FHIR Cross-Version Extensions package for FHIR R4B from FHIR R4
0.0.1-snapshot-2 - informative
FHIR Cross-Version Extensions package for FHIR R4B from FHIR R4
0.0.1-snapshot-2 - informative
FHIR Cross-Version Extensions package for FHIR R4B from FHIR R4 - Version 0.0.1-snapshot-2. See the Directory of published versions
| Official URL: http://hl7.org/fhir/4.0/StructureDefinition/extension-SubstanceProtein | Version: 0.0.1-snapshot-2 | |||
| Standards status: Informative | Maturity Level: 0 | Computable Name: Ext_R4_SubstanceProtein | ||
| This cross-version extension represents SubstanceProtein from http://hl7.org/fhir/StructureDefinition/SubstanceProtein | 4.0.1 for use in FHIR R4B. |
Context of Use
This extension may be used on the following element(s):
Usage info
Usages:
You can also check for usages in the FHIR IG Statistics
Description of Profiles, Differentials, Snapshots, and how the XML and JSON presentations work.
This structure is derived from Extension
Summary
Simple Extension with the type base64Binary, boolean, canonical, code, date, dateTime, decimal, id, instant, integer, markdown, oid, positiveInt, string, time, unsignedInt, uri, url, uuid, Address, Age, Annotation, Attachment, CodeableConcept, CodeableReference, Coding, ContactPoint, Count, Distance, Duration, HumanName, Identifier, Money, Period, Quantity, Range, Ratio, RatioRange, Reference, SampledData, Signature, Timing, ContactDetail, Contributor, DataRequirement, Expression, ParameterDefinition, RelatedArtifact, TriggerDefinition, UsageContext, Dosage: This cross-version extension represents SubstanceProtein from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
Maturity: 0
This structure is derived from Extension
| Name | Flags | Card. | Type | Description & Constraints Filter:   |
|---|---|---|---|---|
  Extension |
0..* | Extension(4.3.0) | A SubstanceProtein is defined as a single unit of a linear amino acid sequence, or a combination of subunits that are either covalently linked or have a defined invariant stoichiometric relationship. This includes all synthetic, recombinant and purified SubstanceProteins of defined sequence, whether the use is therapeutic or prophylactic. This set of elements will be used to describe albumins, coagulation factors, cytokines, growth factors, peptide/SubstanceProtein hormones, enzymes, toxins, toxoids, recombinant vaccines, and immunomodulators | |
  Slices for extension |
0..* | Extension | Extension Slice: Unordered, Closed by value:url | |
   extension:sequenceType |
0..1 | Extension | The SubstanceProtein descriptive elements will only be used when a complete or partial amino acid sequence is available or derivable from a nucleic acid sequence | |
  url |
1..1 | uri | "sequenceType" | |
  value[x] |
0..1 | CodeableConcept | The SubstanceProtein descriptive elements will only be used when a complete or partial amino acid sequence is available or derivable from a nucleic acid sequence | |
| extension:numberOfSubunits |
0..1 | Extension | Number of linear sequences of amino acids linked through peptide bonds. The number of subunits constituting the SubstanceProtein shall be described. It is possible that the number of subunits can be variable | |
| url |
1..1 | uri | "numberOfSubunits" | |
 value[x] |
0..1 | integer | Number of linear sequences of amino acids linked through peptide bonds. The number of subunits constituting the SubstanceProtein shall be described. It is possible that the number of subunits can be variable | |
| extension:disulfideLinkage |
0..* | Extension | The disulphide bond between two cysteine residues either on the same subunit or on two different subunits shall be described. The position of the disulfide bonds in the SubstanceProtein shall be listed in increasing order of subunit number and position within subunit followed by the abbreviation of the amino acids involved. The disulfide linkage positions shall actually contain the amino acid Cysteine at the respective positions | |
| url |
1..1 | uri | "disulfideLinkage" | |
| value[x] |
0..1 | string | The disulphide bond between two cysteine residues either on the same subunit or on two different subunits shall be described. The position of the disulfide bonds in the SubstanceProtein shall be listed in increasing order of subunit number and position within subunit followed by the abbreviation of the amino acids involved. The disulfide linkage positions shall actually contain the amino acid Cysteine at the respective positions | |
 extension:subunit |
0..* | Extension | This subclause refers to the description of each subunit constituting the SubstanceProtein. A subunit is a linear sequence of amino acids linked through peptide bonds. The Subunit information shall be provided when the finished SubstanceProtein is a complex of multiple sequences; subunits are not used to delineate domains within a single sequence. Subunits are listed in order of decreasing length; sequences of the same length will be ordered by decreasing molecular weight; subunits that have identical sequences will be repeated multiple times | |
  Slices for extension |
0..* | Extension | Extension Slice: Unordered, Closed by value:url | |
 extension:subunit |
