Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot - ballot
Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot - ballot
This page is part of the Evidence Based Medicine on FHIR Implementation Guide (v1.0.0-ballot: STU1 Ballot 1) based on FHIR (HL7® FHIR® Standard) v5.0.0. . For a full list of available versions, see the Directory of published versions
| Active as of 2023-12-17 |
@prefix fhir: <http://hl7.org/fhir/> . @prefix owl: <http://www.w3.org/2002/07/owl#> . @prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> . @prefix xsd: <http://www.w3.org/2001/XMLSchema#> . # - resource ------------------------------------------------------------------- a fhir:Citation ; fhir:nodeRole fhir:treeRoot ; fhir:id [ fhir:v "153881"] ; # fhir:meta [ fhir:versionId [ fhir:v "1" ] ; fhir:lastUpdated [ fhir:v "2023-08-10T21:44:41.656Z"^^xsd:dateTime ] ] ; # fhir:text [ fhir:status [ fhir:v "extensions" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Citation</b><a name=\"153881\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Citation "153881" Version "1" Updated "2023-08-10 21:44:41+0000" </p></div><p><b>StructureDefinition Work Group</b>: cds</p><p><b>url</b>: <code>https://fevir.net/resources/Citation/153881</code></p><p><b>identifier</b>: FEvIR Object Identifier: 153881, id: 35378077</p><p><b>version</b>: 1.0.0-ballot</p><p><b>title</b>: Delany-Moretlwe 2022 clinical trial</p><p><b>status</b>: active</p><p><b>date</b>: 2023-12-17 16:55:23+0000</p><p><b>publisher</b>: HL7 International / Clinical Decision Support</p><p><b>contact</b>: HL7 International / Clinical Decision Support: <a href=\"http://www.hl7.org/Special/committees/dss\">http://www.hl7.org/Special/committees/dss</a></p><p><b>description</b>: This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide.</p><h3>UseContexts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>FEvIR Platform Use (Details: http://hl7.org/fhir/citation-classification-type code fevir-platform-use = 'FEvIR Platform Use', stated as 'FEvIR Platform Use')</td><td>Project Specific <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-artifact-classifier.html\">Citation Artifact Classifier</a>#project-specific)</span></td></tr></table><p><b>jurisdiction</b>: World <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (m49.htm#001)</span></p><p><b>copyright</b>: https://creativecommons.org/licenses/by-nc-sa/4.0/</p><p><b>approvalDate</b>: 2022-05-10</p><p><b>lastReviewDate</b>: 2023-03-17</p><p><b>author</b>: Brian S. Alper: , Computable Publishing®: MEDLINE-to-FEvIR Converter: </p><blockquote><p><b>classification</b></p><p><b>type</b>: Citation Source <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-classification-type.html\">Citation Classification Type</a>#citation-source)</span></p><p><b>classifier</b>: MEDLINE <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: MEDLINE Citation Owner <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-classification-type.html\">Citation Classification Type</a>#medline-owner)</span></p><p><b>classifier</b>: National Library of Medicine, Index Section <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (elements_descriptions.html#owner_value#NLM)</span></p></blockquote><p><b>currentState</b>: Medline Citation Status of Medline <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-status-type.html\">Citation Status Type</a>#medline-medline)</span>, PubMed PublicationStatus of ppublish <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-status-type.html\">Citation Status Type</a>#pubmed-publication-status-ppublish)</span></p><blockquote><p><b>statusDate</b></p><p><b>activity</b>: PubMed Pubstatus of Received <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-status-type.html\">Citation Status Type</a>#pubmed-pubstatus-received)</span></p><p><b>period</b>: ?? --> 2022-02-27</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: PubMed Pubstatus of Revised <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-status-type.html\">Citation Status Type</a>#pubmed-pubstatus-revised)</span></p><p><b>period</b>: ?? --> 2022-03-12</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: PubMed Pubstatus of Accepted <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-status-type.html\">Citation Status Type</a>#pubmed-pubstatus-accepted)</span></p><p><b>period</b>: ?? --> 2022-03-14</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: PubMed Pubstatus of Pubmed <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-status-type.html\">Citation Status Type</a>#pubmed-pubstatus-pubmed)</span></p><p><b>period</b>: ?? --> 2022-04-05 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: PubMed Pubstatus of Medline <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-status-type.html\">Citation Status Type</a>#pubmed-pubstatus-medline)</span></p><p><b>period</b>: ?? --> 2022-05-11 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: PubMed Pubstatus of Entrez <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-status-type.html\">Citation Status Type</a>#pubmed-pubstatus-entrez)</span></p><p><b>period</b>: ?? --> 2022-04-04 20:10:00+0000</p></blockquote><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: id: 35378077, id: PMC9077443, id: 10.1016/S0140-6736(22)00538-4, pii: S0140-6736(22)00538-4</p><p><b>relatedIdentifier</b>: id: NCT03164564</p><h3>Titles</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Language</b></td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td>Primary title <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-title-type.html\">Title Type</a>#primary)</span></td><td>English <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-ietf3066.html\">Tags for the Identification of Languages</a>#en)</span></td><td>Cabotegravir for the prevention of HIV-1 in women: results from HPTN 084, a phase 3, randomised clinical trial.</td></tr></table><h3>Abstracts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Text</b></td><td><b>Copyright</b></td></tr><tr><td style=\"display: none\">*</td><td>**BACKGROUND:** Oral pre-exposure prophylaxis has been introduced in more than 70 countries, including many in sub-Saharan Africa, but women experience considerable barriers to daily pill-taking, such as stigma, judgement, and the fear of violence. Safe and effective long-acting agents for HIV prevention are needed for women. We aimed to evaluate the safety and efficacy of injectable cabotegravir compared with daily oral tenofovir diphosphate plus emtricitabine (TDF-FTC) for HIV prevention in HIV-uninfected women.\n**METHODS:** HPTN 084 was a phase 3, randomised, double-blind, double-dummy, active-controlled, superiority trial in 20 clinical research sites in seven countries in sub-Saharan Africa. Participants were eligible for enrolment if they were assigned female sex at birth, were aged 18-45 years, reported at least two episodes of vaginal intercourse in the previous 30 days, were at risk of HIV infection based on an HIV risk score, and agreed to use a long-acting reversible contraceptive method. Participants were randomly assigned (1:1) to either active cabotegravir with TDF-FTC placebo (cabotegravir group) or active TDF-FTC with cabotegravir placebo (TDF-FTC group). Study staff and participants were masked to study group allocation, with the exception of the site pharmacist who was responsible for study product preparation. Participants were prescribed 5 weeks of daily oral product followed by intramuscular injections every 8 weeks after an initial 4-week interval load, alongside daily oral pills. Participants who discontinued injections were offered open-label daily TDF-FTC for 48 weeks. The primary endpoints of the study were incident HIV infection in the intention-to-treat population, and clinical and laboratory events that were grade 2 or higher in all women who had received at least one dose of study product. This study is registered with ClinicalTrials.gov, NCT03164564.\n**FINDINGS:** From Nov 27, 2017, to Nov 4, 2020, we enrolled 3224 participants (1614 in the cabotegravir group and 1610 in the TDF-FTC group). Median age was 25 years (IQR 22-30); 1755 (54·7%) of 3209 had two or more partners in the preceding month. 40 incident infections were observed over 3898 person-years (HIV incidence 1·0% [95% CI 0·73-1·40]); four in the cabotegravir group (HIV incidence 0·2 cases per 100 person-years [0·06-0·52]) and 36 in the TDF-FTC group (1·85 cases per 100 person-years [1·3-2·57]; hazard ratio 0·12 [0·05-0·31]; p&lt;0·0001; risk difference -1·6% [-1·0% to -2·3%]. In a random subset of 405 TDF-FTC participants, 812 (42·1%) of 1929 plasma samples had tenofovir concentrations consistent with daily use. Injection coverage was 93% of the total number of person-years. Adverse event rates were similar across both groups, apart from injection site reactions, which were more frequent in the cabotegravir group than in the TDF-FTC group (577 [38·0%] of 1519 vs 162 [10·7%] of 1516]) but did not result in injection discontinuation. Confirmed pregnancy incidence was 1·3 per 100 person-years (0·9-1·7); no congenital birth anomalies were reported.\n**INTERPRETATION:** Although both products for HIV prevention were generally safe, well tolerated, and effective, cabotegravir was superior to TDF-FTC in preventing HIV infection in women.