopic ratio
      "identifier" : { Identifier }, // Substance identifier for each non-natural or radioisotope
      "name" : { CodeableConcept }, // Substance name for each non-natural or radioisotope
      "substitution" : { CodeableConcept }, // The type of isotopic substitution present in a single substance
      "halfLife" : { Quantity }, // Half life - for a non-natural nuclide
      "molecularWeight" : { // The molecular weight or weight range (for proteins, polymers or nucleic acids)
        "method" : { CodeableConcept }, // The method by which the molecular weight was determined
        "type" : { CodeableConcept }, // Type of molecular weight such as exact, average (also known as. number average), weight average
        "amount" : { Quantity } // Used to capture quantitative values for a variety of elements. If only limits are given, the arithmetic mean would be the average. If only a single definite value for a given element is given, it would be captured in this field
      }
    }],
    "molecularWeight" : { Content as for SubstanceDefinition.structure.isotope.molecularWeight }, // The molecular weight or weight range (for proteins, polymers or nucleic acids)
    "sourceCoding" : [{ Coding }], // Describes the source of information
    "sourceDocument" : [{ Reference(DocumentReference) }], // Supporting literature about the source of information
    "representation" : [{ // Molecular structural representation
      "type" : { CodeableConcept }, // The type of structure (e.g. Full, Partial, Representative)
      "representation" : "<string>", // The structural representation as text string in a format e.g. InChI, SMILES, MOLFILE, CDX
      "attachment" : { Attachment } // An attached file with the structural representation
    }]
  },
  "code" : [{ // Codes associated with the substance
    "code" : { CodeableConcept }, // The specific code
    "status" : { CodeableConcept }, // Status of the code assignment, for example 'provisional', 'approved'
    "statusDate" : "<dateTime>", // The date at which the code status is changed as part of the terminology maintenance
    "note" : [{ Annotation }], // Any comment can be provided in this field, if necessary
    "source" : [{ Reference(DocumentReference) }] // Supporting literature
  }],
  "name" : [{ // Names applicable to this substance
    "name" : "<string>", // R!  The actual name
    "type" : { CodeableConcept }, // Name type, for example 'systematic',  'scientific, 'brand'
    "status" : { CodeableConcept }, // The status of the name, for example 'current', 'proposed'
    "preferred" : <boolean>, // If this is the preferred name for this substance
    "language" : [{ CodeableConcept }], // Human language that the name is written in
    "domain" : [{ CodeableConcept }], // The use context of this name for example if there is a different name a drug active ingredient as opposed to a food colour additive
    "jurisdiction" : [{ CodeableConcept }], // The jurisdiction where this name applies
    "synonym" : [{ Content as for SubstanceDefinition.name }], // A synonym of this particular name, by which the substance is also known
    "translation" : [{ Content as for SubstanceDefinition.name }], // A translation for this name into another human language
    "official" : [{ // Details of the official nature of this name
      "authority" : { CodeableConcept }, // Which authority uses this official name
      "status" : { CodeableConcept }, // The status of the official name, for example 'provisional', 'approved'
      "date" : "<dateTime>" // Date of official name change
    }],
    "source" : [{ Reference(DocumentReference) }] // Supporting literature
  }],
  "molecularWeight" : [{ Content as for SubstanceDefinition.structure.isotope.molecularWeight }], // The molecular weight or weight range (for proteins, polymers or nucleic acids)
  "relationship" : [{ // A link between this substance and another, with details of the relationship
    // substanceDefinition[x]: 
      A pointer to another substance, as a resource or just a representational code. One of these 2:
    "substanceDefinitionReference" : { Reference(SubstanceDefinition) },
    "substanceDefinitionCodeableConcept" : { CodeableConcept },
    "type" : { CodeableConcept }, // For example "salt to parent", "active moiety", "starting material", "polymorph"
    "isDefining" : <boolean>, // For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible substance relationships
    // amount[x]: 
      A numeric factor for the relationship, for instance to express that the salt of a substance has some percentage of the active substance in relation to some other. One of these 4:
    "amountQuantity" : { Quantity },
    "amountRange" : { Range },
    "amountRatio" : { Ratio },
    "amountString" : "<string>",
    "amountRatioHighLimit" : { Ratio }, // For use when the numeric has an uncertain range
    "amountType" : { CodeableConcept }, // An operator for the amount, for example "average", "approximately", "less than"
    "source" : [{ Reference(DocumentReference) }] // Supporting literature
  }],
  "nucleicAcid" : { Reference(SubstanceNucleicAcid) }, // Data items specific to nucleic acids
  "polymer" : { Reference(SubstancePolymer) }, // Data items specific to polymers
  "protein" : { Reference(SubstanceProtein) }, // Data items specific to proteins
  "sourceMaterial" : { Reference(SubstanceSourceMaterial) } // Material or taxonomic/anatomical source for the substance
}

@prefix fhir: <http://hl7.org/fhir/> .


