Cross-version Extension for R4.EffectEvidenceSynthesis for use in FHIR R4B - Definitions - FHIR Cross-Version Extensions package for FHIR R4B from FHIR R4 v0.0.1-snapshot-2

FHIR Cross-Version Extensions package for FHIR R4B from FHIR R4 - Version 0.0.1-snapshot-2. See the Directory of published versions

Extension: Ext_R4_EffectEvidenceSynthesis - Detailed Descriptions

Page standards status: Informative

Maturity Level: 0

Definitions for the ext-R4-EffectEvidenceSynthesis extension.

Differential Elements Table
Key Elements Table
Snapshot Elements Table

Guidance on how to interpret the contents of this table can be foundhere

0. Extension
Definition	The EffectEvidenceSynthesis resource describes the difference in an outcome between exposures states in a population where the effect estimate is derived from a combination of research studies.
Short	A quantified estimate of effect based on a body of evidence
Control	0..*
2. Extension.extension
Control	5..*
Slicing	This element introduces a set of slices on `Extension.extension`. The slices areUnordered and Closed, and can be differentiated using the following discriminators: value @ url
4. Extension.extension:url
Slice Name	url
Definition	An absolute URI that is used to identify this effect evidence synthesis when it is referenced in a specification, model, design or an instance; also called its canonical identifier. This SHOULD be globally unique and SHOULD be a literal address at which at which an authoritative instance of this effect evidence synthesis is (or will be) published. This URL can be the target of a canonical reference. It SHALL remain the same when the effect evidence synthesis is stored on different servers.
Short	Canonical identifier for this effect evidence synthesis, represented as a URI (globally unique)
Control	0..1
6. Extension.extension:url.url
Control	1..1
Fixed Value	`url`
8. Extension.extension:url.value[x]
Definition	An absolute URI that is used to identify this effect evidence synthesis when it is referenced in a specification, model, design or an instance; also called its canonical identifier. This SHOULD be globally unique and SHOULD be a literal address at which at which an authoritative instance of this effect evidence synthesis is (or will be) published. This URL can be the target of a canonical reference. It SHALL remain the same when the effect evidence synthesis is stored on different servers.
Short	Canonical identifier for this effect evidence synthesis, represented as a URI (globally unique)
Type	uri
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
10. Extension.extension:version
Slice Name	version
Definition	The identifier that is used to identify this version of the effect evidence synthesis when it is referenced in a specification, model, design or instance. This is an arbitrary value managed by the effect evidence synthesis author and is not expected to be globally unique. For example, it might be a timestamp (e.g. yyyymmdd) if a managed version is not available. There is also no expectation that versions can be placed in a lexicographical sequence.
Short	Business version of the effect evidence synthesis
Control	0..1
12. Extension.extension:version.url
Control	1..1
Fixed Value	`version`
14. Extension.extension:version.value[x]
Definition	The identifier that is used to identify this version of the effect evidence synthesis when it is referenced in a specification, model, design or instance. This is an arbitrary value managed by the effect evidence synthesis author and is not expected to be globally unique. For example, it might be a timestamp (e.g. yyyymmdd) if a managed version is not available. There is also no expectation that versions can be placed in a lexicographical sequence.
Short	Business version of the effect evidence synthesis
Type	string
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
16. Extension.extension:name
Slice Name	name
Definition	A natural language name identifying the effect evidence synthesis. This name should be usable as an identifier for the module by machine processing applications such as code generation.
Short	Name for this effect evidence synthesis (computer friendly)
Control	0..1
18. Extension.extension:name.url
Control	1..1
Fixed Value	`name`
20. Extension.extension:name.value[x]
Definition	A natural language name identifying the effect evidence synthesis. This name should be usable as an identifier for the module by machine processing applications such as code generation.
Short	Name for this effect evidence synthesis (computer friendly)
Type	string
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
22. Extension.extension:title
Slice Name	title
Definition	A short, descriptive, user-friendly title for the effect evidence synthesis.
Short	Name for this effect evidence synthesis (human friendly)
Control	0..1
24. Extension.extension:title.url
Control	1..1
Fixed Value	`title`
26. Extension.extension:title.value[x]
Definition	A short, descriptive, user-friendly title for the effect evidence synthesis.
Short	Name for this effect evidence synthesis (human friendly)
Type	string
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
28. Extension.extension:status
Slice Name	status
Definition	The status of this effect evidence synthesis. Enables tracking the life-cycle of the content.
Short	draft \| active \| retired \| unknown
Control	1..1
30. Extension.extension:status.url
Control	1..1
Fixed Value	`status`
32. Extension.extension:status.value[x]
Definition	The status of this effect evidence synthesis. Enables tracking the life-cycle of the content.
Short	draft \| active \| retired \| unknown
Binding	The codes SHALL be taken from R4_publication_status_for_R4B (0.0.1-snapshot-2) (required to `http://hl7.org/fhir/4.0/ValueSet/R4-publication-status-for-R4B\|0.0.1-snapshot-2`) The lifecycle status of an artifact.
Type	code
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
34. Extension.extension:date
Slice Name	date
Definition	The date (and optionally time) when the effect evidence synthesis was published. The date must change when the business version changes and it must change if the status code changes. In addition, it should change when the substantive content of the effect evidence synthesis changes.
Short	Date last changed
Control	0..1
36. Extension.extension:date.url
Control	1..1
Fixed Value	`date`
38. Extension.extension:date.value[x]
Definition	The date (and optionally time) when the effect evidence synthesis was published. The date must change when the business version changes and it must change if the status code changes. In addition, it should change when the substantive content of the effect evidence synthesis changes.
Short	Date last changed
Type	dateTime
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
40. Extension.extension:publisher
Slice Name	publisher
Definition	The name of the organization or individual that published the effect evidence synthesis.
Short	Name of the publisher (organization or individual)
Control	0..1
42. Extension.extension:publisher.url
Control	1..1
Fixed Value	`publisher`
44. Extension.extension:publisher.value[x]
Definition	The name of the organization or individual that published the effect evidence synthesis.
Short	Name of the publisher (organization or individual)
Type	string
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
46. Extension.extension:contact
Slice Name	contact
Definition	Contact details to assist a user in finding and communicating with the publisher.
Short	Contact details for the publisher
Control	0..*
48. Extension.extension:contact.url
Control	1..1
Fixed Value	`contact`
50. Extension.extension:contact.value[x]
Definition	Contact details to assist a user in finding and communicating with the publisher.
Short	Contact details for the publisher
Type	ContactDetail
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
52. Extension.extension:description
Slice Name	description
Definition	A free text natural language description of the effect evidence synthesis from a consumer's perspective.
Short	Natural language description of the effect evidence synthesis
Control	0..1
54. Extension.extension:description.url
Control	1..1
Fixed Value	`description`
56. Extension.extension:description.value[x]
Definition	A free text natural language description of the effect evidence synthesis from a consumer's perspective.
Short	Natural language description of the effect evidence synthesis
Type	markdown
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
58. Extension.extension:note
Slice Name	note
Definition	A human-readable string to clarify or explain concepts about the resource.
Short	Used for footnotes or explanatory notes
Control	0..*
60. Extension.extension:note.url
Control	1..1
Fixed Value	`note`
62. Extension.extension:note.value[x]
Definition	A human-readable string to clarify or explain concepts about the resource.
Short	Used for footnotes or explanatory notes
Type	Annotation
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
64. Extension.extension:useContext
Slice Name	useContext
Definition	The content was developed with a focus and intent of supporting the contexts that are listed. These contexts may be general categories (gender, age, ...) or may be references to specific programs (insurance plans, studies, ...) and may be used to assist with indexing and searching for appropriate effect evidence synthesis instances.
Short	The context that the content is intended to support
Control	0..*
66. Extension.extension:useContext.url
Control	1..1
Fixed Value	`useContext`
68. Extension.extension:useContext.value[x]
Definition	The content was developed with a focus and intent of supporting the contexts that are listed. These contexts may be general categories (gender, age, ...) or may be references to specific programs (insurance plans, studies, ...) and may be used to assist with indexing and searching for appropriate effect evidence synthesis instances.
Short	The context that the content is intended to support
Type	UsageContext
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
70. Extension.extension:jurisdiction
Slice Name	jurisdiction
Definition	A legal or geographic region in which the effect evidence synthesis is intended to be used.
Short	Intended jurisdiction for effect evidence synthesis (if applicable)
Control	0..*
72. Extension.extension:jurisdiction.url
Control	1..1
Fixed Value	`jurisdiction`
74. Extension.extension:jurisdiction.value[x]
Definition	A legal or geographic region in which the effect evidence synthesis is intended to be used.
Short	Intended jurisdiction for effect evidence synthesis (if applicable)
Binding	Unless not suitable, these codes SHALL be taken from R4_jurisdiction_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-jurisdiction-for-R4B\|0.0.1-snapshot-2`) Countries and regions within which this artifact is targeted for use.
Type	CodeableConcept
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
76. Extension.extension:copyright
Slice Name	copyright
Definition	A copyright statement relating to the effect evidence synthesis and/or its contents. Copyright statements are generally legal restrictions on the use and publishing of the effect evidence synthesis.
Short	Use and/or publishing restrictions
Control	0..1
78. Extension.extension:copyright.url
Control	1..1
Fixed Value	`copyright`
80. Extension.extension:copyright.value[x]
Definition	A copyright statement relating to the effect evidence synthesis and/or its contents. Copyright statements are generally legal restrictions on the use and publishing of the effect evidence synthesis.
