Pharmaceutical Quality (Industry)
1.0.0 - STU1
Pharmaceutical Quality (Industry)
1.0.0 - STU1
This page is part of the Pharmaceutical Quality (Industry) (v1.0.0: STU1) based on FHIR (HL7® FHIR® Standard) v5.0.0. This is the current published version in its permanent home (it will always be available at this URL). For a full list of available versions, see the Directory of published versions
<!-- Substance Batch Analysis -->
<Bundle xmlns="http://hl7.org/fhir">
<id value="bundle-batch-analysis-pq-ex2-sub"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Bundle-batch-analysis-pq"/>
</meta>
<type value="collection"/>
<entry>
<fullUrl value="urn:uuid:2038e4c7-22b8-4c56-2d28-6c077648763f"/>
<resource>
<PlanDefinition>
<!-- specificationProtocol -->
<id value="2038e4c7-22b8-4c56-2d28-6c077648763f"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/PlanDefinition-drug-pq"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="PlanDefinition_2038e4c7-22b8-4c56-2d28-6c077648763f"> </a><p><b>Generated Narrative: PlanDefinition</b><a name="2038e4c7-22b8-4c56-2d28-6c077648763f"> </a><a name="hc2038e4c7-22b8-4c56-2d28-6c077648763f"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource PlanDefinition "2038e4c7-22b8-4c56-2d28-6c077648763f" </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-PlanDefinition-drug-pq.html">PlanDefinition - Drug PQ</a></p></div><p><b>url</b>: <code>http://example-server.com/fhir/PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f</code></p><p><b>title</b>: S.4.4 BATCH ANALYSIS</p><p><b>type</b>: Specification Protocol <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-pharmaceutical-plan-type.html">Pharmaceutical Plan Type Codes</a>#1244577)</span></p><p><b>status</b>: active</p><p><b>subject</b>: See on this page: SubstanceDefinition/8dae93e0-048d-35a4-71ea-7c603184a130</p><p><b>description</b>: Narrative description of analysis</p><blockquote><p><b>action</b></p><p><b>title</b>: Batch Specification for Drug Substance</p><p><b>code</b>: Overall set of actions <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><h3>Actions</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Definition[x]</b></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><a href="http://example-server.com/fhir/ObservationDefinition/13033a89-927a-10e0-503e-5f901bdca30f">http://example-server.com/fhir/ObservationDefinition/13033a89-927a-10e0-503e-5f901bdca30f</a></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><a href="http://example-server.com/fhir/ObservationDefinition/8395ae1d-5064-0ab7-a297-6b20285b2230">http://example-server.com/fhir/ObservationDefinition/8395ae1d-5064-0ab7-a297-6b20285b2230</a></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><a href="http://example-server.com/fhir/ObservationDefinition/2117208e-4185-9091-1f86-cce37b121838">http://example-server.com/fhir/ObservationDefinition/2117208e-4185-9091-1f86-cce37b121838</a></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><a href="http://example-server.com/fhir/ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8">http://example-server.com/fhir/ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8</a></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><a href="http://example-server.com/fhir/ObservationDefinition/0634020c-8729-99fc-7637-89799d7c445b">http://example-server.com/fhir/ObservationDefinition/0634020c-8729-99fc-7637-89799d7c445b</a></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><a href="http://example-server.com/fhir/ObservationDefinition/4e67725b-20c8-158e-9d53-1810bfa58d87">http://example-server.com/fhir/ObservationDefinition/4e67725b-20c8-158e-9d53-1810bfa58d87</a></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><a href="http://example-server.com/fhir/ObservationDefinition/2daba8ca-211f-4f4b-4028-16c30fe22ee8">http://example-server.com/fhir/ObservationDefinition/2daba8ca-211f-4f4b-4028-16c30fe22ee8</a></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><a href="http://example-server.com/fhir/ObservationDefinition/17b322fe-53ea-6c1f-521b-3b148ac05eb4">http://example-server.com/fhir/ObservationDefinition/17b322fe-53ea-6c1f-521b-3b148ac05eb4</a></td></tr><tr><td style="display: none">*</td><td>Test <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td><a href="http://example-server.com/fhir/ObservationDefinition/11fcfe6b-7498-132b-2def-efae51b302d4">http://example-server.com/fhir/ObservationDefinition/11fcfe6b-7498-132b-2def-efae51b302d4</a></td></tr></table></blockquote></div>
</text>
<!-- http://example-server.com/fhir/PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f -->
<url
value="http://example-server.com/fhir/PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f"/>
<title value="S.4.4 BATCH ANALYSIS"/>
<type>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/pharmaceutical-plan-type"/>
<code value="1244577"/>
<display value="Specification Protocol"/>
</coding>
</type>
<status value="active"/>
<subjectReference>
<!-- SubstanceDefinition/substance1 -->
<reference
value="SubstanceDefinition/8dae93e0-048d-35a4-71ea-7c603184a130"/>
</subjectReference>
<description value="Narrative description of analysis"/>
<action>
<!-- this is then entire thing -->
<title value="Batch Specification for Drug Substance"/>
<code>
<text value="Overall set of actions"/>
</code>
<action>
<code>
<text value="Test"/>
</code>
<!-- ObservationDefinition/Description -->
<definitionCanonical
value="http://example-server.com/fhir/ObservationDefinition/13033a89-927a-10e0-503e-5f901bdca30f"/>
</action>
<action>
<code>
<text value="Test"/>
</code>
<!-- ObservationDefinition/Identification -->
<definitionCanonical
value="http://example-server.com/fhir/ObservationDefinition/8395ae1d-5064-0ab7-a297-6b20285b2230"/>
</action>
<action>
<code>
<text value="Test"/>
</code>
<!-- ObservationDefinition/Assay -->
<definitionCanonical
value="http://example-server.com/fhir/ObservationDefinition/2117208e-4185-9091-1f86-cce37b121838"/>
</action>
<action>
<code>
<text value="Test"/>
</code>
<!-- ObservationDefinition/Impurities -->
<definitionCanonical
value="http://example-server.com/fhir/ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8"/>
</action>
<action>
<code>
<text value="Test"/>
</code>
<!-- ObservationDefinition/Mutagenic -->
<definitionCanonical
value="http://example-server.com/fhir/ObservationDefinition/0634020c-8729-99fc-7637-89799d7c445b"/>
</action>
<action>
<code>
<text value="Test"/>
</code>
<!-- ObservationDefinition/Enantiomeric -->
<definitionCanonical
value="http://example-server.com/fhir/ObservationDefinition/4e67725b-20c8-158e-9d53-1810bfa58d87"/>
</action>
<action>
<code>
<text value="Test"/>
</code>
<!-- ObservationDefinition/Solvents -->
<definitionCanonical
value="http://example-server.com/fhir/ObservationDefinition/2daba8ca-211f-4f4b-4028-16c30fe22ee8"/>
</action>
<action>
<code>
<text value="Test"/>
</code>
<!-- ObservationDefinition/Water -->
<definitionCanonical
value="http://example-server.com/fhir/ObservationDefinition/17b322fe-53ea-6c1f-521b-3b148ac05eb4"/>
</action>
<action>
<code>
<text value="Test"/>
</code>
<!-- ObservationDefinition/Particles -->
<definitionCanonical
value="http://example-server.com/fhir/ObservationDefinition/11fcfe6b-7498-132b-2def-efae51b302d4"/>
</action>
</action>
</PlanDefinition>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:13033a89-927a-10e0-503e-5f901bdca30f"/>
<resource>
<ObservationDefinition>
<!-- Description -->
<id value="13033a89-927a-10e0-503e-5f901bdca30f"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="ObservationDefinition_13033a89-927a-10e0-503e-5f901bdca30f"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name="13033a89-927a-10e0-503e-5f901bdca30f"> </a><a name="hc13033a89-927a-10e0-503e-5f901bdca30f"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition "13033a89-927a-10e0-503e-5f901bdca30f" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/13033a89-927a-10e0-503e-5f901bdca30f</code></p><p><b>title</b>: Description</p><p><b>status</b>: active</p><p><b>code</b>: Description <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#DESC)</span></p><p><b>method</b>: Visual inspection <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><h3>QualifiedValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Extension</b></td></tr><tr><td style="display: none">*</td><td/></tr></table></div>
</text>
<!-- http://example-server.com/fhir/ObservationDefinition/13033a89-927a-10e0-503e-5f901bdca30f -->
<url
value="http://example-server.com/fhir/ObservationDefinition/13033a89-927a-10e0-503e-5f901bdca30f"/>
<title value="Description"/>
<status value="active"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="DESC"/>
<display value="Description"/>
</coding>
<text value="Description"/>
</code>
<method>
<text value="Visual inspection"/>
</method>
<qualifiedValue>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-text-pq">
<valueString value="A white to brown powder"/>
</extension>
</qualifiedValue>
</ObservationDefinition>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:8395ae1d-5064-0ab7-a297-6b20285b2230"/>
<resource>
<ObservationDefinition>
<!-- Identification -->
<id value="8395ae1d-5064-0ab7-a297-6b20285b2230"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="ObservationDefinition_8395ae1d-5064-0ab7-a297-6b20285b2230"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name="8395ae1d-5064-0ab7-a297-6b20285b2230"> </a><a name="hc8395ae1d-5064-0ab7-a297-6b20285b2230"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition "8395ae1d-5064-0ab7-a297-6b20285b2230" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/8395ae1d-5064-0ab7-a297-6b20285b2230</code></p><p><b>title</b>: Identification</p><p><b>status</b>: active</p><p><b>code</b>: Identification <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IDT)</span></p><p><b>method</b>: Identification by IR spectroscopy Identification by HPLC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><h3>QualifiedValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Extension</b></td></tr><tr><td style="display: none">*</td><td/></tr></table></div>
</text>
<!-- http://example-server.com/fhir/ObservationDefinition/8395ae1d-5064-0ab7-a297-6b20285b2230 -->
<url
value="http://example-server.com/fhir/ObservationDefinition/8395ae1d-5064-0ab7-a297-6b20285b2230"/>
<title value="Identification"/>
<status value="active"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="IDT"/>
<display value="Identification"/>
</coding>
<text value="Identification"/>
</code>
<method>
<text
value="Identification by IR spectroscopy Identification by HPLC"/>
</method>
<qualifiedValue>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-qualified-value-text-pq">
<valueString value="Conforms with reference"/>
</extension>
</qualifiedValue>
</ObservationDefinition>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:2117208e-4185-9091-1f86-cce37b121838"/>
<resource>
<ObservationDefinition>
<!-- Assay -->
<id value="2117208e-4185-9091-1f86-cce37b121838"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="ObservationDefinition_2117208e-4185-9091-1f86-cce37b121838"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name="2117208e-4185-9091-1f86-cce37b121838"> </a><a name="hc2117208e-4185-9091-1f86-cce37b121838"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition "2117208e-4185-9091-1f86-cce37b121838" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/2117208e-4185-9091-1f86-cce37b121838</code></p><p><b>title</b>: Assay</p><p><b>status</b>: active</p><p><b>code</b>: Assay <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#ASSAY)</span></p><p><b>method</b>: Assay by LC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><h3>QualifiedValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Range</b></td></tr><tr><td style="display: none">*</td><td>98-102 % w/w</td></tr></table></div>
</text>
<!-- http://example-server.com/fhir/ObservationDefinition/2117208e-4185-9091-1f86-cce37b121838 -->
<url
value="http://example-server.com/fhir/ObservationDefinition/2117208e-4185-9091-1f86-cce37b121838"/>
<title value="Assay"/>
<status value="active"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="ASSAY"/>
<display value="Assay"/>
</coding>
<text value="Assay"/>
</code>
<method>
<text value="Assay by LC"/>
</method>
<qualifiedValue>
<range>
<low>
<value value="98"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</low>
<high>
<value value="102"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</high>
</range>
</qualifiedValue>
</ObservationDefinition>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:d04e0f2a-6ee7-6c2e-1db8-7df394c927b8"/>
<resource>
<ObservationDefinition>
<!-- Impurities -->
<id value="d04e0f2a-6ee7-6c2e-1db8-7df394c927b8"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="ObservationDefinition_d04e0f2a-6ee7-6c2e-1db8-7df394c927b8"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name="d04e0f2a-6ee7-6c2e-1db8-7df394c927b8"> </a><a name="hcd04e0f2a-6ee7-6c2e-1db8-7df394c927b8"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition "d04e0f2a-6ee7-6c2e-1db8-7df394c927b8" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8</code></p><p><b>title</b>: Drug Substance Related Organic impurities</p><p><b>status</b>: active</p><p><b>code</b>: Drug Substance Related Organic impurities <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#DGP-s)</span></p><p><b>method</b>: Organic impurities by LC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><blockquote><p><b>qualifiedValue</b></p><p><b>appliesTo</b>: Impurity 1 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><p><b>range</b>: ?-0.5</p></blockquote><blockquote><p><b>qualifiedValue</b></p><p><b>appliesTo</b>: Impurity 2 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><p><b>range</b>: ?-0.5</p></blockquote><blockquote><p><b>qualifiedValue</b></p><p><b>appliesTo</b>: Impurity 3 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><p><b>range</b>: ?-0.5</p></blockquote><blockquote><p><b>qualifiedValue</b></p><p><b>appliesTo</b>: Any individual unspecified impurity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><p><b>range</b>: ?-0.10</p></blockquote><blockquote><p><b>qualifiedValue</b></p><p><b>appliesTo</b>: Total impurities <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><p><b>range</b>: ?-2.0</p></blockquote><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td></tr><tr><td style="display: none">*</td><td>Impurity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IMP)</span></td></tr></table></div>
</text>
<!-- <meta>
<profile value="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/ObservationDefinition-test-method-drug-pq"/>
