Extensions for Using Data Elements from FHIR R5 in FHIR R4B - Downloaded Version null See the Directory of published versions

• Content
• Detailed Descriptions
• XML
• JSON
• TTL

Resource Profile: Profile_R5_SubstanceDefinition_R4B

This cross-version profile allows R5 SubstanceDefinition content to be represented via FHIR R4B SubstanceDefinition resources.

Usages:

• Refer to this Profile: R5: focus additional types and R5: code additional types

You can also check for usages in the FHIR IG Statistics

Formal Views of Profile Content

Description of Profiles, Differentials, Snapshots and how the different presentations work.

• Key Elements Table
• Differential Table
• Snapshot Table
• Statistics/References
• All

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
SubstanceDefinition		0..*	SubstanceDefinition(4.3.0)	The detailed description of a substance, typically at a level beyond what is used for prescribing
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url Constraints: ext-1
extension:characterization		0..*	(Complex)	R5: General specifications for this substance (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.characterization Constraints: ext-1
extension:referenceInformation		0..1	Reference(Cross-version Profile for R5.SubstanceReferenceInformation for use in FHIR R4B(0.1.0) | Basic)	R5: General information detailing this substance (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.referenceInformation Constraints: ext-1
extension:nucleicAcid		0..1	Reference(Cross-version Profile for R5.SubstanceNucleicAcid for use in FHIR R4B(0.1.0) | Basic)	R5: Data items specific to nucleic acids (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.nucleicAcid Constraints: ext-1
extension:polymer		0..1	Reference(Cross-version Profile for R5.SubstancePolymer for use in FHIR R4B(0.1.0) | Basic)	R5: Data items specific to polymers (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.polymer Constraints: ext-1
extension:protein		0..1	Reference(Cross-version Profile for R5.SubstanceProtein for use in FHIR R4B(0.1.0) | Basic)	R5: Data items specific to proteins (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.protein Constraints: ext-1
modifierExtension	?!	0..*	Extension	Extensions that cannot be ignored Constraints: ext-1
Documentation for this format

Constraints

Id	Grade	Path(s)	Description	Expression
dom-2	error	SubstanceDefinition	If the resource is contained in another resource, it SHALL NOT contain nested Resources	contained.contained.empty()
dom-3	error	SubstanceDefinition	If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource	contained.where(((id.exists() and ('#'+id in (%resource.descendants().reference | %resource.descendants().as(canonical) | %resource.descendants().as(uri) | %resource.descendants().as(url)))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(uri) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4	error	SubstanceDefinition	If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated	contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5	error	SubstanceDefinition	If a resource is contained in another resource, it SHALL NOT have a security label	contained.meta.security.empty()
dom-6	best practice	SubstanceDefinition	A resource should have narrative for robust management	text.`div`.exists()
ele-1	error	SubstanceDefinition.implicitRules, SubstanceDefinition.extension, SubstanceDefinition.extension:characterization, SubstanceDefinition.extension:referenceInformation, SubstanceDefinition.extension:nucleicAcid, SubstanceDefinition.extension:polymer, SubstanceDefinition.extension:protein, SubstanceDefinition.modifierExtension	All FHIR elements must have a @value or children	hasValue() or (children().count() > id.count())
ext-1	error	SubstanceDefinition.extension, SubstanceDefinition.extension:characterization, SubstanceDefinition.extension:referenceInformation, SubstanceDefinition.extension:nucleicAcid, SubstanceDefinition.extension:polymer, SubstanceDefinition.extension:protein, SubstanceDefinition.modifierExtension	Must have either extensions or value[x], not both	extension.exists() != value.exists()

This structure is derived from SubstanceDefinition

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
SubstanceDefinition		0..*	SubstanceDefinition(4.3.0)	The detailed description of a substance, typically at a level beyond what is used for prescribing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:characterization		0..*	(Complex)	R5: General specifications for this substance (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.characterization
extension:referenceInformation		0..1	Reference(Cross-version Profile for R5.SubstanceReferenceInformation for use in FHIR R4B(0.1.0) | Basic)	R5: General information detailing this substance (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.referenceInformation
extension:nucleicAcid		0..1	Reference(Cross-version Profile for R5.SubstanceNucleicAcid for use in FHIR R4B(0.1.0) | Basic)	R5: Data items specific to nucleic acids (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.nucleicAcid
extension:polymer		0..1	Reference(Cross-version Profile for R5.SubstancePolymer for use in FHIR R4B(0.1.0) | Basic)	R5: Data items specific to polymers (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.polymer
extension:protein		0..1	Reference(Cross-version Profile for R5.SubstanceProtein for use in FHIR R4B(0.1.0) | Basic)	R5: Data items specific to proteins (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.protein
identifier
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:identifier		0..*	Identifier	R5: identifier URL: http://hl7.org/fhir/StructureDefinition/artifact-identifier
version
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:version		0..1	string	R5: version URL: http://hl7.org/fhir/StructureDefinition/artifact-version
status
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:status		0..1	code	R5: status URL: http://hl7.org/fhir/StructureDefinition/artifact-status Binding: PublicationStatus (required): The lifecycle status of an artifact.
description
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:description		0..1	markdown	R5: description URL: http://hl7.org/fhir/StructureDefinition/artifact-description
structure
sourceDocument
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:sourceDocument		0..*	Reference(Resource)	R5: sourceDocument additional types URL: http://hl7.org/fhir/StructureDefinition/alternate-reference
representation
document
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:document		0..1	Reference(Resource)	R5: document additional types URL: http://hl7.org/fhir/StructureDefinition/alternate-reference
code
source
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:source		0..*	Reference(Resource)	R5: source additional types URL: http://hl7.org/fhir/StructureDefinition/alternate-reference
name
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:name		0..*	string	R5: name URL: http://hl7.org/fhir/StructureDefinition/artifact-name
source
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:source		0..*	Reference(Resource)	R5: source additional types URL: http://hl7.org/fhir/StructureDefinition/alternate-reference
relationship
source
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:source		0..*	Reference(Resource)	R5: source additional types URL: http://hl7.org/fhir/StructureDefinition/alternate-reference
Documentation for this format

