For many readers, the notion that physical activity is important to healthcare outcomes, and that prescribing increased physical activity will
improve healthcare outcomes may be taken as a given. However, for those who are interested in some of the supporting research (perhaps to help
make the case for implementing this implementation guide in their own organization), this page provides more detail about existing evidence,
complete with citations.
NOTE: These references are largely U.S.-centric, however the conclusions are generally applicable to other countries, though the statistics
may differ somewhat.
Physical Activity and Health
Being regularly physically active is one of the most important health behaviors people can engage in to maintain physical health, mental health,
and well-being.1 Regular physical activity (PA) is both health-promoting and important for disease treatment and
prevention with numerous benefits that contribute to a disability-free lifespan.2 New research shows that more than
110,000 lives could be saved annually if adults in the U.S. increased their PA by just ten minutes per day.3
However, to achieve this, policy makers and change leaders need to implement broad-reaching, evidence-based, equity-focused strategies
(including policy and systems changes), increasing access to community spaces and infrastructure for PA , and inclusion of PA assessment,
prescription, and referral into electronic health records and health care delivery for optimal patient care in the US.4
To further promote equitable access to the benefits of regular PA, policy and systems changes should address barriers like cost, access, time,
and accessibility.4
PA reduces the risk of several of the leading causes of death and disability, including cardiovascular disease and colon, breast,
and endometrial cancers.4, 5 PA is also important for improving outcomes for the approximately 2/3 of
Americans who have a chronic condition. For example, PA improves survival from breast cancer6 and
several aspects of quality of life for a broader range of cancers.7 Despite the many benefits of PA,
we know that youth PA decreased during the COVID-19 pandemic.8 The overall prevalence of physical
inactivity among adults in our nation is alarmingly high (25.3 percent), and significant disparities exist among race/ethnic groups (e.g.,
non-Hispanic Asian adults, 20.1 percent; non-Hispanic White, 23.0 percent; non-Hispanic American Indian/Alaska Native, 29.1 percent; non-Hispanic
Black, 30.0 percent; and Hispanic adults, 32.1 percent).9
A systematic literature review indicated that physically active adults when diagnosed with COVID-19 have decreased risk of severe clinical outcomes.10
Other studies show that PA is associated with strong immune response, risk reduction
from community-acquired infectious disease and mortality, and increased vaccine potency.11, 12,
13,14
During the pandemic, the U.S. saw anxiety increase 4-5 times and depression increased 2-5 times pre-pandemic monthly averages.15
An umbrella review of 97 systematic reviews and meta-analyses concluded that PA should be part of standard care for anxiety, depression, and psychological distress
as it is highly beneficial for improving symptoms for all adults, including those with pre-existing mental health disorders and those with chronic disease.16
Regular PA also contributes to social connectedness, quality of life, and environmental sustainability.17
Currently in the U.S., only 26 percent of men, 19 percent of women, and 20 percent of adolescents report sufficient activity to meet the relevant
guidelines for aerobic and muscle-strengthening activities.1 Even so, current population PA levels avert 3.9 million premature deaths globally and
140,200 premature deaths in the U.S. on an annual basis.18
If all Americans met current PA guidelines,
Medicare could save $73.9 billion per year.19 In one study of older adults including over 50,000 patients, total
average healthcare expenses were significantly reduced by 16% for fitness program participants compared to non-participating Medicare Advantage
members.20 The study's findings showed total annual average health expenses, including medical and pharmacy, among program
participants to be $4,463 compared to $5,303 for non-participants. The medical component of costs was decreased by 26%, driven primarily by reductions in hospitalization costs. Use
of outpatient care was higher for participants combined with less acute care, indicating better health management among participants compared to
non-participants. Participants also performed significantly better on key quality measures including all-cause 30-day readmissions, adherence to
hypertension and cholesterol medications, diabetes care (HbA1c testing and eye exams), and many preventive screening measures including colonoscopy,
depression, cholesterol, breast cancer, and prostate cancer screening when compared to non-participants.20
Low PA and low fitness pose immediate and long-term threats to our nation’s safety and security. At this time, 71 percent of Americans ages 17-24
fail to meet core eligibility requirements for entrance into the military, creating a serious recruiting deficit.21
Among those who do meet basic requirements for service, musculoskeletal injuries associated with low fitness levels have costed the Department of
Defense hundreds of millions of dollars,22 and have been identified as the most significant medical impediment to
military readiness.23
Importance of Measuring Physical Activity
Despite the abundance of evidence on the importance of PA for individuals of all ages, races and abilities,1
our current healthcare system lacks a set of standardized measures for PA that can be incorporated into electronic medical/health records
and easily utilized by clinicians.2 As a result, millions of Americans lack appropriate counseling and
prescription for active living that would prevent or manage most of the chronic diseases and their associated risk factors, some infectious diseases,
and improve mental health and well-being.
