HL7 FHIR Implementation Guide: Breast Cancer Data, Release 1 - US Realm (Draft for Comment 2)
This page is part of the Breast Cancer Data Logical Models and FHIR Profiles (v0.2.0: STU 1 Draft) based on FHIR R3. . For a full list of available versions, see the Directory of published versions 
The official URL for this logical model is:
http://hl7.org/fhir/us/breastcancer/StructureDefinition/oncology-MitoticCountScore-model
The degree of mitotic activity in breast carcinoma is one component of the Nottingham histologic grade, which is a prognostic indicator for patients with breast carcinoma. Mitotic activity is assessed as the number of mitoses per 10 high power fields (HPF), with increasing mitotic activity being an indicator of more aggressive cancer. The specific scores assigned to the number of mitoses depends on the size of the HPF. For example, for a HPF size of 0.274 mm^2, less than 10 mitoses per 10 HPF gets a score of 1, 10-19 gets a score of 2, and greater than or equal to 20 gets a score of 3. When larger or smaller HPFs are used, the cutoffs for the number of mitoses corresponding to a specific score are adjusted according to published guidelines.
This logical model was published on Fri Aug 17 00:00:00 AEST 2018 as a draft by The HL7 Cancer Interoperability Group sponsored by Clinical Interoperability Council Work Group (CIC).
This IG does not define a corresponding profile for this logical model.
| Name | Flags | Card. | Type | Description & Constraints |
|---|---|---|---|---|
  oncology-MitoticCountScore-model | 0..* | |||
  value | 1..1 | Coding | Code representing the degree of mitotic activity in breast carcinoma is one component of the Nottingham histologic grade, which is a prognostic indicator for patients with breast carcinoma. Mitotic activity is assessed as the number of mitoses per 10 high power fields (HPF), with increasing mitotic activity being an indicator of more aggressive cancer. The specific scores assigned to the number of mitoses depends on the size of the HPF. For example, for a HPF size of 0.274 mm^2, less than 10 mitoses per 10 HPF gets a score of 1, 10-19 gets a score of 2, and greater than or equal to 20 gets a score of 3. When larger or smaller HPFs are used, the cutoffs for the number of mitoses corresponding to a specific score are adjusted according to published guidelines. Binding: LOINC Answer List LL4383-7 (required) | |
| topicCode | 0..1 | Coding | The concept representing the finding or action that is the topic of the statement. | |
| exceptionValue | 0..1 | Coding | Reason that a value associated with a test or other finding is missing. Binding: DataAbsentReason (extensible) | |
 interpretation | 0..1 | Coding | A clinical interpretation of a finding (applies to both assertions and observation). Binding: Observation Interpretation Codes (extensible) | |
| Documentation for this format | ||||
Downloads: StructureDefinition: (XML, JSON, TTL)
| Path | Name | Conformance | ValueSet |
| oncology-MitoticCountScore-model.value | LOINC LL4383-7 | required | LOINC LL4383-7 |
| oncology-MitoticCountScore-model.exceptionValue | DataAbsentReason | extensible | DataAbsentReason |
| oncology-MitoticCountScore-model.interpretation | Observation Interpretation Codes | extensible | Observation Interpretation Codes |