0..1 | Extension | Index of primary sequences of amino acids linked through peptide bonds in order of decreasing length. Sequences of the same length will be ordered by molecular weight. Subunits that have identical sequences will be repeated and have sequential subscripts | |
| url |
1..1 | uri | "subunit" | |
| value[x] |
0..1 | integer | Index of primary sequences of amino acids linked through peptide bonds in order of decreasing length. Sequences of the same length will be ordered by molecular weight. Subunits that have identical sequences will be repeated and have sequential subscripts | |
| extension:sequence |
0..1 | Extension | The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence | |
| url |
1..1 | uri | "sequence" | |
| value[x] |
0..1 | string | The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence | |
| extension:length |
0..1 | Extension | Length of linear sequences of amino acids contained in the subunit | |
| url |
1..1 | uri | "length" | |
| value[x] |
0..1 | integer | Length of linear sequences of amino acids contained in the subunit | |
| extension:sequenceAttachment |
0..1 | Extension | The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence | |
| url |
1..1 | uri | "sequenceAttachment" | |
| value[x] |
0..1 | Attachment | The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence | |
| extension:nTerminalModificationId |
0..1 | Extension | Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID | |
| url |
1..1 | uri | "nTerminalModificationId" | |
| value[x] |
0..1 | Identifier | Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID | |
| extension:nTerminalModification |
0..1 | Extension | The name of the fragment modified at the N-terminal of the SubstanceProtein shall be specified | |
| url |
1..1 | uri | "nTerminalModification" | |
| value[x] |
0..1 | string | The name of the fragment modified at the N-terminal of the SubstanceProtein shall be specified | |
| extension:cTerminalModificationId |
0..1 | Extension | Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID | |
| url |
1..1 | uri | "cTerminalModificationId" | |
| value[x] |
0..1 | Identifier | Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID | |
| extension:cTerminalModification |
0..1 | Extension | The modification at the C-terminal shall be specified | |
| url |
1..1 | uri | "cTerminalModification" | |
| value[x] |
0..1 | string | The modification at the C-terminal shall be specified | |
| url |
1..1 | uri | "subunit" | |
 url |
1..1 | uri | "http://hl7.org/fhir/4.0/StructureDefinition/extension-SubstanceProtein" | |
| Documentation for this format | ||||
| Name | Flags | Card. | Type | Description & Constraints Filter: |
|---|---|---|---|---|
| Extension |
0..* | Extension(4.3.0) | A SubstanceProtein is defined as a single unit of a linear amino acid sequence, or a combination of subunits that are either covalently linked or have a defined invariant stoichiometric relationship. This includes all synthetic, recombinant and purified SubstanceProteins of defined sequence, whether the use is therapeutic or prophylactic. This set of elements will be used to describe albumins, coagulation factors, cytokines, growth factors, peptide/SubstanceProtein hormones, enzymes, toxins, toxoids, recombinant vaccines, and immunomodulators Constraints: ext-1 | |
 id |
0..1 | id | Unique id for inter-element referencing | |
| Slices for extension |
0..* | Extension | Extension Slice: Unordered, Closed by value:url Constraints: ext-1 | |
| extension:sequenceType |
0..1 | Extension | The SubstanceProtein descriptive elements will only be used when a complete or partial amino acid sequence is available or derivable from a nucleic acid sequence Constraints: ext-1 | |
| id |
0..1 | id | Unique id for inter-element referencing | |
 extension |
0..* | Extension | Additional content defined by implementations Slice: Unordered, Open by value:url Constraints: ext-1 | |
| url |
1..1 | uri | "sequenceType" | |
| value[x] |
0..1 | CodeableConcept | The SubstanceProtein descriptive elements will only be used when a complete or partial amino acid sequence is available or derivable from a nucleic acid sequence | |
| extension:numberOfSubunits |
0..1 | Extension | Number of linear sequences of amino acids linked through peptide bonds. The number of subunits constituting the SubstanceProtein shall be described. It is possible that the number of subunits can be variable Constraints: ext-1 | |
| id |
0..1 | id | Unique id for inter-element referencing | |
| extension |
0..* | Extension | Additional content defined by implementations Slice: Unordered, Open by value:url Constraints: ext-1 | |
| url |
1..1 | uri | "numberOfSubunits" | |
| value[x] |
0..1 | integer | Number of linear sequences of amino acids linked through peptide bonds. The number of subunits constituting the SubstanceProtein shall be described. It is possible that the number of subunits can be variable | |
| extension:disulfideLinkage |
0..* | Extension | The disulphide bond between two cysteine residues either on the same subunit or on two different subunits shall be described. The position of the disulfide bonds in the SubstanceProtein shall be listed in increasing order of subunit number and position within subunit followed by the abbreviation of the amino acids involved. The disulfide linkage positions shall actually contain the amino acid Cysteine at the respective positions Constraints: ext-1 | |
