HL7 FHIR Implementation Guide: minimal Common Oncology Data Elements (mCODE) Release 1 - US Realm | STU Ballot 1

This page is part of the HL7 FHIR Implementation Guide: minimal Common Oncology Data Elements (mCODE) Release 1 - US Realm | STU1 (v0.9.1: STU 1 Ballot 1) based on FHIR R4. The current version which supercedes this version is 2.0.0. For a full list of available versions, see the Directory of published versions

VariantTested

@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

 a fhir:StructureDefinition;
  fhir:nodeRole fhir:treeRoot;
  fhir:Resource.id [ fhir:value "onco-core-VariantTested-extension"];
  fhir:DomainResource.text [
     fhir:Narrative.status [ fhir:value "generated" ];
     fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n  <p><b>VariantTested Extension</b></p>\n  <p>The specific genetic variant that is targeted by this test.</p>\n</div>"
  ];
  fhir:StructureDefinition.url [ fhir:value "http://hl7.org/fhir/us/mcode/StructureDefinition/onco-core-VariantTested-extension"];
  fhir:StructureDefinition.version [ fhir:value "0.9.1"];
  fhir:StructureDefinition.name [ fhir:value "VariantTested"];
  fhir:StructureDefinition.title [ fhir:value "onco-core-VariantTested"];
  fhir:StructureDefinition.status [ fhir:value "draft"];
  fhir:StructureDefinition.date [ fhir:value "2019-08-01T00:00:00-04:00"^^xsd:dateTime];
  fhir:StructureDefinition.publisher [ fhir:value "HL7 International Clinical Interoperability Council"];
  fhir:StructureDefinition.contact [
     fhir:index 0;
     fhir:ContactDetail.telecom [
       fhir:index 0;
       fhir:ContactPoint.system [ fhir:value "url" ];
       fhir:ContactPoint.value [ fhir:value "http://www.hl7.org/Special/committees/cic" ]     ]
  ];
  fhir:StructureDefinition.description [ fhir:value "The specific genetic variant that is targeted by this test."];
  fhir:StructureDefinition.fhirVersion [ fhir:value "4.0.0"];
  fhir:StructureDefinition.kind [ fhir:value "complex-type"];
  fhir:StructureDefinition.abstract [ fhir:value "false"^^xsd:boolean];
  fhir:StructureDefinition.context [
     fhir:index 0;
     fhir:StructureDefinition.context.type [ fhir:value "element" ];
     fhir:StructureDefinition.context.expression [ fhir:value "*" ]
  ];
  fhir:StructureDefinition.type [ fhir:value "Extension"];
  fhir:StructureDefinition.baseDefinition [
     fhir:value "http://hl7.org/fhir/StructureDefinition/Extension";
     fhir:link <http://hl7.org/fhir/StructureDefinition/Extension>
  ];
  fhir:StructureDefinition.derivation [ fhir:value "constraint"];
  fhir:StructureDefinition.snapshot [
     fhir:StructureDefinition.snapshot.element [
       fhir:index 0;
       fhir:Element.id [ fhir:value "Extension" ];
       fhir:ElementDefinition.path [ fhir:value "Extension" ];
       fhir:ElementDefinition.short [ fhir:value "VariantTested" ];
       fhir:ElementDefinition.definition [ fhir:value "The specific genetic variant that is targeted by this test." ];
       fhir:ElementDefinition.min [ fhir:value "0"^^xsd:nonNegativeInteger ];
       fhir:ElementDefinition.max [ fhir:value "*" ];
       fhir:ElementDefinition.base [
         fhir:ElementDefinition.base.path [ fhir:value "Extension" ];
         fhir:ElementDefinition.base.min [ fhir:value "0"^^xsd:nonNegativeInteger ];
         fhir:ElementDefinition.base.max [ fhir:value "*" ]       ];
       fhir:ElementDefinition.condition [
         fhir:value "ele-1";
         fhir:index 0       ];
       fhir:ElementDefinition.constraint [
         fhir:index 0;
         fhir:ElementDefinition.constraint.key [ fhir:value "ele-1" ];
         fhir:ElementDefinition.constraint.severity [ fhir:value "error" ];
         fhir:ElementDefinition.constraint.human [ fhir:value "All FHIR elements must have a @value or children" ];
         fhir:ElementDefinition.constraint.expression [ fhir:value "hasValue() or (children().count() > id.count())" ];
         fhir:ElementDefinition.constraint.xpath [ fhir:value "@value|f:*|h:div" ];
