Pharmaceutical Quality - Chemistry, Manufacturing and Controls (PQ-CMC) Submissions to FDA
2.0.0 - STU2 United States of America flag

This page is part of the Pharmaceutical Quality - Chemistry, Manufacturing and Controls (PQ-CMC) Submissions to FDA (v2.0.0: STU2) based on FHIR (HL7® FHIR® Standard) v5.0.0. This is the current published version. For a full list of available versions, see the Directory of published versions

Resource Profile: Drug Substance

Official URL: http://hl7.org/fhir/us/pq-cmc-fda/StructureDefinition/pqcmc-drug-substance-characterisation Version: 2.0.0
Standards status: Trial-use Maturity Level: 2 Computable Name: DrugSubstanceCharacterisation
Other Identifiers: OID:2.16.840.1.113883.4.642.40.36.42.48

Drug Substance (Active Ingredient) nomenclature and characterization.

Usages:

Formal Views of Profile Content

Description of Profiles, Differentials, Snapshots and how the different presentations work.

NameFlagsCard.TypeDescription & Constraints    Filter: Filtersdoco
.. SubstanceDefinition C 0..* SubstanceDefinition The detailed description of a substance, typically at a level beyond what is used for prescribing
Constraints: cmc-when-unii-required, cmc-name-isbt, cmc-substance-characterisation-content-required
... implicitRules ?!Σ 0..1 uri A set of rules under which this content was created
... contained 0..* Resource Contained, inline Resources
... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored
... classification SΣ 1..1 CodeableConcept Substance Type
Binding: Substance Classification (required)
... manufacturer SΣ 0..1 LiteralReference(Basic Organization) {b} The entity that creates, makes, produces or fabricates the substance
... supplier SΣ 0..1 LiteralReference(Basic Organization) {b} An entity that is the source for the substance. It may be different from the manufacturer
... characterization SΣ 0..* BackboneElement General specifications for this substance
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... technique SΣ 0..1 CodeableConceptTextOnly Substance Characterisation Technique
Binding: StructureTechnique (example): The method used to elucidate the characterization of the drug substance.
.... description SΣ 0..1 markdown Analysis Narrative Text and Table
.... Slices for file SΣ 0..* Attachment Impurity Analysis Graphic | Impurity Analytical Instrument Data File
Slice: Unordered, Open by profile:$this
..... file:AnalysisGraphic SΣ 0..* GraphicAttachment Analysis Graphic
..... file:AnalyticalInstrumentData SΣ 0..* AnalyticalInstrumentData Analytical Instrument Data File
... Slices for code SΣ 1..* BackboneElement Codes associated with the substance
Slice: Unordered, Open by value:code.coding.system
.... code:All Slices Content/Rules for all slices
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... code:unii SΣ 0..1 BackboneElement UNII
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... code SΣ 1..1 CodeableConcept The specific code
...... coding SΣ 1..1 Coding Code defined by a terminology system
....... system SΣ 1..1 uri Identity of the terminology system
Required Pattern: http://fdasis.nlm.nih.gov
.... code:uniProt SΣ 0..1 BackboneElement UniProt ID
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... code SΣ 1..1 CodeableConcept The specific code
...... coding SΣ 1..1 Coding Code defined by a terminology system
....... system SΣ 1..1 uri Identity of the terminology system
Required Pattern: http://terminology.hl7.org/NamingSystem/UniProt
... Slices for name SΣC 1..* BackboneElement Substance Name
Slice: Unordered, Closed by value:type
Constraints: cmc-name-preferred
.... name:All Slices Content/Rules for all slices
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name Σ 1..1 string The actual name
..... type Σ 0..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: Substance Name Type (required)
..... preferred SΣ 0..1 boolean True when the name type is Substance Name
.... name:sub SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Generic Name
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: Substance Name Type (required)
Required Pattern: At least the following
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C97054
....... display 1..1 string Representation defined by the system
Fixed Value: Generic Name
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text 0..1 string Plain text representation of the concept
..... preferred SΣ 0..1 boolean True when the name type is Substance Name
.... name:gsrs SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string GSRS Preferred Term
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: Substance Name Type (required)
Required Pattern: At least the following
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203355
....... display 1..1 string Representation defined by the system
Fixed Value: GSRS Preferred Term
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text 0..1 string Plain text representation of the concept
..... preferred SΣ 0..1 boolean True when the name type is Substance Name
.... name:isbt SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string ISBT-128 DIN
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: Substance Name Type (required)
Required Pattern: At least the following
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C95517
....... display 1..1 string Representation defined by the system
Fixed Value: ISBT-128 DIN
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text 0..1 string Plain text representation of the concept
..... preferred SΣ 0..1 boolean True when the name type is Substance Name
... relationship SΣ 0..* BackboneElement Reference to Drug Substance Impurity
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... substanceDefinition[x] SΣ 1..1 LiteralReference(Drug Substance Impurity) {b} A pointer to another substance, as a resource or a representational code
.... type Σ 1..1 CodeableConcept For example "salt to parent", "active moiety"
Binding: SubstanceRelationshipType (example): The relationship between two substance types.

doco Documentation for this format

Terminology Bindings

PathConformanceValueSet / CodeURI
SubstanceDefinition.classificationrequiredSubstanceClassification
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/substance-classification
From this IG
SubstanceDefinition.characterization.techniqueexampleStructureTechnique
http://hl7.org/fhir/ValueSet/substance-structure-technique
From the FHIR Standard
SubstanceDefinition.name.typerequiredPqcmcSubstanceNameType
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-substance-name-type
From this IG
SubstanceDefinition.name:sub.typerequiredPattern Value: C97054("Generic Name")
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-substance-name-type
From this IG
SubstanceDefinition.name:gsrs.typerequiredPattern Value: C203355("GSRS Preferred Term")
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-substance-name-type
From this IG
SubstanceDefinition.name:isbt.typerequiredPattern Value: C95517("ISBT-128 DIN")
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-substance-name-type
From this IG
SubstanceDefinition.relationship.typeexampleSubstanceRelationshipType
http://hl7.org/fhir/ValueSet/substance-relationship-type
From the FHIR Standard

Constraints

IdGradePath(s)DetailsRequirements
cmc-name-isbterrorSubstanceDefinitionName.type ISBT 128 required for blood products.
: classification.where(coding.where(code = '8' and system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl').exists()).exists() implies name.type.coding.exists(code = '226' and system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl')
cmc-name-preferrederrorSubstanceDefinition.nameName.preferred: at most one = true
: select(preferred = true).count() < 2
cmc-substance-characterisation-content-requirederrorSubstanceDefinitionDrug Substance Characterisation must contain at least one characterisation or at least one relationship
: characterization.exists() or relationship.exists()
cmc-when-unii-requirederrorSubstanceDefinitionA UNII is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer'. A UniProt code is required for any of these categories: 'Protein'
: (classification.coding.where(system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl' and (code in ('C48807' | 'C45305' | 'C706' | 'C48803'))).exists() implies code.where( code.coding.exists(system = 'http://fdasis.nlm.nih.gov') ).exists()) and (classification.coding.where( system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl' and code = 'C17021' ).exists() implies code.where( code.coding.exists(system = 'http://terminology.hl7.org/NamingSystem/UniProt') ).exists())
dom-2errorSubstanceDefinitionIf the resource is contained in another resource, it SHALL NOT contain nested Resources
: contained.contained.empty()
dom-3errorSubstanceDefinitionIf the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource
: contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().ofType(canonical) | %resource.descendants().ofType(uri) | %resource.descendants().ofType(url))) or descendants().where(reference = '#').exists() or descendants().where(ofType(canonical) = '#').exists() or descendants().where(ofType(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4errorSubstanceDefinitionIf a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated
: contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5errorSubstanceDefinitionIf a resource is contained in another resource, it SHALL NOT have a security label
: contained.meta.security.empty()
dom-6best practiceSubstanceDefinitionA resource should have narrative for robust management
: text.`div`.exists()
ele-1error**ALL** elementsAll FHIR elements must have a @value or children
: hasValue() or (children().count() > id.count())
ext-1error**ALL** extensionsMust have either extensions or value[x], not both
: extension.exists() != value.exists()