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
SubstanceDefinition		0..*	SubstanceDefinition(4.3.0)	The detailed description of a substance, typically at a level beyond what is used for prescribing
id	Σ	0..1	id	Logical id of this artifact
meta	Σ	0..1	Meta	Metadata about the resource
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
language		0..1	code	Language of the resource content Binding: CommonLanguages (preferred): IETF language tag Additional Bindings Purpose AllLanguages Max Binding
text		0..1	Narrative	Text summary of the resource, for human interpretation This profile does not constrain the narrative in regard to content, language, or traceability to data elements
contained		0..*	Resource	Contained, inline Resources Constraints: dom-r4b
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url Constraints: ext-1
extension:characterization		0..*	(Complex)	R5: General specifications for this substance (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.characterization Constraints: ext-1
extension:referenceInformation		0..1	Reference(Cross-version Profile for R5.SubstanceReferenceInformation for use in FHIR R4B(0.1.0) | Basic)	R5: General information detailing this substance (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.referenceInformation Constraints: ext-1
extension:nucleicAcid		0..1	Reference(Cross-version Profile for R5.SubstanceNucleicAcid for use in FHIR R4B(0.1.0) | Basic)	R5: Data items specific to nucleic acids (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.nucleicAcid Constraints: ext-1
extension:polymer		0..1	Reference(Cross-version Profile for R5.SubstancePolymer for use in FHIR R4B(0.1.0) | Basic)	R5: Data items specific to polymers (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.polymer Constraints: ext-1
extension:protein		0..1	Reference(Cross-version Profile for R5.SubstanceProtein for use in FHIR R4B(0.1.0) | Basic)	R5: Data items specific to proteins (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.protein Constraints: ext-1
modifierExtension	?!	0..*	Extension	Extensions that cannot be ignored Constraints: ext-1
identifier	Σ	0..*	Identifier	Identifier by which this substance is known
id		0..1	id	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url Constraints: ext-1
extension:identifier		0..*	Identifier	R5: identifier URL: http://hl7.org/fhir/StructureDefinition/artifact-identifier Constraints: ext-1
use	?!Σ	0..1	code	usual | official | temp | secondary | old (If known) Binding: IdentifierUse (required)
type	Σ	0..1	CodeableConcept	Description of identifier Binding: Identifier Type Codes (extensible)
system	Σ	0..1	uri	The namespace for the identifier value Example General: http://www.acme.com/identifiers/patient
value	Σ	0..1	string	The value that is unique Example General: 123456
period	Σ	0..1	Period	Time period when id is/was valid for use
assigner	Σ	0..1	Reference(Organization)	Organization that issued id (may be just text)
version	Σ	0..1	string	A business level version identifier of the substance
id		0..1	string	xml:id (or equivalent in JSON)
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url Constraints: ext-1
extension:version		0..1	string	R5: version URL: http://hl7.org/fhir/StructureDefinition/artifact-version Constraints: ext-1
value		0..1	string	Primitive value for string Max Length:1048576
status	Σ	0..1	CodeableConcept	Status of substance within the catalogue e.g. active, retired Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
id		0..1	id	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url Constraints: ext-1
extension:status		0..1	code	R5: status URL: http://hl7.org/fhir/StructureDefinition/artifact-status Binding: PublicationStatus (required): The lifecycle status of an artifact. Constraints: ext-1
coding	Σ	0..*	Coding	Code defined by a terminology system
text	Σ	0..1	string	Plain text representation of the concept
classification	Σ	0..*	CodeableConcept	A categorization, high level e.g. polymer or nucleic acid, or food, chemical, biological, or lower e.g. polymer linear or branch chain, or type of impurity
domain	Σ	0..1	CodeableConcept	If the substance applies to human or veterinary use Binding: MedicinalProductDomain (example): Applicable domain for this product (e.g. human, veterinary).
grade	Σ	0..*	CodeableConcept	The quality standard, established benchmark, to which substance complies (e.g. USP/NF, BP) Binding: SubstanceGrade (example): The quality standard, established benchmark, to which a substance complies
description	Σ	0..1	markdown	Textual description of the substance
id		0..1	string	xml:id (or equivalent in JSON)
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url Constraints: ext-1
extension:description		0..1	markdown	R5: description URL: http://hl7.org/fhir/StructureDefinition/artifact-description Constraints: ext-1
value		0..1	markdown	Primitive value for markdown
informationSource	Σ	0..*	Reference(Citation)	Supporting literature
note	Σ	0..*	Annotation	Textual comment about the substance's catalogue or registry record
manufacturer	Σ	0..*	Reference(Organization)	The entity that creates, makes, produces or fabricates the substance
supplier	Σ	0..*	Reference(Organization)	An entity that is the source for the substance. It may be different from the manufacturer
moiety	Σ	0..*	BackboneElement	Moiety, for structural modifications
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Constraints: ext-1
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized Constraints: ext-1
role	Σ	0..1	CodeableConcept	Role that the moiety is playing
identifier	Σ	0..1	Identifier	Identifier by which this moiety substance is known
name	Σ	0..1	string	Textual name for this moiety substance
stereochemistry	Σ	0..1	CodeableConcept	Stereochemistry type Binding: Stereochemistry (example): The optical rotation type of a substance.
opticalActivity	Σ	0..1	CodeableConcept	Optical activity type Binding: OpticalActivity (example): The optical rotation type of a substance.
molecularFormula	Σ	0..1	string	Molecular formula for this moiety (e.g. with the Hill system)
amount[x]	Σ	0..1		Quantitative value for this moiety
amountQuantity			Quantity
amountString			string
measurementType	Σ	0..1	CodeableConcept	The measurement type of the quantitative value Binding: SubstanceAmountType (example): The relationship between two substance types.
property	Σ	0..*	BackboneElement	General specifications for this substance
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Constraints: ext-1
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized Constraints: ext-1
type	Σ	1..1	CodeableConcept	A code expressing the type of property Binding: product-characteristic-codes (??) (example): This value set includes all observable entity codes from SNOMED CT - provided as an exemplar value set.
value[x]	Σ	0..1		A value for the property
valueCodeableConcept			CodeableConcept
valueQuantity			Quantity
valueDate			date
valueBoolean			boolean
valueAttachment			Attachment
molecularWeight	Σ	0..*	BackboneElement	The molecular weight or weight range
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Constraints: ext-1
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized Constraints: ext-1
method	Σ	0..1	CodeableConcept	The method by which the weight was determined Binding: WeightMethod (example): The method by which the substance weight was measured.
type	Σ	0..1	CodeableConcept	Type of molecular weight e.g. exact, average, weight average Binding: WeightType (example): The type of substance weight measurement.
amount	Σ	1..1	Quantity	Used to capture quantitative values for a variety of elements
structure	Σ	0..1	BackboneElement	Structural information
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Constraints: ext-1
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized Constraints: ext-1
stereochemistry	Σ	0..1	CodeableConcept	Stereochemistry type Binding: Stereochemistry (example): The optical rotation type of a substance.
opticalActivity	Σ	0..1	CodeableConcept	Optical activity type Binding: OpticalActivity (example): The optical rotation type of a substance.
molecularFormula	Σ	0..1	string	Molecular formula (e.g. using the Hill system)
molecularFormulaByMoiety	Σ	0..1	string	Specified per moiety according to the Hill system
molecularWeight	Σ	0..1	See molecularWeight (SubstanceDefinition)	The molecular weight or weight range
technique	Σ	0..*	CodeableConcept	The method used to find the structure e.g. X-ray, NMR Binding: StructureTechnique (example): The method used to elucidate the structure or characterization of the drug substance.
sourceDocument	Σ	0..*	Reference(DocumentReference)	Source of information for the structure
id		0..1	id	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url Constraints: ext-1
extension:sourceDocument		0..1	Reference(Resource)	R5: sourceDocument additional types URL: http://hl7.org/fhir/StructureDefinition/alternate-reference Constraints: ext-1
reference	ΣC	0..1	string	Literal reference, Relative, internal or absolute URL
type	Σ	0..1	uri	Type the reference refers to (e.g. "Patient") Binding: ResourceType (extensible)
identifier	Σ	0..1	Identifier	Logical reference, when literal reference is not known
display	Σ	0..1	string	Text alternative for the resource
representation	Σ	0..*	BackboneElement	A depiction of the structure or characterization of the substance
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Constraints: ext-1
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized Constraints: ext-1
type	Σ	0..1	CodeableConcept	The kind of structural representation (e.g. full, partial) Binding: SubstanceRepresentationType (example): A format of a substance representation.
representation	Σ	0..1	string	The structural representation or characterization as a text string in a standard format
format	Σ	0..1	CodeableConcept	The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format) Binding: SubstanceRepresentationFormat (example): A format of a substance representation.
document	Σ	0..1	Reference(DocumentReference)	An attachment with the structural representation e.g. a structure graphic or AnIML file
id		0..1	id	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url Constraints: ext-1
extension:document		0..1	Reference(Resource)	R5: document additional types URL: http://hl7.org/fhir/StructureDefinition/alternate-reference Constraints: ext-1
reference	ΣC	0..1	string	Literal reference, Relative, internal or absolute URL
type	Σ	0..1	uri	Type the reference refers to (e.g. "Patient") Binding: ResourceType (extensible)
identifier	Σ	0..1	Identifier	Logical reference, when literal reference is not known
display	Σ	0..1	string	Text alternative for the resource
code	Σ	0..*	BackboneElement	Codes associated with the substance
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Constraints: ext-1
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized Constraints: ext-1
code	Σ	0..1	CodeableConcept	The specific code
status	Σ	0..1	CodeableConcept	Status of the code assignment, for example 'provisional', 'approved' Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
statusDate	Σ	0..1	dateTime	The date at which the code status was changed
note	Σ	0..*	Annotation	Any comment can be provided in this field
source	Σ	0..*	Reference(DocumentReference)	Supporting literature
id		0..1	id	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url Constraints: ext-1
extension:source		0..1	Reference(Resource)	R5: source additional types URL: http://hl7.org/fhir/StructureDefinition/alternate-reference Constraints: ext-1
reference	ΣC	0..1	string	Literal reference, Relative, internal or absolute URL
type	Σ	0..1	uri	Type the reference refers to (e.g. "Patient") Binding: ResourceType (extensible)
identifier	Σ	0..1	Identifier	Logical reference, when literal reference is not known
display	Σ	0..1	string	Text alternative for the resource
name	Σ	0..*	BackboneElement	Names applicable to this substance
id		0..1	string	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url Constraints: ext-1
extension:name		0..*	string	R5: name URL: http://hl7.org/fhir/StructureDefinition/artifact-name Constraints: ext-1
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized Constraints: ext-1
name	Σ	1..1	string	The actual name
type	Σ	0..1	CodeableConcept	Name type e.g. 'systematic', 'scientific, 'brand' Binding: SubstanceNameType (example): The type of a name given to a substance.
status	Σ	0..1	CodeableConcept	The status of the name e.g. 'current', 'proposed' Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
preferred	Σ	0..1	boolean	If this is the preferred name for this substance
language	Σ	0..*	CodeableConcept	Human language that the name is written in Binding: CommonLanguages (preferred): IETF language tag Additional Bindings Purpose AllLanguages Max Binding
domain	Σ	0..*	CodeableConcept	The use context of this name e.g. as an active ingredient or as a food colour additive Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.
jurisdiction	Σ	0..*	CodeableConcept	The jurisdiction where this name applies Binding: Jurisdiction ValueSet (example): Jurisdiction codes
synonym	Σ	0..*	See name (SubstanceDefinition)	A synonym of this particular name, by which the substance is also known
translation	Σ	0..*	See name (SubstanceDefinition)	A translation for this name into another human language
official	Σ	0..*	BackboneElement	Details of the official nature of this name
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Constraints: ext-1
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized Constraints: ext-1
authority	Σ	0..1	CodeableConcept	Which authority uses this official name Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.
status	Σ	0..1	CodeableConcept	The status of the official name, for example 'draft', 'active' Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
date	Σ	0..1	dateTime	Date of official name change
source	Σ	0..*	Reference(DocumentReference)	Supporting literature
id		0..1	id	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url Constraints: ext-1
extension:source		0..1	Reference(Resource)	R5: source additional types URL: http://hl7.org/fhir/StructureDefinition/alternate-reference Constraints: ext-1
reference	ΣC	0..1	string	Literal reference, Relative, internal or absolute URL
type	Σ	0..1	uri	Type the reference refers to (e.g. "Patient") Binding: ResourceType (extensible)
identifier	Σ	0..1	Identifier	Logical reference, when literal reference is not known
display	Σ	0..1	string	Text alternative for the resource
relationship	Σ	0..*	BackboneElement	A link between this substance and another
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Constraints: ext-1
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized Constraints: ext-1
substanceDefinition[x]	Σ	0..1		A pointer to another substance, as a resource or a representational code
substanceDefinitionReference			Reference(SubstanceDefinition)
substanceDefinitionCodeableConcept			CodeableConcept
type	Σ	1..1	CodeableConcept	For example "salt to parent", "active moiety" Binding: SubstanceRelationshipType (example): The relationship between two substance types.
isDefining	Σ	0..1	boolean	For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships
amount[x]	Σ	0..1		A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other
amountQuantity			Quantity
amountRatio			Ratio
amountString			string
ratioHighLimitAmount	Σ	0..1	Ratio	For use when the numeric has an uncertain range
comparator	Σ	0..1	CodeableConcept	An operator for the amount, for example "average", "approximately", "less than" Binding: SubstanceAmountType (example): The relationship between two substance types.
source	Σ	0..*	Reference(DocumentReference)	Supporting literature
id		0..1	id	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url Constraints: ext-1
extension:source		0..1	Reference(Resource)	R5: source additional types URL: http://hl7.org/fhir/StructureDefinition/alternate-reference Constraints: ext-1
reference	ΣC	0..1	string	Literal reference, Relative, internal or absolute URL
type	Σ	0..1	uri	Type the reference refers to (e.g. "Patient") Binding: ResourceType (extensible)
identifier	Σ	0..1	Identifier	Logical reference, when literal reference is not known
display	Σ	0..1	string	Text alternative for the resource
sourceMaterial	Σ	0..1	BackboneElement	Material or taxonomic/anatomical source
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Constraints: ext-1
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized Constraints: ext-1
type	Σ	0..1	CodeableConcept	Classification of the origin of the raw material. e.g. cat hair is an Animal source type Binding: SourceMaterialType (example): A classification that provides the origin of the substance raw material.
genus	Σ	0..1	CodeableConcept	The genus of an organism e.g. the Latin epithet of the plant/animal scientific name Binding: SourceMaterialGenus (example): The genus of an organism, typically referring to the Latin epithet of the genus element of the plant/animal scientific name.
species	Σ	0..1	CodeableConcept	The species of an organism e.g. the Latin epithet of the species of the plant/animal Binding: SourceMaterialSpecies (example): A species of origin a substance raw material.
part	Σ	0..1	CodeableConcept	An anatomical origin of the source material within an organism Binding: SourceMaterialPart (example): An anatomical origin of the source material within an organism.
countryOfOrigin	Σ	0..*	CodeableConcept	The country or countries where the material is harvested Binding: Country ValueSet (required): Jurisdiction codes
Documentation for this format