Short	Use and/or publishing restrictions
Type	markdown
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
82. Extension.extension:approvalDate
Slice Name	approvalDate
Definition	The date on which the resource content was approved by the publisher. Approval happens once when the content is officially approved for usage.
Short	When the effect evidence synthesis was approved by publisher
Control	0..1
84. Extension.extension:approvalDate.url
Control	1..1
Fixed Value	`approvalDate`
86. Extension.extension:approvalDate.value[x]
Definition	The date on which the resource content was approved by the publisher. Approval happens once when the content is officially approved for usage.
Short	When the effect evidence synthesis was approved by publisher
Type	date
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
88. Extension.extension:lastReviewDate
Slice Name	lastReviewDate
Definition	The date on which the resource content was last reviewed. Review happens periodically after approval but does not change the original approval date.
Short	When the effect evidence synthesis was last reviewed
Control	0..1
90. Extension.extension:lastReviewDate.url
Control	1..1
Fixed Value	`lastReviewDate`
92. Extension.extension:lastReviewDate.value[x]
Definition	The date on which the resource content was last reviewed. Review happens periodically after approval but does not change the original approval date.
Short	When the effect evidence synthesis was last reviewed
Type	date
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
94. Extension.extension:effectivePeriod
Slice Name	effectivePeriod
Definition	The period during which the effect evidence synthesis content was or is planned to be in active use.
Short	When the effect evidence synthesis is expected to be used
Control	0..1
96. Extension.extension:effectivePeriod.url
Control	1..1
Fixed Value	`effectivePeriod`
98. Extension.extension:effectivePeriod.value[x]
Definition	The period during which the effect evidence synthesis content was or is planned to be in active use.
Short	When the effect evidence synthesis is expected to be used
Type	Period
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
100. Extension.extension:topic
Slice Name	topic
Definition	Descriptive topics related to the content of the EffectEvidenceSynthesis. Topics provide a high-level categorization grouping types of EffectEvidenceSynthesiss that can be useful for filtering and searching.
Short	The category of the EffectEvidenceSynthesis, such as Education, Treatment, Assessment, etc.
Control	0..*
102. Extension.extension:topic.url
Control	1..1
Fixed Value	`topic`
104. Extension.extension:topic.value[x]
Definition	Descriptive topics related to the content of the EffectEvidenceSynthesis. Topics provide a high-level categorization grouping types of EffectEvidenceSynthesiss that can be useful for filtering and searching.
Short	The category of the EffectEvidenceSynthesis, such as Education, Treatment, Assessment, etc.
Binding	For example codes, see R4_definition_topic_for_R4B (0.0.1-snapshot-2) (example to `http://hl7.org/fhir/4.0/ValueSet/R4-definition-topic-for-R4B\|0.0.1-snapshot-2`) High-level categorization of the definition, used for searching, sorting, and filtering.
Type	CodeableConcept
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
106. Extension.extension:editor
Slice Name	editor
Definition	An individual or organization primarily responsible for internal coherence of the content.
Short	Who edited the content
Control	0..*
108. Extension.extension:editor.url
Control	1..1
Fixed Value	`editor`
110. Extension.extension:editor.value[x]
Definition	An individual or organization primarily responsible for internal coherence of the content.
Short	Who edited the content
Type	ContactDetail
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
112. Extension.extension:reviewer
Slice Name	reviewer
Definition	An individual or organization primarily responsible for review of some aspect of the content.
Short	Who reviewed the content
Control	0..*
114. Extension.extension:reviewer.url
Control	1..1
Fixed Value	`reviewer`
116. Extension.extension:reviewer.value[x]
Definition	An individual or organization primarily responsible for review of some aspect of the content.
Short	Who reviewed the content
Type	ContactDetail
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
118. Extension.extension:endorser
Slice Name	endorser
Definition	An individual or organization responsible for officially endorsing the content for use in some setting.
Short	Who endorsed the content
Control	0..*
120. Extension.extension:endorser.url
Control	1..1
Fixed Value	`endorser`
122. Extension.extension:endorser.value[x]
Definition	An individual or organization responsible for officially endorsing the content for use in some setting.
Short	Who endorsed the content
Type	ContactDetail
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
124. Extension.extension:relatedArtifact
Slice Name	relatedArtifact
Definition	Related artifacts such as additional documentation, justification, or bibliographic references.
Short	Additional documentation, citations, etc.
Control	0..*
126. Extension.extension:relatedArtifact.url
Control	1..1
Fixed Value	`relatedArtifact`
128. Extension.extension:relatedArtifact.value[x]
Definition	Related artifacts such as additional documentation, justification, or bibliographic references.
Short	Additional documentation, citations, etc.
Type	RelatedArtifact
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
130. Extension.extension:synthesisType
Slice Name	synthesisType
Definition	Type of synthesis eg meta-analysis.
Short	Type of synthesis
Control	0..1
132. Extension.extension:synthesisType.url
Control	1..1
Fixed Value	`synthesisType`
134. Extension.extension:synthesisType.value[x]
Definition	Type of synthesis eg meta-analysis.
Short	Type of synthesis
Binding	Unless not suitable, these codes SHALL be taken from SynthesisType (extensible to `http://hl7.org/fhir/ValueSet/synthesis-type\|4.3.0`) Types of combining results from a body of evidence (eg. summary data meta-analysis).
Type	CodeableConcept
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
136. Extension.extension:studyType
Slice Name	studyType
Definition	Type of study eg randomized trial.
Short	Type of study
Control	0..1
138. Extension.extension:studyType.url
Control	1..1
Fixed Value	`studyType`
140. Extension.extension:studyType.value[x]
Definition	Type of study eg randomized trial.
Short	Type of study
Binding	Unless not suitable, these codes SHALL be taken from R4_study_type_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-study-type-for-R4B\|0.0.1-snapshot-2`) Types of research studies (types of research methods).
Type	CodeableConcept
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
142. Extension.extension:population
Slice Name	population
Definition	A reference to a EvidenceVariable resource that defines the population for the research.
Short	What population?
Control	1..1
144. Extension.extension:population.url
Control	1..1
Fixed Value	`population`
146. Extension.extension:population.value[x]
Definition	A reference to a EvidenceVariable resource that defines the population for the research.
Short	What population?
Type	Reference
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
148. Extension.extension:exposure
Slice Name	exposure
Definition	A reference to a EvidenceVariable resource that defines the exposure for the research.
Short	What exposure?
Control	1..1
150. Extension.extension:exposure.url
Control	1..1
Fixed Value	`exposure`
152. Extension.extension:exposure.value[x]
Definition	A reference to a EvidenceVariable resource that defines the exposure for the research.
Short	What exposure?
Type	Reference
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
154. Extension.extension:exposureAlternative
Slice Name	exposureAlternative
Definition	A reference to a EvidenceVariable resource that defines the comparison exposure for the research.
Short	What comparison exposure?
Control	1..1
156. Extension.extension:exposureAlternative.url
Control	1..1
Fixed Value	`exposureAlternative`
158. Extension.extension:exposureAlternative.value[x]
Definition	A reference to a EvidenceVariable resource that defines the comparison exposure for the research.
Short	What comparison exposure?
Type	Reference
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
160. Extension.extension:outcome
Slice Name	outcome
Definition	A reference to a EvidenceVariable resomece that defines the outcome for the research.
Short	What outcome?
Control	1..1
162. Extension.extension:outcome.url
Control	1..1
Fixed Value	`outcome`
164. Extension.extension:outcome.value[x]
Definition	A reference to a EvidenceVariable resomece that defines the outcome for the research.
Short	What outcome?
Type	Reference
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
166. Extension.extension:sampleSize
Slice Name	sampleSize
Definition	A description of the size of the sample involved in the synthesis.
Short	What sample size was involved?
Control	0..1
168. Extension.extension:sampleSize.extension
Control	0..*
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Closed, and can be differentiated using the following discriminators: value @ url
170. Extension.extension:sampleSize.extension:description
Slice Name	description
Definition	Human-readable summary of sample size.
Short	Description of sample size
Control	0..1
172. Extension.extension:sampleSize.extension:description.url
Control	1..1
Fixed Value	`description`
174. Extension.extension:sampleSize.extension:description.value[x]
Definition	Human-readable summary of sample size.
Short	Description of sample size
Type	string
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
176. Extension.extension:sampleSize.extension:numberOfStudies
Slice Name	numberOfStudies
Definition	Number of studies included in this evidence synthesis.
Short	How many studies?
Control	0..1
178. Extension.extension:sampleSize.extension:numberOfStudies.url
Control	1..1
Fixed Value	`numberOfStudies`
180. Extension.extension:sampleSize.extension:numberOfStudies.value[x]
Definition	Number of studies included in this evidence synthesis.
Short	How many studies?
Type	integer
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
182. Extension.extension:sampleSize.extension:numberOfParticipants
Slice Name	numberOfParticipants
Definition	Number of participants included in this evidence synthesis.
Short	How many participants?
Control	0..1
184. Extension.extension:sampleSize.extension:numberOfParticipants.url
Control	1..1
Fixed Value	`numberOfParticipants`
186. Extension.extension:sampleSize.extension:numberOfParticipants.value[x]
Definition	Number of participants included in this evidence synthesis.
Short	How many participants?
Type	integer
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
188. Extension.extension:sampleSize.url
Control	1..1
Fixed Value	`sampleSize`
190. Extension.extension:resultsByExposure
Slice Name	resultsByExposure
Definition	A description of the results for each exposure considered in the effect estimate.
Short	What was the result per exposure?