This structure is derived from SubstanceDefinition

NameFlagsCard.TypeDescription & Constraints    Filter: Filtersdoco
.. SubstanceDefinition C 0..* SubstanceDefinition The detailed description of a substance, typically at a level beyond what is used for prescribing
Constraints: cmc-when-unii-required, cmc-name-isbt, cmc-substance-characterisation-content-required
... identifier S 0..1 Identifier optional user designated identifier
... classification S 1..1 CodeableConcept Substance Type
Binding: Substance Classification (required)
... manufacturer S 0..1 LiteralReference(Basic Organization) {b} The entity that creates, makes, produces or fabricates the substance
... characterization S 0..* BackboneElement General specifications for this substance
.... technique S 0..1 CodeableConceptTextOnly Substance Characterisation Technique
.... description S 0..1 markdown Analysis Narrative Text and Table
.... Slices for file S 0..* Attachment Impurity Analysis Graphic | Impurity Analytical Instrument Data File
Slice: Unordered, Open by profile:$this
..... file:AnalysisGraphic S 0..* GraphicAttachment Analysis Graphic
..... file:AnalyticalInstrumentData S 0..* AnalyticalInstrumentData Analytical Instrument Data File
... Slices for code S 1..* BackboneElement Codes associated with the substance
Slice: Unordered, Open by value:code.coding.system
.... code:unii S 0..1 BackboneElement UNII
..... code S 1..1 CodeableConcept The specific code
...... coding S 1..1 Coding Code defined by a terminology system
....... system S 1..1 uri Identity of the terminology system
Required Pattern: http://fdasis.nlm.nih.gov
.... code:uniProt S 0..1 BackboneElement UniProt ID
..... code S 1..1 CodeableConcept The specific code
...... coding S 1..1 Coding Code defined by a terminology system
....... system S 1..1 uri Identity of the terminology system
Required Pattern: http://terminology.hl7.org/NamingSystem/UniProt
... Slices for name SC 1..* BackboneElement Substance Name
Slice: Unordered, Closed by value:type
Constraints: cmc-name-preferred
.... name:All Slices Content/Rules for all slices
..... type 0..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: Substance Name Type (required)
..... preferred S 0..1 boolean True when the name type is Substance Name
.... name:sub S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string Generic Name
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Required Pattern: At least the following
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C97054
....... display 1..1 string Representation defined by the system
Fixed Value: Generic Name
..... preferred S 0..1 boolean True when the name type is Substance Name
.... name:gsrs S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string GSRS Preferred Term
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Required Pattern: At least the following
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203355
....... display 1..1 string Representation defined by the system
Fixed Value: GSRS Preferred Term
..... preferred S 0..1 boolean True when the name type is Substance Name
.... name:isbt S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string ISBT-128 DIN
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Required Pattern: At least the following
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C95517
....... display 1..1 string Representation defined by the system
Fixed Value: ISBT-128 DIN
..... preferred S 0..1 boolean True when the name type is Substance Name
... relationship S 0..* BackboneElement Reference to Drug Substance Impurity
.... substanceDefinition[x] S 1..1 LiteralReference(Drug Substance Impurity) {b} A pointer to another substance, as a resource or a representational code

doco Documentation for this format

Terminology Bindings (Differential)

PathConformanceValueSetURI
SubstanceDefinition.classificationrequiredSubstanceClassification
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/substance-classification
From this IG
SubstanceDefinition.name.typerequiredPqcmcSubstanceNameType
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-substance-name-type
From this IG

Constraints

IdGradePath(s)DetailsRequirements
cmc-name-isbterrorSubstanceDefinitionName.type ISBT 128 required for blood products.
: classification.where(coding.where(code = '8' and system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl').exists()).exists() implies name.type.coding.exists(code = '226' and system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl')
cmc-name-preferrederrorSubstanceDefinition.nameName.preferred: at most one = true
: select(preferred = true).count() < 2
cmc-substance-characterisation-content-requirederrorSubstanceDefinitionDrug Substance Characterisation must contain at least one characterisation or at least one relationship
: characterization.exists() or relationship.exists()
cmc-when-unii-requirederrorSubstanceDefinitionA UNII is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer'. A UniProt code is required for any of these categories: 'Protein'
: (classification.coding.where(system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl' and (code in ('C48807' | 'C45305' | 'C706' | 'C48803'))).exists() implies code.where( code.coding.exists(system = 'http://fdasis.nlm.nih.gov') ).exists()) and (classification.coding.where( system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl' and code = 'C17021' ).exists() implies code.where( code.coding.exists(system = 'http://terminology.hl7.org/NamingSystem/UniProt') ).exists())
NameFlagsCard.TypeDescription & Constraints    Filter: Filtersdoco
.. SubstanceDefinition C 0..* SubstanceDefinition The detailed description of a substance, typically at a level beyond what is used for prescribing
Constraints: cmc-when-unii-required, cmc-name-isbt, cmc-substance-characterisation-content-required
... id Σ 0..1 id Logical id of this artifact
... meta Σ 0..1 Meta Metadata about the resource
... implicitRules ?!Σ 0..1 uri A set of rules under which this content was created
... language 0..1 code Language of the resource content
Binding: AllLanguages (required): IETF language tag for a human language
Additional BindingsPurpose
CommonLanguages Starter
... text 0..1 Narrative Text summary of the resource, for human interpretation
This profile does not constrain the narrative in regard to content, language, or traceability to data elements
... contained 0..* Resource Contained, inline Resources
... extension 0..* Extension Additional content defined by implementations
... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored
... identifier SΣ 0..1 Identifier optional user designated identifier
... version Σ 0..1 string A business level version identifier of the substance
... status Σ 0..1 CodeableConcept Status of substance within the catalogue e.g. active, retired
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
... classification SΣ 1..1 CodeableConcept Substance Type
Binding: Substance Classification (required)
... domain Σ 0..1 CodeableConcept If the substance applies to human or veterinary use
Binding: MedicinalProductDomain (example): Applicable domain for this product (e.g. human, veterinary).
... grade Σ 0..* CodeableConcept The quality standard, established benchmark, to which substance complies (e.g. USP/NF, BP)
Binding: SubstanceGrade (example): The quality standard, established benchmark, to which a substance complies
... description Σ 0..1 markdown Textual description of the substance
... informationSource Σ 0..* Reference(Citation) Supporting literature
... note Σ 0..* Annotation Textual comment about the substance's catalogue or registry record
... manufacturer SΣ 0..1 LiteralReference(Basic Organization) {b} The entity that creates, makes, produces or fabricates the substance
... supplier SΣ 0..1 LiteralReference(Basic Organization) {b} An entity that is the source for the substance. It may be different from the manufacturer
... moiety Σ 0..* BackboneElement Moiety, for structural modifications
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... role Σ 0..1 CodeableConcept Role that the moiety is playing
.... identifier Σ 0..1 Identifier Identifier by which this moiety substance is known
.... name Σ 0..1 string Textual name for this moiety substance
.... stereochemistry Σ 0..1 CodeableConcept Stereochemistry type
Binding: Stereochemistry (example): The optical rotation type of a substance.
.... opticalActivity Σ 0..1 CodeableConcept Optical activity type
Binding: OpticalActivity (example): The optical rotation type of a substance.
.... molecularFormula Σ 0..1 string Molecular formula for this moiety (e.g. with the Hill system)
.... amount[x] Σ 0..1 Quantitative value for this moiety
..... amountQuantity Quantity
..... amountString string
.... measurementType Σ 0..1 CodeableConcept The measurement type of the quantitative value
Binding: SubstanceAmountType (example): The relationship between two substance types.
... characterization SΣ 0..* BackboneElement General specifications for this substance
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... technique SΣ 0..1 CodeableConceptTextOnly Substance Characterisation Technique
Binding: StructureTechnique (example): The method used to elucidate the characterization of the drug substance.
.... form Σ 0..1 CodeableConcept Describes the nature of the chemical entity and explains, for instance, whether this is a base or a salt form
Binding: SubstanceForm (example)
.... description SΣ 0..1 markdown Analysis Narrative Text and Table
.... Slices for file SΣ 0..* Attachment Impurity Analysis Graphic | Impurity Analytical Instrument Data File
Slice: Unordered, Open by profile:$this
..... file:AnalysisGraphic SΣ 0..* GraphicAttachment Analysis Graphic
..... file:AnalyticalInstrumentData SΣ 0..* AnalyticalInstrumentData Analytical Instrument Data File
... property Σ 0..* BackboneElement General specifications for this substance
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... type Σ 1..1 CodeableConcept A code expressing the type of property
Binding: ProductCharacteristic (example): This value set includes all observable entity codes from SNOMED CT - provided as an exemplar value set.
.... value[x] Σ 0..1 A value for the property
..... valueCodeableConcept CodeableConcept
..... valueQuantity Quantity
..... valueDate date
..... valueBoolean boolean
..... valueAttachment Attachment
... referenceInformation Σ 0..1 Reference(SubstanceReferenceInformation) General information detailing this substance
... molecularWeight Σ 0..* BackboneElement The average mass of a molecule of a compound
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... method Σ 0..1 CodeableConcept The method by which the weight was determined
Binding: WeightMethod (example): The method by which the substance weight was measured.
.... type Σ 0..1 CodeableConcept Type of molecular weight e.g. exact, average, weight average
Binding: WeightType (example): The type of substance weight measurement.
.... amount Σ 1..1 Quantity Used to capture quantitative values for a variety of elements
... structure Σ 0..1 BackboneElement Structural information
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... stereochemistry Σ 0..1 CodeableConcept Stereochemistry type
Binding: Stereochemistry (example): The optical rotation type of a substance.
.... opticalActivity Σ 0..1 CodeableConcept Optical activity type
Binding: OpticalActivity (example): The optical rotation type of a substance.
.... molecularFormula Σ 0..1 string An expression which states the number and type of atoms present in a molecule of a substance
.... molecularFormulaByMoiety Σ 0..1 string Specified per moiety according to the Hill system
.... molecularWeight Σ 0..1 See molecularWeight (SubstanceDefinition) The molecular weight or weight range
.... technique Σ 0..* CodeableConcept The method used to find the structure e.g. X-ray, NMR
Binding: StructureTechnique (example): The method used to elucidate the structure of the drug substance.
.... sourceDocument Σ 0..* Reference(DocumentReference) Source of information for the structure
.... representation Σ 0..* BackboneElement A depiction of the structure of the substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... type Σ 0..1 CodeableConcept The kind of structural representation (e.g. full, partial)
Binding: SubstanceRepresentationType (example): A format of a substance representation.
..... representation Σ 0..1 string The structural representation as a text string in a standard format
..... format Σ 0..1 CodeableConcept The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format)
Binding: SubstanceRepresentationFormat (example): A format of a substance representation.
..... document Σ 0..1 Reference(DocumentReference) An attachment with the structural representation e.g. a structure graphic or AnIML file
... Slices for code SΣ 1..* BackboneElement Codes associated with the substance
Slice: Unordered, Open by value:code.coding.system
.... code:All Slices Content/Rules for all slices
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... code Σ 0..1 CodeableConcept The specific code
..... status Σ 0..1 CodeableConcept Status of the code assignment, for example 'provisional', 'approved'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
..... statusDate Σ 0..1 dateTime The date at which the code status was changed
..... note Σ 0..* Annotation Any comment can be provided in this field
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... code:unii SΣ 0..1 BackboneElement UNII
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... code SΣ 1..1 CodeableConcept The specific code
...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system
....... id 0..1 id Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
....... system SΣ 1..1 uri Identity of the terminology system
Required Pattern: http://fdasis.nlm.nih.gov
....... version Σ 0..1 string Version of the system - if relevant
....... code ΣC 0..1 code Symbol in syntax defined by the system
....... display ΣC 0..1 string Representation defined by the system
....... userSelected Σ 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept Status of the code assignment, for example 'provisional', 'approved'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
..... statusDate Σ 0..1 dateTime The date at which the code status was changed
..... note Σ 0..* Annotation Any comment can be provided in this field
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... code:uniProt SΣ 0..1 BackboneElement UniProt ID
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... code SΣ 1..1 CodeableConcept The specific code
...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system
....... id 0..1 id Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
....... system SΣ 1..1 uri Identity of the terminology system
Required Pattern: http://terminology.hl7.org/NamingSystem/UniProt
....... version Σ 0..1 string Version of the system - if relevant
....... code ΣC 0..1 code Symbol in syntax defined by the system
....... display ΣC 0..1 string Representation defined by the system
....... userSelected Σ 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept Status of the code assignment, for example 'provisional', 'approved'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
..... statusDate Σ 0..1 dateTime The date at which the code status was changed
..... note Σ 0..* Annotation Any comment can be provided in this field
..... source Σ 0..* Reference(DocumentReference) Supporting literature
... Slices for name SΣC 1..* BackboneElement Substance Name
Slice: Unordered, Closed by value:type
Constraints: cmc-name-preferred
.... name:All Slices Content/Rules for all slices
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name Σ 1..1 string The actual name
..... type Σ 0..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: Substance Name Type (required)
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
..... preferred SΣ 0..1 boolean True when the name type is Substance Name
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language
Additional BindingsPurpose
CommonLanguages Starter