[ a fhir:SubstanceDefinition;
  fhir:nodeRole fhir:treeRoot; # if this is the parser root

  # from Resource: .id, .meta, .implicitRules, and .language
  # from DomainResource: .text, .contained, .extension, and .modifierExtension
  fhir:SubstanceDefinition.identifier [ Identifier ]; # 0..1 Identifier by which this substance is known
  fhir:SubstanceDefinition.version [ string ]; # 0..1 A business level identifier of the substance
  fhir:SubstanceDefinition.status [ CodeableConcept ]; # 0..1 Status of substance within the catalogue e.g. approved
  fhir:SubstanceDefinition.category [ CodeableConcept ]; # 0..1 High level categorization, e.g. polymer or nucleic acid, or food, chemical, biological
  fhir:SubstanceDefinition.domain [ CodeableConcept ]; # 0..1 If the substance applies to only human or veterinary use
  fhir:SubstanceDefinition.description [ markdown ]; # 0..1 Textual description of the substance
  fhir:SubstanceDefinition.source [ Reference(DocumentReference) ], ... ; # 0..* Supporting literature
  fhir:SubstanceDefinition.note [ Annotation ], ... ; # 0..* Textual comment about this record of a substance
  fhir:SubstanceDefinition.manufacturer [ Reference(Organization) ], ... ; # 0..* A company that makes this substance
  fhir:SubstanceDefinition.supplier [ Reference(Organization) ], ... ; # 0..* A company that supplies this substance
  fhir:SubstanceDefinition.moiety [ # 0..* Moiety, for structural modifications
    fhir:SubstanceDefinition.moiety.role [ CodeableConcept ]; # 0..1 Role that the moiety is playing
    fhir:SubstanceDefinition.moiety.identifier [ Identifier ]; # 0..1 Identifier by which this moiety substance is known
    fhir:SubstanceDefinition.moiety.name [ string ]; # 0..1 Textual name for this moiety substance
    fhir:SubstanceDefinition.moiety.stereochemistry [ CodeableConcept ]; # 0..1 Stereochemistry type
    fhir:SubstanceDefinition.moiety.opticalActivity [ CodeableConcept ]; # 0..1 Optical activity type
    fhir:SubstanceDefinition.moiety.molecularFormula [ string ]; # 0..1 Molecular formula for this moiety of this substance, typically using the Hill system
    # SubstanceDefinition.moiety.amount[x] : 0..1 Quantitative value for this moiety. One of these 2
      fhir:SubstanceDefinition.moiety.amountQuantity [ Quantity ]
      fhir:SubstanceDefinition.moiety.amountString [ string ]
    fhir:SubstanceDefinition.moiety.amountType [ CodeableConcept ]; # 0..1 The measurement type of the quantitative value
  ], ...;
  fhir:SubstanceDefinition.property [ # 0..* General specifications for this substance, including how it is related to other substances
    fhir:SubstanceDefinition.property.category [ CodeableConcept ]; # 0..1 A category for this property, e.g. Physical, Chemical, Enzymatic
    fhir:SubstanceDefinition.property.code [ CodeableConcept ]; # 0..1 Property type e.g. viscosity, pH, isoelectric point
    fhir:SubstanceDefinition.property.parameters [ string ]; # 0..1 Parameters that were used in the measurement of a property (e.g. for viscosity: measured at 20C with a pH of 7.1)
    # SubstanceDefinition.property.definingSubstance[x] : 0..1 A substance upon which a defining property depends (e.g. for solubility: in water, in alcohol). One of these 2
      fhir:SubstanceDefinition.property.definingSubstanceReference [ Reference(Substance|SubstanceDefinition) ]
      fhir:SubstanceDefinition.property.definingSubstanceCodeableConcept [ CodeableConcept ]
    # SubstanceDefinition.property.amount[x] : 0..1 Quantitative value for this property. One of these 2
      fhir:SubstanceDefinition.property.amountQuantity [ Quantity ]
      fhir:SubstanceDefinition.property.amountString [ string ]
    fhir:SubstanceDefinition.property.referenceRange [ Range ]; # 0..1 Range of typical values
    fhir:SubstanceDefinition.property.source [ Reference(DocumentReference) ], ... ; # 0..* Supporting literature
  ], ...;
  fhir:SubstanceDefinition.referenceInformation [ Reference(SubstanceReferenceInformation) ]; # 0..1 General information detailing this substance
  fhir:SubstanceDefinition.structure [ # 0..1 Structural information
    fhir:SubstanceDefinition.structure.stereochemistry [ CodeableConcept ]; # 0..1 Stereochemistry type
    fhir:SubstanceDefinition.structure.opticalActivity [ CodeableConcept ]; # 0..1 Optical activity type
    fhir:SubstanceDefinition.structure.molecularFormula [ string ]; # 0..1 Molecular formula of this substance, typically using the Hill system
    fhir:SubstanceDefinition.structure.molecularFormulaByMoiety [ string ]; # 0..1 Specified per moiety according to the Hill system, i.e. first C, then H, then alphabetical, each moiety separated by a dot
    fhir:SubstanceDefinition.structure.isotope [ # 0..* Applicable for single substances that contain a radionuclide or a non-natural isotopic ratio
      fhir:SubstanceDefinition.structure.isotope.identifier [ Identifier ]; # 0..1 Substance identifier for each non-natural or radioisotope
      fhir:SubstanceDefinition.structure.isotope.name [ CodeableConcept ]; # 0..1 Substance name for each non-natural or radioisotope
      fhir:SubstanceDefinition.structure.isotope.substitution [ CodeableConcept ]; # 0..1 The type of isotopic substitution present in a single substance
      fhir:SubstanceDefinition.structure.isotope.halfLife [ Quantity ]; # 0..1 Half life - for a non-natural nuclide
      fhir:SubstanceDefinition.structure.isotope.molecularWeight [ # 0..1 The molecular weight or weight range (for proteins, polymers or nucleic acids)
        fhir:SubstanceDefinition.structure.isotope.molecularWeight.method [ CodeableConcept ]; # 0..1 The method by which the molecular weight was determined
        fhir:SubstanceDefinition.structure.isotope.molecularWeight.type [ CodeableConcept ]; # 0..1 Type of molecular weight such as exact, average (also known as. number average), weight average
        fhir:SubstanceDefinition.structure.isotope.molecularWeight.amount [ Quantity ]; # 0..1 Used to capture quantitative values for a variety of elements. If only limits are given, the arithmetic mean would be the average. If only a single definite value for a given element is given, it would be captured in this field
