FHIR Release 3 (STU)
DiagnosticsThis page is part of the FHIR Specification (v3.0.2: STU 3). The current version which supercedes this version is 5.0.0. For a full list of available versions, see the Directory of published versions 
. Page versions: R4 R3
| Orders and Observations Work Group | Maturity Level: N/A | Ballot Status: Informative | Compartments: Device, Encounter, Patient, Practitioner |
An example of a HLA genotyping results report (id = "hla-1")
<Bundle xmlns="http://hl7.org/fhir"> <id value="hla-1"/> <type value="transaction"/> <entry> <fullUrl value="urn:uuid:b0a4b18e-94e7-4b1b-8031-c7ae4bdd8db9"/> <resource> <DiagnosticReport> <text> <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml"> <h3> HLA-A,-B,-C genotyping report for Mary Chalmers (MRN:12345)</h3> <pre> LOCUS ALLELE 1 ALLELE 2 HLA-A HLA-A:01:01G HLA-A*01:02 HLA-B HLA-B*15:01:01G HLA-B*57:01:01G HLA-C HLA-C*01:02:01G HLA-C*03:04:01G </pre> <p> Allele assignments based on IMGT/HLA 3.23</p> <p> Effective date: 2015-12-15</p> <p> Method: Sequencing of exons 2 and 3 of HLA Class I genes</p> <p> Lab: aTypingLab Inc</p> <p> Note: Please refer the <a href="genomics.html#hla">implementation guide </a> for more explanation on this carefully organized bundle example.</p> <pre> Bob Milius - NMDP - 2016-12-01 Transaction bundle that creates and links: + DiagnosticReport summarizing genotyping for HLA-A,-B,-C typing of patient(donor) + Obervations for each genotype + Observations for each allele + Sequences for exons 2 and 3 for HLA-A,-B, -C The endpoints of the following resources are hardcoded into this transaction bundle because these are presumed to already exist when developing the DiagnosticRequest which was to generate this report bundle: Patient/119 (potential donor) Specimen/120 (buccal swab) Organization/68 (typing lab) ProcedureRequest/123 (report is based on this request) </pre> </div> </text> <extension url="http://hl7.org/fhir/StructureDefinition/hla-genotyping-results-allele-database"> <valueCodeableConcept> <coding> <system value="http://www.ebi.ac.uk/ipd/imgt/hla/"/> <version value="3.23"/> </coding> <text value="IMGT/HLA 3.23"/> </valueCodeableConcept> </extension> <extension url="http://hl7.org/fhir/StructureDefinition/hla-genotyping-results-glstring"> <extension url="text"> <valueString value="HLA-A:01:01G+HLA-A*01:02^HLA-B*15:01:01:01+HLA-B*57:01:01^HLA-C*01:02:01+HLA-C*03:04:01:01"/> </extension> <extension url="uri"> <valueUri value="https://gl.nmdp.org/imgt-hla/3.23.0/multilocus-unphased-genotype/i"/> </extension> </extension> <extension url="http://hl7.org/fhir/StructureDefinition/hla-genotyping-results-method"> <valueCodeableConcept> <coding> <system value="http://www.ncbi.nlm.nih.gov/gtr/"/> <code value="GTR000000000.0"/> </coding> <text value="Next Generation Sequencing of exons 2 and 3 of HLA Class I genes"/> </valueCodeableConcept> </extension> <!-- Latest specification no longer contains DiagnosticRequest resources The SPEC uses ProcedureRequest instead to provide a record of a request for a diagnostic investigation. Although I only change the link here, there are lots of things that need to change in the original example of the original DiagnosticRequest (TODO) --> <basedOn> <reference value="ProcedureRequest/123"/> </basedOn> <status value="final"/> <category> <coding> <system value="http://hl7.org/fhir/v2/0074"/> <code value="GE"/> <display value="Genetics"/> </coding> </category> <code> <coding> <system value="http://loinc.org"/> <code value="13303-3"/> <display value="HLA-A+B+C (class I) [Type]"/> </coding> </code> <subject> <reference value="Patient/119"/> <display value="Mary Chalmers"/> </subject> <effectiveDateTime value="2016-12-15"/> <issued value="2016-12-15T14:15:30-06:00"/> <performer> <actor> <reference value="Organization/68"/> <display value="aTypingLab Inc"/> </actor> </performer> <specimen> <reference value="Specimen/67"/> <display value="buccal swab from Mary Chalmers"/> </specimen> <result> <reference value="urn:uuid:49a86246-4004-42eb-9bdc-f542f93f9228"/> <display value="HLA-A: HLA-A:01:01G+HLA-A*01:02"/> </result> <result> <reference value="urn:uuid:60613a43-c4cb-4502-b3e2-cf9215feaa70"/> <display value="HLA-B: HLA-B*15:01:01G+HLA-B*57:01:01G"/> </result> <result> <reference value="urn:uuid:0e0a780e-4486-4cd0-bfae-7243c579f208"/> <display value="HLA-C: HLA-C*01:02:01G+HLA-C*03:04:01G"/> </result> </DiagnosticReport> </resource> <!