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.
..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes
..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.
...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:sub SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Generic Name
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: Substance Name Type (required)
Required Pattern: At least the following
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C97054
....... display 1..1 string Representation defined by the system
Fixed Value: Generic Name
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
..... preferred SΣ 0..1 boolean True when the name type is Substance Name
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language
Additional BindingsPurpose
CommonLanguages Starter

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.
..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes
..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.
...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:gsrs SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string GSRS Preferred Term
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: Substance Name Type (required)
Required Pattern: At least the following
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203355
....... display 1..1 string Representation defined by the system
Fixed Value: GSRS Preferred Term
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
..... preferred SΣ 0..1 boolean True when the name type is Substance Name
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language
Additional BindingsPurpose
CommonLanguages Starter

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.
..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes
..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.
...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:isbt SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string ISBT-128 DIN
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: Substance Name Type (required)
Required Pattern: At least the following
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C95517
....... display 1..1 string Representation defined by the system
Fixed Value: ISBT-128 DIN
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
..... preferred SΣ 0..1 boolean True when the name type is Substance Name
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language
Additional BindingsPurpose
CommonLanguages Starter

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.
..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes
..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.
...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
... relationship SΣ 0..* BackboneElement Reference to Drug Substance Impurity
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... substanceDefinition[x] SΣ 1..1 LiteralReference(Drug Substance Impurity) {b} A pointer to another substance, as a resource or a representational code
.... type Σ 1..1 CodeableConcept For example "salt to parent", "active moiety"
Binding: SubstanceRelationshipType (example): The relationship between two substance types.
.... isDefining Σ 0..1 boolean For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships
.... amount[x] Σ 0..1 A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other
..... amountQuantity Quantity
..... amountRatio Ratio
..... amountString string
.... ratioHighLimitAmount Σ 0..1 Ratio For use when the numeric has an uncertain range
.... comparator Σ 0..1 CodeableConcept An operator for the amount, for example "average", "approximately", "less than"
Binding: SubstanceAmountType (example): The relationship between two substance types.
.... source Σ 0..* Reference(DocumentReference) Supporting literature
... nucleicAcid Σ 0..1 Reference(SubstanceNucleicAcid) Data items specific to nucleic acids
... polymer Σ 0..1 Reference(SubstancePolymer) Data items specific to polymers
... protein Σ 0..1 Reference(SubstanceProtein) Data items specific to proteins
... sourceMaterial Σ 0..1 BackboneElement Material or taxonomic/anatomical source
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... type Σ 0..1 CodeableConcept Classification of the origin of the raw material. e.g. cat hair is an Animal source type
Binding: SourceMaterialType (example): A classification that provides the origin of the substance raw material.
.... genus Σ 0..1 CodeableConcept The genus of an organism e.g. the Latin epithet of the plant/animal scientific name
Binding: SourceMaterialGenus (example): The genus of an organism, typically referring to the Latin epithet of the genus element of the plant/animal scientific name.
.... species Σ 0..1 CodeableConcept The species of an organism e.g. the Latin epithet of the species of the plant/animal
Binding: SourceMaterialSpecies (example): A species of origin a substance raw material.
.... part Σ 0..1 CodeableConcept An anatomical origin of the source material within an organism
Binding: SourceMaterialPart (example): An anatomical origin of the source material within an organism.
.... countryOfOrigin Σ 0..* CodeableConcept The country or countries where the material is harvested
Binding: CountryValueSet (required): Jurisdiction codes

