Evidence Based Medicine on FHIR Implementation Guide
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This page is part of the Evidence Based Medicine on FHIR Implementation Guide (v1.0.0-ballot2: STU1 Ballot 2) based on FHIR (HL7® FHIR® Standard) v6.0.0. No current official version has been published yet. For a full list of available versions, see the Directory of published versions

: NetEffectContribution: Remission of diabetes for Example for GIN 2022 - JSON Representation

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{
  "resourceType" : "Evidence",
  "id" : "179588",
  "meta" : {
    "versionId" : "12",
    "lastUpdated" : "2025-03-16T09:43:10.014Z",
    "profile" : [
      🔗 "http://hl7.org/fhir/uv/ebm/StructureDefinition/net-effect-contribution"
    ]
  },
  "text" : {
    "status" : "empty",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>[No data.]</p></div>"
  },
  "extension" : [
    {
      "url" : "http://hl7.org/fhir/uv/ebm/StructureDefinition/cite-as",
      "valueMarkdown" : "NetEffectContribution: Remission of diabetes for Example for GIN 2022 [Database Entry: FHIR Evidence Resource]. Contributors: Brian S. Alper [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 179588. Revised 2025-03-05. Available at: https://fevir.net/resources/Evidence/179588. Computable resource at: https://fevir.net/resources/Evidence/179588#json."
    }
  ],
  "url" : "https://fevir.net/resources/Evidence/179588",
  "identifier" : [
    {
      "type" : {
        "coding" : [
          {
            "system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
            "code" : "ACSN",
            "display" : "Accession ID"
          }
        ],
        "text" : "FEvIR Object Identifier"
      },
      "system" : "urn:ietf:rfc:3986",
      "value" : "https://fevir.net/FOI/179588",
      "assigner" : {
        "display" : "Computable Publishing LLC"
      }
    }
  ],
  "name" : "NetEffectContribution_Remission_of_diabetes_for_Example_for_GIN_2022",
  "title" : "NetEffectContribution: Remission of diabetes for Example for GIN 2022",
  "status" : "active",
  "publisher" : "Computable Publishing LLC",
  "contact" : [
    {
      "telecom" : [
        {
          "system" : "email",
          "value" : "support@computablepublishing.com"
        }
      ]
    }
  ],
  "author" : [
    {
      "name" : "Brian S. Alper"
    }
  ],
  "useContext" : [
    {
      "code" : {
        "system" : "https://fevir.net/resources/CodeSystem/179423",
        "code" : "evidence-communication",
        "display" : "Evidence Communication"
      },
      "valueCodeableConcept" : {
        "coding" : [
          {
            "system" : "https://fevir.net/resources/CodeSystem/179423",
            "code" : "ComparativeEvidence",
            "display" : "ComparativeEvidence"
          }
        ]
      }
    },
    {
      "code" : {
        "system" : "https://fevir.net/resources/CodeSystem/179423",
        "code" : "evidence-communication",
        "display" : "Evidence Communication"
      },
      "valueCodeableConcept" : {
        "coding" : [
          {
            "system" : "https://fevir.net/resources/CodeSystem/179423",
            "code" : "NetEffectContribution",
            "display" : "NetEffectContribution"
          }
        ]
      }
    }
  ],
  "copyright" : "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "description" : "2.15 (1.33 to 3.26) - example showing statistic.extension:modelExpression",
  "variableDefinition" : [
    {
      "description" : "Cohort study with baseline data of exposures from November 2005 through July 2010 and follow-up data from 2006 until death or through December 2015 at a tertiary care outpatient center, Vestfold Hospital Trust, Norway. Consecutive treatment-seeking adult patients (n\u2009=\u20092109) with severe obesity assessed (221 patients excluded and 1888 patients included).",
      "variableRole" : "population",
      "observed" : {
        🔗 "reference" : "Group/178427",
        "type" : "Group",
        "display" : "StudyGroup: Severely Obese Adults 2018 Norwegian Cohort"
      }
    },
    {
      "description" : "comparison groups of bariatric surgery vs. no bariatric surgery",
      "variableRole" : "exposure",
      "comparatorCategory" : "no bariatric surgery",
      "observed" : {
        🔗 "reference" : "EvidenceVariable/172427",
        "type" : "EvidenceVariable",
        "display" : "GroupAssignment: Bariatric Surgery vs. no bariatric surgery"
      }
    },
    {
      "description" : "Remission of diabetes",
      "variableRole" : "outcome",
      "observed" : {
        🔗 "reference" : "EvidenceVariable/104117",
        "type" : "EvidenceVariable",
        "display" : "OutcomeVariable: Remission of diabetes"
      }
    },
    {
      "extension" : [
        {
          "url" : "http://hl7.org/fhir/uv/ebm/StructureDefinition/relative-outcome-importance",
          "valueReference" : {
            🔗 "reference" : "ArtifactAssessment/104193",
            "type" : "ArtifactAssessment",
            "display" : "Outcome Importance Rating 5% of Remission of diabetes"
          }
        }
      ],
      "description" : "Relative Importance Multiplier",
      "variableRole" : "covariate",
      "roleSubtype" : {
        "coding" : [
          {
            "system" : "https://fevir.net/resources/CodeSystem/179423",
            "code" : "importance-multiplier",
            "display" : "Relative importance multiplier"
          }
        ]
      },
      "observed" : {
        "display" : "Relative Importance Multiplier"
      }
    }
  ],
  "statistic" : [
    {
      "extension" : [
        {
          "url" : "http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-expression",
          "valueExpression" : {
            "description" : "risk difference (relative risk x control event rate) multiplied by relative importance multiplier (defined in OutcomeImportance Profile) -- expression is pseudocode to demonstrate the concept",
            "name" : "Net effect contribution analysis",
            "expression" : "Evidence[id='104121'].statistic[statisticType='Relative Risk'] * Evidence[id='104396'].statistic[statisticType='Proportion'] * ArtifactAssessment[id='104193'].content[type.text='Outcome Importance'].quantity"
          }
        }
      ],
      "description" : "risk difference 2.15 (95% CI 1.33 to 3.26)",
      "statisticType" : {
        "coding" : [
          {
            "system" : "https://fevir.net/sevco",
            "code" : "STATO:0000424",
            "display" : "risk difference"
          }
        ]
      },
      "quantity" : {
        "value" : 2.15
      },
      "attributeEstimate" : [
        {
          "description" : "95% CI 1.33 to 3.26",
          "type" : {
            "coding" : [
              {
                "system" : "https://fevir.net/sevco",
                "code" : "STATO:0000196",
                "display" : "confidence interval"
              }
            ]
          },
          "level" : 0.95,
          "range" : {
            "low" : {
              "value" : 1.33
            },
            "high" : {
              "value" : 3.26
            }
          }
        }
      ],
      "modelCharacteristic" : [
        {
          "code" : {
            "text" : "Net effect contribution analysis"
          }
        }
      ]
    }
  ]
}