\n**FUNDING:** National Institute of Allergy and Infectious Diseases, ViiV Healthcare, and the Bill &amp; Melinda Gates Foundation. Additional support was provided through the National Institute of Mental Health, the National Institute on Drug Abuse, and the Eunice Kennedy Shriver National Institute of Child Health and Human Development. ViiV Healthcare and Gilead Sciences provided pharmaceutical support.</td><td>Copyright © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.</td></tr></table><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>citation</b>: UNAIDS Confronting inequalities: lessons for pandemic responses from 40 years of AIDS. July 14, 2021. https://www.unaids.org/en/resources/documents/2021/2021-global-aids-update-slideset</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>citation</b>: WHO . World Health Organization; Geneva: 2015. Policy brief: pre-exposure prophylaxis (PrEP): WHO expands recommendation on oral pre-exposure prophylaxis of HIV infection (PrEP)</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: Journal Article <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-artifact-classifier.html\">Citation Artifact Classifier</a>#D016428)</span></p><p><b>citation</b>: Celum CL, Delany-Moretlwe S, Baeten JM, et al. HIV pre-exposure prophylaxis for adolescent girls and young women in Africa: from efficacy trials to delivery. J Int AIDS Soc. 2019;22(suppl 4)</p><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/31328444/\">https://pubmed.ncbi.nlm.nih.gov/31328444/</a></td></tr></table><p><b>resourceReference</b>: <span>id: 31328444</span></p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: Journal Article <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-artifact-classifier.html\">Citation Artifact Classifier</a>#D016428)</span></p><p><b>citation</b>: Velloza J, Khoza N, Scorgie F, et al. The influence of HIV-related stigma on PrEP disclosure and adherence among adolescent girls and young women in HPTN 082: a qualitative study. J Int AIDS Soc. 2020;23</p><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/32144874/\">https://pubmed.ncbi.nlm.nih.gov/32144874/</a></td></tr></table><p><b>resourceReference</b>: <span>id: 32144874</span></p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: Journal Article <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-artifact-classifier.html\">Citation Artifact Classifier</a>#D016428)</span></p><p><b>citation</b>: Cottrell ML, Yang KH, Prince HM, et al. A translational pharmacology approach to predicting outcomes of preexposure prophylaxis against HIV in men and women using tenofovir disoproxil fumarate with or without emtricitabine. J Infect Dis. 2016;214:55–64.</p><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/26917574/\">https://pubmed.ncbi.nlm.nih.gov/26917574/</a></td></tr></table><p><b>resourceReference</b>: <span>id: 26917574</span></p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: Journal Article <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-artifact-classifier.html\">Citation Artifact Classifier</a>#D016428)</span></p><p><b>citation</b>: Andrews CD, Yueh YL, Spreen WR, et al. A long-acting integrase inhibitor protects female macaques from repeated high-dose intravaginal SHIV challenge. Sci Transl Med. 2015;7</p><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/25589630/\">https://pubmed.ncbi.nlm.nih.gov/25589630/</a></td></tr></table><p><b>resourceReference</b>: <span>id: 25589630</span></p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: Journal Article <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-artifact-classifier.html\">Citation Artifact Classifier</a>#D016428)</span></p><p><b>citation</b>: Radzio J, Spreen W, Yueh YL, et al. The long-acting integrase inhibitor GSK744 protects macaques from repeated intravaginal SHIV challenge. Sci Transl Med. 2015;7</p><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/25589631/\">https://pubmed.ncbi.nlm.nih.gov/25589631/</a></td></tr></table><p><b>resourceReference</b>: <span>id: 25589631</span></p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: Journal Article <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-artifact-classifier.html\">Citation Artifact Classifier</a>#D016428)</span></p><p><b>citation</b>: Markowitz M, Frank I, Grant RM, et al. Safety and tolerability of long-acting cabotegravir injections in HIV-uninfected men (ECLAIR): a multicentre, double-blind, randomised, placebo-controlled, phase 2a trial. Lancet HIV. 2017;4:e331–e340.</p><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/28546090/\">https://pubmed.ncbi.nlm.nih.gov/28546090/</a></td></tr></table><p><b>resourceReference</b>: <span>id: 28546090</span></p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: Journal Article <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-artifact-classifier.html\">Citation Artifact Classifier</a>#D016428)</span></p><p><b>citation</b>: Landovitz RJ, Li S, Grinsztejn B, et al. Safety, tolerability, and pharmacokinetics of long-acting injectable cabotegravir in low-risk HIV-uninfected individuals: HPTN 077, a phase 2a randomized controlled trial. PLoS Med. 2018;15</p><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/30408115/\">https://pubmed.ncbi.nlm.nih.gov/30408115/</a></td></tr></table><p><b>resourceReference</b>: <span>id: 30408115</span></p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: Journal Article <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-artifact-classifier.html\">Citation Artifact Classifier</a>#D016428)</span></p><p><b>citation</b>: Landovitz RJ, Donnell D, Clement ME, et al. Cabotegravir for HIV prevention in cisgender men and transgender women. N Engl J Med. 2021;385:595–608.</p><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/34379922/\">https://pubmed.ncbi.nlm.nih.gov/34379922/</a></td></tr></table><p><b>resourceReference</b>: <span>id: 34379922</span></p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: Journal Article <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-artifact-classifier.html\">Citation Artifact Classifier</a>#D016428)</span></p><p><b>citation</b>: Balkus JE, Brown E, Palanee T, et al. An empiric HIV risk scoring tool to predict HIV-1 acquisition in African women. J Acquir Immune Defic Syndr. 2016;72:333–343.</p><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/26918545/\">https://pubmed.ncbi.nlm.nih.gov/26918545/</a></td></tr></table><p><b>resourceReference</b>: <span>id: 26918545</span></p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: Journal Article <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-artifact-classifier.html\">Citation Artifact Classifier</a>#D016428)</span></p><p><b>citation</b>: Eshleman SH, Fogel JM, Piwowar-Manning E, et al. Characterization of HIV infections in women who received injectable cabotegravir or tenofovir disoproxil fumarate/emtricitabine for HIV prevention: HPTN 084. J Infect Dis (in press).</p><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/35301540/\">https://pubmed.ncbi.nlm.nih.gov/35301540/</a></td></tr></table><p><b>resourceReference</b>: <span>id: 35301540</span></p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: Journal Article <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-artifact-classifier.html\">Citation Artifact Classifier</a>#D016428)</span></p><p><b>citation</b>: Castillo-Mancilla JR, Zheng JH, Rower JE, et al. Tenofovir, emtricitabine, and tenofovir diphosphate in dried blood spots for determining recent and cumulative drug exposure. AIDS Res Hum Retroviruses. 2013;29:384–390.</p><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/22935078/\">https://pubmed.ncbi.nlm.nih.gov/22935078/</a></td></tr></table><p><b>resourceReference</b>: <span>id: 22935078</span></p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: Journal Article <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-artifact-classifier.html\">Citation Artifact Classifier</a>#D016428)</span></p><p><b>citation</b>: Anderson PL, Liu AY, Castillo-Mancilla JR, et al. Intracellular tenofovir-diphosphate and emtricitabine-triphosphate in dried blood spots following directly observed therapy. Antimicrob Agents Chemother. 2017;62:e01710–e01717.</p><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/29038282/\">https://pubmed.ncbi.nlm.nih.gov/29038282/</a></td></tr></table><p><b>resourceReference</b>: <span>id: 29038282</span></p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: Journal Article <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-artifact-classifier.html\">Citation Artifact Classifier</a>#D016428)</span></p><p><b>citation</b>: Hendrix CW, Andrade A, Bumpus NN, et al. Dose frequency ranging pharmacokinetic study of tenofovir-emtricitabine after directly observed dosing in healthy volunteers to establish adherence benchmarks (HPTN 066) AIDS Res Hum Retroviruses. 2016;32:32–43.</p><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/26414912/\">https://pubmed.ncbi.nlm.nih.gov/26414912/</a></td></tr></table><p><b>resourceReference</b>: <span>id: 26414912</span></p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: Journal Article <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-artifact-classifier.html\">Citation Artifact Classifier</a>#D016428)</span></p><p><b>citation</b>: Donnell D, Baeten JM, Bumpus NN, et al. 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N Engl J Med. 2017;376:995–996.