doco Documentation for this format

Terminology Bindings

PathConformanceValueSet / CodeURI
SubstanceDefinition.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
From the FHIR Standard
SubstanceDefinition.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
From the FHIR Standard
SubstanceDefinition.classificationrequiredSubstanceClassification
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/substance-classification
From this IG
SubstanceDefinition.domainexampleMedicinalProductDomain
http://hl7.org/fhir/ValueSet/medicinal-product-domain
From the FHIR Standard
SubstanceDefinition.gradeexampleSubstanceGrade
http://hl7.org/fhir/ValueSet/substance-grade
From the FHIR Standard
SubstanceDefinition.moiety.stereochemistryexampleStereochemistry
http://hl7.org/fhir/ValueSet/substance-stereochemistry
From the FHIR Standard
SubstanceDefinition.moiety.opticalActivityexampleOpticalActivity
http://hl7.org/fhir/ValueSet/substance-optical-activity
From the FHIR Standard
SubstanceDefinition.moiety.measurementTypeexampleSubstanceAmountType
http://hl7.org/fhir/ValueSet/substance-amount-type
From the FHIR Standard
SubstanceDefinition.characterization.techniqueexampleStructureTechnique
http://hl7.org/fhir/ValueSet/substance-structure-technique
From the FHIR Standard
SubstanceDefinition.characterization.formexampleSubstanceForm
http://hl7.org/fhir/ValueSet/substance-form
From the FHIR Standard
SubstanceDefinition.property.typeexampleProductCharacteristic
http://hl7.org/fhir/ValueSet/product-characteristic-codes
From the FHIR Standard
SubstanceDefinition.molecularWeight.methodexampleWeightMethod
http://hl7.org/fhir/ValueSet/substance-weight-method
From the FHIR Standard
SubstanceDefinition.molecularWeight.typeexampleWeightType
http://hl7.org/fhir/ValueSet/substance-weight-type
From the FHIR Standard
SubstanceDefinition.structure.stereochemistryexampleStereochemistry
http://hl7.org/fhir/ValueSet/substance-stereochemistry
From the FHIR Standard
SubstanceDefinition.structure.opticalActivityexampleOpticalActivity
http://hl7.org/fhir/ValueSet/substance-optical-activity
From the FHIR Standard
SubstanceDefinition.structure.techniqueexampleStructureTechnique
http://hl7.org/fhir/ValueSet/substance-structure-technique
From the FHIR Standard
SubstanceDefinition.structure.representation.typeexampleSubstanceRepresentationType
http://hl7.org/fhir/ValueSet/substance-representation-type
From the FHIR Standard
SubstanceDefinition.structure.representation.formatexampleSubstanceRepresentationFormat
http://hl7.org/fhir/ValueSet/substance-representation-format
From the FHIR Standard
SubstanceDefinition.code.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
From the FHIR Standard
SubstanceDefinition.code:unii.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
From the FHIR Standard
SubstanceDefinition.code:uniProt.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
From the FHIR Standard
SubstanceDefinition.name.typerequiredPqcmcSubstanceNameType
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-substance-name-type
From this IG
SubstanceDefinition.name.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
From the FHIR Standard
SubstanceDefinition.name.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
From the FHIR Standard
SubstanceDefinition.name.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
From the FHIR Standard
SubstanceDefinition.name.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
From the FHIR Standard
SubstanceDefinition.name.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
From the FHIR Standard
SubstanceDefinition.name.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
From the FHIR Standard
SubstanceDefinition.name:sub.typerequiredPattern Value: C97054("Generic Name")
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-substance-name-type
From this IG
SubstanceDefinition.name:sub.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
From the FHIR Standard
SubstanceDefinition.name:sub.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
From the FHIR Standard
SubstanceDefinition.name:sub.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
From the FHIR Standard
SubstanceDefinition.name:sub.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
From the FHIR Standard
SubstanceDefinition.name:sub.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
From the FHIR Standard
SubstanceDefinition.name:sub.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
From the FHIR Standard
SubstanceDefinition.name:gsrs.typerequiredPattern Value: C203355("GSRS Preferred Term")
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-substance-name-type
From this IG
SubstanceDefinition.name:gsrs.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
From the FHIR Standard
SubstanceDefinition.name:gsrs.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
From the FHIR Standard
SubstanceDefinition.name:gsrs.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
From the FHIR Standard
SubstanceDefinition.name:gsrs.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
From the FHIR Standard
SubstanceDefinition.name:gsrs.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
From the FHIR Standard
SubstanceDefinition.name:gsrs.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
From the FHIR Standard
SubstanceDefinition.name:isbt.typerequiredPattern Value: C95517("ISBT-128 DIN")
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-substance-name-type
From this IG
SubstanceDefinition.name:isbt.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
From the FHIR Standard
SubstanceDefinition.name:isbt.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
From the FHIR Standard
SubstanceDefinition.name:isbt.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
From the FHIR Standard
SubstanceDefinition.name:isbt.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
From the FHIR Standard
SubstanceDefinition.name:isbt.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
From the FHIR Standard
SubstanceDefinition.name:isbt.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
From the FHIR Standard
SubstanceDefinition.relationship.typeexampleSubstanceRelationshipType
http://hl7.org/fhir/ValueSet/substance-relationship-type
From the FHIR Standard
SubstanceDefinition.relationship.comparatorexampleSubstanceAmountType
http://hl7.org/fhir/ValueSet/substance-amount-type
From the FHIR Standard
SubstanceDefinition.sourceMaterial.typeexampleSourceMaterialType
http://hl7.org/fhir/ValueSet/substance-source-material-type
From the FHIR Standard
SubstanceDefinition.sourceMaterial.genusexampleSourceMaterialGenus
http://hl7.org/fhir/ValueSet/substance-source-material-genus
From the FHIR Standard
SubstanceDefinition.sourceMaterial.speciesexampleSourceMaterialSpecies
http://hl7.org/fhir/ValueSet/substance-source-material-species
From the FHIR Standard
SubstanceDefinition.sourceMaterial.partexampleSourceMaterialPart
http://hl7.org/fhir/ValueSet/substance-source-material-part
From the FHIR Standard
SubstanceDefinition.sourceMaterial.countryOfOriginrequiredCountryValueSet
http://hl7.org/fhir/ValueSet/country|5.0.0
From the FHIR Standard

Constraints

IdGradePath(s)DetailsRequirements
cmc-name-isbterrorSubstanceDefinitionName.type ISBT 128 required for blood products.
: classification.where(coding.where(code = '8' and system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl').exists()).exists() implies name.type.coding.exists(code = '226' and system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl')
cmc-name-preferrederrorSubstanceDefinition.nameName.preferred: at most one = true
: select(preferred = true).count() < 2
cmc-substance-characterisation-content-requirederrorSubstanceDefinitionDrug Substance Characterisation must contain at least one characterisation or at least one relationship
: characterization.exists() or relationship.exists()
cmc-when-unii-requirederrorSubstanceDefinitionA UNII is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer'. A UniProt code is required for any of these categories: 'Protein'
: (classification.coding.where(system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl' and (code in ('C48807' | 'C45305' | 'C706' | 'C48803'))).exists() implies code.where( code.coding.exists(system = 'http://fdasis.nlm.nih.gov') ).exists()) and (classification.coding.where( system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl' and code = 'C17021' ).exists() implies code.where( code.coding.exists(system = 'http://terminology.hl7.org/NamingSystem/UniProt') ).exists())
dom-2errorSubstanceDefinitionIf the resource is contained in another resource, it SHALL NOT contain nested Resources
: contained.contained.empty()
dom-3errorSubstanceDefinitionIf the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource
: contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().ofType(canonical) | %resource.descendants().ofType(uri) | %resource.descendants().ofType(url))) or descendants().where(reference = '#').exists() or descendants().where(ofType(canonical) = '#').exists() or descendants().where(ofType(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4errorSubstanceDefinitionIf a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated
: contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5errorSubstanceDefinitionIf a resource is contained in another resource, it SHALL NOT have a security label
: contained.meta.security.empty()
dom-6best practiceSubstanceDefinitionA resource should have narrative for robust management
: text.`div`.exists()
ele-1error**ALL** elementsAll FHIR elements must have a @value or children
: hasValue() or (children().count() > id.count())
ext-1error**ALL** extensionsMust have either extensions or value[x], not both
: extension.exists() != value.exists()

This structure is derived from SubstanceDefinition

Summary

Mandatory: 3 elements(10 nested mandatory elements)
Must-Support: 35 elements

Structures

This structure refers to these other structures:

Slices

This structure defines the following Slices:

  • The element 1 is sliced based on the value of SubstanceDefinition.characterization.file
  • The element 1 is sliced based on the value of SubstanceDefinition.code
  • The element 1 is sliced based on the value of SubstanceDefinition.name (Closed)