-- transaction details --> <request> <method value="POST"/> <url value="DiagnosticReport"/> </request> </entry> <entry> <fullUrl value="urn:uuid:8200dab6-18a2-4550-b913-a7db480c0804"/> <resource> <Sequence> <text> <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml"> <pre> "HLA-A*01:01:01:01, exon 2"</pre> </div> </text> <type value="dna"/> <coordinateSystem value="0"/> <patient> <reference value="Patient/119"/> <display value="Mary Chalmers"/> </patient> <specimen> <reference value="Specimen/120"/> <display value="buccal swab from Mary Chalmers"/> </specimen> <referenceSeq> <referenceSeqId> <coding> <system value="http://www.ebi.ac.uk/ipd/imgt/hla/"/> <version value="3.23"/> <code value="HLA00001"/> </coding> <text value="HLA-A*01:01:01:01"/> </referenceSeqId> <windowStart value="503"/> <windowEnd value="773"/> </referenceSeq> <observedSeq value="GCTCCCACTCCATGAGGTATTTCTTCACATCCGTGTCCCGGCCCGGCCGCGGGGAGCCCCGCTTCATCGCCGTGGGCTACGTGGACGACACGCAGTTCGT GCGGTTCGACAGCGACGCCGCGAGCCAGAAGATGGAGCCGCGGGCGCCGTGGATAGAGCAGGAGGGGCCGGAGTATTGGGACCAGGAGACACGGAATATGA AGGCCCACTCACAGACTGACCGAGCGAACCTGGGGACCCTGCGCGGCTACTACAACCAGAGCGAGGACG"/> </Sequence> </resource> <!-- transaction details --> <request> <method value="POST"/> <url value="Sequence"/> </request> </entry> <entry> <fullUrl value="urn:uuid:7c393185-f15c-45bc-a714-c0fdbea32675"/> <resource> <Sequence> <text> <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml"> <pre> "HLA-A*01:01:01:01, exon 3"</pre> </div> </text> <type value="dna"/> <coordinateSystem value="0"/> <patient> <reference value="Patient/119"/> <display value="Mary Chalmers"/> </patient> <specimen> <reference value="Specimen/120"/> <display value="buccal swab from Mary Chalmers"/> </specimen> <referenceSeq> <referenceSeqId> <coding> <system value="http://www.ebi.ac.uk/ipd/imgt/hla/"/> <version value="3.23"/> <code value="HLA00001"/> </coding> <text value="HLA-A*01:01:01:01"/> </referenceSeqId> <windowStart value="1014"/> <windowEnd value="1290"/> </referenceSeq> <observedSeq value="GTTCTCACACCATCCAGATAATGTATGGCTGCGACGTGGGGCCGGACGGGCGCTTCCTCCGCGGGTACCGGCAGGACGCCTACGACGGCAAGGATTACAT CGCCCTGAACGAGGACCTGCGCTCTTGGACCGCGGCGGACATGGCAGCTCAGATCACCAAGCGCAAGTGGGAGGCGGTCCATGCGGCGGAGCAGCGGAGAG TCTACCTGGAGGGCCGGTGCGTGGACGGGCTCCGCAGATACCTGGAGAACGGGAAGGAGACGCTGCAGCGCACGG"/> </Sequence> </resource> <!-- transaction details --> <request> <method value="POST"/> <url value="Sequence"/> </request> </entry> <entry> <fullUrl value="urn:uuid:65c85f14-c3a0-4b72-818f-820e04fcc621"/> <resource> <Sequence> <text> <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml"> <pre> "HLA-A*01:02, exon 2"</pre> </div> </text> <type value="dna"/> <coordinateSystem value="0"/> <patient> <reference value="Patient/119"/> <display value="Mary Chalmers"/> </patient> <specimen> <reference value="Specimen/120"/> <display value="buccal swab from Mary Chalmers"/> </specimen> <referenceSeq> <referenceSeqId> <coding> <system value="http://www.ebi.ac.uk/ipd/imgt/hla/"/> <version value="3.23"/> <code value="HLA00002"/> </coding> <text value="HLA-A*01:02"/> </referenceSeqId> <windowStart value="503"/> <windowEnd value="773"/> </referenceSeq> <observedSeq value="GCTCCCACTCCATGAGGTATTTCTCCACATCCGTGTCCCGGCCCGGCAGTGGAGAGCCCCGCTTCATCGCAGTGGGCTACGTGGACGACACGCAGTTCGT GCGGTTCGACAGCGACGCCGCGAGCCAGAAGATGGAGCCGCGGGCGCCGTGGATAGAGCAGGAGGGGCCGGAGTATTGGGACCAGGAGACACGGAATATGA AGGCCCACTCACAGACTGACCGAGCGAACCTGGGGACCCTGCGCGGCTACTACAACCAGAGCGAGGACG"/> </Sequence> </resource> <!-- transaction details --> <request> <method value="POST"/> <url value="Sequence"/> </request> </entry> <entry> <fullUrl value="urn:uuid:fbba9fe7-0ece-4ec1-9233-a437a8d242a0"/> <resource> <Sequence> <text> <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml"> <pre> "HLA-A*01:02, exon 3"</pre> </div> </text> <type value="dna"/> <coordinateSystem value="0"/> <patient> <reference value="Patient/119"/> <display value="Mary Chalmers"/> </patient> <specimen> <reference value="Specimen/120"/> <display value="buccal swab from Mary Chalmers"/> </specimen> <referenceSeq> <referenceSeqId> <coding> <system value="http://www.ebi.ac.uk/ipd/imgt/hla/"/> <version value="3.23"/> <code value="HLA00002"/> </coding> <text value="HLA-A*01:02"/> </referenceSeqId> <windowStart value="1014"/> <windowEnd value="1290"/> </referenceSeq> <observedSeq value="GTTCTCACACCATCCAGATAATGTATGGCTGCGACGTGGGGCCGGACGGGCGCTTCCTCCGCGGGTACCGGCAGGACGCCTACGACGGCAAGGATTACAT CGCCCTGAACGAGGACCTGCGCTCTTGGACCGCGGCGGACATGGCAGCTCAGATCACCAAGCGCAAGTGGGAGGCGGTCCATGCGGCGGAGCAGCGGAGAG TCTACCTGGAGGGCCGGTGCGTGGACGGGCTCCGCAGATACCTGGAGAACGGGAAGGAGACGCTGCAGCGCACGG"/> </Sequence> </resource> <!