Evidence-example-mortalitylongterm-corticosteroids

Generated Narrative with Details

id: Evidence-Example-MortalityLongTerm-Corticosteroids

title: Corticosteroids for Patients with Sepsis with Mortality (60 days to 1 year)

status: draft

relatedArtifact:

description: Occurrence of Mortality with Corticosteroids for patients with sepsis

ReferentGroups

variableDefinition

description: Mortality Longer term (60 days to 1 year)

variableRole: measured variable (Details : {http://terminology.hl7.org/CodeSystem/variable-role code 'measuredVariable' = 'measured variable', given as 'measured variable'})

actualDefinition: many studies had shorter term outcomes

intendedDefinition: Mortality Longer term (Follow up: 60 days to 1 year)

directnessMatch: moderate (Details : {http://terminology.hl7.org/CodeSystem/directness code 'moderate' = 'Moderate quality match', given as 'moderate'})

variableDefinition

description: Corticosteroids

variableRole: exposure (Details : {http://terminology.hl7.org/CodeSystem/variable-role code 'exposure' = 'exposure', given as 'exposure'})

actualDefinition: ???

intendedDefinition: Corticosteroids

directnessMatch: ??? (Details : {http://terminology.hl7.org/CodeSystem/directness code 'null' = 'null', given as '???'})

synthesisType: summary data meta-analysis (Details : {http://terminology.hl7.org/CodeSystem/synthesis-type code 'std-MA' = 'summary data meta-analysis', given as 'summary data meta-analysis'})

studyType: randomized trial (Details : {http://terminology.hl7.org/CodeSystem/study-type code 'RCT' = 'randomized trial', given as 'randomized trial'})

statistic:

certainty

description: Low, due to serious imprecision and indirectness.

rating: Low quality (Details : {http://terminology.hl7.org/CodeSystem/certainty-rating code 'low' = 'Low quality', given as 'Low quality'})

certaintySubcomponent

note: Note that all studies that reported 90 day to 1 year mortality also reported 28-30 day mortality: the CI 95% around the pooled effect for short term mortality also excludes no effect: RR 0.91 (CI 95% 0.84 - 0.98).

type: Risk of bias (Details : {http://terminology.hl7.org/CodeSystem/certainty-subcomponent-type code 'RiskOfBias' = 'Risk of bias', given as 'Risk of bias'})

rating: no serious concern (Details : {http://terminology.hl7.org/CodeSystem/certainty-subcomponent-rating code 'no-concern' = 'no serious concern', given as 'no serious concern'})

certaintySubcomponent

type: Inconsistency (Details : {http://terminology.hl7.org/CodeSystem/certainty-subcomponent-type code 'Inconsistency' = 'Inconsistency', given as 'Inconsistency'})

rating: no serious concern (Details : {http://terminology.hl7.org/CodeSystem/certainty-subcomponent-rating code 'no-concern' = 'no serious concern', given as 'no serious concern'})

certaintySubcomponent

note: Only a small proportion of studies reported longer-term mortality.

type: Indirectness (Details : {http://terminology.hl7.org/CodeSystem/certainty-subcomponent-type code 'Indirectness' = 'Indirectness', given as 'Indirectness'})

rating: serious concern (Details : {http://terminology.hl7.org/CodeSystem/certainty-subcomponent-rating code 'serious-concern' = 'serious concern', given as 'serious concern'})

certaintySubcomponent

note: Confidence interval includes no effect.

type: Imprecision (Details : {http://terminology.hl7.org/CodeSystem/certainty-subcomponent-type code 'Imprecision' = 'Imprecision', given as 'Imprecision'})

rating: serious concern (Details : {http://terminology.hl7.org/CodeSystem/certainty-subcomponent-rating code 'serious-concern' = 'serious concern', given as 'serious concern'})

certaintySubcomponent

type: Publication bias (Details : {http://terminology.hl7.org/CodeSystem/certainty-subcomponent-type code 'PublicationBias' = 'Publication bias', given as 'Publication bias'})

rating: no serious concern (Details : {http://terminology.hl7.org/CodeSystem/certainty-subcomponent-rating code 'no-concern' = 'no serious concern', given as 'no serious concern'})