minimal Common Oncology Data Elements (mCODE) Implementation Guide
3.0.0 - STU3 Release United States of America flag

This page is part of the HL7 FHIR Implementation Guide: minimal Common Oncology Data Elements (mCODE) Release 1 - US Realm | STU1 (v3.0.0: STU 3) based on FHIR R4. This is the current published version. For a full list of available versions, see the Directory of published versions

: gx-genomic-bundle-adam-anyperson - XML Representation

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<Bundle xmlns="http://hl7.org/fhir">
  <id value="gx-genomic-bundle-adam-anyperson"/>
  <type value="collection"/>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Patient/gx-cancer-patient-adam-anyperson"/>
    <resource>
      <Patient>
        <id value="gx-cancer-patient-adam-anyperson"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-cancer-patient"/>
        </meta>
        <text>
          <status value="extensions"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Patient</b><a name="gx-cancer-patient-adam-anyperson"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Patient &quot;gx-cancer-patient-adam-anyperson&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-mcode-cancer-patient.html">Cancer Patient Profile</a></p></div><p><b>US Core Birth Sex Extension</b>: M</p><p><b>identifier</b>: Patient external identifier: 22ea1d1b-03a5-47d6-81e0-b9b4cbb15ccf (use: USUAL), Medical Record Number: 123456789</p><p><b>name</b>: Adam Anyperson </p><p><b>gender</b>: male</p><p><b>birthDate</b>: 1990-01-01</p><p><b>address</b>: 987 Main St Anytown 12345 US </p></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/us/core/StructureDefinition/us-core-birthsex">
          <valueCode value="M"/>
        </extension>
        <identifier>
          <use value="usual"/>
          <type>
            <coding>
              <system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
              <code value="PT"/>
              <display value="Patient external identifier"/>
            </coding>
          </type>
          <system value="https://www.gensop.com"/>
          <value value="22ea1d1b-03a5-47d6-81e0-b9b4cbb15ccf"/>
        </identifier>
        <identifier>
          <type>
            <coding>
              <system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
              <code value="MR"/>
              <display value="Medical Record Number"/>
            </coding>
          </type>
          <system value="http://hospital.example.org"/>
          <value value="123456789"/>
        </identifier>
        <name>
          <family value="Anyperson"/>
          <given value="Adam"/>
        </name>
        <gender value="male"/>
        <birthDate value="1990-01-01"/>
        <address>
          <line value="987 Main St"/>
          <city value="Anytown"/>
          <postalCode value="12345"/>
          <country value="US"/>
        </address>
      </Patient>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/DiagnosticReport/gx-genomics-report-adam-anyperson"/>
    <resource>
      <DiagnosticReport>
        <id value="gx-genomics-report-adam-anyperson"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomics-report"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: DiagnosticReport</b><a name="gx-genomics-report-adam-anyperson"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource DiagnosticReport &quot;gx-genomics-report-adam-anyperson&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-mcode-genomics-report.html">Genomics Report Profile</a></p></div><p><b>basedOn</b>: <a href="#ServiceRequest_gx-order-tumornormal-gensop-inc">See above (ServiceRequest/gx-order-tumornormal-gensop-inc)</a></p><p><b>status</b>: final</p><p><b>category</b>: Genetics <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v2-0074.html">diagnosticServiceSectionId</a>#GE)</span></p><p><b>code</b>: Genetic analysis report <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#51969-4)</span></p><p><b>subject</b>: <a href="#Patient_gx-cancer-patient-adam-anyperson">See above (Patient/gx-cancer-patient-adam-anyperson)</a></p><p><b>effective</b>: 2022-02-15 19:28:58+0500</p><p><b>performer</b>: <a href="Organization-gx-us-core-organization-gensop-inc.html">Organization/gx-us-core-organization-gensop-inc</a> &quot;Gensop Labs, Inc.&quot;</p><p><b>resultsInterpreter</b>: <a href="#Practitioner_gx-practitioner-test-pathologist">See above (Practitioner/gx-practitioner-test-pathologist)</a></p><p><b>specimen</b>: </p><ul><li><a href="#Specimen_gx-genomic-specimen-tumornormal-tumor">See above (Specimen/gx-genomic-specimen-tumornormal-tumor)</a></li><li><a href="#Specimen_gx-genomic-specimen-tumornormal-normal">See above (Specimen/gx-genomic-specimen-tumornormal-normal)</a></li></ul><p><b>result</b>: </p><ul><li><a href="#Observation_gx-genomic-variant-somatic-bap1-indel">See above (Observation/gx-genomic-variant-somatic-bap1-indel)</a></li><li><a href="#Observation_gx-genomic-variant-somatic-cdkn2a-cnv">See above (Observation/gx-genomic-variant-somatic-cdkn2a-cnv)</a></li><li><a href="#Observation_gx-genomic-variant-somatic-cdkn2b-cnv">See above (Observation/gx-genomic-variant-somatic-cdkn2b-cnv)</a></li><li><a href="#Observation_gx-genomic-variant-somatic-kdm5d">See above (Observation/gx-genomic-variant-somatic-kdm5d)</a></li><li><a href="#Observation_gx-genomic-variant-somatic-mtap">See above (Observation/gx-genomic-variant-somatic-mtap)</a></li><li><a href="#Observation_gx-genomic-variant-somatic-mycn">See above (Observation/gx-genomic-variant-somatic-mycn)</a></li><li><a href="#Observation_gx-genomic-variant-somatic-pof1b">See above (Observation/gx-genomic-variant-somatic-pof1b)</a></li><li><a href="#Observation_gx-genomic-variant-somatic-polrmt">See above (Observation/gx-genomic-variant-somatic-polrmt)</a></li><li><a href="#Observation_gx-genomic-diagnostic-implication-bap1">See above (Observation/gx-genomic-diagnostic-implication-bap1)</a></li><li><a href="#Observation_gx-genomic-diagnostic-implication-pof1b">See above (Observation/gx-genomic-diagnostic-implication-pof1b)</a></li><li><a href="#Observation_gx-genomic-diagnostic-implication-polrmt">See above (Observation/gx-genomic-diagnostic-implication-polrmt)</a></li><li><a href="#Observation_gx-genomic-variant-fusion-met-alk">See above (Observation/gx-genomic-variant-fusion-met-alk)</a></li><li><a href="#Observation_gx-genomic-variant-pertinent-negative-nras-kit-braf">See above (Observation/gx-genomic-variant-pertinent-negative-nras-kit-braf)</a></li><li><a href="#Observation_gx-genomic-tmb">See above (Observation/gx-genomic-tmb)</a></li><li><a href="Observation-gx-genomic-msi.html">Observation/gx-genomic-msi</a></li><li><a href="#Observation_gx-genomic-therapeutic-implication-alectinib">See above (Observation/gx-genomic-therapeutic-implication-alectinib)</a></li><li><a href="#Observation_gx-genomic-therapeutic-implication-brigatinib">See above (Observation/gx-genomic-therapeutic-implication-brigatinib)</a></li><li><a href="#Observation_gx-genomic-therapeutic-implication-ceritinib">See above (Observation/gx-genomic-therapeutic-implication-ceritinib)</a></li><li><a href="#Observation_gx-genomic-therapeutic-implication-crizotinib">See above (Observation/gx-genomic-therapeutic-implication-crizotinib)</a></li><li><a href="#Observation_gx-genomic-therapeutic-implication-lorlatinib">See above (Observation/gx-genomic-therapeutic-implication-lorlatinib)</a></li></ul></div>
        </text>
        <basedOn>
          <reference value="ServiceRequest/gx-order-tumornormal-gensop-inc"/>
        </basedOn>
        <status value="final"/>
        <category>
          <coding>
            <system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
            <code value="GE"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="51969-4"/>
            <display value="Genetic analysis report"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2022-02-15T19:28:58+05:00"/>
        <performer>
          <reference value="Organization/gx-us-core-organization-gensop-inc"/>
        </performer>
        <resultsInterpreter>
          <reference value="Practitioner/gx-practitioner-test-pathologist"/>
        </resultsInterpreter>
        <specimen>
          <reference value="Specimen/gx-genomic-specimen-tumornormal-tumor"/>
        </specimen>
        <specimen>
          <reference value="Specimen/gx-genomic-specimen-tumornormal-normal"/>
        </specimen>
        <result>
          <reference
                     value="Observation/gx-genomic-variant-somatic-bap1-indel"/>
        </result>
        <result>
          <reference