Control	0..*
192. Extension.extension:resultsByExposure.extension
Control	1..*
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Closed, and can be differentiated using the following discriminators: value @ url
194. Extension.extension:resultsByExposure.extension:description
Slice Name	description
Definition	Human-readable summary of results by exposure state.
Short	Description of results by exposure
Control	0..1
196. Extension.extension:resultsByExposure.extension:description.url
Control	1..1
Fixed Value	`description`
198. Extension.extension:resultsByExposure.extension:description.value[x]
Definition	Human-readable summary of results by exposure state.
Short	Description of results by exposure
Type	string
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
200. Extension.extension:resultsByExposure.extension:exposureState
Slice Name	exposureState
Definition	Whether these results are for the exposure state or alternative exposure state.
Short	exposure \| exposure-alternative
Control	0..1
202. Extension.extension:resultsByExposure.extension:exposureState.url
Control	1..1
Fixed Value	`exposureState`
204. Extension.extension:resultsByExposure.extension:exposureState.value[x]
Definition	Whether these results are for the exposure state or alternative exposure state.
Short	exposure \| exposure-alternative
Binding	The codes SHALL be taken from R4_exposure_state_for_R4B (0.0.1-snapshot-2) (required to `http://hl7.org/fhir/4.0/ValueSet/R4-exposure-state-for-R4B\|0.0.1-snapshot-2`) Whether the results by exposure is describing the results for the primary exposure of interest (exposure) or the alternative state (exposureAlternative).
Type	code
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
206. Extension.extension:resultsByExposure.extension:variantState
Slice Name	variantState
Definition	Used to define variant exposure states such as low-risk state.
Short	Variant exposure states
Control	0..1
208. Extension.extension:resultsByExposure.extension:variantState.url
Control	1..1
Fixed Value	`variantState`
210. Extension.extension:resultsByExposure.extension:variantState.value[x]
Definition	Used to define variant exposure states such as low-risk state.
Short	Variant exposure states
Binding	Unless not suitable, these codes SHALL be taken from R4_evidence_variant_state_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-evidence-variant-state-for-R4B\|0.0.1-snapshot-2`) Used for results by exposure in variant states such as low-risk, medium-risk and high-risk states.
Type	CodeableConcept
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
212. Extension.extension:resultsByExposure.extension:riskEvidenceSynthesis
Slice Name	riskEvidenceSynthesis
Definition	Reference to a RiskEvidenceSynthesis resource.
Short	Risk evidence synthesis
Control	1..1
214. Extension.extension:resultsByExposure.extension:riskEvidenceSynthesis.url
Control	1..1
Fixed Value	`riskEvidenceSynthesis`
216. Extension.extension:resultsByExposure.extension:riskEvidenceSynthesis.value[x]
Definition	Reference to a RiskEvidenceSynthesis resource.
Short	Risk evidence synthesis
Type	Reference
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
218. Extension.extension:resultsByExposure.url
Control	1..1
Fixed Value	`resultsByExposure`
220. Extension.extension:effectEstimate
Slice Name	effectEstimate
Definition	The estimated effect of the exposure variant.
Short	What was the estimated effect
Control	0..*
222. Extension.extension:effectEstimate.extension
Control	0..*
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Closed, and can be differentiated using the following discriminators: value @ url
224. Extension.extension:effectEstimate.extension:description
Slice Name	description
Definition	Human-readable summary of effect estimate.
Short	Description of effect estimate
Control	0..1
226. Extension.extension:effectEstimate.extension:description.url
Control	1..1
Fixed Value	`description`
228. Extension.extension:effectEstimate.extension:description.value[x]
Definition	Human-readable summary of effect estimate.
Short	Description of effect estimate
Type	string
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
230. Extension.extension:effectEstimate.extension:type
Slice Name	type
Definition	Examples include relative risk and mean difference.
Short	Type of efffect estimate
Control	0..1
232. Extension.extension:effectEstimate.extension:type.url
Control	1..1
Fixed Value	`type`
234. Extension.extension:effectEstimate.extension:type.value[x]
Definition	Examples include relative risk and mean difference.
Short	Type of efffect estimate
Binding	Unless not suitable, these codes SHALL be taken from R4_effect_estimate_type_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-effect-estimate-type-for-R4B\|0.0.1-snapshot-2`) Whether the effect estimate is an absolute effect estimate (absolute difference) or a relative effect estimate (relative difference), and the specific type of effect estimate (eg relative risk or median difference).
Type	CodeableConcept
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
236. Extension.extension:effectEstimate.extension:variantState
Slice Name	variantState
Definition	Used to define variant exposure states such as low-risk state.
Short	Variant exposure states
Control	0..1
238. Extension.extension:effectEstimate.extension:variantState.url
Control	1..1
Fixed Value	`variantState`
240. Extension.extension:effectEstimate.extension:variantState.value[x]
Definition	Used to define variant exposure states such as low-risk state.
Short	Variant exposure states
Binding	Unless not suitable, these codes SHALL be taken from R4_evidence_variant_state_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-evidence-variant-state-for-R4B\|0.0.1-snapshot-2`) Used for results by exposure in variant states such as low-risk, medium-risk and high-risk states.
Type	CodeableConcept
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
242. Extension.extension:effectEstimate.extension:value
Slice Name	value
Definition	The point estimate of the effect estimate.
Short	Point estimate
Control	0..1
244. Extension.extension:effectEstimate.extension:value.url
Control	1..1
Fixed Value	`value`
246. Extension.extension:effectEstimate.extension:value.value[x]
Definition	The point estimate of the effect estimate.
Short	Point estimate
Type	decimal
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
248. Extension.extension:effectEstimate.extension:unitOfMeasure
Slice Name	unitOfMeasure
Definition	Specifies the UCUM unit for the outcome.
Short	What unit is the outcome described in?
Control	0..1
250. Extension.extension:effectEstimate.extension:unitOfMeasure.url
Control	1..1
Fixed Value	`unitOfMeasure`
252. Extension.extension:effectEstimate.extension:unitOfMeasure.value[x]
Definition	Specifies the UCUM unit for the outcome.
Short	What unit is the outcome described in?
Binding	The codes SHALL be taken from UCUMCodes (required to `http://hl7.org/fhir/ValueSet/ucum-units\|4.3.0`) Unified Code for Units of Measure (UCUM).
Type	CodeableConcept
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
254. Extension.extension:effectEstimate.extension:precisionEstimate
Slice Name	precisionEstimate
Definition	A description of the precision of the estimate for the effect.
Short	How precise the estimate is
Control	0..*
256. Extension.extension:effectEstimate.extension:precisionEstimate.extension
Control	0..*
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension`. The slices areUnordered and Closed, and can be differentiated using the following discriminators: value @ url
258. Extension.extension:effectEstimate.extension:precisionEstimate.extension:type
Slice Name	type
Definition	Examples include confidence interval and interquartile range.
Short	Type of precision estimate
Control	0..1
260. Extension.extension:effectEstimate.extension:precisionEstimate.extension:type.url
Control	1..1
Fixed Value	`type`
262. Extension.extension:effectEstimate.extension:precisionEstimate.extension:type.value[x]
Definition	Examples include confidence interval and interquartile range.
Short	Type of precision estimate
Binding	Unless not suitable, these codes SHALL be taken from R4_precision_estimate_type_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-precision-estimate-type-for-R4B\|0.0.1-snapshot-2`) Method of reporting variability of estimates, such as confidence intervals, interquartile range or standard deviation.
Type	CodeableConcept
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
264. Extension.extension:effectEstimate.extension:precisionEstimate.extension:level
Slice Name	level
Definition	Use 95 for a 95% confidence interval.
Short	Level of confidence interval
Control	0..1
266. Extension.extension:effectEstimate.extension:precisionEstimate.extension:level.url
Control	1..1
Fixed Value	`level`
268. Extension.extension:effectEstimate.extension:precisionEstimate.extension:level.value[x]
Definition	Use 95 for a 95% confidence interval.
Short	Level of confidence interval
Type	decimal
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
270. Extension.extension:effectEstimate.extension:precisionEstimate.extension:from
Slice Name	from
Definition	Lower bound of confidence interval.
Short	Lower bound
Control	0..1
272. Extension.extension:effectEstimate.extension:precisionEstimate.extension:from.url
Control	1..1
Fixed Value	`from`
274. Extension.extension:effectEstimate.extension:precisionEstimate.extension:from.value[x]
Definition	Lower bound of confidence interval.
Short	Lower bound
Type	decimal
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
276. Extension.extension:effectEstimate.extension:precisionEstimate.extension:to
Slice Name	to
Definition	Upper bound of confidence interval.
Short	Upper bound
Control	0..1
278. Extension.extension:effectEstimate.extension:precisionEstimate.extension:to.url
Control	1..1
Fixed Value	`to`
280. Extension.extension:effectEstimate.extension:precisionEstimate.extension:to.value[x]
Definition	Upper bound of confidence interval.
Short	Upper bound
Type	decimal
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
282. Extension.extension:effectEstimate.extension:precisionEstimate.url
Control	1..1
Fixed Value	`precisionEstimate`
284. Extension.extension:effectEstimate.url
Control	1..1
Fixed Value	`effectEstimate`
286. Extension.extension:certainty
Slice Name	certainty
Definition	A description of the certainty of the effect estimate.
Short	How certain is the effect
Control	0..*
288. Extension.extension:certainty.extension
Control	0..*
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Closed, and can be differentiated using the following discriminators: value @ url
290. Extension.extension:certainty.extension:rating
Slice Name	rating
Definition	A rating of the certainty of the effect estimate.