Terminology Bindings

Path	Status	Usage	ValueSet	Version	Source
SubstanceDefinition.​language	Base	preferred	Common Languages	📍4.3.0	FHIR Std.
SubstanceDefinition.​identifier.use	Base	required	IdentifierUse	📍4.3.0	FHIR Std.
SubstanceDefinition.​identifier.type	Base	extensible	IdentifierType	📍4.3.0	FHIR Std.
SubstanceDefinition.​status	Base	preferred	PublicationStatus	📍4.3.0	FHIR Std.
SubstanceDefinition.​domain	Base	example	MedicinalProductDomain	📍4.3.0	FHIR Std.
SubstanceDefinition.​grade	Base	example	SubstanceGrade	📍4.3.0	FHIR Std.
SubstanceDefinition.​moiety.stereochemistry	Base	example	Stereochemistry	📍4.3.0	FHIR Std.
SubstanceDefinition.​moiety.opticalActivity	Base	example	OpticalActivity	📍4.3.0	FHIR Std.
SubstanceDefinition.​moiety.measurementType	Base	example	SubstanceAmountType	📍4.3.0	FHIR Std.
SubstanceDefinition.​property.type	Base	example	http://hl7.org/fhir/ValueSet/product-characteristic-codes	Not State	Unknown
SubstanceDefinition.​molecularWeight.method	Base	example	WeightMethod	📍4.3.0	FHIR Std.
SubstanceDefinition.​molecularWeight.type	Base	example	WeightType	📍4.3.0	FHIR Std.
SubstanceDefinition.​structure.stereochemistry	Base	example	Stereochemistry	📍4.3.0	FHIR Std.
SubstanceDefinition.​structure.opticalActivity	Base	example	OpticalActivity	📍4.3.0	FHIR Std.
SubstanceDefinition.​structure.technique	Base	example	StructureTechnique	📍4.3.0	FHIR Std.
SubstanceDefinition.​structure.sourceDocument.​type	Base	extensible	ResourceType	📍4.3.0	FHIR Std.
SubstanceDefinition.​structure.representation.​type	Base	example	SubstanceRepresentationType	📍4.3.0	FHIR Std.
SubstanceDefinition.​structure.representation.​format	Base	example	SubstanceRepresentationFormat	📍4.3.0	FHIR Std.
SubstanceDefinition.​structure.representation.​document.type	Base	extensible	ResourceType	📍4.3.0	FHIR Std.
SubstanceDefinition.​code.status	Base	preferred	PublicationStatus	📍4.3.0	FHIR Std.
SubstanceDefinition.​code.source.type	Base	extensible	ResourceType	📍4.3.0	FHIR Std.
SubstanceDefinition.​name.type	Base	example	SubstanceNameType	📍4.3.0	FHIR Std.
SubstanceDefinition.​name.status	Base	preferred	PublicationStatus	📍4.3.0	FHIR Std.
SubstanceDefinition.​name.language	Base	preferred	Common Languages	📍4.3.0	FHIR Std.
SubstanceDefinition.​name.domain	Base	example	SubstanceNameDomain	📍4.3.0	FHIR Std.
SubstanceDefinition.​name.jurisdiction	Base	example	Jurisdiction	📍4.3.0	FHIR Std.
SubstanceDefinition.​name.official.authority	Base	preferred	SubstanceNameAuthority	📍4.3.0	FHIR Std.
SubstanceDefinition.​name.official.status	Base	preferred	PublicationStatus	📍4.3.0	FHIR Std.
SubstanceDefinition.​name.source.type	Base	extensible	ResourceType	📍4.3.0	FHIR Std.
SubstanceDefinition.​relationship.type	Base	example	SubstanceRelationshipType	📍4.3.0	FHIR Std.
SubstanceDefinition.​relationship.comparator	Base	example	SubstanceAmountType	📍4.3.0	FHIR Std.
SubstanceDefinition.​relationship.source.​type	Base	extensible	ResourceType	📍4.3.0	FHIR Std.
SubstanceDefinition.​sourceMaterial.type	Base	example	SourceMaterialType	📍4.3.0	FHIR Std.
SubstanceDefinition.​sourceMaterial.genus	Base	example	SourceMaterialGenus	📍4.3.0	FHIR Std.
SubstanceDefinition.​sourceMaterial.species	Base	example	SourceMaterialSpecies	📍4.3.0	FHIR Std.
SubstanceDefinition.​sourceMaterial.part	Base	example	SourceMaterialPart	📍4.3.0	FHIR Std.
SubstanceDefinition.​sourceMaterial.countryOfOrigin	Base	required	Country	📍4.3.0	FHIR Std.

