<status value="active"/> <experimental value="false"/> <date value="2025-09-01T22:36:53.361952+10:00"/> <publisher value="FHIR Infrastructure"/> <contact> <name value="FHIR Infrastructure"/> <telecom> <system value="url"/> <value value="http://www.hl7.org/Special/committees/fiwg"/> </telecom> </contact> <description value="This cross-version extension represents MolecularSequence.referenceSeq from http://hl7.org/fhir/StructureDefinition/MolecularSequence|4.3.0 for use in FHIR R5."/> <jurisdiction> <coding> <system value="http://unstats.un.org/unsd/methods/m49/m49.htm"/> <code value="001"/> <display value="World"/> </coding> </jurisdiction> <fhirVersion value="5.0.0"/> <mapping> <identity value="rim"/> <uri value="http://hl7.org/v3"/> <name value="RIM Mapping"/> </mapping> <kind value="complex-type"/> <abstract value="false"/> <context> <type value="element"/> <expression value="MolecularSequence"/> </context> <type value="Extension"/> <baseDefinition value="http://hl7.org/fhir/StructureDefinition/Extension|5.0.0"/> <derivation value="constraint"/> <snapshot> <extension url="http://hl7.org/fhir/tools/StructureDefinition/snapshot-base-version"> <valueString value="5.0.0"/> </extension> <element id="Extension"> <path value="Extension"/> <short value="A sequence used as reference"/> <definition value="A sequence that is used as a reference to describe variants that are present in a sequence analyzed."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Extension"/> <min value="0"/> <max value="*"/> </base> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <constraint> <key value="ext-1"/> <severity value="error"/> <human value="Must have either extensions or value[x], not both"/> <expression value="extension.exists() != value.exists()"/> <source value="http://hl7.org/fhir/StructureDefinition/Extension|5.0.0"/> </constraint> <isModifier value="false"/> </element> <element id="Extension.id"> <path value="Extension.id"/> <representation value="xmlAttr"/> <short value="Unique id for inter-element referencing"/> <definition value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces."/> <min value="0"/> <max value="1"/> <base> <path value="Element.id"/> <min value="0"/> <max value="1"/> </base> <type> <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type"> <valueUrl value="id"/> </extension> <code value="http://hl7.org/fhirpath/System.String"/> </type> <condition value="ele-1"/> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="n/a"/> </mapping> </element> <element id="Extension.extension"> <path value="Extension.extension"/> <slicing> <discriminator> <type value="value"/> <path value="url"/> </discriminator> <description value="Extensions are always sliced by (at least) url"/> <ordered value="false"/> <rules value="closed"/> </slicing> <short value="Extension"/> <definition value="An Extension"/> <min value="0"/> <max value="*"/> <base> <path value="Element.extension"/> <min value="0"/> <max value="*"/> </base> <type> <code value="Extension"/> </type> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <constraint> <key value="ext-1"/> <severity value="error"/> <human value="Must have either extensions or value[x], not both"/> <expression value="extension.exists() != value.exists()"/> <source value="http://hl7.org/fhir/StructureDefinition/Extension|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> </element> <element id="Extension.extension:chromosome"> <path value="Extension.extension"/> <sliceName value="chromosome"/> <short value="Chromosome containing genetic finding"/> <definition value="Structural unit composed of a nucleic acid molecule which controls its own replication through the interaction of specific proteins at one or more origins of replication ([SO:0000340](http://www.sequenceontology.org/browser/current_svn/term/SO:0000340))."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Element.extension"/> <min value="0"/> <max value="*"/> </base> <type> <code value="Extension"/> </type> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <constraint> <key value="ext-1"/> <severity value="error"/> <human value="Must have either extensions or value[x], not both"/> <expression value="extension.exists() != value.exists()"/> <source value="http://hl7.org/fhir/StructureDefinition/Extension|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> </element> <element id="Extension.extension:chromosome.id"> <path value="Extension.extension.id"/> <representation value="xmlAttr"/> <short value="Unique id for inter-element referencing"/> <definition value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces."/> <min value="0"/> <max value="1"/> <base> <path value="Element.id"/> <min value="0"/> <max value="1"/> </base> <type> <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type"> <valueUrl value="id"/> </extension> <code value="http://hl7.org/fhirpath/System.String"/> </type> <condition value="ele-1"/> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="n/a"/> </mapping> </element> <element id="Extension.extension:chromosome.extension"> <path value="Extension.extension.extension"/> <slicing> <discriminator> <type value="value"/> <path value="url"/> </discriminator> <description value="Extensions are always sliced by (at least) url"/> <rules value="open"/> </slicing> <short value="Additional content defined by implementations"/> <definition value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension."/> <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/> <alias value="extensions"/> <alias value="user content"/> <min value="0"/> <max value="*"/> <base> <path value="Element.extension"/> <min value="0"/> <max value="*"/> </base> <type> <code value="Extension"/> </type> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <constraint> <key value="ext-1"/> <severity value="error"/> <human value="Must have either extensions or value[x], not both"/> <expression value="extension.exists() != value.exists()"/> <source value="http://hl7.org/fhir/StructureDefinition/Extension|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="n/a"/> </mapping> </element> <element id="Extension.extension:chromosome.url"> <path value="Extension.extension.url"/> <representation value="xmlAttr"/> <short value="identifies the meaning of the extension"/> <definition value="Source of the definition for the extension code - a logical name or a URL."/> <comment value="The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension."/> <min value="1"/> <max value="1"/> <base> <path value="Extension.url"/> <min value="1"/> <max value="1"/> </base> <type> <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type"> <valueUrl value="uri"/> </extension> <code value="http://hl7.org/fhirpath/System.String"/> </type> <fixedUri value="chromosome"/> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="N/A"/> </mapping> </element> <element id="Extension.extension:chromosome.value[x]"> <path value="Extension.extension.value[x]"/> <short value="Chromosome containing genetic finding"/> <definition value="Structural unit composed of a nucleic acid molecule which controls its own replication through the interaction of specific proteins at one or more origins of replication ([SO:0000340](http://www.sequenceontology.org/browser/current_svn/term/SO:0000340))."