A single issue - either an indication, contraindication, interaction or an undesirable effect for a medicinal product, medication, device or procedure.

A reference to a set of rules that were followed when the resource was constructed, and which must be understood when processing the content. Often, this is a reference to an implementation guide that defines the special rules along with other profiles etc.

Asserting this rule set restricts the content to be only understood by a limited set of trading partners. This inherently limits the usefulness of the data in the long term. However, the existing health eco-system is highly fractured, and not yet ready to define, collect, and exchange data in a generally computable sense. Wherever possible, implementers and/or specification writers should avoid using this element. Often, when used, the URL is a reference to an implementation guide that defines these special rules as part of it's narrative along with other profiles, value sets, etc.

An Extension

R5: ClinicalUseDefinition.library (new:canonical(Library))

Element ClinicalUseDefinition.library has a context of ClinicalUseDefinition based on following the parent source element upwards and mapping to ClinicalUseDefinition. Element ClinicalUseDefinition.library has no mapping targets in FHIR R4B. Typically, this is because the element has been added (is a new element).

May be used to represent additional information that is not part of the basic definition of the resource and that modifies the understanding of the element that contains it and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

indication | contraindication | interaction | undesirable-effect | warning.

Overall defining type of this clinical use definition.

R5: ClinicalUseDefinition.library (new:canonical(Library))

Element ClinicalUseDefinition.library has a context of ClinicalUseDefinition based on following the parent source element upwards and mapping to ClinicalUseDefinition. Element ClinicalUseDefinition.library has no mapping targets in FHIR R4B. Typically, this is because the element has been added (is a new element).

R5: ClinicalUseDefinition.identifier

Element ClinicalUseDefinition.identifier is mapped to FHIR R4B element ClinicalUseDefinition.identifier as Equivalent. An externally-defined extension that has been mapped as the representation of FHIR R5 element ClinicalUseDefinition.identifier: http://hl7.org/fhir/StructureDefinition/artifact-identifier.

R5: ClinicalUseDefinition.subject

Element ClinicalUseDefinition.subject is mapped to FHIR R4B element ClinicalUseDefinition.subject as SourceIsBroaderThanTarget. The standard extension alternate-reference has been mapped as the representation of FHIR R5 element ClinicalUseDefinition.subject with unmapped reference targets: BiologicallyDerivedProduct, NutritionProduct.

R5: ClinicalUseDefinition.status

Element ClinicalUseDefinition.status is mapped to FHIR R4B element ClinicalUseDefinition.status as Equivalent. An externally-defined extension that has been mapped as the representation of FHIR R5 element ClinicalUseDefinition.status: http://hl7.org/fhir/StructureDefinition/artifact-status.

R5: ClinicalUseDefinition.contraindication.applicability (new:Expression)

Element ClinicalUseDefinition.contraindication.applicability has a context of ClinicalUseDefinition.contraindication based on following the parent source element upwards and mapping to ClinicalUseDefinition. Element ClinicalUseDefinition.contraindication.applicability has no mapping targets in FHIR R4B. Typically, this is because the element has been added (is a new element). The expression may be inlined or may be a reference to a named expression within a logic library referenced by the library element.

R5: ClinicalUseDefinition.contraindication.otherTherapy.treatment additional types (CodeableReference(http://hl7.org/fhir/StructureDefinition/NutritionProduct), CodeableReference(http://hl7.org/fhir/StructureDefinition/BiologicallyDerivedProduct))

Element ClinicalUseDefinition.contraindication.otherTherapy.treatment is mapped to FHIR R4B element ClinicalUseDefinition.contraindication.otherTherapy.therapy as SourceIsBroaderThanTarget. The mappings for ClinicalUseDefinition.contraindication.otherTherapy.treatment do not cover the following types: CodeableReference.

R5: ClinicalUseDefinition.indication.applicability (new:Expression)

Element ClinicalUseDefinition.indication.applicability has a context of ClinicalUseDefinition.indication based on following the parent source element upwards and mapping to ClinicalUseDefinition. Element ClinicalUseDefinition.indication.applicability has no mapping targets in FHIR R4B. Typically, this is because the element has been added (is a new element). The expression may be inlined or may be a reference to a named expression within a logic library referenced by the library element.

