This page is part of the FHIR Specification (v3.5.0: R4 Ballot #2). The current version which supercedes this version is 5.0.0. For a full list of available versions, see the Directory of published versions

11.10 Resource MedicinalProductContraindication - Content

Biomedical Research and Regulation

Work Group

Maturity Level: 0

Trial Use

Compartments: Not linked to any defined compartments

The clinical particulars - indications, contraindications etc. of a medicinal product, including for regulatory purposes.

11.10.1 Scope and Usage

A reason why a medicinal product is not to be used in a certain context

This resource is referenced by MedicinalProduct

Structure

Name	Flags	Card.	Type	Description & Constraints
MedicinalProductContraindication	Σ TU		DomainResource	MedicinalProductContraindication Elements defined in Ancestors: id, meta, implicitRules, language, text, contained, extension, modifierExtension
subject	Σ	0..*	Reference(MedicinalProduct \| Medication)	The medication for which this is an indication
disease	Σ	0..1	CodeableConcept	The disease, symptom or procedure for the contraindication
diseaseStatus	Σ	0..1	CodeableConcept	The status of the disease or symptom for the contraindication
comorbidity	Σ	0..*	CodeableConcept	A comorbidity (concurrent condition) or coinfection
therapeuticIndication	Σ	0..*	Reference(MedicinalProductIndication)	Information about the use of the medicinal product in relation to other therapies as part of the indication
otherTherapy	Σ	0..*	BackboneElement	Information about the use of the medicinal product in relation to other therapies described as part of the indication
therapyRelationshipType	Σ	1..1	CodeableConcept	The type of relationship between the medicinal product indication or contraindication and another therapy
medication[x]	Σ	1..1		Reference to a specific medication (active substance, medicinal product or class of products) as part of an indication or contraindication
medicationCodeableConcept			CodeableConcept
medicationReference			Reference(MedicinalProduct \| Medication \| Substance \| SubstanceSpecification)
population	Σ	0..*	BackboneElement	The population group to which this applies
age[x]	Σ	0..1		The age of the specific population
ageRange			Range
ageCodeableConcept			CodeableConcept
gender	Σ	0..1	CodeableConcept	The gender of the specific population
race	Σ	0..1	CodeableConcept	Race of the specific population
physiologicalCondition	Σ	0..1	CodeableConcept	The existing physiological conditions of the specific population to which this applies
Documentation for this format

UML Diagram (Legend)

XML Template

<MedicinalProductContraindication xmlns="http://hl7.org/fhir"> 
 <!-- from Resource: id, meta, implicitRules, and language -->
 <!-- from DomainResource: text, contained, extension, and modifierExtension -->
 <subject><!-- 0..* Reference(MedicinalProduct|Medication) The medication for which this is an indication --></subject>
 <disease><!-- 0..1 CodeableConcept The disease, symptom or procedure for the contraindication --></disease>
 <diseaseStatus><!-- 0..1 CodeableConcept The status of the disease or symptom for the contraindication --></diseaseStatus>
 <comorbidity><!-- 0..* CodeableConcept A comorbidity (concurrent condition) or coinfection --></comorbidity>
 <therapeuticIndication><!-- 0..* Reference(MedicinalProductIndication) Information about the use of the medicinal product in relation to other therapies as part of the indication --></therapeuticIndication>
 <otherTherapy>  <!-- 0..* Information about the use of the medicinal product in relation to other therapies described as part of the indication -->
  <therapyRelationshipType><!-- 1..1 CodeableConcept The type of relationship between the medicinal product indication or contraindication and another therapy --></therapyRelationshipType>
  <medication[x]><!-- 1..1 CodeableConcept|Reference(MedicinalProduct|Medication|
    Substance|SubstanceSpecification) Reference to a specific medication (active substance, medicinal product or class of products) as part of an indication or contraindication --></medication[x]>
 </otherTherapy>
 <population>  <!-- 0..* The population group to which this applies -->
  <age[x]><!-- 0..1 Range|CodeableConcept The age of the specific population --></age[x]>
  <gender><!-- 0..1 CodeableConcept The gender of the specific population --></gender>
  <race><!-- 0..1 CodeableConcept Race of the specific population --></race>
  <physiologicalCondition><!-- 0..1 CodeableConcept The existing physiological conditions of the specific population to which this applies --></physiologicalCondition>
 </population>
</MedicinalProductContraindication>