</meta> -->
<!-- http://example-server.com/fhir/ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8 -->
<url
value="http://example-server.com/fhir/ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8"/>
<title value="Drug Substance Related Organic impurities"/>
<status value="active"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="DGP-s"/>
<display value="Drug Substance Related Organic impurities"/>
</coding>
</code>
<method>
<text value="Organic impurities by LC"/>
</method>
<qualifiedValue>
<appliesTo>
<!-- could be a code -->
<text value="Impurity 1"/>
</appliesTo>
<range>
<high>
<value value="0.5"/>
<unit value="% w/w"/>
</high>
</range>
</qualifiedValue>
<qualifiedValue>
<appliesTo>
<text value="Impurity 2"/>
</appliesTo>
<range>
<high>
<value value="0.5"/>
<unit value="% w/w"/>
</high>
</range>
</qualifiedValue>
<qualifiedValue>
<appliesTo>
<text value="Impurity 3">
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-test-comment-pq">
<valueString
value="Impurity 3 was included in the release specification throughout clinical development, and no longer forms a part of a commercial release specification; see Section S.4.5 Justification of Specification and Section S.2.5 Validation (PPQ) for additional data"/>
</extension>
</text>
</appliesTo>
<range>
<high>
<value value="0.5"/>
<unit value="% w/w"/>
</high>
</range>
</qualifiedValue>
<qualifiedValue>
<appliesTo>
<text value="Any individual unspecified impurity"/>
</appliesTo>
<range>
<high>
<value value="0.10"/>
<unit value="% w/w"/>
</high>
</range>
</qualifiedValue>
<qualifiedValue>
<appliesTo>
<text value="Total impurities"/>
</appliesTo>
<range>
<high>
<value value="2.0"/>
<unit value="% w/w"/>
</high>
</range>
</qualifiedValue>
<component>
<!-- are expected to have a component that says what impurity this one is -->
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="IMP"/>
<display value="Impurity"/>
</coding>
</code>
</component>
</ObservationDefinition>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:0634020c-8729-99fc-7637-89799d7c445b"/>
<resource>
<ObservationDefinition>
<!-- Mutagenic -->
<id value="0634020c-8729-99fc-7637-89799d7c445b"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="ObservationDefinition_0634020c-8729-99fc-7637-89799d7c445b"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name="0634020c-8729-99fc-7637-89799d7c445b"> </a><a name="hc0634020c-8729-99fc-7637-89799d7c445b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition "0634020c-8729-99fc-7637-89799d7c445b" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/0634020c-8729-99fc-7637-89799d7c445b</code></p><p><b>title</b>: Mutagenic impurities</p><p><b>status</b>: active</p><p><b>code</b>: Mutagenic impurities <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#MUT)</span></p><p><b>method</b>: Impurity 5 content by LC-MS <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><h3>QualifiedValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>AppliesTo</b></td><td><b>Range</b></td></tr><tr><td style="display: none">*</td><td>Impurity - Mutagenic <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td><td>?-50</td></tr></table><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td></tr><tr><td style="display: none">*</td><td>Impurity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IMP)</span></td></tr></table></div>
</text>
<!-- http://example-server.com/fhir/ObservationDefinition/0634020c-8729-99fc-7637-89799d7c445b -->
<url
value="http://example-server.com/fhir/ObservationDefinition/0634020c-8729-99fc-7637-89799d7c445b"/>
<title value="Mutagenic impurities"/>
<status value="active"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="MUT"/>
<display value="Mutagenic impurities"/>
</coding>
</code>
<method>
<text value="Impurity 5 content by LC-MS"/>
</method>
<qualifiedValue>
<appliesTo>
<!-- could be a code -->
<text value="Impurity - Mutagenic"/>
</appliesTo>
<range>
<high>
<value value="50"/>
<unit value="ppm"/>
<system value="http://unitsofmeasure.org"/>
<code value="[ppm]"/>
</high>
</range>
</qualifiedValue>
<component>
<!-- are expected to have a component that says what impurity this one is -->
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="IMP"/>
<display value="Impurity"/>
</coding>
</code>
</component>
</ObservationDefinition>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:4e67725b-20c8-158e-9d53-1810bfa58d87"/>
<resource>
<ObservationDefinition>
<!-- Enantiomeric -->
<id value="4e67725b-20c8-158e-9d53-1810bfa58d87"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="ObservationDefinition_4e67725b-20c8-158e-9d53-1810bfa58d87"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name="4e67725b-20c8-158e-9d53-1810bfa58d87"> </a><a name="hc4e67725b-20c8-158e-9d53-1810bfa58d87"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition "4e67725b-20c8-158e-9d53-1810bfa58d87" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/4e67725b-20c8-158e-9d53-1810bfa58d87</code></p><p><b>title</b>: Enantiomeric purity</p><p><b>status</b>: active</p><p><b>code</b>: Enantiomeric purity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#enantiomeric-purity)</span></p><p><b>method</b>: Enantiomeric purity by LC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><h3>QualifiedValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Range</b></td></tr><tr><td style="display: none">*</td><td>99.6-? %</td></tr></table></div>
</text>
<!-- http://example-server.com/fhir/ObservationDefinition/4e67725b-20c8-158e-9d53-1810bfa58d87 -->
<url
value="http://example-server.com/fhir/ObservationDefinition/4e67725b-20c8-158e-9d53-1810bfa58d87"/>
<title value="Enantiomeric purity"/>
<status value="active"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="enantiomeric-purity"/>
<display value="Enantiomeric purity"/>
</coding>
<text value="Enantiomeric purity"/>
</code>
<method>
<text value="Enantiomeric purity by LC"/>
</method>
<qualifiedValue>
<range>
<low>
<value value="99.6"/>
<unit value="%"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</low>
</range>
</qualifiedValue>
</ObservationDefinition>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:2daba8ca-211f-4f4b-4028-16c30fe22ee8"/>
<resource>
<ObservationDefinition>
<!-- Solvents -->
<id value="2daba8ca-211f-4f4b-4028-16c30fe22ee8"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="ObservationDefinition_2daba8ca-211f-4f4b-4028-16c30fe22ee8"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name="2daba8ca-211f-4f4b-4028-16c30fe22ee8"> </a><a name="hc2daba8ca-211f-4f4b-4028-16c30fe22ee8"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition "2daba8ca-211f-4f4b-4028-16c30fe22ee8" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/2daba8ca-211f-4f4b-4028-16c30fe22ee8</code></p><p><b>title</b>: Residual solvents</p><p><b>status</b>: active</p><p><b>code</b>: Residual solvents <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#SOL)</span></p><p><b>method</b>: Residual solvents by headspace GC <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><blockquote><p><b>qualifiedValue</b></p><p><b>appliesTo</b>: Solvent 1 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><p><b>range</b>: ?-0.1</p></blockquote><blockquote><p><b>qualifiedValue</b></p><p><b>appliesTo</b>: Solvent 2 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><p><b>range</b>: ?-2.0</p></blockquote><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td></tr><tr><td style="display: none">*</td><td>Solvent <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#SOLV)</span></td></tr></table></div>
</text>
<!-- http://example-server.com/fhir/ObservationDefinition/2daba8ca-211f-4f4b-4028-16c30fe22ee8 -->
<url
value="http://example-server.com/fhir/ObservationDefinition/2daba8ca-211f-4f4b-4028-16c30fe22ee8"/>
<title value="Residual solvents"/>
<status value="active"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="SOL"/>
<display value="Residual solvents"/>
</coding>
</code>
<method>
<text value="Residual solvents by headspace GC"/>
</method>
<qualifiedValue>
<appliesTo>
<!-- could be a code -->
<text value="Solvent 1"/>
</appliesTo>
<range>
<high>
<value value="0.1"/>
<unit value="% w/w"/>
</high>
</range>
</qualifiedValue>
<qualifiedValue>
<appliesTo>
<text value="Solvent 2"/>
</appliesTo>
<range>
<high>
<value value="2.0"/>
<unit value="% w/w"/>
</high>
</range>
</qualifiedValue>
<component>
<!-- are expected to have a component that says what solvent this one is -->
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="SOLV"/>
<display value="Solvent"/>
</coding>
</code>
</component>
</ObservationDefinition>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:17b322fe-53ea-6c1f-521b-3b148ac05eb4"/>
<resource>
<ObservationDefinition>
<!-- Water -->
<id value="17b322fe-53ea-6c1f-521b-3b148ac05eb4"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="ObservationDefinition_17b322fe-53ea-6c1f-521b-3b148ac05eb4"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name="17b322fe-53ea-6c1f-521b-3b148ac05eb4"> </a><a name="hc17b322fe-53ea-6c1f-521b-3b148ac05eb4"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition "17b322fe-53ea-6c1f-521b-3b148ac05eb4" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/17b322fe-53ea-6c1f-521b-3b148ac05eb4</code></p><p><b>title</b>: Water Content</p><p><b>status</b>: active</p><p><b>code</b>: Water Content <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#WaterContent)</span></p><p><b>method</b>: USP Karl Fischer titration <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><h3>QualifiedValues</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Range</b></td></tr><tr><td style="display: none">*</td><td>?-1.0</td></tr></table></div>
</text>
<!-- http://example-server.com/fhir/ObservationDefinition/17b322fe-53ea-6c1f-521b-3b148ac05eb4 -->
<url
value="http://example-server.com/fhir/ObservationDefinition/17b322fe-53ea-6c1f-521b-3b148ac05eb4"/>
<title value="Water Content"/>
<status value="active"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="WaterContent"/>
<display value="Water Content"/>
</coding>
<text value="Water Content"/>
</code>
<method>
<text value="USP Karl Fischer titration"/>
</method>
<qualifiedValue>
<range>
<high>
<value value="1.0"/>
<unit value="% w/w"/>
</high>
</range>
</qualifiedValue>
</ObservationDefinition>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:11fcfe6b-7498-132b-2def-efae51b302d4"/>
<resource>
<ObservationDefinition>
<!-- Particles -->
<id value="11fcfe6b-7498-132b-2def-efae51b302d4"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="ObservationDefinition_11fcfe6b-7498-132b-2def-efae51b302d4"> </a><p><b>Generated Narrative: ObservationDefinition</b><a name="11fcfe6b-7498-132b-2def-efae51b302d4"> </a><a name="hc11fcfe6b-7498-132b-2def-efae51b302d4"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ObservationDefinition "11fcfe6b-7498-132b-2def-efae51b302d4" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/ObservationDefinition/11fcfe6b-7498-132b-2def-efae51b302d4</code></p><p><b>title</b>: Particle size distribution</p><p><b>status</b>: active</p><p><b>code</b>: Particle size distribution <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#PART)</span></p><p><b>method</b>: Laser diffraction <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><blockquote><p><b>qualifiedValue</b></p><p><b>appliesTo</b>: D(v,0.9) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><p><b>range</b>: ?-319</p></blockquote><blockquote><p><b>qualifiedValue</b></p><p><b>appliesTo</b>: D(v,0.5) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><p><b>range</b>: ?-145</p></blockquote><blockquote><p><b>qualifiedValue</b></p><p><b>appliesTo</b>: D(v,0.1) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p><p><b>range</b>: ?-20</p></blockquote><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td></tr><tr><td style="display: none">*</td><td>Particle size <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#PARTS)</span></td></tr></table></div>
</text>
<!-- http://example-server.com/fhir/ObservationDefinition/11fcfe6b-7498-132b-2def-efae51b302d4 -->
<url
value="http://example-server.com/fhir/ObservationDefinition/11fcfe6b-7498-132b-2def-efae51b302d4"/>
<title value="Particle size distribution">
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-test-comment-pq">
<valueString
value="Particle Size Distribution was included in the release specification throughout clinical development, and no longer forms a part of the commercial release specification; See Section S.4.5 Justification of Specification for data and rationale."/>
</extension>
</title>
<status value="active"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="PART"/>
<display value="Particle size distribution"/>
</coding>
</code>
<method>
<text value="Laser diffraction"/>
</method>
<qualifiedValue>
<appliesTo>
<!-- could be a code -->
<text value="D(v,0.9)"/>
</appliesTo>
<range>
<high>
<value value="319"/>
<unit value="µm"/>
<system value="http://unitsofmeasure.org"/>
<code value="um"/>
</high>
</range>
</qualifiedValue>
<qualifiedValue>
<appliesTo>
<!-- could be a code -->
<text value="D(v,0.5)"/>
</appliesTo>
<range>
<high>
<value value="145"/>
<unit value="µm"/>
<system value="http://unitsofmeasure.org"/>
<code value="um"/>
</high>
</range>
</qualifiedValue>
<qualifiedValue>
<appliesTo>
<!-- could be a code -->
<text value="D(v,0.1)"/>
</appliesTo>
<range>
<high>
<value value="20"/>
<unit value="µm"/>
<system value="http://unitsofmeasure.org"/>
<code value="um"/>
</high>
</range>
</qualifiedValue>
<component>
<!-- are expected to have a component that says what solvent this one is -->
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="PARTS"/>
<display value="Particle size"/>
</coding>
</code>
</component>
</ObservationDefinition>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:87ef899b-14dd-26b7-7416-7ec1d01b62a1"/>
<resource>
<Substance>
<!-- substance-drug-pq-ex1 -->
