FHIR Clinical Guidelines (v1.0.0) (STU 1)

This page is part of the Clinical Guidelines (v1.0.0: STU 1) based on FHIR R4. This is the current published version. For a full list of available versions, see the Directory of published versions
CKDRiskLogic

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{
  "resourceType" : "Library",
  "id" : "CKDRiskLogic",
  "meta" : {
    "profile" : [
      "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-computablelibrary"
    ]
  },
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><h2>Contents</h2><p><code>text/cql</code></p><pre><code class=\"language-sql\">library CKDRiskLogic version '1.0'\n\nusing FHIR version '4.0.0'\n\ninclude FHIRHelpers version '4.0.0' called FHIRHelpers\n\ncodesystem \"SNOMEDCT\": 'http://snomed.info/sct'\ncodesystem \"LOINC\": 'http://loinc.org'\ncodesystem \"RxNorm\": 'http://www.nlm.nih.gov/research/umls/rxnorm'\n\nvalueset \"Chronic Kidney Disease\": 'ckd-valueset-ckd'\nvalueset \"Diabetes mellitus\": 'ckd-valueset-diabetes'\n\nvalueset \"eGFR Labs\": 'ckd-valueset-egfr'\nvalueset \"UACR Labs\": 'ckd-valueset-uacr'\nvalueset \"Creatinine Labs\": 'ckd-valueset-creatinine'\n\ncode \"Blood pressure systolic and diastolic\": '55284-4' from \"LOINC\"\n\ncontext Patient\n\n// Conditions\n//\ndefine \"Has CKD or Diabetes\":\n  \"Has CKD\" or \"Has Diabetes\"\n\ndefine \"Has CKD\":\n  exists( \"Chronic Kidney Disease Dx\" )\n\ndefine \"Has Diabetes\":\n  exists( \"Diabetes Dx\" )\n\ndefine \"CKD or Diabetes Dx\":\n  \"Chronic Kidney Disease Dx\" union \"Diabetes Dx\"\n\ndefine \"Chronic Kidney Disease Dx\":\n  [Condition: code in \"Chronic Kidney Disease\"] condition\n    where condition.clinicalStatus.value in { 'active', 'recurrence' }\n\ndefine \"Diabetes Dx\":\n  [Condition: code in \"Diabetes mellitus\"] condition\n    where condition.clinicalStatus.value in { 'active', 'recurrence' }\n\n// Laboratory observations\n//\ndefine \"Has eGFR or UACR Lab\":\n  \"Last eGFR Lab Result\" is not null\n\tor \"Last UACR Lab Result\" is not null\n\ndefine \"Last eGFR Lab Result\":\n  Last( [Observation: code in \"eGFR Labs\"] )\n\ndefine \"Last eGFR Quantity\":\n  \"Last eGFR Lab Result\" Result\n    return ToQuantity(Result.value as Quantity)\n\ndefine \"Has Abnormal eGFR\":\n  \"Last eGFR Quantity\".value &lt; 60\n\ndefine \"Last UACR Lab Result\":\n  Last( [Observation: code in \"UACR Labs\"] )\n\ndefine \"Last UACR Quantity\":\n  \"Last UACR Lab Result\" Result\n    return ToQuantity(Result.value as Quantity)\n\ndefine \"Has Abnormal UACR\":\n  \"Last UACR Quantity\" uacr\n    return UACRtoMetric(uacr).value &gt; 30\n\ndefine \"Last Creatinine Lab Result\":\n  Last( [Observation: code in \"Creatinine Labs\"] )\n\ndefine \"Last Creatinine Quantity\":\n  \"Last Creatinine Lab Result\" Result\n    return ToQuantity(Result.value as Quantity)\n\ndefine \"Needs eGFR Lab\":\n\t\"eGFR Lab is Overdue\"\n\t\tor (\"eGFR Lab Frequency\" is not null and \"Last eGFR Lab Result\" is null)\n\ndefine \"eGFR Lab Frequency\":\n\tcase\n\t\twhen \"CKD Stage\" &gt;= 4\n\t\t\tthen 3 months\n\t\twhen \"CKD Stage\" &gt;= 3\n\t\t\tthen 6 months\n\t\twhen \"Has CKD or Diabetes\"\n\t\t\tthen 12 months\n\t\telse null\n\tend\n\ndefine \"eGFR Lab is Overdue\":\n  \"Last eGFR Lab Result\" Result\n    return\n      case\n        when Result.effective is