-- transaction details --> <request> <method value="POST"/> <url value="Sequence"/> </request> </entry> <entry> <fullUrl value="urn:uuid:cbabf93e-1b4b-46f2-ba1e-d84862670670"/> <resource> <Sequence> <text> <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml"> <pre> "HLA-B*15:01:01:01, exon 2"</pre> </div> </text> <type value="dna"/> <coordinateSystem value="0"/> <patient> <reference value="Patient/119"/> <display value="Mary Chalmers"/> </patient> <specimen> <reference value="Specimen/120"/> <display value="buccal swab from Mary Chalmers"/> </specimen> <referenceSeq> <referenceSeqId> <coding> <system value="http://www.ebi.ac.uk/ipd/imgt/hla/"/> <version value="3.23"/> <code value="HLA00162"/> </coding> <text value="HLA-B*15:01:01:01"/> </referenceSeqId> <windowStart value="486"/> <windowEnd value="756"/> </referenceSeq> <observedSeq value="GCTCCCACTCCATGAGGTATTTCTACACCGCCATGTCCCGGCCCGGCCGCGGGGAGCCCCGCTTCATCGCAGTGGGCTACGTGGACGACACCCAGTTCGT GAGGTTCGACAGCGACGCCGCGAGTCCGAGGATGGCGCCCCGGGCGCCATGGATAGAGCAGGAGGGGCCGGAGTATTGGGACCGGGAGACACAGATCTCCA AGACCAACACACAGACTTACCGAGAGAGCCTGCGGAACCTGCGCGGCTACTACAACCAGAGCGAGGCCG"/> </Sequence> </resource> <!-- transaction details --> <request> <method value="POST"/> <url value="Sequence"/> </request> </entry> <entry> <fullUrl value="urn:uuid:c233ad3d-1572-48d6-93da-0a583535e138"/> <resource> <Sequence> <text> <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml"> <pre> "HLA-B*15:01:01:01, exon 3"</pre> </div> </text> <type value="dna"/> <coordinateSystem value="0"/> <patient> <reference value="Patient/119"/> <display value="Mary Chalmers"/> </patient> <specimen> <reference value="Specimen/120"/> <display value="buccal swab from Mary Chalmers"/> </specimen> <referenceSeq> <referenceSeqId> <coding> <system value="http://www.ebi.ac.uk/ipd/imgt/hla/"/> <version value="3.23"/> <code value="HLA00162"/> </coding> <text value="HLA-B*15:01:01:01"/> </referenceSeqId> <windowStart value="1001"/> <windowEnd value="1277"/> </referenceSeq> <observedSeq value="GGTCTCACACCCTCCAGAGGATGTACGGCTGCGACGTGGGGCCGGACGGGCGCCTCCTCCGCGGGCATGACCAGTCCGCCTACGACGGCAAGGATTACAT CGCCCTGAACGAGGACCTGAGCTCCTGGACCGCGGCGGACACGGCGGCTCAGATCACCCAGCGCAAGTGGGAGGCGGCCCGTGAGGCGGAGCAGTGGAGAG CCTACCTGGAGGGCCTGTGCGTGGAGTGGCTCCGCAGATACCTGGAGAACGGGAAGGAGACGCTGCAGCGCGCGG"/> </Sequence> </resource> <!-- transaction details --> <request> <method value="POST"/> <url value="Sequence"/> </request> </entry> <entry> <fullUrl value="urn:uuid:05fa52d7-5c67-460a-8722-d3460b24d6fe"/> <resource> <Sequence> <text> <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml"> <pre> "HLA-B*57:01:01, exon 2"</pre> </div> </text> <type value="dna"/> <coordinateSystem value="0"/> <patient> <reference value="Patient/119"/> <display value="Mary Chalmers"/> </patient> <specimen> <reference value="Specimen/120"/> <display value="buccal swab from Mary Chalmers"/> </specimen> <referenceSeq> <referenceSeqId> <coding> <system value="http://www.ebi.ac.uk/ipd/imgt/hla/"/> <version value="3.23"/> <code value="HLA00381"/> </coding> <text value="HLA-B*57:01:01"/> </referenceSeqId> <windowStart value="485"/> <windowEnd value="755"/> </referenceSeq> <observedSeq value="GCTCCCACTCCATGAGGTATTTCTACACCGCCATGTCCCGGCCCGGCCGCGGGGAGCCCCGCTTCATCGCAGTGGGCTACGTGGACGACACCCAGTTCGT GAGGTTCGACAGCGACGCCGCGAGTCCGAGGATGGCGCCCCGGGCGCCATGGATAGAGCAGGAGGGGCCGGAGTATTGGGACGGGGAGACACGGAACATGA AGGCCTCCGCGCAGACTTACCGAGAGAACCTGCGGATCGCGCTCCGCTACTACAACCAGAGCGAGGCCG"/> </Sequence> </resource> <!-- transaction details --> <request> <method value="POST"/> <url value="Sequence"/> </request> </entry> <entry> <fullUrl value="urn:uuid:db69e549-6267-4777-b4b9-8813f3329309"/> <resource> <Sequence> <text> <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml"> <pre> "HLA-B*57:01:01, exon 3"</pre> </div> </text> <type value="dna"/> <coordinateSystem value="0"/> <patient> <reference value="Patient/119"/> <display value="Mary Chalmers"/> </patient> <specimen> <reference value="Specimen/120"/> <display value="buccal swab from Mary Chalmers"/> </specimen> <referenceSeq> <referenceSeqId> <coding> <system value="http://www.ebi.ac.uk/ipd/imgt/hla/"/> <version value="3.23"/> <code value="HLA00381"/> </coding> <text value="HLA-B*57:01:01"/> </referenceSeqId> <windowStart value="1001"/> <windowEnd value="1277"/> </referenceSeq> <observedSeq value="GGTCTCACATCATCCAGGTGATGTATGGCTGCGACGTGGGGCCGGACGGGCGCCTCCTCCGCGGGCATGACCAGTCCGCCTACGACGGCAAGGATTACAT CGCCCTGAACGAGGACCTGAGCTCCTGGACCGCGGCGGACACGGCGGCTCAGATCACCCAGCGCAAGTGGGAGGCGGCCCGTGTGGCGGAGCAGCTGAGAG CCTACCTGGAGGGCCTGTGCGTGGAGTGGCTCCGCAGATACCTGGAGAACGGGAAGGAGACGCTGCAGCGCGCGG"/> </Sequence> </resource> <!