| id |
0..1 | id | Unique id for inter-element referencing | |
| extension |
0..* | Extension | Additional content defined by implementations Slice: Unordered, Open by value:url Constraints: ext-1 | |
| url |
1..1 | uri | "disulfideLinkage" | |
| value[x] |
0..1 | string | The disulphide bond between two cysteine residues either on the same subunit or on two different subunits shall be described. The position of the disulfide bonds in the SubstanceProtein shall be listed in increasing order of subunit number and position within subunit followed by the abbreviation of the amino acids involved. The disulfide linkage positions shall actually contain the amino acid Cysteine at the respective positions | |
| extension:subunit |
0..* | Extension | This subclause refers to the description of each subunit constituting the SubstanceProtein. A subunit is a linear sequence of amino acids linked through peptide bonds. The Subunit information shall be provided when the finished SubstanceProtein is a complex of multiple sequences; subunits are not used to delineate domains within a single sequence. Subunits are listed in order of decreasing length; sequences of the same length will be ordered by decreasing molecular weight; subunits that have identical sequences will be repeated multiple times Constraints: ext-1 | |
| id |
0..1 | id | Unique id for inter-element referencing | |
| Slices for extension |
0..* | Extension | Extension Slice: Unordered, Closed by value:url Constraints: ext-1 | |
| extension:subunit |
0..1 | Extension | Index of primary sequences of amino acids linked through peptide bonds in order of decreasing length. Sequences of the same length will be ordered by molecular weight. Subunits that have identical sequences will be repeated and have sequential subscripts Constraints: ext-1 | |
| id |
0..1 | id | Unique id for inter-element referencing | |
| extension |
0..* | Extension | Additional content defined by implementations Slice: Unordered, Open by value:url Constraints: ext-1 | |
| url |
1..1 | uri | "subunit" | |
| value[x] |
0..1 | integer | Index of primary sequences of amino acids linked through peptide bonds in order of decreasing length. Sequences of the same length will be ordered by molecular weight. Subunits that have identical sequences will be repeated and have sequential subscripts | |
| extension:sequence |
0..1 | Extension | The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence Constraints: ext-1 | |
| id |
0..1 | id | Unique id for inter-element referencing | |
| extension |
0..* | Extension | Additional content defined by implementations Slice: Unordered, Open by value:url Constraints: ext-1 | |
| url |
1..1 | uri | "sequence" | |
| value[x] |
0..1 | string | The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence | |
| extension:length |
0..1 | Extension | Length of linear sequences of amino acids contained in the subunit Constraints: ext-1 | |
| id |
0..1 | id | Unique id for inter-element referencing | |
| extension |
0..* | Extension | Additional content defined by implementations Slice: Unordered, Open by value:url Constraints: ext-1 | |
| url |
1..1 | uri | "length" | |
| value[x] |
0..1 | integer | Length of linear sequences of amino acids contained in the subunit | |
| extension:sequenceAttachment |
0..1 | Extension | The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence Constraints: ext-1 | |
| id |
0..1 | id | Unique id for inter-element referencing | |
| extension |
0..* | Extension | Additional content defined by implementations Slice: Unordered, Open by value:url Constraints: ext-1 | |
| url |
1..1 | uri | "sequenceAttachment" | |
| value[x] |
0..1 | Attachment | The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence | |
| extension:nTerminalModificationId |
0..1 | Extension | Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID Constraints: ext-1 | |
| id |
0..1 | id | Unique id for inter-element referencing | |
| extension |
0..* | Extension | Additional content defined by implementations Slice: Unordered, Open by value:url Constraints: ext-1 | |
| url |
1..1 | uri | "nTerminalModificationId" | |
| value[x] |
0..1 | Identifier | Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID | |
| extension:nTerminalModification |
0..1 | Extension | The name of the fragment modified at the N-terminal of the SubstanceProtein shall be specified Constraints: ext-1 | |
| id |
0..1 | id | Unique id for inter-element referencing | |
| extension |
0..* | Extension | Additional content defined by implementations Slice: Unordered, Open by value:url Constraints: ext-1 | |
| url |
1..1 | uri | "nTerminalModification" | |
| value[x] |
0..1 | string | The name of the fragment modified at the N-terminal of the SubstanceProtein shall be specified | |
| extension:cTerminalModificationId |
0..1 | Extension | Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID Constraints: ext-1 | |
| id |
0..1 | id | Unique id for inter-element referencing | |
| extension |