Short	Certainty rating
Control	0..*
292. Extension.extension:certainty.extension:rating.url
Control	1..1
Fixed Value	`rating`
294. Extension.extension:certainty.extension:rating.value[x]
Definition	A rating of the certainty of the effect estimate.
Short	Certainty rating
Binding	Unless not suitable, these codes SHALL be taken from R4_evidence_quality_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-evidence-quality-for-R4B\|0.0.1-snapshot-2`) The quality of the evidence described. The code system used specifies the quality scale used to grade this evidence source while the code specifies the actual quality score (represented as a coded value) associated with the evidence.
Type	CodeableConcept
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
296. Extension.extension:certainty.extension:note
Slice Name	note
Definition	A human-readable string to clarify or explain concepts about the resource.
Short	Used for footnotes or explanatory notes
Control	0..*
298. Extension.extension:certainty.extension:note.url
Control	1..1
Fixed Value	`note`
300. Extension.extension:certainty.extension:note.value[x]
Definition	A human-readable string to clarify or explain concepts about the resource.
Short	Used for footnotes or explanatory notes
Type	Annotation
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
302. Extension.extension:certainty.extension:certaintySubcomponent
Slice Name	certaintySubcomponent
Definition	A description of a component of the overall certainty.
Short	A component that contributes to the overall certainty
Control	0..*
304. Extension.extension:certainty.extension:certaintySubcomponent.extension
Control	0..*
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension`. The slices areUnordered and Closed, and can be differentiated using the following discriminators: value @ url
306. Extension.extension:certainty.extension:certaintySubcomponent.extension:type
Slice Name	type
Definition	This cross-version extension represents EffectEvidenceSynthesis.certainty.certaintySubcomponent.type from http://hl7.org/fhir/StructureDefinition/EffectEvidenceSynthesis\|4.0.1 for use in FHIR R4B.
Short	Type of subcomponent of certainty rating
Control	0..1
308. Extension.extension:certainty.extension:certaintySubcomponent.extension:type.url
Control	1..1
Fixed Value	`type`
310. Extension.extension:certainty.extension:certaintySubcomponent.extension:type.value[x]
Definition	This cross-version extension represents EffectEvidenceSynthesis.certainty.certaintySubcomponent.type from http://hl7.org/fhir/StructureDefinition/EffectEvidenceSynthesis\|4.0.1 for use in FHIR R4B.
Short	Type of subcomponent of certainty rating
Binding	Unless not suitable, these codes SHALL be taken from R4_certainty_subcomponent_type_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-certainty-subcomponent-type-for-R4B\|0.0.1-snapshot-2`) The subcomponent classification of quality of evidence rating systems.
Type	CodeableConcept
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
312. Extension.extension:certainty.extension:certaintySubcomponent.extension:rating
Slice Name	rating
Definition	A rating of a subcomponent of rating certainty.
Short	Subcomponent certainty rating
Control	0..*
314. Extension.extension:certainty.extension:certaintySubcomponent.extension:rating.url
Control	1..1
Fixed Value	`rating`
316. Extension.extension:certainty.extension:certaintySubcomponent.extension:rating.value[x]
Definition	A rating of a subcomponent of rating certainty.
Short	Subcomponent certainty rating
Binding	Unless not suitable, these codes SHALL be taken from R4_certainty_subcomponent_rating_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-certainty-subcomponent-rating-for-R4B\|0.0.1-snapshot-2`) The quality rating of the subcomponent of a quality of evidence rating.
Type	CodeableConcept
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
318. Extension.extension:certainty.extension:certaintySubcomponent.extension:note
Slice Name	note
Definition	A human-readable string to clarify or explain concepts about the resource.
Short	Used for footnotes or explanatory notes
Control	0..*
320. Extension.extension:certainty.extension:certaintySubcomponent.extension:note.url
Control	1..1
Fixed Value	`note`
322. Extension.extension:certainty.extension:certaintySubcomponent.extension:note.value[x]
Definition	A human-readable string to clarify or explain concepts about the resource.
Short	Used for footnotes or explanatory notes
Type	Annotation
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
324. Extension.extension:certainty.extension:certaintySubcomponent.url
Control	1..1
Fixed Value	`certaintySubcomponent`
326. Extension.extension:certainty.url
Control	1..1
Fixed Value	`certainty`
328. Extension.url
Control	1..1
Fixed Value	`http://hl7.org/fhir/4.0/StructureDefinition/extension-EffectEvidenceSynthesis`

Guidance on how to interpret the contents of this table can be foundhere

0. Extension
Definition	The EffectEvidenceSynthesis resource describes the difference in an outcome between exposures states in a population where the effect estimate is derived from a combination of research studies. Optional Extension Element - found in all resources.
Short	A quantified estimate of effect based on a body of evidenceOptional Extensions Element
Control	0..* This element is affected by the following invariants: ele-1
Is Modifier	false
Invariants	ele-1: All FHIR elements must have a @value or children unless an empty Parameters resource (`hasValue() or (children().count() > id.count()) or $this is Parameters`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children unless an empty Parameters resource (hasValue() or (children().count() > id.count()) or $this is Parameters) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
2. Extension.extension
Definition	An Extension May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	ExtensionAdditional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	50..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
Slicing	This element introduces a set of slices on `Extension.extension`. The slices areUnordered and ClosedOpen, and can be differentiated using the following discriminators: value @ url
4. Extension.extension:url
Slice Name	url
Definition	An absolute URI that is used to identify this effect evidence synthesis when it is referenced in a specification, model, design or an instance; also called its canonical identifier. This SHOULD be globally unique and SHOULD be a literal address at which at which an authoritative instance of this effect evidence synthesis is (or will be) published. This URL can be the target of a canonical reference. It SHALL remain the same when the effect evidence synthesis is stored on different servers.
Short	Canonical identifier for this effect evidence synthesis, represented as a URI (globally unique)Additional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
6. Extension.extension:url.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`url`
8. Extension.extension:url.value[x]
Definition	An absolute URI that is used to identify this effect evidence synthesis when it is referenced in a specification, model, design or an instance; also called its canonical identifier. This SHOULD be globally unique and SHOULD be a literal address at which at which an authoritative instance of this effect evidence synthesis is (or will be) published. This URL can be the target of a canonical reference. It SHALL remain the same when the effect evidence synthesis is stored on different servers. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Canonical identifier for this effect evidence synthesis, represented as a URI (globally unique)Value of extension
Control	0..1
Type	uri, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
10. Extension.extension:version
Slice Name	version
Definition	The identifier that is used to identify this version of the effect evidence synthesis when it is referenced in a specification, model, design or instance. This is an arbitrary value managed by the effect evidence synthesis author and is not expected to be globally unique. For example, it might be a timestamp (e.g. yyyymmdd) if a managed version is not available. There is also no expectation that versions can be placed in a lexicographical sequence.
Short	Business version of the effect evidence synthesisAdditional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
12. Extension.extension:version.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`version`
14. Extension.extension:version.value[x]
Definition	The identifier that is used to identify this version of the effect evidence synthesis when it is referenced in a specification, model, design or instance. This is an arbitrary value managed by the effect evidence synthesis author and is not expected to be globally unique. For example, it might be a timestamp (e.g. yyyymmdd) if a managed version is not available. There is also no expectation that versions can be placed in a lexicographical sequence. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Business version of the effect evidence synthesisValue of extension
Control	0..1
Type	string, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
16. Extension.extension:name
Slice Name	name
Definition	A natural language name identifying the effect evidence synthesis. This name should be usable as an identifier for the module by machine processing applications such as code generation.
Short	Name for this effect evidence synthesis (computer friendly)Additional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
18. Extension.extension:name.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`name`
20. Extension.extension:name.value[x]
Definition	A natural language name identifying the effect evidence synthesis. This name should be usable as an identifier for the module by machine processing applications such as code generation. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Name for this effect evidence synthesis (computer friendly)Value of extension
Control	0..1
Type	string, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
22. Extension.extension:title
Slice Name	title
Definition	A short, descriptive, user-friendly title for the effect evidence synthesis.
Short	Name for this effect evidence synthesis (human friendly)Additional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
24. Extension.extension:title.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`title`
26. Extension.extension:title.value[x]
Definition	A short, descriptive, user-friendly title for the effect evidence synthesis. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Name for this effect evidence synthesis (human friendly)Value of extension
Control	0..1
Type	string, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
28. Extension.extension:status
Slice Name	status
Definition	The status of this effect evidence synthesis. Enables tracking the life-cycle of the content.
Short	draft \| active \| retired \| unknownAdditional content defined by implementations
Control	10..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
30. Extension.extension:status.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`status`
32. Extension.extension:status.value[x]
Definition	The status of this effect evidence synthesis. Enables tracking the life-cycle of the content. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	draft \| active \| retired \| unknownValue of extension
Control	0..1
Binding	The codes SHALL be taken from For codes, see R4_publication_status_for_R4B (0.0.1-snapshot-2) (required to `http://hl7.org/fhir/4.0/ValueSet/R4-publication-status-for-R4B\|0.0.1-snapshot-2`) The lifecycle status of an artifact.
Type	code, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
34. Extension.extension:date
Slice Name	date
Definition	The date (and optionally time) when the effect evidence synthesis was published. The date must change when the business version changes and it must change if the status code changes. In addition, it should change when the substantive content of the effect evidence synthesis changes.
