Generated Narrative: StructureDefinition ext-R4-SubstanceProtein Name Flags Card. Type Description & Constraints Extension 0..* Extension(4.3.0) A SubstanceProtein is defined as a single unit of a linear amino acid sequence, or a combination of subunits that are either covalently linked or have a defined invariant stoichiometric relationship. This includes all synthetic, recombinant and purified SubstanceProteins of defined sequence, whether the use is therapeutic or prophylactic. This set of elements will be used to describe albumins, coagulation factors, cytokines, growth factors, peptide/SubstanceProtein hormones, enzymes, toxins, toxoids, recombinant vaccines, and immunomodulators #xD; Slices for extension 0..* Extension Extension Slice: Unordered, Closed by value:url #xD; extension:sequenceType 0..1 Extension The SubstanceProtein descriptive elements will only be used when a complete or partial amino acid sequence is available or derivable from a nucleic acid sequence #xD; url 1..1 uri "sequenceType" #xD; value[x] 0..1 CodeableConcept The SubstanceProtein descriptive elements will only be used when a complete or partial amino acid sequence is available or derivable from a nucleic acid sequence #xD; extension:numberOfSubunits 0..1 Extension Number of linear sequences of amino acids linked through peptide bonds. The number of subunits constituting the SubstanceProtein shall be described. It is possible that the number of subunits can be variable #xD; url 1..1 uri "numberOfSubunits" #xD; value[x] 0..1 integer Number of linear sequences of amino acids linked through peptide bonds. The number of subunits constituting the SubstanceProtein shall be described. It is possible that the number of subunits can be variable #xD; extension:disulfideLinkage 0..* Extension The disulphide bond between two cysteine residues either on the same subunit or on two different subunits shall be described. The position of the disulfide bonds in the SubstanceProtein shall be listed in increasing order of subunit number and position within subunit followed by the abbreviation of the amino acids involved. The disulfide linkage positions shall actually contain the amino acid Cysteine at the respective positions #xD; url 1..1 uri "disulfideLinkage" #xD; value[x] 0..1 string The disulphide bond between two cysteine residues either on the same subunit or on two different subunits shall be described. The position of the disulfide bonds in the SubstanceProtein shall be listed in increasing order of subunit number and position within subunit followed by the abbreviation of the amino acids involved. The disulfide linkage positions shall actually contain the amino acid Cysteine at the respective positions #xD; extension:subunit 0..* Extension This subclause refers to the description of each subunit constituting the SubstanceProtein. A subunit is a linear sequence of amino acids linked through peptide bonds. The Subunit information shall be provided when the finished SubstanceProtein is a complex of multiple sequences; subunits are not used to delineate domains within a single sequence. Subunits are listed in order of decreasing length; sequences of the same length will be ordered by decreasing molecular weight; subunits that have identical sequences will be repeated multiple times #xD; Slices for extension 0..* Extension Extension Slice: Unordered, Closed by value:url #xD; extension:subunit 0..1 Extension Index of primary sequences of amino acids linked through peptide bonds in order of decreasing length. Sequences of the same length will be ordered by molecular weight. Subunits that have identical sequences will be repeated and have sequential subscripts #xD; url 1..1 uri "subunit" #xD; value[x] 0..1 integer Index of primary sequences of amino acids linked through peptide bonds in order of decreasing length. Sequences of the same length will be ordered by molecular weight. Subunits that have identical sequences will be repeated and have sequential subscripts #xD; extension:sequence 0..1 Extension The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence #xD; url 1..1 uri "sequence" #xD; value[x] 0..1 string The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence #xD; extension:length 0..1 Extension Length of linear sequences of amino acids contained in the subunit #xD; url 1..1 uri "length" #xD; value[x] 0..1 integer Length of linear sequences of amino acids contained in the subunit #xD; extension:sequenceAttachment 0..1 Extension The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence #xD; url 1..1 uri "sequenceAttachment" #xD; value[x] 0..1 Attachment The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence #xD; extension:nTerminalModificationId 0..1 Extension Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID #xD; url 1..1 uri "nTerminalModificationId" #xD; value[x] 0..1 Identifier Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID #xD; extension:nTerminalModification 0..1 Extension The name of the fragment modified at the N-terminal of the SubstanceProtein shall be specified #xD; url 1..1 uri "nTerminalModification" #xD; value[x] 0..1 string The name of the fragment modified at the N-terminal of the SubstanceProtein shall be specified #xD; extension:cTerminalModificationId 0..1 Extension Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID #xD; url 1..1 uri "cTerminalModificationId" #xD; value[x] 0..1 Identifier Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID #xD; extension:cTerminalModification 0..1 Extension The modification at the C-terminal shall be specified #xD; url 1..1 uri "cTerminalModification" #xD; value[x] 0..1 string The modification at the C-terminal shall be specified #xD; url 1..1 uri "subunit" #xD; url 1..1 uri "http://hl7.org/fhir/4.0/StructureDefinition/extension-SubstanceProtein" #xD; Documentation for this format