Improving population levels of PA requires comprehensive efforts to maximize the potential benefits of setting-specific interventions
under a coordinated multilevel approach across the healthcare system and community and home-based resources.24,
25 Numerous guidelines and recommendations, including the Physical Activity Guidelines for Americans,1
the US Preventive Services Task Force,26 the Healthy People 2030 Framework,27 the US
National Physical Activity Plan,28 and the World Health Organization Guidelines on Physical Activity28
promote the importance of PA assessment, prescription, and referral as a standard of care in clinical practice.
In response to common barriers to effectively deliver complex PA counseling solely in clinical settings, programs have integrated referral of patients
to community-based PA resources and programs.25 These exercise referral schemes have also shown
effectiveness.30, 31 Compared with usual care, more patients who received referrals for exercise by
their primary care providers achieved PA recommendations (relative risk, 1.16), and experienced reduced depression.31
Heath and colleagues32 examined the feasibility of a clinic-based Physical Activity Vital Sign (PAVS) assessment and
referral protocol to YMCA exercise programming compared with PAVS alone in a sample of adult patients seen for primary care visits in a southeastern
US health system. They found improvements in self-reported PA after 12 weeks in the PAVS plus referral group (P<0.02).32 The specific exercise
vital sign measure proposed for this implementation guide has been tested and found to correctly identify the majority of adults and children/adolescents (5-18 years) who do and do not meet
PA guidelines.33,34 Other meta-analyses and
systematic reviews have shown that physician counseling (odds ratio, 1.42; 95% confidence interval, 1.17–1.73) and exercise referral systems (risk
ratio, 1.20; 95% confidence interval, 1.06–1.35) promote improvements in patients’ PA for up to 12 months.31, 35,
36
Citations
- 1. US Department of Health and Human Services. Physical Activity Guidelines for Americans, 2nd edition. 2018.https://health.gov/sites/default/files/2019-09/Physical_Activity_Guidelines_2nd_edition.pdf
- 2. Wen CP and Wu X. Stressing harms of physical inactivity to promote exercise. Lancet. 2012;380:192-3.https://doi.org/10.1016/S0140-6736(12)60954-4
- 3. Saint-Maurice, PF., Graubard, BI., Troiano, RP., Berrigan, D., Galuska, DA., Fulton, JE., Matthews, CE. Estimated number of deaths prevented through increased physical activity among US adults. JAMA Intern Med. 2022 March 1; 182(3); 349-352.https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2788473
- 4. Jerome GJ, Boyer WR, Bustamante EE, Kariuki J, Lopez-Jimenez F, Paluch AE, Swift DL, Webber-Ritchey KJ, Gibbs BB. Increasing Equity of Physical Activity Promotion for Optimal Cardiovascular Health in Adults: A Scientific Statement From the American Heart Association. Circulation. 2023;147:1951-1962. https://doi.org/10.1161/CIR.0000000000001148
- 5. American Institute for Cancer Research/ World Cancer Research Fund. Continuous Update Project: Physical Activity. 2020. Available at https://www.aicr.org/research/the-continuous-update-project/physical-activity.