Maturity: 2

Key Elements View

NameFlagsCard.TypeDescription & Constraints    Filter: Filtersdoco
.. SubstanceDefinition C 0..* SubstanceDefinition The detailed description of a substance, typically at a level beyond what is used for prescribing
Constraints: cmc-when-unii-required, cmc-name-isbt, cmc-substance-characterisation-content-required
... implicitRules ?!Σ 0..1 uri A set of rules under which this content was created
... contained 0..* Resource Contained, inline Resources
... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored
... classification SΣ 1..1 CodeableConcept Substance Type
Binding: Substance Classification (required)
... manufacturer SΣ 0..1 LiteralReference(Basic Organization) {b} The entity that creates, makes, produces or fabricates the substance
... supplier SΣ 0..1 LiteralReference(Basic Organization) {b} An entity that is the source for the substance. It may be different from the manufacturer
... characterization SΣ 0..* BackboneElement General specifications for this substance
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... technique SΣ 0..1 CodeableConceptTextOnly Substance Characterisation Technique
Binding: StructureTechnique (example): The method used to elucidate the characterization of the drug substance.
.... description SΣ 0..1 markdown Analysis Narrative Text and Table
.... Slices for file SΣ 0..* Attachment Impurity Analysis Graphic | Impurity Analytical Instrument Data File
Slice: Unordered, Open by profile:$this
..... file:AnalysisGraphic SΣ 0..* GraphicAttachment Analysis Graphic
..... file:AnalyticalInstrumentData SΣ 0..* AnalyticalInstrumentData Analytical Instrument Data File
... Slices for code SΣ 1..* BackboneElement Codes associated with the substance
Slice: Unordered, Open by value:code.coding.system
.... code:All Slices Content/Rules for all slices
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... code:unii SΣ 0..1 BackboneElement UNII
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... code SΣ 1..1 CodeableConcept The specific code
...... coding SΣ 1..1 Coding Code defined by a terminology system
....... system SΣ 1..1 uri Identity of the terminology system
Required Pattern: http://fdasis.nlm.nih.gov
.... code:uniProt SΣ 0..1 BackboneElement UniProt ID
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... code SΣ 1..1 CodeableConcept The specific code
...... coding SΣ 1..1 Coding Code defined by a terminology system
....... system SΣ 1..1 uri Identity of the terminology system
Required Pattern: http://terminology.hl7.org/NamingSystem/UniProt
... Slices for name SΣC 1..* BackboneElement Substance Name
Slice: Unordered, Closed by value:type
Constraints: cmc-name-preferred
.... name:All Slices Content/Rules for all slices
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name Σ 1..1 string The actual name
..... type Σ 0..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: Substance Name Type (required)
..... preferred SΣ 0..1 boolean True when the name type is Substance Name
.... name:sub SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Generic Name
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: Substance Name Type (required)
Required Pattern: At least the following
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C97054
....... display 1..1 string Representation defined by the system
Fixed Value: Generic Name
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text 0..1 string Plain text representation of the concept
..... preferred SΣ 0..1 boolean True when the name type is Substance Name
.... name:gsrs SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string GSRS Preferred Term
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: Substance Name Type (required)
Required Pattern: At least the following
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203355
....... display 1..1 string Representation defined by the system
Fixed Value: GSRS Preferred Term
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text 0..1 string Plain text representation of the concept
..... preferred SΣ 0..1 boolean True when the name type is Substance Name
.... name:isbt SΣ 0..1 BackboneElement Names applicable to this substance
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string ISBT-128 DIN
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: Substance Name Type (required)
Required Pattern: At least the following
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C95517
....... display 1..1 string Representation defined by the system
Fixed Value: ISBT-128 DIN
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text 0..1 string Plain text representation of the concept
..... preferred SΣ 0..1 boolean True when the name type is Substance Name
... relationship SΣ 0..* BackboneElement Reference to Drug Substance Impurity
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... substanceDefinition[x] SΣ 1..1 LiteralReference(Drug Substance Impurity) {b} A pointer to another substance, as a resource or a representational code
.... type Σ 1..1 CodeableConcept For example "salt to parent", "active moiety"
Binding: SubstanceRelationshipType (example): The relationship between two substance types.

doco Documentation for this format

Terminology Bindings

PathConformanceValueSet / CodeURI
SubstanceDefinition.classificationrequiredSubstanceClassification
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/substance-classification
From this IG
SubstanceDefinition.characterization.techniqueexampleStructureTechnique
http://hl7.org/fhir/ValueSet/substance-structure-technique
From the FHIR Standard
SubstanceDefinition.name.typerequiredPqcmcSubstanceNameType
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-substance-name-type
From this IG
SubstanceDefinition.name:sub.typerequiredPattern Value: C97054("Generic Name")
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-substance-name-type
From this IG
SubstanceDefinition.name:gsrs.typerequiredPattern Value: C203355("GSRS Preferred Term")
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-substance-name-type
From this IG
SubstanceDefinition.name:isbt.typerequiredPattern Value: C95517("ISBT-128 DIN")
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-substance-name-type
From this IG
SubstanceDefinition.relationship.typeexampleSubstanceRelationshipType
http://hl7.org/fhir/ValueSet/substance-relationship-type
From the FHIR Standard

Constraints

IdGradePath(s)DetailsRequirements
cmc-name-isbterrorSubstanceDefinitionName.type ISBT 128 required for blood products.
: classification.where(coding.where(code = '8' and system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl').exists()).exists() implies name.type.coding.exists(code = '226' and system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl')
cmc-name-preferrederrorSubstanceDefinition.nameName.preferred: at most one = true
: select(preferred = true).count() < 2
cmc-substance-characterisation-content-requirederrorSubstanceDefinitionDrug Substance Characterisation must contain at least one characterisation or at least one relationship
: characterization.exists() or relationship.exists()
cmc-when-unii-requirederrorSubstanceDefinitionA UNII is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer'. A UniProt code is required for any of these categories: 'Protein'
: (classification.coding.where(system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl' and (code in ('C48807' | 'C45305' | 'C706' | 'C48803'))).exists() implies code.where( code.coding.exists(system = 'http://fdasis.nlm.nih.gov') ).exists()) and (classification.coding.where( system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl' and code = 'C17021' ).exists() implies code.where( code.coding.exists(system = 'http://terminology.hl7.org/NamingSystem/UniProt') ).exists())
dom-2errorSubstanceDefinitionIf the resource is contained in another resource, it SHALL NOT contain nested Resources
: contained.contained.empty()
dom-3errorSubstanceDefinitionIf the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource
: contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().ofType(canonical) | %resource.descendants().ofType(uri) | %resource.descendants().ofType(url))) or descendants().where(reference = '#').exists() or descendants().where(ofType(canonical) = '#').exists() or descendants().where(ofType(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4errorSubstanceDefinitionIf a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated
: contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5errorSubstanceDefinitionIf a resource is contained in another resource, it SHALL NOT have a security label
: contained.meta.security.empty()
dom-6best practiceSubstanceDefinitionA resource should have narrative for robust management
: text.`div`.exists()
ele-1error**ALL** elementsAll FHIR elements must have a @value or children
: hasValue() or (children().count() > id.count())
ext-1error**ALL** extensionsMust have either extensions or value[x], not both
: extension.exists() != value.exists()

Differential View

This structure is derived from SubstanceDefinition

NameFlagsCard.TypeDescription & Constraints    Filter: Filtersdoco
.. SubstanceDefinition C 0..* SubstanceDefinition The detailed description of a substance, typically at a level beyond what is used for prescribing
Constraints: cmc-when-unii-required, cmc-name-isbt, cmc-substance-characterisation-content-required
... identifier S 0..1 Identifier optional user designated identifier
... classification S 1..1 CodeableConcept Substance Type
Binding: Substance Classification (required)
... manufacturer S 0..1 LiteralReference(Basic Organization) {b} The entity that creates, makes, produces or fabricates the substance
... characterization S 0..* BackboneElement General specifications for this substance
.... technique S 0..1 CodeableConceptTextOnly Substance Characterisation Technique
.... description S 0..1 markdown Analysis Narrative Text and Table
.... Slices for file S 0..* Attachment Impurity Analysis Graphic | Impurity Analytical Instrument Data File
Slice: Unordered, Open by profile:$this
..... file:AnalysisGraphic S 0..* GraphicAttachment Analysis Graphic
..... file:AnalyticalInstrumentData S 0..* AnalyticalInstrumentData Analytical Instrument Data File
... Slices for code S 1..* BackboneElement Codes associated with the substance
Slice: Unordered, Open by value:code.coding.system
.... code:unii S 0..1 BackboneElement UNII
..... code S 1..1 CodeableConcept The specific code
...... coding S 1..1 Coding Code defined by a terminology system
....... system S 1..1 uri Identity of the terminology system
Required Pattern: http://fdasis.nlm.nih.gov
.... code:uniProt S 0..1 BackboneElement UniProt ID
..... code S 1..1 CodeableConcept The specific code
...... coding S 1..1 Coding Code defined by a terminology system
....... system S 1..1 uri Identity of the terminology system
Required Pattern: http://terminology.hl7.org/NamingSystem/UniProt
... Slices for name SC 1..* BackboneElement Substance Name
Slice: Unordered, Closed by value:type
Constraints: cmc-name-preferred
.... name:All Slices Content/Rules for all slices
..... type 0..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: Substance Name Type (required)
..... preferred S 0..1 boolean True when the name type is Substance Name
.... name:sub S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string Generic Name
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Required Pattern: At least the following
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C97054
....... display 1..1 string Representation defined by the system
Fixed Value: Generic Name
..... preferred S 0..1 boolean True when the name type is Substance Name
.... name:gsrs S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string GSRS Preferred Term
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Required Pattern: At least the following
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203355
....... display 1..1 string Representation defined by the system
Fixed Value: GSRS Preferred Term
..... preferred S 0..1 boolean True when the name type is Substance Name
.... name:isbt S 0..1 BackboneElement Names applicable to this substance
..... name S 1..1 string ISBT-128 DIN
..... type S 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Required Pattern: At least the following
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C95517
....... display 1..1 string Representation defined by the system
Fixed Value: ISBT-128 DIN
..... preferred S 0..1 boolean True when the name type is Substance Name
... relationship S 0..* BackboneElement Reference to Drug Substance Impurity
.... substanceDefinition[x] S 1..1 LiteralReference(Drug Substance Impurity) {b} A pointer to another substance, as a resource or a representational code

doco Documentation for this format

Terminology Bindings (Differential)