R5: ClinicalUseDefinition.interaction.interactant.item[x]

Element ClinicalUseDefinition.interaction.interactant.item[x] is mapped to FHIR R4B element ClinicalUseDefinition.interaction.interactant.item[x] as SourceIsBroaderThanTarget. The standard extension alternate-reference has been mapped as the representation of FHIR R5 element ClinicalUseDefinition.interaction.interactant.item[x] with unmapped reference targets: BiologicallyDerivedProduct, NutritionProduct. Source element ClinicalUseDefinition.interaction.interactant.item[x] has unmapped reference types. While the target element ClinicalUseDefinition.interaction.interactant.item[x] is a choice type and does not allow extensions, the alternate-reference extension can be applied to Reference values within it.

A single issue - either an indication, contraindication, interaction or an undesirable effect for a medicinal product, medication, device or procedure.

The logical id of the resource, as used in the URL for the resource. Once assigned, this value never changes.

The only time that a resource does not have an id is when it is being submitted to the server using a create operation.

The metadata about the resource. This is content that is maintained by the infrastructure. Changes to the content might not always be associated with version changes to the resource.

A reference to a set of rules that were followed when the resource was constructed, and which must be understood when processing the content. Often, this is a reference to an implementation guide that defines the special rules along with other profiles etc.

Asserting this rule set restricts the content to be only understood by a limited set of trading partners. This inherently limits the usefulness of the data in the long term. However, the existing health eco-system is highly fractured, and not yet ready to define, collect, and exchange data in a generally computable sense. Wherever possible, implementers and/or specification writers should avoid using this element. Often, when used, the URL is a reference to an implementation guide that defines these special rules as part of it's narrative along with other profiles, value sets, etc.

The base language in which the resource is written.

Language is provided to support indexing and accessibility (typically, services such as text to speech use the language tag). The html language tag in the narrative applies to the narrative. The language tag on the resource may be used to specify the language of other presentations generated from the data in the resource. Not all the content has to be in the base language. The Resource.language should not be assumed to apply to the narrative automatically. If a language is specified, it should it also be specified on the div element in the html (see rules in HTML5 for information about the relationship between xml:lang and the html lang attribute).

IETF language tag

A human-readable narrative that contains a summary of the resource and can be used to represent the content of the resource to a human. The narrative need not encode all the structured data, but is required to contain sufficient detail to make it "clinically safe" for a human to just read the narrative. Resource definitions may define what content should be represented in the narrative to ensure clinical safety.

Contained resources do not have narrative. Resources that are not contained SHOULD have a narrative. In some cases, a resource may only have text with little or no additional discrete data (as long as all minOccurs=1 elements are satisfied). This may be necessary for data from legacy systems where information is captured as a "text blob" or where text is additionally entered raw or narrated and encoded information is added later.

These resources do not have an independent existence apart from the resource that contains them - they cannot be identified independently, and nor can they have their own independent transaction scope.

This should never be done when the content can be identified properly, as once identification is lost, it is extremely difficult (and context dependent) to restore it again. Contained resources may have profiles and tags In their meta elements, but SHALL NOT have security labels.

An Extension

R5: ClinicalUseDefinition.library (new:canonical(Library))

Element ClinicalUseDefinition.library has a context of ClinicalUseDefinition based on following the parent source element upwards and mapping to ClinicalUseDefinition. Element ClinicalUseDefinition.library has no mapping targets in FHIR R4B. Typically, this is because the element has been added (is a new element).

May be used to represent additional information that is not part of the basic definition of the resource and that modifies the understanding of the element that contains it and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

Business identifier for this issue.

Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

An Extension

R5: ClinicalUseDefinition.identifier

Element ClinicalUseDefinition.identifier is mapped to FHIR R4B element ClinicalUseDefinition.identifier as Equivalent. An externally-defined extension that has been mapped as the representation of FHIR R5 element ClinicalUseDefinition.identifier: http://hl7.org/fhir/StructureDefinition/artifact-identifier.