<id value="87ef899b-14dd-26b7-7416-7ec1d01b62a1"/>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_87ef899b-14dd-26b7-7416-7ec1d01b62a1"> </a><p><b>Generated Narrative: Substance</b><a name="87ef899b-14dd-26b7-7416-7ec1d01b62a1"> </a><a name="hc87ef899b-14dd-26b7-7416-7ec1d01b62a1"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance "87ef899b-14dd-26b7-7416-7ec1d01b62a1" </p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 120 kg</p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2020-01</p><blockquote><p><b>url</b></p><code>batchUtilization</code></blockquote><p><b>value</b>: Production <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.0.0/CodeSystem-v3-nciThesaurus.html">NCI Thesaurus</a>#C133990 "Commercial")</span></p><blockquote><p><b>url</b></p><code>assignedManufacturer</code></blockquote><p><b>value</b>: See on this page: Organization/3d399cbc-244e-9b5f-838b-b7daa0489330</p></blockquote><p><b>Extension - Batch Release Date PQ</b>: 2019-09-08</p><p><b>Extension - Batch Retest Date PQ</b>: 2022-09-08</p><p><b>Extension - Manufacturing Process PQ</b>: See on this page: PlanDefinition/b30a1024-37db-a1bc-05e5-cc4596d92975</p><p><b>Extension - Actual Yield PQ</b>: 4.8 kg</p><p><b>identifier</b>: CAT1</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/8dae93e0-048d-35a4-71ea-7c603184a130</td></tr></table></div>
</text>
<!-- was actual-batch-substance -->
<extension
url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
<extension url="batchQuantity">
<valueQuantity>
<value value="120"/>
<unit value="kg"/>
</valueQuantity>
</extension>
<extension url="manufacturingDate">
<valueDateTime value="2020-01"/>
</extension>
<extension url="batchUtilization">
<valueCodeableConcept>
<!-- could also be C185328 Stability Study? -->
<coding>
<system
value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"/>
<code value="C133990"/>
<display value="Commercial"/>
</coding>
<text value="Production"/>
</valueCodeableConcept>
</extension>
<extension url="assignedManufacturer">
<valueReference>
<!-- Organization/substance-manufacturer -->
<reference
value="Organization/3d399cbc-244e-9b5f-838b-b7daa0489330"/>
</valueReference>
</extension>
</extension>
<!-- local extensions -->
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq">
<valueDateTime value="2019-09-08"/>
</extension>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-retest-date-pq">
<valueDateTime value="2022-09-08"/>
</extension>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-manufacturing-process-pq">
<valueReference>
<!-- PlanDefinition/plandefinition-dxpq-ex4-mnf-process -->
<reference
value="PlanDefinition/b30a1024-37db-a1bc-05e5-cc4596d92975"/>
</valueReference>
</extension>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq">
<valueQuantity>
<value value="4.8"/>
<unit value="kg"/>
</valueQuantity>
</extension>
<identifier>
<value value="CAT1"/>
</identifier>
<instance value="true"/>
<code>
<reference>
<!-- SubstanceDefinition/substance1 -->
<reference
value="SubstanceDefinition/8dae93e0-048d-35a4-71ea-7c603184a130"/>
</reference>
</code>
</Substance>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:6412c5d4-1b7d-8405-85dc-75dbaa300ea4"/>
<resource>
<Substance>
<!-- actual-batch-substance-2 -->
<id value="6412c5d4-1b7d-8405-85dc-75dbaa300ea4"/>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_6412c5d4-1b7d-8405-85dc-75dbaa300ea4"> </a><p><b>Generated Narrative: Substance</b><a name="6412c5d4-1b7d-8405-85dc-75dbaa300ea4"> </a><a name="hc6412c5d4-1b7d-8405-85dc-75dbaa300ea4"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance "6412c5d4-1b7d-8405-85dc-75dbaa300ea4" </p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2020-02</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 120 kg</p><blockquote><p><b>url</b></p><code>batchUtilization</code></blockquote><p><b>value</b>: Production <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.0.0/CodeSystem-v3-nciThesaurus.html">NCI Thesaurus</a>#C133990 "Commercial")</span></p><blockquote><p><b>url</b></p><code>assignedManufacturer</code></blockquote><p><b>value</b>: See on this page: Organization/3d399cbc-244e-9b5f-838b-b7daa0489330</p></blockquote><p><b>Extension - Batch Release Date PQ</b>: 2019-09-08</p><p><b>Extension - Batch Retest Date PQ</b>: 2022-09-08</p><p><b>Extension - Actual Yield PQ</b>: 4.8 kg</p><p><b>identifier</b>: CAT2</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/8dae93e0-048d-35a4-71ea-7c603184a130</td></tr></table></div>
</text>
<extension
url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
<extension url="manufacturingDate">
<valueDateTime value="2020-02"/>
</extension>
<extension url="batchQuantity">
<valueQuantity>
<value value="120"/>
<unit value="kg"/>
</valueQuantity>
</extension>
<extension url="batchUtilization">
<valueCodeableConcept>
<!-- could also be C185328 Stability Study? -->
<coding>
<system
value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"/>
<code value="C133990"/>
<display value="Commercial"/>
</coding>
<text value="Production"/>
</valueCodeableConcept>
</extension>
<extension url="assignedManufacturer">
<valueReference>
<!-- Organization/substance-manufacturer -->
<reference
value="Organization/3d399cbc-244e-9b5f-838b-b7daa0489330"/>
</valueReference>
</extension>
</extension>
<!-- local extensions -->
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq">
<valueDateTime value="2019-09-08"/>
</extension>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-retest-date-pq">
<valueDateTime value="2022-09-08"/>
</extension>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq">
<valueQuantity>
<value value="4.8"/>
<unit value="kg"/>
</valueQuantity>
</extension>
<identifier>
<value value="CAT2"/>
</identifier>
<instance value="true"/>
<code>
<reference>
<!-- SubstanceDefinition/substance1 -->
<reference
value="SubstanceDefinition/8dae93e0-048d-35a4-71ea-7c603184a130"/>
</reference>
</code>
</Substance>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:ef17cff1-6586-a4a4-9168-2602140548d7"/>
<resource>
<Substance>
<!-- actual-batch-substance-3 -->
<id value="ef17cff1-6586-a4a4-9168-2602140548d7"/>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Substance_ef17cff1-6586-a4a4-9168-2602140548d7"> </a><p><b>Generated Narrative: Substance</b><a name="ef17cff1-6586-a4a4-9168-2602140548d7"> </a><a name="hcef17cff1-6586-a4a4-9168-2602140548d7"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Substance "ef17cff1-6586-a4a4-9168-2602140548d7" </p></div><blockquote><p><b>Medication Manufacturing Batch</b></p><blockquote><p><b>url</b></p><code>manufacturingDate</code></blockquote><p><b>value</b>: 2020-03</p><blockquote><p><b>url</b></p><code>batchQuantity</code></blockquote><p><b>value</b>: 120 kg</p><blockquote><p><b>url</b></p><code>batchUtilization</code></blockquote><p><b>value</b>: Production <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.0.0/CodeSystem-v3-nciThesaurus.html">NCI Thesaurus</a>#C133990 "Commercial")</span></p><blockquote><p><b>url</b></p><code>assignedManufacturer</code></blockquote><p><b>value</b>: See on this page: Organization/3d399cbc-244e-9b5f-838b-b7daa0489330</p></blockquote><p><b>Extension - Batch Release Date PQ</b>: 2019-09-08</p><p><b>Extension - Batch Retest Date PQ</b>: 2022-09-08</p><p><b>Extension - Actual Yield PQ</b>: 4.8 kg</p><p><b>identifier</b>: CAT3</p><p><b>instance</b>: true</p><h3>Codes</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Reference</b></td></tr><tr><td style="display: none">*</td><td>See on this page: SubstanceDefinition/8dae93e0-048d-35a4-71ea-7c603184a130</td></tr></table></div>
</text>
<extension
url="http://hl7.org/fhir/StructureDefinition/medication-manufacturingBatch">
<extension url="manufacturingDate">
<valueDateTime value="2020-03"/>
</extension>
<extension url="batchQuantity">
<valueQuantity>
<value value="120"/>
<unit value="kg"/>
</valueQuantity>
</extension>
<extension url="batchUtilization">
<valueCodeableConcept>
<coding>
<system
value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"/>
<code value="C133990"/>
<display value="Commercial"/>
</coding>
<text value="Production"/>
</valueCodeableConcept>
</extension>
<extension url="assignedManufacturer">
<valueReference>
<!-- Organization/substance-manufacturer -->
<reference
value="Organization/3d399cbc-244e-9b5f-838b-b7daa0489330"/>
</valueReference>
</extension>
</extension>
<!-- local extensions -->
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-release-date-pq">
<valueDateTime value="2019-09-08"/>
</extension>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-batch-retest-date-pq">
<valueDateTime value="2022-09-08"/>
</extension>
<extension
url="http://hl7.org/fhir/uv/pharm-quality/StructureDefinition/Extension-actual-yield-pq">
<valueQuantity>
<value value="4.8"/>
<unit value="kg"/>
</valueQuantity>
</extension>
<identifier>
<value value="CAT3"/>
</identifier>
<instance value="true"/>
<code>
<reference>
<!-- SubstanceDefinition/substance1 -->
<reference
value="SubstanceDefinition/8dae93e0-048d-35a4-71ea-7c603184a130"/>
</reference>
</code>
</Substance>
</resource>
</entry>
<!-- Section 5 - Manufacturing Process -->
<entry>
<fullUrl value="urn:uuid:b30a1024-37db-a1bc-05e5-cc4596d92975"/>
<resource>
<PlanDefinition>
<!-- id value="manufacturingProcess"/ -->
<!-- plandefinition-dxpq-ex4-mnf-process -->
<id value="b30a1024-37db-a1bc-05e5-cc4596d92975"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="PlanDefinition_b30a1024-37db-a1bc-05e5-cc4596d92975"> </a><p><b>Generated Narrative: PlanDefinition</b><a name="b30a1024-37db-a1bc-05e5-cc4596d92975"> </a><a name="hcb30a1024-37db-a1bc-05e5-cc4596d92975"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource PlanDefinition "b30a1024-37db-a1bc-05e5-cc4596d92975" </p></div><p><b>url</b>: <code>http://example-server.com/fhir/PlanDefinition/b30a1024-37db-a1bc-05e5-cc4596d92975</code></p><p><b>title</b>: Process 1.1</p><p><b>type</b>: Manufacturing Process <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-pharmaceutical-plan-type.html">Pharmaceutical Plan Type Codes</a>#1244566)</span></p><p><b>status</b>: active</p><p><b>subject</b>: See on this page: SubstanceDefinition/8dae93e0-048d-35a4-71ea-7c603184a130</p></div>
</text>
<!-- http://example-server.com/fhir/PlanDefinition/b30a1024-37db-a1bc-05e5-cc4596d92975 -->
<url
value="http://example-server.com/fhir/PlanDefinition/b30a1024-37db-a1bc-05e5-cc4596d92975"/>
<title value="Process 1.1"/>
<type>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/pharmaceutical-plan-type"/>
<code value="1244566"/>
<display value="Manufacturing Process"/>
</coding>
</type>
<status value="active"/>
<subjectReference>
<!-- SubstanceDefinition/substance1 -->
<reference
value="SubstanceDefinition/8dae93e0-048d-35a4-71ea-7c603184a130"/>
</subjectReference>
</PlanDefinition>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:8dae93e0-048d-35a4-71ea-7c603184a130"/>
<resource>
<SubstanceDefinition>
<!-- substance1 -->
<id value="8dae93e0-048d-35a4-71ea-7c603184a130"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="SubstanceDefinition_8dae93e0-048d-35a4-71ea-7c603184a130"> </a><p><b>Generated Narrative: SubstanceDefinition</b><a name="8dae93e0-048d-35a4-71ea-7c603184a130"> </a><a name="hc8dae93e0-048d-35a4-71ea-7c603184a130"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource SubstanceDefinition "8dae93e0-048d-35a4-71ea-7c603184a130" </p></div><p><b>manufacturer</b>: See on this page: Organization/3d399cbc-244e-9b5f-838b-b7daa0489330</p><h3>Names</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>Stelbatolol</td></tr></table></div>
</text>
<manufacturer>
<!-- Organization/substance-manufacturer -->
<reference
value="Organization/3d399cbc-244e-9b5f-838b-b7daa0489330"/>
</manufacturer>
<name>
<name value="Stelbatolol"/>
</name>
</SubstanceDefinition>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:3d399cbc-244e-9b5f-838b-b7daa0489330"/>
<resource>
<Organization>
<!-- substance-manufacturer -->
<id value="3d399cbc-244e-9b5f-838b-b7daa0489330"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Organization_3d399cbc-244e-9b5f-838b-b7daa0489330"> </a><p><b>Generated Narrative: Organization</b><a name="3d399cbc-244e-9b5f-838b-b7daa0489330"> </a><a name="hc3d399cbc-244e-9b5f-838b-b7daa0489330"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Organization "3d399cbc-244e-9b5f-838b-b7daa0489330" </p></div><p><b>identifier</b>: <code>urn:oid:2.16.840.1.113883.4.82</code>/3003040516</p><p><b>active</b>: true</p><p><b>type</b>: Drug Substance Manufacture <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-pharmaceutical-organization-type.html">Pharmaceutical Organization Type Codes</a>#drug-substance-manufacture)</span></p><p><b>name</b>: AAA Molybdenum Products, Inc.</p><h3>Contacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Address</b></td></tr><tr><td style="display: none">*</td><td>7233 W 116th Pl Ste C Broomfield Colorado 80020 USA </td></tr></table></div>
</text>
<identifier>
<!-- FDA establishment identifier -->
<system value="urn:oid:2.16.840.1.113883.4.82"/>
<value value="3003040516"/>
</identifier>
<active value="true"/>
<type>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/pharmaceutical-organization-type"/>
<code value="drug-substance-manufacture"/>
<display value="Drug Substance Manufacture"/>
</coding>
</type>
<name value="AAA Molybdenum Products, Inc."/>
<contact>
<address>
<line value="7233 W 116th Pl"/>
<line value="Ste C"/>
<city value="Broomfield"/>
<state value="Colorado"/>
<postalCode value="80020"/>
<country value="USA"/>
</address>
</contact>
</Organization>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:378fbe5f-5926-3a5c-4c64-5428df877b08"/>
<resource>
<Organization>
<!-- testing lab -->
<!-- 378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<id value="378fbe5f-5926-3a5c-4c64-5428df877b08"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Organization_378fbe5f-5926-3a5c-4c64-5428df877b08"> </a><p><b>Generated Narrative: Organization</b><a name="378fbe5f-5926-3a5c-4c64-5428df877b08"> </a><a name="hc378fbe5f-5926-3a5c-4c64-5428df877b08"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Organization "378fbe5f-5926-3a5c-4c64-5428df877b08" </p></div><p><b>identifier</b>: <code>urn:oid:2.16.840.1.113883.4.82</code>/3007270600</p><p><b>active</b>: true</p><p><b>type</b>: Analytical Testing - Release <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-pharmaceutical-organization-type.html">Pharmaceutical Organization Type Codes</a>#analytical-testing-release)</span></p><p><b>name</b>: Testing Lab</p></div>
</text>
<identifier>
<system value="urn:oid:2.16.840.1.113883.4.82"/>
<value value="3007270600"/>
</identifier>
<active value="true"/>
<type>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/pharmaceutical-organization-type"/>
<code value="analytical-testing-release"/>
<display value="Analytical Testing - Release"/>
</coding>
</type>
<name value="Testing Lab"/>
</Organization>
</resource>
</entry>
<!-- Diagnostic report doesn't carry much extra value but does collect all the observations -->
<entry>
<fullUrl value="urn:uuid:01a5777c-4b48-a0df-2963-02cd63339006"/>
<resource>
<DiagnosticReport>
<!-- ideally this wants a subject, but it can only be a Medication (batch) and we have multiple.
