ext-R4-SubstanceProtein
type: StructureDefinition
node role: treeRoot
id:
  v: ext-R4-SubstanceProtein
text:
  status:
    v: extensions
  div: Generated Narrative: StructureDefinition ext-R4-SubstanceProtein Name Flags Card. Type Description & Constraints<img src="[binary]" alt="doco" style="background-color: inherit"/> Extension 0..* Extension(4.3.0) A SubstanceProtein is defined as a single unit of a linear amino acid sequence, or a combination of subunits that are either covalently linked or have a defined invariant stoichiometric relationship. This includes all synthetic, recombinant and purified SubstanceProteins of defined sequence, whether the use is therapeutic or prophylactic. This set of elements will be used to describe albumins, coagulation factors, cytokines, growth factors, peptide/SubstanceProtein hormones, enzymes, toxins, toxoids, recombinant vaccines, and immunomodulators #xD; Slices for extension 0..* Extension Extension Slice: Unordered, Closed by value:url #xD; extension:sequenceType 0..1 Extension The SubstanceProtein descriptive elements will only be used when a complete or partial amino acid sequence is available or derivable from a nucleic acid sequence #xD; url 1..1 uri "sequenceType" #xD; value[x] 0..1 CodeableConcept The SubstanceProtein descriptive elements will only be used when a complete or partial amino acid sequence is available or derivable from a nucleic acid sequence #xD; extension:numberOfSubunits 0..1 Extension Number of linear sequences of amino acids linked through peptide bonds. The number of subunits constituting the SubstanceProtein shall be described. It is possible that the number of subunits can be variable #xD; url 1..1 uri "numberOfSubunits" #xD; value[x] 0..1 integer Number of linear sequences of amino acids linked through peptide bonds. The number of subunits constituting the SubstanceProtein shall be described. It is possible that the number of subunits can be variable #xD; extension:disulfideLinkage 0..* Extension The disulphide bond between two cysteine residues either on the same subunit or on two different subunits shall be described. The position of …
extension:
  url:
    v: http://hl7.org/fhir/StructureDefinition/structuredefinition-wg
  value: code
    v: fhir
extension:
  extension:
    url:
      v: packageId
    value: id
      v: hl7.fhir.uv.xver-r4.r4b
  extension:
    url:
      v: version
    value: string
      v: 0.0.1-snapshot-2
  url:
    v: http://hl7.org/fhir/StructureDefinition/package-source
extension:
  url:
    v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm
  value: integer
    v: 0
    extension:
      url:
        v: http://hl7.org/fhir/StructureDefinition/structuredefinition-conformance-derivedFrom
      value: canonical
        v: http://hl7.org/fhir/4.0/ImplementationGuide/hl7.fhir.uv.xver-r4.r4b
        link: http://hl7.org/fhir/4.0/ImplementationGuide/hl7.fhir.uv.xver-r4.r4b
extension:
  url:
    v: http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status
  value: code
    v: trial-use
    extension:
      url:
        v: http://hl7.org/fhir/StructureDefinition/structuredefinition-conformance-derivedFrom
      value: canonical
        v: http://hl7.org/fhir/4.0/ImplementationGuide/hl7.fhir.uv.xver-r4.r4b
        link: http://hl7.org/fhir/4.0/ImplementationGuide/hl7.fhir.uv.xver-r4.r4b
url:
  v: http://hl7.org/fhir/4.0/StructureDefinition/extension-SubstanceProtein
version:
  v: 0.0.1-snapshot-2
name:
  v: Ext_R4_SubstanceProtein
title:
  v: Cross-version Extension for R4.SubstanceProtein for use in FHIR R4B
status:
  v: active
experimental:
  v: false
date:
  v: 2025-09-01T22:36:34.31088+10:00
publisher:
  v: FHIR Infrastructure
contact:
  name:
    v: FHIR Infrastructure
  telecom:
    system:
      v: url
    value:
      v: http://www.hl7.org/Special/committees/fiwg
description:
  v: This cross-version extension represents SubstanceProtein from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
jurisdiction:
  coding:
    system:
      v: http://unstats.un.org/unsd/methods/m49/m49.htm
    code:
      v: 001
    display:
      v: World
fhir version:
  v: 4.3.0
mapping:
  identity:
    v: rim
  uri:
    v: http://hl7.org/v3
  name:
    v: RIM Mapping
kind:
  v: complex-type
abstract:
  v: false
context:
  type:
    v: element
  expression:
    v: Basic
type:
  v: Extension
base definition:
  v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
  link: 4.3
  link: .0
derivation:
  v: constraint
snapshot:
  extension:
    url:
      v: http://hl7.org/fhir/tools/StructureDefinition/snapshot-base-version
    value: string
      v: 4.3.0
  element:
    id:
      v: Extension
    path:
      v: Extension
    short:
      v: A SubstanceProtein is defined as a single unit of a linear amino acid sequence, or a combination of subunits that are either covalently linked or have a defined invariant stoichiometric relationship. This includes all synthetic, recombinant and purified SubstanceProteins of defined sequence, whether the use is therapeutic or prophylactic. This set of elements will be used to describe albumins, coagulation factors, cytokines, growth factors, peptide/SubstanceProtein hormones, enzymes, toxins, toxoids, recombinant vaccines, and immunomodulators
    definition:
      v: This cross-version extension represents SubstanceProtein from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
    min:
      v: 0
    max:
      v: *
    base:
      path:
        v: Extension
      min:
        v: 0
      max:
        v: *
    condition:
      v: ele-1
    constraint:
      key:
        v: ele-1
      severity:
        v: error
      human:
        v: All FHIR elements must have a @value or children unless an empty Parameters resource
      expression:
        v: hasValue() or (children().count() > id.count()) or $this is Parameters
      xpath:
        v: @value|f:*|h:div|self::f:Parameters
      source:
        v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
        link: 4.3
        link: .0
    constraint:
      key:
        v: ext-1
      severity:
        v: error
      human:
        v: Must have either extensions or value[x], not both
      expression:
        v: extension.exists() != value.exists()
      xpath:
        v: exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])
      source:
        v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
        link: 4.3
        link: .0
    is modifier:
      v: false
  element:
    id:
      v: Extension.id
    path:
      v: Extension.id
    representation:
      v: xmlAttr
    short:
      v: Unique id for inter-element referencing
    definition:
      v: Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
    min:
      v: 0
    max:
      v: 1
    base:
      path:
        v: Element.id
      min:
        v: 0
      max:
        v: 1
    type:
      extension:
        value: url
      code:
        v: http://hl7.org/fhirpath/System.String
    is modifier:
      v: false
    is summary:
      v: false
    mapping:
      identity:
        v: rim
      map:
        v: n/a