-- transaction details --> <request> <method value="POST"/> <url value="Sequence"/> </request> </entry> <entry> <fullUrl value="urn:uuid:bb55c2bc-5ad2-4bc1-8ff3-c407d06b12d0"/> <resource> <Sequence> <text> <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml"> <pre> "HLA-C*01:02:01, exon 2"</pre> </div> </text> <type value="dna"/> <coordinateSystem value="0"/> <patient> <reference value="Patient/119"/> <display value="Mary Chalmers"/> </patient> <specimen> <reference value="Specimen/120"/> <display value="buccal swab from Mary Chalmers"/> </specimen> <referenceSeq> <referenceSeqId> <coding> <system value="http://www.ebi.ac.uk/ipd/imgt/hla/"/> <version value="3.23"/> <code value="HLA00401"/> </coding> <text value="HLA-C*01:02:01"/> </referenceSeqId> <windowStart value="486"/> <windowEnd value="756"/> </referenceSeq> <observedSeq value="GCTCCCACTCCATGAAGTATTTCTTCACATCCGTGTCCCGGCCTGGCCGCGGAGAGCCCCGCTTCATCTCAGTGGGCTACGTGGACGACACGCAGTTCGT GCGGTTCGACAGCGACGCCGCGAGTCCGAGAGGGGAGCCGCGGGCGCCGTGGGTGGAGCAGGAGGGGCCGGAGTATTGGGACCGGGAGACACAGAAGTACA AGCGCCAGGCACAGACTGACCGAGTGAGCCTGCGGAACCTGCGCGGCTACTACAACCAGAGCGAGGCCG"/> </Sequence> </resource> <!-- transaction details --> <request> <method value="POST"/> <url value="Sequence"/> </request> </entry> <entry> <fullUrl value="urn:uuid:46938bb2-0486-4e87-bfd3-89aab2d5e22f"/> <resource> <Sequence> <text> <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml"> <pre> "HLA-C*01:02:01, exon 3"</pre> </div> </text> <type value="dna"/> <coordinateSystem value="0"/> <patient> <reference value="Patient/119"/> <display value="Mary Chalmers"/> </patient> <specimen> <reference value="Specimen/120"/> <display value="buccal swab from Mary Chalmers"/> </specimen> <referenceSeq> <referenceSeqId> <coding> <system value="http://www.ebi.ac.uk/ipd/imgt/hla/"/> <version value="3.23"/> <code value="HLA00401"/> </coding> <text value="HLA-C*01:02:01"/> </referenceSeqId> <windowStart value="1002"/> <windowEnd value="1278"/> </referenceSeq> <observedSeq value="GGTCTCACACCCTCCAGTGGATGTGTGGCTGCGACCTGGGGCCCGACGGGCGCCTCCTCCGCGGGTATGACCAGTACGCCTACGACGGCAAGGATTACAT CGCCCTGAACGAGGACCTGCGCTCCTGGACCGCCGCGGACACCGCGGCTCAGATCACCCAGCGCAAGTGGGAGGCGGCCCGTGAGGCGGAGCAGCGGAGAG CCTACCTGGAGGGCACGTGCGTGGAGTGGCTCCGCAGATACCTGGAGAACGGGAAGGAGACGCTGCAGCGCGCGG"/> </Sequence> </resource> <!-- transaction details --> <request> <method value="POST"/> <url value="Sequence"/> </request> </entry> <entry> <fullUrl value="urn:uuid:2ae2ff34-279e-43c2-9018-b054fd3fc1ce"/> <resource> <Sequence> <text> <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml"> <pre> "HLA-C*03:04:01:01, exon 2"</pre> </div> </text> <type value="dna"/> <coordinateSystem value="0"/> <patient> <reference value="Patient/119"/> <display value="Mary Chalmers"/> </patient> <specimen> <reference value="Specimen/120"/> <display value="buccal swab from Mary Chalmers"/> </specimen> <referenceSeq> <referenceSeqId> <coding> <system value="http://www.ebi.ac.uk/ipd/imgt/hla/"/> <version value="3.23"/> <code value="HLA00413"/> </coding> <text value="HLA-C*03:04:01:01"/> </referenceSeqId> <windowStart value="486"/> <windowEnd value="756"/> </referenceSeq> <observedSeq value="GCTCCCACTCCATGAGGTATTTCTACACCGCTGTGTCCCGGCCCGGCCGCGGGGAGCCCCACTTCATCGCAGTGGGCTACGTGGACGACACGCAGTTCGT GCGGTTCGACAGCGACGCCGCGAGTCCGAGAGGGGAGCCGCGGGCGCCGTGGGTGGAGCAGGAGGGGCCGGAGTATTGGGACCGGGAGACACAGAAGTACA AGCGCCAGGCACAGACTGACCGAGTGAGCCTGCGGAACCTGCGCGGCTACTACAACCAGAGCGAGGCCG"/> </Sequence> </resource> <!