      ];
    ], ...;
    fhir:SubstanceDefinition.structure.molecularWeight [ See SubstanceDefinition.structure.isotope.molecularWeight ]; # 0..1 The molecular weight or weight range (for proteins, polymers or nucleic acids)
    fhir:SubstanceDefinition.structure.sourceCoding [ Coding ], ... ; # 0..* Describes the source of information
    fhir:SubstanceDefinition.structure.sourceDocument [ Reference(DocumentReference) ], ... ; # 0..* Supporting literature about the source of information
    fhir:SubstanceDefinition.structure.representation [ # 0..* Molecular structural representation
      fhir:SubstanceDefinition.structure.representation.type [ CodeableConcept ]; # 0..1 The type of structure (e.g. Full, Partial, Representative)
      fhir:SubstanceDefinition.structure.representation.representation [ string ]; # 0..1 The structural representation as text string in a format e.g. InChI, SMILES, MOLFILE, CDX
      fhir:SubstanceDefinition.structure.representation.attachment [ Attachment ]; # 0..1 An attached file with the structural representation
    ], ...;
  ];
  fhir:SubstanceDefinition.code [ # 0..* Codes associated with the substance
    fhir:SubstanceDefinition.code.code [ CodeableConcept ]; # 0..1 The specific code
    fhir:SubstanceDefinition.code.status [ CodeableConcept ]; # 0..1 Status of the code assignment, for example 'provisional', 'approved'
    fhir:SubstanceDefinition.code.statusDate [ dateTime ]; # 0..1 The date at which the code status is changed as part of the terminology maintenance
    fhir:SubstanceDefinition.code.note [ Annotation ], ... ; # 0..* Any comment can be provided in this field, if necessary
    fhir:SubstanceDefinition.code.source [ Reference(DocumentReference) ], ... ; # 0..* Supporting literature
  ], ...;
  fhir:SubstanceDefinition.name [ # 0..* Names applicable to this substance
    fhir:SubstanceDefinition.name.name [ string ]; # 1..1 The actual name
    fhir:SubstanceDefinition.name.type [ CodeableConcept ]; # 0..1 Name type, for example 'systematic',  'scientific, 'brand'
    fhir:SubstanceDefinition.name.status [ CodeableConcept ]; # 0..1 The status of the name, for example 'current', 'proposed'
    fhir:SubstanceDefinition.name.preferred [ boolean ]; # 0..1 If this is the preferred name for this substance
    fhir:SubstanceDefinition.name.language [ CodeableConcept ], ... ; # 0..* Human language that the name is written in
    fhir:SubstanceDefinition.name.domain [ CodeableConcept ], ... ; # 0..* The use context of this name for example if there is a different name a drug active ingredient as opposed to a food colour additive
    fhir:SubstanceDefinition.name.jurisdiction [ CodeableConcept ], ... ; # 0..* The jurisdiction where this name applies
    fhir:SubstanceDefinition.name.synonym [ See SubstanceDefinition.name ], ... ; # 0..* A synonym of this particular name, by which the substance is also known
    fhir:SubstanceDefinition.name.translation [ See SubstanceDefinition.name ], ... ; # 0..* A translation for this name into another human language
    fhir:SubstanceDefinition.name.official [ # 0..* Details of the official nature of this name
      fhir:SubstanceDefinition.name.official.authority [ CodeableConcept ]; # 0..1 Which authority uses this official name
      fhir:SubstanceDefinition.name.official.status [ CodeableConcept ]; # 0..1 The status of the official name, for example 'provisional', 'approved'
      fhir:SubstanceDefinition.name.official.date [ dateTime ]; # 0..1 Date of official name change
    ], ...;
    fhir:SubstanceDefinition.name.source [ Reference(DocumentReference) ], ... ; # 0..* Supporting literature
  ], ...;
  fhir:SubstanceDefinition.molecularWeight [ See SubstanceDefinition.structure.isotope.molecularWeight ], ... ; # 0..* The molecular weight or weight range (for proteins, polymers or nucleic acids)
  fhir:SubstanceDefinition.relationship [ # 0..* A link between this substance and another, with details of the relationship
    # SubstanceDefinition.relationship.substanceDefinition[x] : 0..1 A pointer to another substance, as a resource or just a representational code. One of these 2
      fhir:SubstanceDefinition.relationship.substanceDefinitionReference [ Reference(SubstanceDefinition) ]
      fhir:SubstanceDefinition.relationship.substanceDefinitionCodeableConcept [ CodeableConcept ]
    fhir:SubstanceDefinition.relationship.type [ CodeableConcept ]; # 0..1 For example "salt to parent", "active moiety", "starting material", "polymorph"
    fhir:SubstanceDefinition.relationship.isDefining [ boolean ]; # 0..1 For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible substance relationships
    # SubstanceDefinition.relationship.amount[x] : 0..1 A numeric factor for the relationship, for instance to express that the salt of a substance has some percentage of the active substance in relation to some other. One of these 4
      fhir:SubstanceDefinition.relationship.amountQuantity [ Quantity ]
      fhir:SubstanceDefinition.relationship.amountRange [ Range ]
      fhir:SubstanceDefinition.relationship.amountRatio [ Ratio ]
      fhir:SubstanceDefinition.relationship.amountString [ string ]
    fhir:SubstanceDefinition.relationship.amountRatioHighLimit [ Ratio ]; # 0..1 For use when the numeric has an uncertain range
    fhir:SubstanceDefinition.relationship.amountType [ CodeableConcept ]; # 0..1 An operator for the amount, for example "average", "approximately", "less than"
    fhir:SubstanceDefinition.relationship.source [ Reference(DocumentReference) ], ... ; # 0..* Supporting literature
  ], ...;
  fhir:SubstanceDefinition.nucleicAcid [ Reference(SubstanceNucleicAcid) ]; # 0..1 Data items specific to nucleic acids
  fhir:SubstanceDefinition.polymer [ Reference(SubstancePolymer) ]; # 0..1 Data items specific to polymers
  fhir:SubstanceDefinition.protein [ Reference(SubstanceProtein) ]; # 0..1 Data items specific to proteins
  fhir:SubstanceDefinition.sourceMaterial [ Reference(SubstanceSourceMaterial) ]; # 0..1 Material or taxonomic/anatomical source for the substance
]

This resource did not exist in Release 2

This analysis is available as XML or JSON.