url
v: id

id:
  v: Extension.extension
path:
  v: Extension.extension
slicing:
  discriminator:
    type:
      v: value
    path:
      v: url
  description:
    v: Extensions are always sliced by (at least) url
  ordered:
    v: false
  rules:
    v: closed
short:
  v: Extension
definition:
  v: An Extension
min:
  v: 0
max:
  v: *
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  xpath:
    v: exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false

id:
  v: Extension.extension:sequenceType
path:
  v: Extension.extension
slice name:
  v: sequenceType
short:
  v: The SubstanceProtein descriptive elements will only be used when a complete or partial amino acid sequence is available or derivable from a nucleic acid sequence
definition:
  v: This cross-version extension represents SubstanceProtein.sequenceType from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  xpath:
    v: exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false

id:
  v: Extension.extension:sequenceType.id
path:
  v: Extension.extension.id
representation:
  v: xmlAttr
short:
  v: Unique id for inter-element referencing
definition:
  v: Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Element.id
  min:
    v: 0
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
    value: url
      v: id
  code:
    v: http://hl7.org/fhirpath/System.String
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: Extension.extension:sequenceType.extension
path:
  v: Extension.extension.extension
slicing:
  discriminator:
    type:
      v: value
    path:
      v: url
  description:
    v: Extensions are always sliced by (at least) url
  rules:
    v: open
short:
  v: Additional content defined by implementations
definition:
  v: May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
comment:
  v: There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
alias:
  v: extensions
alias:
  v: user content
min:
  v: 0
max:
  v: *
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  xpath:
    v: exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: Extension.extension:sequenceType.url
path:
  v: Extension.extension.url
representation:
  v: xmlAttr
short:
  v: identifies the meaning of the extension
definition:
  v: Source of the definition for the extension code - a logical name or a URL.
comment:
  v: The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
min:
  v: 1
max:
  v: 1
base:
  path:
    v: Extension.url
  min:
    v: 1
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
    value: url
      v: uri
  code:
    v: http://hl7.org/fhirpath/System.String
fixed: uri
  v: sequenceType
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: Extension.extension:sequenceType.value[x]
path:
  v: Extension.extension.value[x]
short:
  v: The SubstanceProtein descriptive elements will only be used when a complete or partial amino acid sequence is available or derivable from a nucleic acid sequence
definition:
  v: This cross-version extension represents SubstanceProtein.sequenceType from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Extension.value[x]
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: CodeableConcept
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: Extension.extension:numberOfSubunits
path:
  v: Extension.extension
slice name:
  v: numberOfSubunits
short:
  v: Number of linear sequences of amino acids linked through peptide bonds. The number of subunits constituting the SubstanceProtein shall be described. It is possible that the number of subunits can be variable
definition:
  v: This cross-version extension represents SubstanceProtein.numberOfSubunits from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  xpath:
    v: exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false

id:
  v: Extension.extension:numberOfSubunits.id
path:
  v: Extension.extension.id
representation:
  v: xmlAttr
short:
  v: Unique id for inter-element referencing
definition:
  v: Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Element.id
  min:
    v: 0
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
    value: url
      v: id
  code:
    v: http://hl7.org/fhirpath/System.String
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: Extension.extension:numberOfSubunits.extension
path:
  v: Extension.extension.extension
slicing:
  discriminator:
    type:
      v: value
    path:
      v: url
  description:
    v: Extensions are always sliced by (at least) url
  rules:
    v: open
short:
  v: Additional content defined by implementations
definition:
  v: May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
comment:
  v: There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
alias:
  v: extensions
alias:
  v: user content
min:
  v: 0
max:
  v: *
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  xpath:
    v: exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: Extension.extension:numberOfSubunits.url
path:
  v: Extension.extension.url
representation:
  v: xmlAttr
short:
  v: identifies the meaning of the extension
definition:
  v: Source of the definition for the extension code - a logical name or a URL.
comment:
  v: The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
min:
  v: 1
max:
  v: 1
base:
  path:
    v: Extension.url
  min:
    v: 1
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
    value: url
      v: uri
  code:
    v: http://hl7.org/fhirpath/System.String
fixed: uri
  v: numberOfSubunits
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: Extension.extension:numberOfSubunits.value[x]
path:
  v: Extension.extension.value[x]
short:
  v: Number of linear sequences of amino acids linked through peptide bonds. The number of subunits constituting the SubstanceProtein shall be described. It is possible that the number of subunits can be variable
definition:
  v: This cross-version extension represents SubstanceProtein.numberOfSubunits from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Extension.value[x]
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: integer
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: Extension.extension:disulfideLinkage
path:
  v: Extension.extension
slice name:
  v: disulfideLinkage
short:
  v: The disulphide bond between two cysteine residues either on the same subunit or on two different subunits shall be described. The position of the disulfide bonds in the SubstanceProtein shall be listed in increasing order of subunit number and position within subunit followed by the abbreviation of the amino acids involved. The disulfide linkage positions shall actually contain the amino acid Cysteine at the respective positions
definition:
  v: This cross-version extension represents SubstanceProtein.disulfideLinkage from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: *
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  xpath:
    v: exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false

