The EffectEvidenceSynthesis resource describes the difference in an outcome between exposures states in a population where the effect estimate is derived from a combination of research studies.

An absolute URI that is used to identify this effect evidence synthesis when it is referenced in a specification, model, design or an instance; also called its canonical identifier. This SHOULD be globally unique and SHOULD be a literal address at which at which an authoritative instance of this effect evidence synthesis is (or will be) published. This URL can be the target of a canonical reference. It SHALL remain the same when the effect evidence synthesis is stored on different servers.

Allows the effect evidence synthesis to be referenced by a single globally unique identifier.

Can be a urn:uuid: or a urn:oid: but real http: addresses are preferred. Multiple instances may share the same URL if they have a distinct version.

The determination of when to create a new version of a resource (same url, new version) vs. defining a new artifact is up to the author. Considerations for making this decision are found in Technical and Business Versions.

In some cases, the resource can no longer be found at the stated url, but the url itself cannot change. Implementations can use the meta.source element to indicate where the current master source of the resource can be found.

A formal identifier that is used to identify this effect evidence synthesis when it is represented in other formats, or referenced in a specification, model, design or an instance.

Allows externally provided and/or usable business identifiers to be easily associated with the module.

Typically, this is used for identifiers that can go in an HL7 V3 II (instance identifier) data type, and can then identify this effect evidence synthesis outside of FHIR, where it is not possible to use the logical URI.

The identifier that is used to identify this version of the effect evidence synthesis when it is referenced in a specification, model, design or instance. This is an arbitrary value managed by the effect evidence synthesis author and is not expected to be globally unique. For example, it might be a timestamp (e.g. yyyymmdd) if a managed version is not available. There is also no expectation that versions can be placed in a lexicographical sequence.

There may be different effect evidence synthesis instances that have the same identifier but different versions. The version can be appended to the url in a reference to allow a reference to a particular business version of the effect evidence synthesis with the format [url]|[version].

A natural language name identifying the effect evidence synthesis. This name should be usable as an identifier for the module by machine processing applications such as code generation.

Support human navigation and code generation.

The name is not expected to be globally unique. The name should be a simple alphanumeric type name to ensure that it is machine-processing friendly.

A short, descriptive, user-friendly title for the effect evidence synthesis.

This name does not need to be machine-processing friendly and may contain punctuation, white-space, etc.

The status of this effect evidence synthesis. Enables tracking the life-cycle of the content.

Allows filtering of effect evidence synthesiss that are appropriate for use versus not.

The date (and optionally time) when the effect evidence synthesis was published. The date must change when the business version changes and it must change if the status code changes. In addition, it should change when the substantive content of the effect evidence synthesis changes.

Note that this is not the same as the resource last-modified-date, since the resource may be a secondary representation of the effect evidence synthesis. Additional specific dates may be added as extensions or be found by consulting Provenances associated with past versions of the resource.

The name of the organization or individual that published the effect evidence synthesis.

Helps establish the "authority/credibility" of the effect evidence synthesis. May also allow for contact.

Usually an organization but may be an individual. The publisher (or steward) of the effect evidence synthesis is the organization or individual primarily responsible for the maintenance and upkeep of the effect evidence synthesis. This is not necessarily the same individual or organization that developed and initially authored the content. The publisher is the primary point of contact for questions or issues with the effect evidence synthesis. This item SHOULD be populated unless the information is available from context.

Contact details to assist a user in finding and communicating with the publisher.

May be a web site, an email address, a telephone number, etc.

A free text natural language description of the effect evidence synthesis from a consumer's perspective.

This description can be used to capture details such as why the effect evidence synthesis was built, comments about misuse, instructions for clinical use and interpretation, literature references, examples from the paper world, etc. It is not a rendering of the effect evidence synthesis as conveyed in the 'text' field of the resource itself. This item SHOULD be populated unless the information is available from context (e.g. the language of the effect evidence synthesis is presumed to be the predominant language in the place the effect evidence synthesis was created).