-- transaction details --> <request> <method value="POST"/> <url value="Sequence"/> </request> </entry> <entry> <fullUrl value="urn:uuid:19153ef1-68c6-47a2-9676-c4eefbd39af9"/> <resource> <Sequence> <text> <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml"> <pre> "HLA-C*03:04:01:01, exon 3"</pre> </div> </text> <type value="dna"/> <coordinateSystem value="0"/> <patient> <reference value="Patient/119"/> <display value="Mary Chalmers"/> </patient> <specimen> <reference value="Specimen/120"/> <display value="buccal swab from Mary Chalmers"/> </specimen> <referenceSeq> <referenceSeqId> <coding> <system value="http://www.ebi.ac.uk/ipd/imgt/hla/"/> <version value="3.23"/> <code value="HLA00413"/> </coding> <text value="HLA-C*03:04:01:01"/> </referenceSeqId> <windowStart value="1001"/> <windowEnd value="1277"/> </referenceSeq> <observedSeq value="GGTCTCACATCATCCAGAGGATGTATGGCTGCGACGTGGGGCCCGACGGGCGCCTCCTCCGCGGGTATGACCAGTACGCCTACGACGGCAAGGATTACAT CGCCCTGAACGAGGATCTGCGCTCCTGGACCGCCGCGGACACGGCGGCTCAGATCACCCAGCGCAAGTGGGAGGCGGCCCGTGAGGCGGAGCAGCTGAGAG CCTACCTGGAGGGCCTGTGCGTGGAGTGGCTCCGCAGATACCTGAAGAATGGGAAGGAGACGCTGCAGCGCGCGG"/> </Sequence> </resource> <!-- transaction details --> <request> <method value="POST"/> <url value="Sequence"/> </request> </entry> <entry> <fullUrl value="urn:uuid:b7765bbf-df40-486a-9f2f-404309643de6"/> <resource> <Observation> <text> <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml"><pre> HLA-A:01:01:01G</pre> </div> </text> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsGene"> <valueCodeableConcept> <coding> <system value="http://www.genenames.org"/> <code value="HGNC:4931"/> <display value="HLA-A"/> </coding> </valueCodeableConcept> </extension> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsAlleleName"> <valueCodeableConcept> <coding> <system value="http://www.ebi.ac.uk/cgi-bin/ipd/imgt/hla/"/> <code value="A*01:01:01:01"/> <display value="HLA-A*01:01:01G"/> </coding> </valueCodeableConcept> </extension> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsGenomicSourceClass"> <valueCodeableConcept> <coding> <system value="http://loinc.org"/> <code value="LA6683-2"/> <display value="germline"/> </coding> </valueCodeableConcept> </extension> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsPhaseSet"> <valueUri value="urn:uuid:e13f147e-41e5-4f7a-b20a-1b52b236c5ba"/> </extension> <status value="final"/> <code> <coding> <system value="http://loinc.org"/> <code value="57290-9"/> <display value="HLA-A [Type] by High resolution"/> </coding> </code> <subject> <reference value="Patient/119"/> <display value="Mary Chalmers"/> </subject> <effectiveDateTime value="2016-12-15"/> <specimen> <reference value="Specimen/120"/> <display value="buccal swab from Mary Chalmers"/> </specimen> <related> <type value="derived-from"/> <target> <reference value="urn:uuid:8200dab6-18a2-4550-b913-a7db480c0804"/> <display value="HLA-A*01:01:01:01, exon 2"/> </target> </related> <related> <type value="derived-from"/> <target> <reference value="urn:uuid:7c393185-f15c-45bc-a714-c0fdbea32675"/> <display value="HLA-A*01:01:01:01, exon 3"/> </target> </related> </Observation> </resource> <!-- transaction details --> <request> <method value="POST"/> <url value="Observation"/> </request> </entry> <entry> <fullUrl value="urn:uuid:d98d92a7-0e86-4ae5-b036-b7e1bba6ec32"/> <resource> <Observation> <text> <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml"><pre> HLA-A*01:02</pre> </div> </text> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsGene"> <valueCodeableConcept> <coding> <system value="http://www.genenames.org"/> <code value="HGNC:4931"/> <display value="HLA-A"/> </coding> </valueCodeableConcept> </extension> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsAlleleName"> <valueCodeableConcept> <coding> <system value="http://www.ebi.ac.uk/cgi-bin/ipd/imgt/hla/"/> <code value="A*01:02"/> <display value="HLA-A*01:02"/> </coding> </valueCodeableConcept> </extension> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsGenomicSourceClass"> <valueCodeableConcept> <coding> <system value="http://loinc.org"/> <code value="LA6683-2"/> <display value="germline"/> </coding> </valueCodeableConcept> </extension> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsPhaseSet"> <valueUri value="urn:uuid:af8e79ec-343e-4380-ba65-cec5266dc2d5"/> </extension> <status value="final"/> <code> <coding> <system value="http://loinc.org"/> <code value="57290-9"/> <display value="HLA-A [Type] by High resolution"/> </coding> </code> <subject> <reference value="Patient/119"/> <display value="Mary Chalmers"/> </subject> <effectiveDateTime value="2016-12-15"/> <specimen> <reference value="Specimen/120"/> <display value="buccal swab from Mary Chalmers"/> </specimen> <related> <type value="derived-from"/> <target> <reference value="urn:uuid:65c85f14-c3a0-4b72-818f-820e04fcc621"/> <display value="HLA-A*01:02, exon 2"/> </target> </related> <related> <type value="derived-from"/> <target> <reference value="urn:uuid:fbba9fe7-0ece-4ec1-9233-a437a8d242a0"/> <display value="HLA-A*01:02, exon 3"/> </target> </related> </Observation> </resource> <!