Risk of fatal ICH with alteplase for stroke (id = "example-stroke-alteplase-fatalICH")

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<Evidence xmlns="http://hl7.org/fhir">
  <id value="example-stroke-alteplase-fatalICH"/> 
  <text> 
    <status value="generated"/> 
    <div xmlns="http://www.w3.org/1999/xhtml">
      
      <p> 
        &quot;Risk of fatal ICH with alteplase for stroke&quot; is a univariate
         risk estimate.
      </p> 
  
    </div> 
  </text> 
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  <url value="http://hl7.org/fhir/Evidence/example-stroke-alteplase-fatalICH"/> 
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    <value value="urn:oid:2.16.840.1.113883.4.642.10.1"/> 
  </identifier> 
  <name value="RiskOfFatalICHWithAlteplaseForStroke"/> 
  <title value="Risk of fatal ICH with alteplase for stroke"/> 
  <status value="draft"/> 
  <publisher value="HL7 International / Clinical Decision Support"/> 
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  <relatedArtifact> 
    <type value="citation"/> 
    <label value="Emberson 2014"/> 
    <display value="Effect of treatment delay, age, and stroke severity on the effects of intravenous
     thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual
     patient data from randomised trials."/> 
    <citation value="Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, et al;Stroke Thrombolysis
     Trialists' Collaborative Group. Effect of treatment delay, age, and stroke severity
     on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke:
     a meta-analysis of individual patient data from randomised trials. Lancet 2014
     Nov 29;384(9958):1929-35 PMID 25106063"/> 
    <document> 
      <url value="https://doi.org/10.1016/S0140-6736(14)60584-5"/> 
    </document> 
  </relatedArtifact> 
  <description value="2.7% incidence of fatal intracranial hemorrhage within 7 days with alteplase in
   patients with acute ischemic stroke"/> 
  <variableDefinition> 
    <variableRole value="population"/> 
    <observed> 
      <reference value="Group/Emberson-2014-IPD-MA-Alteplase-Cohort"/> 
      <type value="Group"/> 
      <display value="Emberson 2014 IPD-MA Alteplase Cohort"/> 
    </observed> 
    <intended> 
      <reference value="Group/AcuteIschemicStrokeTreatedWithAlteplase"/> 
      <type value="Group"/> 
      <display value="adults with acute ischemic stroke treated with alteplase"/> 
    </intended> 
  </variableDefinition> 
  <variableDefinition> 
    <variableRole value="outcome"/> 
    <observed> 
      <reference value="EvidenceVariable/example-fatal-ICH-in-7-days"/> 
      <type value="EvidenceVariable"/> 
      <display value="fatal ICH"/> 
    </observed> 
    <intended> 
      <reference value="EvidenceVariable/example-fatal-ICH-in-7-days"/> 
      <type value="EvidenceVariable"/> 
      <display value="fatal ICH"/> 
    </intended> 
  </variableDefinition> 
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      <code value="IPD-MA"/> 
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  </synthesisType> 
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  </studyDesign> 
  <statistic> 
    <statisticType> 
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        <system value="http://terminology.hl7.org/CodeSystem/statistic-type"/> 
        <code value="C44256"/> 
        <display value="Proportion"/> 
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    </statisticType> 
    <quantity> 
      <value value="0.026835741669"/> 
    </quantity> 
    <numberOfEvents value="91"/> 
    <sampleSize> 
      <numberOfStudies value="9"/> 
      <numberOfParticipants value="3391"/> 
    </sampleSize> 
  </statistic> 
</Evidence>