Cross-version Extension for R4.SubstanceProtein for use in FHIR R4B
This cross-version extension represents SubstanceProtein from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
A SubstanceProtein is defined as a single unit of a linear amino acid sequence, or a combination of subunits that are either covalently linked or have a defined invariant stoichiometric relationship. This includes all synthetic, recombinant and purified SubstanceProteins of defined sequence, whether the use is therapeutic or prophylactic. This set of elements will be used to describe albumins, coagulation factors, cytokines, growth factors, peptide/SubstanceProtein hormones, enzymes, toxins, toxoids, recombinant vaccines, and immunomodulators
All FHIR elements must have a @value or children unless an empty Parameters resource
hasValue() or (children().count() > id.count()) or $this is Parameters
Must have either extensions or value[x], not both
exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])
Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Extensions are always sliced by (at least) url
All FHIR elements must have a @value or children
hasValue() or (children().count() > id.count())
exists(f:extension)!=exists(f:*[starts-with(local-name(.), "value")])
The SubstanceProtein descriptive elements will only be used when a complete or partial amino acid sequence is available or derivable from a nucleic acid sequence
This cross-version extension represents SubstanceProtein.sequenceType from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
Additional content defined by implementations
May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Source of the definition for the extension code - a logical name or a URL.
The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Number of linear sequences of amino acids linked through peptide bonds. The number of subunits constituting the SubstanceProtein shall be described. It is possible that the number of subunits can be variable
This cross-version extension represents SubstanceProtein.numberOfSubunits from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
The disulphide bond between two cysteine residues either on the same subunit or on two different subunits shall be described. The position of the disulfide bonds in the SubstanceProtein shall be listed in increasing order of subunit number and position within subunit followed by the abbreviation of the amino acids involved. The disulfide linkage positions shall actually contain the amino acid Cysteine at the respective positions
This cross-version extension represents SubstanceProtein.disulfideLinkage from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
This subclause refers to the description of each subunit constituting the SubstanceProtein. A subunit is a linear sequence of amino acids linked through peptide bonds. The Subunit information shall be provided when the finished SubstanceProtein is a complex of multiple sequences; subunits are not used to delineate domains within a single sequence. Subunits are listed in order of decreasing length; sequences of the same length will be ordered by decreasing molecular weight; subunits that have identical sequences will be repeated multiple times
This cross-version extension represents SubstanceProtein.subunit from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
Index of primary sequences of amino acids linked through peptide bonds in order of decreasing length. Sequences of the same length will be ordered by molecular weight. Subunits that have identical sequences will be repeated and have sequential subscripts
This cross-version extension represents SubstanceProtein.subunit.subunit from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence
This cross-version extension represents SubstanceProtein.subunit.sequence from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
Length of linear sequences of amino acids contained in the subunit
This cross-version extension represents SubstanceProtein.subunit.length from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
This cross-version extension represents SubstanceProtein.subunit.sequenceAttachment from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID
This cross-version extension represents SubstanceProtein.subunit.nTerminalModificationId from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
The name of the fragment modified at the N-terminal of the SubstanceProtein shall be specified
This cross-version extension represents SubstanceProtein.subunit.nTerminalModification from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
This cross-version extension represents SubstanceProtein.subunit.cTerminalModificationId from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
The modification at the C-terminal shall be specified
This cross-version extension represents SubstanceProtein.subunit.cTerminalModification from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
Value of extension - must be one of a constrained set of the data types (see [Extensibility](http://hl7.org/fhir/R4B/extensibility.html) for a list).