-- transaction details --> <request> <method value="POST"/> <url value="Observation"/> </request> </entry> <entry> <fullUrl value="urn:uuid:49a86246-4004-42eb-9bdc-f542f93f9228"/> <resource> <Observation> <text> <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml"><pre> HLA-A:01:01G+HLA-A*01:02</pre> </div> </text> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsGene"> <valueCodeableConcept> <coding> <system value="http://www.genenames.org"/> <code value="HGNC:4931"/> <display value="HLA-A"/> </coding> </valueCodeableConcept> </extension> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsGenomicSourceClass"> <valueCodeableConcept> <coding> <system value="http://loinc.org"/> <code value="LA6683-2"/> <display value="germline"/> </coding> </valueCodeableConcept> </extension> <status value="final"/> <code> <coding> <system value="http://loinc.org"/> <code value="57290-9"/> <display value="HLA-A [Type] by High resolution"/> </coding> </code> <subject> <reference value="Patient/119"/> <display value="Mary Chalmers"/> </subject> <effectiveDateTime value="2016-12-15"/> <specimen> <reference value="Specimen/120"/> <display value="buccal swab from Mary Chalmers"/> </specimen> <related> <type value="derived-from"/> <target> <reference value="urn:uuid:b7765bbf-df40-486a-9f2f-404309643de6"/> <display value="HLA-A*01:01:01G, exons 2 and 3"/> </target> </related> <related> <type value="derived-from"/> <target> <reference value="urn:uuid:d98d92a7-0e86-4ae5-b036-b7e1bba6ec32"/> <display value="HLA-A*01:02, exons 2 and 3"/> </target> </related> </Observation> </resource> <!-- transaction details --> <request> <method value="POST"/> <url value="Observation"/> </request> </entry> <entry> <fullUrl value="urn:uuid:e2092243-2970-49d2-a90f-b90d1d49715a"/> <resource> <Observation> <text> <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml"><pre> HLA-B*15:01:01G</pre> </div> </text> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsGene"> <valueCodeableConcept> <coding> <system value="http://www.genenames.org"/> <code value="HGNC:4932"/> <display value="HLA-B"/> </coding> </valueCodeableConcept> </extension> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsAlleleName"> <valueCodeableConcept> <coding> <system value="http://www.ebi.ac.uk/cgi-bin/ipd/imgt/hla/"/> <code value="B*15:01:01:01"/> <display value="HLA-B*15:01:01G"/> </coding> </valueCodeableConcept> </extension> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsGenomicSourceClass"> <valueCodeableConcept> <coding> <system value="http://loinc.org"/> <code value="LA6683-2"/> <display value="germline"/> </coding> </valueCodeableConcept> </extension> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsPhaseSet"> <valueUri value="urn:uuid:29c67a1b-aeaa-4599-ae20-04b947ef73d8"/> </extension> <status value="final"/> <code> <coding> <system value="http://loinc.org"/> <code value="57291-7"/> <display value="HLA-B [Type] by High resolution"/> </coding> </code> <subject> <reference value="Patient/119"/> <display value="Mary Chalmers"/> </subject> <effectiveDateTime value="2016-12-15"/> <specimen> <reference value="Specimen/120"/> <display value="buccal swab from Mary Chalmers"/> </specimen> <related> <type value="derived-from"/> <target> <reference value="urn:uuid:cbabf93e-1b4b-46f2-ba1e-d84862670670"/> <display value="HLA-B*15:01:01:01, exon 2"/> </target> </related> <related> <type value="derived-from"/> <target> <reference value="urn:uuid:c233ad3d-1572-48d6-93da-0a583535e138"/> <display value="HLA-B*15:01:01:01, exon 3"/> </target> </related> </Observation> </resource> <!-- transaction details --> <request> <method value="POST"/> <url value="Observation"/> </request> </entry> <entry> <fullUrl value="urn:uuid:792be53e-d4fb-4887-a367-815ef6c706e5"/> <resource> <Observation> <text> <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml"><pre> HLA-B*57:01:01G</pre> </div> </text> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsGene"> <valueCodeableConcept> <coding> <system value="http://www.genenames.org"/> <code value="HGNC:4932"/> <display value="HLA-B"/> </coding> </valueCodeableConcept> </extension> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsAlleleName"> <valueCodeableConcept> <coding> <system