This page is part of the Evidence Based Medicine on FHIR Implementation Guide (v1.0.0-ballot: STU1 Ballot 1) based on FHIR (HL7® FHIR® Standard) v5.0.0. . For a full list of available versions, see the Directory of published versions
: Therapeutic-dose anticoagulation with heparin - TTL Representation
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@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
# - resource -------------------------------------------------------------------
a fhir:EvidenceVariable ;
fhir:nodeRole fhir:treeRoot ;
fhir:id [ fhir:v "7751"] ; #
fhir:meta [
fhir:versionId [ fhir:v "12" ]
] ; #
fhir:text [
fhir:status [ fhir:v "extensions" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: EvidenceVariable</b><a name=\"7751\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource EvidenceVariable "7751" Version "12" </p></div><p><b>StructureDefinition Work Group</b>: cds</p><p><b>url</b>: <code>https://fevir.net/resources/EvidenceVariable/7751</code></p><p><b>identifier</b>: FEvIR Object Identifier: 7751</p><p><b>version</b>: 1.0.0-ballot</p><p><b>name</b>: Therapeutic_dose_anticoagulation_with_heparin</p><p><b>title</b>: Therapeutic-dose anticoagulation with heparin</p><p><b>status</b>: active</p><p><b>date</b>: 2022-08-05 14:37:53+0000</p><p><b>publisher</b>: HL7 International / Clinical Decision Support</p><p><b>contact</b>: HL7 International / Clinical Decision Support: <a href=\"http://www.hl7.org/Special/committees/dss\">http://www.hl7.org/Special/committees/dss</a></p><p><b>description</b>: Therapeutic-dose anticoagulation with unfractionated or low-molecular-weight heparin was administered according to local protocols for the treatment of acute venous thromboembolism for up to 14 days or until recovery; the latter was defined as hospital discharge or a discontinuation of supplemental oxygen for at least 24 hours.</p><p><b>copyright</b>: https://creativecommons.org/licenses/by-nc-sa/4.0/</p><p><b>author</b>: Brian S. Alper: </p><blockquote><p><b>characteristic</b></p><blockquote><p><b>definitionByCombination</b></p><p><b>code</b>: any-of</p><blockquote><p><b>characteristic</b></p><p><b>definitionCodeableConcept</b>: ATTACC investigational arm: Therapeutic anticoagulation for 14 days (or until hospital discharge or liberation from the need for supplemental oxygen, whichever comes first) with preference for low-molecular weight heparin (LMWH), or alternative unfractionated heparin (UFH). LMWH dosed according to patient weight and creatinine clearance according to local practice and policy. For UFH, suggested target of aPTT 1.5 to 2.5 times the upper limit of normal or therapeutic anti-Xa levels. <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><blockquote><p><b>timeFromEvent</b></p></blockquote></blockquote><blockquote><p><b>characteristic</b></p><p><b>definitionCodeableConcept</b>: ACTIV-4a investigational arm: Low-molecular weight heparin (LMWH) dosed according to patient weight and creatinine clearance. For UFH, suggested target of anti-Xa of 0.3-0.7 IU/ml or aPTT 1.5 to 2.5 times the upper limit of normal. <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><blockquote><p><b>timeFromEvent</b></p></blockquote></blockquote><blockquote><p><b>characteristic</b></p><p><b>definitionCodeableConcept</b>: REMAP-CAP investigational arm: Dosed according to local hospital policy, practice, and guidelines for treatment of venous thromboembolism. Low-molecular weight heparin (LMWH) dosed according to patient weight. For UFH, suggested target for aPTT of 1.5 to 2.5 times the upper limit of normal or therapeutic anti-Xa levels. <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><blockquote><p><b>timeFromEvent</b></p></blockquote></blockquote></blockquote></blockquote></div>"
] ; #
fhir:extension ( [
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg"^^xsd:anyURI ] ;
fhir:value [ fhir:v "cds" ]
] ) ; #