                     value="Observation/gx-genomic-variant-somatic-cdkn2a-cnv"/>
        </result>
        <result>
          <reference
                     value="Observation/gx-genomic-variant-somatic-cdkn2b-cnv"/>
        </result>
        <result>
          <reference value="Observation/gx-genomic-variant-somatic-kdm5d"/>
        </result>
        <result>
          <reference value="Observation/gx-genomic-variant-somatic-mtap"/>
        </result>
        <result>
          <reference value="Observation/gx-genomic-variant-somatic-mycn"/>
        </result>
        <result>
          <reference value="Observation/gx-genomic-variant-somatic-pof1b"/>
        </result>
        <result>
          <reference value="Observation/gx-genomic-variant-somatic-polrmt"/>
        </result>
        <result>
          <reference
                     value="Observation/gx-genomic-diagnostic-implication-bap1"/>
        </result>
        <result>
          <reference
                     value="Observation/gx-genomic-diagnostic-implication-pof1b"/>
        </result>
        <result>
          <reference
                     value="Observation/gx-genomic-diagnostic-implication-polrmt"/>
        </result>
        <result>
          <reference value="Observation/gx-genomic-variant-fusion-met-alk"/>
        </result>
        <result>
          <reference
                     value="Observation/gx-genomic-variant-pertinent-negative-nras-kit-braf"/>
        </result>
        <result>
          <reference value="Observation/gx-genomic-tmb"/>
        </result>
        <result>
          <reference value="Observation/gx-genomic-msi"/>
        </result>
        <result>
          <reference
                     value="Observation/gx-genomic-therapeutic-implication-alectinib"/>
        </result>
        <result>
          <reference
                     value="Observation/gx-genomic-therapeutic-implication-brigatinib"/>
        </result>
        <result>
          <reference
                     value="Observation/gx-genomic-therapeutic-implication-ceritinib"/>
        </result>
        <result>
          <reference
                     value="Observation/gx-genomic-therapeutic-implication-crizotinib"/>
        </result>
        <result>
          <reference
                     value="Observation/gx-genomic-therapeutic-implication-lorlatinib"/>
        </result>
      </DiagnosticReport>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/ServiceRequest/gx-order-tumornormal-gensop-inc"/>
    <resource>
      <ServiceRequest>
        <id value="gx-order-tumornormal-gensop-inc"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: ServiceRequest</b><a name="gx-order-tumornormal-gensop-inc"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ServiceRequest &quot;gx-order-tumornormal-gensop-inc&quot; </p></div><p><b>identifier</b>: Filler Identifier: 22howe</p><p><b>status</b>: completed</p><p><b>intent</b>: order</p><p><b>code</b>: xT - 648 gene panel <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (www.gensop.com#XT.V4)</span></p><p><b>subject</b>: <a href="#Patient_gx-cancer-patient-adam-anyperson">See above (Patient/gx-cancer-patient-adam-anyperson)</a></p><p><b>reasonCode</b>: Malignant neoplasm of unspecified part of bronchus or lung <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-icd10CM.html">International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM)</a>#C34.9; <a href="http://terminology.hl7.org/5.3.0/CodeSystem-icd-o-3.html">International Classification of Diseases for Oncology, version 3.</a>#C34.9 8140/3 &quot;Lung adenocarcinoma&quot;)</span></p></div>
        </text>
        <identifier>
          <type>
            <coding>
              <system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
              <code value="FILL"/>
              <display value="Filler Identifier"/>
            </coding>
          </type>
          <system value="https://www.gensop.com"/>
          <value value="22howe"/>
        </identifier>
        <status value="completed"/>
        <intent value="order"/>
        <code>
          <coding>
            <system value="https://www.gensop.com"/>
            <code value="XT.V4"/>
            <display value="xT - 648 gene panel"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <reasonCode>
          <coding>
            <system value="http://hl7.org/fhir/sid/icd-10-cm"/>
            <code value="C34.9"/>
            <display
                     value="Malignant neoplasm of unspecified part of bronchus or lung"/>
          </coding>
          <coding>
            <system value="http://terminology.hl7.org/CodeSystem/icd-o-3"/>
            <code value="C34.9 8140/3"/>
            <display value="Lung adenocarcinoma"/>
          </coding>
        </reasonCode>
      </ServiceRequest>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Practitioner/gx-practitioner-test-pathologist"/>
    <resource>
      <Practitioner>
        <id value="gx-practitioner-test-pathologist"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Practitioner</b><a name="gx-practitioner-test-pathologist"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Practitioner &quot;gx-practitioner-test-pathologist&quot; </p></div><p><b>name</b>: Test Pathologist, MD</p></div>
        </text>
        <name>
          <text value="Test Pathologist, MD"/>
        </name>
      </Practitioner>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Specimen/gx-genomic-specimen-tumornormal-tumor"/>
    <resource>
      <Specimen>
        <id value="gx-genomic-specimen-tumornormal-tumor"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-human-specimen"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Specimen</b><a name="gx-genomic-specimen-tumornormal-tumor"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Specimen &quot;gx-genomic-specimen-tumornormal-tumor&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-mcode-human-specimen.html">Human Specimen Profile</a></p></div><p><b>status</b>: available</p><p><b>type</b>: Tumor <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v2-0487.html">specimenType</a>#TUMOR)</span></p><p><b>subject</b>: <a href="#Patient_gx-cancer-patient-adam-anyperson">See above (Patient/gx-cancer-patient-adam-anyperson)</a></p><p><b>receivedTime</b>: 2021-02-09 21:30:50+0500</p><h3>Collections</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Collected[x]</b></td><td><b>BodySite</b></td></tr><tr><td style="display: none">*</td><td>2021-02-06 17:15:00+0500</td><td>Left lung structure (body structure) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://browser.ihtsdotools.org/">SNOMED CT</a>#44029006)</span></td></tr></table></div>
        </text>
        <status value="available"/>
        <type>
          <coding>
            <system value="http://terminology.hl7.org/CodeSystem/v2-0487"/>
            <code value="TUMOR"/>
            <display value="Tumor"/>
          </coding>
        </type>
        <subject>
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <receivedTime value="2021-02-09T21:30:50+05:00"/>
        <collection>
          <collectedDateTime value="2021-02-06T17:15:00+05:00"/>
          <bodySite>
            <coding>
              <system value="http://snomed.info/sct"/>
              <code value="44029006"/>
              <display value="Left lung structure (body structure)"/>
            </coding>
          </bodySite>
        </collection>
      </Specimen>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Specimen/gx-genomic-specimen-tumornormal-normal"/>
    <resource>
      <Specimen>
        <id value="gx-genomic-specimen-tumornormal-normal"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-human-specimen"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Specimen</b><a name="gx-genomic-specimen-tumornormal-normal"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Specimen &quot;gx-genomic-specimen-tumornormal-normal&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-mcode-human-specimen.html">Human Specimen Profile</a></p></div><p><b>status</b>: available</p><p><b>type</b>: Whole Blood <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v2-0487.html">specimenType</a>#BLD)</span></p><p><b>subject</b>: <a href="#Patient_gx-cancer-patient-adam-anyperson">See above (Patient/gx-cancer-patient-adam-anyperson)</a></p><p><b>receivedTime</b>: 2021-02-09 21:30:50+0500</p><h3>Collections</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Collected[x]</b></td></tr><tr><td style="display: none">*</td><td>2021-02-06 17:15:00+0500</td></tr></table></div>
        </text>
        <status value="available"/>
        <type>
          <coding>