</p><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/28273023/\">https://pubmed.ncbi.nlm.nih.gov/28273023/</a></td></tr></table><p><b>resourceReference</b>: <span>id: 28273023</span></p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: Journal Article <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-artifact-classifier.html\">Citation Artifact Classifier</a>#D016428)</span></p><p><b>citation</b>: Venter WDF, Moorhouse M, Sokhela S, et al. Dolutegravir plus two different prodrugs of tenofovir to treat HIV. N Engl J Med. 2019;381:803–815.</p><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/31339677/\">https://pubmed.ncbi.nlm.nih.gov/31339677/</a></td></tr></table><p><b>resourceReference</b>: <span>id: 31339677</span></p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: Journal Article <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-artifact-classifier.html\">Citation Artifact Classifier</a>#D016428)</span></p><p><b>citation</b>: Landovitz RJ, Zangeneh SZ, Chau G, et al. Cabotegravir is not associated with weight gain in human immunodeficiency virus-uninfected individuals in HPTN 077. Clin Infect Dis. 2020;70:319–322.</p><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/31125395/\">https://pubmed.ncbi.nlm.nih.gov/31125395/</a></td></tr></table><p><b>resourceReference</b>: <span>id: 31125395</span></p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>citation</b>: Eshleman S, Fogel JM, Halvas EK, et al. 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margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-medium.html\">Cited Medium</a>#internet)</span></p><p><b>volume</b>: 399</p><p><b>issue</b>: 10337</p><p><b>articleDate</b>: 2022-05-07</p><p><b>publicationDateText</b>: 2022-May-07</p><p><b>language</b>: English <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-ietf3066.html\">Tags for the Identification of Languages</a>#en)</span></p><p><b>pageString</b>: 1779-1789</p></blockquote><blockquote><p><b>publicationForm</b></p><p><b>citedMedium</b>: Internet without issue <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-medium.html\">Cited Medium</a>#internet-without-issue)</span></p><p><b>articleDate</b>: 2022-04-01</p></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: Abstract <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-artifact-url-classifier.html\">Artifact Url Classifier</a>#abstract)</span></p><p><b>url</b>: <a href=\"https://pubmed.ncbi.nlm.nih.gov/35378077/\">https://pubmed.ncbi.nlm.nih.gov/35378077/</a></p></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: DOI Based <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-artifact-url-classifier.html\">Artifact Url Classifier</a>#doi-based)</span></p><p><b>url</b>: <a href=\"https://doi.org/10.1016/S0140-6736(22)00538-4\">https://doi.org/10.1016/S0140-6736(22)00538-4</a></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: Publishing Model <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#publishing-model)</span></p><p><b>classifier</b>: Print Electronic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-artifact-classifier.html\">Citation Artifact Classifier</a>#Print-Electronic)</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: Chemical <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#chemical)</span></p><p><b>classifier</b>: Anti-HIV Agents <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D019380)</span>, Diketopiperazines <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D054659)</span>, Pyridones <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D011728)</span>, Emtricitabine <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (chemical-substances#G70B4ETF4S; #D000068679)</span>, cabotegravir <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (chemical-substances#HMH0132Z1Q; #C584914)</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: MeSH Heading <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading)</span></p><p><b>artifactAssessment</b>: <a name=\"meshHeading0\"> </a></p><blockquote><p/><p><a name=\"meshHeading0\"> </a></p><p><b>artifact</b>: <a href=\"#\">#</a></p><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading "MeSH heading")</span></p><p><b>classifier</b>: Adult <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D000328)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading "MeSH heading")</span></p><p><b>classifier</b>: Anti-HIV Agents <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D019380)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is Major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading "MeSH heading")</span></p><p><b>classifier</b>: Child <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D002648)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading "MeSH heading")</span></p><p><b>classifier</b>: Diketopiperazines <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D054659)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading "MeSH heading")</span></p><p><b>classifier</b>: Emtricitabine <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D000068679)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: therapeutic use <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000627)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading "MeSH heading")</span></p><p><b>classifier</b>: Female <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D005260)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading "MeSH heading")</span></p><p><b>classifier</b>: HIV Infections <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D015658)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is Major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: chemically induced <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000139)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: epidemiology <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000453)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: prevention & control <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000517)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading "MeSH heading")</span></p><p><b>classifier</b>: HIV Seropositivity <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D006679)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is Major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: drug therapy <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000188)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading "MeSH heading")</span></p><p><b>classifier</b>: HIV-1 <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D015497)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is Major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading "MeSH heading")</span></p><p><b>classifier</b>: Humans <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D006801)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading "MeSH heading")</span></p><p><b>classifier</b>: Infant, Newborn <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D007231)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading "MeSH heading")</span></p><p><b>classifier</b>: Pregnancy <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D011247)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading "MeSH heading")</span></p><p><b>classifier</b>: Pyridones <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D011728)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: therapeutic use <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000627)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote></blockquote></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: Publication Type <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#publication-type)</span></p><p><b>classifier</b>: Clinical Trial, Phase III <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D017428)</span>, Journal Article <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D016428)</span>, Randomized Controlled Trial <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D016449)</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: Knowledge Artifact Type <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#knowledge-artifact-type)</span></p><p><b>classifier</b>: Journal Article <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-artifact-classifier.html\">Citation Artifact Classifier</a>#D016428)</span></p><p><b>artifactAssessment</b>: <span>: Classifier added by Computable Publishing LLC</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: Citation Subset <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#citation-subset)</span></p><p><b>classifier</b>: IM <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (elements_descriptions.html#citationsubset#IM)</span></p></blockquote><blockquote><p><b>contributorship</b></p><p><b>complete</b>: true</p><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author0\"> </a></p><blockquote><p/><p><a name=\"author0\"> </a></p><p><b>name</b>: Sinead Delany-Moretlwe </p></blockquote><p><b>forenameInitials</b>: S</p><p><b>affiliation</b>: <span>: Wits Reproductive Health and HIV Institute, University of the Witwatersrand, Johannesburg, South Africa. Electronic address: sdelany@wrhi.ac.za.