Constraints

Id	Grade	Path(s)	Description	Expression
dom-2	error	SubstanceDefinition	If the resource is contained in another resource, it SHALL NOT contain nested Resources	contained.contained.empty()
dom-3	error	SubstanceDefinition	If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource	contained.where(((id.exists() and ('#'+id in (%resource.descendants().reference | %resource.descendants().as(canonical) | %resource.descendants().as(uri) | %resource.descendants().as(url)))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(uri) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4	error	SubstanceDefinition	If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated	contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5	error	SubstanceDefinition	If a resource is contained in another resource, it SHALL NOT have a security label	contained.meta.security.empty()
dom-6	best practice	SubstanceDefinition	A resource should have narrative for robust management	text.`div`.exists()
dom-r4b	warning	SubstanceDefinition.contained	Containing new R4B resources within R4 resources may cause interoperability issues if instances are shared with R4 systems	($this is Citation or $this is Evidence or $this is EvidenceReport or $this is EvidenceVariable or $this is MedicinalProductDefinition or $this is PackagedProductDefinition or $this is AdministrableProductDefinition or $this is Ingredient or $this is ClinicalUseDefinition or $this is RegulatedAuthorization or $this is SubstanceDefinition or $this is SubscriptionStatus or $this is SubscriptionTopic) implies (%resource is Citation or %resource is Evidence or %resource is EvidenceReport or %resource is EvidenceVariable or %resource is MedicinalProductDefinition or %resource is PackagedProductDefinition or %resource is AdministrableProductDefinition or %resource is Ingredient or %resource is ClinicalUseDefinition or %resource is RegulatedAuthorization or %resource is SubstanceDefinition or %resource is SubscriptionStatus or %resource is SubscriptionTopic)
ele-1	error	SubstanceDefinition.meta, SubstanceDefinition.implicitRules, SubstanceDefinition.language, SubstanceDefinition.text, SubstanceDefinition.extension, SubstanceDefinition.extension:characterization, SubstanceDefinition.extension:referenceInformation, SubstanceDefinition.extension:nucleicAcid, SubstanceDefinition.extension:polymer, SubstanceDefinition.extension:protein, SubstanceDefinition.modifierExtension, SubstanceDefinition.identifier, SubstanceDefinition.identifier.extension, SubstanceDefinition.identifier.extension:identifier, SubstanceDefinition.identifier.use, SubstanceDefinition.identifier.type, SubstanceDefinition.identifier.system, SubstanceDefinition.identifier.value, SubstanceDefinition.identifier.period, SubstanceDefinition.identifier.assigner, SubstanceDefinition.version, SubstanceDefinition.version.extension, SubstanceDefinition.version.extension:version, SubstanceDefinition.status, SubstanceDefinition.status.extension, SubstanceDefinition.status.extension:status, SubstanceDefinition.status.coding, SubstanceDefinition.status.text, SubstanceDefinition.classification, SubstanceDefinition.domain, SubstanceDefinition.grade, SubstanceDefinition.description, SubstanceDefinition.description.extension, SubstanceDefinition.description.extension:description, SubstanceDefinition.informationSource, SubstanceDefinition.note, SubstanceDefinition.manufacturer, SubstanceDefinition.supplier, SubstanceDefinition.moiety, SubstanceDefinition.moiety.extension, SubstanceDefinition.moiety.modifierExtension, SubstanceDefinition.moiety.role, SubstanceDefinition.moiety.identifier, SubstanceDefinition.moiety.name, SubstanceDefinition.moiety.stereochemistry, SubstanceDefinition.moiety.opticalActivity, SubstanceDefinition.moiety.molecularFormula, SubstanceDefinition.moiety.amount[x], SubstanceDefinition.moiety.measurementType, SubstanceDefinition.property, SubstanceDefinition.property.extension, SubstanceDefinition.property.modifierExtension, SubstanceDefinition.property.type, SubstanceDefinition.property.value[x], SubstanceDefinition.molecularWeight, SubstanceDefinition.molecularWeight.extension, SubstanceDefinition.molecularWeight.modifierExtension, SubstanceDefinition.molecularWeight.method, SubstanceDefinition.molecularWeight.type, SubstanceDefinition.molecularWeight.amount, SubstanceDefinition.structure, SubstanceDefinition.structure.extension, SubstanceDefinition.structure.modifierExtension, SubstanceDefinition.structure.stereochemistry, SubstanceDefinition.structure.opticalActivity, SubstanceDefinition.structure.molecularFormula, SubstanceDefinition.structure.molecularFormulaByMoiety, SubstanceDefinition.structure.molecularWeight, SubstanceDefinition.structure.technique, SubstanceDefinition.structure.sourceDocument, SubstanceDefinition.structure.sourceDocument.extension, SubstanceDefinition.structure.sourceDocument.extension:sourceDocument, SubstanceDefinition.structure.sourceDocument.reference, SubstanceDefinition.structure.sourceDocument.type, SubstanceDefinition.structure.sourceDocument.identifier, SubstanceDefinition.structure.sourceDocument.display, SubstanceDefinition.structure.representation, SubstanceDefinition.structure.representation.extension, SubstanceDefinition.structure.representation.modifierExtension, SubstanceDefinition.structure.representation.type, SubstanceDefinition.structure.representation.representation, SubstanceDefinition.structure.representation.format, SubstanceDefinition.structure.representation.document, SubstanceDefinition.structure.representation.document.extension, SubstanceDefinition.structure.representation.document.extension:document, SubstanceDefinition.structure.representation.document.reference, SubstanceDefinition.structure.representation.document.type, SubstanceDefinition.structure.representation.document.identifier, SubstanceDefinition.structure.representation.document.display, SubstanceDefinition.code, SubstanceDefinition.code.extension, SubstanceDefinition.code.modifierExtension, SubstanceDefinition.code.code, SubstanceDefinition.code.status, SubstanceDefinition.code.statusDate, SubstanceDefinition.code.note, SubstanceDefinition.code.source, SubstanceDefinition.code.source.extension, SubstanceDefinition.code.source.extension:source, SubstanceDefinition.code.source.reference, SubstanceDefinition.code.source.type, SubstanceDefinition.code.source.identifier, SubstanceDefinition.code.source.display, SubstanceDefinition.name, SubstanceDefinition.name.extension, SubstanceDefinition.name.extension:name, SubstanceDefinition.name.modifierExtension, SubstanceDefinition.name.name, SubstanceDefinition.name.type, SubstanceDefinition.name.status, SubstanceDefinition.name.preferred, SubstanceDefinition.name.language, SubstanceDefinition.name.domain, SubstanceDefinition.name.jurisdiction, SubstanceDefinition.name.synonym, SubstanceDefinition.name.translation, SubstanceDefinition.name.official, SubstanceDefinition.name.official.extension, SubstanceDefinition.name.official.modifierExtension, SubstanceDefinition.name.official.authority, SubstanceDefinition.name.official.status, SubstanceDefinition.name.official.date, SubstanceDefinition.name.source, SubstanceDefinition.name.source.extension, SubstanceDefinition.name.source.extension:source, SubstanceDefinition.name.source.reference, SubstanceDefinition.name.source.type, SubstanceDefinition.name.source.identifier, SubstanceDefinition.name.source.display, SubstanceDefinition.relationship, SubstanceDefinition.relationship.extension, SubstanceDefinition.relationship.modifierExtension, SubstanceDefinition.relationship.substanceDefinition[x], SubstanceDefinition.relationship.type, SubstanceDefinition.relationship.isDefining, SubstanceDefinition.relationship.amount[x], SubstanceDefinition.relationship.ratioHighLimitAmount, SubstanceDefinition.relationship.comparator, SubstanceDefinition.relationship.source, SubstanceDefinition.relationship.source.extension, SubstanceDefinition.relationship.source.extension:source, SubstanceDefinition.relationship.source.reference, SubstanceDefinition.relationship.source.type, SubstanceDefinition.relationship.source.identifier, SubstanceDefinition.relationship.source.display, SubstanceDefinition.sourceMaterial, SubstanceDefinition.sourceMaterial.extension, SubstanceDefinition.sourceMaterial.modifierExtension, SubstanceDefinition.sourceMaterial.type, SubstanceDefinition.sourceMaterial.genus, SubstanceDefinition.sourceMaterial.species, SubstanceDefinition.sourceMaterial.part, SubstanceDefinition.sourceMaterial.countryOfOrigin	All FHIR elements must have a @value or children	hasValue() or (children().count() > id.count())
ext-1	error	SubstanceDefinition.extension, SubstanceDefinition.extension:characterization, SubstanceDefinition.extension:referenceInformation, SubstanceDefinition.extension:nucleicAcid, SubstanceDefinition.extension:polymer, SubstanceDefinition.extension:protein, SubstanceDefinition.modifierExtension, SubstanceDefinition.identifier.extension, SubstanceDefinition.identifier.extension:identifier, SubstanceDefinition.version.extension, SubstanceDefinition.version.extension:version, SubstanceDefinition.status.extension, SubstanceDefinition.status.extension:status, SubstanceDefinition.description.extension, SubstanceDefinition.description.extension:description, SubstanceDefinition.moiety.extension, SubstanceDefinition.moiety.modifierExtension, SubstanceDefinition.property.extension, SubstanceDefinition.property.modifierExtension, SubstanceDefinition.molecularWeight.extension, SubstanceDefinition.molecularWeight.modifierExtension, SubstanceDefinition.structure.extension, SubstanceDefinition.structure.modifierExtension, SubstanceDefinition.structure.sourceDocument.extension, SubstanceDefinition.structure.sourceDocument.extension:sourceDocument, SubstanceDefinition.structure.representation.extension, SubstanceDefinition.structure.representation.modifierExtension, SubstanceDefinition.structure.representation.document.extension, SubstanceDefinition.structure.representation.document.extension:document, SubstanceDefinition.code.extension, SubstanceDefinition.code.modifierExtension, SubstanceDefinition.code.source.extension, SubstanceDefinition.code.source.extension:source, SubstanceDefinition.name.extension, SubstanceDefinition.name.extension:name, SubstanceDefinition.name.modifierExtension, SubstanceDefinition.name.official.extension, SubstanceDefinition.name.official.modifierExtension, SubstanceDefinition.name.source.extension, SubstanceDefinition.name.source.extension:source, SubstanceDefinition.relationship.extension, SubstanceDefinition.relationship.modifierExtension, SubstanceDefinition.relationship.source.extension, SubstanceDefinition.relationship.source.extension:source, SubstanceDefinition.sourceMaterial.extension, SubstanceDefinition.sourceMaterial.modifierExtension	Must have either extensions or value[x], not both	extension.exists() != value.exists()

This structure is derived from SubstanceDefinition

Summary

Extensions

This structure refers to these extensions:

• http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.characterization|0.1.0
• http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.referenceInformation|0.1.0
• http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.nucleicAcid|0.1.0
• http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.polymer|0.1.0
• http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.protein|0.1.0
• http://hl7.org/fhir/StructureDefinition/artifact-identifier|5.2.0
• http://hl7.org/fhir/StructureDefinition/artifact-version|5.2.0
• http://hl7.org/fhir/StructureDefinition/artifact-status|5.2.0
• http://hl7.org/fhir/StructureDefinition/artifact-description|5.2.0
• http://hl7.org/fhir/StructureDefinition/alternate-reference|5.2.0
• http://hl7.org/fhir/StructureDefinition/artifact-name|5.2.0