however the observations themselves do have subjects -->
<id value="batchAnalysisReport"/>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="DiagnosticReport_batchAnalysisReport"> </a><p><b>Generated Narrative: DiagnosticReport</b><a name="batchAnalysisReport"> </a><a name="hcbatchAnalysisReport"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource DiagnosticReport "batchAnalysisReport" </p></div><p><b>Triggered by</b>: See on this page: PlanDefinition/2038e4c7-22b8-4c56-2d28-6c077648763f</p><p><b>status</b>: final</p><p><b>code</b>: Batch Analysis Report <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-pharmaceutical-report-type.html">Pharmaceutical Report Type Codes</a>#Batch Analysis Report)</span></p><p><b>effective</b>: 2020-12</p><p><b>result</b>: </p><ul><li>See on this page: Observation/81f552f9-8458-3cf4-8379-eea5417a9de2</li><li>See on this page: Observation/50bf6f69-a3f5-678b-469b-c5df5cca4c86</li><li>See on this page: Observation/145fd3b7-3678-867f-4298-a6c781b86de3</li><li>See on this page: Observation/55c89944-60d1-4eea-a2c3-6c53e3622bc5</li><li>See on this page: Observation/adb51ab6-00a9-1078-69e5-d32c025a857c</li><li>See on this page: Observation/916a0ae2-9c43-72f0-a22a-c5f8ce902125</li><li>See on this page: Observation/6deb4306-1193-24ae-a565-f73225652bdd</li><li>See on this page: Observation/f6aabd2f-5902-57e7-6126-eccd9158a5b5</li><li>See on this page: Observation/32f598e4-a0e0-98dc-41dd-0f8397f953ad</li><li>See on this page: Observation/02d9e6be-833c-1c6d-a64a-baa3935c959d</li><li>See on this page: Observation/d3e572b7-14fd-744b-4123-58741d75571e</li><li>See on this page: Observation/fe6ca484-a755-9a0b-a074-b6ee0a907ff8</li><li>See on this page: Observation/da92c71f-a12a-1980-11a3-80e3d1852244</li><li>See on this page: Observation/8bf75da1-9221-66fe-6725-c64cb45a57e6</li><li>See on this page: Observation/31bfeff4-4a7d-3be5-878e-fb674d3d5487</li><li>See on this page: Observation/732237a9-4b3b-27cc-99ca-6b913e622a29</li><li>See on this page: Observation/52afbeb4-4958-a275-a0ca-d70b2b5240ec</li><li>See on this page: Observation/7fc395b1-59e4-78be-0512-cf92133c0fac</li><li>See on this page: Observation/9c98bd8a-7dda-2f01-0dbd-8c60b60e8572</li><li>See on this page: Observation/97b16ff8-8e0f-915a-9d65-7fab108f40c2</li><li>See on this page: Observation/0244eafe-3126-909b-7d8d-4253f45f525c</li><li>See on this page: Observation/10b80cbd-45d3-9be1-63b9-29f04b47376c</li><li>See on this page: Observation/84f015ac-9572-324f-8013-0b999cc95bbd</li><li>See on this page: Observation/987daeaa-4c2a-72b7-780f-4a9403163a3e</li><li>See on this page: Observation/02d9e6be-833c-1c6d-a64a-baa3935c959d</li><li>See on this page: Observation/d3e572b7-14fd-744b-4123-58741d75571e</li><li>See on this page: Observation/fe6ca484-a755-9a0b-a074-b6ee0a907ff8</li><li>See on this page: Observation/da92c71f-a12a-1980-11a3-80e3d1852244</li><li>See on this page: Observation/8bf75da1-9221-66fe-6725-c64cb45a57e6</li><li>See on this page: Observation/31bfeff4-4a7d-3be5-878e-fb674d3d5487</li><li>See on this page: Observation/732237a9-4b3b-27cc-99ca-6b913e622a29</li><li>See on this page: Observation/52afbeb4-4958-a275-a0ca-d70b2b5240ec</li><li>See on this page: Observation/7fc395b1-59e4-78be-0512-cf92133c0fac</li><li>See on this page: Observation/9c98bd8a-7dda-2f01-0dbd-8c60b60e8572</li><li>See on this page: Observation/97b16ff8-8e0f-915a-9d65-7fab108f40c2</li><li>See on this page: Observation/0244eafe-3126-909b-7d8d-4253f45f525c</li><li>See on this page: Observation/10b80cbd-45d3-9be1-63b9-29f04b47376c</li><li>See on this page: Observation/84f015ac-9572-324f-8013-0b999cc95bbd</li><li>See on this page: Observation/987daeaa-4c2a-72b7-780f-4a9403163a3e</li><li>See on this page: Observation/ff26533d-88a8-7f18-a275-42dc1373a388</li><li>See on this page: Observation/c99666d2-7962-9a71-58f6-7b2e5aa662f5</li><li>See on this page: Observation/c18e21d3-7113-4d08-4ff3-0c9718596f64</li><li>See on this page: Observation/66fdac46-2a6b-a66f-891b-8dcf67cc46c7</li><li>See on this page: Observation/8306cfc5-158f-1a53-a683-048b226060d9</li><li>See on this page: Observation/fc49ad55-07d1-997d-6695-bbff44746e75</li><li>See on this page: Observation/f8160692-a7a8-3fa6-9f35-e7df35f51ac0</li><li>See on this page: Observation/a531aee9-4c21-06af-352c-a3615b5d957e</li><li>See on this page: Observation/033ce81d-5f0d-7a3e-93d3-fc64e122a1fd</li><li>See on this page: Observation/ba8a182e-8571-6cbd-047b-612735d599d2</li><li>See on this page: Observation/0b5b94cc-7a1a-4ada-66c7-954ceb528d67</li><li>See on this page: Observation/6afaacee-11a6-58b2-47df-5f79722c66ac</li><li>See on this page: Observation/c2644a86-1684-286e-00e2-dcaf907a8970</li><li>See on this page: Observation/cb5f6872-6eeb-727a-7c33-f2c438581a1c</li><li>See on this page: Observation/7faaf980-7c10-7b9a-9572-1bacd485824e</li><li>See on this page: Observation/e4d2118a-8562-9eb1-2c14-4e145d2a95fc</li><li>See on this page: Observation/ec078717-9512-4db4-77c6-2c7e29d213a6</li><li>See on this page: Observation/05cfb495-2580-561a-688d-ce6ea24c8962</li><li>See on this page: Observation/d2a60ae5-96b4-3d13-38da-729c652347a3</li><li>See on this page: Observation/c3f51325-2f5f-194c-919b-2219ee1f5c45</li><li>See on this page: Observation/e9d89693-11b1-13ed-5cde-606fc1b8372c</li><li>See on this page: Observation/2659b000-96e2-1b8b-129b-0c00e1074b0f</li><li>See on this page: Observation/10b47328-36fa-343d-5699-5b32b30a6d33</li><li>See on this page: Observation/e6780766-317a-382f-92d2-79825f506cc5</li></ul><p><b>conclusion</b>: The samples have been assessed and the conclusion is...</p></div>
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<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_50bf6f69-a3f5-678b-469b-c5df5cca4c86"> </a><p><b>Generated Narrative: Observation</b><a name="50bf6f69-a3f5-678b-469b-c5df5cca4c86"> </a><a name="hc50bf6f69-a3f5-678b-469b-c5df5cca4c86"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "50bf6f69-a3f5-678b-469b-c5df5cca4c86" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/13033a89-927a-10e0-503e-5f901bdca30f</p><p><b>status</b>: final</p><p><b>code</b>: Description <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#DESC)</span></p><p><b>subject</b>: See on this page: Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: Pass <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p></div>
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<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="DESC"/>
<display value="Description"/>
</coding>
<text value="Description"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-3 -->
<reference value="Substance/ef17cff1-6586-a4a4-9168-2602140548d7"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueCodeableConcept>
<text value="Pass"/>
</valueCodeableConcept>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:55c89944-60d1-4eea-a2c3-6c53e3622bc5"/>
<resource>
<Observation>
<!-- observationIdentification -->
<id value="55c89944-60d1-4eea-a2c3-6c53e3622bc5"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_55c89944-60d1-4eea-a2c3-6c53e3622bc5"> </a><p><b>Generated Narrative: Observation</b><a name="55c89944-60d1-4eea-a2c3-6c53e3622bc5"> </a><a name="hc55c89944-60d1-4eea-a2c3-6c53e3622bc5"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "55c89944-60d1-4eea-a2c3-6c53e3622bc5" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/8395ae1d-5064-0ab7-a297-6b20285b2230</p><p><b>status</b>: final</p><p><b>code</b>: Identification <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IDT)</span></p><p><b>subject</b>: See on this page: Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: Conforms <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Identification -->
<reference
value="ObservationDefinition/8395ae1d-5064-0ab7-a297-6b20285b2230"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="IDT"/>
<display value="Identification"/>
</coding>
<text value="Identification"/>
</code>
<subject>
<!-- Substance/substance-drug-pq-ex1 -->
<reference value="Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueCodeableConcept>
<text value="Conforms"/>
</valueCodeableConcept>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:adb51ab6-00a9-1078-69e5-d32c025a857c"/>
<resource>
<Observation>
<!-- observationIdentification2 -->
<id value="adb51ab6-00a9-1078-69e5-d32c025a857c"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_adb51ab6-00a9-1078-69e5-d32c025a857c"> </a><p><b>Generated Narrative: Observation</b><a name="adb51ab6-00a9-1078-69e5-d32c025a857c"> </a><a name="hcadb51ab6-00a9-1078-69e5-d32c025a857c"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "adb51ab6-00a9-1078-69e5-d32c025a857c" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/8395ae1d-5064-0ab7-a297-6b20285b2230</p><p><b>status</b>: final</p><p><b>code</b>: Identification <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IDT)</span></p><p><b>subject</b>: See on this page: Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: Does not conform <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Identification -->
<reference
value="ObservationDefinition/8395ae1d-5064-0ab7-a297-6b20285b2230"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="IDT"/>
<display value="Identification"/>
</coding>
<text value="Identification"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-2 -->
<reference value="Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueCodeableConcept>
<text value="Does not conform"/>
</valueCodeableConcept>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:916a0ae2-9c43-72f0-a22a-c5f8ce902125"/>
<resource>
<Observation>
<!-- observationIdentification3 -->
<id value="916a0ae2-9c43-72f0-a22a-c5f8ce902125"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_916a0ae2-9c43-72f0-a22a-c5f8ce902125"> </a><p><b>Generated Narrative: Observation</b><a name="916a0ae2-9c43-72f0-a22a-c5f8ce902125"> </a><a name="hc916a0ae2-9c43-72f0-a22a-c5f8ce902125"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "916a0ae2-9c43-72f0-a22a-c5f8ce902125" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/8395ae1d-5064-0ab7-a297-6b20285b2230</p><p><b>status</b>: final</p><p><b>code</b>: Identification <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IDT)</span></p><p><b>subject</b>: See on this page: Substance/ef17cff1-6586-a4a4-9168-2602140548d7</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: Conforms <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Identification -->
<reference
value="ObservationDefinition/8395ae1d-5064-0ab7-a297-6b20285b2230"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="IDT"/>
<display value="Identification"/>
</coding>
<text value="Identification"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-3 -->
<reference value="Substance/ef17cff1-6586-a4a4-9168-2602140548d7"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueCodeableConcept>
<text value="Conforms"/>
</valueCodeableConcept>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:6deb4306-1193-24ae-a565-f73225652bdd"/>
<resource>
<Observation>
<!-- observationAssay -->
<id value="6deb4306-1193-24ae-a565-f73225652bdd"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_6deb4306-1193-24ae-a565-f73225652bdd"> </a><p><b>Generated Narrative: Observation</b><a name="6deb4306-1193-24ae-a565-f73225652bdd"> </a><a name="hc6deb4306-1193-24ae-a565-f73225652bdd"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "6deb4306-1193-24ae-a565-f73225652bdd" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/2117208e-4185-9091-1f86-cce37b121838</p><p><b>status</b>: final</p><p><b>code</b>: Assay <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#ASSAY)</span></p><p><b>subject</b>: See on this page: Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 94 %<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><p><b>note</b>: CAT1, CAT2 and CAT3 met the clinical specification in place at time of testing; clinical specification release limit for Assay was 93% w/w; clinical specification release limit for Enantiomeric Purity was NLT 91.0%</p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Assay -->
<reference
value="ObservationDefinition/2117208e-4185-9091-1f86-cce37b121838"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="ASSAY"/>
<display value="Assay"/>
</coding>
<text value="Assay"/>
</code>
<subject>
<!-- Substance/substance-drug-pq-ex1 -->
<reference value="Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="94"/>
<unit value="%"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<note>
<text
value="CAT1, CAT2 and CAT3 met the clinical specification in place at time of testing; clinical specification release limit for Assay was 93% w/w; clinical specification release limit for Enantiomeric Purity was NLT 91.0%"/>
</note>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:f6aabd2f-5902-57e7-6126-eccd9158a5b5"/>
<resource>
<Observation>
<!-- observationAssay2 -->
<id value="f6aabd2f-5902-57e7-6126-eccd9158a5b5"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_f6aabd2f-5902-57e7-6126-eccd9158a5b5"> </a><p><b>Generated Narrative: Observation</b><a name="f6aabd2f-5902-57e7-6126-eccd9158a5b5"> </a><a name="hcf6aabd2f-5902-57e7-6126-eccd9158a5b5"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "f6aabd2f-5902-57e7-6126-eccd9158a5b5" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/2117208e-4185-9091-1f86-cce37b121838</p><p><b>status</b>: final</p><p><b>code</b>: Assay <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#ASSAY)</span></p><p><b>subject</b>: See on this page: Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 95 %<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><p><b>note</b>: CAT1, CAT2 and CAT3 met the clinical specification in place at time of testing; clinical specification release limit for Assay was 93% w/w; clinical specification release limit for Enantiomeric Purity was NLT 91.0%</p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Assay -->
<reference
value="ObservationDefinition/2117208e-4185-9091-1f86-cce37b121838"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="ASSAY"/>
<display value="Assay"/>
</coding>
<text value="Assay"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-2 -->
<reference value="Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="95"/>
<unit value="%"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<note>
<text
value="CAT1, CAT2 and CAT3 met the clinical specification in place at time of testing; clinical specification release limit for Assay was 93% w/w; clinical specification release limit for Enantiomeric Purity was NLT 91.0%"/>
</note>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:32f598e4-a0e0-98dc-41dd-0f8397f953ad"/>
<resource>
<Observation>
<!-- observationAssay3 -->
<id value="32f598e4-a0e0-98dc-41dd-0f8397f953ad"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_32f598e4-a0e0-98dc-41dd-0f8397f953ad"> </a><p><b>Generated Narrative: Observation</b><a name="32f598e4-a0e0-98dc-41dd-0f8397f953ad"> </a><a name="hc32f598e4-a0e0-98dc-41dd-0f8397f953ad"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "32f598e4-a0e0-98dc-41dd-0f8397f953ad" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/2117208e-4185-9091-1f86-cce37b121838</p><p><b>status</b>: final</p><p><b>code</b>: Assay <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#ASSAY)</span></p><p><b>subject</b>: See on this page: Substance/ef17cff1-6586-a4a4-9168-2602140548d7</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 96 %<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><p><b>note</b>: CAT1, CAT2 and CAT3 met the clinical specification in place at time of testing; clinical specification release limit for Assay was 93% w/w; clinical specification release limit for Enantiomeric Purity was NLT 91.0%</p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Assay -->