<SubstanceDefinition xmlns="http://hl7.org/fhir"> 
 <!-- from Resource: id, meta, implicitRules, and language -->
 <!-- from DomainResource: text, contained, extension, and modifierExtension -->
 <identifier><!-- 0..1 Identifier Identifier by which this substance is known --></identifier>
 <version value="[string]"/><!-- 0..1 A business level identifier of the substance -->
 <status><!-- 0..1 CodeableConcept Status of substance within the catalogue e.g. approved --></status>
 <category><!-- 0..1 CodeableConcept High level categorization, e.g. polymer or nucleic acid, or food, chemical, biological --></category>
 <domain><!-- 0..1 CodeableConcept If the substance applies to only human or veterinary use --></domain>
 <description value="[markdown]"/><!-- 0..1 Textual description of the substance -->
 <source><!-- 0..* Reference(DocumentReference) Supporting literature --></source>
 <note><!-- 0..* Annotation Textual comment about this record of a substance --></note>
 <manufacturer><!-- 0..* Reference(Organization) A company that makes this substance --></manufacturer>
 <supplier><!-- 0..* Reference(Organization) A company that supplies this substance --></supplier>
 <moiety>  <!-- 0..* Moiety, for structural modifications -->
  <role><!-- 0..1 CodeableConcept Role that the moiety is playing --></role>
  <identifier><!-- 0..1 Identifier Identifier by which this moiety substance is known --></identifier>
  <name value="[string]"/><!-- 0..1 Textual name for this moiety substance -->
  <stereochemistry><!-- 0..1 CodeableConcept Stereochemistry type --></stereochemistry>
  <opticalActivity><!-- 0..1 CodeableConcept Optical activity type --></opticalActivity>
  <molecularFormula value="[string]"/><!-- 0..1 Molecular formula for this moiety of this substance, typically using the Hill system -->
  <amount[x]><!-- 0..1 Quantity|string Quantitative value for this moiety --></amount[x]>
  <amountType><!-- 0..1 CodeableConcept The measurement type of the quantitative value --></amountType>
 </moiety>
 <property>  <!-- 0..* General specifications for this substance, including how it is related to other substances -->
  <category><!-- 0..1 CodeableConcept A category for this property, e.g. Physical, Chemical, Enzymatic --></category>
  <code><!-- 0..1 CodeableConcept Property type e.g. viscosity, pH, isoelectric point --></code>
  <parameters value="[string]"/><!-- 0..1 Parameters that were used in the measurement of a property (e.g. for viscosity: measured at 20C with a pH of 7.1) -->
  <definingSubstance[x]><!-- 0..1 Reference(Substance|SubstanceDefinition)|
    CodeableConcept A substance upon which a defining property depends (e.g. for solubility: in water, in alcohol) --></definingSubstance[x]>
  <amount[x]><!-- 0..1 Quantity|string Quantitative value for this property --></amount[x]>
  <referenceRange><!-- 0..1 Range Range of typical values --></referenceRange>
  <source><!-- 0..* Reference(DocumentReference) Supporting literature --></source>
 </property>
 <referenceInformation><!-- 0..1 Reference(SubstanceReferenceInformation) General information detailing this substance --></referenceInformation>
 <structure>  <!-- 0..1 Structural information -->
  <stereochemistry><!-- 0..1 CodeableConcept Stereochemistry type --></stereochemistry>
  <opticalActivity><!-- 0..1 CodeableConcept Optical activity type --></opticalActivity>
  <molecularFormula value="[string]"/><!-- 0..1 Molecular formula of this substance, typically using the Hill system -->
  <molecularFormulaByMoiety value="[string]"/><!-- 0..1 Specified per moiety according to the Hill system, i.e. first C, then H, then alphabetical, each moiety separated by a dot -->
  <isotope>  <!-- 0..* Applicable for single substances that contain a radionuclide or a non-natural isotopic ratio -->
   <identifier><!-- 0..1 Identifier Substance identifier for each non-natural or radioisotope --></identifier>
   <name><!-- 0..1 CodeableConcept Substance name for each non-natural or radioisotope --></name>
   <substitution><!-- 0..1 CodeableConcept The type of isotopic substitution present in a single substance --></substitution>
   <halfLife><!-- 0..1 Quantity Half life - for a non-natural nuclide --></halfLife>
   <molecularWeight>  <!-- 0..1 The molecular weight or weight range (for proteins, polymers or nucleic acids) -->
    <method><!-- 0..1 CodeableConcept The method by which the molecular weight was determined --></method>
    <type><!-- 0..1 CodeableConcept Type of molecular weight such as exact, average (also known as. number average), weight average --></type>
    <amount><!-- 0..1 Quantity Used to capture quantitative values for a variety of elements. If only limits are given, the arithmetic mean would be the average. If only a single definite value for a given element is given, it would be captured in this field --></amount>
   </molecularWeight>
  </isotope>
  <molecularWeight><!-- 0..1 Content as for SubstanceDefinition.structure.isotope.molecularWeight The molecular weight or weight range (for proteins, polymers or nucleic acids) --></molecularWeight>
  <sourceCoding><!-- 0..* Coding Describes the source of information --></sourceCoding>
  <sourceDocument><!-- 0..* Reference(DocumentReference) Supporting literature about the source of information --></sourceDocument>
  <representation>  <!-- 0..* Molecular structural representation -->
   <type><!-- 0..1 CodeableConcept The type of structure (e.g. Full, Partial, Representative) --></type>
   <representation value="[string]"/><!-- 0..1 The structural representation as text string in a format e.g. InChI, SMILES, MOLFILE, CDX -->
   <attachment><!-- 0..1 Attachment An attached file with the structural representation --></attachment>
  </representation>
 </structure>
 <code>  <!-- 0..* Codes associated with the substance -->
  <code><!-- 0..1 CodeableConcept The specific code --></code>
  <status><!-- 0..1 CodeableConcept Status of the code assignment, for example 'provisional', 'approved' --></status>
  <statusDate value="[dateTime]"/><!-- 0..1 The date at which the code status is changed as part of the terminology maintenance -->
  <note><!-- 0..* Annotation Any comment can be provided in this field, if necessary --></note>