id:
  v: Extension.extension:disulfideLinkage.id
path:
  v: Extension.extension.id
representation:
  v: xmlAttr
short:
  v: Unique id for inter-element referencing
definition:
  v: Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Element.id
  min:
    v: 0
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
    value: url
      v: id
  code:
    v: http://hl7.org/fhirpath/System.String
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: Extension.extension:disulfideLinkage.extension
path:
  v: Extension.extension.extension
slicing:
  discriminator:
    type:
      v: value
    path:
      v: url
  description:
    v: Extensions are always sliced by (at least) url
  rules:
    v: open
short:
  v: Additional content defined by implementations
definition:
  v: May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
comment:
  v: There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
alias:
  v: extensions
alias:
  v: user content
min:
  v: 0
max:
  v: *
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  xpath:
    v: exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: Extension.extension:disulfideLinkage.url
path:
  v: Extension.extension.url
representation:
  v: xmlAttr
short:
  v: identifies the meaning of the extension
definition:
  v: Source of the definition for the extension code - a logical name or a URL.
comment:
  v: The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
min:
  v: 1
max:
  v: 1
base:
  path:
    v: Extension.url
  min:
    v: 1
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
    value: url
      v: uri
  code:
    v: http://hl7.org/fhirpath/System.String
fixed: uri
  v: disulfideLinkage
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: Extension.extension:disulfideLinkage.value[x]
path:
  v: Extension.extension.value[x]
short:
  v: The disulphide bond between two cysteine residues either on the same subunit or on two different subunits shall be described. The position of the disulfide bonds in the SubstanceProtein shall be listed in increasing order of subunit number and position within subunit followed by the abbreviation of the amino acids involved. The disulfide linkage positions shall actually contain the amino acid Cysteine at the respective positions
definition:
  v: This cross-version extension represents SubstanceProtein.disulfideLinkage from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Extension.value[x]
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: string
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: Extension.extension:subunit
path:
  v: Extension.extension
slice name:
  v: subunit
short:
  v: This subclause refers to the description of each subunit constituting the SubstanceProtein. A subunit is a linear sequence of amino acids linked through peptide bonds. The Subunit information shall be provided when the finished SubstanceProtein is a complex of multiple sequences; subunits are not used to delineate domains within a single sequence. Subunits are listed in order of decreasing length; sequences of the same length will be ordered by decreasing molecular weight; subunits that have identical sequences will be repeated multiple times
definition:
  v: This cross-version extension represents SubstanceProtein.subunit from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: *
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  xpath:
    v: exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false

id:
  v: Extension.extension:subunit.id
path:
  v: Extension.extension.id
representation:
  v: xmlAttr
short:
  v: Unique id for inter-element referencing
definition:
  v: Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Element.id
  min:
    v: 0
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
    value: url
      v: id
  code:
    v: http://hl7.org/fhirpath/System.String
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: Extension.extension:subunit.extension
path:
  v: Extension.extension.extension
slicing:
  discriminator:
    type:
      v: value
    path:
      v: url
  description:
    v: Extensions are always sliced by (at least) url
  ordered:
    v: false
  rules:
    v: closed
short:
  v: Extension
definition:
  v: An Extension
min:
  v: 0
max:
  v: *
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  xpath:
    v: exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false

id:
  v: Extension.extension:subunit.extension:subunit
path:
  v: Extension.extension.extension
slice name:
  v: subunit
short:
  v: Index of primary sequences of amino acids linked through peptide bonds in order of decreasing length. Sequences of the same length will be ordered by molecular weight. Subunits that have identical sequences will be repeated and have sequential subscripts
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.subunit from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  xpath:
    v: exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false

id:
  v: Extension.extension:subunit.extension:subunit.id
path:
  v: Extension.extension.extension.id
representation:
  v: xmlAttr
short:
  v: Unique id for inter-element referencing
definition:
  v: Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Element.id
  min:
    v: 0
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
    value: url
      v: id
  code:
    v: http://hl7.org/fhirpath/System.String
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: Extension.extension:subunit.extension:subunit.extension
path:
  v: Extension.extension.extension.extension
slicing:
  discriminator:
    type:
      v: value
    path:
      v: url
  description:
    v: Extensions are always sliced by (at least) url
  rules:
    v: open
short:
  v: Additional content defined by implementations
definition:
  v: May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
comment:
  v: There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
alias:
  v: extensions
alias:
  v: user content
min:
  v: 0
max:
  v: *
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  xpath:
    v: exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: Extension.extension:subunit.extension:subunit.url
path:
  v: Extension.extension.extension.url
representation:
  v: xmlAttr
short:
  v: identifies the meaning of the extension
definition:
  v: Source of the definition for the extension code - a logical name or a URL.
comment:
  v: The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
min:
  v: 1
max:
  v: 1
base:
  path:
    v: Extension.url
  min:
    v: 1
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
    value: url
      v: uri
  code:
    v: http://hl7.org/fhirpath/System.String
fixed: uri
  v: subunit
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: Extension.extension:subunit.extension:subunit.value[x]
path:
  v: Extension.extension.extension.value[x]
short:
  v: Index of primary sequences of amino acids linked through peptide bonds in order of decreasing length. Sequences of the same length will be ordered by molecular weight. Subunits that have identical sequences will be repeated and have sequential subscripts
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.subunit from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Extension.value[x]
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: integer
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: Extension.extension:subunit.extension:sequence
path:
  v: Extension.extension.extension
slice name:
  v: sequence
short:
  v: The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.sequence from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  xpath:
    v: exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false

id:
  v: Extension.extension:subunit.extension:sequence.id
path:
  v: Extension.extension.extension.id
representation:
  v: xmlAttr
short:
  v: Unique id for inter-element referencing
definition:
  v: Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Element.id
  min:
    v: 0
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
    value: url
      v: id
  code:
    v: http://hl7.org/fhirpath/System.String
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: Extension.extension:subunit.extension:sequence.extension
path:
  v: Extension.extension.extension.extension
slicing:
  discriminator:
    type:
      v: value
    path:
      v: url
  description:
    v: Extensions are always sliced by (at least) url
  rules:
    v: open
short:
  v: Additional content defined by implementations
definition:
  v: May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
comment:
  v: There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
alias:
  v: extensions
alias:
  v: user content
min:
  v: 0
max:
  v: *
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  xpath:
    v: exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: Extension.extension:subunit.extension:sequence.url
path:
  v: Extension.extension.extension.url
representation:
  v: xmlAttr
short:
  v: identifies the meaning of the extension
definition:
  v: Source of the definition for the extension code - a logical name or a URL.
comment:
  v: The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
min:
  v: 1
max:
  v: 1
base:
  path:
    v: Extension.url
  min:
    v: 1
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
    value: url
      v: uri
  code:
    v: http://hl7.org/fhirpath/System.String
fixed: uri
  v: sequence
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: Extension.extension:subunit.extension:sequence.value[x]
path:
  v: Extension.extension.extension.value[x]
short:
  v: The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.sequence from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Extension.value[x]
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: string
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: Extension.extension:subunit.extension:length
path:
  v: Extension.extension.extension
slice name:
  v: length
short:
  v: Length of linear sequences of amino acids contained in the subunit
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.length from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  xpath:
    v: exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false