<reference
value="ObservationDefinition/2117208e-4185-9091-1f86-cce37b121838"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="ASSAY"/>
<display value="Assay"/>
</coding>
<text value="Assay"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-3 -->
<reference value="Substance/ef17cff1-6586-a4a4-9168-2602140548d7"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="96"/>
<unit value="%"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<note>
<text
value="CAT1, CAT2 and CAT3 met the clinical specification in place at time of testing; clinical specification release limit for Assay was 93% w/w; clinical specification release limit for Enantiomeric Purity was NLT 91.0%"/>
</note>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:02d9e6be-833c-1c6d-a64a-baa3935c959d"/>
<resource>
<Observation>
<!-- observationDegradation-imp1 -->
<id value="02d9e6be-833c-1c6d-a64a-baa3935c959d"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_02d9e6be-833c-1c6d-a64a-baa3935c959d"> </a><p><b>Generated Narrative: Observation</b><a name="02d9e6be-833c-1c6d-a64a-baa3935c959d"> </a><a name="hc02d9e6be-833c-1c6d-a64a-baa3935c959d"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "02d9e6be-833c-1c6d-a64a-baa3935c959d" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8</p><p><b>status</b>: final</p><p><b>code</b>: Impurities <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Impurities)</span></p><p><b>subject</b>: See on this page: Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.5 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Impurity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IMP)</span></td><td>Impurity 1 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Impurities -->
<reference
value="ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="Impurities"/>
<display value="Impurities"/>
</coding>
<text value="Impurities"/>
</code>
<subject>
<!-- Substance/substance-drug-pq-ex1 -->
<reference value="Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.5"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="IMP"/>
<display value="Impurity"/>
</coding>
</code>
<valueCodeableConcept>
<text value="Impurity 1"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:d3e572b7-14fd-744b-4123-58741d75571e"/>
<resource>
<Observation>
<!-- observationDegradation-imp1-2 -->
<id value="d3e572b7-14fd-744b-4123-58741d75571e"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_d3e572b7-14fd-744b-4123-58741d75571e"> </a><p><b>Generated Narrative: Observation</b><a name="d3e572b7-14fd-744b-4123-58741d75571e"> </a><a name="hcd3e572b7-14fd-744b-4123-58741d75571e"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "d3e572b7-14fd-744b-4123-58741d75571e" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8</p><p><b>status</b>: final</p><p><b>code</b>: Impurities <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Impurities)</span></p><p><b>subject</b>: See on this page: Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.4 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Impurity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IMP)</span></td><td>Impurity 1 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Impurities -->
<reference
value="ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="Impurities"/>
<display value="Impurities"/>
</coding>
<text value="Impurities"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-2 -->
<reference value="Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.4"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="IMP"/>
<display value="Impurity"/>
</coding>
</code>
<valueCodeableConcept>
<text value="Impurity 1"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:fe6ca484-a755-9a0b-a074-b6ee0a907ff8"/>
<resource>
<Observation>
<!-- observationDegradation-imp1-3 -->
<id value="fe6ca484-a755-9a0b-a074-b6ee0a907ff8"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_fe6ca484-a755-9a0b-a074-b6ee0a907ff8"> </a><p><b>Generated Narrative: Observation</b><a name="fe6ca484-a755-9a0b-a074-b6ee0a907ff8"> </a><a name="hcfe6ca484-a755-9a0b-a074-b6ee0a907ff8"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "fe6ca484-a755-9a0b-a074-b6ee0a907ff8" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8</p><p><b>status</b>: final</p><p><b>code</b>: Impurities <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Impurities)</span></p><p><b>subject</b>: See on this page: Substance/ef17cff1-6586-a4a4-9168-2602140548d7</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.2 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Impurity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IMP)</span></td><td>Impurity 1 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Impurities -->
<reference
value="ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="Impurities"/>
<display value="Impurities"/>
</coding>
<text value="Impurities"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-3 -->
<reference value="Substance/ef17cff1-6586-a4a4-9168-2602140548d7"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.2"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="IMP"/>
<display value="Impurity"/>
</coding>
</code>
<valueCodeableConcept>
<text value="Impurity 1"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:da92c71f-a12a-1980-11a3-80e3d1852244"/>
<resource>
<Observation>
<!-- observationDegradation-imp2 -->
<id value="da92c71f-a12a-1980-11a3-80e3d1852244"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_da92c71f-a12a-1980-11a3-80e3d1852244"> </a><p><b>Generated Narrative: Observation</b><a name="da92c71f-a12a-1980-11a3-80e3d1852244"> </a><a name="hcda92c71f-a12a-1980-11a3-80e3d1852244"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "da92c71f-a12a-1980-11a3-80e3d1852244" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8</p><p><b>status</b>: final</p><p><b>code</b>: Impurities <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Impurities)</span></p><p><b>subject</b>: See on this page: Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.5 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Impurity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IMP)</span></td><td>Impurity 2 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Impurities -->
<reference
value="ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="Impurities"/>
<display value="Impurities"/>
</coding>
<text value="Impurities"/>
</code>
<subject>
<!-- Substance/substance-drug-pq-ex1 -->
<reference value="Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.5"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="IMP"/>
<display value="Impurity"/>
</coding>
</code>
<valueCodeableConcept>
<text value="Impurity 2"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:8bf75da1-9221-66fe-6725-c64cb45a57e6"/>
<resource>
<Observation>
<!-- observationDegradation-imp2-2 -->
<id value="8bf75da1-9221-66fe-6725-c64cb45a57e6"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_8bf75da1-9221-66fe-6725-c64cb45a57e6"> </a><p><b>Generated Narrative: Observation</b><a name="8bf75da1-9221-66fe-6725-c64cb45a57e6"> </a><a name="hc8bf75da1-9221-66fe-6725-c64cb45a57e6"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "8bf75da1-9221-66fe-6725-c64cb45a57e6" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8</p><p><b>status</b>: final</p><p><b>code</b>: Impurities <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Impurities)</span></p><p><b>subject</b>: See on this page: Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.4 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Impurity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IMP)</span></td><td>Impurity 2 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Impurities -->
<reference
value="ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="Impurities"/>
<display value="Impurities"/>
</coding>
<text value="Impurities"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-2 -->
<reference value="Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.4"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="IMP"/>
<display value="Impurity"/>
</coding>
</code>
<valueCodeableConcept>
<text value="Impurity 2"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:31bfeff4-4a7d-3be5-878e-fb674d3d5487"/>
<resource>
<Observation>
<!-- observationDegradation-imp2-3 -->
<id value="31bfeff4-4a7d-3be5-878e-fb674d3d5487"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_31bfeff4-4a7d-3be5-878e-fb674d3d5487"> </a><p><b>Generated Narrative: Observation</b><a name="31bfeff4-4a7d-3be5-878e-fb674d3d5487"> </a><a name="hc31bfeff4-4a7d-3be5-878e-fb674d3d5487"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "31bfeff4-4a7d-3be5-878e-fb674d3d5487" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8</p><p><b>status</b>: final</p><p><b>code</b>: Impurities <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Impurities)</span></p><p><b>subject</b>: See on this page: Substance/ef17cff1-6586-a4a4-9168-2602140548d7</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.2 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Impurity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IMP)</span></td><td>Impurity 2 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Impurities -->
<reference
value="ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="Impurities"/>
<display value="Impurities"/>
</coding>
<text value="Impurities"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-3 -->
<reference value="Substance/ef17cff1-6586-a4a4-9168-2602140548d7"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.2"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="IMP"/>
<display value="Impurity"/>
</coding>
</code>
<valueCodeableConcept>
<text value="Impurity 2"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:732237a9-4b3b-27cc-99ca-6b913e622a29"/>
<resource>
<Observation>
<!-- observationDegradation-imp3 -->
<id value="732237a9-4b3b-27cc-99ca-6b913e622a29"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_732237a9-4b3b-27cc-99ca-6b913e622a29"> </a><p><b>Generated Narrative: Observation</b><a name="732237a9-4b3b-27cc-99ca-6b913e622a29"> </a><a name="hc732237a9-4b3b-27cc-99ca-6b913e622a29"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "732237a9-4b3b-27cc-99ca-6b913e622a29" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8</p><p><b>status</b>: final</p><p><b>code</b>: Impurities <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Impurities)</span></p><p><b>subject</b>: See on this page: Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.1 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Impurity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IMP)</span></td><td>Impurity 3 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Impurities -->
<reference
value="ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="Impurities"/>
<display value="Impurities"/>
</coding>
<text value="Impurities"/>
</code>
<subject>
<!-- Substance/substance-drug-pq-ex1 -->
<reference value="Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.1"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="IMP"/>
<display value="Impurity"/>
</coding>
</code>
<valueCodeableConcept>
<text value="Impurity 3"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:52afbeb4-4958-a275-a0ca-d70b2b5240ec"/>
<resource>
<Observation>
<!-- observationDegradation-imp3-2 -->
<id value="52afbeb4-4958-a275-a0ca-d70b2b5240ec"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_52afbeb4-4958-a275-a0ca-d70b2b5240ec"> </a><p><b>Generated Narrative: Observation</b><a name="52afbeb4-4958-a275-a0ca-d70b2b5240ec"> </a><a name="hc52afbeb4-4958-a275-a0ca-d70b2b5240ec"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "52afbeb4-4958-a275-a0ca-d70b2b5240ec" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8</p><p><b>status</b>: final</p><p><b>code</b>: Impurities <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Impurities)</span></p><p><b>subject</b>: See on this page: Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.1 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Impurity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IMP)</span></td><td>Impurity 3 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Impurities -->
<reference
value="ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="Impurities"/>
<display value="Impurities"/>
</coding>
<text value="Impurities"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-2 -->
<reference value="Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.1"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="IMP"/>
<display value="Impurity"/>
</coding>
</code>
<valueCodeableConcept>
<text value="Impurity 3"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:7fc395b1-59e4-78be-0512-cf92133c0fac"/>
<resource>
<Observation>
<!-- observationDegradation-imp3-3 -->
<id value="7fc395b1-59e4-78be-0512-cf92133c0fac"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_7fc395b1-59e4-78be-0512-cf92133c0fac"> </a><p><b>Generated Narrative: Observation</b><a name="7fc395b1-59e4-78be-0512-cf92133c0fac"> </a><a name="hc7fc395b1-59e4-78be-0512-cf92133c0fac"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "7fc395b1-59e4-78be-0512-cf92133c0fac" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8</p><p><b>status</b>: final</p><p><b>code</b>: Impurities <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Impurities)</span></p><p><b>subject</b>: See on this page: Substance/ef17cff1-6586-a4a4-9168-2602140548d7</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.1 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Impurity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IMP)</span></td><td>Impurity 3 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Impurities -->
<reference
value="ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="Impurities"/>
<display value="Impurities"/>
</coding>
<text value="Impurities"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-3 -->
<reference value="Substance/ef17cff1-6586-a4a4-9168-2602140548d7"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.1"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="IMP"/>
<display value="Impurity"/>
</coding>
</code>
<valueCodeableConcept>
<text value="Impurity 3"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:9c98bd8a-7dda-2f01-0dbd-8c60b60e8572"/>
<resource>
<Observation>
<!-- observationDegradation-imp-unspecified -->
<id value="9c98bd8a-7dda-2f01-0dbd-8c60b60e8572"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_9c98bd8a-7dda-2f01-0dbd-8c60b60e8572"> </a><p><b>Generated Narrative: Observation</b><a name="9c98bd8a-7dda-2f01-0dbd-8c60b60e8572"> </a><a name="hc9c98bd8a-7dda-2f01-0dbd-8c60b60e8572"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "9c98bd8a-7dda-2f01-0dbd-8c60b60e8572" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8</p><p><b>status</b>: final</p><p><b>code</b>: Impurities <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Impurities)</span></p><p><b>subject</b>: See on this page: Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.1 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Impurity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IMP)</span></td><td>Any individual unspecified impurity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Impurities -->
<reference
value="ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="Impurities"/>
<display value="Impurities"/>
</coding>
<text value="Impurities"/>
</code>
<subject>
<!-- Substance/substance-drug-pq-ex1 -->
<reference value="Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.1"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="IMP"/>