            <system value="http://terminology.hl7.org/CodeSystem/v2-0487"/>
            <code value="BLD"/>
            <display value="Whole Blood"/>
          </coding>
        </type>
        <subject>
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <receivedTime value="2021-02-09T21:30:50+05:00"/>
        <collection>
          <collectedDateTime value="2021-02-06T17:15:00+05:00"/>
        </collection>
      </Specimen>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-variant-somatic-bap1-indel"/>
    <resource>
      <Observation>
        <id value="gx-genomic-variant-somatic-bap1-indel"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="gx-genomic-variant-somatic-bap1-indel"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;gx-genomic-variant-somatic-bap1-indel&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-mcode-genomic-variant.html">Genomic Variant Profile</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: 69548-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#69548-6)</span></p><p><b>subject</b>: <a href="#Patient_gx-cancer-patient-adam-anyperson">See above (Patient/gx-cancer-patient-adam-anyperson)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner/us-core-practitioner-owen-oncologist</a> &quot; ONCOLOGIST&quot;</p><p><b>value</b>: Present <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA9633-4)</span></p><p><b>method</b>: Sequencing <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA26398-0)</span></p><blockquote><p><b>component</b></p><p><b>code</b>: 48018-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48018-6)</span></p><p><b>value</b>: BAP1 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html">HUGO Gene Nomenclature Committee Genes</a>#HGNC:950; gene#3815)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 51958-7 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#51958-7)</span></p><p><b>value</b>: NM_004656.4 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-refSeq.html">Gene Reference Sequence Collection</a>#NM_004656)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 48004-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48004-6)</span></p><p><b>value</b>: NC_000003.11(NM_004656.4):c.1768C&gt;T <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgvs.html">Human Genome Variation Society nomenclature</a>#NM_004656.4:c.1768C&gt;T)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 48005-3 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48005-3)</span></p><p><b>value</b>: NP_004647.1:p.(Gln590Ter) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgvs.html">Human Genome Variation Society nomenclature</a>#NP_004647.1:p.(Gln590Ter))</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 48002-0 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48002-0)</span></p><p><b>value</b>: Somatic <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA6684-0)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 81258-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#81258-6)</span></p><p><b>value</b>: 57.4 %<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Molecular Consequence <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html">To Be Determined Codes</a>#molecular-consequence)</span></p><p><b>value</b>: stop_gained <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (#SO:0001587)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 62374-4 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#62374-4)</span></p><p><b>value</b>: GRCh37 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA14029-5)</span></p></blockquote></div>
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  <entry>
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        <meta>
          <profile
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        <text>
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          <div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="gx-genomic-variant-somatic-cdkn2a-cnv"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;gx-genomic-variant-somatic-cdkn2a-cnv&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-mcode-genomic-variant.html">Genomic Variant Profile</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: 69548-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#69548-6)</span></p><p><b>subject</b>: <a href="#Patient_gx-cancer-patient-adam-anyperson">See above (Patient/gx-cancer-patient-adam-anyperson)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner/us-core-practitioner-owen-oncologist</a> &quot; ONCOLOGIST&quot;</p><p><b>value</b>: Present <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA9633-4)</span></p><p><b>method</b>: Sequencing <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA26398-0)</span></p><blockquote><p><b>component</b></p><p><b>code</b>: 48018-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48018-6)</span></p><p><b>value</b>: CDKN2A <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html">HUGO Gene Nomenclature Committee Genes</a>#HGNC:1787; gene#1029)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 48002-0 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48002-0)</span></p><p><b>value</b>: Somatic <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA6684-0)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Molecular Consequence <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html">To Be Determined Codes</a>#molecular-consequence)</span></p><p><b>value</b>: copy_number_loss <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (#SO:0001743)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 62374-4 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#62374-4)</span></p><p><b>value</b>: GRCh37 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA14029-5)</span></p></blockquote></div>
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            <code value="69548-6"/>
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  <entry>
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        <meta>
          <profile
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        <text>
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          <div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="gx-genomic-variant-somatic-cdkn2b-cnv"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;gx-genomic-variant-somatic-cdkn2b-cnv&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-mcode-genomic-variant.html">Genomic Variant Profile</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: 69548-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#69548-6)</span></p><p><b>subject</b>: <a href="#Patient_gx-cancer-patient-adam-anyperson">See above (Patient/gx-cancer-patient-adam-anyperson)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner/us-core-practitioner-owen-oncologist</a> &quot; ONCOLOGIST&quot;</p><p><b>value</b>: Present <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA9633-4)</span></p><p><b>method</b>: Sequencing <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA26398-0)</span></p><blockquote><p><b>component</b></p><p><b>code</b>: 48018-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48018-6)</span></p><p><b>value</b>: CDKN2B <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html">HUGO Gene Nomenclature Committee Genes</a>#HGNC:1788; gene#1030)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 48002-0 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48002-0)</span></p><p><b>value</b>: Somatic <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA6684-0)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Molecular Consequence <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html">To Be Determined Codes</a>#molecular-consequence)</span></p><p><b>value</b>: copy_number_loss <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (#SO:0001743)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 62374-4 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#62374-4)</span></p><p><b>value</b>: GRCh37 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA14029-5)</span></p></blockquote></div>
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              <system value="http://loinc.org"/>
              <code value="LA14029-5"/>
              <display value="GRCh37"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-variant-somatic-kdm5d"/>
    <resource>
      <Observation>