PathConformanceValueSetURI
SubstanceDefinition.classificationrequiredSubstanceClassification
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/substance-classification
From this IG
SubstanceDefinition.name.typerequiredPqcmcSubstanceNameType
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-substance-name-type
From this IG

Constraints

IdGradePath(s)DetailsRequirements
cmc-name-isbterrorSubstanceDefinitionName.type ISBT 128 required for blood products.
: classification.where(coding.where(code = '8' and system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl').exists()).exists() implies name.type.coding.exists(code = '226' and system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl')
cmc-name-preferrederrorSubstanceDefinition.nameName.preferred: at most one = true
: select(preferred = true).count() < 2
cmc-substance-characterisation-content-requirederrorSubstanceDefinitionDrug Substance Characterisation must contain at least one characterisation or at least one relationship
: characterization.exists() or relationship.exists()
cmc-when-unii-requirederrorSubstanceDefinitionA UNII is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer'. A UniProt code is required for any of these categories: 'Protein'
: (classification.coding.where(system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl' and (code in ('C48807' | 'C45305' | 'C706' | 'C48803'))).exists() implies code.where( code.coding.exists(system = 'http://fdasis.nlm.nih.gov') ).exists()) and (classification.coding.where( system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl' and code = 'C17021' ).exists() implies code.where( code.coding.exists(system = 'http://terminology.hl7.org/NamingSystem/UniProt') ).exists())

Snapshot View

NameFlagsCard.TypeDescription & Constraints    Filter: Filtersdoco
.. SubstanceDefinition C 0..* SubstanceDefinition The detailed description of a substance, typically at a level beyond what is used for prescribing
Constraints: cmc-when-unii-required, cmc-name-isbt, cmc-substance-characterisation-content-required
... id Σ 0..1 id Logical id of this artifact
... meta Σ 0..1 Meta Metadata about the resource
... implicitRules ?!Σ 0..1 uri A set of rules under which this content was created
... language 0..1 code Language of the resource content
Binding: AllLanguages (required): IETF language tag for a human language
Additional BindingsPurpose
CommonLanguages Starter
... text 0..1 Narrative Text summary of the resource, for human interpretation
This profile does not constrain the narrative in regard to content, language, or traceability to data elements
... contained 0..* Resource Contained, inline Resources
... extension 0..* Extension Additional content defined by implementations
... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored
... identifier SΣ 0..1 Identifier optional user designated identifier
... version Σ 0..1 string A business level version identifier of the substance
... status Σ 0..1 CodeableConcept Status of substance within the catalogue e.g. active, retired
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
... classification SΣ 1..1 CodeableConcept Substance Type
Binding: Substance Classification (required)
... domain Σ 0..1 CodeableConcept If the substance applies to human or veterinary use
Binding: MedicinalProductDomain (example): Applicable domain for this product (e.g. human, veterinary).
... grade Σ 0..* CodeableConcept The quality standard, established benchmark, to which substance complies (e.g. USP/NF, BP)
Binding: SubstanceGrade (example): The quality standard, established benchmark, to which a substance complies
... description Σ 0..1 markdown Textual description of the substance
... informationSource Σ 0..* Reference(Citation) Supporting literature
... note Σ 0..* Annotation Textual comment about the substance's catalogue or registry record
... manufacturer SΣ 0..1 LiteralReference(Basic Organization) {b} The entity that creates, makes, produces or fabricates the substance
... supplier SΣ 0..1 LiteralReference(Basic Organization) {b} An entity that is the source for the substance. It may be different from the manufacturer
... moiety Σ 0..* BackboneElement Moiety, for structural modifications
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... role Σ 0..1 CodeableConcept Role that the moiety is playing
.... identifier Σ 0..1 Identifier Identifier by which this moiety substance is known
.... name Σ 0..1 string Textual name for this moiety substance
.... stereochemistry Σ 0..1 CodeableConcept Stereochemistry type
Binding: Stereochemistry (example): The optical rotation type of a substance.
.... opticalActivity Σ 0..1 CodeableConcept Optical activity type
Binding: OpticalActivity (example): The optical rotation type of a substance.
.... molecularFormula Σ 0..1 string Molecular formula for this moiety (e.g. with the Hill system)
.... amount[x] Σ 0..1 Quantitative value for this moiety
..... amountQuantity Quantity
..... amountString string
.... measurementType Σ 0..1 CodeableConcept The measurement type of the quantitative value
Binding: SubstanceAmountType (example): The relationship between two substance types.
... characterization SΣ 0..* BackboneElement General specifications for this substance
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... technique SΣ 0..1 CodeableConceptTextOnly Substance Characterisation Technique
Binding: StructureTechnique (example): The method used to elucidate the characterization of the drug substance.
.... form Σ 0..1 CodeableConcept Describes the nature of the chemical entity and explains, for instance, whether this is a base or a salt form
Binding: SubstanceForm (example)
.... description SΣ 0..1 markdown Analysis Narrative Text and Table
.... Slices for file SΣ 0..* Attachment Impurity Analysis Graphic | Impurity Analytical Instrument Data File
Slice: Unordered, Open by profile:$this
..... file:AnalysisGraphic SΣ 0..* GraphicAttachment Analysis Graphic
..... file:AnalyticalInstrumentData SΣ 0..* AnalyticalInstrumentData Analytical Instrument Data File
... property Σ 0..* BackboneElement General specifications for this substance
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... type Σ 1..1 CodeableConcept A code expressing the type of property
Binding: ProductCharacteristic (example): This value set includes all observable entity codes from SNOMED CT - provided as an exemplar value set.
.... value[x] Σ 0..1 A value for the property
..... valueCodeableConcept CodeableConcept
..... valueQuantity Quantity
..... valueDate date
..... valueBoolean boolean
..... valueAttachment Attachment
... referenceInformation Σ 0..1 Reference(SubstanceReferenceInformation) General information detailing this substance
... molecularWeight Σ 0..* BackboneElement The average mass of a molecule of a compound
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... method Σ 0..1 CodeableConcept The method by which the weight was determined
Binding: WeightMethod (example): The method by which the substance weight was measured.
.... type Σ 0..1 CodeableConcept Type of molecular weight e.g. exact, average, weight average
Binding: WeightType (example): The type of substance weight measurement.
.... amount Σ 1..1 Quantity Used to capture quantitative values for a variety of elements
... structure Σ 0..1 BackboneElement Structural information
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... stereochemistry Σ 0..1 CodeableConcept Stereochemistry type
Binding: Stereochemistry (example): The optical rotation type of a substance.
.... opticalActivity Σ 0..1 CodeableConcept Optical activity type
Binding: OpticalActivity (example): The optical rotation type of a substance.
.... molecularFormula Σ 0..1 string An expression which states the number and type of atoms present in a molecule of a substance
.... molecularFormulaByMoiety Σ 0..1 string Specified per moiety according to the Hill system
.... molecularWeight Σ 0..1 See molecularWeight (SubstanceDefinition) The molecular weight or weight range
.... technique Σ 0..* CodeableConcept The method used to find the structure e.g. X-ray, NMR
Binding: StructureTechnique (example): The method used to elucidate the structure of the drug substance.
.... sourceDocument Σ 0..* Reference(DocumentReference) Source of information for the structure
.... representation Σ 0..* BackboneElement A depiction of the structure of the substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... type Σ 0..1 CodeableConcept The kind of structural representation (e.g. full, partial)
Binding: SubstanceRepresentationType (example): A format of a substance representation.
..... representation Σ 0..1 string The structural representation as a text string in a standard format
..... format Σ 0..1 CodeableConcept The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format)
Binding: SubstanceRepresentationFormat (example): A format of a substance representation.
..... document Σ 0..1 Reference(DocumentReference) An attachment with the structural representation e.g. a structure graphic or AnIML file
... Slices for code SΣ 1..* BackboneElement Codes associated with the substance
Slice: Unordered, Open by value:code.coding.system
.... code:All Slices Content/Rules for all slices
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... code Σ 0..1 CodeableConcept The specific code
..... status Σ 0..1 CodeableConcept Status of the code assignment, for example 'provisional', 'approved'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
..... statusDate Σ 0..1 dateTime The date at which the code status was changed
..... note Σ 0..* Annotation Any comment can be provided in this field
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... code:unii SΣ 0..1 BackboneElement UNII
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... code SΣ 1..1 CodeableConcept The specific code
...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system
....... id 0..1 id Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
....... system SΣ 1..1 uri Identity of the terminology system
Required Pattern: http://fdasis.nlm.nih.gov
....... version Σ 0..1 string Version of the system - if relevant
....... code ΣC 0..1 code Symbol in syntax defined by the system
....... display ΣC 0..1 string Representation defined by the system
....... userSelected Σ 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept Status of the code assignment, for example 'provisional', 'approved'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
..... statusDate Σ 0..1 dateTime The date at which the code status was changed
..... note Σ 0..* Annotation Any comment can be provided in this field
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... code:uniProt SΣ 0..1 BackboneElement UniProt ID
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... code SΣ 1..1 CodeableConcept The specific code
...... id 0..1 id Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
...... coding SΣ 1..1 Coding Code defined by a terminology system
....... id 0..1 id Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
Slice: Unordered, Open by value:url
....... system SΣ 1..1 uri Identity of the terminology system
Required Pattern: http://terminology.hl7.org/NamingSystem/UniProt
....... version Σ 0..1 string Version of the system - if relevant
....... code ΣC 0..1 code Symbol in syntax defined by the system
....... display ΣC 0..1 string Representation defined by the system
....... userSelected Σ 0..1 boolean If this coding was chosen directly by the user
...... text Σ 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept Status of the code assignment, for example 'provisional', 'approved'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
..... statusDate Σ 0..1 dateTime The date at which the code status was changed
..... note Σ 0..* Annotation Any comment can be provided in this field
..... source Σ 0..* Reference(DocumentReference) Supporting literature
... Slices for name SΣC 1..* BackboneElement Substance Name
Slice: Unordered, Closed by value:type
Constraints: cmc-name-preferred
.... name:All Slices Content/Rules for all slices
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name Σ 1..1 string The actual name
..... type Σ 0..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: Substance Name Type (required)
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
..... preferred SΣ 0..1 boolean True when the name type is Substance Name
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language
Additional BindingsPurpose
CommonLanguages Starter