         fhir:ElementDefinition.constraint.source [ fhir:value "Element" ]       ], [
         fhir:index 1;
         fhir:ElementDefinition.constraint.key [ fhir:value "ext-1" ];
         fhir:ElementDefinition.constraint.severity [ fhir:value "error" ];
         fhir:ElementDefinition.constraint.human [ fhir:value "Must have either extensions or value[x], not both" ];
         fhir:ElementDefinition.constraint.expression [ fhir:value "extension.exists() != value.exists()" ];
         fhir:ElementDefinition.constraint.xpath [ fhir:value "exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])" ]       ];
       fhir:ElementDefinition.isModifier [ fhir:value "false"^^xsd:boolean ];
       fhir:ElementDefinition.mapping [
         fhir:index 0;
         fhir:ElementDefinition.mapping.identity [ fhir:value "rim" ];
         fhir:ElementDefinition.mapping.map [ fhir:value "n/a" ]       ], [
         fhir:index 1;
         fhir:ElementDefinition.mapping.identity [ fhir:value "rim" ];
         fhir:ElementDefinition.mapping.map [ fhir:value "N/A" ]       ]     ], [
       fhir:index 1;
       fhir:Element.id [ fhir:value "Extension.id" ];
       fhir:ElementDefinition.path [ fhir:value "Extension.id" ];
       fhir:ElementDefinition.representation [
         fhir:value "xmlAttr";
         fhir:index 0       ];
       fhir:ElementDefinition.short [ fhir:value "Unique id for inter-element referencing" ];
       fhir:ElementDefinition.definition [ fhir:value "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces." ];
       fhir:ElementDefinition.min [ fhir:value "0"^^xsd:nonNegativeInteger ];
       fhir:ElementDefinition.max [ fhir:value "1" ];
       fhir:ElementDefinition.base [
         fhir:ElementDefinition.base.path [ fhir:value "Element.id" ];
         fhir:ElementDefinition.base.min [ fhir:value "0"^^xsd:nonNegativeInteger ];
         fhir:ElementDefinition.base.max [ fhir:value "1" ]       ];
       fhir:ElementDefinition.type [
         fhir:index 0;
         fhir:ElementDefinition.type.code [ fhir:value "string" ]       ];
       fhir:ElementDefinition.isModifier [ fhir:value "false"^^xsd:boolean ];
       fhir:ElementDefinition.isSummary [ fhir:value "false"^^xsd:boolean ];
       fhir:ElementDefinition.mapping [
         fhir:index 0;
         fhir:ElementDefinition.mapping.identity [ fhir:value "rim" ];
         fhir:ElementDefinition.mapping.map [ fhir:value "n/a" ]       ]     ], [
       fhir:index 2;
       fhir:Element.id [ fhir:value "Extension.extension" ];
       fhir:ElementDefinition.path [ fhir:value "Extension.extension" ];
       fhir:ElementDefinition.slicing [
         fhir:ElementDefinition.slicing.discriminator [
           fhir:index 0;
           fhir:ElementDefinition.slicing.discriminator.type [ fhir:value "value" ];
           fhir:ElementDefinition.slicing.discriminator.path [ fhir:value "url" ]         ];
         fhir:ElementDefinition.slicing.description [ fhir:value "Extensions are always sliced by (at least) url" ];
         fhir:ElementDefinition.slicing.rules [ fhir:value "open" ]       ];
       fhir:ElementDefinition.short [ fhir:value "Additional content defined by implementations" ];
       fhir:ElementDefinition.definition [ fhir:value "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension." ];
       fhir:ElementDefinition.comment [ fhir:value "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone." ];
       fhir:ElementDefinition.alias [
         fhir:value "extensions";
         fhir:index 0       ], [
         fhir:value "user content";
         fhir:index 1       ];
       fhir:ElementDefinition.min [ fhir:value "0"^^xsd:nonNegativeInteger ];
       fhir:ElementDefinition.max [ fhir:value "*" ];
       fhir:ElementDefinition.base [
         fhir:ElementDefinition.base.path [ fhir:value "Element.extension" ];
         fhir:ElementDefinition.base.min [ fhir:value "0"^^xsd:nonNegativeInteger ];
         fhir:ElementDefinition.base.max [ fhir:value "*" ]       ];
