DatasetCitation: Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and is Associated with Worse Outcomes - TTL Representation - Evidence Based Medicine on FHIR Implementation Guide v1.0.0-ballot

This page is part of the Evidence Based Medicine on FHIR Implementation Guide (v1.0.0-ballot: STU1 Ballot 1) based on FHIR (HL7® FHIR® Standard) v5.0.0. . For a full list of available versions, see the Directory of published versions
: DatasetCitation: Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and is Associated with Worse Outcomes - TTL Representation

Active as of 2023-12-17
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@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

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fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Citation</b><a name=\"179559\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Citation &quot;179559&quot; Version &quot;5&quot; Updated &quot;2023-12-02 22:30:09+0000&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-dataset-citation.html\">DatasetCitation</a></p></div><p><b>StructureDefinition Work Group</b>: cds</p><p><b>url</b>: <code>https://fevir.net/resources/Citation/179559</code></p><p><b>identifier</b>: FEvIR Object Identifier: 179559</p><p><b>version</b>: 1.0.0-ballot</p><p><b>title</b>: DatasetCitation: Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and is Associated with Worse Outcomes</p><p><b>status</b>: active</p><p><b>date</b>: 2023-12-17 16:55:23+0000</p><p><b>publisher</b>: HL7 International / Clinical Decision Support</p><p><b>contact</b>: HL7 International / Clinical Decision Support: <a href=\"http://www.hl7.org/Special/committees/dss\">http://www.hl7.org/Special/committees/dss</a></p><p><b>description</b>: This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide.</p><p><b>jurisdiction</b>: World <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (m49.htm#001)</span></p><p><b>copyright</b>: https://creativecommons.org/licenses/by-nc-sa/4.0/</p><p><b>author</b>: Brian S. Alper: </p><h3>Summaries</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Style</b></td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td>Computable Publishing <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-summary-style.html\">Citation Summary Style</a>#comppub)</span></td><td>Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and is Associated with Worse Outcomes [Dataset]. Contributors:  Anish Thomas,  Lorinc S. Pongor,  Rajesh Kumar,  Parth Desai [Authors]. In: database of Genotypes and Phenotypes, Accession Number phs003190.v1.p1. Published October 16, 2023. Available at: https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs003190.v1.p1.</td></tr></table><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: dbGaP Study Accession: phs003190.v1.p1</p><h3>Titles</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Language</b></td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td>Primary title <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-title-type.html\">Title Type</a>#primary)</span></td><td>English <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-ietf3066.html\">Tags for the Identification of Languages</a>#en)</span></td><td>Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and is Associated with Worse Outcomes</td></tr></table><h3>Abstracts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Language</b></td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td>Study Description <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-179423.html\">Evidence Based Medicine on FHIR Implementation Guide Code System</a>#description &quot;Description&quot;)</span></td><td>English <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-ietf3066.html\">Tags for the Identification of Languages</a>#en)</span></td><td>Small-cell lung cancer (SCLC) is a very aggressive neuroendocrine lung cancer often associated with oncogenic MYC amplifications, which are known to drive SCLC heterogeneity marked by neuroendocrine (NE) and non-neuroendocrine (non-NE) cell states. The genetic mechanisms of MYC amplification and phenotypic plasticity between cell states is not known. Using data from cell-lines and a few patient-derived samples along with integrated whole-genome sequencing, long-range optical mapping, single-cell DNA sequencing, and fluorescence in situ hybridization, we have attempted to successfully characterize extrachromosomal DNA (ecDNA) as the primary source of MYC amplifications and driver fusions in SCLC.\n\nStudy Design:\nCross-Sectional\nStudy Type:\nObservational\nTotal number of consented subjects: 5</td></tr></table><blockquote><p><b>publicationForm</b></p><h3>PublishedIns</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Identifier</b></td><td><b>Title</b></td><td><b>Publisher</b></td><td><b>PublisherLocation</b></td></tr><tr><td style=\"display: none\">*</td><td>Database <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-published-in-type.html\">Published In Type</a>#D019991)</span></td><td>Abbreviation: dbGaP</td><td>database of Genotypes and Phenotypes</td><td><span>: NLM</span></td><td>Bethesda, MD, USA</td></tr></table><p><b>citedMedium</b>: Internet <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-medium.html\">Cited Medium</a>#internet)</span></p><p><b>articleDate</b>: 2023-10-16</p><p><b>accessionNumber</b>: phs003190.v1.p1</p><p><b>pageCount</b>: Total number of consented subjects: 5</p><p><b>copyright</b>: Data access provided by: dbGaP Authorized Access. For publicly available data (public ftp), Connect to the public download site. The site contains release notes and manifests. 