24598155 Long-term results of a phase II study with neoadjuvant docetaxel chemotherapy and complete androgen blockade in locally advanced and high-risk prostate cancer. - Evidence Based Medicine on FHIR Implementation Guide v1.0.0-ballot

This page is part of the Evidence Based Medicine on FHIR Implementation Guide (v1.0.0-ballot: STU1 Ballot 1) based on FHIR (HL7® FHIR® Standard) v5.0.0. . For a full list of available versions, see the Directory of published versions

Example Citation: 24598155 Long-term results of a phase II study with neoadjuvant docetaxel chemotherapy and complete androgen blockade in locally advanced and high-risk prostate cancer.

Active as of 2023-12-17

Generated Narrative: Citation

Resource Citation "179624" Version "1" Updated "2023-11-26 22:35:20+0000"

StructureDefinition Work Group: cds

url: https://fevir.net/resources/Citation/179624

identifier: FEvIR Object Identifier: 179624, id: 24598155

version: 1.0.0-ballot

title: 24598155 Long-term results of a phase II study with neoadjuvant docetaxel chemotherapy and complete androgen blockade in locally advanced and high-risk prostate cancer.

status: active

date: 2023-12-17 16:55:23+0000

publisher: HL7 International / Clinical Decision Support

contact: HL7 International / Clinical Decision Support: http://www.hl7.org/Special/committees/dss

description: This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide.

UseContexts

Code

Value[x]

FEvIR Platform Use (Details: http://hl7.org/fhir/citation-classification-type code fevir-platform-use = 'FEvIR Platform Use', stated as 'FEvIR Platform Use')

Medline Base (Citation Artifact Classifier#medline-base)

jurisdiction: World (m49.htm#001)

copyright: https://creativecommons.org/licenses/by-nc-sa/4.0/

approvalDate: 2015-01-02

lastReviewDate: 2021-10-21

author: Computable Publishing®: MEDLINE-to-FEvIR Converter:

classification
type: Citation Source (Citation Classification Type#citation-source)
classifier: MEDLINE ()

classification
type: MEDLINE Citation Owner (Citation Classification Type#medline-owner)
classifier: National Library of Medicine, Index Section (elements_descriptions.html#owner_value#NLM)

currentState: Medline Citation Status of Medline (Citation Status Type#medline-medline), PubMed PublicationStatus of epublish (Citation Status Type#pubmed-publication-status-epublish)

statusDate
activity: PubMed Pubstatus of Received (Citation Status Type#pubmed-pubstatus-received)
period: ?? --> 2013-12-27

statusDate
activity: PubMed Pubstatus of Accepted (Citation Status Type#pubmed-pubstatus-accepted)
period: ?? --> 2014-02-25

statusDate
activity: PubMed Pubstatus of Entrez (Citation Status Type#pubmed-pubstatus-entrez)
period: ?? --> 2014-03-07 06:00:00+0000

statusDate
activity: PubMed Pubstatus of Pubmed (Citation Status Type#pubmed-pubstatus-pubmed)
period: ?? --> 2014-03-07 06:00:00+0000

statusDate
activity: PubMed Pubstatus of Medline (Citation Status Type#pubmed-pubstatus-medline)
period: ?? --> 2015-01-03 06:00:00+0000