id:
  v: Extension.extension:subunit.extension:length.id
path:
  v: Extension.extension.extension.id
representation:
  v: xmlAttr
short:
  v: Unique id for inter-element referencing
definition:
  v: Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Element.id
  min:
    v: 0
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
    value: url
      v: id
  code:
    v: http://hl7.org/fhirpath/System.String
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: Extension.extension:subunit.extension:length.extension
path:
  v: Extension.extension.extension.extension
slicing:
  discriminator:
    type:
      v: value
    path:
      v: url
  description:
    v: Extensions are always sliced by (at least) url
  rules:
    v: open
short:
  v: Additional content defined by implementations
definition:
  v: May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
comment:
  v: There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
alias:
  v: extensions
alias:
  v: user content
min:
  v: 0
max:
  v: *
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  xpath:
    v: exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: Extension.extension:subunit.extension:length.url
path:
  v: Extension.extension.extension.url
representation:
  v: xmlAttr
short:
  v: identifies the meaning of the extension
definition:
  v: Source of the definition for the extension code - a logical name or a URL.
comment:
  v: The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
min:
  v: 1
max:
  v: 1
base:
  path:
    v: Extension.url
  min:
    v: 1
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
    value: url
      v: uri
  code:
    v: http://hl7.org/fhirpath/System.String
fixed: uri
  v: length
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: Extension.extension:subunit.extension:length.value[x]
path:
  v: Extension.extension.extension.value[x]
short:
  v: Length of linear sequences of amino acids contained in the subunit
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.length from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Extension.value[x]
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: integer
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: Extension.extension:subunit.extension:sequenceAttachment
path:
  v: Extension.extension.extension
slice name:
  v: sequenceAttachment
short:
  v: The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.sequenceAttachment from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  xpath:
    v: exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false

id:
  v: Extension.extension:subunit.extension:sequenceAttachment.id
path:
  v: Extension.extension.extension.id
representation:
  v: xmlAttr
short:
  v: Unique id for inter-element referencing
definition:
  v: Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Element.id
  min:
    v: 0
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
    value: url
      v: id
  code:
    v: http://hl7.org/fhirpath/System.String
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: Extension.extension:subunit.extension:sequenceAttachment.extension
path:
  v: Extension.extension.extension.extension
slicing:
  discriminator:
    type:
      v: value
    path:
      v: url
  description:
    v: Extensions are always sliced by (at least) url
  rules:
    v: open
short:
  v: Additional content defined by implementations
definition:
  v: May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
comment:
  v: There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
alias:
  v: extensions
alias:
  v: user content
min:
  v: 0
max:
  v: *
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  xpath:
    v: exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: Extension.extension:subunit.extension:sequenceAttachment.url
path:
  v: Extension.extension.extension.url
representation:
  v: xmlAttr
short:
  v: identifies the meaning of the extension
definition:
  v: Source of the definition for the extension code - a logical name or a URL.
comment:
  v: The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
min:
  v: 1
max:
  v: 1
base:
  path:
    v: Extension.url
  min:
    v: 1
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
    value: url
      v: uri
  code:
    v: http://hl7.org/fhirpath/System.String
fixed: uri
  v: sequenceAttachment
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: Extension.extension:subunit.extension:sequenceAttachment.value[x]
path:
  v: Extension.extension.extension.value[x]
short:
  v: The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.sequenceAttachment from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Extension.value[x]
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: Attachment
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: Extension.extension:subunit.extension:nTerminalModificationId
path:
  v: Extension.extension.extension
slice name:
  v: nTerminalModificationId
short:
  v: Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.nTerminalModificationId from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  xpath:
    v: exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false

id:
  v: Extension.extension:subunit.extension:nTerminalModificationId.id
path:
  v: Extension.extension.extension.id
representation:
  v: xmlAttr
short:
  v: Unique id for inter-element referencing
definition:
  v: Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Element.id
  min:
    v: 0
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
    value: url
      v: id
  code:
    v: http://hl7.org/fhirpath/System.String
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: Extension.extension:subunit.extension:nTerminalModificationId.extension
path:
  v: Extension.extension.extension.extension
slicing:
  discriminator:
    type:
      v: value
    path:
      v: url
  description:
    v: Extensions are always sliced by (at least) url
  rules:
    v: open
short:
  v: Additional content defined by implementations
definition:
  v: May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
comment:
  v: There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
alias:
  v: extensions
alias:
  v: user content
min:
  v: 0
max:
  v: *
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  xpath:
    v: exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: Extension.extension:subunit.extension:nTerminalModificationId.url
path:
  v: Extension.extension.extension.url
representation:
  v: xmlAttr
short:
  v: identifies the meaning of the extension
definition:
  v: Source of the definition for the extension code - a logical name or a URL.
comment:
  v: The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
min:
  v: 1
max:
  v: 1
base:
  path:
    v: Extension.url
  min:
    v: 1
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
    value: url
      v: uri
  code:
    v: http://hl7.org/fhirpath/System.String
fixed: uri
  v: nTerminalModificationId
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: Extension.extension:subunit.extension:nTerminalModificationId.value[x]
path:
  v: Extension.extension.extension.value[x]
short:
  v: Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.nTerminalModificationId from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Extension.value[x]
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: Identifier
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: Extension.extension:subunit.extension:nTerminalModification
path:
  v: Extension.extension.extension
slice name:
  v: nTerminalModification
short:
  v: The name of the fragment modified at the N-terminal of the SubstanceProtein shall be specified
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.nTerminalModification from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  xpath:
    v: exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false