       fhir:ElementDefinition.type [
         fhir:index 0;
         fhir:ElementDefinition.type.code [ fhir:value "Extension" ]       ];
       fhir:ElementDefinition.isModifier [ fhir:value "false"^^xsd:boolean ];
       fhir:ElementDefinition.isSummary [ fhir:value "false"^^xsd:boolean ];
       fhir:ElementDefinition.mapping [
         fhir:index 0;
         fhir:ElementDefinition.mapping.identity [ fhir:value "rim" ];
         fhir:ElementDefinition.mapping.map [ fhir:value "n/a" ]       ]     ], [
       fhir:index 3;
       fhir:Element.id [ fhir:value "Extension.extension:variantidentifier" ];
       fhir:ElementDefinition.path [ fhir:value "Extension.extension" ];
       fhir:ElementDefinition.sliceName [ fhir:value "variantidentifier" ];
       fhir:ElementDefinition.definition [ fhir:value "The variation ID assigned by HGVS, for example, 360448 is the identifier for NM_005228.4(EGFR):c.-237A>G (single nucleotide variant in EGFR)." ];
       fhir:ElementDefinition.min [ fhir:value "0"^^xsd:nonNegativeInteger ];
       fhir:ElementDefinition.max [ fhir:value "1" ];
       fhir:ElementDefinition.base [
         fhir:ElementDefinition.base.path [ fhir:value "Element.extension" ];
         fhir:ElementDefinition.base.min [ fhir:value "0"^^xsd:nonNegativeInteger ];
         fhir:ElementDefinition.base.max [ fhir:value "*" ]       ];
       fhir:ElementDefinition.type [
         fhir:index 0;
         fhir:ElementDefinition.type.code [ fhir:value "Extension" ];
         fhir:ElementDefinition.type.profile [
           fhir:value "http://hl7.org/fhir/us/mcode/StructureDefinition/onco-core-VariantIdentifier-extension";
           fhir:index 0;
           fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/onco-core-VariantIdentifier-extension>         ]       ];
       fhir:ElementDefinition.isModifier [ fhir:value "false"^^xsd:boolean ];
       fhir:ElementDefinition.isSummary [ fhir:value "false"^^xsd:boolean ];
       fhir:ElementDefinition.mapping [
         fhir:index 0;
         fhir:ElementDefinition.mapping.identity [ fhir:value "rim" ];
         fhir:ElementDefinition.mapping.map [ fhir:value "n/a" ]       ]     ], [
       fhir:index 4;
       fhir:Element.id [ fhir:value "Extension.extension:varianthgvsname" ];
       fhir:ElementDefinition.path [ fhir:value "Extension.extension" ];
       fhir:ElementDefinition.sliceName [ fhir:value "varianthgvsname" ];
       fhir:ElementDefinition.definition [ fhir:value "Symbolic representation of the variant used in HGVS, for example, NM_005228.4(EGFR):c.-237A>G for HVGS variation ID 360448." ];
       fhir:ElementDefinition.min [ fhir:value "0"^^xsd:nonNegativeInteger ];
       fhir:ElementDefinition.max [ fhir:value "*" ];
       fhir:ElementDefinition.base [
         fhir:ElementDefinition.base.path [ fhir:value "Element.extension" ];
         fhir:ElementDefinition.base.min [ fhir:value "0"^^xsd:nonNegativeInteger ];
         fhir:ElementDefinition.base.max [ fhir:value "*" ]       ];
       fhir:ElementDefinition.type [
         fhir:index 0;
         fhir:ElementDefinition.type.code [ fhir:value "Extension" ];
         fhir:ElementDefinition.type.profile [
           fhir:value "http://hl7.org/fhir/us/mcode/StructureDefinition/onco-core-VariantHGVSName-extension";
           fhir:index 0;
           fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/onco-core-VariantHGVSName-extension>         ]       ];
       fhir:ElementDefinition.isModifier [ fhir:value "false"^^xsd:boolean ];
       fhir:ElementDefinition.isSummary [ fhir:value "false"^^xsd:boolean ];
       fhir:ElementDefinition.mapping [
         fhir:index 0;
         fhir:ElementDefinition.mapping.identity [ fhir:value "rim" ];
         fhir:ElementDefinition.mapping.map [ fhir:value "n/a" ]       ]     ], [
       fhir:index 5;
       fhir:Element.id [ fhir:value "Extension.extension:variantdescription" ];
       fhir:ElementDefinition.path [ fhir:value "Extension.extension" ];