0..* | Extension | Additional content defined by implementations Slice: Unordered, Open by value:url Constraints: ext-1 | |
| url |
1..1 | uri | "cTerminalModificationId" | |
| value[x] |
0..1 | Identifier | Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID | |
| extension:cTerminalModification |
0..1 | Extension | The modification at the C-terminal shall be specified Constraints: ext-1 | |
| id |
0..1 | id | Unique id for inter-element referencing | |
| extension |
0..* | Extension | Additional content defined by implementations Slice: Unordered, Open by value:url Constraints: ext-1 | |
| url |
1..1 | uri | "cTerminalModification" | |
| value[x] |
0..1 | string | The modification at the C-terminal shall be specified | |
| url |
1..1 | uri | "subunit" | |
  value[x] |
0..1 | Value of extension | ||
| valueBase64Binary |
base64Binary | |||
| valueBoolean |
boolean | |||
 valueCanonical |
canonical(Any) | |||
| valueCode |
code | |||
| valueDate |
date | |||
| valueDateTime |
dateTime | |||
| valueDecimal |
decimal | |||
| valueId |
id | |||
| valueInstant |
instant | |||
| valueInteger |
integer | |||
| valueMarkdown |
markdown | |||
| valueOid |
oid | |||
| valuePositiveInt |
positiveInt | |||
| valueString |
string | |||
| valueTime |
time | |||
| valueUnsignedInt |
unsignedInt | |||
| valueUri |
uri | |||
| valueUrl |
url | |||
| valueUuid |
uuid | |||
| valueAddress |
Address | |||
| valueAge |
Age | |||
| valueAnnotation |
Annotation | |||
| valueAttachment |
Attachment | |||
| valueCodeableConcept |
CodeableConcept | |||
| valueCodeableReference |
CodeableReference | |||
| valueCoding |
Coding | |||
| valueContactPoint |
ContactPoint | |||
| valueCount |
Count | |||
| valueDistance |
Distance | |||
| valueDuration |
Duration | |||
| valueHumanName |
HumanName | |||
| valueIdentifier |
Identifier | |||
| valueMoney |
Money | |||
| valuePeriod |
Period | |||
| valueQuantity |
Quantity | |||
| valueRange |
Range | |||
| valueRatio |
Ratio | |||
| valueRatioRange |
RatioRange | |||
| valueReference |
Reference(Any) | |||
| valueSampledData |
SampledData | |||
| valueSignature |
Signature | |||
| valueTiming |
Timing | |||
| valueContactDetail |
ContactDetail | |||
| valueContributor |
Contributor | |||
| valueDataRequirement |
DataRequirement | |||
| valueExpression |
Expression | |||
| valueParameterDefinition |
ParameterDefinition | |||
| valueRelatedArtifact |
RelatedArtifact | |||
| valueTriggerDefinition |
TriggerDefinition | |||
| valueUsageContext |
UsageContext | |||
| valueDosage |
Dosage | |||
| url |
1..1 | uri | "http://hl7.org/fhir/4.0/StructureDefinition/extension-SubstanceProtein" | |
 value[x] |
0..1 | Value of extension | ||
| valueBase64Binary |
base64Binary | |||
| valueBoolean |
boolean | |||
| valueCanonical |
canonical(Any) | |||
| valueCode |
code | |||
| valueDate |
date | |||
| valueDateTime |
dateTime | |||
| valueDecimal |
decimal | |||
| valueId |
id | |||
| valueInstant |
instant | |||
| valueInteger |
integer | |||
| valueMarkdown |
markdown | |||
| valueOid |
oid | |||
| valuePositiveInt |
positiveInt | |||
| valueString |
string | |||
| valueTime |
time | |||
| valueUnsignedInt |
unsignedInt | |||
| valueUri |
uri | |||
| valueUrl |
url | |||
| valueUuid |
uuid | |||
| valueAddress |
Address | |||
| valueAge |
Age | |||
| valueAnnotation |
Annotation | |||
| valueAttachment |
Attachment | |||
| valueCodeableConcept |
CodeableConcept | |||
| valueCodeableReference |
CodeableReference | |||
| valueCoding |
Coding | |||
| valueContactPoint |
ContactPoint | |||
| valueCount |
Count | |||
| valueDistance |
Distance | |||
| valueDuration |
Duration | |||
| valueHumanName |
HumanName | |||
| valueIdentifier |
Identifier | |||
| valueMoney |
Money | |||
| valuePeriod |
Period | |||
| valueQuantity |
Quantity | |||
| valueRange |
Range | |||
| valueRatio |
Ratio | |||
| valueRatioRange |
RatioRange | |||
| valueReference |
Reference(Any) | |||
| valueSampledData |
SampledData | |||
| valueSignature |
Signature | |||
| valueTiming |
Timing | |||
| valueContactDetail |
ContactDetail | |||
| valueContributor |
Contributor | |||
| valueDataRequirement |
DataRequirement | |||
| valueExpression |
Expression | |||
| valueParameterDefinition |
ParameterDefinition | |||
| valueRelatedArtifact |
RelatedArtifact | |||
| valueTriggerDefinition |
TriggerDefinition | |||
| valueUsageContext |
UsageContext | |||
| valueDosage |
Dosage | |||
| Documentation for this format | ||||
This structure is derived from Extension
Summary
Simple Extension with the type base64Binary, boolean, canonical, code, date, dateTime, decimal, id, instant, integer, markdown, oid, positiveInt, string, time, unsignedInt, uri, url, uuid, Address, Age, Annotation, Attachment, CodeableConcept, CodeableReference, Coding, ContactPoint, Count, Distance, Duration, HumanName, Identifier, Money, Period, Quantity, Range, Ratio, RatioRange, Reference, SampledData, Signature, Timing, ContactDetail, Contributor, DataRequirement, Expression, ParameterDefinition, RelatedArtifact, TriggerDefinition, UsageContext, Dosage: This cross-version extension represents SubstanceProtein from http://hl7.org/fhir/StructureDefinition/SubstanceProtein|4.0.1 for use in FHIR R4B.