value="http://www.ebi.ac.uk/cgi-bin/ipd/imgt/hla/"/> <code value="B*57:01:01"/> <display value="HLA-B*57:01:01G"/> </coding> </valueCodeableConcept> </extension> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsGenomicSourceClass"> <valueCodeableConcept> <coding> <system value="http://loinc.org"/> <code value="LA6683-2"/> <display value="germline"/> </coding> </valueCodeableConcept> </extension> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsPhaseSet"> <valueUri value="urn:uuid:a19a3557-b36c-4b35-ab8b-4783022066b9"/> </extension> <status value="final"/> <code> <coding> <system value="http://loinc.org"/> <code value="57291-7"/> <display value="HLA-B [Type] by High resolution"/> </coding> </code> <subject> <reference value="Patient/119"/> <display value="Mary Chalmers"/> </subject> <effectiveDateTime value="2016-12-15"/> <specimen> <reference value="Specimen/120"/> <display value="buccal swab from Mary Chalmers"/> </specimen> <related> <type value="derived-from"/> <target> <reference value="urn:uuid:05fa52d7-5c67-460a-8722-d3460b24d6fe"/> <display value="HLA-B*57:01:01, exon 2"/> </target> </related> <related> <type value="derived-from"/> <target> <reference value="urn:uuid:db69e549-6267-4777-b4b9-8813f3329309"/> <display value="HLA-B*57:01:01, exon 3"/> </target> </related> </Observation> </resource> <!-- transaction details --> <request> <method value="POST"/> <url value="Observation"/> </request> </entry> <entry> <fullUrl value="urn:uuid:60613a43-c4cb-4502-b3e2-cf9215feaa70"/> <resource> <Observation> <text> <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml"><pre> HLA-B*15:01:01G+HLA-B*57:01:01G</pre> </div> </text> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsGene"> <valueCodeableConcept> <coding> <system value="http://www.genenames.org"/> <code value="HGNC:4932"/> <display value="HLA-B"/> </coding> </valueCodeableConcept> </extension> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsGenomicSourceClass"> <valueCodeableConcept> <coding> <system value="http://loinc.org"/> <code value="LA6683-2"/> <display value="germline"/> </coding> </valueCodeableConcept> </extension> <status value="final"/> <code> <coding> <system value="http://loinc.org"/> <code value="57291-7"/> <display value="HLA-B [Type] by High resolution"/> </coding> </code> <subject> <reference value="Patient/119"/> <display value="Mary Chalmers"/> </subject> <effectiveDateTime value="2016-12-15"/> <specimen> <reference value="Specimen/120"/> <display value="buccal swab from Mary Chalmers"/> </specimen> <related> <type value="derived-from"/> <target> <reference value="urn:uuid:e2092243-2970-49d2-a90f-b90d1d49715a"/> <display value="HLA-B*15:01:01G, exons 2 and 3"/> </target> </related> <related> <type value="derived-from"/> <target> <reference value="urn:uuid:792be53e-d4fb-4887-a367-815ef6c706e5"/> <display value="HLA-B*57:01:01G, exons 2 and 3"/> </target> </related> </Observation> </resource> <!-- transaction details --> <request> <method value="POST"/> <url value="Observation"/> </request> </entry> <entry> <fullUrl value="urn:uuid:709c5315-9403-4867-9d82-0b953836665f"/> <resource> <Observation> <text> <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml"><pre> HLA-C*01:02:01</pre> </div> </text> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsGene"> <valueCodeableConcept> <coding> <system value="http://www.genenames.org"/> <code value="HGNC:4933"/> <display value="HLA-C"/> </coding> </valueCodeableConcept> </extension> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsAlleleName"> <valueCodeableConcept> <coding> <system value="http://www.ebi.ac.uk/cgi-bin/ipd/imgt/hla/"/> <code value="C*01:02:01"/> <display value="HLA-C*01:02:01"/> </coding> </valueCodeableConcept> </extension> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsGenomicSourceClass"> <valueCodeableConcept> <coding> <system value="http://loinc.org"/> <code value="LA6683-2"/> <display value="germline"/> </coding> </valueCodeableConcept> </extension> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsPhaseSet"> <valueUri value="urn:uuid:79383455-4f55-4126-bcc2-03385cad7944"/> </extension> <status value="final"/> <code> <coding> <system value="http://loinc.org"/> <code value="77636-9"/> <display value="HLA-C [Type] by High resolution"/> </coding> </code> <subject> <reference value="Patient/119"/> <display value="Mary Chalmers"/> </subject> <effectiveDateTime value="2016-12-15"/> <specimen> <reference value="Specimen/120"/> <display value="buccal swab from Mary Chalmers"/> </specimen> <related> <type value="derived-from"/> <target> <reference value="urn:uuid:bb55c2bc-5ad2-4bc1-8ff3-c407d06b12d0"/> <display value="HLA-C*01:02:01, exon 2"/> </target> </related> <related> <type value="derived-from"/> <target> <reference value="urn:uuid:46938bb2-0486-4e87-bfd3-89aab2d5e22f"/> <display value="HLA-C*01:02:01, exon 3"/> </target> </related> </Observation> </resource> <!