       fhir:ElementDefinition.sliceName [ fhir:value "variantdescription" ];
       fhir:ElementDefinition.definition [ fhir:value "A clinician-friendly description for the variant. This could be, but not limited to, the protein change associated with the variation. For example, the protein change associated with Clinvar 3236 is G482V." ];
       fhir:ElementDefinition.min [ fhir:value "0"^^xsd:nonNegativeInteger ];
       fhir:ElementDefinition.max [ fhir:value "1" ];
       fhir:ElementDefinition.base [
         fhir:ElementDefinition.base.path [ fhir:value "Element.extension" ];
         fhir:ElementDefinition.base.min [ fhir:value "0"^^xsd:nonNegativeInteger ];
         fhir:ElementDefinition.base.max [ fhir:value "*" ]       ];
       fhir:ElementDefinition.type [
         fhir:index 0;
         fhir:ElementDefinition.type.code [ fhir:value "Extension" ];
         fhir:ElementDefinition.type.profile [
           fhir:value "http://hl7.org/fhir/us/mcode/StructureDefinition/onco-core-VariantDescription-extension";
           fhir:index 0;
           fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/onco-core-VariantDescription-extension>         ]       ];
       fhir:ElementDefinition.isModifier [ fhir:value "false"^^xsd:boolean ];
       fhir:ElementDefinition.isSummary [ fhir:value "false"^^xsd:boolean ];
       fhir:ElementDefinition.mapping [
         fhir:index 0;
         fhir:ElementDefinition.mapping.identity [ fhir:value "rim" ];
         fhir:ElementDefinition.mapping.map [ fhir:value "n/a" ]       ]     ], [
       fhir:index 6;
       fhir:Element.id [ fhir:value "Extension.url" ];
       fhir:ElementDefinition.path [ fhir:value "Extension.url" ];
       fhir:ElementDefinition.representation [
         fhir:value "xmlAttr";
         fhir:index 0       ];
       fhir:ElementDefinition.short [ fhir:value "identifies the meaning of the extension" ];
       fhir:ElementDefinition.definition [ fhir:value "Source of the definition for the extension code - a logical name or a URL." ];
       fhir:ElementDefinition.comment [ fhir:value "The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension." ];
       fhir:ElementDefinition.min [ fhir:value "1"^^xsd:nonNegativeInteger ];
       fhir:ElementDefinition.max [ fhir:value "1" ];
       fhir:ElementDefinition.base [
         fhir:ElementDefinition.base.path [ fhir:value "Extension.url" ];
         fhir:ElementDefinition.base.min [ fhir:value "1"^^xsd:nonNegativeInteger ];
         fhir:ElementDefinition.base.max [ fhir:value "1" ]       ];
       fhir:ElementDefinition.type [
         fhir:index 0;
         fhir:ElementDefinition.type.code [ fhir:value "uri" ]       ];
       fhir:ElementDefinition.fixedUri [ fhir:value "http://hl7.org/fhir/us/mcode/StructureDefinition/onco-core-VariantTested-extension" ];
       fhir:ElementDefinition.isModifier [ fhir:value "false"^^xsd:boolean ];
       fhir:ElementDefinition.isSummary [ fhir:value "false"^^xsd:boolean ];
       fhir:ElementDefinition.mapping [
         fhir:index 0;
         fhir:ElementDefinition.mapping.identity [ fhir:value "rim" ];
         fhir:ElementDefinition.mapping.map [ fhir:value "N/A" ]       ]     ], [
       fhir:index 7;
       fhir:Element.id [ fhir:value "Extension.value[x]" ];
       fhir:ElementDefinition.path [ fhir:value "Extension.value[x]" ];
       fhir:ElementDefinition.short [ fhir:value "Value of extension" ];
       fhir:ElementDefinition.definition [ fhir:value "Value of extension - must be one of a constrained set of the data types (see [Extensibility](extensibility.html) for a list)." ];
       fhir:ElementDefinition.min [ fhir:value "0"^^xsd:nonNegativeInteger ];
       fhir:ElementDefinition.max [ fhir:value "0" ];
       fhir:ElementDefinition.base [
         fhir:ElementDefinition.base.path [ fhir:value "Extension.value[x]" ];
         fhir:ElementDefinition.base.min [ fhir:value "0"^^xsd:nonNegativeInteger ];