  <source><!-- 0..* Reference(DocumentReference) Supporting literature --></source>
 </code>
 <name>  <!-- 0..* Names applicable to this substance -->
  <name value="[string]"/><!-- 1..1 The actual name -->
  <type><!-- 0..1 CodeableConcept Name type, for example 'systematic',  'scientific, 'brand' --></type>
  <status><!-- 0..1 CodeableConcept The status of the name, for example 'current', 'proposed' --></status>
  <preferred value="[boolean]"/><!-- 0..1 If this is the preferred name for this substance -->
  <language><!-- 0..* CodeableConcept Human language that the name is written in --></language>
  <domain><!-- 0..* CodeableConcept The use context of this name for example if there is a different name a drug active ingredient as opposed to a food colour additive --></domain>
  <jurisdiction><!-- 0..* CodeableConcept The jurisdiction where this name applies --></jurisdiction>
  <synonym><!-- 0..* Content as for SubstanceDefinition.name A synonym of this particular name, by which the substance is also known --></synonym>
  <translation><!-- 0..* Content as for SubstanceDefinition.name A translation for this name into another human language --></translation>
  <official>  <!-- 0..* Details of the official nature of this name -->
   <authority><!-- 0..1 CodeableConcept Which authority uses this official name --></authority>
   <status><!-- 0..1 CodeableConcept The status of the official name, for example 'provisional', 'approved' --></status>
   <date value="[dateTime]"/><!-- 0..1 Date of official name change -->
  </official>
  <source><!-- 0..* Reference(DocumentReference) Supporting literature --></source>
 </name>
 <molecularWeight><!-- 0..* Content as for SubstanceDefinition.structure.isotope.molecularWeight The molecular weight or weight range (for proteins, polymers or nucleic acids) --></molecularWeight>
 <relationship>  <!-- 0..* A link between this substance and another, with details of the relationship -->
  <substanceDefinition[x]><!-- 0..1 Reference(SubstanceDefinition)|
    CodeableConcept A pointer to another substance, as a resource or just a representational code --></substanceDefinition[x]>
  <type><!-- 0..1 CodeableConcept For example "salt to parent", "active moiety", "starting material", "polymorph" --></type>
  <isDefining value="[boolean]"/><!-- 0..1 For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible substance relationships -->
  <amount[x]><!-- 0..1 Quantity|Range|Ratio|string A numeric factor for the relationship, for instance to express that the salt of a substance has some percentage of the active substance in relation to some other --></amount[x]>
  <amountRatioHighLimit><!-- 0..1 Ratio For use when the numeric has an uncertain range --></amountRatioHighLimit>
  <amountType><!-- 0..1 CodeableConcept An operator for the amount, for example "average", "approximately", "less than" --></amountType>
  <source><!-- 0..* Reference(DocumentReference) Supporting literature --></source>
 </relationship>
 <nucleicAcid><!-- 0..1 Reference(SubstanceNucleicAcid) Data items specific to nucleic acids --></nucleicAcid>
 <polymer><!-- 0..1 Reference(SubstancePolymer) Data items specific to polymers --></polymer>
 <protein><!-- 0..1 Reference(SubstanceProtein) Data items specific to proteins --></protein>
 <sourceMaterial><!-- 0..1 Reference(SubstanceSourceMaterial) Material or taxonomic/anatomical source for the substance --></sourceMaterial>
</SubstanceDefinition>

{
  "resourceType" : "SubstanceDefinition",
  // from Resource: id, meta, implicitRules, and language
  // from DomainResource: text, contained, extension, and modifierExtension
  "identifier" : { Identifier }, // Identifier by which this substance is known
  "version" : "<string>", // A business level identifier of the substance
  "status" : { CodeableConcept }, // Status of substance within the catalogue e.g. approved
  "category" : { CodeableConcept }, // High level categorization, e.g. polymer or nucleic acid, or food, chemical, biological
  "domain" : { CodeableConcept }, // If the substance applies to only human or veterinary use
  "description" : "<markdown>", // Textual description of the substance
  "source" : [{ Reference(DocumentReference) }], // Supporting literature
  "note" : [{ Annotation }], // Textual comment about this record of a substance
  "manufacturer" : [{ Reference(Organization) }], // A company that makes this substance
  "supplier" : [{ Reference(Organization) }], // A company that supplies this substance
  "moiety" : [{ // Moiety, for structural modifications
    "role" : { CodeableConcept }, // Role that the moiety is playing
    "identifier" : { Identifier }, // Identifier by which this moiety substance is known
    "name" : "<string>", // Textual name for this moiety substance
    "stereochemistry" : { CodeableConcept }, // Stereochemistry type
    "opticalActivity" : { CodeableConcept }, // Optical activity type
    "molecularFormula" : "<string>", // Molecular formula for this moiety of this substance, typically using the Hill system
    // amount[x]: Quantitative value for this moiety. One of these 2:
    "amountQuantity" : { Quantity },
    "amountString" : "<string>",
    "amountType" : { CodeableConcept } // The measurement type of the quantitative value
  }],
  "property" : [{ // General specifications for this substance, including how it is related to other substances
    "category" : { CodeableConcept }, // A category for this property, e.g. Physical, Chemical, Enzymatic
    "code" : { CodeableConcept }, // Property type e.g. viscosity, pH, isoelectric point
    "parameters" : "<string>", // Parameters that were used in the measurement of a property (e.g. for viscosity: measured at 20C with a pH of 7.1)
    // definingSubstance[x]: 
      A substance upon which a defining property depends (e.g. for solubility: in water, in alcohol). One of these 2:
    "definingSubstanceReference" : { Reference(Substance|SubstanceDefinition) },
    "definingSubstanceCodeableConcept" : { CodeableConcept },
    // amount[x]: Quantitative value for this property. One of these 2:
    "amountQuantity" : { Quantity },
    "amountString" : "<string>",
    "referenceRange" : { Range }, // Range of typical values
    "source" : [{ Reference(DocumentReference) }] // Supporting literature