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author1\"> </a></p><blockquote><p/><p><a name=\"author1\"> </a></p><p><b>name</b>: James P Hughes </p></blockquote><p><b>forenameInitials</b>: JP</p><p><b>affiliation</b>: <span>: Statistical Centre for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author2\"> </a></p><blockquote><p/><p><a name=\"author2\"> </a></p><p><b>name</b>: Peter Bock </p></blockquote><p><b>forenameInitials</b>: P</p><p><b>affiliation</b>: <span>: Desmond Tutu TB Centre, University of Stellenbosch, Stellenbosch, South Africa.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author3\"> </a></p><blockquote><p/><p><a name=\"author3\"> </a></p><p><b>name</b>: Samuel Gurrion Ouma </p></blockquote><p><b>forenameInitials</b>: SG</p><p><b>affiliation</b>: <span>: Kisumu Clinical Research Site, Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author4\"> </a></p><blockquote><p/><p><a name=\"author4\"> </a></p><p><b>name</b>: Portia Hunidzarira </p></blockquote><p><b>forenameInitials</b>: P</p><p><b>affiliation</b>: <span>: Clinical Trials Research Centre, University of Zimbabwe, Harare, Zimbabwe.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author5\"> </a></p><blockquote><p/><p><a name=\"author5\"> </a></p><p><b>name</b>: Dishiki Kalonji </p></blockquote><p><b>forenameInitials</b>: D</p><p><b>affiliation</b>: <span>: HIV and other Infectious Diseases Research Unit, South African Medical Research Council, Durban, South Africa.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author6\"> </a></p><blockquote><p/><p><a name=\"author6\"> </a></p><p><b>name</b>: Noel Kayange </p></blockquote><p><b>forenameInitials</b>: N</p><p><b>affiliation</b>: <span>: Blantyre Clinical Research Site, College of Medicine, University of Malawi, Blantyre, Malawi.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author7\"> </a></p><blockquote><p/><p><a name=\"author7\"> </a></p><p><b>name</b>: Joseph Makhema </p></blockquote><p><b>forenameInitials</b>: J</p><p><b>affiliation</b>: <span>: Botswana Harvard AIDS Institute Partnership (BHP), Gaborone, Botswana.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author8\"> </a></p><blockquote><p/><p><a name=\"author8\"> </a></p><p><b>name</b>: Patricia Mandima </p></blockquote><p><b>forenameInitials</b>: P</p><p><b>affiliation</b>: <span>: Clinical Trials Research Centre, University of Zimbabwe, Harare, Zimbabwe.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author9\"> </a></p><blockquote><p/><p><a name=\"author9\"> </a></p><p><b>name</b>: Carrie Mathew </p></blockquote><p><b>forenameInitials</b>: C</p><p><b>affiliation</b>: <span>: Wits Reproductive Health and HIV Institute, University of the Witwatersrand, Johannesburg, South Africa.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author10\"> </a></p><blockquote><p/><p><a name=\"author10\"> </a></p><p><b>name</b>: Elizabeth Spooner </p></blockquote><p><b>forenameInitials</b>: E</p><p><b>affiliation</b>: <span>: HIV and other Infectious Diseases Research Unit, South African Medical Research Council, Durban, South Africa.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author11\"> </a></p><blockquote><p/><p><a name=\"author11\"> </a></p><p><b>name</b>: Juliet Mpendo </p></blockquote><p><b>forenameInitials</b>: J</p><p><b>affiliation</b>: <span>: International AIDS Vaccine Initiative, Uganda Virus Research Institute, Entebbe, Uganda.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author12\"> </a></p><blockquote><p/><p><a name=\"author12\"> </a></p><p><b>name</b>: Pamela Mukwekwerere </p></blockquote><p><b>forenameInitials</b>: P</p><p><b>affiliation</b>: <span>: Clinical Trials Research Centre, University of Zimbabwe, Harare, Zimbabwe.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author13\"> </a></p><blockquote><p/><p><a name=\"author13\"> </a></p><p><b>name</b>: Nyaradzo Mgodi </p></blockquote><p><b>forenameInitials</b>: N</p><p><b>affiliation</b>: <span>: Clinical Trials Research Centre, University of Zimbabwe, Harare, Zimbabwe.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author14\"> </a></p><blockquote><p/><p><a name=\"author14\"> </a></p><p><b>name</b>: Patricia Nahirya Ntege </p></blockquote><p><b>forenameInitials</b>: PN</p><p><b>affiliation</b>: <span>: Baylor College of Medicine Children's Foundation Uganda, Kampala, Uganda.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author15\"> </a></p><blockquote><p/><p><a name=\"author15\"> </a></p><p><b>name</b>: Gonasagrie Nair </p></blockquote><p><b>forenameInitials</b>: G</p><p><b>affiliation</b>: <span>: Desmond Tutu Health Foundation, University of Cape Town, Cape Town, South Africa.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author16\"> </a></p><blockquote><p/><p><a name=\"author16\"> </a></p><p><b>name</b>: Clemensia Nakabiito </p></blockquote><p><b>forenameInitials</b>: C</p><p><b>affiliation</b>: <span>: Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author17\"> </a></p><blockquote><p/><p><a name=\"author17\"> </a></p><p><b>name</b>: Harriet Nuwagaba-Biribonwoha </p></blockquote><p><b>forenameInitials</b>: H</p><p><b>affiliation</b>: <span>: Eswatini Prevention Center, International Center for AIDS Care and Treatment Program at Columbia University Mailman School of Public Health, New York, NY, USA.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author18\"> </a></p><blockquote><p/><p><a name=\"author18\"> </a></p><p><b>name</b>: Ravindre Panchia </p></blockquote><p><b>forenameInitials</b>: R</p><p><b>affiliation</b>: <span>: Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author19\"> </a></p><blockquote><p/><p><a name=\"author19\"> </a></p><p><b>name</b>: Nishanta Singh </p></blockquote><p><b>forenameInitials</b>: N</p><p><b>affiliation</b>: <span>: HIV and other Infectious Diseases Research Unit, South African Medical Research Council, Durban, South Africa.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author20\"> </a></p><blockquote><p/><p><a name=\"author20\"> </a></p><p><b>name</b>: Bekezela Siziba </p></blockquote><p><b>forenameInitials</b>: B</p><p><b>affiliation</b>: <span>: Clinical Trials Research Centre, University of Zimbabwe, Harare, Zimbabwe.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author21\"> </a></p><blockquote><p/><p><a name=\"author21\"> </a></p><p><b>name</b>: Jennifer Farrior </p></blockquote><p><b>forenameInitials</b>: J</p><p><b>affiliation</b>: <span>: FHI 360, Durham, NC, USA.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author22\"> </a></p><blockquote><p/><p><a name=\"author22\"> </a></p><p><b>name</b>: Scott Rose </p></blockquote><p><b>forenameInitials</b>: S</p><p><b>affiliation</b>: <span>: FHI 360, Durham, NC, USA.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author23\"> </a></p><blockquote><p/><p><a name=\"author23\"> </a></p><p><b>name</b>: Peter L Anderson </p></blockquote><p><b>forenameInitials</b>: PL</p><p><b>affiliation</b>: <span>: Anschutz Medical Campus, University of Colorado, Aurora, CO, USA.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author24\"> </a></p><blockquote><p/><p><a name=\"author24\"> </a></p><p><b>name</b>: Susan H Eshleman </p></blockquote><p><b>forenameInitials</b>: SH</p><p><b>affiliation</b>: <span>: Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author25\"> </a></p><blockquote><p/><p><a name=\"author25\"> </a></p><p><b>name</b>: Mark A Marzinke </p></blockquote><p><b>forenameInitials</b>: MA</p><p><b>affiliation</b>: <span>: Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author26\"> </a></p><blockquote><p/><p><a name=\"author26\"> </a></p><p><b>name</b>: Craig W Hendrix </p></blockquote><p><b>forenameInitials</b>: CW</p><p><b>affiliation</b>: <span>: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author27\"> </a></p><blockquote><p/><p><a name=\"author27\"> </a></p><p><b>name</b>: Stephanie Beigel-Orme </p></blockquote><p><b>forenameInitials</b>: S</p><p><b>affiliation</b>: <span>: Statistical Centre for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author28\"> </a></p><blockquote><p/><p><a name=\"author28\"> </a></p><p><b>name</b>: Sybil Hosek </p></blockquote><p><b>forenameInitials</b>: S</p><p><b>affiliation</b>: <span>: Department of Psychiatry, Stroger Hospital of Cook County, Chicago, IL, USA.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author29\"> </a></p><blockquote><p/><p><a name=\"author29\"> </a></p><p><b>name</b>: Elizabeth Tolley </p></blockquote><p><b>forenameInitials</b>: E</p><p><b>affiliation</b>: <span>: FHI 360, Durham, NC, USA.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author30\"> </a></p><blockquote><p/><p><a name=\"author30\"> </a></p><p><b>name</b>: Nirupama Sista </p></blockquote><p><b>forenameInitials</b>: N</p><p><b>affiliation</b>: <span>: FHI 360, Durham, NC, USA.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author31\"> </a></p><blockquote><p/><p><a name=\"author31\"> </a></p><p><b>name</b>: Adeola Adeyeye </p></blockquote><p><b>forenameInitials</b>: A</p><p><b>affiliation</b>: <span>: Division of AIDS, National Institute of Allergy and Infectious Diseases, Rockville, MD, USA.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author32\"> </a></p><blockquote><p/><p><a name=\"author32\"> </a></p><p><b>name</b>: James F Rooney </p></blockquote><p><b>forenameInitials</b>: JF</p><p><b>affiliation</b>: <span>: Gilead Sciences, Foster City, CA, USA.