citedArtifact
identifier: id: 24598155, id: PMC3974001, id: 10.1186/1756-8722-7-20, pii: 1756-8722-7-20
Titles
- Type Language Text
* Primary title (Title Type#primary) English (Tags for the Identification of Languages#en) Long-term results of a phase II study with neoadjuvant docetaxel chemotherapy and complete androgen blockade in locally advanced and high-risk prostate cancer.
Abstracts
- Text
* **BACKGROUND:** Patients with locally advanced and high-risk prostate cancer (LAPC) are prone to experience biochemical recurrence despite radical prostatectomy (RP). We evaluated feasibility, safety and activity of a neoadjuvant chemohormonal therapy (NCHT) with 3-weekly full dose docetaxel and complete androgen blockade (CAB) in locally advanced and high-risk prostate cancer patients (LAPC) undergoing RP. **METHODS:** Patients (n = 30) were selected by Kattans' preoperative score and received trimestral buserelin 9,45 mg, bicalutamide 50 mg/day and 3 cycles docetaxel (75 mg/m²) followed by RP. Primary endpoints were biochemical (PSA) and local downstaging. Secondary endpoints included toxicity and operability assessments, pathological complete response (pCR), time to PSA progression, 5-year biochemical recurrence free survival (bRFS) and overall survival (OS). **RESULTS:** Median baseline PSA was 25.8 ng/ml (2.1-293), and the predicted probability of 5-year bRFS was 10% (0-55). NCHT induced PSA-reduction was 97.3% (81.3-99.9%; p < 0.001) and post-RP 96.7% of patients were therapy responders, with undetectable PSA-values. Post- vs. pretreatment MRI indicated a median tumor volume reduction of 46.4% (-31.3-82.8; p < 0.001). A pathological downstaging was observed in 48.3%. Severe hematologic toxicities (≥CTC3) were frequent with 53.8% leucopenia, 90% neutropenia and 13.3% febrile neutropenia. RP was performed in all patients. While resectability was hindered in 26.7%, continence was achieved in 96.7%. Pathologic analyses revealed no pCR. Lymph node- and extracapsular involvement was observed in 36.7% and 56.7% with 33.3% positive surgical margins. After a median of 48.6 (19.9-87.8) months, 55.2% of therapy responders experienced PSA-recurrence. The estimated median time to PSA-progression was 38.6 months (95%CI 30.9-46.4) and 85.3 months (95%CI 39.3-131.3) for OS. The 5-year bRFS was improved to 40%, but limiting for interpretation adjuvant treatment was individualized. **CONCLUSIONS:** NCHT is feasible despite high hematotoxicity, with excellent functional results. Significant downstaging was observed without pCR. NCHT seems to improve the cohort adjusted 5-year bRFS, but clinical value needs further investigation in randomized trials.
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: Kattan MW, Eastham JA, Stapleton AMF, Wheeler TM, Scardino PT. A preoperative nomogram for disease recurrence following radical prostatectomy for prostate cancer. J Natl Cancer Inst. 1998;90:766–771. doi: 10.1093/jnci/90.10.766.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/9605647/
resourceReference: id: 9605647
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: D’Amico AV, Whittington R, Malkowicz SB, Schultz D, Blank K, Broderick GA, Tomaszewski JE, Renshaw AA, Kaplan I, Beard CJ, Wein A. Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer. JAMA. 1998;280(11):969–974. doi: 10.1001/jama.280.11.969.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/9749478/
resourceReference: id: 9749478
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: Sonpavde G, Sternberg CN. Neoadjuvant systemic therapy for urological malignancies. BJU Int. 2010;106(1):6–22.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/20553475/
resourceReference: id: 20553475
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: Bolla M, Collette L, Blank L, Warde P, Dubois JB, Mirimanoff RO, Storme G, Bernier J, Kuten A, Sternberg C, Mattelaer J, Lopez Torecilla J, Pfeffer JR, Lino Cutajar C, Zurlo A, Pierart M. Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): a phase III randomised trial. Lancet. 2002;360(9327):103–106. doi: 10.1016/S0140-6736(02)09408-4.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/12126818/
resourceReference: id: 12126818