  }],
  "referenceInformation" : { Reference(SubstanceReferenceInformation) }, // General information detailing this substance
  "structure" : { // Structural information
    "stereochemistry" : { CodeableConcept }, // Stereochemistry type
    "opticalActivity" : { CodeableConcept }, // Optical activity type
    "molecularFormula" : "<string>", // Molecular formula of this substance, typically using the Hill system
    "molecularFormulaByMoiety" : "<string>", // Specified per moiety according to the Hill system, i.e. first C, then H, then alphabetical, each moiety separated by a dot
    "isotope" : [{ // Applicable for single substances that contain a radionuclide or a non-natural isotopic ratio
      "identifier" : { Identifier }, // Substance identifier for each non-natural or radioisotope
      "name" : { CodeableConcept }, // Substance name for each non-natural or radioisotope
      "substitution" : { CodeableConcept }, // The type of isotopic substitution present in a single substance
      "halfLife" : { Quantity }, // Half life - for a non-natural nuclide
      "molecularWeight" : { // The molecular weight or weight range (for proteins, polymers or nucleic acids)
        "method" : { CodeableConcept }, // The method by which the molecular weight was determined
        "type" : { CodeableConcept }, // Type of molecular weight such as exact, average (also known as. number average), weight average
        "amount" : { Quantity } // Used to capture quantitative values for a variety of elements. If only limits are given, the arithmetic mean would be the average. If only a single definite value for a given element is given, it would be captured in this field
      }
    }],
    "molecularWeight" : { Content as for SubstanceDefinition.structure.isotope.molecularWeight }, // The molecular weight or weight range (for proteins, polymers or nucleic acids)
    "sourceCoding" : [{ Coding }], // Describes the source of information
    "sourceDocument" : [{ Reference(DocumentReference) }], // Supporting literature about the source of information
    "representation" : [{ // Molecular structural representation
      "type" : { CodeableConcept }, // The type of structure (e.g. Full, Partial, Representative)
      "representation" : "<string>", // The structural representation as text string in a format e.g. InChI, SMILES, MOLFILE, CDX
      "attachment" : { Attachment } // An attached file with the structural representation
    }]
  },
  "code" : [{ // Codes associated with the substance
    "code" : { CodeableConcept }, // The specific code
    "status" : { CodeableConcept }, // Status of the code assignment, for example 'provisional', 'approved'
    "statusDate" : "<dateTime>", // The date at which the code status is changed as part of the terminology maintenance
    "note" : [{ Annotation }], // Any comment can be provided in this field, if necessary
    "source" : [{ Reference(DocumentReference) }] // Supporting literature
  }],
  "name" : [{ // Names applicable to this substance
    "name" : "<string>", // R!  The actual name
    "type" : { CodeableConcept }, // Name type, for example 'systematic',  'scientific, 'brand'
    "status" : { CodeableConcept }, // The status of the name, for example 'current', 'proposed'
    "preferred" : <boolean>, // If this is the preferred name for this substance
    "language" : [{ CodeableConcept }], // Human language that the name is written in
    "domain" : [{ CodeableConcept }], // The use context of this name for example if there is a different name a drug active ingredient as opposed to a food colour additive
    "jurisdiction" : [{ CodeableConcept }], // The jurisdiction where this name applies
    "synonym" : [{ Content as for SubstanceDefinition.name }], // A synonym of this particular name, by which the substance is also known
    "translation" : [{ Content as for SubstanceDefinition.name }], // A translation for this name into another human language
    "official" : [{ // Details of the official nature of this name
      "authority" : { CodeableConcept }, // Which authority uses this official name
      "status" : { CodeableConcept }, // The status of the official name, for example 'provisional', 'approved'
      "date" : "<dateTime>" // Date of official name change
    }],
    "source" : [{ Reference(DocumentReference) }] // Supporting literature
  }],
  "molecularWeight" : [{ Content as for SubstanceDefinition.structure.isotope.molecularWeight }], // The molecular weight or weight range (for proteins, polymers or nucleic acids)
  "relationship" : [{ // A link between this substance and another, with details of the relationship
    // substanceDefinition[x]: 
      A pointer to another substance, as a resource or just a representational code. One of these 2:
    "substanceDefinitionReference" : { Reference(SubstanceDefinition) },
    "substanceDefinitionCodeableConcept" : { CodeableConcept },
    "type" : { CodeableConcept }, // For example "salt to parent", "active moiety", "starting material", "polymorph"
    "isDefining" : <boolean>, // For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible substance relationships
    // amount[x]: 
      A numeric factor for the relationship, for instance to express that the salt of a substance has some percentage of the active substance in relation to some other. One of these 4:
    "amountQuantity" : { Quantity },
    "amountRange" : { Range },
    "amountRatio" : { Ratio },
    "amountString" : "<string>",
    "amountRatioHighLimit" : { Ratio }, // For use when the numeric has an uncertain range
    "amountType" : { CodeableConcept }, // An operator for the amount, for example "average", "approximately", "less than"
    "source" : [{ Reference(DocumentReference) }] // Supporting literature
  }],
  "nucleicAcid" : { Reference(SubstanceNucleicAcid) }, // Data items specific to nucleic acids
  "polymer" : { Reference(SubstancePolymer) }, // Data items specific to polymers
  "protein" : { Reference(SubstanceProtein) }, // Data items specific to proteins
  "sourceMaterial" : { Reference(SubstanceSourceMaterial) } // Material or taxonomic/anatomical source for the substance
}

@prefix fhir: <http://hl7.org/fhir/> .