        <id value="gx-genomic-variant-somatic-kdm5d"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="gx-genomic-variant-somatic-kdm5d"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;gx-genomic-variant-somatic-kdm5d&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-mcode-genomic-variant.html">Genomic Variant Profile</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: 69548-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#69548-6)</span></p><p><b>subject</b>: <a href="#Patient_gx-cancer-patient-adam-anyperson">See above (Patient/gx-cancer-patient-adam-anyperson)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner/us-core-practitioner-owen-oncologist</a> &quot; ONCOLOGIST&quot;</p><p><b>value</b>: Present <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA9633-4)</span></p><p><b>method</b>: Sequencing <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA26398-0)</span></p><blockquote><p><b>component</b></p><p><b>code</b>: 48018-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48018-6)</span></p><p><b>value</b>: KDM5D <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html">HUGO Gene Nomenclature Committee Genes</a>#HGNC:11115; gene#8284)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 48002-0 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48002-0)</span></p><p><b>value</b>: Somatic <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA6684-0)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Molecular Consequence <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html">To Be Determined Codes</a>#molecular-consequence)</span></p><p><b>value</b>: copy_number_loss <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (#SO:0001743)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 62374-4 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#62374-4)</span></p><p><b>value</b>: GRCh37 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA14029-5)</span></p></blockquote></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="69548-6"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA9633-4"/>
            <display value="Present"/>
          </coding>
        </valueCodeableConcept>
        <method>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA26398-0"/>
            <display value="Sequencing"/>
          </coding>
        </method>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48018-6"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.genenames.org"/>
              <code value="HGNC:11115"/>
              <display value="KDM5D"/>
            </coding>
            <coding>
              <system value="https://www.ncbi.nlm.nih.gov/gene"/>
              <code value="8284"/>
              <display value="KDM5D"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48002-0"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA6684-0"/>
              <display value="Somatic"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system
                      value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
              <code value="molecular-consequence"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.sequenceontology.org/"/>
              <code value="SO:0001743"/>
              <display value="copy_number_loss"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="62374-4"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA14029-5"/>
              <display value="GRCh37"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-variant-somatic-mtap"/>
    <resource>
      <Observation>
        <id value="gx-genomic-variant-somatic-mtap"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="gx-genomic-variant-somatic-mtap"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;gx-genomic-variant-somatic-mtap&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-mcode-genomic-variant.html">Genomic Variant Profile</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: 69548-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#69548-6)</span></p><p><b>subject</b>: <a href="#Patient_gx-cancer-patient-adam-anyperson">See above (Patient/gx-cancer-patient-adam-anyperson)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner/us-core-practitioner-owen-oncologist</a> &quot; ONCOLOGIST&quot;</p><p><b>value</b>: Present <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA9633-4)</span></p><p><b>method</b>: Sequencing <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA26398-0)</span></p><blockquote><p><b>component</b></p><p><b>code</b>: 48018-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48018-6)</span></p><p><b>value</b>: MTAP <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html">HUGO Gene Nomenclature Committee Genes</a>#HGNC:7413; gene#4507)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 48002-0 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48002-0)</span></p><p><b>value</b>: Somatic <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA6684-0)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Molecular Consequence <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html">To Be Determined Codes</a>#molecular-consequence)</span></p><p><b>value</b>: copy_number_loss <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (#SO:0001743)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 62374-4 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#62374-4)</span></p><p><b>value</b>: GRCh37 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA14029-5)</span></p></blockquote></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="69548-6"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA9633-4"/>
            <display value="Present"/>
          </coding>
        </valueCodeableConcept>
        <method>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA26398-0"/>
            <display value="Sequencing"/>
          </coding>
        </method>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48018-6"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.genenames.org"/>
              <code value="HGNC:7413"/>
              <display value="MTAP"/>
            </coding>
            <coding>
              <system value="https://www.ncbi.nlm.nih.gov/gene"/>
              <code value="4507"/>
              <display value="MTAP"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48002-0"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA6684-0"/>
              <display value="Somatic"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system
                      value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
              <code value="molecular-consequence"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.sequenceontology.org/"/>
              <code value="SO:0001743"/>
              <display value="copy_number_loss"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="62374-4"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA14029-5"/>
              <display value="GRCh37"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-variant-somatic-mycn"/>
    <resource>
      <Observation>
        <id value="gx-genomic-variant-somatic-mycn"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="gx-genomic-variant-somatic-mycn"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;gx-genomic-variant-somatic-mycn&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-mcode-genomic-variant.html">Genomic Variant Profile</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: 69548-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#69548-6)</span></p><p><b>subject</b>: <a href="#Patient_gx-cancer-patient-adam-anyperson">See above (Patient/gx-cancer-patient-adam-anyperson)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner/us-core-practitioner-owen-oncologist</a> &quot; ONCOLOGIST&quot;</p><p><b>value</b>: Present <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA9633-4)</span></p><p><b>method</b>: Sequencing <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA26398-0)</span></p><blockquote><p><b>component</b></p><p><b>code</b>: 48018-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48018-6)</span></p><p><b>value</b>: MYCN <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html">HUGO Gene Nomenclature Committee Genes</a>#HGNC:7559; gene#4613)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 48002-0 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48002-0)</span></p><p><b>value</b>: Somatic <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA6684-0)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Molecular Consequence <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html">To Be Determined Codes</a>#molecular-consequence)</span></p><p><b>value</b>: copy_number_gain <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (#SO:0001742)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 62374-4 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#62374-4)</span></p><p><b>value</b>: GRCh37 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA14029-5)</span></p></blockquote></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="69548-6"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA9633-4"/>