<display value="Impurity"/>
</coding>
</code>
<valueCodeableConcept>
<text value="Any individual unspecified impurity"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:97b16ff8-8e0f-915a-9d65-7fab108f40c2"/>
<resource>
<Observation>
<!-- observationDegradation-imp-unspecified-2 -->
<id value="97b16ff8-8e0f-915a-9d65-7fab108f40c2"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_97b16ff8-8e0f-915a-9d65-7fab108f40c2"> </a><p><b>Generated Narrative: Observation</b><a name="97b16ff8-8e0f-915a-9d65-7fab108f40c2"> </a><a name="hc97b16ff8-8e0f-915a-9d65-7fab108f40c2"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "97b16ff8-8e0f-915a-9d65-7fab108f40c2" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8</p><p><b>status</b>: final</p><p><b>code</b>: Impurities <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Impurities)</span></p><p><b>subject</b>: See on this page: Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.1 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Impurity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IMP)</span></td><td>Any individual unspecified impurity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Impurities -->
<reference
value="ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="Impurities"/>
<display value="Impurities"/>
</coding>
<text value="Impurities"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-2 -->
<reference value="Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.1"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="IMP"/>
<display value="Impurity"/>
</coding>
</code>
<valueCodeableConcept>
<text value="Any individual unspecified impurity"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:0244eafe-3126-909b-7d8d-4253f45f525c"/>
<resource>
<Observation>
<!-- observationDegradation-imp-unspecified-3 -->
<id value="0244eafe-3126-909b-7d8d-4253f45f525c"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_0244eafe-3126-909b-7d8d-4253f45f525c"> </a><p><b>Generated Narrative: Observation</b><a name="0244eafe-3126-909b-7d8d-4253f45f525c"> </a><a name="hc0244eafe-3126-909b-7d8d-4253f45f525c"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "0244eafe-3126-909b-7d8d-4253f45f525c" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8</p><p><b>status</b>: final</p><p><b>code</b>: Impurities <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Impurities)</span></p><p><b>subject</b>: See on this page: Substance/ef17cff1-6586-a4a4-9168-2602140548d7</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.1 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Impurity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IMP)</span></td><td>Any individual unspecified impurity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Impurities -->
<reference
value="ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="Impurities"/>
<display value="Impurities"/>
</coding>
<text value="Impurities"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-3 -->
<reference value="Substance/ef17cff1-6586-a4a4-9168-2602140548d7"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.1"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="IMP"/>
<display value="Impurity"/>
</coding>
</code>
<valueCodeableConcept>
<!-- could have the code of an imw substance, or could have an extension to point to it as a resource -->
<text value="Any individual unspecified impurity"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:10b80cbd-45d3-9be1-63b9-29f04b47376c"/>
<resource>
<Observation>
<!-- observationDegradation-imp-total -->
<id value="10b80cbd-45d3-9be1-63b9-29f04b47376c"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_10b80cbd-45d3-9be1-63b9-29f04b47376c"> </a><p><b>Generated Narrative: Observation</b><a name="10b80cbd-45d3-9be1-63b9-29f04b47376c"> </a><a name="hc10b80cbd-45d3-9be1-63b9-29f04b47376c"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "10b80cbd-45d3-9be1-63b9-29f04b47376c" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8</p><p><b>status</b>: final</p><p><b>code</b>: Impurities <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Impurities)</span></p><p><b>subject</b>: See on this page: Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.02 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Impurity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IMP)</span></td><td>Total impurities <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Impurities -->
<reference
value="ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="Impurities"/>
<display value="Impurities"/>
</coding>
<text value="Impurities"/>
</code>
<subject>
<!-- Substance/substance-drug-pq-ex1 -->
<reference value="Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.02"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="IMP"/>
<display value="Impurity"/>
</coding>
</code>
<valueCodeableConcept>
<text value="Total impurities"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:84f015ac-9572-324f-8013-0b999cc95bbd"/>
<resource>
<Observation>
<!-- observationDegradation-imp-total-2 -->
<id value="84f015ac-9572-324f-8013-0b999cc95bbd"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_84f015ac-9572-324f-8013-0b999cc95bbd"> </a><p><b>Generated Narrative: Observation</b><a name="84f015ac-9572-324f-8013-0b999cc95bbd"> </a><a name="hc84f015ac-9572-324f-8013-0b999cc95bbd"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "84f015ac-9572-324f-8013-0b999cc95bbd" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8</p><p><b>status</b>: final</p><p><b>code</b>: Impurities <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Impurities)</span></p><p><b>subject</b>: See on this page: Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.02 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Impurity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IMP)</span></td><td>Total impurities <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Impurities -->
<reference
value="ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="Impurities"/>
<display value="Impurities"/>
</coding>
<text value="Impurities"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-2 -->
<reference value="Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.02"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="IMP"/>
<display value="Impurity"/>
</coding>
</code>
<valueCodeableConcept>
<text value="Total impurities"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:987daeaa-4c2a-72b7-780f-4a9403163a3e"/>
<resource>
<Observation>
<!-- observationDegradation-imp-total-3 -->
<id value="987daeaa-4c2a-72b7-780f-4a9403163a3e"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_987daeaa-4c2a-72b7-780f-4a9403163a3e"> </a><p><b>Generated Narrative: Observation</b><a name="987daeaa-4c2a-72b7-780f-4a9403163a3e"> </a><a name="hc987daeaa-4c2a-72b7-780f-4a9403163a3e"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "987daeaa-4c2a-72b7-780f-4a9403163a3e" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8</p><p><b>status</b>: final</p><p><b>code</b>: Impurities <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#Impurities)</span></p><p><b>subject</b>: See on this page: Substance/ef17cff1-6586-a4a4-9168-2602140548d7</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.02 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Impurity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IMP)</span></td><td>Total impurities <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Impurities -->
<reference
value="ObservationDefinition/d04e0f2a-6ee7-6c2e-1db8-7df394c927b8"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="Impurities"/>
<display value="Impurities"/>
</coding>
<text value="Impurities"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-3 -->
<reference value="Substance/ef17cff1-6586-a4a4-9168-2602140548d7"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.02"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="IMP"/>
<display value="Impurity"/>
</coding>
</code>
<valueCodeableConcept>
<!-- could have the code of an imr substance, or could have an extension to point to it as a resource -->
<text value="Total impurities"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:ff26533d-88a8-7f18-a275-42dc1373a388"/>
<resource>
<Observation>
<!-- observationMutagenic -->
<id value="ff26533d-88a8-7f18-a275-42dc1373a388"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_ff26533d-88a8-7f18-a275-42dc1373a388"> </a><p><b>Generated Narrative: Observation</b><a name="ff26533d-88a8-7f18-a275-42dc1373a388"> </a><a name="hcff26533d-88a8-7f18-a275-42dc1373a388"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "ff26533d-88a8-7f18-a275-42dc1373a388" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/0634020c-8729-99fc-7637-89799d7c445b</p><p><b>status</b>: final</p><p><b>code</b>: Mutagenic impurities <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#MUT)</span></p><p><b>subject</b>: See on this page: Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 20 ppm<span style="background: LightGoldenRodYellow"> (Details: UCUM code [ppm] = '[ppm]')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Impurity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IMP)</span></td><td>Impurity - Mutagenic <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Mutagenic -->
<reference
value="ObservationDefinition/0634020c-8729-99fc-7637-89799d7c445b"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="MUT"/>
<display value="Mutagenic impurities"/>
</coding>
</code>
<subject>
<!-- Substance/substance-drug-pq-ex1 -->
<reference value="Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="20"/>
<unit value="ppm"/>
<system value="http://unitsofmeasure.org"/>
<code value="[ppm]"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="IMP"/>
<display value="Impurity"/>
</coding>
</code>
<valueCodeableConcept>
<text value="Impurity - Mutagenic"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:c99666d2-7962-9a71-58f6-7b2e5aa662f5"/>
<resource>
<Observation>
<!-- observationMutagenic2 -->
<id value="c99666d2-7962-9a71-58f6-7b2e5aa662f5"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_c99666d2-7962-9a71-58f6-7b2e5aa662f5"> </a><p><b>Generated Narrative: Observation</b><a name="c99666d2-7962-9a71-58f6-7b2e5aa662f5"> </a><a name="hcc99666d2-7962-9a71-58f6-7b2e5aa662f5"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "c99666d2-7962-9a71-58f6-7b2e5aa662f5" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/0634020c-8729-99fc-7637-89799d7c445b</p><p><b>status</b>: final</p><p><b>code</b>: Mutagenic <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#MUT "Mutagenic impurities")</span></p><p><b>subject</b>: See on this page: Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 22 %<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Mutagenic -->
<reference
value="ObservationDefinition/0634020c-8729-99fc-7637-89799d7c445b"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="MUT"/>
<display value="Mutagenic impurities"/>
</coding>
<text value="Mutagenic"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-2 -->
<reference value="Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="22"/>
<unit value="%"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:c18e21d3-7113-4d08-4ff3-0c9718596f64"/>
<resource>
<Observation>
<!-- observationMutagenic3 -->
<id value="c18e21d3-7113-4d08-4ff3-0c9718596f64"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_c18e21d3-7113-4d08-4ff3-0c9718596f64"> </a><p><b>Generated Narrative: Observation</b><a name="c18e21d3-7113-4d08-4ff3-0c9718596f64"> </a><a name="hcc18e21d3-7113-4d08-4ff3-0c9718596f64"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "c18e21d3-7113-4d08-4ff3-0c9718596f64" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/0634020c-8729-99fc-7637-89799d7c445b</p><p><b>status</b>: final</p><p><b>code</b>: Mutagenic <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#MUT "Mutagenic impurities")</span></p><p><b>subject</b>: See on this page: Substance/ef17cff1-6586-a4a4-9168-2602140548d7</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 18 %<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Mutagenic -->
<reference
value="ObservationDefinition/0634020c-8729-99fc-7637-89799d7c445b"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="MUT"/>
<display value="Mutagenic impurities"/>
</coding>
<text value="Mutagenic"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-3 -->
<reference value="Substance/ef17cff1-6586-a4a4-9168-2602140548d7"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="18"/>
<unit value="%"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:66fdac46-2a6b-a66f-891b-8dcf67cc46c7"/>
<resource>
<Observation>
<!-- observationEnantiomericPurity -->
<id value="66fdac46-2a6b-a66f-891b-8dcf67cc46c7"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_66fdac46-2a6b-a66f-891b-8dcf67cc46c7"> </a><p><b>Generated Narrative: Observation</b><a name="66fdac46-2a6b-a66f-891b-8dcf67cc46c7"> </a><a name="hc66fdac46-2a6b-a66f-891b-8dcf67cc46c7"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "66fdac46-2a6b-a66f-891b-8dcf67cc46c7" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/4e67725b-20c8-158e-9d53-1810bfa58d87</p><p><b>status</b>: final</p><p><b>code</b>: Enantiomeric purity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#enantiomeric-purity)</span></p><p><b>subject</b>: See on this page: Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 91.5 %<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><p><b>note</b>: CAT1, CAT2 and CAT3 met the clinical specification in place at time of testing; clinical specification release limit for Assay was 93% w/w; clinical specification release limit for Enantiomeric Purity was NLT 91.0%</p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Enantiomeric -->
<reference
value="ObservationDefinition/4e67725b-20c8-158e-9d53-1810bfa58d87"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="enantiomeric-purity"/>
<display value="Enantiomeric purity"/>
</coding>
<text value="Enantiomeric purity"/>
</code>
<subject>
<!-- Substance/substance-drug-pq-ex1 -->
<reference value="Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="91.5"/>
<unit value="%"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<note>
<text
value="CAT1, CAT2 and CAT3 met the clinical specification in place at time of testing; clinical specification release limit for Assay was 93% w/w; clinical specification release limit for Enantiomeric Purity was NLT 91.0%"/>
</note>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:8306cfc5-158f-1a53-a683-048b226060d9"/>
<resource>
<Observation>
<!-- observationEnantiomericPurity2 -->
<id value="8306cfc5-158f-1a53-a683-048b226060d9"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_8306cfc5-158f-1a53-a683-048b226060d9"> </a><p><b>Generated Narrative: Observation</b><a name="8306cfc5-158f-1a53-a683-048b226060d9"> </a><a name="hc8306cfc5-158f-1a53-a683-048b226060d9"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "8306cfc5-158f-1a53-a683-048b226060d9" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/4e67725b-20c8-158e-9d53-1810bfa58d87</p><p><b>status</b>: final</p><p><b>code</b>: Enantiomeric purity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#enantiomeric-purity)</span></p><p><b>subject</b>: See on this page: Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 91.5 %<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><p><b>note</b>: CAT1, CAT2 and CAT3 met the clinical specification in place at time of testing; clinical specification release limit for Assay was 93% w/w; clinical specification release limit for Enantiomeric Purity was NLT 91.0%</p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Enantiomeric -->
<reference