null\n          then true\n        when Result.effective is dateTime\n          then (Result.effective.value + \"eGFR Lab Frequency\") &lt; Today()\n        when Result.effective is Period\n          then (end of PeriodToInterval(Result.effective) + \"eGFR Lab Frequency\") &lt; Today()\n        else false\n      end\n\ndefine NeedsGFRSummary: 'Order Renal Lab Panel'\n\ndefine NeedsGFRDetail:\n\tcase\n\t\twhen \"CKD Stage\" &gt;= 1\n\t\t\tthen 'eGFR lab recommended every ' + ToString(\"eGFR Lab Frequency\") + ' for Stage ' + ToString(\"CKD Stage\") + ' CKD.'\n\t\twhen \"Has CKD or Diabetes\"\n\t\t\tthen 'eGFR lab recommended every ' + ToString(\"eGFR Lab Frequency\") + ' for CKD or Diabetes.'\n\t\telse null\n\tend\n\ndefine NeedsGFRSeverity: 'info'\n\ndefine \"CKD Stage\":\n  \"Last eGFR Quantity\" egfr\n  \treturn case\n      when egfr.value &lt; 15\n    \t\tthen 5\n    \twhen egfr.value &lt; 30\n    \t\tthen 4\n    \twhen egfr.value &lt; 60\n    \t\tthen 3\n    \twhen egfr.value &lt; 90\n    \t\tthen 2\n    \twhen egfr.value &gt;= 90\n        // TODO this does not parse\n        //case  when UACRtoMetric(\"Get UACR Quantity\").value &gt; 20\n  \t\t  //  then 1\n        //else 0\n        //end\n        then 0\n      else 0\n  \tend\n\n// Referrals\n//\ndefine \"Recommend Nephrology Referral\":\n\t\"5-Year Risk Level\" = 'High'\n\ndefine NephrologyReferralDetail: 'Referral to a nephrologist is recommended when 5-year risk is High'\n\ndefine NephrologyReferralSeverity: 'info'\n\n//\n// Tangri CKD risk model\n//\n// 4 variable\n// 1 – 0.9750 ^ exp (-0.2201 × (age/10 – 7.036) + 0.2467 × (male – 0.5642) – 0.5567 × (eGFR/5 – 7.222) + 0.4510 × (logACR – 5.137))\n// 5 year factor =  0.9240\n//\n// 8 variable\n// 1 – 0.9780 ^ exp (-0.1992 × (age/10 – 7.036) + 0.1602 × (male – 0.5642) – 0.4919 × (eGFR/5 – 7.222) + 0.3364 × (logACR – 5.137)\n//\t\t– 0.3441 × (albumin – 3.997) + 0.2604 × (phosphorous – 3.916) – 0.07354 × (bicarbonate – 25.57) – 0.2228 × (calcium – 9.355))\n// 5 year factor = 0.9301\n\ndefine \"2-YearRiskDetail\":\n\t'2-year kidney failure risk of ' + ToString(\"2-Year CKD Risk Percent\") + '% is considered to be ' + \"2-Year Risk Level\" + ' risk.'\n\ndefine \"5-YearRiskDetail\":\n\t'5-year kidney failure risk of ' + ToString(\"5-Year CKD Risk Percent\") + '% is considered to be ' + \"5-Year Risk Level\" + ' risk.'\n\ndefine \"2-YearRiskSeverity\": if \"2-Year Risk Level\" = 'High' then 'warning' else 'info'\n\ndefine \"5-YearRiskSeverity\": if \"5-Year Risk Level\" = 'High' then 'warning' else 'info'\n\ndefine \"2-Year CKD Risk Percent\":\n  \"2-Year CKD Risk\" risk\n    return Round(risk * 100, 2)\n\ndefine \"5-Year CKD Risk Percent\":\n  \"5-Year CKD Risk\" risk\n    return Round(risk * 100, 2)\n\ndefine \"2-Year CKD Risk\":\n  \"Last eGFR Quantity\" egfr\n    return calculateCkdRisk(0.9750, 0, AgeInYears(), egfr, UACRtoMetric(\"Last UACR Quantity\"))\n\ndefine \"5-Year CKD Risk\":\n  \"Last eGFR Quantity\" egfr\n    return calculateCkdRisk(0.9240, 0, AgeInYears(), egfr, UACRtoMetric(\"Last UACR Quantity\"))\n\n// The ckdFactor is a variable determined by (Non-) North American location and whether calculation is 2 or 5 year prediction\ndefine function calculateCkdRisk(ckdFactor Decimal, sex Integer, age Integer, egfr System.Quantity, acr System.Quantity):\n  1.0 - Power(ckdFactor, Exp(-0.2201 * (age / 10 - 7.036) + 0.2467 * (sex - 0.5642) - 0.5567 * (egfr.value / 5 - 7.222) + 0.4510 * (Ln(acr.value) - 5.137)))\n\ndefine \"2-Year Risk Level\":\n  \"2-Year CKD Risk Percent\" riskPercent\n  \treturn case\n      when riskPercent &lt; 5\n    \t\tthen 'Low'\n    \twhen riskPercent &lt; 15\n    \t\tthen 'Intermediate'\n    \twhen riskPercent &gt; 15\n    \t\tthen 'High'\n      else null\n  \tend\n\ndefine \"5-Year Risk Level\":\n  \"5-Year CKD Risk Percent\" riskPercent\n  \treturn case\n      when riskPercent &lt; 5\n    \t\tthen 'Low'\n    \twhen riskPercent &lt; 15\n    \t\tthen 'Intermediate'\n    \twhen riskPercent &gt; 15\n    \t\tthen 'High'\n      else null\n  \tend\n\n// Conversion functions\n\ndefine function PeriodToInterval(value FHIR.Period):\n\tInterval[value.\"start\".value, value.\"end\".value]\n\ndefine function CodingToCode(coding FHIR.Coding):\n\tSystem.Code {\n\t\tcode: coding.code.value,\n\t\tsystem: coding.system.value,\n\t\tversion: coding.version.value,\n\t\tdisplay: coding.display.value\n\t}\n\ndefine function ToConcept(concept FHIR.CodeableConcept):\n    System.Concept {\n        codes: concept.coding C return CodingToCode(C),\n        display: concept.text.value\n    }\n\ndefine function ToQuantity(quantity FHIR.Quantity):\n    System.Quantity {\n        value: quantity.value.value,\n        unit: quantity.unit.value\n    }\n\ndefine function UACRtoMetric(qty System.Quantity):\n\tcase when qty.unit = 'mg/mmol creatinine' then\n\t\tSystem.Quantity { value: qty.value * 8.84, unit: 'mg/g' }\n\twhen qty.unit = 'mg/g' then\n    qty\n\telse\n    // unknown units, ignore this quantity in calculation\n\t\tnull\n\tend\n\ndefine function ToMetric(qty System.Quantity):\n\tcase when qty.unit = 'lb' then\n\t\tSystem.Quantity { value: qty.value * 0.454, unit: 'kg' }\n\twhen qty.unit = 'in' then\n\t\tSystem.Quantity { value: qty.value * 0.0254, unit: 'm' }\n\telse\n\t\tqty\n\tend\n</code></pre></div>"
  },
  "extension" : [
    {
      "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability",
      "valueCode" : "shareable"
    },
    {
      "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability",
      "valueCode" : "computable"
    },
    {
      "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability",
      "valueCode" : "publishable"
    },
    {
      "url" : "http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeRepresentationLevel",
      "valueCode" : "structured"
    }
  ],
  "url" : "http://hl7.org/fhir/uv/cpg/Library/CKDRiskLogic",
  "version" : "1.0.0",
  "name" : "CKDRiskLogic",
  "title" : "Chronic Kidney Disease (CKD) risk screening logic",
  "status" : "active",
  "experimental" : true,
  "type" : {
    "coding" : [
      {
        "system" : "http://terminology.hl7.org/CodeSystem/library-type",
        "code" : "logic-library"
      }
    ]
  },
  "date" : "2021-02-11T20:43:58+00:00",
  "publisher" : "HL7 FHIR Clinical Guidelines Example Artifact",
  "description" : "Chronic Kidney Disease (CKD) risk screening logic",
  "jurisdiction" : [
    {
      "coding" : [
        {
          "system" : "http://unstats.un.org/unsd/methods/m49/m49.htm",
          "code" : "001",
          "display" : "World"
        }
      ]
    }
  ],
  "content" : [
    {
      "contentType" : "text/cql",
      "data" : "library CKDRiskLogic version '1.0'