The purpose of this identifier.

Applications can assume that an identifier is permanent unless it explicitly says that it is temporary.

Allows the appropriate identifier for a particular context of use to be selected from among a set of identifiers.

A coded type for the identifier that can be used to determine which identifier to use for a specific purpose.

This element deals only with general categories of identifiers. It SHOULD not be used for codes that correspond 1..1 with the Identifier.system. Some identifiers may fall into multiple categories due to common usage. Where the system is known, a type is unnecessary because the type is always part of the system definition. However systems often need to handle identifiers where the system is not known. There is not a 1:1 relationship between type and system, since many different systems have the same type.

Allows users to make use of identifiers when the identifier system is not known.

Establishes the namespace for the value - that is, a URL that describes a set values that are unique.

Identifier.system is always case sensitive.

There are many sets of identifiers. To perform matching of two identifiers, we need to know what set we're dealing with. The system identifies a particular set of unique identifiers.

The portion of the identifier typically relevant to the user and which is unique within the context of the system.

If the value is a full URI, then the system SHALL be urn:ietf:rfc:3986. The value's primary purpose is computational mapping. As a result, it may be normalized for comparison purposes (e.g. removing non-significant whitespace, dashes, etc.) A value formatted for human display can be conveyed using the Rendered Value extension. Identifier.value is to be treated as case sensitive unless knowledge of the Identifier.system allows the processer to be confident that non-case-sensitive processing is safe.

Time period during which identifier is/was valid for use.

Organization that issued/manages the identifier.

The Identifier.assigner may omit the .reference element and only contain a .display element reflecting the name or other textual information about the assigning organization.

indication | contraindication | interaction | undesirable-effect | warning.

Overall defining type of this clinical use definition.

A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy and Lactation", "Overdose", "Effects on Ability to Drive and Use Machines".

A categorisation for a clinical use information item.

The medication or procedure for which this is an indication.

Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

An Extension

R5: ClinicalUseDefinition.subject

Element ClinicalUseDefinition.subject is mapped to FHIR R4B element ClinicalUseDefinition.subject as SourceIsBroaderThanTarget. The standard extension alternate-reference has been mapped as the representation of FHIR R5 element ClinicalUseDefinition.subject with unmapped reference targets: BiologicallyDerivedProduct, NutritionProduct.

A reference to a location at which the other resource is found. The reference may be a relative reference, in which case it is relative to the service base URL, or an absolute URL that resolves to the location where the resource is found. The reference may be version specific or not. If the reference is not to a FHIR RESTful server, then it should be assumed to be version specific. Internal fragment references (start with '#') refer to contained resources.

Using absolute URLs provides a stable scalable approach suitable for a cloud/web context, while using relative/logical references provides a flexible approach suitable for use when trading across closed eco-system boundaries. Absolute URLs do not need to point to a FHIR RESTful server, though this is the preferred approach. If the URL conforms to the structure "/[type]/[id]" then it should be assumed that the reference is to a FHIR RESTful server.

The expected type of the target of the reference. If both Reference.type and Reference.reference are populated and Reference.reference is a FHIR URL, both SHALL be consistent.

The type is the Canonical URL of Resource Definition that is the type this reference refers to. References are URLs that are relative to http://hl7.org/fhir/StructureDefinition/ e.g. "Patient" is a reference to http://hl7.org/fhir/StructureDefinition/Patient. Absolute URLs are only allowed for logical models (and can only be used in references in logical models, not resources).

This element is used to indicate the type of the target of the reference. This may be used which ever of the other elements are populated (or not). In some cases, the type of the target may be determined by inspection of the reference (e.g. a RESTful URL) or by resolving the target of the reference; if both the type and a reference is provided, the reference SHALL resolve to a resource of the same type as that specified.