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author33\"> </a></p><blockquote><p/><p><a name=\"author33\"> </a></p><p><b>name</b>: Alex Rinehart </p></blockquote><p><b>forenameInitials</b>: A</p><p><b>affiliation</b>: <span>: ViiV Healthcare, Durham, NC, USA.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author34\"> </a></p><blockquote><p/><p><a name=\"author34\"> </a></p><p><b>name</b>: William R Spreen </p></blockquote><p><b>forenameInitials</b>: WR</p><p><b>affiliation</b>: <span>: ViiV Healthcare, Durham, NC, USA.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author35\"> </a></p><blockquote><p/><p><a name=\"author35\"> </a></p><p><b>name</b>: Kimberly Smith </p></blockquote><p><b>forenameInitials</b>: K</p><p><b>affiliation</b>: <span>: ViiV Healthcare, Durham, NC, USA.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author36\"> </a></p><blockquote><p/><p><a name=\"author36\"> </a></p><p><b>name</b>: Brett Hanscom </p></blockquote><p><b>forenameInitials</b>: B</p><p><b>affiliation</b>: <span>: Statistical Centre for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author37\"> </a></p><blockquote><p/><p><a name=\"author37\"> </a></p><p><b>name</b>: Myron S Cohen </p></blockquote><p><b>forenameInitials</b>: MS</p><p><b>affiliation</b>: <span>: University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author38\"> </a></p><blockquote><p/><p><a name=\"author38\"> </a></p><p><b>name</b>: Mina C Hosseinipour </p></blockquote><p><b>forenameInitials</b>: MC</p><p><b>affiliation</b>: <span>: University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; UNC Project-Malawi, Lilongwe, Malawi.</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"author39\"> </a></p><blockquote><p/><p><a name=\"author39\"> </a></p><p><b>name</b>: HPTN 084 study group</p></blockquote></blockquote></blockquote></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author0</b><a name=\"author0\"> </a></p><p><b>name</b>: Sinead Delany-Moretlwe </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author1</b><a name=\"author1\"> </a></p><p><b>name</b>: James P Hughes </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author2</b><a name=\"author2\"> </a></p><p><b>name</b>: Peter Bock </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author3</b><a name=\"author3\"> </a></p><p><b>name</b>: Samuel Gurrion Ouma </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author4</b><a name=\"author4\"> </a></p><p><b>name</b>: Portia Hunidzarira </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author5</b><a name=\"author5\"> </a></p><p><b>name</b>: Dishiki Kalonji </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author6</b><a name=\"author6\"> </a></p><p><b>name</b>: Noel Kayange </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author7</b><a name=\"author7\"> </a></p><p><b>name</b>: Joseph Makhema </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author8</b><a name=\"author8\"> </a></p><p><b>name</b>: Patricia Mandima </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author9</b><a name=\"author9\"> </a></p><p><b>name</b>: Carrie Mathew </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author10</b><a name=\"author10\"> </a></p><p><b>name</b>: Elizabeth Spooner </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author11</b><a name=\"author11\"> </a></p><p><b>name</b>: Juliet Mpendo </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author12</b><a name=\"author12\"> </a></p><p><b>name</b>: Pamela Mukwekwerere </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author13</b><a name=\"author13\"> </a></p><p><b>name</b>: Nyaradzo Mgodi </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author14</b><a name=\"author14\"> </a></p><p><b>name</b>: Patricia Nahirya Ntege </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author15</b><a name=\"author15\"> </a></p><p><b>name</b>: Gonasagrie Nair </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author16</b><a name=\"author16\"> </a></p><p><b>name</b>: Clemensia Nakabiito </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author17</b><a name=\"author17\"> </a></p><p><b>name</b>: Harriet Nuwagaba-Biribonwoha </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author18</b><a name=\"author18\"> </a></p><p><b>name</b>: Ravindre Panchia </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author19</b><a name=\"author19\"> </a></p><p><b>name</b>: Nishanta Singh </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author20</b><a name=\"author20\"> </a></p><p><b>name</b>: Bekezela Siziba </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author21</b><a name=\"author21\"> </a></p><p><b>name</b>: Jennifer Farrior </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author22</b><a name=\"author22\"> </a></p><p><b>name</b>: Scott Rose </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author23</b><a name=\"author23\"> </a></p><p><b>name</b>: Peter L Anderson </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author24</b><a name=\"author24\"> </a></p><p><b>name</b>: Susan H Eshleman </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author25</b><a name=\"author25\"> </a></p><p><b>name</b>: Mark A Marzinke </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author26</b><a name=\"author26\"> </a></p><p><b>name</b>: Craig W Hendrix </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author27</b><a name=\"author27\"> </a></p><p><b>name</b>: Stephanie Beigel-Orme </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author28</b><a name=\"author28\"> </a></p><p><b>name</b>: Sybil Hosek </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author29</b><a name=\"author29\"> </a></p><p><b>name</b>: Elizabeth Tolley </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author30</b><a name=\"author30\"> </a></p><p><b>name</b>: Nirupama Sista </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author31</b><a name=\"author31\"> </a></p><p><b>name</b>: Adeola Adeyeye </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author32</b><a name=\"author32\"> </a></p><p><b>name</b>: James F Rooney </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author33</b><a name=\"author33\"> </a></p><p><b>name</b>: Alex Rinehart </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author34</b><a name=\"author34\"> </a></p><p><b>name</b>: William R Spreen </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author35</b><a name=\"author35\"> </a></p><p><b>name</b>: Kimberly Smith </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author36</b><a name=\"author36\"> </a></p><p><b>name</b>: Brett Hanscom </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author37</b><a name=\"author37\"> </a></p><p><b>name</b>: Myron S Cohen </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #author38</b><a name=\"author38\"> </a></p><p><b>name</b>: Mina C Hosseinipour </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Organization #author39</b><a name=\"author39\"> </a></p><p><b>name</b>: HPTN 084 study group</p></blockquote><hr/><blockquote><p><b>Generated Narrative: ArtifactAssessment #meshHeading0</b><a name=\"meshHeading0\"> </a></p><p><b>artifact</b>: <a href=\"#\">#</a></p><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading "MeSH heading")</span></p><p><b>classifier</b>: Adult <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D000328)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading "MeSH heading")</span></p><p><b>classifier</b>: Anti-HIV Agents <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D019380)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is Major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading "MeSH heading")</span></p><p><b>classifier</b>: Child <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D002648)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading "MeSH heading")</span></p><p><b>classifier</b>: Diketopiperazines <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D054659)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading "MeSH heading")</span></p><p><b>classifier</b>: Emtricitabine <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D000068679)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: therapeutic use <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000627)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading "MeSH heading")</span></p><p><b>classifier</b>: Female <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D005260)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading "MeSH heading")</span></p><p><b>classifier</b>: HIV Infections <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D015658)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is Major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: chemically induced <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000139)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: epidemiology <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000453)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: prevention & control <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000517)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading "MeSH heading")</span></p><p><b>classifier</b>: HIV Seropositivity <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D006679)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is Major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: drug therapy <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000188)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading "MeSH heading")</span></p><p><b>classifier</b>: HIV-1 <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D015497)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is Major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading "MeSH heading")</span></p><p><b>classifier</b>: Humans <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D006801)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading "MeSH heading")</span></p><p><b>classifier</b>: Infant, Newborn <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D007231)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading "MeSH heading")</span></p><p><b>classifier</b>: Pregnancy <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D011247)</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td>qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td><td>is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: classifier</p><p><b>type</b>: components (if present) include qualifier codings <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#mesh-heading "MeSH heading")</span></p><p><b>classifier</b>: Pyridones <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#D011728)</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: is not a major topic <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: qualifier <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ()</span></p><p><b>classifier</b>: therapeutic use <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (#Q000627)</span></p><blockquote><p><b>component</b></p></blockquote></blockquote></blockquote></blockquote></div>" ] ; # fhir:contained ( [ a fhir:Practitioner ; fhir:id [ fhir:v "author0" ] ; ( fhir:name [ fhir:family [ fhir:v "Delany-Moretlwe" ] ; ( fhir:given [ fhir:v "Sinead" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author1" ] ; ( fhir:name [ fhir:family [ fhir:v "Hughes" ] ; ( fhir:given [ fhir:v "James P" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author2" ] ; ( fhir:name [ fhir:family [ fhir:v "Bock" ] ; ( fhir:given [ fhir:v "Peter" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author3" ] ; ( fhir:name [ fhir:family [ fhir:v "Ouma" ] ; ( fhir:given [ fhir:v "Samuel Gurrion" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author4" ] ; ( fhir:name [ fhir:family [ fhir:v "Hunidzarira" ] ; ( fhir:given [ fhir:v "Portia" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author5" ] ; ( fhir:name [ fhir:family [ fhir:v "Kalonji" ] ; ( fhir:given [ fhir:v "Dishiki" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author6" ] ; ( fhir:name [ fhir:family [ fhir:v "Kayange" ] ; ( fhir:given [ fhir:v "Noel" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author7" ] ; ( fhir:name [ fhir:family [ fhir:v "Makhema" ] ; ( fhir:given [ fhir:v "Joseph" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author8" ] ; ( fhir:name [ fhir:family [ fhir:v "Mandima" ] ; ( fhir:given [ fhir:v "Patricia" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author9" ] ; ( fhir:name [ fhir:family [ fhir:v "Mathew" ] ; ( fhir:given [ fhir:v "Carrie" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author10" ] ; ( fhir:name [ fhir:family [ fhir:v "Spooner" ] ; ( fhir:given [ fhir:v "Elizabeth" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author11" ] ; ( fhir:name [ fhir:family [ fhir:v "Mpendo" ] ; ( fhir:given [ fhir:v "Juliet" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author12" ] ; ( fhir:name [ fhir:family [ fhir:v "Mukwekwerere" ] ; ( fhir:given [ fhir:v "Pamela" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author13" ] ; ( fhir:name [ fhir:family [ fhir:v "Mgodi" ] ; ( fhir:given [ fhir:v "Nyaradzo" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author14" ] ; ( fhir:name [ fhir:family [ fhir:v "Ntege" ] ; ( fhir:given [ fhir:v "Patricia Nahirya" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author15" ] ; ( fhir:name [ fhir:family [ fhir:v "Nair" ] ; ( fhir:given [ fhir:v "Gonasagrie" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author16" ] ; ( fhir:name [ fhir:family [ fhir:v "Nakabiito" ] ; ( fhir:given [ fhir:v "Clemensia" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author17" ] ; ( fhir:name [ fhir:family [ fhir:v "Nuwagaba-Biribonwoha" ] ; ( fhir:given [ fhir:v "Harriet" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author18" ] ; ( fhir:name [ fhir:family [ fhir:v "Panchia" ] ; ( fhir:given [ fhir:v "Ravindre" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author19" ] ; ( fhir:name [ fhir:family [ fhir:v "Singh" ] ; ( fhir:given [ fhir:v "Nishanta" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author20" ] ; ( fhir:name [ fhir:family [ fhir:v "Siziba" ] ; ( fhir:given [ fhir:v "Bekezela" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author21" ] ; ( fhir:name [ fhir:family [ fhir:v "Farrior" ] ; ( fhir:given [ fhir:v "Jennifer" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author22" ] ; ( fhir:name [ fhir:family [ fhir:v "Rose" ] ; ( fhir:given [ fhir:v "Scott" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author23" ] ; ( fhir:name [ fhir:family [ fhir:v "Anderson" ] ; ( fhir:given [ fhir:v "Peter L" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author24" ] ; ( fhir:name [ fhir:family [ fhir:v "Eshleman" ] ; ( fhir:given [ fhir:v "Susan H" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author25" ] ; ( fhir:name [ fhir:family [ fhir:v "Marzinke" ] ; ( fhir:given [ fhir:v "Mark A" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author26" ] ; ( fhir:name [ fhir:family [ fhir:v "Hendrix" ] ; ( fhir:given [ fhir:v "Craig W" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author27" ] ; ( fhir:name [ fhir:family [ fhir:v "Beigel-Orme" ] ; ( fhir:given [ fhir:v "Stephanie" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author28" ] ; ( fhir:name [ fhir:family [ fhir:v "Hosek" ] ; ( fhir:given [ fhir:v "Sybil" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author29" ] ; ( fhir:name [ fhir:family [ fhir:v "Tolley" ] ; ( fhir:given [ fhir:v "Elizabeth" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author30" ] ; ( fhir:name [ fhir:family [ fhir:v "Sista" ] ; ( fhir:given [ fhir:v "Nirupama" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author31" ] ; ( fhir:name [ fhir:family [ fhir:v "Adeyeye" ] ; ( fhir:given [ fhir:v "Adeola" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author32" ] ; ( fhir:name [ fhir:family [ fhir:v "Rooney" ] ; ( fhir:given [ fhir:v "James F" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author33" ] ; ( fhir:name [ fhir:family [ fhir:v "Rinehart" ] ; ( fhir:given [ fhir:v "Alex" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author34" ] ; ( fhir:name [ fhir:family [ fhir:v "Spreen" ] ; ( fhir:given [ fhir:v "William R" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author35" ] ; ( fhir:name [ fhir:family [ fhir:v "Smith" ] ; ( fhir:given [ fhir:v "Kimberly" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author36" ] ; ( fhir:name [ fhir:family [ fhir:v "Hanscom" ] ; ( fhir:given [ fhir:v "Brett" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author37" ] ; ( fhir:name [ fhir:family [ fhir:v "Cohen" ] ; ( fhir:given [ fhir:v "Myron S" ] ) ] ) ] [ a fhir:Practitioner ; fhir:id [ fhir:v "author38" ] ; ( fhir:name [ fhir:family [ fhir:v "Hosseinipour" ] ; ( fhir:given [ fhir:v "Mina C" ] ) ] ) ] [ a fhir:Organization ; fhir:id [ fhir:v "author39" ] ; fhir:name [ fhir:v "HPTN 084 study group" ] ] [ a fhir:ArtifactAssessment ; fhir:id [ fhir:v "meshHeading0" ] ; fhir:artifact [ a fhir:Reference ; fhir:reference [ fhir:v "#" ] ; fhir:type [ fhir:v "Citation"^^xsd:anyURI ] ] ; ( fhir:content [ fhir:informationType [ fhir:v "classifier" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D000328" ] ; fhir:display [ fhir:v "Adult" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:informationType [ fhir:v "classifier" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D019380" ] ; fhir:display [ fhir:v "Anti-HIV Agents" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is Major topic" ] ] ) ] ) ] [ fhir:informationType [ fhir:v "classifier" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D002648" ] ; fhir:display [ fhir:v "Child" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:informationType [ fhir:v "classifier" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D054659" ] ; fhir:display [ fhir:v "Diketopiperazines" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:informationType [ fhir:v "classifier" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D000068679" ] ; fhir:display [ fhir:v "Emtricitabine" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000627" ] ; fhir:display [ fhir:v "therapeutic use" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49487" ] ; fhir:display [ fhir:v "No" ] ] ) ] ) ] ) ] ) ] [ fhir:informationType [ fhir:v "classifier" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D005260" ] ; fhir:display [ fhir:v "Female" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:informationType [ fhir:v "classifier" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D015658" ] ; fhir:display [ fhir:v "HIV Infections" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is