Short	Date last changedAdditional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
36. Extension.extension:date.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`date`
38. Extension.extension:date.value[x]
Definition	The date (and optionally time) when the effect evidence synthesis was published. The date must change when the business version changes and it must change if the status code changes. In addition, it should change when the substantive content of the effect evidence synthesis changes. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Date last changedValue of extension
Control	0..1
Type	dateTime, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
40. Extension.extension:publisher
Slice Name	publisher
Definition	The name of the organization or individual that published the effect evidence synthesis.
Short	Name of the publisher (organization or individual)Additional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
42. Extension.extension:publisher.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`publisher`
44. Extension.extension:publisher.value[x]
Definition	The name of the organization or individual that published the effect evidence synthesis. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Name of the publisher (organization or individual)Value of extension
Control	0..1
Type	string, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
46. Extension.extension:contact
Slice Name	contact
Definition	Contact details to assist a user in finding and communicating with the publisher.
Short	Contact details for the publisherAdditional content defined by implementations
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
48. Extension.extension:contact.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`contact`
50. Extension.extension:contact.value[x]
Definition	Contact details to assist a user in finding and communicating with the publisher. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Contact details for the publisherValue of extension
Control	0..1
Type	ContactDetail, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
52. Extension.extension:description
Slice Name	description
Definition	A free text natural language description of the effect evidence synthesis from a consumer's perspective.
Short	Natural language description of the effect evidence synthesisAdditional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
54. Extension.extension:description.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`description`
56. Extension.extension:description.value[x]
Definition	A free text natural language description of the effect evidence synthesis from a consumer's perspective. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Natural language description of the effect evidence synthesisValue of extension
Control	0..1
Type	markdown, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
58. Extension.extension:note
Slice Name	note
Definition	A human-readable string to clarify or explain concepts about the resource.
Short	Used for footnotes or explanatory notesAdditional content defined by implementations
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
60. Extension.extension:note.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`note`
62. Extension.extension:note.value[x]
Definition	A human-readable string to clarify or explain concepts about the resource. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Used for footnotes or explanatory notesValue of extension
Control	0..1
Type	Annotation, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
64. Extension.extension:useContext
Slice Name	useContext
Definition	The content was developed with a focus and intent of supporting the contexts that are listed. These contexts may be general categories (gender, age, ...) or may be references to specific programs (insurance plans, studies, ...) and may be used to assist with indexing and searching for appropriate effect evidence synthesis instances.
Short	The context that the content is intended to supportAdditional content defined by implementations
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
66. Extension.extension:useContext.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`useContext`
68. Extension.extension:useContext.value[x]
Definition	The content was developed with a focus and intent of supporting the contexts that are listed. These contexts may be general categories (gender, age, ...) or may be references to specific programs (insurance plans, studies, ...) and may be used to assist with indexing and searching for appropriate effect evidence synthesis instances. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	The context that the content is intended to supportValue of extension
Control	0..1
Type	UsageContext, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
70. Extension.extension:jurisdiction
Slice Name	jurisdiction
Definition	A legal or geographic region in which the effect evidence synthesis is intended to be used.
Short	Intended jurisdiction for effect evidence synthesis (if applicable)Additional content defined by implementations
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
72. Extension.extension:jurisdiction.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`jurisdiction`
74. Extension.extension:jurisdiction.value[x]
Definition	A legal or geographic region in which the effect evidence synthesis is intended to be used. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Intended jurisdiction for effect evidence synthesis (if applicable)Value of extension
Control	0..1
Binding	Unless not suitable, these codes SHALL be taken from For codes, see R4_jurisdiction_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-jurisdiction-for-R4B\|0.0.1-snapshot-2`) Countries and regions within which this artifact is targeted for use.
Type	CodeableConcept, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
76. Extension.extension:copyright
Slice Name	copyright
Definition	A copyright statement relating to the effect evidence synthesis and/or its contents. Copyright statements are generally legal restrictions on the use and publishing of the effect evidence synthesis.
Short	Use and/or publishing restrictionsAdditional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
78. Extension.extension:copyright.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`copyright`
80. Extension.extension:copyright.value[x]
Definition	A copyright statement relating to the effect evidence synthesis and/or its contents. Copyright statements are generally legal restrictions on the use and publishing of the effect evidence synthesis. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Use and/or publishing restrictionsValue of extension
Control	0..1
Type	markdown, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
82. Extension.extension:approvalDate
Slice Name	approvalDate
Definition	The date on which the resource content was approved by the publisher. Approval happens once when the content is officially approved for usage.
Short	When the effect evidence synthesis was approved by publisherAdditional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
84. Extension.extension:approvalDate.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`approvalDate`
86. Extension.extension:approvalDate.value[x]
Definition	The date on which the resource content was approved by the publisher. Approval happens once when the content is officially approved for usage. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	When the effect evidence synthesis was approved by publisherValue of extension
Control	0..1
Type	date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
88. Extension.extension:lastReviewDate
Slice Name	lastReviewDate
Definition	The date on which the resource content was last reviewed. Review happens periodically after approval but does not change the original approval date.
Short	When the effect evidence synthesis was last reviewedAdditional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
90. Extension.extension:lastReviewDate.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`lastReviewDate`
92. Extension.extension:lastReviewDate.value[x]
Definition	The date on which the resource content was last reviewed. Review happens periodically after approval but does not change the original approval date. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	When the effect evidence synthesis was last reviewedValue of extension
Control	0..1
Type	date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
94. Extension.extension:effectivePeriod
Slice Name	effectivePeriod
Definition	The period during which the effect evidence synthesis content was or is planned to be in active use.
Short	When the effect evidence synthesis is expected to be usedAdditional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
96. Extension.extension:effectivePeriod.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`effectivePeriod`
98. Extension.extension:effectivePeriod.value[x]
Definition	The period during which the effect evidence synthesis content was or is planned to be in active use. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	When the effect evidence synthesis is expected to be usedValue of extension
Control	0..1
Type	Period, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
100. Extension.extension:topic
Slice Name	topic
Definition	Descriptive topics related to the content of the EffectEvidenceSynthesis. Topics provide a high-level categorization grouping types of EffectEvidenceSynthesiss that can be useful for filtering and searching.
Short	The category of the EffectEvidenceSynthesis, such as Education, Treatment, Assessment, etc.Additional content defined by implementations
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
102. Extension.extension:topic.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`topic`
104. Extension.extension:topic.value[x]
Definition	Descriptive topics related to the content of the EffectEvidenceSynthesis. Topics provide a high-level categorization grouping types of EffectEvidenceSynthesiss that can be useful for filtering and searching. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	The category of the EffectEvidenceSynthesis, such as Education, Treatment, Assessment, etc.Value of extension
Control	0..1
Binding	For example codes, see For codes, see R4_definition_topic_for_R4B (0.0.1-snapshot-2) (example to `http://hl7.org/fhir/4.0/ValueSet/R4-definition-topic-for-R4B\|0.0.1-snapshot-2`) High-level categorization of the definition, used for searching, sorting, and filtering.
Type	CodeableConcept, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
106. Extension.extension:editor
Slice Name	editor
Definition	An individual or organization primarily responsible for internal coherence of the content.
Short	Who edited the contentAdditional content defined by implementations
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
108. Extension.extension:editor.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`editor`
110. Extension.extension:editor.value[x]
Definition	An individual or organization primarily responsible for internal coherence of the content. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Who edited the contentValue of extension
Control	0..1
Type	ContactDetail, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
112. Extension.extension:reviewer
Slice Name	reviewer
Definition	An individual or organization primarily responsible for review of some aspect of the content.
Short	Who reviewed the contentAdditional content defined by implementations
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
114. Extension.extension:reviewer.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`reviewer`
116. Extension.extension:reviewer.value[x]
Definition	An individual or organization primarily responsible for review of some aspect of the content. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Who reviewed the contentValue of extension
Control	0..1
Type	ContactDetail, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
118. Extension.extension:endorser
Slice Name	endorser
Definition	An individual or organization responsible for officially endorsing the content for use in some setting.
Short	Who endorsed the contentAdditional content defined by implementations
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
120. Extension.extension:endorser.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`endorser`
122. Extension.extension:endorser.value[x]
Definition	An individual or organization responsible for officially endorsing the content for use in some setting. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Who endorsed the contentValue of extension
Control	0..1
Type	ContactDetail, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
124. Extension.extension:relatedArtifact
Slice Name	relatedArtifact
Definition	Related artifacts such as additional documentation, justification, or bibliographic references.
Short	Additional documentation, citations, etc.Additional content defined by implementations
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
126. Extension.extension:relatedArtifact.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`relatedArtifact`
128. Extension.extension:relatedArtifact.value[x]
Definition	Related artifacts such as additional documentation, justification, or bibliographic references. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Additional documentation, citations, etc.Value of extension
Control	0..1
Type	RelatedArtifact, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
130. Extension.extension:synthesisType
Slice Name	synthesisType
Definition	Type of synthesis eg meta-analysis.
Short	Type of synthesisAdditional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
132. Extension.extension:synthesisType.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`synthesisType`
134. Extension.extension:synthesisType.value[x]
Definition	Type of synthesis eg meta-analysis. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Type of synthesisValue of extension
Control	0..1
Binding	Unless not suitable, these codes SHALL be taken from For codes, see SynthesisType (extensible to `http://hl7.org/fhir/ValueSet/synthesis-type\|4.3.0`) Types of combining results from a body of evidence (eg. summary data meta-analysis).
Type	CodeableConcept, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
136. Extension.extension:studyType
Slice Name	studyType
Definition	Type of study eg randomized trial.
