Name	Flags	Card.	Type	Description & Constraints
SubstanceSpecification	Σ TU		DomainResource	The detailed description of a substance, typically at a level beyond what is used for prescribing Elements defined in Ancestors: id, meta, implicitRules, language, text, contained, extension, modifierExtension
identifier	Σ	0..1	Identifier	Identifier by which this substance is known
type	Σ	0..1	CodeableConcept	High level categorization, e.g. polymer or nucleic acid
status	Σ	0..1	CodeableConcept	Status of substance within the catalogue e.g. approved
domain	Σ	0..1	CodeableConcept	If the substance applies to only human or veterinary use
description	Σ	0..1	string	Textual description of the substance
source	Σ	0..*	Reference( DocumentReference)	Supporting literature
comment	Σ	0..1	string	Textual comment about this record of a substance
moiety	Σ	0..*	BackboneElement	Moiety, for structural modifications
role	Σ	0..1	CodeableConcept	Role that the moiety is playing
identifier	Σ	0..1	Identifier	Identifier by which this moiety substance is known
name	Σ	0..1	string	Textual name for this moiety substance
stereochemistry	Σ	0..1	CodeableConcept	Stereochemistry type
opticalActivity	Σ	0..1	CodeableConcept	Optical activity type
molecularFormula	Σ	0..1	string	Molecular formula
amount[x]	Σ	0..1		Quantitative value for this moiety
amountQuantity			Quantity
amountString			string
property	Σ	0..*	BackboneElement	General specifications for this substance, including how it is related to other substances
category	Σ	0..1	CodeableConcept	A category for this property, e.g. Physical, Chemical, Enzymatic
code	Σ	0..1	CodeableConcept	Property type e.g. viscosity, pH, isoelectric point
parameters	Σ	0..1	string	Parameters that were used in the measurement of a property (e.g. for viscosity: measured at 20C with a pH of 7.1)
definingSubstance[x]	Σ	0..1		A substance upon which a defining property depends (e.g. for solubility: in water, in alcohol)
definingSubstanceReference			Reference( SubstanceSpecification | Substance)
definingSubstanceCodeableConcept			CodeableConcept
amount[x]	Σ	0..1		Quantitative value for this property
amountQuantity			Quantity
amountString			string
referenceInformation	Σ	0..1	Reference( SubstanceReferenceInformation)	General information detailing this substance
structure	Σ	0..1	BackboneElement	Structural information
stereochemistry	Σ	0..1	CodeableConcept	Stereochemistry type
opticalActivity	Σ	0..1	CodeableConcept	Optical activity type
molecularFormula	Σ	0..1	string	Molecular formula
molecularFormulaByMoiety	Σ	0..1	string	Specified per moiety according to the Hill system, i.e. first C, then H, then alphabetical, each moiety separated by a dot
isotope	Σ	0..*	BackboneElement	Applicable for single substances that contain a radionuclide or a non-natural isotopic ratio
identifier	Σ	0..1	Identifier	Substance identifier for each non-natural or radioisotope
name	Σ	0..1	CodeableConcept	Substance name for each non-natural or radioisotope
substitution	Σ	0..1	CodeableConcept	The type of isotopic substitution present in a single substance
halfLife	Σ	0..1	Quantity	Half life - for a non-natural nuclide
molecularWeight	Σ	0..1	BackboneElement	The molecular weight or weight range (for proteins, polymers or nucleic acids)
method	Σ	0..1	CodeableConcept	The method by which the molecular weight was determined
type	Σ	0..1	CodeableConcept	Type of molecular weight such as exact, average (also known as. number average), weight average
amount	Σ	0..1	Quantity	Used to capture quantitative values for a variety of elements. If only limits are given, the arithmetic mean would be the average. If only a single definite value for a given element is given, it would be captured in this field
molecularWeight	Σ	0..1	see molecularWeight	The molecular weight or weight range (for proteins, polymers or nucleic acids)
source	Σ	0..*	Reference( DocumentReference)	Supporting literature
representation	Σ	0..*	BackboneElement	Molecular structural representation
type	Σ	0..1	CodeableConcept	The type of structure (e.g. Full, Partial, Representative)
representation	Σ	0..1	string	The structural representation as text string in a format e.g. InChI, SMILES, MOLFILE, CDX
attachment	Σ	0..1	Attachment	An attached file with the structural representation
code	Σ	0..*	BackboneElement	Codes associated with the substance
code	Σ	0..1	CodeableConcept	The specific code
status	Σ	0..1	CodeableConcept	Status of the code assignment
statusDate	Σ	0..1	dateTime	The date at which the code status is changed as part of the terminology maintenance
comment	Σ	0..1	string	Any comment can be provided in this field, if necessary
source	Σ	0..*	Reference( DocumentReference)	Supporting literature
name	Σ	0..*	BackboneElement	Names applicable to this substance
name	Σ	1..1	string	The actual name
type	Σ	0..1	CodeableConcept	Name type
status	Σ	0..1	CodeableConcept	The status of the name
preferred	Σ	0..1	boolean	If this is the preferred name for this substance
language	Σ	0..*	CodeableConcept	Language of the name
domain	Σ	0..*	CodeableConcept	The use context of this name for example if there is a different name a drug active ingredient as opposed to a food colour additive
jurisdiction	Σ	0..*	CodeableConcept	The jurisdiction where this name applies
synonym	Σ	0..*	see name	A synonym of this name
translation	Σ	0..*	see name	A translation for this name
official	Σ	0..*	BackboneElement	Details of the official nature of this name
authority	Σ	0..1	CodeableConcept	Which authority uses this official name
status	Σ	0..1	CodeableConcept	The status of the official name
date	Σ	0..1	dateTime	Date of official name change
source	Σ	0..*	Reference( DocumentReference)	Supporting literature
molecularWeight	Σ	0..*	see molecularWeight	The molecular weight or weight range (for proteins, polymers or nucleic acids)
relationship	Σ	0..*	BackboneElement	A link between this substance and another, with details of the relationship
substance[x]	Σ	0..1		A pointer to another substance, as a resource or just a representational code
substanceReference			Reference( SubstanceSpecification)
substanceCodeableConcept			CodeableConcept
relationship	Σ	0..1	CodeableConcept	For example "salt to parent", "active moiety", "starting material"
isDefining	Σ	0..1	boolean	For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible substance relationships
amount[x]	Σ	0..1		A numeric factor for the relationship, for instance to express that the salt of a substance has some percentage of the active substance in relation to some other
amountQuantity			Quantity
amountRange			Range
amountRatio			Ratio
amountString			string
amountRatioLowLimit	Σ	0..1	Ratio	For use when the numeric
amountType	Σ	0..1	CodeableConcept	An operator for the amount, for example "average", "approximately", "less than"
source	Σ	0..*	Reference( DocumentReference)	Supporting literature
nucleicAcid	Σ	0..1	Reference( SubstanceNucleicAcid)	Data items specific to nucleic acids
polymer	Σ	0..1	Reference( SubstancePolymer)	Data items specific to polymers
protein	Σ	0..1	Reference( SubstanceProtein)	Data items specific to proteins
sourceMaterial	Σ	0..1	Reference( SubstanceSourceMaterial)	Material or taxonomic/anatomical source for the substance
Documentation for this format