-- transaction details --> <request> <method value="POST"/> <url value="Observation"/> </request> </entry> <entry> <fullUrl value="urn:uuid:8b2aa21c-1426-4717-8ab0-a84d83df7d47"/> <resource> <Observation> <text> <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml"><pre> HLA-C*03:04:01:01</pre> </div> </text> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsGene"> <valueCodeableConcept> <coding> <system value="http://www.genenames.org"/> <code value="HGNC:4933"/> <display value="HLA-C"/> </coding> </valueCodeableConcept> </extension> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsAlleleName"> <valueCodeableConcept> <coding> <system value="http://www.ebi.ac.uk/cgi-bin/ipd/imgt/hla/"/> <code value="C*03:04:01:01"/> <display value="HLA-C*03:04:01:01"/> </coding> </valueCodeableConcept> </extension> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsGenomicSourceClass"> <valueCodeableConcept> <coding> <system value="http://loinc.org"/> <code value="LA6683-2"/> <display value="germline"/> </coding> </valueCodeableConcept> </extension> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsPhaseSet"> <valueUri value="urn:uuid:a220b7a5-2d7a-4cec-a5b1-bfcf5890e391"/> </extension> <status value="final"/> <code> <coding> <system value="http://loinc.org"/> <code value="77636-9"/> <display value="HLA-C [Type] by High resolution"/> </coding> </code> <subject> <reference value="Patient/119"/> <display value="Mary Chalmers"/> </subject> <effectiveDateTime value="2016-12-15"/> <specimen> <reference value="Specimen/120"/> <display value="buccal swab from Mary Chalmers"/> </specimen> <related> <type value="derived-from"/> <target> <reference value="urn:uuid:2ae2ff34-279e-43c2-9018-b054fd3fc1ce"/> <display value="HLA-C*03:04:01:01, exon 2"/> </target> </related> <related> <type value="derived-from"/> <target> <reference value="urn:uuid:19153ef1-68c6-47a2-9676-c4eefbd39af9"/> <display value="HLA-C*03:04:01:01, exon 3"/> </target> </related> </Observation> </resource> <!-- transaction details --> <request> <method value="POST"/> <url value="Observation"/> </request> </entry> <entry> <fullUrl value="urn:uuid:0e0a780e-4486-4cd0-bfae-7243c579f208"/> <resource> <Observation> <text> <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml"><pre> HLA-C*01:02:01G+HLA-C*03:04:01G</pre> </div> </text> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsGene"> <valueCodeableConcept> <coding> <system value="http://www.genenames.org"/> <code value="HGNC:4933"/> <display value="HLA-C"/> </coding> </valueCodeableConcept> </extension> <extension url="http://hl7.org/fhir/StructureDefinition/observation-geneticsGenomicSourceClass"> <valueCodeableConcept> <coding> <system value="http://loinc.org"/> <code value="LA6683-2"/> <display value="germline"/> </coding> </valueCodeableConcept> </extension> <status value="final"/> <code> <coding> <system value="http://loinc.org"/> <code value="77636-9"/> <display value="HLA-C [Type] by High resolution"/> </coding> </code> <subject> <reference value="Patient/119"/> <display value="Mary Chalmers"/> </subject> <effectiveDateTime value="2016-12-15"/> <specimen> <reference value="Specimen/120"/> <display value="buccal swab from Mary Chalmers"/> </specimen> <related> <type value="derived-from"/> <target> <reference value="urn:uuid:709c5315-9403-4867-9d82-0b953836665f"/> <display value="HLA-C*01:02:01G, exons 2 and 3"/> </target> </related> <related> <type value="derived-from"/> <target> <reference value="urn:uuid:8b2aa21c-1426-4717-8ab0-a84d83df7d47"/> <display value="HLA-C*03:04:01G, exons 2 and 3"/> </target> </related> </Observation> </resource> <!-- transaction details --> <request> <method value="POST"/> <url value="Observation"/> </request> </entry> </Bundle>
Usage note: every effort has been made to ensure that the examples are correct and useful, but they are not a normative part of the specification.
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