This page is part of the Evidence Based Medicine on FHIR Implementation Guide (v1.0.0-ballot2: STU1 Ballot 2) based on FHIR (HL7® FHIR® Standard) v6.0.0. No current official version has been published yet. For a full list of available versions, see the Directory of published versions

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: NetEffectContribution: Remission of diabetes for Example for GIN 2022 - XML Representation

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<Evidence xmlns="http://hl7.org/fhir">
  <id value="179588"/>
  <meta>
    <versionId value="12"/>
    <lastUpdated value="2025-03-16T09:43:10.014Z"/>
    <profile
             value="http://hl7.org/fhir/uv/ebm/StructureDefinition/net-effect-contribution"/>
  </meta>
  <text>
    <status value="empty"/>
    <div xmlns="http://www.w3.org/1999/xhtml"><p>[No data.]</p></div>
  </text>
  <extension url="http://hl7.org/fhir/uv/ebm/StructureDefinition/cite-as">
    <valueMarkdown
                   value="NetEffectContribution: Remission of diabetes for Example for GIN 2022 [Database Entry: FHIR Evidence Resource]. Contributors: Brian S. Alper [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 179588. Revised 2025-03-05. Available at: https://fevir.net/resources/Evidence/179588. Computable resource at: https://fevir.net/resources/Evidence/179588#json."/>
  </extension>
  <url value="https://fevir.net/resources/Evidence/179588"/>
  <identifier>
    <type>
      <coding>
        <system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
        <code value="ACSN"/>
        <display value="Accession ID"/>
      </coding>
      <text value="FEvIR Object Identifier"/>
    </type>
    <system value="urn:ietf:rfc:3986"/>
    <value value="https://fevir.net/FOI/179588"/>
    <assigner>
      <display value="Computable Publishing LLC"/>
    </assigner>
  </identifier>
  <name
        value="NetEffectContribution_Remission_of_diabetes_for_Example_for_GIN_2022"/>
  <title
         value="NetEffectContribution: Remission of diabetes for Example for GIN 2022"/>
  <status value="active"/>
  <publisher value="Computable Publishing LLC"/>
  <contact>
    <telecom>
      <system value="email"/>
      <value value="support@computablepublishing.com"/>
    </telecom>
  </contact>
  <author>
    <name value="Brian S. Alper"/>
  </author>
  <useContext>
    <code>
      <system value="https://fevir.net/resources/CodeSystem/179423"/>
      <code value="evidence-communication"/>
      <display value="Evidence Communication"/>
    </code>
    <valueCodeableConcept>
      <coding>
        <system value="https://fevir.net/resources/CodeSystem/179423"/>
        <code value="ComparativeEvidence"/>
        <display value="ComparativeEvidence"/>
      </coding>
    </valueCodeableConcept>
  </useContext>
  <useContext>
    <code>
      <system value="https://fevir.net/resources/CodeSystem/179423"/>
      <code value="evidence-communication"/>
      <display value="Evidence Communication"/>
    </code>
    <valueCodeableConcept>
      <coding>
        <system value="https://fevir.net/resources/CodeSystem/179423"/>
        <code value="NetEffectContribution"/>
        <display value="NetEffectContribution"/>
      </coding>
    </valueCodeableConcept>
  </useContext>
  <copyright value="https://creativecommons.org/licenses/by-nc-sa/4.0/"/>
  <description
               value="2.15 (1.33 to 3.26) - example showing statistic.extension:modelExpression"/>
  <variableDefinition>
    <description
                 value="Cohort study with baseline data of exposures from November 2005 through July 2010 and follow-up data from 2006 until death or through December 2015 at a tertiary care outpatient center, Vestfold Hospital Trust, Norway. Consecutive treatment-seeking adult patients (n = 2109) with severe obesity assessed (221 patients excluded and 1888 patients included)."/>
    <variableRole value="population"/>
    <observed>🔗 
      <reference value="Group/178427"/>
      <type value="Group"/>
      <display
               value="StudyGroup: Severely Obese Adults 2018 Norwegian Cohort"/>
    </observed>
  </variableDefinition>
  <variableDefinition>
    <description
                 value="comparison groups of bariatric surgery vs. no bariatric surgery"/>
    <variableRole value="exposure"/>
    <comparatorCategory value="no bariatric surgery"/>
    <observed>🔗 
      <reference value="EvidenceVariable/172427"/>
      <type value="EvidenceVariable"/>
      <display
               value="GroupAssignment: Bariatric Surgery vs. no bariatric surgery"/>
    </observed>
  </variableDefinition>
  <variableDefinition>
    <description value="Remission of diabetes"/>
    <variableRole value="outcome"/>
    <observed>🔗 
      <reference value="EvidenceVariable/104117"/>
      <type value="EvidenceVariable"/>
      <display value="OutcomeVariable: Remission of diabetes"/>
    </observed>
  </variableDefinition>
  <variableDefinition>
    <extension
               url="http://hl7.org/fhir/uv/ebm/StructureDefinition/relative-outcome-importance">
      <valueReference>🔗 
        <reference value="ArtifactAssessment/104193"/>
        <type value="ArtifactAssessment"/>
        <display
                 value="Outcome Importance Rating 5% of Remission of diabetes"/>
      </valueReference>
    </extension>
    <description value="Relative Importance Multiplier"/>
    <variableRole value="covariate"/>
    <roleSubtype>
      <coding>
        <system value="https://fevir.net/resources/CodeSystem/179423"/>
        <code value="importance-multiplier"/>
        <display value="Relative importance multiplier"/>
      </coding>
    </roleSubtype>
    <observed>
      <display value="Relative Importance Multiplier"/>
    </observed>
  </variableDefinition>
  <statistic>
    <extension
               url="http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-expression">
      <valueExpression>
        <description
                     value="risk difference (relative risk x control event rate) multiplied by relative importance multiplier (defined in OutcomeImportance Profile) -- expression is pseudocode to demonstrate the concept"/>
        <name value="Net effect contribution analysis"/>
        <expression
                    value="Evidence[id='104121'].statistic[statisticType='Relative Risk'] * Evidence[id='104396'].statistic[statisticType='Proportion'] * ArtifactAssessment[id='104193'].content[type.text='Outcome Importance'].quantity"/>
      </valueExpression>
    </extension>
    <description value="risk difference 2.15 (95% CI 1.33 to 3.26)"/>
    <statisticType>
      <coding>
        <system value="https://fevir.net/sevco"/>
        <code value="STATO:0000424"/>
        <display value="risk difference"/>
      </coding>
    </statisticType>
    <quantity>
      <value value="2.15"/>
    </quantity>
    <attributeEstimate>
      <description value="95% CI 1.33 to 3.26"/>
      <type>
        <coding>
          <system value="https://fevir.net/sevco"/>
          <code value="STATO:0000196"/>
          <display value="confidence interval"/>
        </coding>
      </type>
      <level value="0.95"/>
      <range>
        <low>
          <value value="1.33"/>
        </low>
        <high>
          <value value="3.26"/>
        </high>
      </range>
    </attributeEstimate>
    <modelCharacteristic>
      <code>
        <text value="Net effect contribution analysis"/>
      </code>
    </modelCharacteristic>
  </statistic>
</Evidence>