value="ObservationDefinition/4e67725b-20c8-158e-9d53-1810bfa58d87"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="enantiomeric-purity"/>
<display value="Enantiomeric purity"/>
</coding>
<text value="Enantiomeric purity"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-2 -->
<reference value="Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="91.5"/>
<unit value="%"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<note>
<text
value="CAT1, CAT2 and CAT3 met the clinical specification in place at time of testing; clinical specification release limit for Assay was 93% w/w; clinical specification release limit for Enantiomeric Purity was NLT 91.0%"/>
</note>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:fc49ad55-07d1-997d-6695-bbff44746e75"/>
<resource>
<Observation>
<!-- observationEnantiomericPurity3 -->
<id value="fc49ad55-07d1-997d-6695-bbff44746e75"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_fc49ad55-07d1-997d-6695-bbff44746e75"> </a><p><b>Generated Narrative: Observation</b><a name="fc49ad55-07d1-997d-6695-bbff44746e75"> </a><a name="hcfc49ad55-07d1-997d-6695-bbff44746e75"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "fc49ad55-07d1-997d-6695-bbff44746e75" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/4e67725b-20c8-158e-9d53-1810bfa58d87</p><p><b>status</b>: final</p><p><b>code</b>: Enantiomeric purity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#enantiomeric-purity)</span></p><p><b>subject</b>: See on this page: Substance/ef17cff1-6586-a4a4-9168-2602140548d7</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 91.5 %<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><p><b>note</b>: Batch 3 did not originally meet specification criteria, and was subject to reprocessing and repurification. The updated result is presented in this table. The lot was not distributed for human use.</p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Enantiomeric -->
<reference
value="ObservationDefinition/4e67725b-20c8-158e-9d53-1810bfa58d87"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="enantiomeric-purity"/>
<display value="Enantiomeric purity"/>
</coding>
<text value="Enantiomeric purity"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-3 -->
<reference value="Substance/ef17cff1-6586-a4a4-9168-2602140548d7"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="91.5"/>
<unit value="%"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<note>
<text
value="Batch 3 did not originally meet specification criteria, and was subject to reprocessing and repurification. The updated result is presented in this table. The lot was not distributed for human use."/>
</note>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:f8160692-a7a8-3fa6-9f35-e7df35f51ac0"/>
<resource>
<Observation>
<!-- observationSolvents-sol1 -->
<id value="f8160692-a7a8-3fa6-9f35-e7df35f51ac0"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_f8160692-a7a8-3fa6-9f35-e7df35f51ac0"> </a><p><b>Generated Narrative: Observation</b><a name="f8160692-a7a8-3fa6-9f35-e7df35f51ac0"> </a><a name="hcf8160692-a7a8-3fa6-9f35-e7df35f51ac0"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "f8160692-a7a8-3fa6-9f35-e7df35f51ac0" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/2daba8ca-211f-4f4b-4028-16c30fe22ee8</p><p><b>status</b>: final</p><p><b>code</b>: Residual solvents <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#SOL)</span></p><p><b>subject</b>: See on this page: Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.1 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Solvent <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#SOLV)</span></td><td>Solvent 1 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Solvents -->
<reference
value="ObservationDefinition/2daba8ca-211f-4f4b-4028-16c30fe22ee8"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="SOL"/>
<display value="Residual solvents"/>
</coding>
</code>
<subject>
<!-- Substance/substance-drug-pq-ex1 -->
<reference value="Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.1"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="SOLV"/>
<display value="Solvent"/>
</coding>
</code>
<valueCodeableConcept>
<text value="Solvent 1"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:a531aee9-4c21-06af-352c-a3615b5d957e"/>
<resource>
<Observation>
<!-- observationSolvents-sol1-2 -->
<id value="a531aee9-4c21-06af-352c-a3615b5d957e"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_a531aee9-4c21-06af-352c-a3615b5d957e"> </a><p><b>Generated Narrative: Observation</b><a name="a531aee9-4c21-06af-352c-a3615b5d957e"> </a><a name="hca531aee9-4c21-06af-352c-a3615b5d957e"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "a531aee9-4c21-06af-352c-a3615b5d957e" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/2daba8ca-211f-4f4b-4028-16c30fe22ee8</p><p><b>status</b>: final</p><p><b>code</b>: Residual solvents <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#SOL)</span></p><p><b>subject</b>: See on this page: Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.1 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Solvent <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#SOLV)</span></td><td>Solvent 1 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Solvents -->
<reference
value="ObservationDefinition/2daba8ca-211f-4f4b-4028-16c30fe22ee8"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="SOL"/>
<display value="Residual solvents"/>
</coding>
</code>
<subject>
<!-- Substance/actual-batch-substance-2 -->
<reference value="Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.1"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="SOLV"/>
<display value="Solvent"/>
</coding>
</code>
<valueCodeableConcept>
<text value="Solvent 1"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:033ce81d-5f0d-7a3e-93d3-fc64e122a1fd"/>
<resource>
<Observation>
<!-- observationSolvents-sol1-3 -->
<id value="033ce81d-5f0d-7a3e-93d3-fc64e122a1fd"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_033ce81d-5f0d-7a3e-93d3-fc64e122a1fd"> </a><p><b>Generated Narrative: Observation</b><a name="033ce81d-5f0d-7a3e-93d3-fc64e122a1fd"> </a><a name="hc033ce81d-5f0d-7a3e-93d3-fc64e122a1fd"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "033ce81d-5f0d-7a3e-93d3-fc64e122a1fd" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/2daba8ca-211f-4f4b-4028-16c30fe22ee8</p><p><b>status</b>: final</p><p><b>code</b>: Residual solvents <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#SOL)</span></p><p><b>subject</b>: See on this page: Substance/ef17cff1-6586-a4a4-9168-2602140548d7</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.1 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Solvent <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#SOLV)</span></td><td>Solvent 1 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Solvents -->
<reference
value="ObservationDefinition/2daba8ca-211f-4f4b-4028-16c30fe22ee8"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="SOL"/>
<display value="Residual solvents"/>
</coding>
</code>
<subject>
<!-- Substance/actual-batch-substance-3 -->
<reference value="Substance/ef17cff1-6586-a4a4-9168-2602140548d7"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.1"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="SOLV"/>
<display value="Solvent"/>
</coding>
</code>
<valueCodeableConcept>
<text value="Solvent 1"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:ba8a182e-8571-6cbd-047b-612735d599d2"/>
<resource>
<Observation>
<!-- observationSolvents-sol2 -->
<id value="ba8a182e-8571-6cbd-047b-612735d599d2"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_ba8a182e-8571-6cbd-047b-612735d599d2"> </a><p><b>Generated Narrative: Observation</b><a name="ba8a182e-8571-6cbd-047b-612735d599d2"> </a><a name="hcba8a182e-8571-6cbd-047b-612735d599d2"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "ba8a182e-8571-6cbd-047b-612735d599d2" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/2daba8ca-211f-4f4b-4028-16c30fe22ee8</p><p><b>status</b>: final</p><p><b>code</b>: Residual solvents <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#SOL)</span></p><p><b>subject</b>: See on this page: Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 1.4 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Solvent <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#SOLV)</span></td><td>Solvent 2 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Solvents -->
<reference
value="ObservationDefinition/2daba8ca-211f-4f4b-4028-16c30fe22ee8"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="SOL"/>
<display value="Residual solvents"/>
</coding>
</code>
<subject>
<!-- Substance/substance-drug-pq-ex1 -->
<reference value="Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="1.4"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="SOLV"/>
<display value="Solvent"/>
</coding>
</code>
<valueCodeableConcept>
<text value="Solvent 2"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:0b5b94cc-7a1a-4ada-66c7-954ceb528d67"/>
<resource>
<Observation>
<!-- observationSolvents-sol2-2 -->
<id value="0b5b94cc-7a1a-4ada-66c7-954ceb528d67"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_0b5b94cc-7a1a-4ada-66c7-954ceb528d67"> </a><p><b>Generated Narrative: Observation</b><a name="0b5b94cc-7a1a-4ada-66c7-954ceb528d67"> </a><a name="hc0b5b94cc-7a1a-4ada-66c7-954ceb528d67"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "0b5b94cc-7a1a-4ada-66c7-954ceb528d67" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/2daba8ca-211f-4f4b-4028-16c30fe22ee8</p><p><b>status</b>: final</p><p><b>code</b>: Residual solvents <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#SOL)</span></p><p><b>subject</b>: See on this page: Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 1.5 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Solvent <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#SOLV)</span></td><td>Solvent 2 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Solvents -->
<reference
value="ObservationDefinition/2daba8ca-211f-4f4b-4028-16c30fe22ee8"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="SOL"/>
<display value="Residual solvents"/>
</coding>
</code>
<subject>
<!-- Substance/actual-batch-substance-2 -->
<reference value="Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="1.5"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="SOLV"/>
<display value="Solvent"/>
</coding>
</code>
<valueCodeableConcept>
<text value="Solvent 2"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:6afaacee-11a6-58b2-47df-5f79722c66ac"/>
<resource>
<Observation>
<!-- observationSolvents-sol2-3 -->
<id value="6afaacee-11a6-58b2-47df-5f79722c66ac"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_6afaacee-11a6-58b2-47df-5f79722c66ac"> </a><p><b>Generated Narrative: Observation</b><a name="6afaacee-11a6-58b2-47df-5f79722c66ac"> </a><a name="hc6afaacee-11a6-58b2-47df-5f79722c66ac"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "6afaacee-11a6-58b2-47df-5f79722c66ac" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/2daba8ca-211f-4f4b-4028-16c30fe22ee8</p><p><b>status</b>: final</p><p><b>code</b>: Residual solvents <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#SOL)</span></p><p><b>subject</b>: See on this page: Substance/ef17cff1-6586-a4a4-9168-2602140548d7</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 1.2 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Solvent <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#SOLV)</span></td><td>Solvent 2 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Solvents -->
<reference
value="ObservationDefinition/2daba8ca-211f-4f4b-4028-16c30fe22ee8"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="SOL"/>
<display value="Residual solvents"/>
</coding>
</code>
<subject>
<!-- Substance/actual-batch-substance-3 -->
<reference value="Substance/ef17cff1-6586-a4a4-9168-2602140548d7"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="1.2"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="SOLV"/>
<display value="Solvent"/>
</coding>
</code>
<valueCodeableConcept>
<text value="Solvent 2"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:c2644a86-1684-286e-00e2-dcaf907a8970"/>
<resource>
<Observation>
<!-- observationWater -->
<id value="c2644a86-1684-286e-00e2-dcaf907a8970"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_c2644a86-1684-286e-00e2-dcaf907a8970"> </a><p><b>Generated Narrative: Observation</b><a name="c2644a86-1684-286e-00e2-dcaf907a8970"> </a><a name="hcc2644a86-1684-286e-00e2-dcaf907a8970"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "c2644a86-1684-286e-00e2-dcaf907a8970" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/17b322fe-53ea-6c1f-521b-3b148ac05eb4</p><p><b>status</b>: final</p><p><b>code</b>: Water Content <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#WaterContent)</span></p><p><b>subject</b>: See on this page: Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.8 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Water -->
<reference
value="ObservationDefinition/17b322fe-53ea-6c1f-521b-3b148ac05eb4"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="WaterContent"/>
<display value="Water Content"/>
</coding>
<text value="Water Content"/>
</code>
<subject>
<!-- Substance/substance-drug-pq-ex1 -->
<reference value="Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.8"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:cb5f6872-6eeb-727a-7c33-f2c438581a1c"/>
<resource>
<Observation>
<!-- observationWater2 -->
<id value="cb5f6872-6eeb-727a-7c33-f2c438581a1c"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_cb5f6872-6eeb-727a-7c33-f2c438581a1c"> </a><p><b>Generated Narrative: Observation</b><a name="cb5f6872-6eeb-727a-7c33-f2c438581a1c"> </a><a name="hccb5f6872-6eeb-727a-7c33-f2c438581a1c"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "cb5f6872-6eeb-727a-7c33-f2c438581a1c" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/17b322fe-53ea-6c1f-521b-3b148ac05eb4</p><p><b>status</b>: final</p><p><b>code</b>: Water Content <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#WaterContent)</span></p><p><b>subject</b>: See on this page: Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.8 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Water -->
<reference
value="ObservationDefinition/17b322fe-53ea-6c1f-521b-3b148ac05eb4"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="WaterContent"/>
<display value="Water Content"/>
</coding>
<text value="Water Content"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-2 -->
<reference value="Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.8"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:7faaf980-7c10-7b9a-9572-1bacd485824e"/>
<resource>
<Observation>
<!-- observationWater3 -->
<id value="7faaf980-7c10-7b9a-9572-1bacd485824e"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_7faaf980-7c10-7b9a-9572-1bacd485824e"> </a><p><b>Generated Narrative: Observation</b><a name="7faaf980-7c10-7b9a-9572-1bacd485824e"> </a><a name="hc7faaf980-7c10-7b9a-9572-1bacd485824e"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "7faaf980-7c10-7b9a-9572-1bacd485824e" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/17b322fe-53ea-6c1f-521b-3b148ac05eb4</p><p><b>status</b>: final</p><p><b>code</b>: Water Content <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#WaterContent)</span></p><p><b>subject</b>: See on this page: Substance/ef17cff1-6586-a4a4-9168-2602140548d7</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.8 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Water -->
<reference
value="ObservationDefinition/17b322fe-53ea-6c1f-521b-3b148ac05eb4"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="WaterContent"/>