fhir:url [ fhir:v "https://fevir.net/resources/EvidenceVariable/7751"^^xsd:anyURI] ; #
fhir:identifier ( [
fhir:type [
( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ;
fhir:code [ fhir:v "ACSN" ] ;
fhir:display [ fhir:v "Accession ID" ] ] ) ;
fhir:text [ fhir:v "FEvIR Object Identifier" ] ] ;
fhir:system [ fhir:v "https://fevir.net"^^xsd:anyURI ] ;
fhir:value [ fhir:v "7751" ] ;
fhir:assigner [
fhir:display [ fhir:v "Computable Publishing LLC" ] ]
] ) ; #
fhir:version [ fhir:v "1.0.0-ballot"] ; #
fhir:name [ fhir:v "Therapeutic_dose_anticoagulation_with_heparin"] ; #
fhir:title [ fhir:v "Therapeutic-dose anticoagulation with heparin"] ; #
fhir:status [ fhir:v "active"] ; #
fhir:date [ fhir:v "2022-08-05T14:37:53.832Z"^^xsd:dateTime] ; #
fhir:publisher [ fhir:v "HL7 International / Clinical Decision Support"] ; #
fhir:contact ( [
fhir:name [ fhir:v "HL7 International / Clinical Decision Support" ] ;
( fhir:telecom [
fhir:system [ fhir:v "url" ] ;
fhir:value [ fhir:v "http://www.hl7.org/Special/committees/dss" ] ] )
] ) ; #
fhir:description [ fhir:v "Therapeutic-dose anticoagulation with unfractionated or low-molecular-weight heparin was administered according to local protocols for the treatment of acute venous thromboembolism for up to 14 days or until recovery; the latter was defined as hospital discharge or a discontinuation of supplemental oxygen for at least 24 hours."] ; #
fhir:copyright [ fhir:v "https://creativecommons.org/licenses/by-nc-sa/4.0/"] ; #
fhir:author ( [
fhir:name [ fhir:v "Brian S. Alper" ]
] ) ; #
fhir:characteristic ( [
fhir:definitionByCombination [
fhir:code [ fhir:v "any-of" ] ;
( fhir:characteristic [
fhir:definitionCodeableConcept [
fhir:text [ fhir:v "ATTACC investigational arm: Therapeutic anticoagulation for 14 days (or until hospital discharge or liberation from the need for supplemental oxygen, whichever comes first) with preference for low-molecular weight heparin (LMWH), or alternative unfractionated heparin (UFH). LMWH dosed according to patient weight and creatinine clearance according to local practice and policy. For UFH, suggested target of aPTT 1.5 to 2.5 times the upper limit of normal or therapeutic anti-Xa levels." ] ] ;
( fhir:timeFromEvent [
fhir:description [ fhir:v "Up to 14 days or until hospital discharge or recovery (defined as liberation from supplemental oxygen>24 hours, provided oxygen was required), whichever comes first." ] ;
fhir:range [
fhir:low [
fhir:value [ fhir:v "0"^^xsd:decimal ] ;
fhir:unit [ fhir:v "days" ] ] ;
fhir:high [
fhir:value [ fhir:v "14"^^xsd:decimal ] ;
fhir:unit [ fhir:v "days" ] ] ] ] ) ] [
fhir:definitionCodeableConcept [
fhir:text [ fhir:v "ACTIV-4a investigational arm: Low-molecular weight heparin (LMWH) dosed according to patient weight and creatinine clearance. For UFH, suggested target of anti-Xa of 0.3-0.7 IU/ml or aPTT 1.5 to 2.5 times the upper limit of normal." ] ] ;
( fhir:timeFromEvent [
fhir:description [ fhir:v "Up to 14 days or until hospital discharge, whichever comes first." ] ;
fhir:range [
fhir:low [
fhir:value [ fhir:v "0"^^xsd:decimal ] ;
fhir:unit [ fhir:v "days" ] ] ;
fhir:high [
fhir:value [ fhir:v "14"^^xsd:decimal ] ;
fhir:unit [ fhir:v "days" ] ] ] ] ) ] [
fhir:definitionCodeableConcept [
fhir:text [ fhir:v "REMAP-CAP investigational arm: Dosed according to local hospital policy, practice, and guidelines for treatment of venous thromboembolism. Low-molecular weight heparin (LMWH) dosed according to patient weight. For UFH, suggested target for aPTT of 1.5 to 2.5 times the upper limit of normal or therapeutic anti-Xa levels." ] ] ;
( fhir:timeFromEvent [
fhir:description [ fhir:v "Up to 14 days or until hospital discharge, whichever comes first." ] ;
fhir:range [
fhir:low [
fhir:value [ fhir:v "0"^^xsd:decimal ] ;
fhir:unit [ fhir:v "days" ] ] ;
fhir:high [
fhir:value [ fhir:v "14"^^xsd:decimal ] ;
fhir:unit [ fhir:v "days" ] ] ] ] ) ] ) ]
] ) . #
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