This page is part of the FHIR Specification v6.0.0-ballot1: Release 6 Ballot (1st Draft) (see Ballot Notes). The current version is 5.0.0. For a full list of available versions, see the Directory of published versions
Clinical Decision Support Work Group | Maturity Level: N/A | Standards Status: Informative | Compartments: No defined compartments |
Raw JSON (canonical form + also see JSON Format Specification)
Effect of Alteplase vs No alteplase on mRS 3-6 at 90 days in Stroke 0-3 hours prior
{ "resourceType" : "Evidence", "id" : "example-stroke-0-3-alteplase-vs-no-alteplase-mRS3-6", "text" : { "status" : "generated", "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n \n <p>\n "Effect of Alteplase vs No alteplase on mRS 3-6 at 90 days in Stroke 0-3 hours prior" is a comparative effect estimate.\n </p>\n\t\n </div>" }, "extension" : [{ "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg", "valueCode" : "cds" }], "url" : "http://hl7.org/fhir/Evidence/example-stroke-0-3-alteplase-vs-no-alteplase-mRS3-6", "identifier" : [{ "system" : "urn:ietf:rfc:3986", "value" : "urn:oid:2.16.840.1.113883.4.642.10.5" }], "name" : "EffectOfAlteplaseVsNoAlteplaseOnMRS36At90DaysInStroke03HoursPrior", "title" : "Effect of Alteplase vs No alteplase on mRS 3-6 at 90 days in Stroke 0-3 hours prior", "status" : "draft", "publisher" : "HL7 International / Clinical Decision Support", "contact" : [{ "telecom" : [{ "system" : "url" }] }], "relatedArtifact" : [{ "type" : "citation", "label" : "Wardlaw 2014", "display" : "Analysis 1.16 from Wardlaw 2014", "citation" : "Wardlaw JM, Murray V, Berge E, del Zoppo GJ. Thrombolysis for acute ischaemic stroke. Cochrane Database Syst Rev. 2014 Jul 29(7):CD000213. PMID 25072528", "document" : { "url" : "https://doi.org/10.1002/14651858.CD000213.pub3" } }], "description" : "mRS 3-6 at 90 days Odds Ratio 0.65 for Alteplase vs. No Alteplase in patients with acute ischemic stroke 0-3 hours prior", "variableDefinition" : [{ "variableRole" : "population", "observed" : { "reference" : "EvidenceVariable/Wardlaw2014Analysis1.16.3EvidenceSet", "type" : "EvidenceVariable", "display" : "Wardlaw 2014 Analysis 1.16.3 Evidence set" }, "intended" : { "reference" : "Group/AcuteIschemicStroke0-3Hours", "type" : "Group", "display" : "stroke at 0-3 hours" } }, { "variableRole" : "outcome", "observed" : { "reference" : "EvidenceVariable/example-mRS3-6-at-90days", "type" : "EvidenceVariable", "display" : "mRS 3-6 at 90 days" }, "intended" : { "reference" : "EvidenceVariable/example-dead-or-dependent-90day", "type" : "EvidenceVariable", "display" : "Dead or functionally dependent at 90 days" } }, { "variableRole" : "exposure", "comparatorCategory" : "No Alteplase", "observed" : { "reference" : "EvidenceVariable/example-group-assignment-alteplase-for-stroke-vs-no-alteplase", "type" : "EvidenceVariable", "display" : "Group Assignment: Alteplase for Stroke vs No Alteplase" } }], "synthesisType" : { "coding" : [{ "system" : "http://terminology.hl7.org/CodeSystem/synthesis-type", "code" : "std-MA", "display" : "summary data meta-analysis" }] }, "studyDesign" : [{ "coding" : [{ "system" : "http://hl7.org/fhir/study-design", "code" : "SEVCO:01003", "display" : "randomized assignment" }] }], "statistic" : [{ "statisticType" : { "coding" : [{ "system" : "http://terminology.hl7.org/CodeSystem/statistic-type", "code" : "C16932", "display" : "Odds Ratio" }] }, "quantity" : { "value" : 0.65 }, "numberOfEvents" : 1137, "sampleSize" : { "numberOfStudies" : 6, "numberOfParticipants" : 1779 }, "attributeEstimate" : [{ "description" : "95% CI 0.54 to 0.80", "type" : { "coding" : [{ "system" : "http://terminology.hl7.org/CodeSystem/attribute-estimate-type", "code" : "C53324", "display" : "Confidence interval" }] }, "level" : 0.95, "range" : { "low" : { "value" : 0.54 }, "high" : { "value" : 0.8 } } }, { "description" : "P-value = 0.000023", "type" : { "coding" : [{ "system" : "http://terminology.hl7.org/CodeSystem/attribute-estimate-type", "code" : "C44185", "display" : "P-value" }] }, "quantity" : { "value" : 0.000023 } }, { "description" : "Heterogeneity I-sq = 0.0%", "type" : { "coding" : [{ "system" : "http://terminology.hl7.org/CodeSystem/attribute-estimate-type", "code" : "0000420", "display" : "I-squared" }] }, "quantity" : { "value" : 0, "unit" : "%", "system" : "http://unitsofmeasure.org", "code" : "%" } }] }], "certainty" : [{ "description" : "Moderate certainty due to risk of bias", "type" : { "coding" : [{ "system" : "http://hl7.org/fhir/certainty-type", "code" : "Overall", "display" : "Overall certainty" }] }, "rating" : { "coding" : [{ "system" : "http://hl7.org/fhir/certainty-rating", "code" : "moderate", "display" : "Moderate quality" }] }, "subcomponent" : [{ "type" : { "coding" : [{ "system" : "http://hl7.org/fhir/certainty-type", "code" : "PublicationBias", "display" : "Publication bias" }] }, "rating" : { "coding" : [{ "system" : "http://hl7.org/fhir/certainty-rating", "code" : "no-concern", "display" : "no serious concern" }] } }, { "type" : { "coding" : [{ "system" : "http://hl7.org/fhir/certainty-type", "code" : "Inconsistency", "display" : "Inconsistency" }] }, "rating" : { "coding" : [{ "system" : "http://hl7.org/fhir/certainty-rating", "code" : "no-concern", "display" : "no serious concern" }] } }, { "type" : { "coding" : [{ "system" : "http://hl7.org/fhir/certainty-type", "code" : "Imprecision", "display" : "Imprecision" }] }, "rating" : { "coding" : [{ "system" : "http://hl7.org/fhir/certainty-rating", "code" : "no-concern", "display" : "no serious concern" }] } }, { "type" : { "coding" : [{ "system" : "http://hl7.org/fhir/certainty-type", "code" : "Indirectness", "display" : "Indirectness" }] }, "rating" : { "coding" : [{ "system" : "http://hl7.org/fhir/certainty-rating", "code" : "no-concern", "display" : "no serious concern" }] } }, { "note" : [{ "text" : "results largely influenced by IST-3 trial which was unblinded and NINDS trial which had allocation concealment not stated and baseline imbalances" }], "type" : { "coding" : [{ "system" : "http://hl7.org/fhir/certainty-type", "code" : "RiskOfBias", "display" : "Risk of bias" }] }, "rating" : { "coding" : [{ "system" : "http://hl7.org/fhir/certainty-rating", "code" : "serious-concern", "display" : "serious concern" }] } }] }] }
Usage note: every effort has been made to ensure that the examples are correct and useful, but they are not a normative part of the specification.
FHIR ®© HL7.org 2011+. FHIR R6 hl7.fhir.core#6.0.0-ballot1 generated on Mon, Dec 18, 2023 15:17+1100.
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