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Extension.value[x]"/> <min value="0"/> <max value="1"/> </base> <type> <code value="CodeableConcept"/> </type> <condition value="ext-1"/> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> <binding> <strength value="example"/> <description value="The chromosome containing the genetic finding"/> <valueSet value="http://terminology.hl7.org/ValueSet/chromosome-human|0.2.0"/> </binding> <mapping> <identity value="rim"/> <map value="N/A"/> </mapping> </element> <element id="Extension.extension:genomeBuild"> <path value="Extension.extension"/> <sliceName value="genomeBuild"/> <short value="The Genome Build used for reference, following GRCh build versions e.g. 'GRCh 37'"/> <definition value="The Genome Build used for reference, following GRCh build versions e.g. 'GRCh 37'. Version number must be included if a versioned release of a primary build was used."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Element.extension"/> <min value="0"/> <max value="*"/> </base> <type> <code value="Extension"/> </type> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <constraint> <key value="ext-1"/> <severity value="error"/> <human value="Must have either extensions or value[x], not both"/> <expression value="extension.exists() != value.exists()"/> <source value="http://hl7.org/fhir/StructureDefinition/Extension|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> </element> <element id="Extension.extension:genomeBuild.id"> <path value="Extension.extension.id"/> <representation value="xmlAttr"/> <short value="Unique id for inter-element referencing"/> <definition value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces."/> <min value="0"/> <max value="1"/> <base> <path value="Element.id"/> <min value="0"/> <max value="1"/> </base> <type> <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type"> <valueUrl value="id"/> </extension> <code value="http://hl7.org/fhirpath/System.String"/> </type> <condition value="ele-1"/> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="n/a"/> </mapping> </element> <element id="Extension.extension:genomeBuild.extension"> <path value="Extension.extension.extension"/> <slicing> <discriminator> <type value="value"/> <path value="url"/> </discriminator> <description value="Extensions are always sliced by (at least) url"/> <rules value="open"/> </slicing> <short value="Additional content defined by implementations"/> <definition value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension."/> <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/> <alias value="extensions"/> <alias value="user content"/> <min value="0"/> <max value="*"/> <base> <path value="Element.extension"/> <min value="0"/> <max value="*"/> </base> <type> <code value="Extension"/> </type> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <constraint> <key value="ext-1"/> <severity value="error"/> <human value="Must have either extensions or value[x], not both"/> <expression value="extension.exists() != value.exists()"/> <source value="http://hl7.org/fhir/StructureDefinition/Extension|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="n/a"/> </mapping> </element> <element id="Extension.extension:genomeBuild.url"> <path value="Extension.extension.url"/> <representation value="xmlAttr"/> <short value="identifies the meaning of the extension"/> <definition value="Source of the definition for the extension code - a logical name or a URL."/> <comment value="The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension."/> <min value="1"/> <max value="1"/> <base> <path value="Extension.url"/> <min value="1"/> <max value="1"/> </base> <type> <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type"> <valueUrl value="uri"/> </extension> <code value="http://hl7.org/fhirpath/System.String"/> </type> <fixedUri value="genomeBuild"/> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="N/A"/> </mapping> </element> <element id="Extension.extension:genomeBuild.value[x]"> <path value="Extension.extension.value[x]"/> <short value="The Genome Build used for reference, following GRCh build versions e.g. 'GRCh 37'"/> <definition value="The Genome Build used for reference, following GRCh build versions e.g. 'GRCh 37'. Version number must be included if a versioned release of a primary build was used."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Extension.value[x]"/> <min value="0"/> <max value="1"/> </base> <type> <code value="string"/> </type> <condition value="ext-1"/> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="N/A"/> </mapping> </element> <element id="Extension.extension:orientation"> <path value="Extension.extension"/> <sliceName value="orientation"/> <short value="sense | antisense"/> <definition value="A relative reference to a DNA strand based on gene orientation. The strand that contains the open reading frame of the gene is the "sense" strand, and the opposite complementary strand is the "antisense" strand."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Element.extension"/> <min value="0"/> <max value="*"/> </base> <type> <code value="Extension"/> </type> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <constraint> <key value="ext-1"/> <severity value="error"/> <human value="Must have either extensions or value[x], not both"/> <expression value="extension.exists() != value.exists()"/> <source value="http://hl7.org/fhir/StructureDefinition/Extension|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> </element> <element id="Extension.extension:orientation.id"> <path value="Extension.extension.id"/> <representation value="xmlAttr"/> <short value="Unique id for inter-element referencing"/> <definition value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces."/> <min value="0"/> <max value="1"/> <base> <path value="Element.id"/> <min value="0"/> <max value="1"/> </base> <type> <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type"> <valueUrl value="id"/> </extension> <code value="http://hl7.org/fhirpath/System.String"/> </type> <condition value="ele-1"/> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="n/a"/> </mapping> </element> <element id="Extension.extension:orientation.extension"> <path value="Extension.extension.extension"/> <slicing> <discriminator> <type value="value"/> <path value="url"/> </discriminator> <description value="Extensions are always sliced by (at least) url"/> <rules value="open"/> </slicing> <short value="Additional content defined by implementations"/> <definition value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension."/> <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/> <alias value="extensions"/> <alias value="user content"/> <min value="0"/> <max value="*"/> <base> <path value="Element.extension"/> <min value="0"/> <max value="*"/> </base> <type> <code value="Extension"/> </type> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <constraint> <key value="ext-1"/> <severity value="error"/> <human value="Must have either extensions or value[x], not both"/> <expression value="extension.exists() != value.exists()"/> <source value="http://hl7.org/fhir/StructureDefinition/Extension|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="n/a"/> </mapping> </element> <element id="Extension.extension:orientation.url"> <path value="Extension.extension.url"/> <representation value="xmlAttr"/> <short value="identifies the meaning of the extension"/> <definition value="Source of the definition for the extension code - a logical name or a URL."/> <comment value="The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension."/> <min value="1"/> <max value="1"/> <base> <path value="Extension.url"/> <min value="1"/> <max value="1"/> </base> <type> <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type"> <valueUrl value="uri"/> </extension> <code value="http://hl7.org/fhirpath/System.String"/> </type> <fixedUri value="orientation"/> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="N/A"/> </mapping> </element> <element id="Extension.extension:orientation.value[x]"> <path value="Extension.extension.value[x]"/> <short value="sense | antisense"/> <definition value="A relative reference to a DNA strand based on gene orientation. The strand that contains the open reading frame of the gene is the "sense" strand, and the opposite complementary strand is the "antisense" strand."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Extension.value[x]"/> <min value="0"/> <max value="1"/> </base> <type> <code value="code"/> </type> <condition value="ext-1"/> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> <binding> <strength value="required"/> <description value="Type for orientation"/> <valueSet value="http://hl7.org/fhir/ValueSet/orientation-type|5.0.0"/> </binding> <mapping> <identity value="rim"/> <map value="N/A"/> </mapping> </element> <element id="Extension.extension:referenceSeqId"> <path value="Extension.extension"/> <sliceName value="referenceSeqId"/> <short value="Reference identifier"/> <definition value="Reference identifier of reference sequence submitted to NCBI. It must match the type in the MolecularSequence.type field. For example, the prefix, “NG_” identifies reference sequence for genes, “NM_” for messenger RNA transcripts, and “NP_” for amino acid sequences."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Element.extension"/> <min value="0"/> <max value="*"/> </base> <type> <code value="Extension"/> </type> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <constraint> <key value="ext-1"/> <severity value="error"/> <human value="Must have either extensions or value[x], not both"/> <expression value="extension.exists() != value.exists()"/> <source value="http://hl7.org/fhir/StructureDefinition/Extension|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> </element> <element id="Extension.extension:referenceSeqId.id"> <path value="Extension.extension.id"/> <representation value="xmlAttr"/> <short value="Unique id for inter-element referencing"/> <definition value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces."/> <min value="0"/> <max value="1"/> <base> <path value="Element.id"/> <min value="0"/> <max value="1"/> </base> <type> <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type"> <valueUrl value="id"/> </extension> <code value="http://hl7.org/fhirpath/System.String"/> </type> <condition value="ele-1"/> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="n/a"/> </mapping> </element> <element id="Extension.extension:referenceSeqId.extension"> <path value="Extension.extension.extension"/> <slicing> <discriminator> <type value="value"/> <path value="url"/> </discriminator> <description value="Extensions are always sliced by (at least) url"/> <rules value="open"/> </slicing> <short value="Additional content defined by implementations"/> <definition value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension."/> <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/> <alias value="extensions"/> <alias value="user content"/> <min value="0"/> <max value="*"/> <base> <path value="Element.extension"/> <min value="0"/> <max value="*"/> </base> <type> <code value="Extension"/> </type> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <constraint> <key value="ext-1"/> <severity value="error"/> <human value="Must have either extensions or value[x], not both"/> <expression value="extension.exists() != value.exists()"/> <source value="http://hl7.org/fhir/StructureDefinition/Extension|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="n/a"/> </mapping> </element> <element id="Extension.extension:referenceSeqId.url"> <path value="Extension.extension.url"/> <representation value="xmlAttr"/> <short value="identifies the meaning of the extension"/> <definition value="Source of the definition for the extension code - a logical name or a URL."/> <comment value="The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension."/> <min value="1"/> <max value="1"/> <base> <path value="Extension.url"/> <min value="1"/> <max value="1"/> </base> <type> <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type"> <valueUrl value="uri"/> </extension> <code value="http://hl7.org/fhirpath/System.String"/> </type> <fixedUri value="referenceSeqId"/> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="N/A"/> </mapping> </element> <element id="Extension.extension:referenceSeqId.value[x]"> <path value="Extension.extension.value[x]"/> <short value="Reference identifier"/> <definition value="Reference identifier of reference sequence submitted to NCBI. It must match the type in the MolecularSequence.type field. For example, the prefix, “NG_” identifies reference sequence for genes, “NM_” for messenger RNA transcripts, and “NP_” for amino acid sequences."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Extension.value[x]"/> <min value="0"/> <max value="1"/> </base> <type> <code value="CodeableConcept"/> </type> <condition value="ext-1"/> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> <binding> <strength value="example"/> <description value="Reference identifier for reference sequence"/> <valueSet value="http://hl7.org/fhir/4.3/ValueSet/R4B-sequence-referenceSeq-for-R5|0.0.1-snapshot-2"/> </binding> <mapping> <identity value="rim"/> <map value="N/A"/> </mapping> </element> <element id="Extension.extension:referenceSeqPointer"> <path value="Extension.extension"/> <sliceName value="referenceSeqPointer"/> <short value="A pointer to another MolecularSequence entity as reference sequence"/> <definition value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Element.extension"/> <min value="0"/> <max value="*"/> </base> <type> <code value="Extension"/> </type> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <constraint> <key value="ext-1"/> <severity value="error"/> <human value="Must have either extensions or value[x], not both"/> <expression value="extension.exists() != value.exists()"/> <source value="http://hl7.org/fhir/StructureDefinition/Extension|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> </element> <element id="Extension.extension:referenceSeqPointer.id"> <path value="Extension.extension.id"/> <representation value="xmlAttr"/> <short value="Unique id for inter-element referencing"/> <definition value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces."/> <min value="0"/> <max value="1"/> <base> <path value="Element.id"/> <min value="0"/> <max value="1"/> </base> <type> <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type"> <valueUrl value="id"/> </extension> <code value="http://hl7.org/fhirpath/System.String"/> </type> <condition value="ele-1"/> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="n/a"/> </mapping> </element> <element id="Extension.extension:referenceSeqPointer.extension"> <path value="Extension.extension.extension"/> <slicing> <discriminator> <type value="value"/> <path value="url"/> </discriminator> <description value="Extensions are always sliced by (at least) url"/> <rules value="open"/> </slicing> <short value="Additional content defined by implementations"/> <definition value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension."/> <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/> <alias value="extensions"/> <alias value="user content"/> <min value="0"/> <max value="*"/> <base> <path value="Element.extension"/> <min value="0"/> <max value="*"/> </base> <type> <code value="Extension"/> </type> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <constraint> <key value="ext-1"/> <severity value="error"/> <human value="Must have either extensions or value[x], not both"/> <expression value="extension.exists() != value.exists()"/> <source value="http://hl7.org/fhir/StructureDefinition/Extension|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="n/a"/> </mapping> </element> <element id="Extension.extension:referenceSeqPointer.url"> <path value="Extension.extension.url"/> <representation value="xmlAttr"/> <short value="identifies the meaning of the extension"/> <definition value="Source of the definition for the extension code - a logical name or a URL."/> <comment value="The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension."/> <min value="1"/> <max value="1"/> <base> <path value="Extension.url"/> <min value="1"/> <max value="1"/> </base> <type> <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type"> <valueUrl value="uri"/> </extension> <code value="http://hl7.org/fhirpath/System.String"/> </type> <fixedUri value="referenceSeqPointer"/> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="N/A"/> </mapping> </element> <element id="Extension.extension:referenceSeqPointer.value[x]"> <path value="Extension.extension.value[x]"/> <short value="A pointer to another MolecularSequence entity as reference sequence"/> <definition value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Extension.value[x]"/> <min value="0"/> <max value="1"/> </base> <type> <code value="Reference"/> </type> <condition value="ext-1"/> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="N/A"/> </mapping> </element> <element id="Extension.extension:referenceSeqString"> <path value="Extension.extension"/> <sliceName value="referenceSeqString"/> <short value="A string to represent reference sequence"/> <definition value="A string like "ACGT"."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Element.extension"/> <min value="0"/> <max value="*"/> </base> <type> <code value="Extension"/> </type> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <constraint> <key value="ext-1"/> <severity value="error"/> <human value="Must have either extensions or value[x], not both"/> <expression value="extension.exists() != value.exists()"/> <source value="http://hl7.org/fhir/StructureDefinition/Extension|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> </element> <element id="Extension.extension:referenceSeqString.id"> <path value="Extension.extension.id"/> <representation value="xmlAttr"/> <short value="Unique id for inter-element referencing"/> <definition value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces."/> <min value="0"/> <max value="1"/> <base> <path value="Element.id"/> <min value="0"/> <max value="1"/> </base> <type> <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type"> <valueUrl value="id"/> </extension> <code value="http://hl7.org/fhirpath/System.String"/> </type> <condition value="ele-1"/> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="n/a"/> </mapping> </element> <element id="Extension.extension:referenceSeqString.extension"> <path value="Extension.extension.extension"/> <slicing> <discriminator> <type value="value"/> <path value="url"/> </discriminator> <description value="Extensions are always sliced by (at least) url"/> <rules value="open"/> </slicing> <short value="Additional content defined by implementations"/> <definition value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension."/> <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/> <alias value="extensions"/> <alias value="user content"/> <min value="0"/> <max value="*"/> <base> <path value="Element.extension"/> <min value="0"/> <max value="*"/> </base> <type> <code value="Extension"/> </type> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <constraint> <key value="ext-1"/> <severity value="error"/> <human value="Must have either extensions or value[x], not both"/> <expression value="extension.exists() != value.exists()"/> <source value="http://hl7.org/fhir/StructureDefinition/Extension|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="n/a"/> </mapping> </element> <element id="Extension.extension:referenceSeqString.url"> <path value="Extension.extension.url"/> <representation value="xmlAttr"/> <short value="identifies the meaning of the extension"/> <definition value="Source of the definition for the extension code - a logical name or a URL."/> <comment value="The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension."/> <min value="1"/> <max value="1"/> <base> <path value="Extension.url"/> <min value="1"/> <max value="1"/> </base> <type> <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type"> <valueUrl value="uri"/> </extension> <code value="http://hl7.org/fhirpath/System.String"/> </type> <fixedUri value="referenceSeqString"/> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="N/A"/> </mapping> </element> <element id="Extension.extension:referenceSeqString.value[x]"> <path value="Extension.extension.value[x]"/> <short value="A string to represent reference sequence"/> <definition value="A string like "ACGT"."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Extension.value[x]"/> <min value="0"/> <max value="1"/> </base> <type> <code value="string"/> </type> <condition value="ext-1"/> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="N/A"/> </mapping> </element> <element id="Extension.extension:strand"> <path value="Extension.extension"/> <sliceName value="strand"/> <short value="watson | crick"/> <definition value="An absolute reference to a strand. The Watson strand is the strand whose 5'-end is on the short arm of the chromosome, and the Crick strand as the one whose 5'-end is on the long arm."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Element.extension"/> <min value="0"/> <max value="*"/> </base> <type> <code value="Extension"/> </type> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <constraint> <key value="ext-1"/> <severity value="error"/> <human value="Must have either extensions or value[x], not both"/> <expression value="extension.exists() != value.exists()"/> <source value="http://hl7.org/fhir/StructureDefinition/Extension|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> </element> <element id="Extension.extension:strand.id"> <path value="Extension.extension.id"/> <representation value="xmlAttr"/> <short value="Unique id for inter-element referencing"/> <definition value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces."/> <min value="0"/> <max value="1"/> <base> <path value="Element.id"/> <min value="0"/> <max value="1"/> </base> <type> <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type"> <valueUrl value="id"/> </extension> <code value="http://hl7.org/fhirpath/System.String"/> </type> <condition value="ele-1"/> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="n/a"/> </mapping> </element> <element id="Extension.extension:strand.extension"> <path value="Extension.extension.extension"/> <slicing> <discriminator> <type value="value"/> <path value="url"/> </discriminator> <description value="Extensions are always sliced by (at least) url"/> <rules value="open"/> </slicing> <short value="Additional content defined by implementations"/> <definition value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension."/> <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/> <alias value="extensions"/> <alias value="user content"/> <min value="0"/> <max value="*"/> <base> <path value="Element.extension"/> <min value="0"/> <max value="*"/> </base> <type> <code value="Extension"/> </type> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <constraint> <key value="ext-1"/> <severity value="error"/> <human value="Must have either extensions or value[x], not both"/> <expression value="extension.exists() != value.exists()"/> <source value="http://hl7.org/fhir/StructureDefinition/Extension|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="n/a"/> </mapping> </element> <element id="Extension.extension:strand.url"> <path value="Extension.extension.url"/> <representation value="xmlAttr"/> <short value="identifies the meaning of the extension"/> <definition value="Source of the definition for the extension code - a logical name or a URL."/> <comment value="The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension."/> <min value="1"/> <max value="1"/> <base> <path value="Extension.url"/> <min value="1"/> <max value="1"/> </base> <type> <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type"> <valueUrl value="uri"/> </extension> <code value="http://hl7.org/fhirpath/System.String"/> </type> <fixedUri value="strand"/> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="N/A"/> </mapping> </element> <element id="Extension.extension:strand.value[x]"> <path value="Extension.extension.value[x]"/> <short value="watson | crick"/> <definition value="An absolute reference to a strand. The Watson strand is the strand whose 5'-end is on the short arm of the chromosome, and the Crick strand as the one whose 5'-end is on the long arm."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Extension.value[x]"/> <min value="0"/> <max value="1"/> </base> <type> <code value="code"/> </type> <condition value="ext-1"/> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> <binding> <strength value="required"/> <description value="Type for strand"/> <valueSet value="http://hl7.org/fhir/ValueSet/strand-type|5.0.0"/> </binding> <mapping> <identity value="rim"/> <map value="N/A"/> </mapping> </element> <element id="Extension.extension:windowStart"> <path value="Extension.extension"/> <sliceName value="windowStart"/> <short value="Start position of the window on the reference sequence"/> <definition value="Start position of the window on the reference sequence. If the coordinate system is either 0-based or 1-based, then start position is inclusive."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Element.extension"/> <min value="0"/> <max value="*"/> </base> <type> <code value="Extension"/> </type> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <constraint> <key value="ext-1"/> <severity value="error"/> <human value="Must have either extensions or value[x], not both"/> <expression value="extension.exists() != value.exists()"/> <source value="http://hl7.org/fhir/StructureDefinition/Extension|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> </element> <element id="Extension.extension:windowStart.id"> <path value="Extension.extension.id"/> <representation value="xmlAttr"/> <short value="Unique id for inter-element referencing"/> <definition value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces."/> <min value="0"/> <max value="1"/> <base> <path value="Element.id"/> <min value="0"/> <max value="1"/> </base> <type> <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type"> <valueUrl value="id"/> </extension> <code value="http://hl7.org/fhirpath/System.String"/> </type> <condition value="ele-1"/> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="n/a"/> </mapping> </element> <element id="Extension.extension:windowStart.extension"> <path value="Extension.extension.extension"/> <slicing> <discriminator> <type value="value"/> <path value="url"/> </discriminator> <description value="Extensions are always sliced by (at least) url"/> <rules value="open"/> </slicing> <short value="Additional content defined by implementations"/> <definition value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension."/> <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/> <alias value="extensions"/> <alias value="user content"/> <min value="0"/> <max value="*"/> <base> <path value="Element.extension"/> <min value="0"/> <max value="*"/> </base> <type> <code value="Extension"/> </type> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <constraint> <key value="ext-1"/> <severity value="error"/> <human value="Must have either extensions or value[x], not both"/> <expression value="extension.exists() != value.exists()"/> <source value="http://hl7.org/fhir/StructureDefinition/Extension|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="n/a"/> </mapping> </element> <element id="Extension.extension:windowStart.url"> <path value="Extension.extension.url"/> <representation value="xmlAttr"/> <short value="identifies the meaning of the extension"/> <definition value="Source of the definition for the extension code - a logical name or a URL."/> <comment value="The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension."/> <min value="1"/> <max value="1"/> <base> <path value="Extension.url"/> <min value="1"/> <max value="1"/> </base> <type> <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type"> <valueUrl value="uri"/> </extension> <code value="http://hl7.org/fhirpath/System.String"/> </type> <fixedUri value="windowStart"/> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="N/A"/> </mapping> </element> <element id="Extension.extension:windowStart.value[x]"> <path value="Extension.extension.value[x]"/> <short value="Start position of the window on the reference sequence"/> <definition value="Start position of the window on the reference sequence. If the coordinate system is either 0-based or 1-based, then start position is inclusive."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Extension.value[x]"/> <min value="0"/> <max value="1"/> </base> <type> <code value="integer"/> </type> <condition value="ext-1"/> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="N/A"/> </mapping> </element> <element id="Extension.extension:windowEnd"> <path value="Extension.extension"/> <sliceName value="windowEnd"/> <short value="End position of the window on the reference sequence"/> <definition value="End position of the window on the reference sequence. If the coordinate system is 0-based then end is exclusive and does not include the last position. If the coordinate system is 1-base, then end is inclusive and includes the last position."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Element.extension"/> <min value="0"/> <max value="*"/> </base> <type> <code value="Extension"/> </type> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <constraint> <key value="ext-1"/> <severity value="error"/> <human value="Must have either extensions or value[x], not both"/> <expression value="extension.exists() != value.exists()"/> <source value="http://hl7.org/fhir/StructureDefinition/Extension|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> </element> <element id="Extension.extension:windowEnd.id"> <path value="Extension.extension.id"/> <representation value="xmlAttr"/> <short value="Unique id for inter-element referencing"/> <definition value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces."/> <min value="0"/> <max value="1"/> <base> <path value="Element.id"/> <min value="0"/> <max value="1"/> </base> <type> <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type"> <valueUrl value="id"/> </extension> <code value="http://hl7.org/fhirpath/System.String"/> </type> <condition value="ele-1"/> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="n/a"/> </mapping> </element> <element id="Extension.extension:windowEnd.extension"> <path value="Extension.extension.extension"/> <slicing> <discriminator> <type value="value"/> <path value="url"/> </discriminator> <description value="Extensions are always sliced by (at least) url"/> <rules value="open"/> </slicing> <short value="Additional content defined by implementations"/> <definition value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension."/> <comment value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/> <alias value="extensions"/> <alias value="user content"/> <min value="0"/> <max value="*"/> <base> <path value="Element.extension"/> <min value="0"/> <max value="*"/> </base> <type> <code value="Extension"/> </type> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <constraint> <key value="ext-1"/> <severity value="error"/> <human value="Must have either extensions or value[x], not both"/> <expression value="extension.exists() != value.exists()"/> <source value="http://hl7.org/fhir/StructureDefinition/Extension|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="n/a"/> </mapping> </element> <element id="Extension.extension:windowEnd.url"> <path value="Extension.extension.url"/> <representation value="xmlAttr"/> <short value="identifies the meaning of the extension"/> <definition value="Source of the definition for the extension code - a logical name or a URL."/> <comment value="The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension."/> <min value="1"/> <max value="1"/> <base> <path value="Extension.url"/> <min value="1"/> <max value="1"/> </base> <type> <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type"> <valueUrl value="uri"/> </extension> <code value="http://hl7.org/fhirpath/System.String"/> </type> <fixedUri value="windowEnd"/> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="N/A"/> </mapping> </element> <element id="Extension.extension:windowEnd.value[x]"> <path value="Extension.extension.value[x]"/> <short value="End position of the window on the reference sequence"/> <definition value="End position of the window on the reference sequence. If the coordinate system is 0-based then end is exclusive and does not include the last position. If the coordinate system is 1-base, then end is inclusive and includes the last position."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Extension.value[x]"/> <min value="0"/> <max value="1"/> </base> <type> <code value="integer"/> </type> <condition value="ext-1"/> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="N/A"/> </mapping> </element> <element id="Extension.url"> <path value="Extension.url"/> <representation value="xmlAttr"/> <short value="identifies the meaning of the extension"/> <definition value="Source of the definition for the extension code - a logical name or a URL."/> <comment value="The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension."/> <min value="1"/> <max value="1"/> <base> <path value="Extension.url"/> <min value="1"/> <max value="1"/> </base> <type> <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type"> <valueUrl value="uri"/> </extension> <code value="http://hl7.org/fhirpath/System.String"/> </type> <fixedUri value="http://hl7.org/fhir/4.3/StructureDefinition/extension-MolecularSequence.referenceSeq"/> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="N/A"/> </mapping> </element> <element id="Extension.value[x]"> <path value="Extension.value[x]"/> <short value="Value of extension"/> <definition value="Value of extension - must be one of a constrained set of the data types (see [Extensibility](http://hl7.org/fhir/R5/extensibility.html) for a list)."/> <min value="0"/> <max value="1"/> <base> <path value="Extension.value[x]"/> <min value="0"/> <max value="1"/> </base> <type> <code value="base64Binary"/> </type> <type> <code value="boolean"/> </type> <type> <code value="canonical"/> </type> <type> <code value="code"/> </type> <type> <code value="date"/> </type> <type> <code value="dateTime"/> </type> <type> <code value="decimal"/> </type> <type> <code value="id"/> </type> <type> <code value="instant"/> </type> <type> <code value="integer"/> </type> <type> <code value="integer64"/> </type> <type> <code value="markdown"/> </type> <type> <code value="oid"/> </type> <type> <code value="positiveInt"/> </type> <type> <code value="string"/> </type> <type> <code value="time"/> </type> <type> <code value="unsignedInt"/> </type> <type> <code value="uri"/> </type> <type> <code value="url"/> </type> <type> <code value="uuid"/> </type> <type> <code value="Address"/> </type> <type> <code value="Age"/> </type> <type> <code value="Annotation"/> </type> <type> <code value="Attachment"/> </type> <type> <code value="CodeableConcept"/> </type> <type> <code value="CodeableReference"/> </type> <type> <code value="Coding"/> </type> <type> <code value="ContactPoint"/> </type> <type> <code value="Count"/> </type> <type> <code value="Distance"/> </type> <type> <code value="Duration"/> </type> <type> <code value="HumanName"/> </type> <type> <code value="Identifier"/> </type> <type> <code value="Money"/> </type> <type> <code value="Period"/> </type> <type> <code value="Quantity"/> </type> <type> <code value="Range"/> </type> <type> <code value="Ratio"/> </type> <type> <code value="RatioRange"/> </type> <type> <code value="Reference"/> </type> <type> <code value="SampledData"/> </type> <type> <code value="Signature"/> </type> <type> <code value="Timing"/> </type> <type> <code value="ContactDetail"/> </type> <type> <code value="DataRequirement"/> </type> <type> <code value="Expression"/> </type> <type> <code value="ParameterDefinition"/> </type> <type> <code value="RelatedArtifact"/> </type> <type> <code value="TriggerDefinition"/> </type> <type> <code value="UsageContext"/> </type> <type> <code value="Availability"/> </type> <type> <code value="ExtendedContactDetail"/> </type> <type> <code value="Dosage"/> </type> <type> <code value="Meta"/> </type> <condition value="ext-1"/> <constraint> <key value="ele-1"/> <severity value="error"/> <human value="All FHIR elements must have a @value or children"/> <expression value="hasValue() or (children().count() > id.count())"/> <source value="http://hl7.org/fhir/StructureDefinition/Element|5.0.0"/> </constraint> <isModifier value="false"/> <isSummary value="false"/> <mapping> <identity value="rim"/> <map value="N/A"/> </mapping> </element> </snapshot> <differential> <element id="Extension"> <path value="Extension"/> <short value="A sequence used as reference"/> <definition value="A sequence that is used as a reference to describe variants that are present in a sequence analyzed."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Extension"/> <min value="0"/> <max value="*"/> </base> </element> <element id="Extension.extension"> <path value="Extension.extension"/> <slicing> <discriminator> <type value="value"/> <path value="url"/> </discriminator> <ordered value="false"/> <rules value="closed"/> </slicing> <min value="0"/> <max value="*"/> <base> <path value="Extension.extension"/> <min value="0"/> <max value="*"/> </base> </element> <element id="Extension.extension:chromosome"> <path value="Extension.extension"/> <sliceName value="chromosome"/> <short value="Chromosome containing genetic finding"/> <definition value="Structural unit composed of a nucleic acid molecule which controls its own replication through the interaction of specific proteins at one or more origins of replication ([SO:0000340](http://www.sequenceontology.org/browser/current_svn/term/SO:0000340))."