JSON Template

{
  "resourceType" : "MedicinalProductContraindication",
  // from Resource: id, meta, implicitRules, and language
  // from DomainResource: text, contained, extension, and modifierExtension
  "subject" : [{ Reference(MedicinalProduct|Medication) }], // The medication for which this is an indication
  "disease" : { CodeableConcept }, // The disease, symptom or procedure for the contraindication
  "diseaseStatus" : { CodeableConcept }, // The status of the disease or symptom for the contraindication
  "comorbidity" : [{ CodeableConcept }], // A comorbidity (concurrent condition) or coinfection
  "therapeuticIndication" : [{ Reference(MedicinalProductIndication) }], // Information about the use of the medicinal product in relation to other therapies as part of the indication
  "otherTherapy" : [{ // Information about the use of the medicinal product in relation to other therapies described as part of the indication
    "therapyRelationshipType" : { CodeableConcept }, // R!  The type of relationship between the medicinal product indication or contraindication and another therapy
    // medication[x]: 
      Reference to a specific medication (active substance, medicinal product or class of products) as part of an indication or contraindication. One of these 2:
    "medicationCodeableConcept" : { CodeableConcept }
    "medicationReference" : { Reference(MedicinalProduct|Medication|Substance|
    SubstanceSpecification) }
  }],
  "population" : [{ // The population group to which this applies
    // age[x]: The age of the specific population. One of these 2:
    "ageRange" : { Range },
    "ageCodeableConcept" : { CodeableConcept },
    "gender" : { CodeableConcept }, // The gender of the specific population
    "race" : { CodeableConcept }, // Race of the specific population
    "physiologicalCondition" : { CodeableConcept } // The existing physiological conditions of the specific population to which this applies
  }]
}

Turtle Template

@prefix fhir: <http://hl7.org/fhir/> .


[ a fhir:MedicinalProductContraindication;
  fhir:nodeRole fhir:treeRoot; # if this is the parser root

  # from Resource: .id, .meta, .implicitRules, and .language
  # from DomainResource: .text, .contained, .extension, and .modifierExtension
  fhir:MedicinalProductContraindication.subject [ Reference(MedicinalProduct|Medication) ], ... ; # 0..* The medication for which this is an indication
  fhir:MedicinalProductContraindication.disease [ CodeableConcept ]; # 0..1 The disease, symptom or procedure for the contraindication
  fhir:MedicinalProductContraindication.diseaseStatus [ CodeableConcept ]; # 0..1 The status of the disease or symptom for the contraindication
  fhir:MedicinalProductContraindication.comorbidity [ CodeableConcept ], ... ; # 0..* A comorbidity (concurrent condition) or coinfection
  fhir:MedicinalProductContraindication.therapeuticIndication [ Reference(MedicinalProductIndication) ], ... ; # 0..* Information about the use of the medicinal product in relation to other therapies as part of the indication
  fhir:MedicinalProductContraindication.otherTherapy [ # 0..* Information about the use of the medicinal product in relation to other therapies described as part of the indication
    fhir:MedicinalProductContraindication.otherTherapy.therapyRelationshipType [ CodeableConcept ]; # 1..1 The type of relationship between the medicinal product indication or contraindication and another therapy
    # MedicinalProductContraindication.otherTherapy.medication[x] : 1..1 Reference to a specific medication (active substance, medicinal product or class of products) as part of an indication or contraindication. One of these 2
      fhir:MedicinalProductContraindication.otherTherapy.medicationCodeableConcept [ CodeableConcept ]
      fhir:MedicinalProductContraindication.otherTherapy.medicationReference [ Reference(MedicinalProduct|Medication|Substance|SubstanceSpecification) ]
  ], ...;
  fhir:MedicinalProductContraindication.population [ # 0..* The population group to which this applies
    # MedicinalProductContraindication.population.age[x] : 0..1 The age of the specific population. One of these 2
      fhir:MedicinalProductContraindication.population.ageRange [ Range ]
      fhir:MedicinalProductContraindication.population.ageCodeableConcept [ CodeableConcept ]
    fhir:MedicinalProductContraindication.population.gender [ CodeableConcept ]; # 0..1 The gender of the specific population
    fhir:MedicinalProductContraindication.population.race [ CodeableConcept ]; # 0..1 Race of the specific population
    fhir:MedicinalProductContraindication.population.physiologicalCondition [ CodeableConcept ]; # 0..1 The existing physiological conditions of the specific population to which this applies
  ], ...;
]

Changes since R3

This resource did not exist in Release 2

This analysis is available as XML or JSON.