            <display value="Present"/>
          </coding>
        </valueCodeableConcept>
        <method>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA26398-0"/>
            <display value="Sequencing"/>
          </coding>
        </method>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48018-6"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.genenames.org"/>
              <code value="HGNC:7559"/>
              <display value="MYCN"/>
            </coding>
            <coding>
              <system value="https://www.ncbi.nlm.nih.gov/gene"/>
              <code value="4613"/>
              <display value="MYCN"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48002-0"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA6684-0"/>
              <display value="Somatic"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system
                      value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
              <code value="molecular-consequence"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.sequenceontology.org/"/>
              <code value="SO:0001742"/>
              <display value="copy_number_gain"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="62374-4"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA14029-5"/>
              <display value="GRCh37"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-variant-somatic-pof1b"/>
    <resource>
      <Observation>
        <id value="gx-genomic-variant-somatic-pof1b"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="gx-genomic-variant-somatic-pof1b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;gx-genomic-variant-somatic-pof1b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-mcode-genomic-variant.html">Genomic Variant Profile</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: 69548-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#69548-6)</span></p><p><b>subject</b>: <a href="#Patient_gx-cancer-patient-adam-anyperson">See above (Patient/gx-cancer-patient-adam-anyperson)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner/us-core-practitioner-owen-oncologist</a> &quot; ONCOLOGIST&quot;</p><p><b>value</b>: Present <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA9633-4)</span></p><p><b>method</b>: Sequencing <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA26398-0)</span></p><blockquote><p><b>component</b></p><p><b>code</b>: 48018-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48018-6)</span></p><p><b>value</b>: POF1B <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html">HUGO Gene Nomenclature Committee Genes</a>#HGNC:13711; gene#79983)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 48002-0 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48002-0)</span></p><p><b>value</b>: Somatic <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA6684-0)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Molecular Consequence <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html">To Be Determined Codes</a>#molecular-consequence)</span></p><p><b>value</b>: missense_variant <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (#SO:0001583)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 51958-7 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#51958-7)</span></p><p><b>value</b>: NM_004656 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-refSeq.html">Gene Reference Sequence Collection</a>#NM_004656)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 48004-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48004-6)</span></p><p><b>value</b>: NM_001307940.2:c.430C&gt;T <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgvs.html">Human Genome Variation Society nomenclature</a>#NM_001307940.2:c.430C&gt;T)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 48005-3 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48005-3)</span></p><p><b>value</b>: NP_001294869.1:p.(Pro144Ser) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgvs.html">Human Genome Variation Society nomenclature</a>#NP_001294869.1:p.(Pro144Ser))</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 81258-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#81258-6)</span></p><p><b>value</b>: 78.6 %<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 62374-4 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#62374-4)</span></p><p><b>value</b>: GRCh37 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA14029-5)</span></p></blockquote></div>
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  <entry>
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        <meta>
          <profile
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        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="gx-genomic-variant-somatic-polrmt"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;gx-genomic-variant-somatic-polrmt&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-mcode-genomic-variant.html">Genomic Variant Profile</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: 69548-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#69548-6)</span></p><p><b>subject</b>: <a href="#Patient_gx-cancer-patient-adam-anyperson">See above (Patient/gx-cancer-patient-adam-anyperson)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner/us-core-practitioner-owen-oncologist</a> &quot; ONCOLOGIST&quot;</p><p><b>value</b>: Present <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA9633-4)</span></p><p><b>method</b>: Sequencing <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA26398-0)</span></p><blockquote><p><b>component</b></p><p><b>code</b>: 48018-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48018-6)</span></p><p><b>value</b>: POLRMT <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (gene#5442)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 48002-0 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48002-0)</span></p><p><b>value</b>: Somatic <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA6684-0)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Molecular Consequence <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html">To Be Determined Codes</a>#molecular-consequence)</span></p><p><b>value</b>: missense_variant <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (#SO:0001583)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 51958-7 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#51958-7)</span></p><p><b>value</b>: NM_005035 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-refSeq.html">Gene Reference Sequence Collection</a>#NM_004656)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 48004-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48004-6)</span></p><p><b>value</b>: NM_005035.4:c.598G&gt;A <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgvs.html">Human Genome Variation Society nomenclature</a>#NM_005035.4:c.598G&gt;A)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 48005-3 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48005-3)</span></p><p><b>value</b>: NP_005026.3:p.(Gly200Arg) <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgvs.html">Human Genome Variation Society nomenclature</a>#NP_005026.3:p.(Gly200Arg))</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 81258-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#81258-6)</span></p><p><b>value</b>: 75.6 %<span style="background: LightGoldenRodYellow"> (Details: UCUM code % = '%')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 62374-4 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#62374-4)</span></p><p><b>value</b>: GRCh37 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA14029-5)</span></p></blockquote></div>
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        <effectiveDateTime value="2019-04-01"/>
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        <meta>
          <profile