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Extension.extension"/> <min value="0"/> <max value="*"/> </base> </element> <element id="Extension.extension:chromosome.url"> <path value="Extension.extension.url"/> <min value="1"/> <max value="1"/> <base> <path value="Extension.url"/> <min value="1"/> <max value="1"/> </base> <fixedUri value="chromosome"/> </element> <element id="Extension.extension:chromosome.value[x]"> <path value="Extension.extension.value[x]"/> <short value="Chromosome containing genetic finding"/> <definition value="Structural unit composed of a nucleic acid molecule which controls its own replication through the interaction of specific proteins at one or more origins of replication ([SO:0000340](http://www.sequenceontology.org/browser/current_svn/term/SO:0000340))."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <base> <path value="Extension.value[x]"/> <min value="0"/> <max value="1"/> </base> <type> <code value="CodeableConcept"/> </type> <binding> <strength value="example"/> <description value="The chromosome containing the genetic finding"/> <valueSet value="http://terminology.hl7.org/ValueSet/chromosome-human|0.2.0"/> </binding> </element> <element id="Extension.extension:genomeBuild"> <path value="Extension.extension"/> <sliceName value="genomeBuild"/> <short value="The Genome Build used for reference, following GRCh build versions e.g. 'GRCh 37'"/> <definition value="The Genome Build used for reference, following GRCh build versions e.g. 'GRCh 37'. Version number must be included if a versioned release of a primary build was used."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Extension.extension"/> <min value="0"/> <max value="*"/> </base> </element> <element id="Extension.extension:genomeBuild.url"> <path value="Extension.extension.url"/> <min value="1"/> <max value="1"/> <base> <path value="Extension.url"/> <min value="1"/> <max value="1"/> </base> <fixedUri value="genomeBuild"/> </element> <element id="Extension.extension:genomeBuild.value[x]"> <path value="Extension.extension.value[x]"/> <short value="The Genome Build used for reference, following GRCh build versions e.g. 'GRCh 37'"/> <definition value="The Genome Build used for reference, following GRCh build versions e.g. 'GRCh 37'. Version number must be included if a versioned release of a primary build was used."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <base> <path value="Extension.value[x]"/> <min value="0"/> <max value="1"/> </base> <type> <code value="string"/> </type> </element> <element id="Extension.extension:orientation"> <path value="Extension.extension"/> <sliceName value="orientation"/> <short value="sense | antisense"/> <definition value="A relative reference to a DNA strand based on gene orientation. The strand that contains the open reading frame of the gene is the "sense" strand, and the opposite complementary strand is the "antisense" strand."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Extension.extension"/> <min value="0"/> <max value="*"/> </base> </element> <element id="Extension.extension:orientation.url"> <path value="Extension.extension.url"/> <min value="1"/> <max value="1"/> <base> <path value="Extension.url"/> <min value="1"/> <max value="1"/> </base> <fixedUri value="orientation"/> </element> <element id="Extension.extension:orientation.value[x]"> <path value="Extension.extension.value[x]"/> <short value="sense | antisense"/> <definition value="A relative reference to a DNA strand based on gene orientation. The strand that contains the open reading frame of the gene is the "sense" strand, and the opposite complementary strand is the "antisense" strand."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <base> <path value="Extension.value[x]"/> <min value="0"/> <max value="1"/> </base> <type> <code value="code"/> </type> <binding> <strength value="required"/> <description value="Type for orientation"/> <valueSet value="http://hl7.org/fhir/ValueSet/orientation-type|5.0.0"/> </binding> </element> <element id="Extension.extension:referenceSeqId"> <path value="Extension.extension"/> <sliceName value="referenceSeqId"/> <short value="Reference identifier"/> <definition value="Reference identifier of reference sequence submitted to NCBI. It must match the type in the MolecularSequence.type field. For example, the prefix, “NG_” identifies reference sequence for genes, “NM_” for messenger RNA transcripts, and “NP_” for amino acid sequences."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Extension.extension"/> <min value="0"/> <max value="*"/> </base> </element> <element id="Extension.extension:referenceSeqId.url"> <path value="Extension.extension.url"/> <min value="1"/> <max value="1"/> <base> <path value="Extension.url"/> <min value="1"/> <max value="1"/> </base> <fixedUri value="referenceSeqId"/> </element> <element id="Extension.extension:referenceSeqId.value[x]"> <path value="Extension.extension.value[x]"/> <short value="Reference identifier"/> <definition value="Reference identifier of reference sequence submitted to NCBI. It must match the type in the MolecularSequence.type field. For example, the prefix, “NG_” identifies reference sequence for genes, “NM_” for messenger RNA transcripts, and “NP_” for amino acid sequences."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <base> <path value="Extension.value[x]"/> <min value="0"/> <max value="1"/> </base> <type> <code value="CodeableConcept"/> </type> <binding> <strength value="example"/> <description value="Reference identifier for reference sequence"/> <valueSet value="http://hl7.org/fhir/4.3/ValueSet/R4B-sequence-referenceSeq-for-R5|0.0.1-snapshot-2"/> </binding> </element> <element id="Extension.extension:referenceSeqPointer"> <path value="Extension.extension"/> <sliceName value="referenceSeqPointer"/> <short value="A pointer to another MolecularSequence entity as reference sequence"/> <definition value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Extension.extension"/> <min value="0"/> <max value="*"/> </base> </element> <element id="Extension.extension:referenceSeqPointer.url"> <path value="Extension.extension.url"/> <min value="1"/> <max value="1"/> <base> <path value="Extension.url"/> <min value="1"/> <max value="1"/> </base> <fixedUri value="referenceSeqPointer"/> </element> <element id="Extension.extension:referenceSeqPointer.value[x]"> <path value="Extension.extension.value[x]"/> <short value="A pointer to another MolecularSequence entity as reference sequence"/> <definition value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <base> <path value="Extension.value[x]"/> <min value="0"/> <max value="1"/> </base> <type> <code value="Reference"/> </type> </element> <element id="Extension.extension:referenceSeqString"> <path value="Extension.extension"/> <sliceName value="referenceSeqString"/> <short value="A string to represent reference sequence"/> <definition value="A string like "ACGT"."