Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot - ballot International flag

This page is part of the Evidence Based Medicine on FHIR Implementation Guide (v1.0.0-ballot: STU1 Ballot 1) based on FHIR (HL7® FHIR® Standard) v5.0.0. . For a full list of available versions, see the Directory of published versions

Example Evidence: ComparativeEvidence: Mean difference in HbA1c between Surgery and Medical/Lifestyle groups in Ikramuddin 2015

Active as of 2022-05-29

Generated Narrative: Evidence

Resource Evidence "47762" Version "14" Updated "2023-12-06 18:56:02+0000"

Profiles: ComparativeEvidence, SingleStudyEvidence

StructureDefinition Work Group: cds

url: https://fevir.net/resources/Evidence/47762

identifier: FEvIR Object Identifier: 47762

version: 1.0.0-ballot

name: ComparativeEvidence_Mean_difference_in_HbA1c_between_Surgery_and_Medical_Lifestyle_groups_in_Ikramuddin_2015

title: ComparativeEvidence: Mean difference in HbA1c between Surgery and Medical/Lifestyle groups in Ikramuddin 2015

status: active

date: 2022-05-29 11:01:10+0000

publisher: HL7 International / Clinical Decision Support

contact: HL7 International / Clinical Decision Support: http://www.hl7.org/Special/committees/dss

author: Brian S. Alper:

UseContexts

-CodeValue[x]
*Evidence Communication (Details: https://fevir.net/resources/CodeSystem/179423 code evidence-communication = 'Evidence Communication', stated as 'Evidence Communication')ComparativeEvidence (Evidence Based Medicine on FHIR Implementation Guide Code System#ComparativeEvidence)
*Evidence Communication (Details: https://fevir.net/resources/CodeSystem/179423 code evidence-communication = 'Evidence Communication', stated as 'Evidence Communication')SingleStudyEvidence (Evidence Based Medicine on FHIR Implementation Guide Code System#SingleStudyEvidence)

copyright: https://creativecommons.org/licenses/by-nc-sa/4.0/

relatedArtifact

type: derived-from

label: data source

display: Figure 2C

citation: Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: A Joint Statement by International Diabetes Organizations [Journal Article]. Contributors: Francesco Rubino, David M Nathan, Robert H Eckel, Philip R Schauer, K George M M Alberti, Paul Z Zimmet, Stefano Del Prato, Linong Ji, Shaukat M Sadikot, William H Herman, Stephanie A Amiel, Lee M Kaplan, Gaspar Taroncher-Oldenburg, David E Cummings, Delegates of the 2nd Diabetes Surgery Summit. In: Diabetes care, PMID 27222544. Published June 2016. Available at: https://pubmed.ncbi.nlm.nih.gov/27222544/.

document

relatedArtifact

type: cite-as

citation: ComparativeEvidence: Mean difference in HbA1c between Surgery and Medical/Lifestyle groups in Ikramuddin 2015 [Evidence]. Contributors: In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 47762. Revised 2022-05-29. Available at: https://fevir.net/resources/Evidence/47762. Computable resource at: https://fevir.net/resources/Evidence/47762.

description: Mean HbA1c at 24 months in Ikramuddin 2015 was 6.5% in Surgery group (n = 56) and 8.4% in Medical/Lifestyle group (n = 54), mean difference -1.90% (95% CI -2.78% to -1.02%)

variableDefinition

VariableDefinitionVariableRoleCode: population

description: 110 patients aged 30-67 years with HbA1c of at least 8%, BMI between 30 and 39.9 and T2DM for at least 6 months

note: population

variableRole: Use extension:variableRoleCode instead. (EvidenceVariableRole#population "population")

observed: : Ikramuddin 2015 (Diabetes Surgery Study) Trial Enrollment Group

variableDefinition

VariableDefinitionVariableRoleCode: exposure

VariableDefinitionComparatorCategory: Lifestyle-intensive medical management intervention based on the Diabetes Prevention Program and LookAHEAD trials for 2 years

description: Roux-en-Y gastric bypass vs. medical treatment (intensive lifestyle and medical management)

note: exposure

variableRole: Use extension:variableRoleCode instead. (EvidenceVariableRole#exposure "exposure")

observed: EvidenceVariable/172481: GroupAssignment: Roux-en-Y gastric bypass surgery vs. Lifestyle-intensive medical management intervention alone "GroupAssignment_Roux_en_Y_gastric_bypass_surgery_vs_Lifestyle_intensive_medical_management_intervention_alone"

variableDefinition

VariableDefinitionVariableRoleCode: outcome

description: HbA1c at 24 months

note: outcome

variableRole: Use extension:variableRoleCode instead. (EvidenceVariableRole#measuredVariable "measured variable")

observed: EvidenceVariable/173246: OutcomeVariable: HbA1c at 24 months "OutcomeVariable_HbA1c_at_24_months"

synthesisType: not applicable (StatisticSynthesisType#NotApplicable)

studyDesign: randomized assignment (Scientific Evidence Code System (SEVCO) -- EXAMPLE VERSION for EBMonFHIR Implementation Guide#SEVCO:01003)

statistic

description: mean difference -1.90% (95% CI -2.78% to -1.02%)

note: Mean HbA1c at 24 months in Ikramuddin 2015 was 6.5% in Surgery group (n = 56) and 8.4% in Medical/Lifestyle group (n = 54)

statisticType: Mean Difference (StatisticStatisticType#0000457)

quantity: -1.9 % (Details: UCUM code % = '%')

SampleSizes

-NumberOfParticipantsKnownDataCount
*110110

AttributeEstimates

-DescriptionTypeLevelRange
*95% CI -2.78% to -1.02%Confidence interval (StatisticAttribute Estimate Type#C53324)0.95-2.78--1.02 %