- 6. American Institute for Cancer Research/ World Cancer Research Fund. Continuous Update Project: Breast Cancer Survivorship. 2020. Available at https://www.aicr.org/research/the-continuous-update-project/breast-cancer-survivorship.
- 7. Rock, CL., Thomson, CA., Sullivan, KR., et al. American Cancer Society nutrition and physical activity guideline for cancer survivors. Ca Cancer J Clin 2022; https://acsjournals.onlinelibrary.wiley.com/doi/10.3322/caac.21719
- 8. Grimes, A., Lightner, JS., Eighmy, K., Steel, C., Shook, RP., Carlson, J. Decreased physical activity among youth resulting from COVID-19 pandemic related school closures: Natural experimental study. JMIR Form Res.2022 Apr; 6(4):e35854.https://formative.jmir.org/2022/4/e35854/
- 9. Centers for Disease Control and Prevention. Adult physical inactivity prevalence maps by race/ethnicity. January 2022. Atlanta, GA. Accessed online June 17, 2022 at Adult Physical Inactivity Prevalence Maps by Race/Ethnicity | Physical Activity | CDC
- 10. Hill, AL., Whitfield, G., Morford, M., Okasako-Schmucker, DL., et al. Brief summary of findings on the association between physical inactivity and severe COVID-19 outcomes. Centers for Disease Control and Prevention. Atlanta, Georgia. 2022. https://www.cdc.gov/coronavirus/2019-ncov/downloads/clinical-care/E-Physical-Inactivity-Review.pdf.
- 11. Nieman DC, Wentz LM. The compelling link between physical activity and the body’s
defense system. J Sport Heal Sci. Published online 2019. doi:10.1016/j.jshs.2018.09.009.
- 12. Hamer M, Kivimäki M, Gale CR, David Batty G. Lifestyle risk factors, inflammatory mechanisms, and COVID-19 hospitalization: A community-based cohort study of 387,109 adults in UK. Brain Behav Immun. 2020;87:184-87. Epub 2020 May 23. https://www.sciencedirect.com/science/article/pii/S088915912030996X?via%3Dihub
- 13. Dixit S. Can moderate intensity aerobic exercise be an effective and valuable therapy in preventing and controlling the pandemic of COVID-19? Med Hypotheses. 2020;143:109854. Epub 2020 May 20. https://www.sciencedirect.com/science/article/pii/S0306987720307660?via%3Dihub
- 14. Webber BJ, Yun HC, Whitfield GP. Leisure-time physical activity and mortality from influenza and pneumonia: a cohort study of 577 909 US adults. Br J Sports Med. 2023 May 16:bjsports-2022-106644. doi: 10.1136/bjsports-2022-106644. Epub ahead of print. PMID: 37192831.
- 15. DeAngelis, T. (2021, November 1). Depression and anxiety escalate during COVID. Monitor on Psychology, 52(8). https://www.apa.org/monitor/2021/11/numbers-depression-anxiety
- 16. Singh B, Olds T, Curtis R, Dumuid D, Virgara R, Watson A, Szeto K, O'Connor E, Ferguson T, Eglitis E, Miatke A, Simpson CEM, Maher C. Effectiveness of physical activity interventions for improving depression, anxiety and distress: an overview of systematic reviews. British Journal of Sports Medicine, 2023; bjsports-2022-106195 DOI: 10.1136/bjsports-2022-106195
- 17. Global Advocacy Council for Physical Activity International Society for Physical A and Health. The Toronto Charter for Physical Activity: A Global Call for Action. J Phys Act Health. 2010;7 Suppl 3:S370-85. https://journals.humankinetics.com/view/journals/jpah/7/s3/article-pS370.xml
- 18. Strain T, Brage, S., Sharp, SJ., Richards, J., Tainio, M., Ding, D., Benichou, J., Kelly, P. Use of the prevented fraction for the population to determine deaths averted by existing prevalence of physical activity: a descriptive study. Lancet Global Health. 2020;8:e920-30.https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(20)30211-4/fulltext
- 19. HHS FY2016 Budget in Brief, https://www.hhs.gov/about/budget/budget-in-brief/cms/medicare/index.html.