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.
..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes
..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.
...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:sub SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string Generic Name
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: Substance Name Type (required)
Required Pattern: At least the following
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C97054
....... display 1..1 string Representation defined by the system
Fixed Value: Generic Name
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
..... preferred SΣ 0..1 boolean True when the name type is Substance Name
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language
Additional BindingsPurpose
CommonLanguages Starter

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.
..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes
..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.
...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:gsrs SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string GSRS Preferred Term
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: Substance Name Type (required)
Required Pattern: At least the following
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C203355
....... display 1..1 string Representation defined by the system
Fixed Value: GSRS Preferred Term
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
..... preferred SΣ 0..1 boolean True when the name type is Substance Name
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language
Additional BindingsPurpose
CommonLanguages Starter

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.
..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes
..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.
...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
.... name:isbt SΣ 0..1 BackboneElement Names applicable to this substance
..... id 0..1 string Unique id for inter-element referencing
..... extension 0..* Extension Additional content defined by implementations
..... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
..... name SΣ 1..1 string ISBT-128 DIN
..... type SΣ 1..1 CodeableConcept Name type e.g. 'systematic', 'scientific, 'brand'
Binding: Substance Name Type (required)
Required Pattern: At least the following
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... coding 1..* Coding Code defined by a terminology system
Fixed Value: (complex)
....... id 0..1 string Unique id for inter-element referencing
....... extension 0..* Extension Additional content defined by implementations
....... system 1..1 uri Identity of the terminology system
Fixed Value: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl
....... version 0..1 string Version of the system - if relevant
....... code 1..1 code Symbol in syntax defined by the system
Fixed Value: C95517
....... display 1..1 string Representation defined by the system
Fixed Value: ISBT-128 DIN
....... userSelected 0..1 boolean If this coding was chosen directly by the user
...... text 0..1 string Plain text representation of the concept
..... status Σ 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
..... preferred SΣ 0..1 boolean True when the name type is Substance Name
..... language Σ 0..* CodeableConcept Human language that the name is written in
Binding: AllLanguages (required): IETF language tag for a human language
Additional BindingsPurpose
CommonLanguages Starter

..... domain Σ 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive
Binding: SubstanceNameDomain (example): The use context of a substance name for example if there is a different name when used as a drug active ingredient as opposed to a food colour additive.
..... jurisdiction Σ 0..* CodeableConcept The jurisdiction where this name applies
Binding: JurisdictionValueSet (example): Jurisdiction codes
..... synonym Σ 0..* See name (SubstanceDefinition) A synonym of this particular name, by which the substance is also known
..... translation Σ 0..* See name (SubstanceDefinition) A translation for this name into another human language
..... official Σ 0..* BackboneElement Details of the official nature of this name
...... id 0..1 string Unique id for inter-element referencing
...... extension 0..* Extension Additional content defined by implementations
...... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
...... authority Σ 0..1 CodeableConcept Which authority uses this official name
Binding: SubstanceNameAuthority (preferred): An authority that officates substance names.
...... status Σ 0..1 CodeableConcept The status of the official name, for example 'draft', 'active'
Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
...... date Σ 0..1 dateTime Date of official name change
..... source Σ 0..* Reference(DocumentReference) Supporting literature
... relationship SΣ 0..* BackboneElement Reference to Drug Substance Impurity
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... substanceDefinition[x] SΣ 1..1 LiteralReference(Drug Substance Impurity) {b} A pointer to another substance, as a resource or a representational code
.... type Σ 1..1 CodeableConcept For example "salt to parent", "active moiety"
Binding: SubstanceRelationshipType (example): The relationship between two substance types.
.... isDefining Σ 0..1 boolean For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships
.... amount[x] Σ 0..1 A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other
..... amountQuantity Quantity
..... amountRatio Ratio
..... amountString string
.... ratioHighLimitAmount Σ 0..1 Ratio For use when the numeric has an uncertain range
.... comparator Σ 0..1 CodeableConcept An operator for the amount, for example "average", "approximately", "less than"
Binding: SubstanceAmountType (example): The relationship between two substance types.
.... source Σ 0..* Reference(DocumentReference) Supporting literature
... nucleicAcid Σ 0..1 Reference(SubstanceNucleicAcid) Data items specific to nucleic acids
... polymer Σ 0..1 Reference(SubstancePolymer) Data items specific to polymers
... protein Σ 0..1 Reference(SubstanceProtein) Data items specific to proteins
... sourceMaterial Σ 0..1 BackboneElement Material or taxonomic/anatomical source
.... id 0..1 string Unique id for inter-element referencing
.... extension 0..* Extension Additional content defined by implementations
.... modifierExtension ?!Σ 0..* Extension Extensions that cannot be ignored even if unrecognized
.... type Σ 0..1 CodeableConcept Classification of the origin of the raw material. e.g. cat hair is an Animal source type
Binding: SourceMaterialType (example): A classification that provides the origin of the substance raw material.
.... genus Σ 0..1 CodeableConcept The genus of an organism e.g. the Latin epithet of the plant/animal scientific name
Binding: SourceMaterialGenus (example): The genus of an organism, typically referring to the Latin epithet of the genus element of the plant/animal scientific name.
.... species Σ 0..1 CodeableConcept The species of an organism e.g. the Latin epithet of the species of the plant/animal
Binding: SourceMaterialSpecies (example): A species of origin a substance raw material.
.... part Σ 0..1 CodeableConcept An anatomical origin of the source material within an organism
Binding: SourceMaterialPart (example): An anatomical origin of the source material within an organism.
.... countryOfOrigin Σ 0..* CodeableConcept The country or countries where the material is harvested
Binding: CountryValueSet (required): Jurisdiction codes