Maturity: 0

Key Elements View

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
SubstanceDefinition		0..*	SubstanceDefinition(4.3.0)	The detailed description of a substance, typically at a level beyond what is used for prescribing
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url Constraints: ext-1
extension:characterization		0..*	(Complex)	R5: General specifications for this substance (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.characterization Constraints: ext-1
extension:referenceInformation		0..1	Reference(Cross-version Profile for R5.SubstanceReferenceInformation for use in FHIR R4B(0.1.0) | Basic)	R5: General information detailing this substance (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.referenceInformation Constraints: ext-1
extension:nucleicAcid		0..1	Reference(Cross-version Profile for R5.SubstanceNucleicAcid for use in FHIR R4B(0.1.0) | Basic)	R5: Data items specific to nucleic acids (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.nucleicAcid Constraints: ext-1
extension:polymer		0..1	Reference(Cross-version Profile for R5.SubstancePolymer for use in FHIR R4B(0.1.0) | Basic)	R5: Data items specific to polymers (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.polymer Constraints: ext-1
extension:protein		0..1	Reference(Cross-version Profile for R5.SubstanceProtein for use in FHIR R4B(0.1.0) | Basic)	R5: Data items specific to proteins (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.protein Constraints: ext-1
modifierExtension	?!	0..*	Extension	Extensions that cannot be ignored Constraints: ext-1
Documentation for this format

Constraints

Id	Grade	Path(s)	Description	Expression
dom-2	error	SubstanceDefinition	If the resource is contained in another resource, it SHALL NOT contain nested Resources	contained.contained.empty()
dom-3	error	SubstanceDefinition	If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource	contained.where(((id.exists() and ('#'+id in (%resource.descendants().reference | %resource.descendants().as(canonical) | %resource.descendants().as(uri) | %resource.descendants().as(url)))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(uri) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4	error	SubstanceDefinition	If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated	contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5	error	SubstanceDefinition	If a resource is contained in another resource, it SHALL NOT have a security label	contained.meta.security.empty()
dom-6	best practice	SubstanceDefinition	A resource should have narrative for robust management	text.`div`.exists()
ele-1	error	SubstanceDefinition.implicitRules, SubstanceDefinition.extension, SubstanceDefinition.extension:characterization, SubstanceDefinition.extension:referenceInformation, SubstanceDefinition.extension:nucleicAcid, SubstanceDefinition.extension:polymer, SubstanceDefinition.extension:protein, SubstanceDefinition.modifierExtension	All FHIR elements must have a @value or children	hasValue() or (children().count() > id.count())
ext-1	error	SubstanceDefinition.extension, SubstanceDefinition.extension:characterization, SubstanceDefinition.extension:referenceInformation, SubstanceDefinition.extension:nucleicAcid, SubstanceDefinition.extension:polymer, SubstanceDefinition.extension:protein, SubstanceDefinition.modifierExtension	Must have either extensions or value[x], not both	extension.exists() != value.exists()

Differential View

This structure is derived from SubstanceDefinition

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
SubstanceDefinition		0..*	SubstanceDefinition(4.3.0)	The detailed description of a substance, typically at a level beyond what is used for prescribing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:characterization		0..*	(Complex)	R5: General specifications for this substance (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.characterization
extension:referenceInformation		0..1	Reference(Cross-version Profile for R5.SubstanceReferenceInformation for use in FHIR R4B(0.1.0) | Basic)	R5: General information detailing this substance (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.referenceInformation
extension:nucleicAcid		0..1	Reference(Cross-version Profile for R5.SubstanceNucleicAcid for use in FHIR R4B(0.1.0) | Basic)	R5: Data items specific to nucleic acids (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.nucleicAcid
extension:polymer		0..1	Reference(Cross-version Profile for R5.SubstancePolymer for use in FHIR R4B(0.1.0) | Basic)	R5: Data items specific to polymers (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.polymer
extension:protein		0..1	Reference(Cross-version Profile for R5.SubstanceProtein for use in FHIR R4B(0.1.0) | Basic)	R5: Data items specific to proteins (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.protein
identifier
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:identifier		0..*	Identifier	R5: identifier URL: http://hl7.org/fhir/StructureDefinition/artifact-identifier
version
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:version		0..1	string	R5: version URL: http://hl7.org/fhir/StructureDefinition/artifact-version
status
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:status		0..1	code	R5: status URL: http://hl7.org/fhir/StructureDefinition/artifact-status Binding: PublicationStatus (required): The lifecycle status of an artifact.
description
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:description		0..1	markdown	R5: description URL: http://hl7.org/fhir/StructureDefinition/artifact-description
structure
sourceDocument
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:sourceDocument		0..*	Reference(Resource)	R5: sourceDocument additional types URL: http://hl7.org/fhir/StructureDefinition/alternate-reference
representation
document
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:document		0..1	Reference(Resource)	R5: document additional types URL: http://hl7.org/fhir/StructureDefinition/alternate-reference
code
source
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:source		0..*	Reference(Resource)	R5: source additional types URL: http://hl7.org/fhir/StructureDefinition/alternate-reference
name
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:name		0..*	string	R5: name URL: http://hl7.org/fhir/StructureDefinition/artifact-name
source
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:source		0..*	Reference(Resource)	R5: source additional types URL: http://hl7.org/fhir/StructureDefinition/alternate-reference
relationship
source
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url
extension:source		0..*	Reference(Resource)	R5: source additional types URL: http://hl7.org/fhir/StructureDefinition/alternate-reference
Documentation for this format