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Extension.extension"/> <min value="0"/> <max value="*"/> </base> </element> <element id="Extension.extension:referenceSeqString.url"> <path value="Extension.extension.url"/> <min value="1"/> <max value="1"/> <base> <path value="Extension.url"/> <min value="1"/> <max value="1"/> </base> <fixedUri value="referenceSeqString"/> </element> <element id="Extension.extension:referenceSeqString.value[x]"> <path value="Extension.extension.value[x]"/> <short value="A string to represent reference sequence"/> <definition value="A string like "ACGT"."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <base> <path value="Extension.value[x]"/> <min value="0"/> <max value="1"/> </base> <type> <code value="string"/> </type> </element> <element id="Extension.extension:strand"> <path value="Extension.extension"/> <sliceName value="strand"/> <short value="watson | crick"/> <definition value="An absolute reference to a strand. The Watson strand is the strand whose 5'-end is on the short arm of the chromosome, and the Crick strand as the one whose 5'-end is on the long arm."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Extension.extension"/> <min value="0"/> <max value="*"/> </base> </element> <element id="Extension.extension:strand.url"> <path value="Extension.extension.url"/> <min value="1"/> <max value="1"/> <base> <path value="Extension.url"/> <min value="1"/> <max value="1"/> </base> <fixedUri value="strand"/> </element> <element id="Extension.extension:strand.value[x]"> <path value="Extension.extension.value[x]"/> <short value="watson | crick"/> <definition value="An absolute reference to a strand. The Watson strand is the strand whose 5'-end is on the short arm of the chromosome, and the Crick strand as the one whose 5'-end is on the long arm."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <base> <path value="Extension.value[x]"/> <min value="0"/> <max value="1"/> </base> <type> <code value="code"/> </type> <binding> <strength value="required"/> <description value="Type for strand"/> <valueSet value="http://hl7.org/fhir/ValueSet/strand-type|5.0.0"/> </binding> </element> <element id="Extension.extension:windowStart"> <path value="Extension.extension"/> <sliceName value="windowStart"/> <short value="Start position of the window on the reference sequence"/> <definition value="Start position of the window on the reference sequence. If the coordinate system is either 0-based or 1-based, then start position is inclusive."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Extension.extension"/> <min value="0"/> <max value="*"/> </base> </element> <element id="Extension.extension:windowStart.url"> <path value="Extension.extension.url"/> <min value="1"/> <max value="1"/> <base> <path value="Extension.url"/> <min value="1"/> <max value="1"/> </base> <fixedUri value="windowStart"/> </element> <element id="Extension.extension:windowStart.value[x]"> <path value="Extension.extension.value[x]"/> <short value="Start position of the window on the reference sequence"/> <definition value="Start position of the window on the reference sequence. If the coordinate system is either 0-based or 1-based, then start position is inclusive."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <base> <path value="Extension.value[x]"/> <min value="0"/> <max value="1"/> </base> <type> <code value="integer"/> </type> </element> <element id="Extension.extension:windowEnd"> <path value="Extension.extension"/> <sliceName value="windowEnd"/> <short value="End position of the window on the reference sequence"/> <definition value="End position of the window on the reference sequence. If the coordinate system is 0-based then end is exclusive and does not include the last position. If the coordinate system is 1-base, then end is inclusive and includes the last position."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <min value="0"/> <max value="1"/> <base> <path value="Extension.extension"/> <min value="0"/> <max value="*"/> </base> </element> <element id="Extension.extension:windowEnd.url"> <path value="Extension.extension.url"/> <min value="1"/> <max value="1"/> <base> <path value="Extension.url"/> <min value="1"/> <max value="1"/> </base> <fixedUri value="windowEnd"/> </element> <element id="Extension.extension:windowEnd.value[x]"> <path value="Extension.extension.value[x]"/> <short value="End position of the window on the reference sequence"/> <definition value="End position of the window on the reference sequence. If the coordinate system is 0-based then end is exclusive and does not include the last position. If the coordinate system is 1-base, then end is inclusive and includes the last position."/> <comment value="`MolecularSequence.referenceSeq` has no related element in R5:MolecularSequence"/> <base> <path value="Extension.value[x]"/> <min value="0"/> <max value="1"/> </base> <type> <code value="integer"/> </type> </element> <element id="Extension.url"> <path value="Extension.url"/> <min value="1"/> <max value="1"/> <base> <path value="Extension.url"/> <min value="1"/> <max value="1"/> </base> <fixedUri value="http://hl7.org/fhir/4.3/StructureDefinition/extension-MolecularSequence.referenceSeq"/> </element> </differential> </StructureDefinition>

Generated Narrative: StructureDefinition ext-R4B-MolecularSequence.referenceSeq

Name	Card.	Type	Description & Constraints
Extension	0..1	Extension(5.0.0)	A sequence used as reference
Slices for extension	0..*	Extension	Extension Slice: Unordered, Closed by value:url
extension:chromosome	0..1	Extension	Chromosome containing genetic finding
url	1..1	uri	"chromosome"
value[x]	0..1	CodeableConcept	Chromosome containing genetic finding Binding: http://terminology.hl7.org/ValueSet/chromosome-human\|0.2.0 (example): The chromosome containing the genetic finding
extension:genomeBuild	0..1	Extension	The Genome Build used for reference, following GRCh build versions e.g. 'GRCh 37'
url	1..1	uri	"genomeBuild"
value[x]	0..1	string	The Genome Build used for reference, following GRCh build versions e.g. 'GRCh 37'
extension:orientation	0..1	Extension	sense \| antisense
url	1..1	uri	"orientation"
value[x]	0..1	code	sense \| antisense Binding: OrientationType (required): Type for orientation
extension:referenceSeqId	0..1	Extension	Reference identifier
url	1..1	uri	"referenceSeqId"
value[x]	0..1	CodeableConcept	Reference identifier Binding: R4B_sequence_referenceSeq_for_R5 (0.0.1-snapshot-2) (example): Reference identifier for reference sequence
extension:referenceSeqPointer	0..1	Extension	A pointer to another MolecularSequence entity as reference sequence
url	1..1	uri	"referenceSeqPointer"
value[x]	0..1	Reference()	A pointer to another MolecularSequence entity as reference sequence
extension:referenceSeqString	0..1	Extension	A string to represent reference sequence
url	1..1	uri	"referenceSeqString"
value[x]	0..1	string	A string to represent reference sequence
extension:strand	0..1	Extension	watson \| crick
url	1..1	uri	"strand"
value[x]	0..1	code	watson \| crick Binding: StrandType (required): Type for strand
extension:windowStart	0..1	Extension	Start position of the window on the reference sequence
url	1..1	uri	"windowStart"
value[x]	0..1	integer	Start position of the window on the reference sequence
extension:windowEnd	0..1	Extension	End position of the window on the reference sequence
url	1..1	uri	"windowEnd"
value[x]	0..1	integer	End position of the window on the reference sequence
url	1..1	uri	"http://hl7.org/fhir/4.3/StructureDefinition/extension-MolecularSequence.referenceSeq"
Documentation for this format