Structure

Name	Flags	Card.	Type	Description & Constraints
MedicinalProductContraindication	Σ TU		DomainResource	MedicinalProductContraindication Elements defined in Ancestors: id, meta, implicitRules, language, text, contained, extension, modifierExtension
subject	Σ	0..*	Reference(MedicinalProduct \| Medication)	The medication for which this is an indication
disease	Σ	0..1	CodeableConcept	The disease, symptom or procedure for the contraindication
diseaseStatus	Σ	0..1	CodeableConcept	The status of the disease or symptom for the contraindication
comorbidity	Σ	0..*	CodeableConcept	A comorbidity (concurrent condition) or coinfection
therapeuticIndication	Σ	0..*	Reference(MedicinalProductIndication)	Information about the use of the medicinal product in relation to other therapies as part of the indication
otherTherapy	Σ	0..*	BackboneElement	Information about the use of the medicinal product in relation to other therapies described as part of the indication
therapyRelationshipType	Σ	1..1	CodeableConcept	The type of relationship between the medicinal product indication or contraindication and another therapy
medication[x]	Σ	1..1		Reference to a specific medication (active substance, medicinal product or class of products) as part of an indication or contraindication
medicationCodeableConcept			CodeableConcept
medicationReference			Reference(MedicinalProduct \| Medication \| Substance \| SubstanceSpecification)
population	Σ	0..*	BackboneElement	The population group to which this applies
age[x]	Σ	0..1		The age of the specific population
ageRange			Range
ageCodeableConcept			CodeableConcept
gender	Σ	0..1	CodeableConcept	The gender of the specific population
race	Σ	0..1	CodeableConcept	Race of the specific population
physiologicalCondition	Σ	0..1	CodeableConcept	The existing physiological conditions of the specific population to which this applies
Documentation for this format

UML Diagram (Legend)

XML Template

<MedicinalProductContraindication xmlns="http://hl7.org/fhir"> 
 <!-- from Resource: id, meta, implicitRules, and language -->
 <!-- from DomainResource: text, contained, extension, and modifierExtension -->
 <subject><!-- 0..* Reference(MedicinalProduct|Medication) The medication for which this is an indication --></subject>
 <disease><!-- 0..1 CodeableConcept The disease, symptom or procedure for the contraindication --></disease>
 <diseaseStatus><!-- 0..1 CodeableConcept The status of the disease or symptom for the contraindication --></diseaseStatus>
 <comorbidity><!-- 0..* CodeableConcept A comorbidity (concurrent condition) or coinfection --></comorbidity>
 <therapeuticIndication><!-- 0..* Reference(MedicinalProductIndication) Information about the use of the medicinal product in relation to other therapies as part of the indication --></therapeuticIndication>
 <otherTherapy>  <!-- 0..* Information about the use of the medicinal product in relation to other therapies described as part of the indication -->
  <therapyRelationshipType><!-- 1..1 CodeableConcept The type of relationship between the medicinal product indication or contraindication and another therapy --></therapyRelationshipType>
  <medication[x]><!-- 1..1 CodeableConcept|Reference(MedicinalProduct|Medication|
    Substance|SubstanceSpecification) Reference to a specific medication (active substance, medicinal product or class of products) as part of an indication or contraindication --></medication[x]>
 </otherTherapy>
 <population>  <!-- 0..* The population group to which this applies -->
  <age[x]><!-- 0..1 Range|CodeableConcept The age of the specific population --></age[x]>
  <gender><!-- 0..1 CodeableConcept The gender of the specific population --></gender>
  <race><!-- 0..1 CodeableConcept Race of the specific population --></race>
  <physiologicalCondition><!-- 0..1 CodeableConcept The existing physiological conditions of the specific population to which this applies --></physiologicalCondition>
 </population>
</MedicinalProductContraindication>