Snapshot View

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
SubstanceDefinition		0..*	SubstanceDefinition(4.3.0)	The detailed description of a substance, typically at a level beyond what is used for prescribing
id	Σ	0..1	id	Logical id of this artifact
meta	Σ	0..1	Meta	Metadata about the resource
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
language		0..1	code	Language of the resource content Binding: CommonLanguages (preferred): IETF language tag Additional Bindings Purpose AllLanguages Max Binding
text		0..1	Narrative	Text summary of the resource, for human interpretation This profile does not constrain the narrative in regard to content, language, or traceability to data elements
contained		0..*	Resource	Contained, inline Resources Constraints: dom-r4b
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url Constraints: ext-1
extension:characterization		0..*	(Complex)	R5: General specifications for this substance (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.characterization Constraints: ext-1
extension:referenceInformation		0..1	Reference(Cross-version Profile for R5.SubstanceReferenceInformation for use in FHIR R4B(0.1.0) | Basic)	R5: General information detailing this substance (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.referenceInformation Constraints: ext-1
extension:nucleicAcid		0..1	Reference(Cross-version Profile for R5.SubstanceNucleicAcid for use in FHIR R4B(0.1.0) | Basic)	R5: Data items specific to nucleic acids (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.nucleicAcid Constraints: ext-1
extension:polymer		0..1	Reference(Cross-version Profile for R5.SubstancePolymer for use in FHIR R4B(0.1.0) | Basic)	R5: Data items specific to polymers (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.polymer Constraints: ext-1
extension:protein		0..1	Reference(Cross-version Profile for R5.SubstanceProtein for use in FHIR R4B(0.1.0) | Basic)	R5: Data items specific to proteins (new) URL: http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.protein Constraints: ext-1
modifierExtension	?!	0..*	Extension	Extensions that cannot be ignored Constraints: ext-1
identifier	Σ	0..*	Identifier	Identifier by which this substance is known
id		0..1	id	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url Constraints: ext-1
extension:identifier		0..*	Identifier	R5: identifier URL: http://hl7.org/fhir/StructureDefinition/artifact-identifier Constraints: ext-1
use	?!Σ	0..1	code	usual | official | temp | secondary | old (If known) Binding: IdentifierUse (required)
type	Σ	0..1	CodeableConcept	Description of identifier Binding: Identifier Type Codes (extensible)
system	Σ	0..1	uri	The namespace for the identifier value Example General: http://www.acme.com/identifiers/patient
value	Σ	0..1	string	The value that is unique Example General: 123456
period	Σ	0..1	Period	Time period when id is/was valid for use
assigner	Σ	0..1	Reference(Organization)	Organization that issued id (may be just text)
version	Σ	0..1	string	A business level version identifier of the substance
id		0..1	string	xml:id (or equivalent in JSON)
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url Constraints: ext-1
extension:version		0..1	string	R5: version URL: http://hl7.org/fhir/StructureDefinition/artifact-version Constraints: ext-1
value		0..1	string	Primitive value for string Max Length:1048576
status	Σ	0..1	CodeableConcept	Status of substance within the catalogue e.g. active, retired Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
id		0..1	id	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url Constraints: ext-1
extension:status		0..1	code	R5: status URL: http://hl7.org/fhir/StructureDefinition/artifact-status Binding: PublicationStatus (required): The lifecycle status of an artifact. Constraints: ext-1
coding	Σ	0..*	Coding	Code defined by a terminology system
text	Σ	0..1	string	Plain text representation of the concept
classification	Σ	0..*	CodeableConcept	A categorization, high level e.g. polymer or nucleic acid, or food, chemical, biological, or lower e.g. polymer linear or branch chain, or type of impurity
domain	Σ	0..1	CodeableConcept	If the substance applies to human or veterinary use Binding: MedicinalProductDomain (example): Applicable domain for this product (e.g. human, veterinary).
grade	Σ	0..*	CodeableConcept	The quality standard, established benchmark, to which substance complies (e.g. USP/NF, BP) Binding: SubstanceGrade (example): The quality standard, established benchmark, to which a substance complies
description	Σ	0..1	markdown	Textual description of the substance
id		0..1	string	xml:id (or equivalent in JSON)
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url Constraints: ext-1
extension:description		0..1	markdown	R5: description URL: http://hl7.org/fhir/StructureDefinition/artifact-description Constraints: ext-1
value		0..1	markdown	Primitive value for markdown
informationSource	Σ	0..*	Reference(Citation)	Supporting literature
note	Σ	0..*	Annotation	Textual comment about the substance's catalogue or registry record
manufacturer	Σ	0..*	Reference(Organization)	The entity that creates, makes, produces or fabricates the substance
supplier	Σ	0..*	Reference(Organization)	An entity that is the source for the substance. It may be different from the manufacturer
moiety	Σ	0..*	BackboneElement	Moiety, for structural modifications
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Constraints: ext-1
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized Constraints: ext-1
role	Σ	0..1	CodeableConcept	Role that the moiety is playing
identifier	Σ	0..1	Identifier	Identifier by which this moiety substance is known
name	Σ	0..1	string	Textual name for this moiety substance
stereochemistry	Σ	0..1	CodeableConcept	Stereochemistry type Binding: Stereochemistry (example): The optical rotation type of a substance.
opticalActivity	Σ	0..1	CodeableConcept	Optical activity type Binding: OpticalActivity (example): The optical rotation type of a substance.
molecularFormula	Σ	0..1	string	Molecular formula for this moiety (e.g. with the Hill system)
amount[x]	Σ	0..1		Quantitative value for this moiety
amountQuantity			Quantity
amountString			string
measurementType	Σ	0..1	CodeableConcept	The measurement type of the quantitative value Binding: SubstanceAmountType (example): The relationship between two substance types.
property	Σ	0..*	BackboneElement	General specifications for this substance
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Constraints: ext-1
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized Constraints: ext-1
type	Σ	1..1	CodeableConcept	A code expressing the type of property Binding: product-characteristic-codes (??) (example): This value set includes all observable entity codes from SNOMED CT - provided as an exemplar value set.
value[x]	Σ	0..1		A value for the property
valueCodeableConcept			CodeableConcept
valueQuantity			Quantity
valueDate			date
valueBoolean			boolean
valueAttachment			Attachment
molecularWeight	Σ	0..*	BackboneElement	The molecular weight or weight range
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Constraints: ext-1
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized Constraints: ext-1
method	Σ	0..1	CodeableConcept	The method by which the weight was determined Binding: WeightMethod (example): The method by which the substance weight was measured.
type	Σ	0..1	CodeableConcept	Type of molecular weight e.g. exact, average, weight average Binding: WeightType (example): The type of substance weight measurement.
amount	Σ	1..1	Quantity	Used to capture quantitative values for a variety of elements
structure	Σ	0..1	BackboneElement	Structural information
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Constraints: ext-1
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized Constraints: ext-1
stereochemistry	Σ	0..1	CodeableConcept	Stereochemistry type Binding: Stereochemistry (example): The optical rotation type of a substance.
opticalActivity	Σ	0..1	CodeableConcept	Optical activity type Binding: OpticalActivity (example): The optical rotation type of a substance.
molecularFormula	Σ	0..1	string	Molecular formula (e.g. using the Hill system)
molecularFormulaByMoiety	Σ	0..1	string	Specified per moiety according to the Hill system
molecularWeight	Σ	0..1	See molecularWeight (SubstanceDefinition)	The molecular weight or weight range
technique	Σ	0..*	CodeableConcept	The method used to find the structure e.g. X-ray, NMR Binding: StructureTechnique (example): The method used to elucidate the structure or characterization of the drug substance.
sourceDocument	Σ	0..*	Reference(DocumentReference)	Source of information for the structure
id		0..1	id	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url Constraints: ext-1
extension:sourceDocument		0..1	Reference(Resource)	R5: sourceDocument additional types URL: http://hl7.org/fhir/StructureDefinition/alternate-reference Constraints: ext-1
reference	ΣC	0..1	string	Literal reference, Relative, internal or absolute URL
type	Σ	0..1	uri	Type the reference refers to (e.g. "Patient") Binding: ResourceType (extensible)
identifier	Σ	0..1	Identifier	Logical reference, when literal reference is not known
display	Σ	0..1	string	Text alternative for the resource
representation	Σ	0..*	BackboneElement	A depiction of the structure or characterization of the substance
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Constraints: ext-1
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized Constraints: ext-1
type	Σ	0..1	CodeableConcept	The kind of structural representation (e.g. full, partial) Binding: SubstanceRepresentationType (example): A format of a substance representation.
representation	Σ	0..1	string	The structural representation or characterization as a text string in a standard format
format	Σ	0..1	CodeableConcept	The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format) Binding: SubstanceRepresentationFormat (example): A format of a substance representation.
document	Σ	0..1	Reference(DocumentReference)	An attachment with the structural representation e.g. a structure graphic or AnIML file
id		0..1	id	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url Constraints: ext-1
extension:document		0..1	Reference(Resource)	R5: document additional types URL: http://hl7.org/fhir/StructureDefinition/alternate-reference Constraints: ext-1
reference	ΣC	0..1	string	Literal reference, Relative, internal or absolute URL
type	Σ	0..1	uri	Type the reference refers to (e.g. "Patient") Binding: ResourceType (extensible)
identifier	Σ	0..1	Identifier	Logical reference, when literal reference is not known
display	Σ	0..1	string	Text alternative for the resource
code	Σ	0..*	BackboneElement	Codes associated with the substance
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Constraints: ext-1
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized Constraints: ext-1
code	Σ	0..1	CodeableConcept	The specific code
status	Σ	0..1	CodeableConcept	Status of the code assignment, for example 'provisional', 'approved' Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
statusDate	Σ	0..1	dateTime	The date at which the code status was changed
note	Σ	0..*	Annotation	Any comment can be provided in this field
source	Σ	0..*	Reference(DocumentReference)	Supporting literature
id		0..1	id	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url Constraints: ext-1
extension:source		0..1	Reference(Resource)	R5: source additional types URL: http://hl7.org/fhir/StructureDefinition/alternate-reference Constraints: ext-1
reference	ΣC	0..1	string	Literal reference, Relative, internal or absolute URL
type	Σ	0..1	uri	Type the reference refers to (e.g. "Patient") Binding: ResourceType (extensible)
identifier	Σ	0..1	Identifier	Logical reference, when literal reference is not known
display	Σ	0..1	string	Text alternative for the resource
name	Σ	0..*	BackboneElement	Names applicable to this substance
id		0..1	string	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url Constraints: ext-1
extension:name		0..*	string	R5: name URL: http://hl7.org/fhir/StructureDefinition/artifact-name Constraints: ext-1
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized Constraints: ext-1
name	Σ	1..1	string	The actual name
type	Σ	0..1	CodeableConcept	Name type e.g. 'systematic', 'scientific, 'brand' Binding: SubstanceNameType (example): The type of a name given to a substance.
status	Σ	0..1	CodeableConcept	The status of the name e.g. 'current', 'proposed' Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
preferred	Σ	0..1	boolean	If this is the preferred name for this substance
language	Σ	0..*	CodeableConcept	Human language that the name is written in Binding: CommonLanguages (preferred): IETF language tag Additional Bindings Purpose AllLanguages Max Binding
domain	Σ	0..*	CodeableConcept	The use context of this name e.g. as an active ingredient or as a food colour additive Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.
jurisdiction	Σ	0..*	CodeableConcept	The jurisdiction where this name applies Binding: Jurisdiction ValueSet (example): Jurisdiction codes
synonym	Σ	0..*	See name (SubstanceDefinition)	A synonym of this particular name, by which the substance is also known
translation	Σ	0..*	See name (SubstanceDefinition)	A translation for this name into another human language
official	Σ	0..*	BackboneElement	Details of the official nature of this name
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Constraints: ext-1
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized Constraints: ext-1
authority	Σ	0..1	CodeableConcept	Which authority uses this official name Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.
status	Σ	0..1	CodeableConcept	The status of the official name, for example 'draft', 'active' Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
date	Σ	0..1	dateTime	Date of official name change
source	Σ	0..*	Reference(DocumentReference)	Supporting literature
id		0..1	id	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url Constraints: ext-1
extension:source		0..1	Reference(Resource)	R5: source additional types URL: http://hl7.org/fhir/StructureDefinition/alternate-reference Constraints: ext-1
reference	ΣC	0..1	string	Literal reference, Relative, internal or absolute URL
type	Σ	0..1	uri	Type the reference refers to (e.g. "Patient") Binding: ResourceType (extensible)
identifier	Σ	0..1	Identifier	Logical reference, when literal reference is not known
display	Σ	0..1	string	Text alternative for the resource
relationship	Σ	0..*	BackboneElement	A link between this substance and another
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Constraints: ext-1
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized Constraints: ext-1
substanceDefinition[x]	Σ	0..1		A pointer to another substance, as a resource or a representational code
substanceDefinitionReference			Reference(SubstanceDefinition)
substanceDefinitionCodeableConcept			CodeableConcept
type	Σ	1..1	CodeableConcept	For example "salt to parent", "active moiety" Binding: SubstanceRelationshipType (example): The relationship between two substance types.
isDefining	Σ	0..1	boolean	For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships
amount[x]	Σ	0..1		A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other
amountQuantity			Quantity
amountRatio			Ratio
amountString			string
ratioHighLimitAmount	Σ	0..1	Ratio	For use when the numeric has an uncertain range
comparator	Σ	0..1	CodeableConcept	An operator for the amount, for example "average", "approximately", "less than" Binding: SubstanceAmountType (example): The relationship between two substance types.
source	Σ	0..*	Reference(DocumentReference)	Supporting literature
id		0..1	id	Unique id for inter-element referencing
Slices for extension		0..*	Extension	Extension Slice: Unordered, Open by value:url Constraints: ext-1
extension:source		0..1	Reference(Resource)	R5: source additional types URL: http://hl7.org/fhir/StructureDefinition/alternate-reference Constraints: ext-1
reference	ΣC	0..1	string	Literal reference, Relative, internal or absolute URL
type	Σ	0..1	uri	Type the reference refers to (e.g. "Patient") Binding: ResourceType (extensible)
identifier	Σ	0..1	Identifier	Logical reference, when literal reference is not known
display	Σ	0..1	string	Text alternative for the resource
sourceMaterial	Σ	0..1	BackboneElement	Material or taxonomic/anatomical source
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Constraints: ext-1
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized Constraints: ext-1
type	Σ	0..1	CodeableConcept	Classification of the origin of the raw material. e.g. cat hair is an Animal source type Binding: SourceMaterialType (example): A classification that provides the origin of the substance raw material.
genus	Σ	0..1	CodeableConcept	The genus of an organism e.g. the Latin epithet of the plant/animal scientific name Binding: SourceMaterialGenus (example): The genus of an organism, typically referring to the Latin epithet of the genus element of the plant/animal scientific name.
species	Σ	0..1	CodeableConcept	The species of an organism e.g. the Latin epithet of the species of the plant/animal Binding: SourceMaterialSpecies (example): A species of origin a substance raw material.
part	Σ	0..1	CodeableConcept	An anatomical origin of the source material within an organism Binding: SourceMaterialPart (example): An anatomical origin of the source material within an organism.
countryOfOrigin	Σ	0..*	CodeableConcept	The country or countries where the material is harvested Binding: Country ValueSet (required): Jurisdiction codes
Documentation for this format