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Pongor </p></blockquote><p><b>affiliation</b>: <span>: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA</span></p><p><b>contributionType</b>: Co-Investigator <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-179423.html\">Evidence Based Medicine on FHIR Implementation Guide Code System</a>#co-investigator)</span></p><p><b>role</b>: Author/Creator <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-contributor-role.html\">Contributor Role</a>#author)</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"contributor2\"> </a></p><blockquote><p/><p><a name=\"contributor2\"> </a></p><p><b>name</b>: Rajesh Kumar </p></blockquote><p><b>affiliation</b>: <span>: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA</span></p><p><b>contributionType</b>: Co-Investigator <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-179423.html\">Evidence Based Medicine on FHIR Implementation Guide Code System</a>#co-investigator)</span></p><p><b>role</b>: Author/Creator <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-contributor-role.html\">Contributor Role</a>#author)</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"contributor3\"> </a></p><blockquote><p/><p><a name=\"contributor3\"> </a></p><p><b>name</b>: Parth Desai </p></blockquote><p><b>affiliation</b>: <span>: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA</span></p><p><b>contributionType</b>: Co-Investigator <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-179423.html\">Evidence Based Medicine on FHIR Implementation Guide Code System</a>#co-investigator)</span></p><p><b>role</b>: Author/Creator <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-contributor-role.html\">Contributor Role</a>#author)</span></p></blockquote></blockquote></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #contributor0</b><a name=\"contributor0\"> </a></p><p><b>name</b>: Anish Thomas </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #contributor1</b><a name=\"contributor1\"> </a></p><p><b>name</b>: Lorinc S. 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fhir:display [ fhir:v "Dataset" ]         ] )       ] )     ] [
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        ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "study-design" ] ;
fhir:display [ fhir:v "Study Design" ]         ] ) ;
fhir:text [ fhir:v "Study Design" ]       ] ;
      ( fhir:classifier [
        ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/181513"^^xsd:anyURI ] ;
fhir:code [ fhir:v "SEVCO:01027" ] ;
fhir:display [ fhir:v "Cross sectional data collection" ]         ] ) ;
fhir:text [ fhir:v "Cross-Sectional" ]       ] [
        ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/181513"^^xsd:anyURI ] ;
fhir:code [ fhir:v "SEVCO:01002" ] ;
fhir:display [ fhir:v "observational research" ]         ] ) ;
fhir:text [ fhir:v "Observational Research" ]       ] )     ] [
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "defined-in-text" ] ;
fhir:display [ fhir:v "Defined in text" ]         ] ) ;
fhir:text [ fhir:v "Primary Phenotype" ]       ] ;
      ( fhir:classifier [
        ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "defined-in-text" ] ;
fhir:display [ fhir:v "Defined in text" ]         ] ) ;
fhir:text [ fhir:v "Small Cell Lung Carcinoma" ]       ] )     ] ) ;
fhir:contributorship [
fhir:complete [ fhir:v "true"^^xsd:boolean ] ;
      ( fhir:entry [
fhir:contributor [
fhir:reference [ fhir:v "#contributor0" ] ;
fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ]         ] ;
        ( fhir:affiliation [
fhir:display [ fhir:v "Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA" ]         ] ) ;
        ( fhir:contributionType [
          ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "principal-investigator" ] ;
fhir:display [ fhir:v "Principal Investigator" ]           ] ) ;
fhir:text [ fhir:v "Principal Investigator" ]         ] ) ;
fhir:role [
          ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/contributor-role"^^xsd:anyURI ] ;
fhir:code [ fhir:v "author" ] ;
fhir:display [ fhir:v "Author/Creator" ]           ] )         ]       ] [
fhir:contributor [
fhir:reference [ fhir:v "#contributor1" ] ;
fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ]         ] ;
        ( fhir:affiliation [
fhir:display [ fhir:v "Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA" ]         ] ) ;
        ( fhir:contributionType [
          ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "co-investigator" ] ;
fhir:display [ fhir:v "Co-Investigator" ]           ] ) ;
fhir:text [ fhir:v "Co-Investigator" ]         ] ) ;
fhir:role [
          ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/contributor-role"^^xsd:anyURI ] ;
fhir:code [ fhir:v "author" ] ;
fhir:display [ fhir:v "Author/Creator" ]           ] )         ]       ] [
fhir:contributor [
fhir:reference [ fhir:v "#contributor2" ] ;
fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ]         ] ;
        ( fhir:affiliation [
fhir:display [ fhir:v "Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA" ]         ] ) ;
        ( fhir:contributionType [
          ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "co-investigator" ] ;
fhir:display [ fhir:v "Co-Investigator" ]           ] ) ;
fhir:text [ fhir:v "Co-Investigator" ]         ] ) ;
fhir:role [
          ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/contributor-role"^^xsd:anyURI ] ;
fhir:code [ fhir:v "author" ] ;
fhir:display [ fhir:v "Author/Creator" ]           ] )         ]       ] [
fhir:contributor [
fhir:reference [ fhir:v "#contributor3" ] ;
fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ]         ] ;
        ( fhir:affiliation [
fhir:display [ fhir:v "Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA" ]         ] ) ;
        ( fhir:contributionType [
          ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "co-investigator" ] ;
fhir:display [ fhir:v "Co-Investigator" ]           ] ) ;
fhir:text [ fhir:v "Co-Investigator" ]         ] ) ;
fhir:role [
          ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/contributor-role"^^xsd:anyURI ] ;
fhir:code [ fhir:v "author" ] ;
fhir:display [ fhir:v "Author/Creator" ]           ] )         ]       ] )     ]
  ] . #