Evidence-example-stroke-alteplase-fatalICH.json

Risk of fatal ICH with alteplase for stroke

{
  "resourceType": "Evidence",
  "id": "example-stroke-alteplase-fatalICH",
  "text": {
    "status": "generated",
    "div": "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n      <p>\n        &quot;Risk of fatal ICH with alteplase for stroke&quot; is a univariate risk estimate.\n      </p>\n\t</div>"
  },
  "url": "Evidence/example-stroke-alteplase-fatalICH",
  "title": "Risk of fatal ICH with alteplase for stroke",
  "status": "draft",
  "useContext": [
    {
      "code": {
        "system": "http://terminology.hl7.org/CodeSystem/usage-context-type",
        "code": "focus"
      },
      "valueCodeableConcept": {
        "text": "Stroke"
      }
    },
    {
      "code": {
        "system": "http://snomed.info/sct",
        "code": "1386000",
        "display": "Intracranial hemorrhage"
      },
      "valueRange": {
        "low": {
          "value": 0,
          "unit": "d"
        },
        "high": {
          "value": 7,
          "unit": "d"
        }
      }
    }
  ],
  "relatedArtifact": [
    {
      "type": "citation",
      "label": "Emberson 2014",
      "display": "Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials.",
      "citation": "Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, et al;Stroke Thrombolysis Trialists' Collaborative Group. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet 2014 Nov 29;384(9958):1929-35 PMID 25106063",
      "url": "https://doi.org/10.1016/S0140-6736(14)60584-5"
    }
  ],
  "description": "2.7% incidence of fatal intracranial hemorrhage within 7 days with alteplase in patients with acute ischemic stroke",
  "variableDefinition": [
    {
      "variableRole": {
        "coding": [
          {
            "system": "http://terminology.hl7.org/CodeSystem/variable-role",
            "code": "population",
            "display": "population"
          }
        ]
      },
      "observed": {
        "reference": "Group/AcuteIschemicStroke",
        "type": "Group",
        "display": "adults with acute ischemic stroke"
      },
      "intended": {
        "reference": "Group/AcuteIschemicStroke",
        "type": "Group",
        "display": "adults with acute ischemic stroke"
      }
    },
    {
      "variableRole": {
        "coding": [
          {
            "system": "http://terminology.hl7.org/CodeSystem/variable-role",
            "code": "population",
            "display": "population"
          }
        ]
      },
      "observed": {
        "reference": "Group/Emberson-2014-IPD-MA-Alteplase-Cohort",
        "type": "Group",
        "display": "Emberson 2014 IPD-MA Alteplase Cohort"
      },
      "intended": {
        "reference": "Group/AcuteIschemicStrokeTreatedWithAlteplase",
        "type": "Group",
        "display": "adults with acute ischemic stroke treated with alteplase"
      }
    },
    {
      "variableRole": {
        "coding": [
          {
            "system": "http://terminology.hl7.org/CodeSystem/variable-role",
            "code": "measuredVariable",
            "display": "measured variable"
          }
        ]
      },
      "observed": {
        "reference": "EvidenceVariable/example-fatal-ICH-in-7-days",
        "type": "EvidenceVariable",
        "display": "fatal ICH"
      },
      "intended": {
        "reference": "EvidenceVariable/example-fatal-ICH-in-7-days",
        "type": "EvidenceVariable",
        "display": "fatal ICH"
      }
    }
  ],
  "synthesisType": {
    "coding": [
      {
        "system": "http://terminology.hl7.org/CodeSystem/synthesis-type",
        "code": "IPD-MA",
        "display": "individual patient data meta-analysis"
      }
    ]
  },
  "studyType": {
    "coding": [
      {
        "system": "http://terminology.hl7.org/CodeSystem/study-type",
        "code": "RCT",
        "display": "randomized trial"
      }
    ]
  },
  "statistic": [
    {
      "statisticType": {
        "coding": [
          {
            "system": "http://terminology.hl7.org/CodeSystem/statistic-type",
            "code": "C44256",
            "display": "Proportion"
          }
        ]
      },
      "quantity": {
        "value": 0.026835741669
      },
      "numberOfEvents": 91,
      "sampleSize": {
        "numberOfStudies": 9,
        "numberOfParticipants": 3391
      }
    }
  ]
}