This page is part of the FHIR Specification (v5.0.0: R5 - STU). This is the current published version in it's permanent home (it will always be available at this URL). For a full list of available versions, see the Directory of published versions . Page versions: R5 R4B
Clinical Decision Support Work Group | Maturity Level: N/A | Standards Status: Informative | Compartments: No defined compartments |
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Effect of Alteplase vs No alteplase on mRS 3-6 at 90 days in Stroke 0-3 hours prior (id = "example-stroke-0-3-alteplase-vs-no-alteplase-mRS3-6")
<?xml version="1.0" encoding="UTF-8"?> <Evidence xmlns="http://hl7.org/fhir"> <id value="example-stroke-0-3-alteplase-vs-no-alteplase-mRS3-6"/> <text> <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml"> <p> "Effect of Alteplase vs No alteplase on mRS 3-6 at 90 days in Stroke 0-3 hours prior" is a comparative effect estimate. </p> </div> </text> <url value="http://hl7.org/fhir/Evidence/example-stroke-0-3-alteplase-vs-no-alteplase-mRS3-6"/> <identifier> <system value="urn:ietf:rfc:3986"/> <value value="urn:oid:2.16.840.1.113883.4.642.10.5"/> </identifier> <name value="EffectOfAlteplaseVsNoAlteplaseOnMRS36At90DaysInStroke03HoursPrior"/> <title value="Effect of Alteplase vs No alteplase on mRS 3-6 at 90 days in Stroke 0-3 hours prior"/> <status value="draft"/> <relatedArtifact> <type value="citation"/> <label value="Wardlaw 2014"/> <display value="Analysis 1.16 from Wardlaw 2014"/> <citation value="Wardlaw JM, Murray V, Berge E, del Zoppo GJ. Thrombolysis for acute ischaemic stroke. Cochrane Database Syst Rev. 2014 Jul 29(7):CD000213. PMID 25072528"/> <document> <url value="https://doi.org/10.1002/14651858.CD000213.pub3"/> </document> </relatedArtifact> <description value="mRS 3-6 at 90 days Odds Ratio 0.65 for Alteplase vs. No Alteplase in patients with acute ischemic stroke 0-3 hours prior"/> <variableDefinition> <variableRole> <coding> <system value="http://terminology.hl7.org/CodeSystem/variable-role"/> <code value="population"/> <display value="population"/> </coding> </variableRole> <observed> <reference value="EvidenceVariable/Wardlaw2014Analysis1.16.3EvidenceSet"/> <type value="EvidenceVariable"/> <display value="Wardlaw 2014 Analysis 1.16.3 Evidence set"/> </observed> <intended> <reference value="Group/AcuteIschemicStroke0-3Hours"/> <type value="Group"/> <display value="stroke at 0-3 hours"/> </intended> </variableDefinition> <variableDefinition> <variableRole> <coding> <system value="http://terminology.hl7.org/CodeSystem/variable-role"/> <code value="measuredVariable"/> <display value="measured variable"/> </coding> </variableRole> <observed> <reference value="EvidenceVariable/example-mRS3-6-at-90days"/> <type value="EvidenceVariable"/> <display value="mRS 3-6 at 90 days"/> </observed> <intended> <reference value="EvidenceVariable/example-dead-or-dependent-90day"/> <type value="EvidenceVariable"/> <display value="Dead or functionally dependent at 90 days"/> </intended> </variableDefinition> <variableDefinition> <variableRole> <coding> <system value="http://terminology.hl7.org/CodeSystem/variable-role"/> <code value="exposure"/> <display value="exposure"/> </coding> </variableRole> <observed> <reference value="EvidenceVariable/example-alteplase-for-stroke"/> <type value="EvidenceVariable"/> <display value="Alteplase for Stroke"/> </observed> <intended> <reference value="EvidenceVariable/example-alteplase-for-stroke"/> <type value="EvidenceVariable"/> <display value="Alteplase for Stroke"/> </intended> </variableDefinition> <variableDefinition> <variableRole> <coding> <system value="http://terminology.hl7.org/CodeSystem/variable-role"/> <code value="referenceExposure"/> <display value="reference exposure"/> </coding> </variableRole> <observed> <reference value="EvidenceVariable/example-no-alteplase"/> <type value="EvidenceVariable"/> <display value="no alteplase"/> </observed> <intended> <reference value="EvidenceVariable/example-no-alteplase"/> <type value="EvidenceVariable"/> <display value="no alteplase"/> </intended> </variableDefinition> <synthesisType> <coding> <system value="http://terminology.hl7.org/CodeSystem/synthesis-type"/> <code