doco Documentation for this format

Terminology Bindings

PathConformanceValueSet / CodeURI
SubstanceDefinition.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
From the FHIR Standard
SubstanceDefinition.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
From the FHIR Standard
SubstanceDefinition.classificationrequiredSubstanceClassification
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/substance-classification
From this IG
SubstanceDefinition.domainexampleMedicinalProductDomain
http://hl7.org/fhir/ValueSet/medicinal-product-domain
From the FHIR Standard
SubstanceDefinition.gradeexampleSubstanceGrade
http://hl7.org/fhir/ValueSet/substance-grade
From the FHIR Standard
SubstanceDefinition.moiety.stereochemistryexampleStereochemistry
http://hl7.org/fhir/ValueSet/substance-stereochemistry
From the FHIR Standard
SubstanceDefinition.moiety.opticalActivityexampleOpticalActivity
http://hl7.org/fhir/ValueSet/substance-optical-activity
From the FHIR Standard
SubstanceDefinition.moiety.measurementTypeexampleSubstanceAmountType
http://hl7.org/fhir/ValueSet/substance-amount-type
From the FHIR Standard
SubstanceDefinition.characterization.techniqueexampleStructureTechnique
http://hl7.org/fhir/ValueSet/substance-structure-technique
From the FHIR Standard
SubstanceDefinition.characterization.formexampleSubstanceForm
http://hl7.org/fhir/ValueSet/substance-form
From the FHIR Standard
SubstanceDefinition.property.typeexampleProductCharacteristic
http://hl7.org/fhir/ValueSet/product-characteristic-codes
From the FHIR Standard
SubstanceDefinition.molecularWeight.methodexampleWeightMethod
http://hl7.org/fhir/ValueSet/substance-weight-method
From the FHIR Standard
SubstanceDefinition.molecularWeight.typeexampleWeightType
http://hl7.org/fhir/ValueSet/substance-weight-type
From the FHIR Standard
SubstanceDefinition.structure.stereochemistryexampleStereochemistry
http://hl7.org/fhir/ValueSet/substance-stereochemistry
From the FHIR Standard
SubstanceDefinition.structure.opticalActivityexampleOpticalActivity
http://hl7.org/fhir/ValueSet/substance-optical-activity
From the FHIR Standard
SubstanceDefinition.structure.techniqueexampleStructureTechnique
http://hl7.org/fhir/ValueSet/substance-structure-technique
From the FHIR Standard
SubstanceDefinition.structure.representation.typeexampleSubstanceRepresentationType
http://hl7.org/fhir/ValueSet/substance-representation-type
From the FHIR Standard
SubstanceDefinition.structure.representation.formatexampleSubstanceRepresentationFormat
http://hl7.org/fhir/ValueSet/substance-representation-format
From the FHIR Standard
SubstanceDefinition.code.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
From the FHIR Standard
SubstanceDefinition.code:unii.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
From the FHIR Standard
SubstanceDefinition.code:uniProt.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
From the FHIR Standard
SubstanceDefinition.name.typerequiredPqcmcSubstanceNameType
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-substance-name-type
From this IG
SubstanceDefinition.name.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
From the FHIR Standard
SubstanceDefinition.name.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
From the FHIR Standard
SubstanceDefinition.name.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
From the FHIR Standard
SubstanceDefinition.name.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
From the FHIR Standard
SubstanceDefinition.name.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
From the FHIR Standard
SubstanceDefinition.name.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
From the FHIR Standard
SubstanceDefinition.name:sub.typerequiredPattern Value: C97054("Generic Name")
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-substance-name-type
From this IG
SubstanceDefinition.name:sub.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
From the FHIR Standard
SubstanceDefinition.name:sub.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
From the FHIR Standard
SubstanceDefinition.name:sub.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
From the FHIR Standard
SubstanceDefinition.name:sub.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
From the FHIR Standard
SubstanceDefinition.name:sub.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
From the FHIR Standard
SubstanceDefinition.name:sub.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
From the FHIR Standard
SubstanceDefinition.name:gsrs.typerequiredPattern Value: C203355("GSRS Preferred Term")
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-substance-name-type
From this IG
SubstanceDefinition.name:gsrs.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
From the FHIR Standard
SubstanceDefinition.name:gsrs.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
From the FHIR Standard
SubstanceDefinition.name:gsrs.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
From the FHIR Standard
SubstanceDefinition.name:gsrs.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
From the FHIR Standard
SubstanceDefinition.name:gsrs.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
From the FHIR Standard
SubstanceDefinition.name:gsrs.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
From the FHIR Standard
SubstanceDefinition.name:isbt.typerequiredPattern Value: C95517("ISBT-128 DIN")
http://hl7.org/fhir/us/pq-cmc-fda/ValueSet/pqcmc-substance-name-type
From this IG
SubstanceDefinition.name:isbt.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
From the FHIR Standard
SubstanceDefinition.name:isbt.languagerequiredAllLanguages
http://hl7.org/fhir/ValueSet/all-languages|5.0.0
From the FHIR Standard
SubstanceDefinition.name:isbt.domainexampleSubstanceNameDomain
http://hl7.org/fhir/ValueSet/substance-name-domain
From the FHIR Standard
SubstanceDefinition.name:isbt.jurisdictionexampleJurisdictionValueSet
http://hl7.org/fhir/ValueSet/jurisdiction
From the FHIR Standard
SubstanceDefinition.name:isbt.official.authoritypreferredSubstanceNameAuthority
http://hl7.org/fhir/ValueSet/substance-name-authority
From the FHIR Standard
SubstanceDefinition.name:isbt.official.statuspreferredPublicationStatus
http://hl7.org/fhir/ValueSet/publication-status
From the FHIR Standard
SubstanceDefinition.relationship.typeexampleSubstanceRelationshipType
http://hl7.org/fhir/ValueSet/substance-relationship-type
From the FHIR Standard
SubstanceDefinition.relationship.comparatorexampleSubstanceAmountType
http://hl7.org/fhir/ValueSet/substance-amount-type
From the FHIR Standard
SubstanceDefinition.sourceMaterial.typeexampleSourceMaterialType
http://hl7.org/fhir/ValueSet/substance-source-material-type
From the FHIR Standard
SubstanceDefinition.sourceMaterial.genusexampleSourceMaterialGenus
http://hl7.org/fhir/ValueSet/substance-source-material-genus
From the FHIR Standard
SubstanceDefinition.sourceMaterial.speciesexampleSourceMaterialSpecies
http://hl7.org/fhir/ValueSet/substance-source-material-species
From the FHIR Standard
SubstanceDefinition.sourceMaterial.partexampleSourceMaterialPart
http://hl7.org/fhir/ValueSet/substance-source-material-part
From the FHIR Standard
SubstanceDefinition.sourceMaterial.countryOfOriginrequiredCountryValueSet
http://hl7.org/fhir/ValueSet/country|5.0.0
From the FHIR Standard

Constraints

IdGradePath(s)DetailsRequirements
cmc-name-isbterrorSubstanceDefinitionName.type ISBT 128 required for blood products.
: classification.where(coding.where(code = '8' and system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl').exists()).exists() implies name.type.coding.exists(code = '226' and system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl')
cmc-name-preferrederrorSubstanceDefinition.nameName.preferred: at most one = true
: select(preferred = true).count() < 2
cmc-substance-characterisation-content-requirederrorSubstanceDefinitionDrug Substance Characterisation must contain at least one characterisation or at least one relationship
: characterization.exists() or relationship.exists()
cmc-when-unii-requirederrorSubstanceDefinitionA UNII is required in code for any of these categories: 'Chemical', 'Mixture', 'Nucleic Acids','Polymer'. A UniProt code is required for any of these categories: 'Protein'
: (classification.coding.where(system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl' and (code in ('C48807' | 'C45305' | 'C706' | 'C48803'))).exists() implies code.where( code.coding.exists(system = 'http://fdasis.nlm.nih.gov') ).exists()) and (classification.coding.where( system = 'http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl' and code = 'C17021' ).exists() implies code.where( code.coding.exists(system = 'http://terminology.hl7.org/NamingSystem/UniProt') ).exists())
dom-2errorSubstanceDefinitionIf the resource is contained in another resource, it SHALL NOT contain nested Resources
: contained.contained.empty()
dom-3errorSubstanceDefinitionIf the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource
: contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().ofType(canonical) | %resource.descendants().ofType(uri) | %resource.descendants().ofType(url))) or descendants().where(reference = '#').exists() or descendants().where(ofType(canonical) = '#').exists() or descendants().where(ofType(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4errorSubstanceDefinitionIf a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated
: contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5errorSubstanceDefinitionIf a resource is contained in another resource, it SHALL NOT have a security label
: contained.meta.security.empty()
dom-6best practiceSubstanceDefinitionA resource should have narrative for robust management
: text.`div`.exists()
ele-1error**ALL** elementsAll FHIR elements must have a @value or children
: hasValue() or (children().count() > id.count())
ext-1error**ALL** extensionsMust have either extensions or value[x], not both
: extension.exists() != value.exists()

This structure is derived from SubstanceDefinition

Summary

Mandatory: 3 elements(10 nested mandatory elements)
Must-Support: 35 elements

Structures

This structure refers to these other structures:

Slices

This structure defines the following Slices:

  • The element 1 is sliced based on the value of SubstanceDefinition.characterization.file
  • The element 1 is sliced based on the value of SubstanceDefinition.code
  • The element 1 is sliced based on the value of SubstanceDefinition.name (Closed)

Maturity: 2

 

Other representations of profile: CSV, Excel, Schematron