Maturity: 0
Differential View
This structure is derived from Extension
| Name | Flags | Card. | Type | Description & Constraints Filter: |
|---|---|---|---|---|
| Extension |
0..* | Extension(4.3.0) | A SubstanceProtein is defined as a single unit of a linear amino acid sequence, or a combination of subunits that are either covalently linked or have a defined invariant stoichiometric relationship. This includes all synthetic, recombinant and purified SubstanceProteins of defined sequence, whether the use is therapeutic or prophylactic. This set of elements will be used to describe albumins, coagulation factors, cytokines, growth factors, peptide/SubstanceProtein hormones, enzymes, toxins, toxoids, recombinant vaccines, and immunomodulators | |
| Slices for extension |
0..* | Extension | Extension Slice: Unordered, Closed by value:url | |
| extension:sequenceType |
0..1 | Extension | The SubstanceProtein descriptive elements will only be used when a complete or partial amino acid sequence is available or derivable from a nucleic acid sequence | |
| url |
1..1 | uri | "sequenceType" | |
| value[x] |
0..1 | CodeableConcept | The SubstanceProtein descriptive elements will only be used when a complete or partial amino acid sequence is available or derivable from a nucleic acid sequence | |
| extension:numberOfSubunits |
0..1 | Extension | Number of linear sequences of amino acids linked through peptide bonds. The number of subunits constituting the SubstanceProtein shall be described. It is possible that the number of subunits can be variable | |
| url |
1..1 | uri | "numberOfSubunits" | |
| value[x] |
0..1 | integer | Number of linear sequences of amino acids linked through peptide bonds. The number of subunits constituting the SubstanceProtein shall be described. It is possible that the number of subunits can be variable | |
| extension:disulfideLinkage |
0..* | Extension | The disulphide bond between two cysteine residues either on the same subunit or on two different subunits shall be described. The position of the disulfide bonds in the SubstanceProtein shall be listed in increasing order of subunit number and position within subunit followed by the abbreviation of the amino acids involved. The disulfide linkage positions shall actually contain the amino acid Cysteine at the respective positions | |
| url |
1..1 | uri | "disulfideLinkage" | |
| value[x] |
0..1 | string | The disulphide bond between two cysteine residues either on the same subunit or on two different subunits shall be described. The position of the disulfide bonds in the SubstanceProtein shall be listed in increasing order of subunit number and position within subunit followed by the abbreviation of the amino acids involved. The disulfide linkage positions shall actually contain the amino acid Cysteine at the respective positions | |
| extension:subunit |
0..* | Extension | This subclause refers to the description of each subunit constituting the SubstanceProtein. A subunit is a linear sequence of amino acids linked through peptide bonds. The Subunit information shall be provided when the finished SubstanceProtein is a complex of multiple sequences; subunits are not used to delineate domains within a single sequence. Subunits are listed in order of decreasing length; sequences of the same length will be ordered by decreasing molecular weight; subunits that have identical sequences will be repeated multiple times | |
| Slices for extension |
0..* | Extension | Extension Slice: Unordered, Closed by value:url | |
| extension:subunit |
0..1 | Extension | Index of primary sequences of amino acids linked through peptide bonds in order of decreasing length. Sequences of the same length will be ordered by molecular weight. Subunits that have identical sequences will be repeated and have sequential subscripts | |
| url |
1..1 | uri | "subunit" | |
| value[x] |
0..1 | integer | Index of primary sequences of amino acids linked through peptide bonds in order of decreasing length. Sequences of the same length will be ordered by molecular weight. Subunits that have identical sequences will be repeated and have sequential subscripts | |
| extension:sequence |
0..1 | Extension | The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence | |
| url |
1..1 | uri | "sequence" | |
| value[x] |
0..1 | string | The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence | |
| extension:length |
0..1 | Extension | Length of linear sequences of amino acids contained in the subunit | |
| url |
1..1 | uri | "length" | |
| value[x] |
0..1 | integer | Length of linear sequences of amino acids contained in the subunit | |
| extension:sequenceAttachment |
0..1 | Extension | The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence | |
| url |
1..1 | uri | "sequenceAttachment" | |
| value[x] |
0..1 | Attachment | The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence | |
| extension:nTerminalModificationId |
0..1 | Extension | Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID | |
| url |
1..1 | uri | "nTerminalModificationId" | |
| value[x] |
0..1 | Identifier | Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID | |
| extension:nTerminalModification |
0..1 | Extension | The name of the fragment modified at the N-terminal of the SubstanceProtein shall be specified | |
| url |
1..1 | uri | "nTerminalModification" | |
| value[x] |
0..1 | string | The name of the fragment modified at the N-terminal of the SubstanceProtein shall be specified | |
| extension:cTerminalModificationId |
0..1 | Extension | Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID | |
| url |
1..1 | uri | "cTerminalModificationId" | |
| value[x] |
0..1 | Identifier | Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID | |
| extension:cTerminalModification |
0..1 | Extension | The modification at the C-terminal shall be specified | |
| url |
1..1 | uri | "cTerminalModification" | |
| value[x] |
0..1 | string | The modification at the C-terminal shall be specified | |
| url |
1..1 | uri | "subunit" | |
| url |
1..1 | uri | "http://hl7.org/fhir/4.0/StructureDefinition/extension-SubstanceProtein" | |
| Documentation for this format | ||||
Snapshot View
| Name | Flags | Card. | Type | Description & Constraints Filter: |
|---|---|---|---|---|
| Extension |
0..* | Extension(4.3.0) | A SubstanceProtein is defined as a single unit of a linear amino acid sequence, or a combination of subunits that are either covalently linked or have a defined invariant stoichiometric relationship. This includes all synthetic, recombinant and purified SubstanceProteins of defined sequence, whether the use is therapeutic or prophylactic. This set of elements will be used to describe albumins, coagulation factors, cytokines, growth factors, peptide/SubstanceProtein hormones, enzymes, toxins, toxoids, recombinant vaccines, and immunomodulators Constraints: ext-1 | |
| id |
0..1 | id | Unique id for inter-element referencing | |
| Slices for extension |
0..* | Extension | Extension Slice: Unordered, Closed by value:url Constraints: ext-1 | |
| extension:sequenceType |
0..1 | Extension | The SubstanceProtein descriptive elements will only be used when a complete or partial amino acid sequence is available or derivable from a nucleic acid sequence Constraints: ext-1 | |
| id |
0..1 | id | Unique id for inter-element referencing | |
| extension |
0..* | Extension | Additional content defined by implementations Slice: Unordered, Open by value:url Constraints: ext-1 | |
| url |
1..1 | uri | "sequenceType" | |
| value[x] |
0..1 | CodeableConcept | The SubstanceProtein descriptive elements will only be used when a complete or partial amino acid sequence is available or derivable from a nucleic acid sequence | |
| extension:numberOfSubunits |
0..1 | Extension | Number of linear sequences of amino acids linked through peptide bonds. The number of subunits constituting the SubstanceProtein shall be described. It is possible that the number of subunits can be variable Constraints: ext-1 | |
| id |
0..1 | id | Unique id for inter-element referencing | |
| extension |
0..* | Extension | Additional content defined by implementations Slice: Unordered, Open by value:url Constraints: ext-1 | |
| url |
1..1 | uri | "numberOfSubunits" | |
| value[x] |
0..1 | integer | Number of linear sequences of amino acids linked through peptide bonds. The number of subunits constituting the SubstanceProtein shall be described. It is possible that the number of subunits can be variable | |
| extension:disulfideLinkage |
0..* | Extension | The disulphide bond between two cysteine residues either on the same subunit or on two different subunits shall be described. The position of the disulfide bonds in the SubstanceProtein shall be listed in increasing order of subunit number and position within subunit followed by the abbreviation of the amino acids involved. The disulfide linkage positions shall actually contain the amino acid Cysteine at the respective positions Constraints: ext-1 | |
| id |
0..1 | id | Unique id for inter-element referencing | |
| extension |
0..* | Extension | Additional content defined by implementations Slice: Unordered, Open by value:url Constraints: ext-1 | |
| url |
1..1 | uri | "disulfideLinkage" | |
| value[x] |
0..1 | string | The disulphide bond between two cysteine residues either on the same subunit or on two different subunits shall be described. The position of the disulfide bonds in the SubstanceProtein shall be listed in increasing order of subunit number and position within subunit followed by the abbreviation of the amino acids involved. The disulfide linkage positions shall actually contain the amino acid Cysteine at the respective positions | |
| extension:subunit |
0..* | Extension | This subclause refers to the description of each subunit constituting the SubstanceProtein. A subunit is a linear sequence of amino acids linked through peptide bonds. The Subunit information shall be provided when the finished SubstanceProtein is a complex of multiple sequences; subunits are not used to delineate domains within a single sequence. Subunits are listed in order of decreasing length; sequences of the same length will be ordered by decreasing molecular weight; subunits that have identical sequences will be repeated multiple times Constraints: ext-1 | |
| id |
0..1 | id | Unique id for inter-element referencing | |
| Slices for extension |
0..* | Extension | Extension Slice: Unordered, Closed by value:url Constraints: ext-1 | |
| extension:subunit |
0..1 | Extension | Index of primary sequences of amino acids linked through peptide bonds in order of decreasing length. Sequences of the same length will be ordered by molecular weight. Subunits that have identical sequences will be repeated and have sequential subscripts Constraints: ext-1 | |
| id |
0..1 | id | Unique id for inter-element referencing | |
| extension |
0..* | Extension | Additional content defined by implementations Slice: Unordered, Open by value:url Constraints: ext-1 | |
| url |
1..1 | uri | "subunit" | |
| value[x] |