id:
  v: Extension.extension:subunit.extension:nTerminalModification.id
path:
  v: Extension.extension.extension.id
representation:
  v: xmlAttr
short:
  v: Unique id for inter-element referencing
definition:
  v: Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Element.id
  min:
    v: 0
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
    value: url
      v: id
  code:
    v: http://hl7.org/fhirpath/System.String
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: Extension.extension:subunit.extension:nTerminalModification.extension
path:
  v: Extension.extension.extension.extension
slicing:
  discriminator:
    type:
      v: value
    path:
      v: url
  description:
    v: Extensions are always sliced by (at least) url
  rules:
    v: open
short:
  v: Additional content defined by implementations
definition:
  v: May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
comment:
  v: There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
alias:
  v: extensions
alias:
  v: user content
min:
  v: 0
max:
  v: *
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  xpath:
    v: exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: Extension.extension:subunit.extension:nTerminalModification.url
path:
  v: Extension.extension.extension.url
representation:
  v: xmlAttr
short:
  v: identifies the meaning of the extension
definition:
  v: Source of the definition for the extension code - a logical name or a URL.
comment:
  v: The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
min:
  v: 1
max:
  v: 1
base:
  path:
    v: Extension.url
  min:
    v: 1
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
    value: url
      v: uri
  code:
    v: http://hl7.org/fhirpath/System.String
fixed: uri
  v: nTerminalModification
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: Extension.extension:subunit.extension:nTerminalModification.value[x]
path:
  v: Extension.extension.extension.value[x]
short:
  v: The name of the fragment modified at the N-terminal of the SubstanceProtein shall be specified
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.nTerminalModification from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Extension.value[x]
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: string
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: Extension.extension:subunit.extension:cTerminalModificationId
path:
  v: Extension.extension.extension
slice name:
  v: cTerminalModificationId
short:
  v: Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.cTerminalModificationId from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  xpath:
    v: exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false

id:
  v: Extension.extension:subunit.extension:cTerminalModificationId.id
path:
  v: Extension.extension.extension.id
representation:
  v: xmlAttr
short:
  v: Unique id for inter-element referencing
definition:
  v: Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Element.id
  min:
    v: 0
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
    value: url
      v: id
  code:
    v: http://hl7.org/fhirpath/System.String
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: Extension.extension:subunit.extension:cTerminalModificationId.extension
path:
  v: Extension.extension.extension.extension
slicing:
  discriminator:
    type:
      v: value
    path:
      v: url
  description:
    v: Extensions are always sliced by (at least) url
  rules:
    v: open
short:
  v: Additional content defined by implementations
definition:
  v: May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
comment:
  v: There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
alias:
  v: extensions
alias:
  v: user content
min:
  v: 0
max:
  v: *
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  xpath:
    v: exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: Extension.extension:subunit.extension:cTerminalModificationId.url
path:
  v: Extension.extension.extension.url
representation:
  v: xmlAttr
short:
  v: identifies the meaning of the extension
definition:
  v: Source of the definition for the extension code - a logical name or a URL.
comment:
  v: The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
min:
  v: 1
max:
  v: 1
base:
  path:
    v: Extension.url
  min:
    v: 1
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
    value: url
      v: uri
  code:
    v: http://hl7.org/fhirpath/System.String
fixed: uri
  v: cTerminalModificationId
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: Extension.extension:subunit.extension:cTerminalModificationId.value[x]
path:
  v: Extension.extension.extension.value[x]
short:
  v: Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.cTerminalModificationId from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Extension.value[x]
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: Identifier
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: Extension.extension:subunit.extension:cTerminalModification
path:
  v: Extension.extension.extension
slice name:
  v: cTerminalModification
short:
  v: The modification at the C-terminal shall be specified
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.cTerminalModification from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  xpath:
    v: exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false

id:
  v: Extension.extension:subunit.extension:cTerminalModification.id
path:
  v: Extension.extension.extension.id
representation:
  v: xmlAttr
short:
  v: Unique id for inter-element referencing
definition:
  v: Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Element.id
  min:
    v: 0
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
    value: url
      v: id
  code:
    v: http://hl7.org/fhirpath/System.String
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: Extension.extension:subunit.extension:cTerminalModification.extension
path:
  v: Extension.extension.extension.extension
slicing:
  discriminator:
    type:
      v: value
    path:
      v: url
  description:
    v: Extensions are always sliced by (at least) url
  rules:
    v: open
short:
  v: Additional content defined by implementations
definition:
  v: May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
comment:
  v: There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
alias:
  v: extensions
alias:
  v: user content
min:
  v: 0
max:
  v: *
base:
  path:
    v: Element.extension
  min:
    v: 0
  max:
    v: *
type:
  code:
    v: Extension
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
constraint:
  key:
    v: ext-1
  severity:
    v: error
  human:
    v: Must have either extensions or value[x], not both
  expression:
    v: extension.exists() != value.exists()
  xpath:
    v: exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])
  source:
    v: http://hl7.org/fhir/StructureDefinition/Extension|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: n/a