An identifier for the target resource. This is used when there is no way to reference the other resource directly, either because the entity it represents is not available through a FHIR server, or because there is no way for the author of the resource to convert a known identifier to an actual location. There is no requirement that a Reference.identifier point to something that is actually exposed as a FHIR instance, but it SHALL point to a business concept that would be expected to be exposed as a FHIR instance, and that instance would need to be of a FHIR resource type allowed by the reference.

When an identifier is provided in place of a reference, any system processing the reference will only be able to resolve the identifier to a reference if it understands the business context in which the identifier is used. Sometimes this is global (e.g. a national identifier) but often it is not. For this reason, none of the useful mechanisms described for working with references (e.g. chaining, includes) are possible, nor should servers be expected to be able resolve the reference. Servers may accept an identifier based reference untouched, resolve it, and/or reject it - see CapabilityStatement.rest.resource.referencePolicy.

When both an identifier and a literal reference are provided, the literal reference is preferred. Applications processing the resource are allowed - but not required - to check that the identifier matches the literal reference

Applications converting a logical reference to a literal reference may choose to leave the logical reference present, or remove it.

Reference is intended to point to a structure that can potentially be expressed as a FHIR resource, though there is no need for it to exist as an actual FHIR resource instance - except in as much as an application wishes to actual find the target of the reference. The content referred to be the identifier must meet the logical constraints implied by any limitations on what resource types are permitted for the reference. For example, it would not be legitimate to send the identifier for a drug prescription if the type were Reference(Observation|DiagnosticReport). One of the use-cases for Reference.identifier is the situation where no FHIR representation exists (where the type is Reference (Any).

Plain text narrative that identifies the resource in addition to the resource reference.

This is generally not the same as the Resource.text of the referenced resource. The purpose is to identify what's being referenced, not to fully describe it.

Whether this is a current issue or one that has been retired etc.

The lifecycle status of an artifact.

Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

An Extension

R5: ClinicalUseDefinition.status

Element ClinicalUseDefinition.status is mapped to FHIR R4B element ClinicalUseDefinition.status as Equivalent. An externally-defined extension that has been mapped as the representation of FHIR R5 element ClinicalUseDefinition.status: http://hl7.org/fhir/StructureDefinition/artifact-status.

A reference to a code defined by a terminology system.

Codes may be defined very casually in enumerations, or code lists, up to very formal definitions such as SNOMED CT - see the HL7 v3 Core Principles for more information. Ordering of codings is undefined and SHALL NOT be used to infer meaning. Generally, at most only one of the coding values will be labeled as UserSelected = true.

Allows for alternative encodings within a code system, and translations to other code systems.

A human language representation of the concept as seen/selected/uttered by the user who entered the data and/or which represents the intended meaning of the user.

Very often the text is the same as a displayName of one of the codings.

The codes from the terminologies do not always capture the correct meaning with all the nuances of the human using them, or sometimes there is no appropriate code at all. In these cases, the text is used to capture the full meaning of the source.

Specifics for when this is a contraindication.

Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

An Extension

R5: ClinicalUseDefinition.contraindication.applicability (new:Expression)

Element ClinicalUseDefinition.contraindication.applicability has a context of ClinicalUseDefinition.contraindication based on following the parent source element upwards and mapping to ClinicalUseDefinition. Element ClinicalUseDefinition.contraindication.applicability has no mapping targets in FHIR R4B. Typically, this is because the element has been added (is a new element). The expression may be inlined or may be a reference to a named expression within a logic library referenced by the library element.

May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

The situation that is being documented as contraindicating against this item.

A symptom, disease or procedure.

The status of the disease or symptom for the contraindication, for example "chronic" or "metastatic".

The status of a disease or symptom.

A comorbidity (concurrent condition) or coinfection.

A symptom, disease or procedure.

The indication which this is a contraidication for.

Information about the use of the medicinal product in relation to other therapies described as part of the contraindication.

Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

The type of relationship between the medicinal product indication or contraindication and another therapy.

Classification of relationship between a therapy and a contraindication or an indication.

Reference to a specific medication (active substance, medicinal product or class of products) as part of an indication or contraindication.

A therapy.

Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

An Extension

R5: ClinicalUseDefinition.contraindication.otherTherapy.treatment additional types (CodeableReference(http://hl7.org/fhir/StructureDefinition/NutritionProduct), CodeableReference(http://hl7.org/fhir/StructureDefinition/BiologicallyDerivedProduct))

Element ClinicalUseDefinition.contraindication.otherTherapy.treatment is mapped to FHIR R4B element ClinicalUseDefinition.contraindication.otherTherapy.therapy as SourceIsBroaderThanTarget. The mappings for ClinicalUseDefinition.contraindication.otherTherapy.treatment do not cover the following types: CodeableReference.

A reference to a concept - e.g. the information is identified by its general class to the degree of precision found in the terminology.

A reference to a resource the provides exact details about the information being referenced.

Specifics for when this is an indication.

Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

An Extension

R5: ClinicalUseDefinition.indication.applicability (new:Expression)

Element ClinicalUseDefinition.indication.applicability has a context of ClinicalUseDefinition.indication based on following the parent source element upwards and mapping to ClinicalUseDefinition. Element ClinicalUseDefinition.indication.applicability has no mapping targets in FHIR R4B. Typically, this is because the element has been added (is a new element). The expression may be inlined or may be a reference to a named expression within a logic library referenced by the library element.

May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

The situation that is being documented as an indicaton for this item.

A symptom, disease or procedure.

The status of the disease or symptom for the indication, for example "chronic" or "metastatic".

The status of a disease or symptom.

A comorbidity (concurrent condition) or coinfection as part of the indication.

A symptom, disease or procedure.

The intended effect, aim or strategy to be achieved.

The overall intended use of a product.

Timing or duration information, that may be associated with use with the indicated condition e.g. Adult patients suffering from myocardial infarction (from a few days until less than 35 days), ischaemic stroke (from 7 days until less than 6 months).

An unwanted side effect or negative outcome that may happen if you use the drug (or other subject of this resource) for this indication.

Information about the use of the medicinal product in relation to other therapies described as part of the indication.

Specifics for when this is an interaction.

Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

The specific medication, food, substance or laboratory test that interacts.

Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

The specific medication, food or laboratory test that interacts.

An interactant - a substance that may have an clinically significant effect on another.

Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

An Extension

R5: ClinicalUseDefinition.interaction.interactant.item[x]

Element ClinicalUseDefinition.interaction.interactant.item[x] is mapped to FHIR R4B element ClinicalUseDefinition.interaction.interactant.item[x] as SourceIsBroaderThanTarget. The standard extension alternate-reference has been mapped as the representation of FHIR R5 element ClinicalUseDefinition.interaction.interactant.item[x] with unmapped reference targets: BiologicallyDerivedProduct, NutritionProduct. Source element ClinicalUseDefinition.interaction.interactant.item[x] has unmapped reference types. While the target element ClinicalUseDefinition.interaction.interactant.item[x] is a choice type and does not allow extensions, the alternate-reference extension can be applied to Reference values within it.

The type of the interaction e.g. drug-drug interaction, drug-food interaction, drug-lab test interaction.

A categorisation for an interaction between two substances.

The effect of the interaction, for example "reduced gastric absorption of primary medication".

A interaction effect of clinical use of a medication or other substance.

The incidence of the interaction, e.g. theoretical, observed.

A categorisation for incidence of occurence of an interaction.

Actions for managing the interaction.

A type of management for an interaction of a medication or other substance.

The population group to which this applies.

Describe the possible undesirable effects (negative outcomes) from the use of the medicinal product as treatment.

Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

The situation in which the undesirable effect may manifest.

An undesirable effect of clinical use.

High level classification of the effect.

A categorisation for an undesirable effect.

How often the effect is seen.

A categorisation for a frequency of occurence of an undesirable effect.

A critical piece of information about environmental, health or physical risks or hazards that serve as caution to the user. For example 'Do not operate heavy machinery', 'May cause drowsiness', or 'Get medical advice/attention if you feel unwell'.

Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

A textual definition of this warning, with formatting.

A coded or unformatted textual definition of this warning.

Classification of warning type.