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: Warde P, Mason M, Ding K, Kirkbride P, Brundage M, Cowan R, Gospodarowicz M, Sanders K, Kostashuk E, Swanson G, Barber J, Hiltz A, Parmar MK, Sathya J, Anderson J, Hayter C, Hetherington J, Sydes MR, Parulekar W, NCIC CTG. PR.3/MRC UK PR07 investigators. Combined androgen deprivation therapy and radiation therapy for locally advanced prostate cancer: a randomised, phase 3 trial. Lancet. 2011;378(9809):2104–2111. doi: 10.1016/S0140-6736(11)61095-7.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/22056152/
resourceReference: id: 22056152
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: Shelley MD, Kumar S, Wilt T, Staffurth J, Coles B, Mason MD. A systematic review and meta-analysis of randomised trials of neo-adjuvant hormone therapy for localised and locally advanced prostate carcinoma. Cancer Treat Rev. 2009;35(1):9–17. doi: 10.1016/j.ctrv.2008.08.002.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/18926640/
resourceReference: id: 18926640
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: Prayer-Galetti T, Sacco E, Pagano F, Gardiman M, Cisternino A, Betto G, Sperandio P. Long-term follow-up of a neoadjuvant chemohormonal taxane-based phase II trial before radical prostatectomy in patients with non-metastatic high-risk prostate cancer. BJU Int. 2007;100(2):274–280. doi: 10.1111/j.1464-410X.2007.06760.x.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/17355369/
resourceReference: id: 17355369
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: Petrylak DP, Tangen CM, Hussain MH, Lara PN Jr, Jones JA, Taplin ME, Burch PA, Berry D, Moinpour C, Kohli M, Benson MC, Small EJ, Raghavan D, Crawford ED. Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. N Engl J Med. 2004;351(15):1513–1520. doi: 10.1056/NEJMoa041318.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/15470214/
resourceReference: id: 15470214
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: Berthold DR, Pond GR, Soban F, de Wit R, Eisenberger M, Tannock IF. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer: updated survival in the TAX 327 study. J Clin Oncol. 2008;26(2):242–245. doi: 10.1200/JCO.2007.12.4008.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/18182665/
resourceReference: id: 18182665
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: Sartor AO. Progression of metastatic castrate-resistant prostate cancer: impact of therapeutic intervention in the post-docetaxel space. J Hematol Oncol. 2011;4:18. doi: 10.1186/1756-8722-4-18.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/21513551/
resourceReference: id: 21513551
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: Huang X, Chau CH, Figg WD. Challenges to improved therapeutics for metastatic castrate resistant prostate cancer: from recent successes and failures. J Hematol Oncol. 2012;5:35. doi: 10.1186/1756-8722-5-35.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/22747660/
resourceReference: id: 22747660
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: Dreicer R, Magi-Galluzzi C, Zhou M, Rothaermel J, Reuther A, Ulchaker J, Zippe C, Fergany A, Klein EA. Phase II trial of neoadjuvant docetaxel before radical prostatectomy for locally advanced prostate cancer. Urology. 2004;63(6):1138–1142. doi: 10.1016/j.urology.2004.01.040.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/15183967/
resourceReference: id: 15183967
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: Febbo PG, Richie JP, George DJ, Loda M, Manola J, Shankar S, Barnes AS, Tempany C, Catalona W, Kantoff PW, Oh WK. Neoadjuvant docetaxel before radical prostatectomy in patients with high-risk localized prostate cancer. Clin Cancer Res. 2005;11(14):5233–5240. doi: 10.1158/1078-0432.CCR-05-0299.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/16033841/
resourceReference: id: 16033841
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: Magi-Galluzzi C, Zhou M, Reuther AM, Dreicer R, Klein EA. Neoadjuvant docetaxel treatment for locally advanced prostate cancer: a clinicopathologic study. Cancer. 2007;110(6):1248–1254. doi: 10.1002/cncr.22897.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/17674353/
resourceReference: id: 17674353