- 20. SilverSneakers Program Impact Analysis, independent study conducted by the Health Economics and Advanced Analytics Practice at Avalere Health on behalf of Tivity Health, March 2021.https://www.tivityhealth.com/wp-content/uploads/2021/04/Avalere-SilverSneakers-Cost-Study-Full-Deck_Avalere-Updated-4-26-21.pdf
- 21. U.S. Department of Defense, Joint Advertising Market Research and Studies. (2016). The target population for military recruitment: youth eligible to enlist without a waiver. https://dacowits.defense.gov/Portals/48/Documents/General%20Documents/RFI%20Docs/Sept2016/JAMRS%20RFI%2014.pdf?ver=2016-09-09-164855-510.
- 22. Bulzacchelli M, Sulsky S, Zhu L, Brandt S, Barenberg A. The cost of basic combat training injuries in the U.S. Army: injury-related medical care and risk factors. In: Military Performance Division, U.S. Army Research Institute of Environmental Medicine. Edited by Natick MA, March 2017.https://apps.dtic.mil/dtic/tr/fulltext/u2/1050457.pdf
- 23. Hauret KG, Jones BH, Bullock SH, Canham-Chervak M, Canada S. Musculoskeletal injuries description of an under-recognized injury problem among military personnel. AmJ Prev Med. Jan 2010; 38(1)(suppl):S61–S70.https://linkinghub.elsevier.com/retrieve/pii/S0749-3797(09)00674-6
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- 26. US Preventive Services Task Force. Draft Recommendation Statement on Behavioral Counseling to Promote a Healthy Lifestyle in Adults with Cardiovascular Risk Factors. 2020.https://pubmed.ncbi.nlm.nih.gov/33231670/
- 27. Office of Disease Prevention and Health Promotion. US Department of Health and Human Services. Healthy People 2030 Framework. 2020. Healthy People 2030 | health.gov
- 28. National Physical Activity Plan. 2016. National Physical Activity Plan - PAA https://paamovewithus.org.
- 29. World Health Organization. Physical Activity. https://www.who.int/news-room/fact-sheets/detail/physical-activity. 2022. Accessed 06/19/2023.
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- 31. Pavey TG, Taylor AH, Fox KR, Hillsdon M, Anokye N, Campbell JL, Foster C, Green C, Moxham T, Mutrie N, Searle J, Trueman P, Taylor RS. Effect of exercise referral schemes in primary care on physical activity and improving health outcomes: systematic review and meta-analysis. BMJ. 2011;343:d6462.https://www.bmj.com/content/343/bmj.d6462.long
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- 33. Kuntz, J. L., Young, D. R., Saelens, B. E., Frank, L. D., Meenan, R. T., Dickerson, J. F., Keast, E. M., & Fortmann, S. P. (2021). Validity of the Exercise Vital Sign Tool to Assess Physical Activity. American journal of preventive medicine, 60(6), 866–872. doi:10.1016/j.amepre.2021.01.012
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- 35. Sanchez A, Bully P, Martinez C, Grandes G. Effectiveness of physical activity promotion interventions in primary care: A review of reviews. Prev Med. 2015;76(suppl):S56–S67. doi:10.1016/j.ypmed.2014.09.012.
- 36. Orrow G, Kinmonth AL, Sanderson S, Sutton S. Effectiveness of physical activity promotion based in primary care: systematic review and metaanalysis of randomised controlled trials. BMJ. 2012;344:e1389.https://www.bmj.com/content/344/bmj.e1389.long.