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        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="gx-genomic-diagnostic-implication-bap1"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;gx-genomic-diagnostic-implication-bap1&quot; </p><p style="margin-bottom: 0px">Profile: <a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/StructureDefinition-diagnostic-implication.html">Diagnostic Implication</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Diagnostic Implication <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html">To Be Determined Codes</a>#diagnostic-implication)</span></p><p><b>subject</b>: <a href="#Patient_gx-cancer-patient-adam-anyperson">See above (Patient/gx-cancer-patient-adam-anyperson)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner/us-core-practitioner-owen-oncologist</a> &quot; ONCOLOGIST&quot;</p><p><b>derivedFrom</b>: <a href="#Observation_gx-genomic-variant-somatic-bap1-indel">See above (Observation/gx-genomic-variant-somatic-bap1-indel)</a></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>Functional Effect <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html">To Be Determined Codes</a>#functional-effect)</span></td><td>loss of function variant <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (#SO:0002054)</span></td></tr></table></div>
        </text>
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          <coding>
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            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system
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            <code value="diagnostic-implication"/>
          </coding>
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        <subject>
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>
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        <derivedFrom>
          <reference
                     value="Observation/gx-genomic-variant-somatic-bap1-indel"/>
        </derivedFrom>
        <component>
          <code>
            <coding>
              <system
                      value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
              <code value="functional-effect"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.sequenceontology.org/"/>
              <code value="SO:0002054"/>
              <display value="loss of function variant"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-diagnostic-implication-pof1b"/>
    <resource>
      <Observation>
        <id value="gx-genomic-diagnostic-implication-pof1b"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="gx-genomic-diagnostic-implication-pof1b"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;gx-genomic-diagnostic-implication-pof1b&quot; </p><p style="margin-bottom: 0px">Profile: <a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/StructureDefinition-diagnostic-implication.html">Diagnostic Implication</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Diagnostic Implication <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html">To Be Determined Codes</a>#diagnostic-implication)</span></p><p><b>subject</b>: <a href="#Patient_gx-cancer-patient-adam-anyperson">See above (Patient/gx-cancer-patient-adam-anyperson)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner/us-core-practitioner-owen-oncologist</a> &quot; ONCOLOGIST&quot;</p><p><b>derivedFrom</b>: <a href="#Observation_gx-genomic-variant-somatic-pof1b">See above (Observation/gx-genomic-variant-somatic-pof1b)</a></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>53037-8 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#53037-8)</span></td><td>Uncertain significance <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA26333-7)</span></td></tr></table></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
            <code value="diagnostic-implication"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <derivedFrom>
          <reference value="Observation/gx-genomic-variant-somatic-pof1b"/>
        </derivedFrom>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="53037-8"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA26333-7"/>
              <display value="Uncertain significance"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-diagnostic-implication-polrmt"/>
    <resource>
      <Observation>
        <id value="gx-genomic-diagnostic-implication-polrmt"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="gx-genomic-diagnostic-implication-polrmt"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;gx-genomic-diagnostic-implication-polrmt&quot; </p><p style="margin-bottom: 0px">Profile: <a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/StructureDefinition-diagnostic-implication.html">Diagnostic Implication</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Diagnostic Implication <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html">To Be Determined Codes</a>#diagnostic-implication)</span></p><p><b>subject</b>: <a href="#Patient_gx-cancer-patient-adam-anyperson">See above (Patient/gx-cancer-patient-adam-anyperson)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner/us-core-practitioner-owen-oncologist</a> &quot; ONCOLOGIST&quot;</p><p><b>derivedFrom</b>: <a href="#Observation_gx-genomic-variant-somatic-polrmt">See above (Observation/gx-genomic-variant-somatic-polrmt)</a></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td>53037-8 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#53037-8)</span></td><td>Uncertain significance <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA26333-7)</span></td></tr></table></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
            <code value="diagnostic-implication"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <derivedFrom>
          <reference value="Observation/gx-genomic-variant-somatic-polrmt"/>
        </derivedFrom>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="53037-8"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA26333-7"/>
              <display value="Uncertain significance"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-variant-fusion-met-alk"/>
    <resource>
      <Observation>
        <id value="gx-genomic-variant-fusion-met-alk"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="gx-genomic-variant-fusion-met-alk"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;gx-genomic-variant-fusion-met-alk&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-mcode-genomic-variant.html">Genomic Variant Profile</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: 69548-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#69548-6)</span></p><p><b>subject</b>: <a href="#Patient_gx-cancer-patient-adam-anyperson">See above (Patient/gx-cancer-patient-adam-anyperson)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner/us-core-practitioner-owen-oncologist</a> &quot; ONCOLOGIST&quot;</p><p><b>value</b>: Present <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA9633-4)</span></p><p><b>method</b>: Sequencing <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA26398-0)</span></p><blockquote><p><b>component</b></p><p><b>code</b>: 48018-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48018-6)</span></p><p><b>value</b>: MET <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html">HUGO Gene Nomenclature Committee Genes</a>#HGNC:7029; gene#4233)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 48018-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48018-6)</span></p><p><b>value</b>: ALK <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html">HUGO Gene Nomenclature Committee Genes</a>#HGNC:427; gene#238)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 48019-4 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48019-4)</span></p><p><b>value</b>: complex chromosomal rearrangement <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (#SO:0002062)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 48002-0 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48002-0)</span></p><p><b>value</b>: Somatic <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA6684-0)</span></p></blockquote></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="69548-6"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA9633-4"/>
            <display value="Present"/>
          </coding>
        </valueCodeableConcept>
        <method>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA26398-0"/>
            <display value="Sequencing"/>
          </coding>
        </method>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48018-6"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.genenames.org"/>
              <code value="HGNC:7029"/>
              <display value="MET"/>
            </coding>
            <coding>
              <system value="https://www.ncbi.nlm.nih.gov/gene"/>
              <code value="4233"/>
              <display value="MET"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48018-6"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.genenames.org"/>
              <code value="HGNC:427"/>
              <display value="ALK"/>
            </coding>
            <coding>
              <system value="https://www.ncbi.nlm.nih.gov/gene"/>
              <code value="238"/>