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: Mellado B, Font A, Alcaraz A, Aparicio LA, Veiga FJ, Areal J, Gallardo E, Hannaoui N, Lorenzo JR, Sousa A, Fernandez PL, Gascon P. Phase II trial of short-term neoadjuvant docetaxel and complete androgen blockade in high-risk prostate cancer. Br J Cancer. 2009;101(8):1248–1252. doi: 10.1038/sj.bjc.6605320.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/19755998/
resourceReference: id: 19755998
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: Chi KN, Chin JL, Winquist E, Klotz L, Saad F, Gleave ME. Multicenter phase II study of combined neoadjuvant docetaxel and hormone therapy before radical prostatectomy for patients with high risk localized prostate cancer. J Urol. 2008;180(2):565–570. doi: 10.1016/j.juro.2008.04.012.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/18554663/
resourceReference: id: 18554663
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: Sella A, Zisman A, Kovel S, Yarom N, Leibovici D, Lindner A. Neoadjuvant chemohormonal therapy in poor-prognosis localized prostate cancer. Urology. 2008;71(2):323–327. doi: 10.1016/j.urology.2007.08.060.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/18308112/
resourceReference: id: 18308112
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: Narita S, Tsuchiya N, Kumazawa T, Maita S, Numakura K, Obara T, Tsuruta H, Saito M, Inoue T, Horikawa Y, Satoh S, Nanjyo H, Habuchi T. Short-term clinicopathological outcome of neoadjuvant chemohormonal therapy comprising complete androgen blockade, followed by treatment with docetaxel and estramustine phosphate before radical prostatectomy in Japanese patients with high-risk localized prostate cancer. World J Surg Oncol. 2012;10:1. doi: 10.1186/1477-7819-10-1.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/22214417/
resourceReference: id: 22214417
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: van der Kwast TH, Têtu B, Candas B, Gomez JL, Cusan L, Labrie F. Prolonged neoadjuvant combined androgen blockade leads to a further reduction of prostatic tumor volume: three versus six months of endocrine therapy. Urology. 1999;53(3):523–529. doi: 10.1016/S0090-4295(98)00542-1.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/10096378/
resourceReference: id: 10096378
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: Hu JC, Elkin EP, Pasta DJ, Lubeck DP, Kattan MW, Carroll PR, Litwin MS. Predicting quality of life after radical prostatectomy: results from CaPSURE. J Urol. 2004;171(2 Pt 1):703–708.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/14713791/
resourceReference: id: 14713791
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: Kim WY, Whang YE, Pruthi RS, Baggstrom MQ, Rathmell WK, Rosenman JG, Wallen EM, Goyal LK, Grigson G, Watkins C, Godley PA. Neoadjuvant docetaxel/estramustine prior to radical prostatectomy or external beam radiotherapy in high risk localized prostate cancer: a phase II trial. Urol Oncol. 2011;29(6):608–613. doi: 10.1016/j.urolonc.2009.09.012.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/20022268/
resourceReference: id: 20022268
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: Schulman CC, Debruyne FM, Forster G, Selvaggi FP, Zlotta AR, Witjes WP. 4-year follow-up results of a European prospective randomized study on neoadjuvant hormonal therapy prior to radical prostatectomy in T2-3N0M0 prostate cancer. European Study Group on Neoadjuvant Treatment of Prostate Cancer. Eur Urol. 2000;38(6):706–713. doi: 10.1159/000020366.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/11111188/
resourceReference: id: 11111188
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: Hussain M, Smith DC, El-Rayes BF, Du W, Vaishampayan U, Fontana J, Sakr W, Wood D. Neoadjuvant docetaxel and estramustine chemotherapy in high-risk/locallyadvanced prostate cancer. Urology. 2003;61(4):774–780. doi: 10.1016/S0090-4295(02)02519-0.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/12670564/
resourceReference: id: 12670564
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: Eastham JA, Kelly WK, Grossfeld GD, Small EJ. Cancer and Leukemia Group B (CALGB) 90203: a randomized phase 3 study of radical prostatectomy alone versus estramustine and docetaxel before radical prostatectomy for patients with high-risk localized disease. Urology. 2003;62(Suppl 1):55–62.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/14747042/