id:
  v: Extension.extension:subunit.extension:cTerminalModification.url
path:
  v: Extension.extension.extension.url
representation:
  v: xmlAttr
short:
  v: identifies the meaning of the extension
definition:
  v: Source of the definition for the extension code - a logical name or a URL.
comment:
  v: The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
min:
  v: 1
max:
  v: 1
base:
  path:
    v: Extension.url
  min:
    v: 1
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
    value: url
      v: uri
  code:
    v: http://hl7.org/fhirpath/System.String
fixed: uri
  v: cTerminalModification
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: Extension.extension:subunit.extension:cTerminalModification.value[x]
path:
  v: Extension.extension.extension.value[x]
short:
  v: The modification at the C-terminal shall be specified
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.cTerminalModification from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Extension.value[x]
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: string
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: Extension.extension:subunit.url
path:
  v: Extension.extension.url
representation:
  v: xmlAttr
short:
  v: identifies the meaning of the extension
definition:
  v: Source of the definition for the extension code - a logical name or a URL.
comment:
  v: The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
min:
  v: 1
max:
  v: 1
base:
  path:
    v: Extension.url
  min:
    v: 1
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
    value: url
      v: uri
  code:
    v: http://hl7.org/fhirpath/System.String
fixed: uri
  v: subunit
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: Extension.extension:subunit.value[x]
path:
  v: Extension.extension.value[x]
short:
  v: Value of extension
definition:
  v: Value of extension - must be one of a constrained set of the data types (see [Extensibility](http://hl7.org/fhir/R4B/extensibility.html) for a list).
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Extension.value[x]
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: base64Binary
type:
  code:
    v: boolean
type:
  code:
    v: canonical
type:
  code:
    v: code
type:
  code:
    v: date
type:
  code:
    v: dateTime
type:
  code:
    v: decimal
type:
  code:
    v: id
type:
  code:
    v: instant
type:
  code:
    v: integer
type:
  code:
    v: markdown
type:
  code:
    v: oid
type:
  code:
    v: positiveInt
type:
  code:
    v: string
type:
  code:
    v: time
type:
  code:
    v: unsignedInt
type:
  code:
    v: uri
type:
  code:
    v: url
type:
  code:
    v: uuid
type:
  code:
    v: Address
type:
  code:
    v: Age
type:
  code:
    v: Annotation
type:
  code:
    v: Attachment
type:
  code:
    v: CodeableConcept
type:
  code:
    v: CodeableReference
type:
  code:
    v: Coding
type:
  code:
    v: ContactPoint
type:
  code:
    v: Count
type:
  code:
    v: Distance
type:
  code:
    v: Duration
type:
  code:
    v: HumanName
type:
  code:
    v: Identifier
type:
  code:
    v: Money
type:
  code:
    v: Period
type:
  code:
    v: Quantity
type:
  code:
    v: Range
type:
  code:
    v: Ratio
type:
  code:
    v: RatioRange
type:
  code:
    v: Reference
type:
  code:
    v: SampledData
type:
  code:
    v: Signature
type:
  code:
    v: Timing
type:
  code:
    v: ContactDetail
type:
  code:
    v: Contributor
type:
  code:
    v: DataRequirement
type:
  code:
    v: Expression
type:
  code:
    v: ParameterDefinition
type:
  code:
    v: RelatedArtifact
type:
  code:
    v: TriggerDefinition
type:
  code:
    v: UsageContext
type:
  code:
    v: Dosage
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: Extension.url
path:
  v: Extension.url
representation:
  v: xmlAttr
short:
  v: identifies the meaning of the extension
definition:
  v: Source of the definition for the extension code - a logical name or a URL.
comment:
  v: The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
min:
  v: 1
max:
  v: 1
base:
  path:
    v: Extension.url
  min:
    v: 1
  max:
    v: 1
type:
  extension:
    url:
      v: http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type
    value: url
      v: uri
  code:
    v: http://hl7.org/fhirpath/System.String
fixed: uri
  v: http://hl7.org/fhir/4.0/StructureDefinition/extension-SubstanceProtein
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

id:
  v: Extension.value[x]
path:
  v: Extension.value[x]
short:
  v: Value of extension
definition:
  v: Value of extension - must be one of a constrained set of the data types (see [Extensibility](http://hl7.org/fhir/R4B/extensibility.html) for a list).
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Extension.value[x]
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: base64Binary
type:
  code:
    v: boolean
type:
  code:
    v: canonical
type:
  code:
    v: code
type:
  code:
    v: date
type:
  code:
    v: dateTime
type:
  code:
    v: decimal
type:
  code:
    v: id
type:
  code:
    v: instant
type:
  code:
    v: integer
type:
  code:
    v: markdown
type:
  code:
    v: oid
type:
  code:
    v: positiveInt
type:
  code:
    v: string
type:
  code:
    v: time
type:
  code:
    v: unsignedInt
type:
  code:
    v: uri
type:
  code:
    v: url
type:
  code:
    v: uuid
type:
  code:
    v: Address
type:
  code:
    v: Age
type:
  code:
    v: Annotation
type:
  code:
    v: Attachment
type:
  code:
    v: CodeableConcept
type:
  code:
    v: CodeableReference
type:
  code:
    v: Coding
type:
  code:
    v: ContactPoint
type:
  code:
    v: Count
type:
  code:
    v: Distance
type:
  code:
    v: Duration
type:
  code:
    v: HumanName
type:
  code:
    v: Identifier
type:
  code:
    v: Money
type:
  code:
    v: Period
type:
  code:
    v: Quantity
type:
  code:
    v: Range
type:
  code:
    v: Ratio
type:
  code:
    v: RatioRange
type:
  code:
    v: Reference
type:
  code:
    v: SampledData
type:
  code:
    v: Signature
type:
  code:
    v: Timing
type:
  code:
    v: ContactDetail
type:
  code:
    v: Contributor
type:
  code:
    v: DataRequirement
type:
  code:
    v: Expression
type:
  code:
    v: ParameterDefinition
type:
  code:
    v: RelatedArtifact
type:
  code:
    v: TriggerDefinition
type:
  code:
    v: UsageContext
type:
  code:
    v: Dosage
constraint:
  key:
    v: ele-1
  severity:
    v: error
  human:
    v: All FHIR elements must have a @value or children
  expression:
    v: hasValue() or (children().count() > id.count())
  xpath:
    v: @value|f:*|h:div
  source:
    v: http://hl7.org/fhir/StructureDefinition/Element|4.3.0
    link: 4.3
    link: .0
is modifier:
  v: false
is summary:
  v: false
mapping:
  identity:
    v: rim
  map:
    v: N/A