[ a fhir:SubstanceDefinition;
  fhir:nodeRole fhir:treeRoot; # if this is the parser root

  # from Resource: .id, .meta, .implicitRules, and .language
  # from DomainResource: .text, .contained, .extension, and .modifierExtension
  fhir:SubstanceDefinition.identifier [ Identifier ]; # 0..1 Identifier by which this substance is known
  fhir:SubstanceDefinition.version [ string ]; # 0..1 A business level identifier of the substance
  fhir:SubstanceDefinition.status [ CodeableConcept ]; # 0..1 Status of substance within the catalogue e.g. approved
  fhir:SubstanceDefinition.category [ CodeableConcept ]; # 0..1 High level categorization, e.g. polymer or nucleic acid, or food, chemical, biological
  fhir:SubstanceDefinition.domain [ CodeableConcept ]; # 0..1 If the substance applies to only human or veterinary use
  fhir:SubstanceDefinition.description [ markdown ]; # 0..1 Textual description of the substance
  fhir:SubstanceDefinition.source [ Reference(DocumentReference) ], ... ; # 0..* Supporting literature
  fhir:SubstanceDefinition.note [ Annotation ], ... ; # 0..* Textual comment about this record of a substance
  fhir:SubstanceDefinition.manufacturer [ Reference(Organization) ], ... ; # 0..* A company that makes this substance
  fhir:SubstanceDefinition.supplier [ Reference(Organization) ], ... ; # 0..* A company that supplies this substance
  fhir:SubstanceDefinition.moiety [ # 0..* Moiety, for structural modifications
    fhir:SubstanceDefinition.moiety.role [ CodeableConcept ]; # 0..1 Role that the moiety is playing
    fhir:SubstanceDefinition.moiety.identifier [ Identifier ]; # 0..1 Identifier by which this moiety substance is known
    fhir:SubstanceDefinition.moiety.name [ string ]; # 0..1 Textual name for this moiety substance
    fhir:SubstanceDefinition.moiety.stereochemistry [ CodeableConcept ]; # 0..1 Stereochemistry type
    fhir:SubstanceDefinition.moiety.opticalActivity [ CodeableConcept ]; # 0..1 Optical activity type
    fhir:SubstanceDefinition.moiety.molecularFormula [ string ]; # 0..1 Molecular formula for this moiety of this substance, typically using the Hill system
    # SubstanceDefinition.moiety.amount[x] : 0..1 Quantitative value for this moiety. One of these 2
      fhir:SubstanceDefinition.moiety.amountQuantity [ Quantity ]
      fhir:SubstanceDefinition.moiety.amountString [ string ]
    fhir:SubstanceDefinition.moiety.amountType [ CodeableConcept ]; # 0..1 The measurement type of the quantitative value
  ], ...;
  fhir:SubstanceDefinition.property [ # 0..* General specifications for this substance, including how it is related to other substances
    fhir:SubstanceDefinition.property.category [ CodeableConcept ]; # 0..1 A category for this property, e.g. Physical, Chemical, Enzymatic
    fhir:SubstanceDefinition.property.code [ CodeableConcept ]; # 0..1 Property type e.g. viscosity, pH, isoelectric point
    fhir:SubstanceDefinition.property.parameters [ string ]; # 0..1 Parameters that were used in the measurement of a property (e.g. for viscosity: measured at 20C with a pH of 7.1)
    # SubstanceDefinition.property.definingSubstance[x] : 0..1 A substance upon which a defining property depends (e.g. for solubility: in water, in alcohol). One of these 2
      fhir:SubstanceDefinition.property.definingSubstanceReference [ Reference(Substance|SubstanceDefinition) ]
      fhir:SubstanceDefinition.property.definingSubstanceCodeableConcept [ CodeableConcept ]
    # SubstanceDefinition.property.amount[x] : 0..1 Quantitative value for this property. One of these 2
      fhir:SubstanceDefinition.property.amountQuantity [ Quantity ]
      fhir:SubstanceDefinition.property.amountString [ string ]
    fhir:SubstanceDefinition.property.referenceRange [ Range ]; # 0..1 Range of typical values
    fhir:SubstanceDefinition.property.source [ Reference(DocumentReference) ], ... ; # 0..* Supporting literature
  ], ...;
  fhir:SubstanceDefinition.referenceInformation [ Reference(SubstanceReferenceInformation) ]; # 0..1 General information detailing this substance
  fhir:SubstanceDefinition.structure [ # 0..1 Structural information
    fhir:SubstanceDefinition.structure.stereochemistry [ CodeableConcept ]; # 0..1 Stereochemistry type
    fhir:SubstanceDefinition.structure.opticalActivity [ CodeableConcept ]; # 0..1 Optical activity type
    fhir:SubstanceDefinition.structure.molecularFormula [ string ]; # 0..1 Molecular formula of this substance, typically using the Hill system
    fhir:SubstanceDefinition.structure.molecularFormulaByMoiety [ string ]; # 0..1 Specified per moiety according to the Hill system, i.e. first C, then H, then alphabetical, each moiety separated by a dot
    fhir:SubstanceDefinition.structure.isotope [ # 0..* Applicable for single substances that contain a radionuclide or a non-natural isotopic ratio
      fhir:SubstanceDefinition.structure.isotope.identifier [ Identifier ]; # 0..1 Substance identifier for each non-natural or radioisotope
      fhir:SubstanceDefinition.structure.isotope.name [ CodeableConcept ]; # 0..1 Substance name for each non-natural or radioisotope
      fhir:SubstanceDefinition.structure.isotope.substitution [ CodeableConcept ]; # 0..1 The type of isotopic substitution present in a single substance
      fhir:SubstanceDefinition.structure.isotope.halfLife [ Quantity ]; # 0..1 Half life - for a non-natural nuclide
      fhir:SubstanceDefinition.structure.isotope.molecularWeight [ # 0..1 The molecular weight or weight range (for proteins, polymers or nucleic acids)
        fhir:SubstanceDefinition.structure.isotope.molecularWeight.method [ CodeableConcept ]; # 0..1 The method by which the molecular weight was determined
        fhir:SubstanceDefinition.structure.isotope.molecularWeight.type [ CodeableConcept ]; # 0..1 Type of molecular weight such as exact, average (also known as. number average), weight average
        fhir:SubstanceDefinition.structure.isotope.molecularWeight.amount [ Quantity ]; # 0..1 Used to capture quantitative values for a variety of elements. If only limits are given, the arithmetic mean would be the average. If only a single definite value for a given element is given, it would be captured in this field