Short	Type of studyAdditional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
138. Extension.extension:studyType.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`studyType`
140. Extension.extension:studyType.value[x]
Definition	Type of study eg randomized trial. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Type of studyValue of extension
Control	0..1
Binding	Unless not suitable, these codes SHALL be taken from For codes, see R4_study_type_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-study-type-for-R4B\|0.0.1-snapshot-2`) Types of research studies (types of research methods).
Type	CodeableConcept, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
142. Extension.extension:population
Slice Name	population
Definition	A reference to a EvidenceVariable resource that defines the population for the research.
Short	What population?Additional content defined by implementations
Control	10..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
144. Extension.extension:population.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`population`
146. Extension.extension:population.value[x]
Definition	A reference to a EvidenceVariable resource that defines the population for the research. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	What population?Value of extension
Control	0..1
Type	Reference, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
148. Extension.extension:exposure
Slice Name	exposure
Definition	A reference to a EvidenceVariable resource that defines the exposure for the research.
Short	What exposure?Additional content defined by implementations
Control	10..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
150. Extension.extension:exposure.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`exposure`
152. Extension.extension:exposure.value[x]
Definition	A reference to a EvidenceVariable resource that defines the exposure for the research. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	What exposure?Value of extension
Control	0..1
Type	Reference, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
154. Extension.extension:exposureAlternative
Slice Name	exposureAlternative
Definition	A reference to a EvidenceVariable resource that defines the comparison exposure for the research.
Short	What comparison exposure?Additional content defined by implementations
Control	10..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
156. Extension.extension:exposureAlternative.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`exposureAlternative`
158. Extension.extension:exposureAlternative.value[x]
Definition	A reference to a EvidenceVariable resource that defines the comparison exposure for the research. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	What comparison exposure?Value of extension
Control	0..1
Type	Reference, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
160. Extension.extension:outcome
Slice Name	outcome
Definition	A reference to a EvidenceVariable resomece that defines the outcome for the research.
Short	What outcome?Additional content defined by implementations
Control	10..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
162. Extension.extension:outcome.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`outcome`
164. Extension.extension:outcome.value[x]
Definition	A reference to a EvidenceVariable resomece that defines the outcome for the research. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	What outcome?Value of extension
Control	0..1
Type	Reference, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
166. Extension.extension:sampleSize
Slice Name	sampleSize
Definition	A description of the size of the sample involved in the synthesis.
Short	What sample size was involved?Additional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
168. Extension.extension:sampleSize.extension
Definition	An Extension May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	ExtensionAdditional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and ClosedOpen, and can be differentiated using the following discriminators: value @ url
170. Extension.extension:sampleSize.extension:description
Slice Name	description
Definition	Human-readable summary of sample size.
Short	Description of sample sizeAdditional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
172. Extension.extension:sampleSize.extension:description.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`description`
174. Extension.extension:sampleSize.extension:description.value[x]
Definition	Human-readable summary of sample size. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Description of sample sizeValue of extension
Control	0..1
Type	string, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
176. Extension.extension:sampleSize.extension:numberOfStudies
Slice Name	numberOfStudies
Definition	Number of studies included in this evidence synthesis.
Short	How many studies?Additional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
178. Extension.extension:sampleSize.extension:numberOfStudies.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`numberOfStudies`
180. Extension.extension:sampleSize.extension:numberOfStudies.value[x]
Definition	Number of studies included in this evidence synthesis. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	How many studies?Value of extension
Control	0..1
Type	integer, date, Address, Attachment, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
182. Extension.extension:sampleSize.extension:numberOfParticipants
Slice Name	numberOfParticipants
Definition	Number of participants included in this evidence synthesis.
Short	How many participants?Additional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
184. Extension.extension:sampleSize.extension:numberOfParticipants.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`numberOfParticipants`
186. Extension.extension:sampleSize.extension:numberOfParticipants.value[x]
Definition	Number of participants included in this evidence synthesis. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	How many participants?Value of extension
Control	0..1
Type	integer, date, Address, Attachment, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
188. Extension.extension:sampleSize.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`sampleSize`
190. Extension.extension:resultsByExposure
Slice Name	resultsByExposure
Definition	A description of the results for each exposure considered in the effect estimate.
Short	What was the result per exposure?Additional content defined by implementations
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
192. Extension.extension:resultsByExposure.extension
Definition	An Extension May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	ExtensionAdditional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	10..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and ClosedOpen, and can be differentiated using the following discriminators: value @ url
194. Extension.extension:resultsByExposure.extension:description
Slice Name	description
Definition	Human-readable summary of results by exposure state.
Short	Description of results by exposureAdditional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
196. Extension.extension:resultsByExposure.extension:description.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`description`
198. Extension.extension:resultsByExposure.extension:description.value[x]
Definition	Human-readable summary of results by exposure state. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Description of results by exposureValue of extension
Control	0..1
Type	string, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
200. Extension.extension:resultsByExposure.extension:exposureState
Slice Name	exposureState
Definition	Whether these results are for the exposure state or alternative exposure state.
Short	exposure \| exposure-alternativeAdditional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
202. Extension.extension:resultsByExposure.extension:exposureState.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`exposureState`
204. Extension.extension:resultsByExposure.extension:exposureState.value[x]
Definition	Whether these results are for the exposure state or alternative exposure state. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	exposure \| exposure-alternativeValue of extension
Control	0..1
Binding	The codes SHALL be taken from For codes, see R4_exposure_state_for_R4B (0.0.1-snapshot-2) (required to `http://hl7.org/fhir/4.0/ValueSet/R4-exposure-state-for-R4B\|0.0.1-snapshot-2`) Whether the results by exposure is describing the results for the primary exposure of interest (exposure) or the alternative state (exposureAlternative).
Type	code, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
206. Extension.extension:resultsByExposure.extension:variantState
Slice Name	variantState
Definition	Used to define variant exposure states such as low-risk state.
Short	Variant exposure statesAdditional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
208. Extension.extension:resultsByExposure.extension:variantState.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`variantState`
210. Extension.extension:resultsByExposure.extension:variantState.value[x]
Definition	Used to define variant exposure states such as low-risk state. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Variant exposure statesValue of extension
Control	0..1
Binding	Unless not suitable, these codes SHALL be taken from For codes, see R4_evidence_variant_state_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-evidence-variant-state-for-R4B\|0.0.1-snapshot-2`) Used for results by exposure in variant states such as low-risk, medium-risk and high-risk states.
Type	CodeableConcept, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
212. Extension.extension:resultsByExposure.extension:riskEvidenceSynthesis
Slice Name	riskEvidenceSynthesis
Definition	Reference to a RiskEvidenceSynthesis resource.
Short	Risk evidence synthesisAdditional content defined by implementations
Control	10..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
214. Extension.extension:resultsByExposure.extension:riskEvidenceSynthesis.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`riskEvidenceSynthesis`
216. Extension.extension:resultsByExposure.extension:riskEvidenceSynthesis.value[x]
Definition	Reference to a RiskEvidenceSynthesis resource. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Risk evidence synthesisValue of extension
Control	0..1
Type	Reference, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
218. Extension.extension:resultsByExposure.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`resultsByExposure`
220. Extension.extension:effectEstimate
Slice Name	effectEstimate
Definition	The estimated effect of the exposure variant.
Short	What was the estimated effectAdditional content defined by implementations
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
222. Extension.extension:effectEstimate.extension
Definition	An Extension May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	ExtensionAdditional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and ClosedOpen, and can be differentiated using the following discriminators: value @ url
224. Extension.extension:effectEstimate.extension:description
Slice Name	description
Definition	Human-readable summary of effect estimate.
Short	Description of effect estimateAdditional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
226. Extension.extension:effectEstimate.extension:description.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`description`
228. Extension.extension:effectEstimate.extension:description.value[x]
Definition	Human-readable summary of effect estimate. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Description of effect estimateValue of extension
Control	0..1
Type	string, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
230. Extension.extension:effectEstimate.extension:type
Slice Name	type
Definition	Examples include relative risk and mean difference.
Short	Type of efffect estimateAdditional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
232. Extension.extension:effectEstimate.extension:type.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`type`
234. Extension.extension:effectEstimate.extension:type.value[x]
Definition	Examples include relative risk and mean difference. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Type of efffect estimateValue of extension
Control	0..1
Binding	Unless not suitable, these codes SHALL be taken from For codes, see R4_effect_estimate_type_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-effect-estimate-type-for-R4B\|0.0.1-snapshot-2`) Whether the effect estimate is an absolute effect estimate (absolute difference) or a relative effect estimate (relative difference), and the specific type of effect estimate (eg relative risk or median difference).
Type	CodeableConcept, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
236. Extension.extension:effectEstimate.extension:variantState
Slice Name	variantState
Definition	Used to define variant exposure states such as low-risk state.
Short	Variant exposure statesAdditional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
238. Extension.extension:effectEstimate.extension:variantState.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`variantState`
240. Extension.extension:effectEstimate.extension:variantState.value[x]
Definition	Used to define variant exposure states such as low-risk state. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Variant exposure statesValue of extension
Control	0..1
Binding	Unless not suitable, these codes SHALL be taken from For codes, see R4_evidence_variant_state_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-evidence-variant-state-for-R4B\|0.0.1-snapshot-2`) Used for results by exposure in variant states such as low-risk, medium-risk and high-risk states.
Type	CodeableConcept, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
242. Extension.extension:effectEstimate.extension:value
Slice Name	value
Definition	The point estimate of the effect estimate.