element:
  id:
    v: Extension
  path:
    v: Extension
  short:
    v: A SubstanceProtein is defined as a single unit of a linear amino acid sequence, or a combination of subunits that are either covalently linked or have a defined invariant stoichiometric relationship. This includes all synthetic, recombinant and purified SubstanceProteins of defined sequence, whether the use is therapeutic or prophylactic. This set of elements will be used to describe albumins, coagulation factors, cytokines, growth factors, peptide/SubstanceProtein hormones, enzymes, toxins, toxoids, recombinant vaccines, and immunomodulators
  definition:
    v: This cross-version extension represents SubstanceProtein from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
  min:
    v: 0
  max:
    v: *
  base:
    path:
      v: Extension
    min:
      v: 0
    max:
      v: *
element:
  id:
    v: Extension.extension
  path:
    v: Extension.extension
  slicing:
    discriminator:
      type:
        v: value
      path:
        v: url
    ordered:
      v: false
    rules:
      v: closed
  min:
    v: 0
  max:
    v: *
  base:
    path:
      v: Extension.extension
    min:
      v: 0
    max:
      v: *
element:
  id:
    v: Extension.extension:sequenceType
  path:
    v: Extension.extension
  slice name:
    v: sequenceType
  short:
    v: The SubstanceProtein descriptive elements will only be used when a complete or partial amino acid sequence is available or derivable from a nucleic acid sequence
  definition:
    v: This cross-version extension represents SubstanceProtein.sequenceType from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
  min:
    v: 0
  max:
    v: 1
  base:
    path:
      v: Extension.extension
    min:
      v: 0
    max:
      v: *
element:
  id:
    v: Extension.extension:sequenceType.url
  path:
    v: Extension.extension.url
  min:
    v: 1
  max:
    v: 1
  base:
    path:
      v: Extension.url
    min:
      v: 1
    max:
      v: 1
  fixed: uri
    v: sequenceType
element:
  id:
    v: Extension.extension:sequenceType.value[x]
  path:
    v: Extension.extension.value[x]
  short:
    v: The SubstanceProtein descriptive elements will only be used when a complete or partial amino acid sequence is available or derivable from a nucleic acid sequence
  definition:
    v: This cross-version extension represents SubstanceProtein.sequenceType from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
  base:
    path:
      v: Extension.value[x]
    min:
      v: 0
    max:
      v: 1
  type:
    code:
      v: CodeableConcept
element:
  id:
    v: Extension.extension:numberOfSubunits
  path:
    v: Extension.extension
  slice name:
    v: numberOfSubunits
  short:
    v: Number of linear sequences of amino acids linked through peptide bonds. The number of subunits constituting the SubstanceProtein shall be described. It is possible that the number of subunits can be variable
  definition:
    v: This cross-version extension represents SubstanceProtein.numberOfSubunits from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
  min:
    v: 0
  max:
    v: 1
  base:
    path:
      v: Extension.extension
    min:
      v: 0
    max:
      v: *
element:
  id:
    v: Extension.extension:numberOfSubunits.url
  path:
    v: Extension.extension.url
  min:
    v: 1
  max:
    v: 1
  base:
    path:
      v: Extension.url
    min:
      v: 1
    max:
      v: 1
  fixed: uri
    v: numberOfSubunits
element:
  id:
    v: Extension.extension:numberOfSubunits.value[x]
  path:
    v: Extension.extension.value[x]
  short:
    v: Number of linear sequences of amino acids linked through peptide bonds. The number of subunits constituting the SubstanceProtein shall be described. It is possible that the number of subunits can be variable
  definition:
    v: This cross-version extension represents SubstanceProtein.numberOfSubunits from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
  base:
    path:
      v: Extension.value[x]
    min:
      v: 0
    max:
      v: 1
  type:
    code:
      v: integer
element:
  id:
    v: Extension.extension:disulfideLinkage
  path:
    v: Extension.extension
  slice name:
    v: disulfideLinkage
  short:
    v: The disulphide bond between two cysteine residues either on the same subunit or on two different subunits shall be described. The position of the disulfide bonds in the SubstanceProtein shall be listed in increasing order of subunit number and position within subunit followed by the abbreviation of the amino acids involved. The disulfide linkage positions shall actually contain the amino acid Cysteine at the respective positions
  definition:
    v: This cross-version extension represents SubstanceProtein.disulfideLinkage from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
  min:
    v: 0
  max:
    v: *
  base:
    path:
      v: Extension.extension
    min:
      v: 0
    max:
      v: *
element:
  id:
    v: Extension.extension:disulfideLinkage.url
  path:
    v: Extension.extension.url
  min:
    v: 1
  max:
    v: 1
  base:
    path:
      v: Extension.url
    min:
      v: 1
    max:
      v: 1
  fixed: uri

uri
v: disulfideLinkage

id:
  v: Extension.extension:disulfideLinkage.value[x]
path:
  v: Extension.extension.value[x]
short:
  v: The disulphide bond between two cysteine residues either on the same subunit or on two different subunits shall be described. The position of the disulfide bonds in the SubstanceProtein shall be listed in increasing order of subunit number and position within subunit followed by the abbreviation of the amino acids involved. The disulfide linkage positions shall actually contain the amino acid Cysteine at the respective positions
definition:
  v: This cross-version extension represents SubstanceProtein.disulfideLinkage from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
base:
  path:
    v: Extension.value[x]
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: string

id:
  v: Extension.extension:subunit
path:
  v: Extension.extension
slice name:
  v: subunit
short:
  v: This subclause refers to the description of each subunit constituting the SubstanceProtein. A subunit is a linear sequence of amino acids linked through peptide bonds. The Subunit information shall be provided when the finished SubstanceProtein is a complex of multiple sequences; subunits are not used to delineate domains within a single sequence. Subunits are listed in order of decreasing length; sequences of the same length will be ordered by decreasing molecular weight; subunits that have identical sequences will be repeated multiple times
definition:
  v: This cross-version extension represents SubstanceProtein.subunit from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: *
base:
  path:
    v: Extension.extension
  min:
    v: 0
  max:
    v: *

id:
  v: Extension.extension:subunit.extension
path:
  v: Extension.extension.extension
slicing:
  discriminator:
    type:
      v: value
    path:
      v: url
  ordered:
    v: false
  rules:
    v: closed
min:
  v: 0
max:
  v: *
base:
  path:
    v: Extension.extension
  min:
    v: 0
  max:
    v: *

id:
  v: Extension.extension:subunit.extension:subunit
path:
  v: Extension.extension.extension
slice name:
  v: subunit
short:
  v: Index of primary sequences of amino acids linked through peptide bonds in order of decreasing length. Sequences of the same length will be ordered by molecular weight. Subunits that have identical sequences will be repeated and have sequential subscripts
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.subunit from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Extension.extension
  min:
    v: 0
  max:
    v: *

id:
  v: Extension.extension:subunit.extension:subunit.url
path:
  v: Extension.extension.extension.url
min:
  v: 1
max:
  v: 1
base:
  path:
    v: Extension.url
  min:
    v: 1
  max:
    v: 1
fixed: uri
  v: subunit

id:
  v: Extension.extension:subunit.extension:subunit.value[x]
path:
  v: Extension.extension.extension.value[x]
short:
  v: Index of primary sequences of amino acids linked through peptide bonds in order of decreasing length. Sequences of the same length will be ordered by molecular weight. Subunits that have identical sequences will be repeated and have sequential subscripts
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.subunit from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
base:
  path:
    v: Extension.value[x]
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: integer

id:
  v: Extension.extension:subunit.extension:sequence
path:
  v: Extension.extension.extension
slice name:
  v: sequence
short:
  v: The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.sequence from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Extension.extension
  min:
    v: 0
  max:
    v: *