Terminology Bindings

Path	Status	Usage	ValueSet	Version	Source
SubstanceDefinition.​language	Base	preferred	Common Languages	📍4.3.0	FHIR Std.
SubstanceDefinition.​identifier.use	Base	required	IdentifierUse	📍4.3.0	FHIR Std.
SubstanceDefinition.​identifier.type	Base	extensible	IdentifierType	📍4.3.0	FHIR Std.
SubstanceDefinition.​status	Base	preferred	PublicationStatus	📍4.3.0	FHIR Std.
SubstanceDefinition.​domain	Base	example	MedicinalProductDomain	📍4.3.0	FHIR Std.
SubstanceDefinition.​grade	Base	example	SubstanceGrade	📍4.3.0	FHIR Std.
SubstanceDefinition.​moiety.stereochemistry	Base	example	Stereochemistry	📍4.3.0	FHIR Std.
SubstanceDefinition.​moiety.opticalActivity	Base	example	OpticalActivity	📍4.3.0	FHIR Std.
SubstanceDefinition.​moiety.measurementType	Base	example	SubstanceAmountType	📍4.3.0	FHIR Std.
SubstanceDefinition.​property.type	Base	example	http://hl7.org/fhir/ValueSet/product-characteristic-codes	Not State	Unknown
SubstanceDefinition.​molecularWeight.method	Base	example	WeightMethod	📍4.3.0	FHIR Std.
SubstanceDefinition.​molecularWeight.type	Base	example	WeightType	📍4.3.0	FHIR Std.
SubstanceDefinition.​structure.stereochemistry	Base	example	Stereochemistry	📍4.3.0	FHIR Std.
SubstanceDefinition.​structure.opticalActivity	Base	example	OpticalActivity	📍4.3.0	FHIR Std.
SubstanceDefinition.​structure.technique	Base	example	StructureTechnique	📍4.3.0	FHIR Std.
SubstanceDefinition.​structure.sourceDocument.​type	Base	extensible	ResourceType	📍4.3.0	FHIR Std.
SubstanceDefinition.​structure.representation.​type	Base	example	SubstanceRepresentationType	📍4.3.0	FHIR Std.
SubstanceDefinition.​structure.representation.​format	Base	example	SubstanceRepresentationFormat	📍4.3.0	FHIR Std.
SubstanceDefinition.​structure.representation.​document.type	Base	extensible	ResourceType	📍4.3.0	FHIR Std.
SubstanceDefinition.​code.status	Base	preferred	PublicationStatus	📍4.3.0	FHIR Std.
SubstanceDefinition.​code.source.type	Base	extensible	ResourceType	📍4.3.0	FHIR Std.
SubstanceDefinition.​name.type	Base	example	SubstanceNameType	📍4.3.0	FHIR Std.
SubstanceDefinition.​name.status	Base	preferred	PublicationStatus	📍4.3.0	FHIR Std.
SubstanceDefinition.​name.language	Base	preferred	Common Languages	📍4.3.0	FHIR Std.
SubstanceDefinition.​name.domain	Base	example	SubstanceNameDomain	📍4.3.0	FHIR Std.
SubstanceDefinition.​name.jurisdiction	Base	example	Jurisdiction	📍4.3.0	FHIR Std.
SubstanceDefinition.​name.official.authority	Base	preferred	SubstanceNameAuthority	📍4.3.0	FHIR Std.
SubstanceDefinition.​name.official.status	Base	preferred	PublicationStatus	📍4.3.0	FHIR Std.
SubstanceDefinition.​name.source.type	Base	extensible	ResourceType	📍4.3.0	FHIR Std.
SubstanceDefinition.​relationship.type	Base	example	SubstanceRelationshipType	📍4.3.0	FHIR Std.
SubstanceDefinition.​relationship.comparator	Base	example	SubstanceAmountType	📍4.3.0	FHIR Std.
SubstanceDefinition.​relationship.source.​type	Base	extensible	ResourceType	📍4.3.0	FHIR Std.
SubstanceDefinition.​sourceMaterial.type	Base	example	SourceMaterialType	📍4.3.0	FHIR Std.
SubstanceDefinition.​sourceMaterial.genus	Base	example	SourceMaterialGenus	📍4.3.0	FHIR Std.
SubstanceDefinition.​sourceMaterial.species	Base	example	SourceMaterialSpecies	📍4.3.0	FHIR Std.
SubstanceDefinition.​sourceMaterial.part	Base	example	SourceMaterialPart	📍4.3.0	FHIR Std.
SubstanceDefinition.​sourceMaterial.countryOfOrigin	Base	required	Country	📍4.3.0	FHIR Std.