Major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000139" ] ; fhir:display [ fhir:v "chemically induced" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49487" ] ; fhir:display [ fhir:v "No" ] ] ) ] ) ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000453" ] ; fhir:display [ fhir:v "epidemiology" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49487" ] ; fhir:display [ fhir:v "No" ] ] ) ] ) ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000517" ] ; fhir:display [ fhir:v "prevention & control" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49487" ] ; fhir:display [ fhir:v "No" ] ] ) ] ) ] ) ] ) ] [ fhir:informationType [ fhir:v "classifier" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D006679" ] ; fhir:display [ fhir:v "HIV Seropositivity" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is Major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000188" ] ; fhir:display [ fhir:v "drug therapy" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49487" ] ; fhir:display [ fhir:v "No" ] ] ) ] ) ] ) ] ) ] [ fhir:informationType [ fhir:v "classifier" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D015497" ] ; fhir:display [ fhir:v "HIV-1" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is Major topic" ] ] ) ] ) ] [ fhir:informationType [ fhir:v "classifier" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D006801" ] ; fhir:display [ fhir:v "Humans" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:informationType [ fhir:v "classifier" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D007231" ] ; fhir:display [ fhir:v "Infant, Newborn" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:informationType [ fhir:v "classifier" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D011247" ] ; fhir:display [ fhir:v "Pregnancy" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] ) ] [ fhir:informationType [ fhir:v "classifier" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "mesh-heading" ] ; fhir:display [ fhir:v "MeSH heading" ] ] ) ; fhir:text [ fhir:v "components (if present) include qualifier codings" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "D011728" ] ; fhir:display [ fhir:v "Pyridones" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ; fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ fhir:text [ fhir:v "is not a major topic" ] ] ) ] [ fhir:type [ fhir:text [ fhir:v "qualifier" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ; fhir:code [ fhir:v "Q000627" ] ; fhir:display [ fhir:v "therapeutic use" ] ] ) ] ) ; ( fhir:component [ fhir:type [ fhir:text [ fhir:v "is Major topic" ] ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ; fhir:code [ fhir:v "C49487" ] ; fhir:display [ fhir:v "No" ] ] ) ] ) ] ) ] ) ] ) ] ) ; # fhir:extension ( [ fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg"^^xsd:anyURI ] ; fhir:value [ fhir:v "cds" ] ] ) ; # fhir:url [ fhir:v "https://fevir.net/resources/Citation/153881"^^xsd:anyURI] ; # fhir:identifier ( [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ; fhir:code [ fhir:v "ACSN" ] ; fhir:display [ fhir:v "Accession ID" ] ] ) ; fhir:text [ fhir:v "FEvIR Object Identifier" ] ] ; fhir:system [ fhir:v "https://fevir.net"^^xsd:anyURI ] ; fhir:value [ fhir:v "153881" ] ; fhir:assigner [ fhir:display [ fhir:v "Computable Publishing LLC" ] ] ] [ fhir:system [ fhir:v "https://pubmed.ncbi.nlm.nih.gov"^^xsd:anyURI ] ; fhir:value [ fhir:v "35378077" ] ] ) ; # fhir:version [ fhir:v "1.0.0-ballot"] ; # fhir:title [ fhir:v "Delany-Moretlwe 2022 clinical trial"] ; # fhir:status [ fhir:v "active"] ; # fhir:date [ fhir:v "2023-12-17T16:55:23+00:00"^^xsd:dateTime] ; # fhir:publisher [ fhir:v "HL7 International / Clinical Decision Support"] ; # fhir:contact ( [ fhir:name [ fhir:v "HL7 International / Clinical Decision Support" ] ; ( fhir:telecom [ fhir:system [ fhir:v "url" ] ; fhir:value [ fhir:v "http://www.hl7.org/Special/committees/dss" ] ] ) ] ) ; # fhir:description [ fhir:v "This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide."] ; # fhir:useContext ( [ fhir:code [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "fevir-platform-use" ] ; fhir:display [ fhir:v "FEvIR Platform Use" ] ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-artifact-classifier"^^xsd:anyURI ] ; fhir:code [ fhir:v "project-specific" ] ; fhir:display [ fhir:v "Project Specific" ] ] ) ] ] ) ; # fhir:jurisdiction ( [ ( fhir:coding [ fhir:system [ fhir:v "http://unstats.un.org/unsd/methods/m49/m49.htm"^^xsd:anyURI ] ; fhir:code [ fhir:v "001" ] ; fhir:display [ fhir:v "World" ] ] ) ] ) ; # fhir:copyright [ fhir:v "https://creativecommons.org/licenses/by-nc-sa/4.0/"] ; # fhir:approvalDate [ fhir:v "2022-05-10"^^xsd:date] ; # fhir:lastReviewDate [ fhir:v "2023-03-17"^^xsd:date] ; # fhir:author ( [ fhir:name [ fhir:v "Brian S. Alper" ] ] [ fhir:name [ fhir:v "Computable Publishing®: MEDLINE-to-FEvIR Converter" ] ] ) ; # fhir:classification ( [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "citation-source" ] ; fhir:display [ fhir:v "Citation Source" ] ] ) ] ; ( fhir:classifier [ fhir:text [ fhir:v "MEDLINE" ] ] ) ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-classification-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "medline-owner" ] ; fhir:display [ fhir:v "MEDLINE Citation Owner" ] ] ) ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#owner_value"^^xsd:anyURI ] ; fhir:code [ fhir:v "NLM" ] ; fhir:display [ fhir:v "National Library of Medicine, Index Section" ] ; fhir:userSelected [ fhir:v "false"^^xsd:boolean ] ] ) ] ) ] ) ; # fhir:currentState ( [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "medline-medline" ] ; fhir:display [ fhir:v "Medline Citation Status of Medline" ] ] ) ] [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "pubmed-publication-status-ppublish" ] ; fhir:display [ fhir:v "PubMed PublicationStatus of ppublish" ] ] ) ] ) ; # fhir:statusDate ( [ fhir:activity [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "pubmed-pubstatus-received" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Received" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2022-02-27"^^xsd:date ] ] ] [ fhir:activity [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "pubmed-pubstatus-revised" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Revised" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2022-03-12"^^xsd:date ] ] ] [ fhir:activity [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "pubmed-pubstatus-accepted" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Accepted" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2022-03-14"^^xsd:date ] ] ] [ fhir:activity [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "pubmed-pubstatus-pubmed" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Pubmed" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2022-04-05T06:00:00.000Z"^^xsd:dateTime ] ] ] [ fhir:activity [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "pubmed-pubstatus-medline" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Medline" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2022-05-11T06:00:00.000Z"^^xsd:dateTime ] ] ] [ fhir:activity [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "pubmed-pubstatus-entrez" ] ; fhir:display [ fhir:v "PubMed Pubstatus of Entrez" ] ] ) ] ; fhir:period [ fhir:end [ fhir:v "2022-04-04T20:10:00.000Z"^^xsd:dateTime ] ] ] ) ; # fhir:citedArtifact [ ( fhir:identifier [ fhir:system [ fhir:v "https://pubmed.ncbi.nlm.nih.gov"^^xsd:anyURI ] ; fhir:value [ fhir:v "35378077" ] ] [ fhir:system [ fhir:v "https://www.ncbi.nlm.nih.gov/pmc/"^^xsd:anyURI ] ; fhir:value [ fhir:v "PMC9077443" ] ] [ fhir:system [ fhir:v "https://doi.org"^^xsd:anyURI ] ; fhir:value [ fhir:v "10.1016/S0140-6736(22)00538-4" ] ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ; fhir:code [ fhir:v "ACSN" ] ; fhir:display [ fhir:v "Accession ID" ] ] ) ; fhir:text [ fhir:v "pii" ] ] ; fhir:value [ fhir:v "S0140-6736(22)00538-4" ] ] ) ; ( fhir:relatedIdentifier [ fhir:system [ fhir:v "https://clinicaltrials.gov"^^xsd:anyURI ] ; fhir:value [ fhir:v "NCT03164564" ] ; fhir:assigner [ fhir:display [ fhir:v "ClinicalTrials.gov" ] ] ] ) ; ( fhir:title [ ( fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/title-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "primary" ] ; fhir:display [ fhir:v "Primary title" ] ] ) ] ) ; fhir:language [ ( fhir:coding [ fhir:system [ fhir:v "urn:ietf:bcp:47"^^xsd:anyURI ] ; fhir:code [ fhir:v "en" ] ; fhir:display [ fhir:v "English" ] ] ) ] ; fhir:text [ fhir:v "Cabotegravir for the prevention of HIV-1 in women: results from HPTN 084, a phase 3, randomised clinical trial." ] ] ) ; ( fhir:abstract [ fhir:text [ fhir:v "**BACKGROUND:** Oral pre-exposure prophylaxis has been introduced in more than 70 countries, including many in sub-Saharan Africa, but women experience considerable barriers to daily pill-taking, such as stigma, judgement, and the fear of violence. Safe and effective long-acting agents for HIV prevention are needed for women. We aimed to evaluate the safety and efficacy of injectable cabotegravir compared with daily oral tenofovir diphosphate plus emtricitabine (TDF-FTC) for HIV prevention in HIV-uninfected women.