0..1 | integer | Index of primary sequences of amino acids linked through peptide bonds in order of decreasing length. Sequences of the same length will be ordered by molecular weight. Subunits that have identical sequences will be repeated and have sequential subscripts | |
| extension:sequence |
0..1 | Extension | The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence Constraints: ext-1 | |
| id |
0..1 | id | Unique id for inter-element referencing | |
| extension |
0..* | Extension | Additional content defined by implementations Slice: Unordered, Open by value:url Constraints: ext-1 | |
| url |
1..1 | uri | "sequence" | |
| value[x] |
0..1 | string | The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence | |
| extension:length |
0..1 | Extension | Length of linear sequences of amino acids contained in the subunit Constraints: ext-1 | |
| id |
0..1 | id | Unique id for inter-element referencing | |
| extension |
0..* | Extension | Additional content defined by implementations Slice: Unordered, Open by value:url Constraints: ext-1 | |
| url |
1..1 | uri | "length" | |
| value[x] |
0..1 | integer | Length of linear sequences of amino acids contained in the subunit | |
| extension:sequenceAttachment |
0..1 | Extension | The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence Constraints: ext-1 | |
| id |
0..1 | id | Unique id for inter-element referencing | |
| extension |
0..* | Extension | Additional content defined by implementations Slice: Unordered, Open by value:url Constraints: ext-1 | |
| url |
1..1 | uri | "sequenceAttachment" | |
| value[x] |
0..1 | Attachment | The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence | |
| extension:nTerminalModificationId |
0..1 | Extension | Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID Constraints: ext-1 | |
| id |
0..1 | id | Unique id for inter-element referencing | |
| extension |
0..* | Extension | Additional content defined by implementations Slice: Unordered, Open by value:url Constraints: ext-1 | |
| url |
1..1 | uri | "nTerminalModificationId" | |
| value[x] |
0..1 | Identifier | Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID | |
| extension:nTerminalModification |
0..1 | Extension | The name of the fragment modified at the N-terminal of the SubstanceProtein shall be specified Constraints: ext-1 | |
| id |
0..1 | id | Unique id for inter-element referencing | |
| extension |
0..* | Extension | Additional content defined by implementations Slice: Unordered, Open by value:url Constraints: ext-1 | |
| url |
1..1 | uri | "nTerminalModification" | |
| value[x] |
0..1 | string | The name of the fragment modified at the N-terminal of the SubstanceProtein shall be specified | |
| extension:cTerminalModificationId |
0..1 | Extension | Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID Constraints: ext-1 | |
| id |
0..1 | id | Unique id for inter-element referencing | |
| extension |
0..* | Extension | Additional content defined by implementations Slice: Unordered, Open by value:url Constraints: ext-1 | |
| url |
1..1 | uri | "cTerminalModificationId" | |
| value[x] |
0..1 | Identifier | Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID | |
| extension:cTerminalModification |
0..1 | Extension | The modification at the C-terminal shall be specified Constraints: ext-1 | |
| id |
0..1 | id | Unique id for inter-element referencing | |
| extension |
0..* | Extension | Additional content defined by implementations Slice: Unordered, Open by value:url Constraints: ext-1 | |
| url |
1..1 | uri | "cTerminalModification" | |
| value[x] |
0..1 | string | The modification at the C-terminal shall be specified | |
| url |
1..1 | uri | "subunit" | |
| value[x] |
0..1 | Value of extension | ||
| valueBase64Binary |
base64Binary | |||
| valueBoolean |
boolean | |||
| valueCanonical |
canonical(Any) | |||
| valueCode |
code | |||
| valueDate |
date | |||
| valueDateTime |
dateTime | |||
| valueDecimal |
decimal | |||
| valueId |
id | |||
| valueInstant |
instant | |||
| valueInteger |
integer | |||
| valueMarkdown |
markdown | |||
| valueOid |
oid | |||
| valuePositiveInt |
positiveInt | |||
| valueString |
string | |||
| valueTime |
time | |||
| valueUnsignedInt |
unsignedInt | |||
| valueUri |
uri | |||
| valueUrl |
url | |||
| valueUuid |
uuid | |||
| valueAddress |
Address | |||
| valueAge |
Age | |||
| valueAnnotation |
Annotation | |||
| valueAttachment |
Attachment | |||
| valueCodeableConcept |
CodeableConcept | |||
| valueCodeableReference |
CodeableReference | |||
| valueCoding |
Coding | |||
| valueContactPoint |
ContactPoint | |||
| valueCount |
Count | |||
| valueDistance |
Distance | |||
| valueDuration |
Duration | |||
| valueHumanName |
HumanName | |||
| valueIdentifier |
Identifier | |||
| valueMoney |
Money | |||
| valuePeriod |
Period | |||
| valueQuantity |
Quantity | |||
| valueRange |
Range | |||
| valueRatio |
Ratio | |||
| valueRatioRange |
RatioRange | |||
| valueReference |
Reference(Any) | |||
| valueSampledData |
SampledData | |||
| valueSignature |
Signature | |||
| valueTiming |
Timing | |||
| valueContactDetail |
ContactDetail | |||
| valueContributor |
Contributor | |||
| valueDataRequirement |
DataRequirement | |||
| valueExpression |
Expression | |||
| valueParameterDefinition |
ParameterDefinition | |||
| valueRelatedArtifact |
RelatedArtifact | |||
| valueTriggerDefinition |
TriggerDefinition | |||
| valueUsageContext |
UsageContext | |||
| valueDosage |
Dosage | |||
| url |
1..1 | uri | "http://hl7.org/fhir/4.0/StructureDefinition/extension-SubstanceProtein" | |
| value[x] |
0..1 | Value of extension | ||
| valueBase64Binary |
base64Binary | |||
| valueBoolean |
boolean | |||
| valueCanonical |
canonical(Any) | |||