A human-readable string to clarify or explain concepts about the resource.

The content was developed with a focus and intent of supporting the contexts that are listed. These contexts may be general categories (gender, age, ...) or may be references to specific programs (insurance plans, studies, ...) and may be used to assist with indexing and searching for appropriate effect evidence synthesis instances.

Assist in searching for appropriate content.

When multiple useContexts are specified, there is no expectation that all or any of the contexts apply.

A legal or geographic region in which the effect evidence synthesis is intended to be used.

It may be possible for the effect evidence synthesis to be used in jurisdictions other than those for which it was originally designed or intended.

A copyright statement relating to the effect evidence synthesis and/or its contents. Copyright statements are generally legal restrictions on the use and publishing of the effect evidence synthesis.

Consumers must be able to determine any legal restrictions on the use of the effect evidence synthesis and/or its content.

The date on which the resource content was approved by the publisher. Approval happens once when the content is officially approved for usage.

The 'date' element may be more recent than the approval date because of minor changes or editorial corrections.

The date on which the resource content was last reviewed. Review happens periodically after approval but does not change the original approval date.

Gives a sense of how "current" the content is. Resources that have not been reviewed in a long time may have a risk of being less appropriate/relevant.

If specified, this date follows the original approval date.

The period during which the effect evidence synthesis content was or is planned to be in active use.

Allows establishing a transition before a resource comes into effect and also allows for a sunsetting process when new versions of the effect evidence synthesis are or are expected to be used instead.

The effective period for a effect evidence synthesis determines when the content is applicable for usage and is independent of publication and review dates. For example, a measure intended to be used for the year 2016 might be published in 2015.

Descriptive topics related to the content of the EffectEvidenceSynthesis. Topics provide a high-level categorization grouping types of EffectEvidenceSynthesiss that can be useful for filtering and searching.

Repositories must be able to determine how to categorize the EffectEvidenceSynthesis so that it can be found by topical searches.

An individiual or organization primarily involved in the creation and maintenance of the content.

An individual or organization primarily responsible for internal coherence of the content.

An individual or organization primarily responsible for review of some aspect of the content.

An individual or organization responsible for officially endorsing the content for use in some setting.

Related artifacts such as additional documentation, justification, or bibliographic references.

EffectEvidenceSynthesiss must be able to provide enough information for consumers of the content (and/or interventions or results produced by the content) to be able to determine and understand the justification for and evidence in support of the content.

Each related artifact is either an attachment, or a reference to another resource, but not both.

Type of synthesis eg meta-analysis.

Type of study eg randomized trial.

A reference to a EvidenceVariable resource that defines the population for the research.

A reference to a EvidenceVariable resource that defines the exposure for the research.

A reference to a EvidenceVariable resource that defines the comparison exposure for the research.

A reference to a EvidenceVariable resomece that defines the outcome for the research.

A description of the size of the sample involved in the synthesis.

Human-readable summary of sample size.

Number of studies included in this evidence synthesis.

Number of participants included in this evidence synthesis.

A description of the results for each exposure considered in the effect estimate.

Human-readable summary of results by exposure state.

Whether these results are for the exposure state or alternative exposure state.

Used to define variant exposure states such as low-risk state.

Reference to a RiskEvidenceSynthesis resource.

The estimated effect of the exposure variant.

Human-readable summary of effect estimate.

Examples include relative risk and mean difference.

Used to define variant exposure states such as low-risk state.

The point estimate of the effect estimate.

Specifies the UCUM unit for the outcome.

A description of the precision of the estimate for the effect.

Examples include confidence interval and interquartile range.

Use 95 for a 95% confidence interval.

Lower bound of confidence interval.

Upper bound of confidence interval.

A description of the certainty of the effect estimate.

A rating of the certainty of the effect estimate.

A human-readable string to clarify or explain concepts about the resource.

A description of a component of the overall certainty.

Type of subcomponent of certainty rating.

A rating of a subcomponent of rating certainty.

A human-readable string to clarify or explain concepts about the resource.