         fhir:ElementDefinition.base.max [ fhir:value "1" ]       ];
       fhir:ElementDefinition.type [
         fhir:index 0;
         fhir:ElementDefinition.type.code [ fhir:value "base64Binary" ]       ], [
         fhir:index 1;
         fhir:ElementDefinition.type.code [ fhir:value "boolean" ]       ], [
         fhir:index 2;
         fhir:ElementDefinition.type.code [ fhir:value "canonical" ]       ], [
         fhir:index 3;
         fhir:ElementDefinition.type.code [ fhir:value "code" ]       ], [
         fhir:index 4;
         fhir:ElementDefinition.type.code [ fhir:value "date" ]       ], [
         fhir:index 5;
         fhir:ElementDefinition.type.code [ fhir:value "dateTime" ]       ], [
         fhir:index 6;
         fhir:ElementDefinition.type.code [ fhir:value "decimal" ]       ], [
         fhir:index 7;
         fhir:ElementDefinition.type.code [ fhir:value "id" ]       ], [
         fhir:index 8;
         fhir:ElementDefinition.type.code [ fhir:value "instant" ]       ], [
         fhir:index 9;
         fhir:ElementDefinition.type.code [ fhir:value "integer" ]       ], [
         fhir:index 10;
         fhir:ElementDefinition.type.code [ fhir:value "markdown" ]       ], [
         fhir:index 11;
         fhir:ElementDefinition.type.code [ fhir:value "oid" ]       ], [
         fhir:index 12;
         fhir:ElementDefinition.type.code [ fhir:value "positiveInt" ]       ], [
         fhir:index 13;
         fhir:ElementDefinition.type.code [ fhir:value "string" ]       ], [
         fhir:index 14;
         fhir:ElementDefinition.type.code [ fhir:value "time" ]       ], [
         fhir:index 15;
         fhir:ElementDefinition.type.code [ fhir:value "unsignedInt" ]       ], [
         fhir:index 16;
         fhir:ElementDefinition.type.code [ fhir:value "uri" ]       ], [
         fhir:index 17;
         fhir:ElementDefinition.type.code [ fhir:value "url" ]       ], [
         fhir:index 18;
         fhir:ElementDefinition.type.code [ fhir:value "uuid" ]       ], [
         fhir:index 19;
         fhir:ElementDefinition.type.code [ fhir:value "Address" ]       ], [
         fhir:index 20;
         fhir:ElementDefinition.type.code [ fhir:value "Age" ]       ], [
         fhir:index 21;
         fhir:ElementDefinition.type.code [ fhir:value "Annotation" ]       ], [
         fhir:index 22;
         fhir:ElementDefinition.type.code [ fhir:value "Attachment" ]       ], [
         fhir:index 23;
         fhir:ElementDefinition.type.code [ fhir:value "CodeableConcept" ]       ], [
         fhir:index 24;
         fhir:ElementDefinition.type.code [ fhir:value "Coding" ]       ], [
         fhir:index 25;
         fhir:ElementDefinition.type.code [ fhir:value "ContactPoint" ]       ], [
         fhir:index 26;
         fhir:ElementDefinition.type.code [ fhir:value "Count" ]       ], [
         fhir:index 27;
         fhir:ElementDefinition.type.code [ fhir:value "Distance" ]       ], [
         fhir:index 28;
         fhir:ElementDefinition.type.code [ fhir:value "Duration" ]       ], [
         fhir:index 29;
         fhir:ElementDefinition.type.code [ fhir:value "HumanName" ]       ], [
         fhir:index 30;
         fhir:ElementDefinition.type.code [ fhir:value "Identifier" ]       ], [
         fhir:index 31;
         fhir:ElementDefinition.type.code [ fhir:value "Money" ]       ], [
         fhir:index 32;
         fhir:ElementDefinition.type.code [ fhir:value "Period" ]       ], [
         fhir:index 33;
         fhir:ElementDefinition.type.code [ fhir:value "Quantity" ]       ], [
         fhir:index 34;
         fhir:ElementDefinition.type.code [ fhir:value "Range" ]       ], [
         fhir:index 35;
         fhir:ElementDefinition.type.code [ fhir:value "Ratio" ]       ], [
         fhir:index 36;
         fhir:ElementDefinition.type.code [ fhir:value "Reference" ]       ], [
         fhir:index 37;
         fhir:ElementDefinition.type.code [ fhir:value "SampledData" ]       ], [
         fhir:index 38;