using FHIR version '4.0.0'

include FHIRHelpers version '4.0.0' called FHIRHelpers

codesystem "SNOMEDCT": 'http://snomed.info/sct'
codesystem "LOINC": 'http://loinc.org'
codesystem "RxNorm": 'http://www.nlm.nih.gov/research/umls/rxnorm'

valueset "Chronic Kidney Disease": 'ckd-valueset-ckd'
valueset "Diabetes mellitus": 'ckd-valueset-diabetes'

valueset "eGFR Labs": 'ckd-valueset-egfr'
valueset "UACR Labs": 'ckd-valueset-uacr'
valueset "Creatinine Labs": 'ckd-valueset-creatinine'

code "Blood pressure systolic and diastolic": '55284-4' from "LOINC"

context Patient

// Conditions
//
define "Has CKD or Diabetes":
  "Has CKD" or "Has Diabetes"

define "Has CKD":
  exists( "Chronic Kidney Disease Dx" )

define "Has Diabetes":
  exists( "Diabetes Dx" )

define "CKD or Diabetes Dx":
  "Chronic Kidney Disease Dx" union "Diabetes Dx"

define "Chronic Kidney Disease Dx":
  [Condition: code in "Chronic Kidney Disease"] condition
    where condition.clinicalStatus.value in { 'active', 'recurrence' }

define "Diabetes Dx":
  [Condition: code in "Diabetes mellitus"] condition
    where condition.clinicalStatus.value in { 'active', 'recurrence' }

// Laboratory observations
//
define "Has eGFR or UACR Lab":
  "Last eGFR Lab Result" is not null
	or "Last UACR Lab Result" is not null

define "Last eGFR Lab Result":
  Last( [Observation: code in "eGFR Labs"] )

define "Last eGFR Quantity":
  "Last eGFR Lab Result" Result
    return ToQuantity(Result.value as Quantity)

define "Has Abnormal eGFR":
  "Last eGFR Quantity".value < 60

define "Last UACR Lab Result":
  Last( [Observation: code in "UACR Labs"] )

define "Last UACR Quantity":
  "Last UACR Lab Result" Result
    return ToQuantity(Result.value as Quantity)

define "Has Abnormal UACR":
  "Last UACR Quantity" uacr
    return UACRtoMetric(uacr).value > 30

define "Last Creatinine Lab Result":
  Last( [Observation: code in "Creatinine Labs"] )

define "Last Creatinine Quantity":
  "Last Creatinine Lab Result" Result
    return ToQuantity(Result.value as Quantity)

define "Needs eGFR Lab":
	"eGFR Lab is Overdue"
		or ("eGFR Lab Frequency" is not null and "Last eGFR Lab Result" is null)

define "eGFR Lab Frequency":
	case
		when "CKD Stage" >= 4
			then 3 months
		when "CKD Stage" >= 3
			then 6 months
		when "Has CKD or Diabetes"
			then 12 months
		else null
	end

define "eGFR Lab is Overdue":
  "Last eGFR Lab Result" Result
    return
      case
        when Result.effective is null
          then true
        when Result.effective is dateTime
          then (Result.effective.value + "eGFR Lab Frequency") < Today()
        when Result.effective is Period
          then (end of PeriodToInterval(Result.effective) + "eGFR Lab Frequency") < Today()
        else false
      end

define NeedsGFRSummary: 'Order Renal Lab Panel'

define NeedsGFRDetail:
	case
		when "CKD Stage" >= 1
			then 'eGFR lab recommended every ' + ToString("eGFR Lab Frequency") + ' for Stage ' + ToString("CKD Stage") + ' CKD.'
		when "Has CKD or Diabetes"
			then 'eGFR lab recommended every ' + ToString("eGFR Lab Frequency") + ' for CKD or Diabetes.'
		else null
	end

define NeedsGFRSeverity: 'info'

define "CKD Stage":
  "Last eGFR Quantity" egfr
  	return case
      when egfr.value < 15
    		then 5
    	when egfr.value < 30
    		then 4
    	when egfr.value < 60
    		then 3
    	when egfr.value < 90
    		then 2
    	when egfr.value >= 90
        // TODO this does not parse
        //case  when UACRtoMetric("Get UACR Quantity").value > 20
  		  //  then 1
        //else 0
        //end
        then 0
      else 0
  	end

// Referrals
//
define "Recommend Nephrology Referral":
	"5-Year Risk Level" = 'High'

define NephrologyReferralDetail: 'Referral to a nephrologist is recommended when 5-year risk is High'

define NephrologyReferralSeverity: 'info'