      ];
    ], ...;
    fhir:SubstanceDefinition.structure.molecularWeight [ See SubstanceDefinition.structure.isotope.molecularWeight ]; # 0..1 The molecular weight or weight range (for proteins, polymers or nucleic acids)
    fhir:SubstanceDefinition.structure.sourceCoding [ Coding ], ... ; # 0..* Describes the source of information
    fhir:SubstanceDefinition.structure.sourceDocument [ Reference(DocumentReference) ], ... ; # 0..* Supporting literature about the source of information
    fhir:SubstanceDefinition.structure.representation [ # 0..* Molecular structural representation
      fhir:SubstanceDefinition.structure.representation.type [ CodeableConcept ]; # 0..1 The type of structure (e.g. Full, Partial, Representative)
      fhir:SubstanceDefinition.structure.representation.representation [ string ]; # 0..1 The structural representation as text string in a format e.g. InChI, SMILES, MOLFILE, CDX
      fhir:SubstanceDefinition.structure.representation.attachment [ Attachment ]; # 0..1 An attached file with the structural representation
    ], ...;
  ];
  fhir:SubstanceDefinition.code [ # 0..* Codes associated with the substance
    fhir:SubstanceDefinition.code.code [ CodeableConcept ]; # 0..1 The specific code
    fhir:SubstanceDefinition.code.status [ CodeableConcept ]; # 0..1 Status of the code assignment, for example 'provisional', 'approved'
    fhir:SubstanceDefinition.code.statusDate [ dateTime ]; # 0..1 The date at which the code status is changed as part of the terminology maintenance
    fhir:SubstanceDefinition.code.note [ Annotation ], ... ; # 0..* Any comment can be provided in this field, if necessary
    fhir:SubstanceDefinition.code.source [ Reference(DocumentReference) ], ... ; # 0..* Supporting literature
  ], ...;
  fhir:SubstanceDefinition.name [ # 0..* Names applicable to this substance
    fhir:SubstanceDefinition.name.name [ string ]; # 1..1 The actual name
    fhir:SubstanceDefinition.name.type [ CodeableConcept ]; # 0..1 Name type, for example 'systematic',  'scientific, 'brand'
    fhir:SubstanceDefinition.name.status [ CodeableConcept ]; # 0..1 The status of the name, for example 'current', 'proposed'
    fhir:SubstanceDefinition.name.preferred [ boolean ]; # 0..1 If this is the preferred name for this substance
    fhir:SubstanceDefinition.name.language [ CodeableConcept ], ... ; # 0..* Human language that the name is written in
    fhir:SubstanceDefinition.name.domain [ CodeableConcept ], ... ; # 0..* The use context of this name for example if there is a different name a drug active ingredient as opposed to a food colour additive
    fhir:SubstanceDefinition.name.jurisdiction [ CodeableConcept ], ... ; # 0..* The jurisdiction where this name applies
    fhir:SubstanceDefinition.name.synonym [ See SubstanceDefinition.name ], ... ; # 0..* A synonym of this particular name, by which the substance is also known
    fhir:SubstanceDefinition.name.translation [ See SubstanceDefinition.name ], ... ; # 0..* A translation for this name into another human language
    fhir:SubstanceDefinition.name.official [ # 0..* Details of the official nature of this name
      fhir:SubstanceDefinition.name.official.authority [ CodeableConcept ]; # 0..1 Which authority uses this official name
      fhir:SubstanceDefinition.name.official.status [ CodeableConcept ]; # 0..1 The status of the official name, for example 'provisional', 'approved'
      fhir:SubstanceDefinition.name.official.date [ dateTime ]; # 0..1 Date of official name change
    ], ...;
    fhir:SubstanceDefinition.name.source [ Reference(DocumentReference) ], ... ; # 0..* Supporting literature
  ], ...;
  fhir:SubstanceDefinition.molecularWeight [ See SubstanceDefinition.structure.isotope.molecularWeight ], ... ; # 0..* The molecular weight or weight range (for proteins, polymers or nucleic acids)
  fhir:SubstanceDefinition.relationship [ # 0..* A link between this substance and another, with details of the relationship
    # SubstanceDefinition.relationship.substanceDefinition[x] : 0..1 A pointer to another substance, as a resource or just a representational code. One of these 2
      fhir:SubstanceDefinition.relationship.substanceDefinitionReference [ Reference(SubstanceDefinition) ]
      fhir:SubstanceDefinition.relationship.substanceDefinitionCodeableConcept [ CodeableConcept ]
    fhir:SubstanceDefinition.relationship.type [ CodeableConcept ]; # 0..1 For example "salt to parent", "active moiety", "starting material", "polymorph"
    fhir:SubstanceDefinition.relationship.isDefining [ boolean ]; # 0..1 For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible substance relationships
    # SubstanceDefinition.relationship.amount[x] : 0..1 A numeric factor for the relationship, for instance to express that the salt of a substance has some percentage of the active substance in relation to some other. One of these 4
      fhir:SubstanceDefinition.relationship.amountQuantity [ Quantity ]
      fhir:SubstanceDefinition.relationship.amountRange [ Range ]
      fhir:SubstanceDefinition.relationship.amountRatio [ Ratio ]
      fhir:SubstanceDefinition.relationship.amountString [ string ]
    fhir:SubstanceDefinition.relationship.amountRatioHighLimit [ Ratio ]; # 0..1 For use when the numeric has an uncertain range
    fhir:SubstanceDefinition.relationship.amountType [ CodeableConcept ]; # 0..1 An operator for the amount, for example "average", "approximately", "less than"
    fhir:SubstanceDefinition.relationship.source [ Reference(DocumentReference) ], ... ; # 0..* Supporting literature
  ], ...;
  fhir:SubstanceDefinition.nucleicAcid [ Reference(SubstanceNucleicAcid) ]; # 0..1 Data items specific to nucleic acids
  fhir:SubstanceDefinition.polymer [ Reference(SubstancePolymer) ]; # 0..1 Data items specific to polymers
  fhir:SubstanceDefinition.protein [ Reference(SubstanceProtein) ]; # 0..1 Data items specific to proteins
  fhir:SubstanceDefinition.sourceMaterial [ Reference(SubstanceSourceMaterial) ]; # 0..1 Material or taxonomic/anatomical source for the substance
]

This resource did not exist in Release 2

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