| valueCode |
code | |||
| valueDate |
date | |||
| valueDateTime |
dateTime | |||
| valueDecimal |
decimal | |||
| valueId |
id | |||
| valueInstant |
instant | |||
| valueInteger |
integer | |||
| valueMarkdown |
markdown | |||
| valueOid |
oid | |||
| valuePositiveInt |
positiveInt | |||
| valueString |
string | |||
| valueTime |
time | |||
| valueUnsignedInt |
unsignedInt | |||
| valueUri |
uri | |||
| valueUrl |
url | |||
| valueUuid |
uuid | |||
| valueAddress |
Address | |||
| valueAge |
Age | |||
| valueAnnotation |
Annotation | |||
| valueAttachment |
Attachment | |||
| valueCodeableConcept |
CodeableConcept | |||
| valueCodeableReference |
CodeableReference | |||
| valueCoding |
Coding | |||
| valueContactPoint |
ContactPoint | |||
| valueCount |
Count | |||
| valueDistance |
Distance | |||
| valueDuration |
Duration | |||
| valueHumanName |
HumanName | |||
| valueIdentifier |
Identifier | |||
| valueMoney |
Money | |||
| valuePeriod |
Period | |||
| valueQuantity |
Quantity | |||
| valueRange |
Range | |||
| valueRatio |
Ratio | |||
| valueRatioRange |
RatioRange | |||
| valueReference |
Reference(Any) | |||
| valueSampledData |
SampledData | |||
| valueSignature |
Signature | |||
| valueTiming |
Timing | |||
| valueContactDetail |
ContactDetail | |||
| valueContributor |
Contributor | |||
| valueDataRequirement |
DataRequirement | |||
| valueExpression |
Expression | |||
| valueParameterDefinition |
ParameterDefinition | |||
| valueRelatedArtifact |
RelatedArtifact | |||
| valueTriggerDefinition |
TriggerDefinition | |||
| valueUsageContext |
UsageContext | |||
| valueDosage |
Dosage | |||
| Documentation for this format | ||||
Other representations of profile: CSV, Excel, Schematron
| Id | Grade | Path(s) | Details | Requirements |
| ele-1 | error | Extension, Extension.extension, Extension.extension:sequenceType, Extension.extension:sequenceType.extension, Extension.extension:sequenceType.value[x], Extension.extension:numberOfSubunits, Extension.extension:numberOfSubunits.extension, Extension.extension:numberOfSubunits.value[x], Extension.extension:disulfideLinkage, Extension.extension:disulfideLinkage.extension, Extension.extension:disulfideLinkage.value[x], Extension.extension:subunit, Extension.extension:subunit.extension, Extension.extension:subunit.extension:subunit, Extension.extension:subunit.extension:subunit.extension, Extension.extension:subunit.extension:subunit.value[x], Extension.extension:subunit.extension:sequence, Extension.extension:subunit.extension:sequence.extension, Extension.extension:subunit.extension:sequence.value[x], Extension.extension:subunit.extension:length, Extension.extension:subunit.extension:length.extension, Extension.extension:subunit.extension:length.value[x], Extension.extension:subunit.extension:sequenceAttachment, Extension.extension:subunit.extension:sequenceAttachment.extension, Extension.extension:subunit.extension:sequenceAttachment.value[x], Extension.extension:subunit.extension:nTerminalModificationId, Extension.extension:subunit.extension:nTerminalModificationId.extension, Extension.extension:subunit.extension:nTerminalModificationId.value[x], Extension.extension:subunit.extension:nTerminalModification, Extension.extension:subunit.extension:nTerminalModification.extension, Extension.extension:subunit.extension:nTerminalModification.value[x], Extension.extension:subunit.extension:cTerminalModificationId, Extension.extension:subunit.extension:cTerminalModificationId.extension, Extension.extension:subunit.extension:cTerminalModificationId.value[x], Extension.extension:subunit.extension:cTerminalModification, Extension.extension:subunit.extension:cTerminalModification.extension, Extension.extension:subunit.extension:cTerminalModification.value[x], Extension.extension:subunit.value[x], Extension.value[x] | All FHIR elements must have a @value or children unless an empty Parameters resource : hasValue() or (children().count() > id.count()) or $this is Parameters | |
| ext-1 | error | Extension, Extension.extension, Extension.extension:sequenceType, Extension.extension:sequenceType.extension, Extension.extension:numberOfSubunits, Extension.extension:numberOfSubunits.extension, Extension.extension:disulfideLinkage, Extension.extension:disulfideLinkage.extension, Extension.extension:subunit, Extension.extension:subunit.extension, Extension.extension:subunit.extension:subunit, Extension.extension:subunit.extension:subunit.extension, Extension.extension:subunit.extension:sequence, Extension.extension:subunit.extension:sequence.extension, Extension.extension:subunit.extension:length, Extension.extension:subunit.extension:length.extension, Extension.extension:subunit.extension:sequenceAttachment, Extension.extension:subunit.extension:sequenceAttachment.extension, Extension.extension:subunit.extension:nTerminalModificationId, Extension.extension:subunit.extension:nTerminalModificationId.extension, Extension.extension:subunit.extension:nTerminalModification, Extension.extension:subunit.extension:nTerminalModification.extension, Extension.extension:subunit.extension:cTerminalModificationId, Extension.extension:subunit.extension:cTerminalModificationId.extension, Extension.extension:subunit.extension:cTerminalModification, Extension.extension:subunit.extension:cTerminalModification.extension | Must have either extensions or value[x], not both : extension.exists() != value.exists() |
IG © 2025+ FHIR Infrastructure. Package hl7.fhir.uv.xver-r4.r4b#0.0.1-snapshot-2 based on FHIR 4.3.0. Generated 2025-09-13
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