Short	Point estimateAdditional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
244. Extension.extension:effectEstimate.extension:value.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`value`
246. Extension.extension:effectEstimate.extension:value.value[x]
Definition	The point estimate of the effect estimate. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Point estimateValue of extension
Control	0..1
Type	decimal, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, CodeableConcept, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
248. Extension.extension:effectEstimate.extension:unitOfMeasure
Slice Name	unitOfMeasure
Definition	Specifies the UCUM unit for the outcome.
Short	What unit is the outcome described in?Additional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
250. Extension.extension:effectEstimate.extension:unitOfMeasure.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`unitOfMeasure`
252. Extension.extension:effectEstimate.extension:unitOfMeasure.value[x]
Definition	Specifies the UCUM unit for the outcome. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	What unit is the outcome described in?Value of extension
Control	0..1
Binding	The codes SHALL be taken from For codes, see UCUMCodes (required to `http://hl7.org/fhir/ValueSet/ucum-units\|4.3.0`) Unified Code for Units of Measure (UCUM).
Type	CodeableConcept, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
254. Extension.extension:effectEstimate.extension:precisionEstimate
Slice Name	precisionEstimate
Definition	A description of the precision of the estimate for the effect.
Short	How precise the estimate isAdditional content defined by implementations
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
256. Extension.extension:effectEstimate.extension:precisionEstimate.extension
Definition	An Extension May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	ExtensionAdditional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension`. The slices areUnordered and ClosedOpen, and can be differentiated using the following discriminators: value @ url
258. Extension.extension:effectEstimate.extension:precisionEstimate.extension:type
Slice Name	type
Definition	Examples include confidence interval and interquartile range.
Short	Type of precision estimateAdditional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
260. Extension.extension:effectEstimate.extension:precisionEstimate.extension:type.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`type`
262. Extension.extension:effectEstimate.extension:precisionEstimate.extension:type.value[x]
Definition	Examples include confidence interval and interquartile range. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Type of precision estimateValue of extension
Control	0..1
Binding	Unless not suitable, these codes SHALL be taken from For codes, see R4_precision_estimate_type_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-precision-estimate-type-for-R4B\|0.0.1-snapshot-2`) Method of reporting variability of estimates, such as confidence intervals, interquartile range or standard deviation.
Type	CodeableConcept, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
264. Extension.extension:effectEstimate.extension:precisionEstimate.extension:level
Slice Name	level
Definition	Use 95 for a 95% confidence interval.
Short	Level of confidence intervalAdditional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
266. Extension.extension:effectEstimate.extension:precisionEstimate.extension:level.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`level`
268. Extension.extension:effectEstimate.extension:precisionEstimate.extension:level.value[x]
Definition	Use 95 for a 95% confidence interval. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Level of confidence intervalValue of extension
Control	0..1
Type	decimal, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, CodeableConcept, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
270. Extension.extension:effectEstimate.extension:precisionEstimate.extension:from
Slice Name	from
Definition	Lower bound of confidence interval.
Short	Lower boundAdditional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
272. Extension.extension:effectEstimate.extension:precisionEstimate.extension:from.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`from`
274. Extension.extension:effectEstimate.extension:precisionEstimate.extension:from.value[x]
Definition	Lower bound of confidence interval. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Lower boundValue of extension
Control	0..1
Type	decimal, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, CodeableConcept, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
276. Extension.extension:effectEstimate.extension:precisionEstimate.extension:to
Slice Name	to
Definition	Upper bound of confidence interval.
Short	Upper boundAdditional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
278. Extension.extension:effectEstimate.extension:precisionEstimate.extension:to.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`to`
280. Extension.extension:effectEstimate.extension:precisionEstimate.extension:to.value[x]
Definition	Upper bound of confidence interval. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Upper boundValue of extension
Control	0..1
Type	decimal, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, CodeableConcept, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
282. Extension.extension:effectEstimate.extension:precisionEstimate.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`precisionEstimate`
284. Extension.extension:effectEstimate.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`effectEstimate`
286. Extension.extension:certainty
Slice Name	certainty
Definition	A description of the certainty of the effect estimate.
Short	How certain is the effectAdditional content defined by implementations
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
288. Extension.extension:certainty.extension
Definition	An Extension May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	ExtensionAdditional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and ClosedOpen, and can be differentiated using the following discriminators: value @ url
290. Extension.extension:certainty.extension:rating
Slice Name	rating
Definition	A rating of the certainty of the effect estimate.
Short	Certainty ratingAdditional content defined by implementations
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
292. Extension.extension:certainty.extension:rating.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`rating`
294. Extension.extension:certainty.extension:rating.value[x]
Definition	A rating of the certainty of the effect estimate. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Certainty ratingValue of extension
Control	0..1
Binding	Unless not suitable, these codes SHALL be taken from For codes, see R4_evidence_quality_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-evidence-quality-for-R4B\|0.0.1-snapshot-2`) The quality of the evidence described. The code system used specifies the quality scale used to grade this evidence source while the code specifies the actual quality score (represented as a coded value) associated with the evidence.
Type	CodeableConcept, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
296. Extension.extension:certainty.extension:note
Slice Name	note
Definition	A human-readable string to clarify or explain concepts about the resource.
Short	Used for footnotes or explanatory notesAdditional content defined by implementations
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
298. Extension.extension:certainty.extension:note.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`note`
300. Extension.extension:certainty.extension:note.value[x]
Definition	A human-readable string to clarify or explain concepts about the resource. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Used for footnotes or explanatory notesValue of extension
Control	0..1
Type	Annotation, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
302. Extension.extension:certainty.extension:certaintySubcomponent
Slice Name	certaintySubcomponent
Definition	A description of a component of the overall certainty.
Short	A component that contributes to the overall certaintyAdditional content defined by implementations
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
304. Extension.extension:certainty.extension:certaintySubcomponent.extension
Definition	An Extension May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	ExtensionAdditional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension`. The slices areUnordered and ClosedOpen, and can be differentiated using the following discriminators: value @ url
306. Extension.extension:certainty.extension:certaintySubcomponent.extension:type
Slice Name	type
Definition	This cross-version extension represents EffectEvidenceSynthesis.certainty.certaintySubcomponent.type from http://hl7.org/fhir/StructureDefinition/EffectEvidenceSynthesis\|4.0.1 for use in FHIR R4B.
Short	Type of subcomponent of certainty ratingAdditional content defined by implementations
Control	0..1*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
308. Extension.extension:certainty.extension:certaintySubcomponent.extension:type.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`type`
310. Extension.extension:certainty.extension:certaintySubcomponent.extension:type.value[x]
Definition	This cross-version extension represents EffectEvidenceSynthesis.certainty.certaintySubcomponent.type from http://hl7.org/fhir/StructureDefinition/EffectEvidenceSynthesis\|4.0.1 for use in FHIR R4B. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Type of subcomponent of certainty ratingValue of extension
Control	0..1
Binding	Unless not suitable, these codes SHALL be taken from For codes, see R4_certainty_subcomponent_type_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-certainty-subcomponent-type-for-R4B\|0.0.1-snapshot-2`) The subcomponent classification of quality of evidence rating systems.
Type	CodeableConcept, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
312. Extension.extension:certainty.extension:certaintySubcomponent.extension:rating
Slice Name	rating
Definition	A rating of a subcomponent of rating certainty.
Short	Subcomponent certainty ratingAdditional content defined by implementations
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
314. Extension.extension:certainty.extension:certaintySubcomponent.extension:rating.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`rating`
316. Extension.extension:certainty.extension:certaintySubcomponent.extension:rating.value[x]
Definition	A rating of a subcomponent of rating certainty. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Subcomponent certainty ratingValue of extension
Control	0..1
Binding	Unless not suitable, these codes SHALL be taken from For codes, see R4_certainty_subcomponent_rating_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-certainty-subcomponent-rating-for-R4B\|0.0.1-snapshot-2`) The quality rating of the subcomponent of a quality of evidence rating.
Type	CodeableConcept, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
318. Extension.extension:certainty.extension:certaintySubcomponent.extension:note
Slice Name	note
Definition	A human-readable string to clarify or explain concepts about the resource.
Short	Used for footnotes or explanatory notesAdditional content defined by implementations
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count())) ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
320. Extension.extension:certainty.extension:certaintySubcomponent.extension:note.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`note`
322. Extension.extension:certainty.extension:certaintySubcomponent.extension:note.value[x]
Definition	A human-readable string to clarify or explain concepts about the resource. Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Used for footnotes or explanatory notesValue of extension
Control	0..1
Type	Annotation, date, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, CodeableConcept, ParameterDefinition, dateTime, code, string, Contributor, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
324. Extension.extension:certainty.extension:certaintySubcomponent.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`certaintySubcomponent`
326. Extension.extension:certainty.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`certainty`
328. Extension.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`http://hl7.org/fhir/4.0/StructureDefinition/extension-EffectEvidenceSynthesis`

Guidance on how to interpret the contents of this table can be foundhere

0. Extension
Definition	The EffectEvidenceSynthesis resource describes the difference in an outcome between exposures states in a population where the effect estimate is derived from a combination of research studies.
Short	A quantified estimate of effect based on a body of evidence
Control	0..* This element is affected by the following invariants: ele-1
Is Modifier	false
Invariants	ele-1: All FHIR elements must have a @value or children unless an empty Parameters resource (`hasValue() or (children().count() > id.count()) or $this is Parameters`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
2. Extension.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
4. Extension.extension
Definition	An Extension
Short	Extension
Control	5..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension`. The slices areUnordered and Closed, and can be differentiated using the following discriminators: value @ url
6. Extension.extension:url
Slice Name	url
Definition	An absolute URI that is used to identify this effect evidence synthesis when it is referenced in a specification, model, design or an instance; also called its canonical identifier. This SHOULD be globally unique and SHOULD be a literal address at which at which an authoritative instance of this effect evidence synthesis is (or will be) published. This URL can be the target of a canonical reference. It SHALL remain the same when the effect evidence synthesis is stored on different servers.