id:
  v: Extension.extension:subunit.extension:sequence.url
path:
  v: Extension.extension.extension.url
min:
  v: 1
max:
  v: 1
base:
  path:
    v: Extension.url
  min:
    v: 1
  max:
    v: 1
fixed: uri
  v: sequence

id:
  v: Extension.extension:subunit.extension:sequence.value[x]
path:
  v: Extension.extension.extension.value[x]
short:
  v: The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.sequence from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
base:
  path:
    v: Extension.value[x]
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: string

id:
  v: Extension.extension:subunit.extension:length
path:
  v: Extension.extension.extension
slice name:
  v: length
short:
  v: Length of linear sequences of amino acids contained in the subunit
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.length from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Extension.extension
  min:
    v: 0
  max:
    v: *

id:
  v: Extension.extension:subunit.extension:length.url
path:
  v: Extension.extension.extension.url
min:
  v: 1
max:
  v: 1
base:
  path:
    v: Extension.url
  min:
    v: 1
  max:
    v: 1
fixed: uri
  v: length

id:
  v: Extension.extension:subunit.extension:length.value[x]
path:
  v: Extension.extension.extension.value[x]
short:
  v: Length of linear sequences of amino acids contained in the subunit
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.length from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
base:
  path:
    v: Extension.value[x]
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: integer

id:
  v: Extension.extension:subunit.extension:sequenceAttachment
path:
  v: Extension.extension.extension
slice name:
  v: sequenceAttachment
short:
  v: The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.sequenceAttachment from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Extension.extension
  min:
    v: 0
  max:
    v: *

id:
  v: Extension.extension:subunit.extension:sequenceAttachment.url
path:
  v: Extension.extension.extension.url
min:
  v: 1
max:
  v: 1
base:
  path:
    v: Extension.url
  min:
    v: 1
  max:
    v: 1
fixed: uri
  v: sequenceAttachment

id:
  v: Extension.extension:subunit.extension:sequenceAttachment.value[x]
path:
  v: Extension.extension.extension.value[x]
short:
  v: The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.sequenceAttachment from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
base:
  path:
    v: Extension.value[x]
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: Attachment

id:
  v: Extension.extension:subunit.extension:nTerminalModificationId
path:
  v: Extension.extension.extension
slice name:
  v: nTerminalModificationId
short:
  v: Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.nTerminalModificationId from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Extension.extension
  min:
    v: 0
  max:
    v: *

id:
  v: Extension.extension:subunit.extension:nTerminalModificationId.url
path:
  v: Extension.extension.extension.url
min:
  v: 1
max:
  v: 1
base:
  path:
    v: Extension.url
  min:
    v: 1
  max:
    v: 1
fixed: uri
  v: nTerminalModificationId

id:
  v: Extension.extension:subunit.extension:nTerminalModificationId.value[x]
path:
  v: Extension.extension.extension.value[x]
short:
  v: Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.nTerminalModificationId from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
base:
  path:
    v: Extension.value[x]
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: Identifier

id:
  v: Extension.extension:subunit.extension:nTerminalModification
path:
  v: Extension.extension.extension
slice name:
  v: nTerminalModification
short:
  v: The name of the fragment modified at the N-terminal of the SubstanceProtein shall be specified
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.nTerminalModification from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Extension.extension
  min:
    v: 0
  max:
    v: *

id:
  v: Extension.extension:subunit.extension:nTerminalModification.url
path:
  v: Extension.extension.extension.url
min:
  v: 1
max:
  v: 1
base:
  path:
    v: Extension.url
  min:
    v: 1
  max:
    v: 1
fixed: uri
  v: nTerminalModification

id:
  v: Extension.extension:subunit.extension:nTerminalModification.value[x]
path:
  v: Extension.extension.extension.value[x]
short:
  v: The name of the fragment modified at the N-terminal of the SubstanceProtein shall be specified
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.nTerminalModification from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
base:
  path:
    v: Extension.value[x]
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: string

id:
  v: Extension.extension:subunit.extension:cTerminalModificationId
path:
  v: Extension.extension.extension
slice name:
  v: cTerminalModificationId
short:
  v: Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.cTerminalModificationId from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Extension.extension
  min:
    v: 0
  max:
    v: *

id:
  v: Extension.extension:subunit.extension:cTerminalModificationId.url
path:
  v: Extension.extension.extension.url
min:
  v: 1
max:
  v: 1
base:
  path:
    v: Extension.url
  min:
    v: 1
  max:
    v: 1
fixed: uri
  v: cTerminalModificationId

id:
  v: Extension.extension:subunit.extension:cTerminalModificationId.value[x]
path:
  v: Extension.extension.extension.value[x]
short:
  v: Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.cTerminalModificationId from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
base:
  path:
    v: Extension.value[x]
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: Identifier

id:
  v: Extension.extension:subunit.extension:cTerminalModification
path:
  v: Extension.extension.extension
slice name:
  v: cTerminalModification
short:
  v: The modification at the C-terminal shall be specified
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.cTerminalModification from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
min:
  v: 0
max:
  v: 1
base:
  path:
    v: Extension.extension
  min:
    v: 0
  max:
    v: *

id:
  v: Extension.extension:subunit.extension:cTerminalModification.url
path:
  v: Extension.extension.extension.url
min:
  v: 1
max:
  v: 1
base:
  path:
    v: Extension.url
  min:
    v: 1
  max:
    v: 1
fixed: uri
  v: cTerminalModification

id:
  v: Extension.extension:subunit.extension:cTerminalModification.value[x]
path:
  v: Extension.extension.extension.value[x]
short:
  v: The modification at the C-terminal shall be specified
definition:
  v: This cross-version extension represents SubstanceProtein.subunit.cTerminalModification from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
base:
  path:
    v: Extension.value[x]
  min:
    v: 0
  max:
    v: 1
type:
  code:
    v: string

id:
  v: Extension.extension:subunit.url
path:
  v: Extension.extension.url
min:
  v: 1
max:
  v: 1
base:
  path:
    v: Extension.url
  min:
    v: 1
  max:
    v: 1
fixed: uri
  v: subunit

id:
  v: Extension.url
path:
  v: Extension.url
min:
  v: 1
max:
  v: 1
base:
  path:
    v: Extension.url
  min:
    v: 1
  max:
    v: 1
fixed: uri
  v: http://hl7.org/fhir/4.0/StructureDefinition/extension-SubstanceProtein