//
// Tangri CKD risk model
//
// 4 variable
// 1 – 0.9750 ^ exp (-0.2201 × (age/10 – 7.036) + 0.2467 × (male – 0.5642) – 0.5567 × (eGFR/5 – 7.222) + 0.4510 × (logACR – 5.137))
// 5 year factor =  0.9240
//
// 8 variable
// 1 – 0.9780 ^ exp (-0.1992 × (age/10 – 7.036) + 0.1602 × (male – 0.5642) – 0.4919 × (eGFR/5 – 7.222) + 0.3364 × (logACR – 5.137)
//		– 0.3441 × (albumin – 3.997) + 0.2604 × (phosphorous – 3.916) – 0.07354 × (bicarbonate – 25.57) – 0.2228 × (calcium – 9.355))
// 5 year factor = 0.9301

define "2-YearRiskDetail":
	'2-year kidney failure risk of ' + ToString("2-Year CKD Risk Percent") + '% is considered to be ' + "2-Year Risk Level" + ' risk.'

define "5-YearRiskDetail":
	'5-year kidney failure risk of ' + ToString("5-Year CKD Risk Percent") + '% is considered to be ' + "5-Year Risk Level" + ' risk.'

define "2-YearRiskSeverity": if "2-Year Risk Level" = 'High' then 'warning' else 'info'

define "5-YearRiskSeverity": if "5-Year Risk Level" = 'High' then 'warning' else 'info'

define "2-Year CKD Risk Percent":
  "2-Year CKD Risk" risk
    return Round(risk * 100, 2)

define "5-Year CKD Risk Percent":
  "5-Year CKD Risk" risk
    return Round(risk * 100, 2)

define "2-Year CKD Risk":
  "Last eGFR Quantity" egfr
    return calculateCkdRisk(0.9750, 0, AgeInYears(), egfr, UACRtoMetric("Last UACR Quantity"))

define "5-Year CKD Risk":
  "Last eGFR Quantity" egfr
    return calculateCkdRisk(0.9240, 0, AgeInYears(), egfr, UACRtoMetric("Last UACR Quantity"))

// The ckdFactor is a variable determined by (Non-) North American location and whether calculation is 2 or 5 year prediction
define function calculateCkdRisk(ckdFactor Decimal, sex Integer, age Integer, egfr System.Quantity, acr System.Quantity):
  1.0 - Power(ckdFactor, Exp(-0.2201 * (age / 10 - 7.036) + 0.2467 * (sex - 0.5642) - 0.5567 * (egfr.value / 5 - 7.222) + 0.4510 * (Ln(acr.value) - 5.137)))

define "2-Year Risk Level":
  "2-Year CKD Risk Percent" riskPercent
  	return case
      when riskPercent < 5
    		then 'Low'
    	when riskPercent < 15
    		then 'Intermediate'
    	when riskPercent > 15
    		then 'High'
      else null
  	end

define "5-Year Risk Level":
  "5-Year CKD Risk Percent" riskPercent
  	return case
      when riskPercent < 5
    		then 'Low'
    	when riskPercent < 15
    		then 'Intermediate'
    	when riskPercent > 15
    		then 'High'
      else null
  	end

// Conversion functions

define function PeriodToInterval(value FHIR.Period):
	Interval[value."start".value, value."end".value]

define function CodingToCode(coding FHIR.Coding):
	System.Code {
		code: coding.code.value,
		system: coding.system.value,
		version: coding.version.value,
		display: coding.display.value
	}

define function ToConcept(concept FHIR.CodeableConcept):
    System.Concept {
        codes: concept.coding C return CodingToCode(C),
        display: concept.text.value
    }

define function ToQuantity(quantity FHIR.Quantity):
    System.Quantity {
        value: quantity.value.value,
        unit: quantity.unit.value
    }

define function UACRtoMetric(qty System.Quantity):
	case when qty.unit = 'mg/mmol creatinine' then
		System.Quantity { value: qty.value * 8.84, unit: 'mg/g' }
	when qty.unit = 'mg/g' then
    qty
	else
    // unknown units, ignore this quantity in calculation
		null
	end

define function ToMetric(qty System.Quantity):
	case when qty.unit = 'lb' then
		System.Quantity { value: qty.value * 0.454, unit: 'kg' }
	when qty.unit = 'in' then
		System.Quantity { value: qty.value * 0.0254, unit: 'm' }
	else
		qty
	end
"
    }
  ]
}