         fhir:ElementDefinition.type.code [ fhir:value "Signature" ]       ], [
         fhir:index 39;
         fhir:ElementDefinition.type.code [ fhir:value "Timing" ]       ], [
         fhir:index 40;
         fhir:ElementDefinition.type.code [ fhir:value "ContactDetail" ]       ], [
         fhir:index 41;
         fhir:ElementDefinition.type.code [ fhir:value "Contributor" ]       ], [
         fhir:index 42;
         fhir:ElementDefinition.type.code [ fhir:value "DataRequirement" ]       ], [
         fhir:index 43;
         fhir:ElementDefinition.type.code [ fhir:value "Expression" ]       ], [
         fhir:index 44;
         fhir:ElementDefinition.type.code [ fhir:value "ParameterDefinition" ]       ], [
         fhir:index 45;
         fhir:ElementDefinition.type.code [ fhir:value "RelatedArtifact" ]       ], [
         fhir:index 46;
         fhir:ElementDefinition.type.code [ fhir:value "TriggerDefinition" ]       ], [
         fhir:index 47;
         fhir:ElementDefinition.type.code [ fhir:value "UsageContext" ]       ], [
         fhir:index 48;
         fhir:ElementDefinition.type.code [ fhir:value "Dosage" ]       ];
       fhir:ElementDefinition.isModifier [ fhir:value "false"^^xsd:boolean ];
       fhir:ElementDefinition.isSummary [ fhir:value "false"^^xsd:boolean ];
       fhir:ElementDefinition.mapping [
         fhir:index 0;
         fhir:ElementDefinition.mapping.identity [ fhir:value "rim" ];
         fhir:ElementDefinition.mapping.map [ fhir:value "N/A" ]       ]     ]
  ];
  fhir:StructureDefinition.differential [
     fhir:StructureDefinition.differential.element [
       fhir:index 0;
       fhir:Element.id [ fhir:value "Extension" ];
       fhir:ElementDefinition.path [ fhir:value "Extension" ];
       fhir:ElementDefinition.short [ fhir:value "VariantTested" ];
       fhir:ElementDefinition.definition [ fhir:value "The specific genetic variant that is targeted by this test." ];
       fhir:ElementDefinition.min [ fhir:value "0"^^xsd:nonNegativeInteger ];
       fhir:ElementDefinition.max [ fhir:value "*" ]     ], [
       fhir:index 1;
       fhir:Element.id [ fhir:value "Extension.extension:variantidentifier" ];
       fhir:ElementDefinition.path [ fhir:value "Extension.extension" ];
       fhir:ElementDefinition.sliceName [ fhir:value "variantidentifier" ];
       fhir:ElementDefinition.definition [ fhir:value "The variation ID assigned by HGVS, for example, 360448 is the identifier for NM_005228.4(EGFR):c.-237A>G (single nucleotide variant in EGFR)." ];
       fhir:ElementDefinition.min [ fhir:value "0"^^xsd:nonNegativeInteger ];
       fhir:ElementDefinition.max [ fhir:value "1" ];
       fhir:ElementDefinition.base [
         fhir:ElementDefinition.base.path [ fhir:value "Element.extension" ];
         fhir:ElementDefinition.base.min [ fhir:value "0"^^xsd:nonNegativeInteger ];
         fhir:ElementDefinition.base.max [ fhir:value "*" ]       ];
       fhir:ElementDefinition.type [
         fhir:index 0;
         fhir:ElementDefinition.type.code [ fhir:value "Extension" ];
         fhir:ElementDefinition.type.profile [
           fhir:value "http://hl7.org/fhir/us/mcode/StructureDefinition/onco-core-VariantIdentifier-extension";
           fhir:index 0;
           fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/onco-core-VariantIdentifier-extension>         ]       ];
       fhir:ElementDefinition.isModifier [ fhir:value "false"^^xsd:boolean ];
       fhir:ElementDefinition.isSummary [ fhir:value "false"^^xsd:boolean ];
       fhir:ElementDefinition.mapping [
         fhir:index 0;
         fhir:ElementDefinition.mapping.identity [ fhir:value "rim" ];
         fhir:ElementDefinition.mapping.map [ fhir:value "n/a" ]       ]     ], [
       fhir:index 2;
       fhir:Element.id [ fhir:value "Extension.extension:varianthgvsname" ];
       fhir:ElementDefinition.path [ fhir:value "Extension.extension" ];
       fhir:ElementDefinition.sliceName [ fhir:value "varianthgvsname" ];
