Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot - ballot International flag

This page is part of the Evidence Based Medicine on FHIR Implementation Guide (v1.0.0-ballot: STU1 Ballot 1) based on FHIR (HL7® FHIR® Standard) v5.0.0. . For a full list of available versions, see the Directory of published versions

Example ArtifactAssessment: Certainty of Evidence Rating of 14-day mortality remdesivir vs placebo meta-analysis (ACTT-1, Wang et al, WHO SOLIDARITY)

Generated Narrative: ArtifactAssessment

Resource ArtifactAssessment "179693" Version "6" Updated "2023-12-04 21:34:42+0000"

Profile: CertaintyOfEvidence

Artifact URL: https://fevir.net/resources/ArtifactAssessment/179693

Artifact Description: This example of a CertaintyOfEvidence Profile shows a recursive pattern of component elements with type/classifier paired values for different aspects of rating the certainty of evidence.

identifier: FEvIR Object Identifier: 179693

title: Certainty of Evidence Rating of 14-day mortality remdesivir vs placebo meta-analysis (ACTT-1, Wang et al, WHO SOLIDARITY)

artifact: Evidence/55: 14-day mortality remdesivir vs placebo meta-analysis (ACTT-1, Wang et al, WHO SOLIDARITY) "Fourteen_day_mortality_remdesivir_vs_placebo_meta_analysis_ACTT_1_Wang_et_al_WHO_SOLIDARITY"

content

informationType: rating

summary: Low certainty due to inconsistency and risk of bias

type: Overall certainty (Evidence Certainty Type#Overall)

classifier: Low quality (Evidence Certainty Rating#low)

component

informationType: rating

type: Publication bias (Evidence Certainty Type#PublicationBias)

classifier: no serious concern (Evidence Certainty Rating#no-concern)

component

informationType: rating

summary: There is a high degree of heterogeneity (I-squared = 73%). There is also inconsistency in findings between the fixed-effect and random-effects statistical models.

type: Inconsistency (Evidence Certainty Type#Inconsistency)

classifier: serious concern (Evidence Certainty Rating#serious-concern)

component

informationType: rating

summary: Although the random-effects analysis finds an estimate without statistical significance, this imprecision is explained by the inconsistency (heterogeneity) and thus not further downrated in certainty assessment.

type: Imprecision (Evidence Certainty Type#Imprecision)

classifier: no serious concern (Evidence Certainty Rating#no-concern)

component

informationType: rating

type: Indirectness (Evidence Certainty Type#Indirectness)

classifier: no serious concern (Evidence Certainty Rating#no-concern)

component

informationType: rating

type: Risk of bias (Evidence Certainty Type#RiskOfBias)

classifier: serious concern (Evidence Certainty Rating#serious-concern)

component