Constraints

Id	Grade	Path(s)	Description	Expression
dom-2	error	SubstanceDefinition	If the resource is contained in another resource, it SHALL NOT contain nested Resources	contained.contained.empty()
dom-3	error	SubstanceDefinition	If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource	contained.where(((id.exists() and ('#'+id in (%resource.descendants().reference | %resource.descendants().as(canonical) | %resource.descendants().as(uri) | %resource.descendants().as(url)))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(uri) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4	error	SubstanceDefinition	If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated	contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5	error	SubstanceDefinition	If a resource is contained in another resource, it SHALL NOT have a security label	contained.meta.security.empty()
dom-6	best practice	SubstanceDefinition	A resource should have narrative for robust management	text.`div`.exists()
dom-r4b	warning	SubstanceDefinition.contained	Containing new R4B resources within R4 resources may cause interoperability issues if instances are shared with R4 systems	($this is Citation or $this is Evidence or $this is EvidenceReport or $this is EvidenceVariable or $this is MedicinalProductDefinition or $this is PackagedProductDefinition or $this is AdministrableProductDefinition or $this is Ingredient or $this is ClinicalUseDefinition or $this is RegulatedAuthorization or $this is SubstanceDefinition or $this is SubscriptionStatus or $this is SubscriptionTopic) implies (%resource is Citation or %resource is Evidence or %resource is EvidenceReport or %resource is EvidenceVariable or %resource is MedicinalProductDefinition or %resource is PackagedProductDefinition or %resource is AdministrableProductDefinition or %resource is Ingredient or %resource is ClinicalUseDefinition or %resource is RegulatedAuthorization or %resource is SubstanceDefinition or %resource is SubscriptionStatus or %resource is SubscriptionTopic)
ele-1	error	SubstanceDefinition.meta, SubstanceDefinition.implicitRules, SubstanceDefinition.language, SubstanceDefinition.text, SubstanceDefinition.extension, SubstanceDefinition.extension:characterization, SubstanceDefinition.extension:referenceInformation, SubstanceDefinition.extension:nucleicAcid, SubstanceDefinition.extension:polymer, SubstanceDefinition.extension:protein, SubstanceDefinition.modifierExtension, SubstanceDefinition.identifier, SubstanceDefinition.identifier.extension, SubstanceDefinition.identifier.extension:identifier, SubstanceDefinition.identifier.use, SubstanceDefinition.identifier.type, SubstanceDefinition.identifier.system, SubstanceDefinition.identifier.value, SubstanceDefinition.identifier.period, SubstanceDefinition.identifier.assigner, SubstanceDefinition.version, SubstanceDefinition.version.extension, SubstanceDefinition.version.extension:version, SubstanceDefinition.status, SubstanceDefinition.status.extension, SubstanceDefinition.status.extension:status, SubstanceDefinition.status.coding, SubstanceDefinition.status.text, SubstanceDefinition.classification, SubstanceDefinition.domain, SubstanceDefinition.grade, SubstanceDefinition.description, SubstanceDefinition.description.extension, SubstanceDefinition.description.extension:description, SubstanceDefinition.informationSource, SubstanceDefinition.note, SubstanceDefinition.manufacturer, SubstanceDefinition.supplier, SubstanceDefinition.moiety, SubstanceDefinition.moiety.extension, SubstanceDefinition.moiety.modifierExtension, SubstanceDefinition.moiety.role, SubstanceDefinition.moiety.identifier, SubstanceDefinition.moiety.name, SubstanceDefinition.moiety.stereochemistry, SubstanceDefinition.moiety.opticalActivity, SubstanceDefinition.moiety.molecularFormula, SubstanceDefinition.moiety.amount[x], SubstanceDefinition.moiety.measurementType, SubstanceDefinition.property, SubstanceDefinition.property.extension, SubstanceDefinition.property.modifierExtension, SubstanceDefinition.property.type, SubstanceDefinition.property.value[x], SubstanceDefinition.molecularWeight, SubstanceDefinition.molecularWeight.extension, SubstanceDefinition.molecularWeight.modifierExtension, SubstanceDefinition.molecularWeight.method, SubstanceDefinition.molecularWeight.type, SubstanceDefinition.molecularWeight.amount, SubstanceDefinition.structure, SubstanceDefinition.structure.extension, SubstanceDefinition.structure.modifierExtension, SubstanceDefinition.structure.stereochemistry, SubstanceDefinition.structure.opticalActivity, SubstanceDefinition.structure.molecularFormula, SubstanceDefinition.structure.molecularFormulaByMoiety, SubstanceDefinition.structure.molecularWeight, SubstanceDefinition.structure.technique, SubstanceDefinition.structure.sourceDocument, SubstanceDefinition.structure.sourceDocument.extension, SubstanceDefinition.structure.sourceDocument.extension:sourceDocument, SubstanceDefinition.structure.sourceDocument.reference, SubstanceDefinition.structure.sourceDocument.type, SubstanceDefinition.structure.sourceDocument.identifier, SubstanceDefinition.structure.sourceDocument.display, SubstanceDefinition.structure.representation, SubstanceDefinition.structure.representation.extension, SubstanceDefinition.structure.representation.modifierExtension, SubstanceDefinition.structure.representation.type, SubstanceDefinition.structure.representation.representation, SubstanceDefinition.structure.representation.format, SubstanceDefinition.structure.representation.document, SubstanceDefinition.structure.representation.document.extension, SubstanceDefinition.structure.representation.document.extension:document, SubstanceDefinition.structure.representation.document.reference, SubstanceDefinition.structure.representation.document.type, SubstanceDefinition.structure.representation.document.identifier, SubstanceDefinition.structure.representation.document.display, SubstanceDefinition.code, SubstanceDefinition.code.extension, SubstanceDefinition.code.modifierExtension, SubstanceDefinition.code.code, SubstanceDefinition.code.status, SubstanceDefinition.code.statusDate, SubstanceDefinition.code.note, SubstanceDefinition.code.source, SubstanceDefinition.code.source.extension, SubstanceDefinition.code.source.extension:source, SubstanceDefinition.code.source.reference, SubstanceDefinition.code.source.type, SubstanceDefinition.code.source.identifier, SubstanceDefinition.code.source.display, SubstanceDefinition.name, SubstanceDefinition.name.extension, SubstanceDefinition.name.extension:name, SubstanceDefinition.name.modifierExtension, SubstanceDefinition.name.name, SubstanceDefinition.name.type, SubstanceDefinition.name.status, SubstanceDefinition.name.preferred, SubstanceDefinition.name.language, SubstanceDefinition.name.domain, SubstanceDefinition.name.jurisdiction, SubstanceDefinition.name.synonym, SubstanceDefinition.name.translation, SubstanceDefinition.name.official, SubstanceDefinition.name.official.extension, SubstanceDefinition.name.official.modifierExtension, SubstanceDefinition.name.official.authority, SubstanceDefinition.name.official.status, SubstanceDefinition.name.official.date, SubstanceDefinition.name.source, SubstanceDefinition.name.source.extension, SubstanceDefinition.name.source.extension:source, SubstanceDefinition.name.source.reference, SubstanceDefinition.name.source.type, SubstanceDefinition.name.source.identifier, SubstanceDefinition.name.source.display, SubstanceDefinition.relationship, SubstanceDefinition.relationship.extension, SubstanceDefinition.relationship.modifierExtension, SubstanceDefinition.relationship.substanceDefinition[x], SubstanceDefinition.relationship.type, SubstanceDefinition.relationship.isDefining, SubstanceDefinition.relationship.amount[x], SubstanceDefinition.relationship.ratioHighLimitAmount, SubstanceDefinition.relationship.comparator, SubstanceDefinition.relationship.source, SubstanceDefinition.relationship.source.extension, SubstanceDefinition.relationship.source.extension:source, SubstanceDefinition.relationship.source.reference, SubstanceDefinition.relationship.source.type, SubstanceDefinition.relationship.source.identifier, SubstanceDefinition.relationship.source.display, SubstanceDefinition.sourceMaterial, SubstanceDefinition.sourceMaterial.extension, SubstanceDefinition.sourceMaterial.modifierExtension, SubstanceDefinition.sourceMaterial.type, SubstanceDefinition.sourceMaterial.genus, SubstanceDefinition.sourceMaterial.species, SubstanceDefinition.sourceMaterial.part, SubstanceDefinition.sourceMaterial.countryOfOrigin	All FHIR elements must have a @value or children	hasValue() or (children().count() > id.count())
ext-1	error	SubstanceDefinition.extension, SubstanceDefinition.extension:characterization, SubstanceDefinition.extension:referenceInformation, SubstanceDefinition.extension:nucleicAcid, SubstanceDefinition.extension:polymer, SubstanceDefinition.extension:protein, SubstanceDefinition.modifierExtension, SubstanceDefinition.identifier.extension, SubstanceDefinition.identifier.extension:identifier, SubstanceDefinition.version.extension, SubstanceDefinition.version.extension:version, SubstanceDefinition.status.extension, SubstanceDefinition.status.extension:status, SubstanceDefinition.description.extension, SubstanceDefinition.description.extension:description, SubstanceDefinition.moiety.extension, SubstanceDefinition.moiety.modifierExtension, SubstanceDefinition.property.extension, SubstanceDefinition.property.modifierExtension, SubstanceDefinition.molecularWeight.extension, SubstanceDefinition.molecularWeight.modifierExtension, SubstanceDefinition.structure.extension, SubstanceDefinition.structure.modifierExtension, SubstanceDefinition.structure.sourceDocument.extension, SubstanceDefinition.structure.sourceDocument.extension:sourceDocument, SubstanceDefinition.structure.representation.extension, SubstanceDefinition.structure.representation.modifierExtension, SubstanceDefinition.structure.representation.document.extension, SubstanceDefinition.structure.representation.document.extension:document, SubstanceDefinition.code.extension, SubstanceDefinition.code.modifierExtension, SubstanceDefinition.code.source.extension, SubstanceDefinition.code.source.extension:source, SubstanceDefinition.name.extension, SubstanceDefinition.name.extension:name, SubstanceDefinition.name.modifierExtension, SubstanceDefinition.name.official.extension, SubstanceDefinition.name.official.modifierExtension, SubstanceDefinition.name.source.extension, SubstanceDefinition.name.source.extension:source, SubstanceDefinition.relationship.extension, SubstanceDefinition.relationship.modifierExtension, SubstanceDefinition.relationship.source.extension, SubstanceDefinition.relationship.source.extension:source, SubstanceDefinition.sourceMaterial.extension, SubstanceDefinition.sourceMaterial.modifierExtension	Must have either extensions or value[x], not both	extension.exists() != value.exists()

This structure is derived from SubstanceDefinition

Summary

Extensions

This structure refers to these extensions:

• http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.characterization|0.1.0
• http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.referenceInformation|0.1.0
• http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.nucleicAcid|0.1.0
• http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.polymer|0.1.0
• http://hl7.org/fhir/5.0/StructureDefinition/extension-SubstanceDefinition.protein|0.1.0
• http://hl7.org/fhir/StructureDefinition/artifact-identifier|5.2.0
• http://hl7.org/fhir/StructureDefinition/artifact-version|5.2.0
• http://hl7.org/fhir/StructureDefinition/artifact-status|5.2.0
• http://hl7.org/fhir/StructureDefinition/artifact-description|5.2.0
• http://hl7.org/fhir/StructureDefinition/alternate-reference|5.2.0
• http://hl7.org/fhir/StructureDefinition/artifact-name|5.2.0

Maturity: 0