              <display value="ALK"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48019-4"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.sequenceontology.org/"/>
              <code value="SO:0002062"/>
              <display value="complex chromosomal rearrangement"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48002-0"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA6684-0"/>
              <display value="Somatic"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-variant-pertinent-negative-nras-kit-braf"/>
    <resource>
      <Observation>
        <id value="gx-genomic-variant-pertinent-negative-nras-kit-braf"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="gx-genomic-variant-pertinent-negative-nras-kit-braf"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;gx-genomic-variant-pertinent-negative-nras-kit-braf&quot; </p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-mcode-genomic-variant.html">Genomic Variant Profile</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: 69548-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#69548-6)</span></p><p><b>subject</b>: <a href="#Patient_gx-cancer-patient-adam-anyperson">See above (Patient/gx-cancer-patient-adam-anyperson)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner/us-core-practitioner-owen-oncologist</a> &quot; ONCOLOGIST&quot;</p><p><b>value</b>: Absent <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA9634-2)</span></p><p><b>method</b>: Sequencing <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA26398-0)</span></p><blockquote><p><b>component</b></p><p><b>code</b>: 48018-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48018-6)</span></p><p><b>value</b>: NRAS <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html">HUGO Gene Nomenclature Committee Genes</a>#HGNC:6342)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 48018-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48018-6)</span></p><p><b>value</b>: KIT <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html">HUGO Gene Nomenclature Committee Genes</a>#HGNC:7989)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: 48018-6 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#48018-6)</span></p><p><b>value</b>: BRAF <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-hgnc.html">HUGO Gene Nomenclature Committee Genes</a>#HGNC:1097)</span></p></blockquote></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="69548-6"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA9634-2"/>
            <display value="Absent"/>
          </coding>
        </valueCodeableConcept>
        <method>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA26398-0"/>
            <display value="Sequencing"/>
          </coding>
        </method>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48018-6"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.genenames.org"/>
              <code value="HGNC:6342"/>
              <display value="NRAS"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48018-6"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.genenames.org"/>
              <code value="HGNC:7989"/>
              <display value="KIT"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48018-6"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.genenames.org"/>
              <code value="HGNC:1097"/>
              <display value="BRAF"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl value="http://example.org/fhir/Observation/gx-genomic-tmb"/>
    <resource>
      <Observation>
        <id value="gx-genomic-tmb"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/tmb"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="gx-genomic-tmb"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;gx-genomic-tmb&quot; </p><p style="margin-bottom: 0px">Profile: <a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/StructureDefinition-tmb.html">Tumor Mutation Burden</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: 94076-7 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#94076-7)</span></p><p><b>subject</b>: <a href="#Patient_gx-cancer-patient-adam-anyperson">See above (Patient/gx-cancer-patient-adam-anyperson)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner/us-core-practitioner-owen-oncologist</a> &quot; ONCOLOGIST&quot;</p><p><b>value</b>: 57.1 1/1000000{Base}<span style="background: LightGoldenRodYellow"> (Details: UCUM code 1/1000000{Base} = '1/1000000{Base}')</span></p></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="94076-7"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <valueQuantity>
          <value value="57.1"/>
          <system value="http://unitsofmeasure.org"/>
          <code value="1/1000000{Base}"/>
        </valueQuantity>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-alectinib"/>
    <resource>
      <Observation>
        <id value="gx-genomic-therapeutic-implication-alectinib"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="gx-genomic-therapeutic-implication-alectinib"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;gx-genomic-therapeutic-implication-alectinib&quot; </p><p style="margin-bottom: 0px">Profile: <a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/StructureDefinition-therapeutic-implication.html">Therapeutic Implication</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Therapeutic Implication <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html">To Be Determined Codes</a>#therapeutic-implication)</span></p><p><b>subject</b>: <a href="#Patient_gx-cancer-patient-adam-anyperson">See above (Patient/gx-cancer-patient-adam-anyperson)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner/us-core-practitioner-owen-oncologist</a> &quot; ONCOLOGIST&quot;</p><p><b>derivedFrom</b>: <a href="#Observation_gx-genomic-variant-fusion-met-alk">See above (Observation/gx-genomic-variant-fusion-met-alk)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: 51963-7 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#51963-7)</span></p><p><b>value</b>: alectinib <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-rxNorm.html">RxNorm</a>#1727455)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Predicted Therapeutic Implication <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html">To Be Determined Codes</a>#predicted-therapeutic-implication)</span></p><p><b>value</b>: Presumed responsive <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA9661-5)</span></p></blockquote></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
            <code value="therapeutic-implication"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <derivedFrom>
          <reference value="Observation/gx-genomic-variant-fusion-met-alk"/>
        </derivedFrom>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="51963-7"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.nlm.nih.gov/research/umls/rxnorm"/>
              <code value="1727455"/>
              <display value="alectinib"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system
                      value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
              <code value="predicted-therapeutic-implication"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA9661-5"/>
              <display value="Presumed responsive"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-brigatinib"/>
    <resource>
      <Observation>
        <id value="gx-genomic-therapeutic-implication-brigatinib"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="gx-genomic-therapeutic-implication-brigatinib"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;gx-genomic-therapeutic-implication-brigatinib&quot; </p><p style="margin-bottom: 0px">Profile: <a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/StructureDefinition-therapeutic-implication.html">Therapeutic Implication</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Therapeutic Implication <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html">To Be Determined Codes</a>#therapeutic-implication)</span></p><p><b>subject</b>: <a href="#Patient_gx-cancer-patient-adam-anyperson">See above (Patient/gx-cancer-patient-adam-anyperson)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner/us-core-practitioner-owen-oncologist</a> &quot; ONCOLOGIST&quot;</p><p><b>derivedFrom</b>: <a href="#Observation_gx-genomic-variant-fusion-met-alk">See above (Observation/gx-genomic-variant-fusion-met-alk)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: 51963-7 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#51963-7)</span></p><p><b>value</b>: brigatinib <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-rxNorm.html">RxNorm</a>#1921217)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Predicted Therapeutic Implication <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html">To Be Determined Codes</a>#predicted-therapeutic-implication)</span></p><p><b>value</b>: Presumed responsive <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA9661-5)</span></p></blockquote></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