       fhir:ElementDefinition.definition [ fhir:value "Symbolic representation of the variant used in HGVS, for example, NM_005228.4(EGFR):c.-237A>G for HVGS variation ID 360448." ];
       fhir:ElementDefinition.min [ fhir:value "0"^^xsd:nonNegativeInteger ];
       fhir:ElementDefinition.max [ fhir:value "*" ];
       fhir:ElementDefinition.base [
         fhir:ElementDefinition.base.path [ fhir:value "Element.extension" ];
         fhir:ElementDefinition.base.min [ fhir:value "0"^^xsd:nonNegativeInteger ];
         fhir:ElementDefinition.base.max [ fhir:value "*" ]       ];
       fhir:ElementDefinition.type [
         fhir:index 0;
         fhir:ElementDefinition.type.code [ fhir:value "Extension" ];
         fhir:ElementDefinition.type.profile [
           fhir:value "http://hl7.org/fhir/us/mcode/StructureDefinition/onco-core-VariantHGVSName-extension";
           fhir:index 0;
           fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/onco-core-VariantHGVSName-extension>         ]       ];
       fhir:ElementDefinition.isModifier [ fhir:value "false"^^xsd:boolean ];
       fhir:ElementDefinition.isSummary [ fhir:value "false"^^xsd:boolean ];
       fhir:ElementDefinition.mapping [
         fhir:index 0;
         fhir:ElementDefinition.mapping.identity [ fhir:value "rim" ];
         fhir:ElementDefinition.mapping.map [ fhir:value "n/a" ]       ]     ], [
       fhir:index 3;
       fhir:Element.id [ fhir:value "Extension.extension:variantdescription" ];
       fhir:ElementDefinition.path [ fhir:value "Extension.extension" ];
       fhir:ElementDefinition.sliceName [ fhir:value "variantdescription" ];
       fhir:ElementDefinition.definition [ fhir:value "A clinician-friendly description for the variant. This could be, but not limited to, the protein change associated with the variation. For example, the protein change associated with Clinvar 3236 is G482V." ];
       fhir:ElementDefinition.min [ fhir:value "0"^^xsd:nonNegativeInteger ];
       fhir:ElementDefinition.max [ fhir:value "1" ];
       fhir:ElementDefinition.base [
         fhir:ElementDefinition.base.path [ fhir:value "Element.extension" ];
         fhir:ElementDefinition.base.min [ fhir:value "0"^^xsd:nonNegativeInteger ];
         fhir:ElementDefinition.base.max [ fhir:value "*" ]       ];
       fhir:ElementDefinition.type [
         fhir:index 0;
         fhir:ElementDefinition.type.code [ fhir:value "Extension" ];
         fhir:ElementDefinition.type.profile [
           fhir:value "http://hl7.org/fhir/us/mcode/StructureDefinition/onco-core-VariantDescription-extension";
           fhir:index 0;
           fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/onco-core-VariantDescription-extension>         ]       ];
       fhir:ElementDefinition.isModifier [ fhir:value "false"^^xsd:boolean ];
       fhir:ElementDefinition.isSummary [ fhir:value "false"^^xsd:boolean ];
       fhir:ElementDefinition.mapping [
         fhir:index 0;
         fhir:ElementDefinition.mapping.identity [ fhir:value "rim" ];
         fhir:ElementDefinition.mapping.map [ fhir:value "n/a" ]       ]     ], [
       fhir:index 4;
       fhir:Element.id [ fhir:value "Extension.url" ];
       fhir:ElementDefinition.path [ fhir:value "Extension.url" ];
       fhir:ElementDefinition.type [
         fhir:index 0;
         fhir:ElementDefinition.type.code [ fhir:value "uri" ]       ];
       fhir:ElementDefinition.fixedUri [ fhir:value "http://hl7.org/fhir/us/mcode/StructureDefinition/onco-core-VariantTested-extension" ]     ], [
       fhir:index 5;
       fhir:Element.id [ fhir:value "Extension.value[x]" ];
       fhir:ElementDefinition.path [ fhir:value "Extension.value[x]" ];
       fhir:ElementDefinition.min [ fhir:value "0"^^xsd:nonNegativeInteger ];
       fhir:ElementDefinition.max [ fhir:value "0" ]     ]
  ].

# - ontology header ------------------------------------------------------------

 a owl:Ontology;
  owl:imports fhir:fhir.ttl.