<display value="Water Content"/>
</coding>
<text value="Water Content"/>
</code>
<subject>
<!-- Substance/actual-batch-substance-3 -->
<reference value="Substance/ef17cff1-6586-a4a4-9168-2602140548d7"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.8"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:e4d2118a-8562-9eb1-2c14-4e145d2a95fc"/>
<resource>
<Observation>
<!-- observationParticleSize-size1 -->
<id value="e4d2118a-8562-9eb1-2c14-4e145d2a95fc"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_e4d2118a-8562-9eb1-2c14-4e145d2a95fc"> </a><p><b>Generated Narrative: Observation</b><a name="e4d2118a-8562-9eb1-2c14-4e145d2a95fc"> </a><a name="hce4d2118a-8562-9eb1-2c14-4e145d2a95fc"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "e4d2118a-8562-9eb1-2c14-4e145d2a95fc" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/11fcfe6b-7498-132b-2def-efae51b302d4</p><p><b>status</b>: final</p><p><b>code</b>: Particle size distribution <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#PART)</span></p><p><b>subject</b>: See on this page: Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.5 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Impurity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IMP)</span></td><td>D(v,0.9) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Particles -->
<reference
value="ObservationDefinition/11fcfe6b-7498-132b-2def-efae51b302d4"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="PART"/>
<display value="Particle size distribution"/>
</coding>
</code>
<subject>
<!-- Substance/substance-drug-pq-ex1 -->
<reference value="Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.5"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="IMP"/>
<display value="Impurity"/>
</coding>
</code>
<valueCodeableConcept>
<text value="D(v,0.9)"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:ec078717-9512-4db4-77c6-2c7e29d213a6"/>
<resource>
<Observation>
<!-- observationParticleSize-size1-2 -->
<id value="ec078717-9512-4db4-77c6-2c7e29d213a6"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_ec078717-9512-4db4-77c6-2c7e29d213a6"> </a><p><b>Generated Narrative: Observation</b><a name="ec078717-9512-4db4-77c6-2c7e29d213a6"> </a><a name="hcec078717-9512-4db4-77c6-2c7e29d213a6"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "ec078717-9512-4db4-77c6-2c7e29d213a6" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/11fcfe6b-7498-132b-2def-efae51b302d4</p><p><b>status</b>: final</p><p><b>code</b>: Particle size distribution <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#PART)</span></p><p><b>subject</b>: See on this page: Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.4 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Impurity <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#IMP)</span></td><td>D(v,0.9) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Particles -->
<reference
value="ObservationDefinition/11fcfe6b-7498-132b-2def-efae51b302d4"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="PART"/>
<display value="Particle size distribution"/>
</coding>
</code>
<subject>
<!-- Substance/actual-batch-substance-2 -->
<reference value="Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.4"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="IMP"/>
<display value="Impurity"/>
</coding>
</code>
<valueCodeableConcept>
<text value="D(v,0.9)"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:05cfb495-2580-561a-688d-ce6ea24c8962"/>
<resource>
<Observation>
<!-- observationParticleSize-size1-3 -->
<id value="05cfb495-2580-561a-688d-ce6ea24c8962"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_05cfb495-2580-561a-688d-ce6ea24c8962"> </a><p><b>Generated Narrative: Observation</b><a name="05cfb495-2580-561a-688d-ce6ea24c8962"> </a><a name="hc05cfb495-2580-561a-688d-ce6ea24c8962"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "05cfb495-2580-561a-688d-ce6ea24c8962" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/11fcfe6b-7498-132b-2def-efae51b302d4</p><p><b>status</b>: final</p><p><b>code</b>: Particle size distribution <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#PART)</span></p><p><b>subject</b>: See on this page: Substance/ef17cff1-6586-a4a4-9168-2602140548d7</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.2 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Particle Size <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#SIZE)</span></td><td>D(v,0.9) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Particles -->
<reference
value="ObservationDefinition/11fcfe6b-7498-132b-2def-efae51b302d4"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="PART"/>
<display value="Particle size distribution"/>
</coding>
</code>
<subject>
<!-- Substance/actual-batch-substance-3 -->
<reference value="Substance/ef17cff1-6586-a4a4-9168-2602140548d7"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.2"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="SIZE"/>
<display value="Particle Size"/>
</coding>
</code>
<valueCodeableConcept>
<text value="D(v,0.9)"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:d2a60ae5-96b4-3d13-38da-729c652347a3"/>
<resource>
<Observation>
<!-- observationParticleSize-size2 -->
<id value="d2a60ae5-96b4-3d13-38da-729c652347a3"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_d2a60ae5-96b4-3d13-38da-729c652347a3"> </a><p><b>Generated Narrative: Observation</b><a name="d2a60ae5-96b4-3d13-38da-729c652347a3"> </a><a name="hcd2a60ae5-96b4-3d13-38da-729c652347a3"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "d2a60ae5-96b4-3d13-38da-729c652347a3" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/11fcfe6b-7498-132b-2def-efae51b302d4</p><p><b>status</b>: final</p><p><b>code</b>: Particle size distribution <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#PART)</span></p><p><b>subject</b>: See on this page: Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.5 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Particle Size <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#SIZE)</span></td><td>D(v,0.5) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Particles -->
<reference
value="ObservationDefinition/11fcfe6b-7498-132b-2def-efae51b302d4"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="PART"/>
<display value="Particle size distribution"/>
</coding>
</code>
<subject>
<!-- Substance/substance-drug-pq-ex1 -->
<reference value="Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.5"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="SIZE"/>
<display value="Particle Size"/>
</coding>
</code>
<valueCodeableConcept>
<text value="D(v,0.5)"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:c3f51325-2f5f-194c-919b-2219ee1f5c45"/>
<resource>
<Observation>
<!-- observationParticleSize-size2-2 -->
<id value="c3f51325-2f5f-194c-919b-2219ee1f5c45"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_c3f51325-2f5f-194c-919b-2219ee1f5c45"> </a><p><b>Generated Narrative: Observation</b><a name="c3f51325-2f5f-194c-919b-2219ee1f5c45"> </a><a name="hcc3f51325-2f5f-194c-919b-2219ee1f5c45"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "c3f51325-2f5f-194c-919b-2219ee1f5c45" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/11fcfe6b-7498-132b-2def-efae51b302d4</p><p><b>status</b>: final</p><p><b>code</b>: Particle size distribution <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#PART)</span></p><p><b>subject</b>: See on this page: Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.4 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Particle Size <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#SIZE)</span></td><td>D(v,0.5) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Particles -->
<reference
value="ObservationDefinition/11fcfe6b-7498-132b-2def-efae51b302d4"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="PART"/>
<display value="Particle size distribution"/>
</coding>
</code>
<subject>
<!-- Substance/actual-batch-substance-2 -->
<reference value="Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.4"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="SIZE"/>
<display value="Particle Size"/>
</coding>
</code>
<valueCodeableConcept>
<text value="D(v,0.5)"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:e9d89693-11b1-13ed-5cde-606fc1b8372c"/>
<resource>
<Observation>
<!-- observationParticleSize-size2-3 -->
<id value="e9d89693-11b1-13ed-5cde-606fc1b8372c"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_e9d89693-11b1-13ed-5cde-606fc1b8372c"> </a><p><b>Generated Narrative: Observation</b><a name="e9d89693-11b1-13ed-5cde-606fc1b8372c"> </a><a name="hce9d89693-11b1-13ed-5cde-606fc1b8372c"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "e9d89693-11b1-13ed-5cde-606fc1b8372c" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/11fcfe6b-7498-132b-2def-efae51b302d4</p><p><b>status</b>: final</p><p><b>code</b>: Particle size distribution <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#PART)</span></p><p><b>subject</b>: See on this page: Substance/ef17cff1-6586-a4a4-9168-2602140548d7</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.2 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Particle Size <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#SIZE)</span></td><td>D(v,0.5) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Particles -->
<reference
value="ObservationDefinition/11fcfe6b-7498-132b-2def-efae51b302d4"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="PART"/>
<display value="Particle size distribution"/>
</coding>
</code>
<subject>
<!-- Substance/actual-batch-substance-3 -->
<reference value="Substance/ef17cff1-6586-a4a4-9168-2602140548d7"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.2"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="SIZE"/>
<display value="Particle Size"/>
</coding>
</code>
<valueCodeableConcept>
<text value="D(v,0.5)"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:2659b000-96e2-1b8b-129b-0c00e1074b0f"/>
<resource>
<Observation>
<!-- observationParticleSize-size3 -->
<id value="2659b000-96e2-1b8b-129b-0c00e1074b0f"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_2659b000-96e2-1b8b-129b-0c00e1074b0f"> </a><p><b>Generated Narrative: Observation</b><a name="2659b000-96e2-1b8b-129b-0c00e1074b0f"> </a><a name="hc2659b000-96e2-1b8b-129b-0c00e1074b0f"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "2659b000-96e2-1b8b-129b-0c00e1074b0f" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/11fcfe6b-7498-132b-2def-efae51b302d4</p><p><b>status</b>: final</p><p><b>code</b>: Particle size distribution <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#PART)</span></p><p><b>subject</b>: See on this page: Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.1 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Particle Size <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#SIZE)</span></td><td>D(v,0.1) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Particles -->
<reference
value="ObservationDefinition/11fcfe6b-7498-132b-2def-efae51b302d4"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="PART"/>
<display value="Particle size distribution"/>
</coding>
</code>
<subject>
<!-- Substance/substance-drug-pq-ex1 -->
<reference value="Substance/87ef899b-14dd-26b7-7416-7ec1d01b62a1"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.1"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="SIZE"/>
<display value="Particle Size"/>
</coding>
</code>
<valueCodeableConcept>
<text value="D(v,0.1)"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:10b47328-36fa-343d-5699-5b32b30a6d33"/>
<resource>
<Observation>
<!-- observationParticleSize-size3-2 -->
<id value="10b47328-36fa-343d-5699-5b32b30a6d33"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_10b47328-36fa-343d-5699-5b32b30a6d33"> </a><p><b>Generated Narrative: Observation</b><a name="10b47328-36fa-343d-5699-5b32b30a6d33"> </a><a name="hc10b47328-36fa-343d-5699-5b32b30a6d33"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "10b47328-36fa-343d-5699-5b32b30a6d33" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/11fcfe6b-7498-132b-2def-efae51b302d4</p><p><b>status</b>: final</p><p><b>code</b>: Particle size distribution <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#PART)</span></p><p><b>subject</b>: See on this page: Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.1 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Particle Size <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#SIZE)</span></td><td>D(v,0.1) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Particles -->
<reference
value="ObservationDefinition/11fcfe6b-7498-132b-2def-efae51b302d4"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="PART"/>
<display value="Particle size distribution"/>
</coding>
</code>
<subject>
<!-- Substance/actual-batch-substance-2 -->
<reference value="Substance/6412c5d4-1b7d-8405-85dc-75dbaa300ea4"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.1"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="SIZE"/>
<display value="Particle Size"/>
</coding>
</code>
<valueCodeableConcept>
<text value="D(v,0.1)"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
<entry>
<fullUrl value="urn:uuid:e6780766-317a-382f-92d2-79825f506cc5"/>
<resource>
<Observation>
<!-- observationParticleSize-size3-3 -->
<id value="e6780766-317a-382f-92d2-79825f506cc5"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_e6780766-317a-382f-92d2-79825f506cc5"> </a><p><b>Generated Narrative: Observation</b><a name="e6780766-317a-382f-92d2-79825f506cc5"> </a><a name="hce6780766-317a-382f-92d2-79825f506cc5"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation "e6780766-317a-382f-92d2-79825f506cc5" </p></div><p><b>instantiates</b>: See on this page: ObservationDefinition/11fcfe6b-7498-132b-2def-efae51b302d4</p><p><b>status</b>: final</p><p><b>code</b>: Particle size distribution <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#PART)</span></p><p><b>subject</b>: See on this page: Substance/ef17cff1-6586-a4a4-9168-2602140548d7</p><p><b>effective</b>: 2023-01-01 12:00:00+0000</p><p><b>performer</b>: See on this page: Organization/378fbe5f-5926-3a5c-4c64-5428df877b08</p><p><b>value</b>: 0.1 % w/w<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Particle Size <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="CodeSystem-cs-local-codes-drug-pq-example.html">Example Local Codes - Drug</a>#SIZE)</span></td><td>D(v,0.1) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> ()</span></td></tr></table></div>
</text>
<instantiatesReference>
<!-- ObservationDefinition/Particles -->
<reference
value="ObservationDefinition/11fcfe6b-7498-132b-2def-efae51b302d4"/>
</instantiatesReference>
<status value="final"/>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="PART"/>
<display value="Particle size distribution"/>
</coding>
</code>
<subject>
<!-- Substance/actual-batch-substance-3 -->
<reference value="Substance/ef17cff1-6586-a4a4-9168-2602140548d7"/>
</subject>
<effectiveDateTime value="2023-01-01T12:00:00Z"/>
<performer>
<!-- Organization/378fbe5f-5926-3a5c-4c64-5428df877b08 -->
<reference
value="Organization/378fbe5f-5926-3a5c-4c64-5428df877b08"/>
</performer>
<valueQuantity>
<value value="0.1"/>
<unit value="% w/w"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/pharm-quality/CodeSystem/cs-local-codes-drug-pq-example"/>
<code value="SIZE"/>
<display value="Particle Size"/>
</coding>
</code>
<valueCodeableConcept>
<text value="D(v,0.1)"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
</entry>
</Bundle>
IG © HL7 International / Biomedical Research and Regulation. Package hl7.fhir.uv.pharm-quality#1.0.0 based on FHIR 5.0.0. Generated 2024-05-08
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