JSON Template

{
  "resourceType" : "MedicinalProductContraindication",
  // from Resource: id, meta, implicitRules, and language
  // from DomainResource: text, contained, extension, and modifierExtension
  "subject" : [{ Reference(MedicinalProduct|Medication) }], // The medication for which this is an indication
  "disease" : { CodeableConcept }, // The disease, symptom or procedure for the contraindication
  "diseaseStatus" : { CodeableConcept }, // The status of the disease or symptom for the contraindication
  "comorbidity" : [{ CodeableConcept }], // A comorbidity (concurrent condition) or coinfection
  "therapeuticIndication" : [{ Reference(MedicinalProductIndication) }], // Information about the use of the medicinal product in relation to other therapies as part of the indication
  "otherTherapy" : [{ // Information about the use of the medicinal product in relation to other therapies described as part of the indication
    "therapyRelationshipType" : { CodeableConcept }, // R!  The type of relationship between the medicinal product indication or contraindication and another therapy
    // medication[x]: 
      Reference to a specific medication (active substance, medicinal product or class of products) as part of an indication or contraindication. One of these 2:
    "medicationCodeableConcept" : { CodeableConcept }
    "medicationReference" : { Reference(MedicinalProduct|Medication|Substance|
    SubstanceSpecification) }
  }],
  "population" : [{ // The population group to which this applies
    // age[x]: The age of the specific population. One of these 2:
    "ageRange" : { Range },
    "ageCodeableConcept" : { CodeableConcept },
    "gender" : { CodeableConcept }, // The gender of the specific population
    "race" : { CodeableConcept }, // Race of the specific population
    "physiologicalCondition" : { CodeableConcept } // The existing physiological conditions of the specific population to which this applies
  }]
}

Turtle Template

@prefix fhir: <http://hl7.org/fhir/> .


[ a fhir:MedicinalProductContraindication;
  fhir:nodeRole fhir:treeRoot; # if this is the parser root

  # from Resource: .id, .meta, .implicitRules, and .language
  # from DomainResource: .text, .contained, .extension, and .modifierExtension
  fhir:MedicinalProductContraindication.subject [ Reference(MedicinalProduct|Medication) ], ... ; # 0..* The medication for which this is an indication
  fhir:MedicinalProductContraindication.disease [ CodeableConcept ]; # 0..1 The disease, symptom or procedure for the contraindication
  fhir:MedicinalProductContraindication.diseaseStatus [ CodeableConcept ]; # 0..1 The status of the disease or symptom for the contraindication
  fhir:MedicinalProductContraindication.comorbidity [ CodeableConcept ], ... ; # 0..* A comorbidity (concurrent condition) or coinfection
  fhir:MedicinalProductContraindication.therapeuticIndication [ Reference(MedicinalProductIndication) ], ... ; # 0..* Information about the use of the medicinal product in relation to other therapies as part of the indication
  fhir:MedicinalProductContraindication.otherTherapy [ # 0..* Information about the use of the medicinal product in relation to other therapies described as part of the indication
    fhir:MedicinalProductContraindication.otherTherapy.therapyRelationshipType [ CodeableConcept ]; # 1..1 The type of relationship between the medicinal product indication or contraindication and another therapy
    # MedicinalProductContraindication.otherTherapy.medication[x] : 1..1 Reference to a specific medication (active substance, medicinal product or class of products) as part of an indication or contraindication. One of these 2
      fhir:MedicinalProductContraindication.otherTherapy.medicationCodeableConcept [ CodeableConcept ]
      fhir:MedicinalProductContraindication.otherTherapy.medicationReference [ Reference(MedicinalProduct|Medication|Substance|SubstanceSpecification) ]
  ], ...;
  fhir:MedicinalProductContraindication.population [ # 0..* The population group to which this applies
    # MedicinalProductContraindication.population.age[x] : 0..1 The age of the specific population. One of these 2
      fhir:MedicinalProductContraindication.population.ageRange [ Range ]
      fhir:MedicinalProductContraindication.population.ageCodeableConcept [ CodeableConcept ]
    fhir:MedicinalProductContraindication.population.gender [ CodeableConcept ]; # 0..1 The gender of the specific population
    fhir:MedicinalProductContraindication.population.race [ CodeableConcept ]; # 0..1 Race of the specific population
    fhir:MedicinalProductContraindication.population.physiologicalCondition [ CodeableConcept ]; # 0..1 The existing physiological conditions of the specific population to which this applies
  ], ...;
]

Changes since Release 3

This resource did not exist in Release 2

This analysis is available as XML or JSON.

See the Profiles & Extensions and the alternate definitions: Master Definition XML + JSON, XML Schema/Schematron + JSON Schema, ShEx (for Turtle) + see the extensions & the dependency analysis

11.10.3 Search Parameters

Search parameters for this resource. The common parameters also apply. See Searching for more information about searching in REST, messaging, and services.

Name	Type	Description	Expression	In Common
subject	reference	The medication for which this is an contraindication	MedicinalProductContraindication.subject (Medication, MedicinalProduct)