            <code value="therapeutic-implication"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <derivedFrom>
          <reference value="Observation/gx-genomic-variant-fusion-met-alk"/>
        </derivedFrom>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="51963-7"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.nlm.nih.gov/research/umls/rxnorm"/>
              <code value="1921217"/>
              <display value="brigatinib"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system
                      value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
              <code value="predicted-therapeutic-implication"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA9661-5"/>
              <display value="Presumed responsive"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-ceritinib"/>
    <resource>
      <Observation>
        <id value="gx-genomic-therapeutic-implication-ceritinib"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="gx-genomic-therapeutic-implication-ceritinib"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;gx-genomic-therapeutic-implication-ceritinib&quot; </p><p style="margin-bottom: 0px">Profile: <a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/StructureDefinition-therapeutic-implication.html">Therapeutic Implication</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Therapeutic Implication <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html">To Be Determined Codes</a>#therapeutic-implication)</span></p><p><b>subject</b>: <a href="#Patient_gx-cancer-patient-adam-anyperson">See above (Patient/gx-cancer-patient-adam-anyperson)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner/us-core-practitioner-owen-oncologist</a> &quot; ONCOLOGIST&quot;</p><p><b>derivedFrom</b>: <a href="#Observation_gx-genomic-variant-fusion-met-alk">See above (Observation/gx-genomic-variant-fusion-met-alk)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: 51963-7 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#51963-7)</span></p><p><b>value</b>: ceritinib <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-rxNorm.html">RxNorm</a>#1535457)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Predicted Therapeutic Implication <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html">To Be Determined Codes</a>#predicted-therapeutic-implication)</span></p><p><b>value</b>: Presumed responsive <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA9661-5)</span></p></blockquote></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
            <code value="therapeutic-implication"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <derivedFrom>
          <reference value="Observation/gx-genomic-variant-fusion-met-alk"/>
        </derivedFrom>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="51963-7"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.nlm.nih.gov/research/umls/rxnorm"/>
              <code value="1535457"/>
              <display value="ceritinib"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system
                      value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
              <code value="predicted-therapeutic-implication"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA9661-5"/>
              <display value="Presumed responsive"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-crizotinib"/>
    <resource>
      <Observation>
        <id value="gx-genomic-therapeutic-implication-crizotinib"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="gx-genomic-therapeutic-implication-crizotinib"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;gx-genomic-therapeutic-implication-crizotinib&quot; </p><p style="margin-bottom: 0px">Profile: <a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/StructureDefinition-therapeutic-implication.html">Therapeutic Implication</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Therapeutic Implication <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html">To Be Determined Codes</a>#therapeutic-implication)</span></p><p><b>subject</b>: <a href="#Patient_gx-cancer-patient-adam-anyperson">See above (Patient/gx-cancer-patient-adam-anyperson)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner/us-core-practitioner-owen-oncologist</a> &quot; ONCOLOGIST&quot;</p><p><b>derivedFrom</b>: <a href="#Observation_gx-genomic-variant-fusion-met-alk">See above (Observation/gx-genomic-variant-fusion-met-alk)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: 51963-7 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#51963-7)</span></p><p><b>value</b>: crizotinib <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-rxNorm.html">RxNorm</a>#1148495)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Predicted Therapeutic Implication <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html">To Be Determined Codes</a>#predicted-therapeutic-implication)</span></p><p><b>value</b>: Presumed responsive <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA9661-5)</span></p></blockquote></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
            <code value="therapeutic-implication"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <derivedFrom>
          <reference value="Observation/gx-genomic-variant-fusion-met-alk"/>
        </derivedFrom>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="51963-7"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.nlm.nih.gov/research/umls/rxnorm"/>
              <code value="1148495"/>
              <display value="crizotinib"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system
                      value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
              <code value="predicted-therapeutic-implication"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA9661-5"/>
              <display value="Presumed responsive"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-lorlatinib"/>
    <resource>
      <Observation>
        <id value="gx-genomic-therapeutic-implication-lorlatinib"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: Observation</b><a name="gx-genomic-therapeutic-implication-lorlatinib"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource Observation &quot;gx-genomic-therapeutic-implication-lorlatinib&quot; </p><p style="margin-bottom: 0px">Profile: <a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/StructureDefinition-therapeutic-implication.html">Therapeutic Implication</a></p></div><p><b>status</b>: final</p><p><b>category</b>: Laboratory <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-observation-category.html">Observation Category Codes</a>#laboratory)</span></p><p><b>code</b>: Therapeutic Implication <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html">To Be Determined Codes</a>#therapeutic-implication)</span></p><p><b>subject</b>: <a href="#Patient_gx-cancer-patient-adam-anyperson">See above (Patient/gx-cancer-patient-adam-anyperson)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner/us-core-practitioner-owen-oncologist</a> &quot; ONCOLOGIST&quot;</p><p><b>derivedFrom</b>: <a href="#Observation_gx-genomic-variant-fusion-met-alk">See above (Observation/gx-genomic-variant-fusion-met-alk)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: 51963-7 <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#51963-7)</span></p><p><b>value</b>: lorlatinib <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://terminology.hl7.org/5.3.0/CodeSystem-v3-rxNorm.html">RxNorm</a>#2103164)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: Predicted Therapeutic Implication <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="http://hl7.org/fhir/uv/genomics-reporting/STU2/CodeSystem-tbd-codes-cs.html">To Be Determined Codes</a>#predicted-therapeutic-implication)</span></p><p><b>value</b>: Presumed responsive <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="https://loinc.org/">LOINC</a>#LA9661-5)</span></p></blockquote></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
            <code value="therapeutic-implication"/>
          </coding>
        </code>
        <subject>
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>
          <reference
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