resourceReference: id: 14747042
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: D’Amico AV, Chang E, Garnick M, Kantoff P, Jiroutek M, Tempany CM. Assessment of prostate cancer volume using endorectal coil magnetic resonance imaging: a new predictor of tumor response to neoadjuvant androgen suppression therapy. Urology. 1998;51(2):287–292. doi: 10.1016/S0090-4295(97)00610-9.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/9495713/
resourceReference: id: 9495713
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: D’Amico AV, Halabi S, Tempany C, Titelbaum D, Philips GK, Loffredo M, McMahon E, Sanford B, Vogelzang NJ, Small EJ. Cancer and Leukemia Group B. Tumor volume changes on 1.5 tesla endorectal MRI during neoadjuvant androgen suppression therapy for higher-risk prostate cancer and recurrence in men treated using radiation therapy results of the phase II CALGB 9682 study. Int J Radiat Oncol Biol Phys. 2008;71(1):9–15. doi: 10.1016/j.ijrobp.2007.09.033.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/18037582/
resourceReference: id: 18037582
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: Vuky J, Porter C, Isacson C, Vaughan M, Kozlowski P, Picozzi V, Corman J. Phase II trial of neoadjuvant docetaxel and gefitinib followed by radical prostatectomy in patients with high-risk, locally advanced prostate cancer. Cancer. 2009;115(4):784–791. doi: 10.1002/cncr.24092.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/19130458/
resourceReference: id: 19130458
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: Mottet N, Bellmunt J, Bolla M, Joniau S, Mason M, Matveev V, Schmid HP, Van der Kwast T, Wiegel T, Zattoni F, Heidenreich A. EAU guidelines on prostate cancer. Part II: Treatment of advanced, relapsing, and castration-resistant prostate cancer. Eur Urol. 2011;59(4):572–583. doi: 10.1016/j.eururo.2011.01.025.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/21315502/
resourceReference: id: 21315502
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA. Sildenafil Study Group. Oral sildenafil in the treatment of erectile dysfunction. 1998. J Urol. 2002;167(2 Pt 2):1197–1203.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/11905901/
resourceReference: id: 11905901
relatesTo
type: cites
classifier: Journal Article (Citation Artifact Classifier#D016428)
citation: Bubley GJ, Carducci M, Dahut W, Dawson N, Daliani D, Eisenberger M, Figg WD, Freidlin B, Halabi S, Hudes G, Hussain M, Kaplan R, Myers C, Oh W, Petrylak DP, Reed E, Roth B, Sartor O, Scher H, Simons J, Sinibaldi V, Small EJ, Smith MR, Trump DL, Robin V, Wilding G. Eligibility and response guidelines for phase II clinical trials in androgen-independent prostate cancer: recommendations from the Prostate-Specific Antigen Working Group. J Clin Oncol. 1999;17(11):3461–3467.
Documents
- Url
* https://pubmed.ncbi.nlm.nih.gov/10550143/
resourceReference: id: 10550143
publicationForm
PublishedIns
- Type Identifier Title PublisherLocation
* Periodical (Published In Type#D020492) Electronic ISSN Type: 1756-8722, ISOAbbreviation: J Hematol Oncol, ISSN Linking: 1756-8722, Medline Title Abbreviation: J Hematol Oncol, NLM Unique ID: 101468937 Journal of hematology & oncology England
citedMedium: Internet (Cited Medium#internet)
volume: 7
articleDate: 2014-03-05
publicationDateText: 2014-Mar-05
language: English (Tags for the Identification of Languages#en)
pageString: 20
publicationForm
citedMedium: Internet without issue (Cited Medium#internet-without-issue)
articleDate: 2014-03-05
webLocation
classifier: Abstract (Artifact Url Classifier#abstract)
url: https://pubmed.ncbi.nlm.nih.gov/24598155/
webLocation
classifier: DOI Based (Artifact Url Classifier#doi-based)
url: https://doi.org/10.1186/1756-8722-7-20
classification
type: Publishing Model (Cited Artifact Classification Type#publishing-model)
classifier: Electronic (Citation Artifact Classifier#Electronic)
classification
type: Chemical (Cited Artifact Classification Type#chemical)
classifier: Androgen Antagonists (#D000726), Taxoids (#D043823), Docetaxel (chemical-substances#15H5577CQD; #D000077143)
classification
type: MeSH Heading (Cited Artifact Classification Type#mesh-heading)
artifactAssessment:

artifact: #
content
informationType: classifier
type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")
classifier: Aged (#D000368)
freeToShare: true
Components
- Type Classifier
* qualifier () is not a major topic ()
content
informationType: classifier
type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")
classifier: Androgen Antagonists (#D000726)
freeToShare: true
component
type: qualifier ()
classifier: is not a major topic ()
component
type: qualifier ()
classifier: therapeutic use (#Q000627)
component
content
informationType: classifier
type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")
classifier: Disease Progression (#D018450)
freeToShare: true
Components
- Type Classifier
* qualifier () is not a major topic ()
content
informationType: classifier
type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")
classifier: Docetaxel (#D000077143)
freeToShare: true
Components
- Type Classifier
* qualifier () is not a major topic ()
content
informationType: classifier
type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")
classifier: Humans (#D006801)
freeToShare: true
Components
- Type Classifier
* qualifier () is not a major topic ()
content
informationType: classifier
type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")
classifier: Male (#D008297)
freeToShare: true
Components
- Type Classifier
* qualifier () is not a major topic ()
content
informationType: classifier
type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")
classifier: Middle Aged (#D008875)
freeToShare: true
Components
- Type Classifier
* qualifier () is not a major topic ()
content
informationType: classifier
type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")
classifier: Neoadjuvant Therapy (#D020360)
freeToShare: true
Components
- Type Classifier
* qualifier () is not a major topic ()
content
informationType: classifier
type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")
classifier: Prostatic Neoplasms (#D011471)
freeToShare: true
component
type: qualifier ()
classifier: is not a major topic ()
component
type: qualifier ()
classifier: drug therapy (#Q000188)
component
component
type: qualifier ()
classifier: surgery (#Q000601)
component
content
informationType: classifier
type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")
classifier: Survival Analysis (#D016019)
freeToShare: true
Components
- Type Classifier
* qualifier () is not a major topic ()
content
informationType: classifier
type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")
classifier: Taxoids (#D043823)
freeToShare: true
component
type: qualifier ()
classifier: is not a major topic ()
component
type: qualifier ()
classifier: adverse effects (#Q000009)
component
component
type: qualifier ()
classifier: therapeutic use (#Q000627)
component
content
informationType: classifier
type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")
classifier: Treatment Outcome (#D016896)
freeToShare: true
Components
- Type Classifier
* qualifier () is not a major topic ()
classification
type: Publication Type (Cited Artifact Classification Type#publication-type)
classifier: Clinical Trial, Phase II (#D017427), Journal Article (#D016428)
classification
type: Knowledge Artifact Type (Cited Artifact Classification Type#knowledge-artifact-type)
classifier: Journal Article (Citation Artifact Classifier#D016428)
artifactAssessment: : Classifier added by Computable Publishing LLC
classification
type: Citation Subset (Cited Artifact Classification Type#citation-subset)
classifier: IM (elements_descriptions.html#citationsubset#IM)
contributorship
complete: true
entry
contributor:

name: Mark Thalgott
forenameInitials: M
affiliation: : Department of Urology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str, 22, Munich 81675, Germany. mark.thalgott@lrz.tum.de.
entry
contributor:

name: Thomas Horn
forenameInitials: T
entry
contributor:

name: Matthias M Heck
forenameInitials: MM
entry
contributor:

name: Tobias Maurer
forenameInitials: T
entry
contributor:

name: Matthias Eiber
forenameInitials: M
entry
contributor:

name: Margitta Retz
forenameInitials: M
entry
contributor:

name: Michael Autenrieth
forenameInitials: M
entry
contributor:

name: Kathleen Herkommer
forenameInitials: K
entry
contributor:

name: Bernd J Krause
forenameInitials: BJ
entry
contributor:

name: Jürgen E Gschwend
forenameInitials: JE
entry
contributor:

name: Uwe Treiber
forenameInitials: U
entry
contributor:

name: Hubert R Kübler
forenameInitials: HR

Generated Narrative: Practitioner #author0
name: Mark Thalgott

Generated Narrative: Practitioner #author1
name: Thomas Horn

Generated Narrative: Practitioner #author2
name: Matthias M Heck

Generated Narrative: Practitioner #author3
name: Tobias Maurer

Generated Narrative: Practitioner #author4
name: Matthias Eiber

Generated Narrative: Practitioner #author5
name: Margitta Retz

Generated Narrative: Practitioner #author6
name: Michael Autenrieth

Generated Narrative: Practitioner #author7
name: Kathleen Herkommer

Generated Narrative: Practitioner #author8
name: Bernd J Krause

Generated Narrative: Practitioner #author9
name: Jürgen E Gschwend

Generated Narrative: Practitioner #author10
name: Uwe Treiber

Generated Narrative: Practitioner #author11
name: Hubert R Kübler

Generated Narrative: ArtifactAssessment #meshHeading0
artifact: #
content
informationType: classifier
type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")
classifier: Aged (#D000368)
freeToShare: true
Components
- Type Classifier
* qualifier () is not a major topic ()
content
informationType: classifier
type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")
classifier: Androgen Antagonists (#D000726)
freeToShare: true
component
type: qualifier ()
classifier: is not a major topic ()
component
type: qualifier ()
classifier: therapeutic use (#Q000627)
component
content
informationType: classifier
type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")
classifier: Disease Progression (#D018450)
freeToShare: true
Components
- Type Classifier
* qualifier () is not a major topic ()
content
informationType: classifier
type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")
classifier: Docetaxel (#D000077143)
freeToShare: true
Components
- Type Classifier
* qualifier () is not a major topic ()
content
informationType: classifier
type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")
classifier: Humans (#D006801)
freeToShare: true
Components
- Type Classifier
* qualifier () is not a major topic ()
content
informationType: classifier
type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")
classifier: Male (#D008297)
freeToShare: true
Components
- Type Classifier
* qualifier () is not a major topic ()
content
informationType: classifier
type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")
classifier: Middle Aged (#D008875)
freeToShare: true
Components
- Type Classifier
* qualifier () is not a major topic ()
content
informationType: classifier
type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")
classifier: Neoadjuvant Therapy (#D020360)
freeToShare: true
Components
- Type Classifier
* qualifier () is not a major topic ()
content
informationType: classifier
type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")
classifier: Prostatic Neoplasms (#D011471)
freeToShare: true
component
type: qualifier ()
classifier: is not a major topic ()
component
type: qualifier ()
classifier: drug therapy (#Q000188)
component
component
type: qualifier ()
classifier: surgery (#Q000601)
component
content
informationType: classifier
type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")
classifier: Survival Analysis (#D016019)
freeToShare: true
Components
- Type Classifier
* qualifier () is not a major topic ()
content
informationType: classifier
type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")
classifier: Taxoids (#D043823)
freeToShare: true
component
type: qualifier ()
classifier: is not a major topic ()
component
type: qualifier ()
classifier: adverse effects (#Q000009)
component
component
type: qualifier ()
classifier: therapeutic use (#Q000627)
component
content
informationType: classifier
type: components (if present) include qualifier codings (Cited Artifact Classification Type#mesh-heading "MeSH heading")
classifier: Treatment Outcome (#D016896)
freeToShare: true
Components
- Type Classifier
* qualifier () is not a major topic ()