value="std-MA"/> <display value="summary data meta-analysis"/> </coding> </synthesisType> <studyDesign> <coding> <system value="http://hl7.org/fhir/study-design"/> <code value="SEVCO:01003"/> <display value="randomized assignment"/> </coding> </studyDesign> <statistic> <statisticType> <coding> <system value="http://terminology.hl7.org/CodeSystem/statistic-type"/> <code value="C16932"/> <display value="Odds Ratio"/> </coding> </statisticType> <quantity> <value value="0.65"/> </quantity> <numberOfEvents value="1137"/> <sampleSize> <numberOfStudies value="6"/> <numberOfParticipants value="1779"/> </sampleSize> <attributeEstimate> <description value="95% CI 0.54 to 0.80"/> <type> <coding> <system value="http://terminology.hl7.org/CodeSystem/attribute-estimate-type"/> <code value="C53324"/> <display value="Confidence interval"/> </coding> </type> <level value="0.95"/> <range> <low> <value value="0.54"/> </low> <high> <value value="0.8"/> </high> </range> </attributeEstimate> <attributeEstimate> <description value="P-value = 0.000023"/> <type> <coding> <system value="http://terminology.hl7.org/CodeSystem/attribute-estimate-type"/> <code value="C44185"/> <display value="P-value"/> </coding> </type> <quantity> <value value="0.000023"/> </quantity> </attributeEstimate> <attributeEstimate> <description value="Heterogeneity I-sq = 0.0%"/> <type> <coding> <system value="http://terminology.hl7.org/CodeSystem/attribute-estimate-type"/> <code value="0000420"/> <display value="I-squared"/> </coding> </type> <quantity> <value value="0"/> <unit value="%"/> <system value="http://unitsofmeasure.org"/> <code value="%"/> </quantity> </attributeEstimate> </statistic> <certainty> <description value="Moderate certainty due to risk of bias"/> <type> <coding> <system value="http://hl7.org/fhir/certainty-type"/> <code value="Overall"/> <display value="Overall quality"/> </coding> </type> <rating> <coding> <system value="http://hl7.org/fhir/certainty-rating"/> <code value="moderate"/> <display value="Moderate"/> </coding> </rating> <subcomponent> <type> <coding> <system value="http://hl7.org/fhir/certainty-type"/> <code value="PublicationBias"/> <display value="Publication bias"/> </coding> </type> <rating> <coding> <system value="http://hl7.org/fhir/certainty-rating"/> <code value="no-concern"/> <display value="no serious concern"/> </coding> </rating> </subcomponent> <subcomponent> <type> <coding> <system value="http://hl7.org/fhir/certainty-type"/> <code value="Inconsistency"/> <display value="Inconsistency"/> </coding> </type> <rating> <coding> <system value="http://hl7.org/fhir/certainty-rating"/> <code value="no-concern"/> <display value="no serious concern"/> </coding> </rating> </subcomponent> <subcomponent> <type> <coding> <system value="http://hl7.org/fhir/certainty-type"/> <code value="Imprecision"/> <display value="Imprecision"/> </coding> </type> <rating> <coding> <system value="http://hl7.org/fhir/certainty-rating"/> <code value="no-concern"/> <display value="no serious concern"/> </coding> </rating> </subcomponent> <subcomponent> <type> <coding> <system value="http://hl7.org/fhir/certainty-type"/> <code value="Indirectness"/> <display value="Indirectness"/> </coding> </type> <rating> <coding> <system value="http://hl7.org/fhir/certainty-rating"/> <code value="no-concern"/> <display value="no serious concern"/> </coding> </rating> </subcomponent> <subcomponent> <note> <text value="results largely influenced by IST-3 trial which was unblinded and NINDS trial which had allocation concealment not stated and baseline imbalances"/> </note> <type> <coding> <system value="http://hl7.org/fhir/certainty-type"/> <code value="RiskOfBias"/> <display value="Risk of bias"/> </coding> </type> <rating> <coding> <system value="http://hl7.org/fhir/certainty-rating"/> <code value="serious-concern"/> <display value="serious concern"/> </coding> </rating> </subcomponent> </certainty> </Evidence>
Usage note: every effort has been made to ensure that the examples are correct and useful, but they are not a normative part of the specification.
FHIR ®© HL7.org 2011+. FHIR R5 hl7.fhir.core#5.0.0 generated on Sun, Mar 26, 2023 15:24+1100.
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