A single issue - either an indication, contraindication, interaction or an undesirable effect for a medicinal product, medication, device or procedure.

Business identifier for this issue.

indication | contraindication | interaction | undesirable-effect | warning.

A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy and Lactation", "Overdose", "Effects on Ability to Drive and Use Machines".

The medication or procedure for which this is an indication.

Whether this is a current issue or one that has been retired etc.

General description of an effect (particularly for a general warning, rather than any of the more specific types such as indication) for when a distinct coded or textual description is not appropriate using Indication.diseaseSymptomProcedure.text, Contraindication.diseaseSymptomProcedure.text etc. For example "May affect ability to drive".

Specifics for when this is a contraindication.

The situation that is being documented as contraindicating against this item.

The status of the disease or symptom for the contraindication.

A comorbidity (concurrent condition) or coinfection.

The indication which this is a contraidication for.

Information about the use of the medicinal product in relation to other therapies described as part of the contraindication.

The type of relationship between the medicinal product indication or contraindication and another therapy.

Reference to a specific medication (active substance, medicinal product or class of products) as part of an indication or contraindication.

Specifics for when this is an indication.

The situation that is being documented as an indicaton for this item.

The status of the disease or symptom for the indication.

A comorbidity (concurrent condition) or coinfection as part of the indication.

The intended effect, aim or strategy to be achieved.

Timing or duration information.

The specific undesirable effects of the medicinal product.

Information about the use of the medicinal product in relation to other therapies described as part of the indication.

Specifics for when this is an interaction.

The specific medication, food, substance or laboratory test that interacts.

The specific medication, food or laboratory test that interacts.

The type of the interaction e.g. drug-drug interaction, drug-food interaction, drug-lab test interaction.

The effect of the interaction, for example "reduced gastric absorption of primary medication".

The incidence of the interaction, e.g. theoretical, observed.

Actions for managing the interaction.

The population group to which this applies.

Describe the undesirable effects of the medicinal product.

The situation in which the undesirable effect may manifest.

High level classification of the effect.

How often the effect is seen.