\n**METHODS:** HPTN 084 was a phase 3, randomised, double-blind, double-dummy, active-controlled, superiority trial in 20 clinical research sites in seven countries in sub-Saharan Africa. Participants were eligible for enrolment if they were assigned female sex at birth, were aged 18-45 years, reported at least two episodes of vaginal intercourse in the previous 30 days, were at risk of HIV infection based on an HIV risk score, and agreed to use a long-acting reversible contraceptive method. Participants were randomly assigned (1:1) to either active cabotegravir with TDF-FTC placebo (cabotegravir group) or active TDF-FTC with cabotegravir placebo (TDF-FTC group). Study staff and participants were masked to study group allocation, with the exception of the site pharmacist who was responsible for study product preparation. Participants were prescribed 5 weeks of daily oral product followed by intramuscular injections every 8 weeks after an initial 4-week interval load, alongside daily oral pills. Participants who discontinued injections were offered open-label daily TDF-FTC for 48 weeks. The primary endpoints of the study were incident HIV infection in the intention-to-treat population, and clinical and laboratory events that were grade 2 or higher in all women who had received at least one dose of study product. This study is registered with ClinicalTrials.gov, NCT03164564.\n**FINDINGS:** From Nov 27, 2017, to Nov 4, 2020, we enrolled 3224 participants (1614 in the cabotegravir group and 1610 in the TDF-FTC group). Median age was 25 years (IQR 22-30); 1755 (54·7%) of 3209 had two or more partners in the preceding month. 40 incident infections were observed over 3898 person-years (HIV incidence 1·0% [95% CI 0·73-1·40]); four in the cabotegravir group (HIV incidence 0·2 cases per 100 person-years [0·06-0·52]) and 36 in the TDF-FTC group (1·85 cases per 100 person-years [1·3-2·57]; hazard ratio 0·12 [0·05-0·31]; p<0·0001; risk difference -1·6% [-1·0% to -2·3%]. In a random subset of 405 TDF-FTC participants, 812 (42·1%) of 1929 plasma samples had tenofovir concentrations consistent with daily use. Injection coverage was 93% of the total number of person-years. Adverse event rates were similar across both groups, apart from injection site reactions, which were more frequent in the cabotegravir group than in the TDF-FTC group (577 [38·0%] of 1519 vs 162 [10·7%] of 1516]) but did not result in injection discontinuation. Confirmed pregnancy incidence was 1·3 per 100 person-years (0·9-1·7); no congenital birth anomalies were reported.\n**INTERPRETATION:** Although both products for HIV prevention were generally safe, well tolerated, and effective, cabotegravir was superior to TDF-FTC in preventing HIV infection in women.\n**FUNDING:** National Institute of Allergy and Infectious Diseases, ViiV Healthcare, and the Bill & Melinda Gates Foundation. Additional support was provided through the National Institute of Mental Health, the National Institute on Drug Abuse, and the Eunice Kennedy Shriver National Institute of Child Health and Human Development. ViiV Healthcare and Gilead Sciences provided pharmaceutical support." ] ; fhir:copyright [ fhir:v "Copyright © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved." ] ] ) ; ( fhir:relatesTo [ fhir:type [ fhir:v "cites" ] ; fhir:citation [ fhir:v "UNAIDS Confronting inequalities: lessons for pandemic responses from 40 years of AIDS. July 14, 2021. https://www.unaids.org/en/resources/documents/2021/2021-global-aids-update-slideset" ] ] [ fhir:type [ fhir:v "cites" ] ; fhir:citation [ fhir:v "WHO . World Health Organization; Geneva: 2015. Policy brief: pre-exposure prophylaxis (PrEP): WHO expands recommendation on oral pre-exposure prophylaxis of HIV infection (PrEP)" ] ] [ fhir:type [ fhir:v "cites" ] ; ( fhir:classifier [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/citation-artifact-classifier"^^xsd:anyURI ] ; fhir:code [ fhir:v "D016428" ] ; fhir:display [ fhir:v "Journal Article" ] ] ) ] ) ; fhir:citation [ fhir:v "Celum CL, Delany-Moretlwe S, Baeten JM, et al. HIV pre-exposure prophylaxis for adolescent girls and young women in Africa: from efficacy trials to delivery. 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fhir:forenameInitials [ fhir:v "N" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "HIV and other Infectious Diseases Research Unit, South African Medical Research Council, Durban, South Africa." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#author20" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Siziba B" ] ] ; fhir:forenameInitials [ fhir:v "B" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Clinical Trials Research Centre, University of Zimbabwe, Harare, Zimbabwe." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#author21" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Farrior J" ] ] ; fhir:forenameInitials [ fhir:v "J" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "FHI 360, Durham, NC, USA." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#author22" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Rose S" ] ] ; fhir:forenameInitials [ fhir:v "S" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "FHI 360, Durham, NC, USA." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#author23" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Anderson PL" ] ] ; fhir:forenameInitials [ fhir:v "PL" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Anschutz Medical Campus, University of Colorado, Aurora, CO, USA." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#author24" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Eshleman SH" ] ] ; fhir:forenameInitials [ fhir:v "SH" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#author25" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Marzinke MA" ] ] ; fhir:forenameInitials [ fhir:v "MA" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#author26" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Hendrix CW" ] ] ; fhir:forenameInitials [ fhir:v "CW" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#author27" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Beigel-Orme S" ] ] ; fhir:forenameInitials [ fhir:v "S" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Statistical Centre for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#author28" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Hosek S" ] ] ; fhir:forenameInitials [ fhir:v "S" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Department of Psychiatry, Stroger Hospital of Cook County, Chicago, IL, USA." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#author29" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Tolley E" ] ] ; fhir:forenameInitials [ fhir:v "E" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "FHI 360, Durham, NC, USA." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#author30" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Sista N" ] ] ; fhir:forenameInitials [ fhir:v "N" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "FHI 360, Durham, NC, USA." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#author31" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Adeyeye A" ] ] ; fhir:forenameInitials [ fhir:v "A" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Division of AIDS, National Institute of Allergy and Infectious Diseases, Rockville, MD, USA." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#author32" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Rooney JF" ] ] ; fhir:forenameInitials [ fhir:v "JF" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Gilead Sciences, Foster City, CA, USA." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#author33" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Rinehart A" ] ] ; fhir:forenameInitials [ fhir:v "A" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "ViiV Healthcare, Durham, NC, USA." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#author34" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Spreen WR" ] ] ; fhir:forenameInitials [ fhir:v "WR" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "ViiV Healthcare, Durham, NC, USA." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#author35" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Smith K" ] ] ; fhir:forenameInitials [ fhir:v "K" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "ViiV Healthcare, Durham, NC, USA." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#author36" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Hanscom B" ] ] ; fhir:forenameInitials [ fhir:v "B" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "Statistical Centre for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#author37" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Cohen MS" ] ] ; fhir:forenameInitials [ fhir:v "MS" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#author38" ] ; fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ; fhir:display [ fhir:v "Hosseinipour MC" ] ] ; fhir:forenameInitials [ fhir:v "MC" ] ; ( fhir:affiliation [ fhir:display [ fhir:v "University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; UNC Project-Malawi, Lilongwe, Malawi." ] ] ) ] [ fhir:contributor [ fhir:reference [ fhir:v "#author39" ] ; fhir:type [ fhir:v "Organization"^^xsd:anyURI ] ; fhir:display [ fhir:v "HPTN 084 study group" ] ] ] ) ] ] . #
IG © 2022+ HL7 International / Clinical Decision Support. Package hl7.fhir.uv.ebm#1.0.0-ballot based on FHIR 5.0.0. Generated 2023-12-17
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