Short	Canonical identifier for this effect evidence synthesis, represented as a URI (globally unique)
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
8. Extension.extension:url.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
10. Extension.extension:url.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
12. Extension.extension:url.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`url`
14. Extension.extension:url.value[x]
Definition	An absolute URI that is used to identify this effect evidence synthesis when it is referenced in a specification, model, design or an instance; also called its canonical identifier. This SHOULD be globally unique and SHOULD be a literal address at which at which an authoritative instance of this effect evidence synthesis is (or will be) published. This URL can be the target of a canonical reference. It SHALL remain the same when the effect evidence synthesis is stored on different servers.
Short	Canonical identifier for this effect evidence synthesis, represented as a URI (globally unique)
Control	0..1
Type	uri
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
16. Extension.extension:version
Slice Name	version
Definition	The identifier that is used to identify this version of the effect evidence synthesis when it is referenced in a specification, model, design or instance. This is an arbitrary value managed by the effect evidence synthesis author and is not expected to be globally unique. For example, it might be a timestamp (e.g. yyyymmdd) if a managed version is not available. There is also no expectation that versions can be placed in a lexicographical sequence.
Short	Business version of the effect evidence synthesis
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
18. Extension.extension:version.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
20. Extension.extension:version.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
22. Extension.extension:version.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`version`
24. Extension.extension:version.value[x]
Definition	The identifier that is used to identify this version of the effect evidence synthesis when it is referenced in a specification, model, design or instance. This is an arbitrary value managed by the effect evidence synthesis author and is not expected to be globally unique. For example, it might be a timestamp (e.g. yyyymmdd) if a managed version is not available. There is also no expectation that versions can be placed in a lexicographical sequence.
Short	Business version of the effect evidence synthesis
Control	0..1
Type	string
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
26. Extension.extension:name
Slice Name	name
Definition	A natural language name identifying the effect evidence synthesis. This name should be usable as an identifier for the module by machine processing applications such as code generation.
Short	Name for this effect evidence synthesis (computer friendly)
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
28. Extension.extension:name.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
30. Extension.extension:name.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
32. Extension.extension:name.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`name`
34. Extension.extension:name.value[x]
Definition	A natural language name identifying the effect evidence synthesis. This name should be usable as an identifier for the module by machine processing applications such as code generation.
Short	Name for this effect evidence synthesis (computer friendly)
Control	0..1
Type	string
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
36. Extension.extension:title
Slice Name	title
Definition	A short, descriptive, user-friendly title for the effect evidence synthesis.
Short	Name for this effect evidence synthesis (human friendly)
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
38. Extension.extension:title.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
40. Extension.extension:title.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
42. Extension.extension:title.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`title`
44. Extension.extension:title.value[x]
Definition	A short, descriptive, user-friendly title for the effect evidence synthesis.
Short	Name for this effect evidence synthesis (human friendly)
Control	0..1
Type	string
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
46. Extension.extension:status
Slice Name	status
Definition	The status of this effect evidence synthesis. Enables tracking the life-cycle of the content.
Short	draft \| active \| retired \| unknown
Control	1..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
48. Extension.extension:status.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
50. Extension.extension:status.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
52. Extension.extension:status.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`status`
54. Extension.extension:status.value[x]
Definition	The status of this effect evidence synthesis. Enables tracking the life-cycle of the content.
Short	draft \| active \| retired \| unknown
Control	0..1
Binding	The codes SHALL be taken from R4_publication_status_for_R4B (0.0.1-snapshot-2) (required to `http://hl7.org/fhir/4.0/ValueSet/R4-publication-status-for-R4B\|0.0.1-snapshot-2`) The lifecycle status of an artifact.
Type	code
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
56. Extension.extension:date
Slice Name	date
Definition	The date (and optionally time) when the effect evidence synthesis was published. The date must change when the business version changes and it must change if the status code changes. In addition, it should change when the substantive content of the effect evidence synthesis changes.
Short	Date last changed
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
58. Extension.extension:date.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
60. Extension.extension:date.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
62. Extension.extension:date.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`date`
64. Extension.extension:date.value[x]
Definition	The date (and optionally time) when the effect evidence synthesis was published. The date must change when the business version changes and it must change if the status code changes. In addition, it should change when the substantive content of the effect evidence synthesis changes.
Short	Date last changed
Control	0..1
Type	dateTime
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
66. Extension.extension:publisher
Slice Name	publisher
Definition	The name of the organization or individual that published the effect evidence synthesis.
Short	Name of the publisher (organization or individual)
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
68. Extension.extension:publisher.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
70. Extension.extension:publisher.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
72. Extension.extension:publisher.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`publisher`
74. Extension.extension:publisher.value[x]
Definition	The name of the organization or individual that published the effect evidence synthesis.
Short	Name of the publisher (organization or individual)
Control	0..1
Type	string
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
76. Extension.extension:contact
Slice Name	contact
Definition	Contact details to assist a user in finding and communicating with the publisher.
Short	Contact details for the publisher
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
78. Extension.extension:contact.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
80. Extension.extension:contact.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
82. Extension.extension:contact.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`contact`
84. Extension.extension:contact.value[x]
Definition	Contact details to assist a user in finding and communicating with the publisher.
Short	Contact details for the publisher
Control	0..1
Type	ContactDetail
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
86. Extension.extension:description
Slice Name	description
Definition	A free text natural language description of the effect evidence synthesis from a consumer's perspective.
Short	Natural language description of the effect evidence synthesis
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
88. Extension.extension:description.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
90. Extension.extension:description.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
92. Extension.extension:description.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`description`
94. Extension.extension:description.value[x]
Definition	A free text natural language description of the effect evidence synthesis from a consumer's perspective.
Short	Natural language description of the effect evidence synthesis
Control	0..1
Type	markdown
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
96. Extension.extension:note
Slice Name	note
Definition	A human-readable string to clarify or explain concepts about the resource.
Short	Used for footnotes or explanatory notes
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
98. Extension.extension:note.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
100. Extension.extension:note.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
102. Extension.extension:note.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`note`
104. Extension.extension:note.value[x]
Definition	A human-readable string to clarify or explain concepts about the resource.
Short	Used for footnotes or explanatory notes
Control	0..1
Type	Annotation
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
106. Extension.extension:useContext
Slice Name	useContext
Definition	The content was developed with a focus and intent of supporting the contexts that are listed. These contexts may be general categories (gender, age, ...) or may be references to specific programs (insurance plans, studies, ...) and may be used to assist with indexing and searching for appropriate effect evidence synthesis instances.
Short	The context that the content is intended to support
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
108. Extension.extension:useContext.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
110. Extension.extension:useContext.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
112. Extension.extension:useContext.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`useContext`
114. Extension.extension:useContext.value[x]
Definition	The content was developed with a focus and intent of supporting the contexts that are listed. These contexts may be general categories (gender, age, ...) or may be references to specific programs (insurance plans, studies, ...) and may be used to assist with indexing and searching for appropriate effect evidence synthesis instances.
Short	The context that the content is intended to support
Control	0..1
Type	UsageContext
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
116. Extension.extension:jurisdiction
Slice Name	jurisdiction
Definition	A legal or geographic region in which the effect evidence synthesis is intended to be used.
Short	Intended jurisdiction for effect evidence synthesis (if applicable)
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
118. Extension.extension:jurisdiction.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
120. Extension.extension:jurisdiction.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
122. Extension.extension:jurisdiction.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`jurisdiction`
124. Extension.extension:jurisdiction.value[x]
Definition	A legal or geographic region in which the effect evidence synthesis is intended to be used.
Short	Intended jurisdiction for effect evidence synthesis (if applicable)
Control	0..1
Binding	Unless not suitable, these codes SHALL be taken from R4_jurisdiction_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-jurisdiction-for-R4B\|0.0.1-snapshot-2`) Countries and regions within which this artifact is targeted for use.
Type	CodeableConcept
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
126. Extension.extension:copyright
Slice Name	copyright
Definition	A copyright statement relating to the effect evidence synthesis and/or its contents. Copyright statements are generally legal restrictions on the use and publishing of the effect evidence synthesis.
Short	Use and/or publishing restrictions
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
128. Extension.extension:copyright.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
130. Extension.extension:copyright.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
132. Extension.extension:copyright.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`copyright`
134. Extension.extension:copyright.value[x]
Definition	A copyright statement relating to the effect evidence synthesis and/or its contents. Copyright statements are generally legal restrictions on the use and publishing of the effect evidence synthesis.
Short	Use and/or publishing restrictions
Control	0..1
Type	markdown
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
136. Extension.extension:approvalDate
Slice Name	approvalDate
Definition	The date on which the resource content was approved by the publisher. Approval happens once when the content is officially approved for usage.
Short	When the effect evidence synthesis was approved by publisher
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
138. Extension.extension:approvalDate.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
140. Extension.extension:approvalDate.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
142. Extension.extension:approvalDate.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`approvalDate`
144. Extension.extension:approvalDate.value[x]
Definition	The date on which the resource content was approved by the publisher. Approval happens once when the content is officially approved for usage.
Short	When the effect evidence synthesis was approved by publisher
Control	0..1
Type	date
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
146. Extension.extension:lastReviewDate
Slice Name	lastReviewDate
Definition	The date on which the resource content was last reviewed. Review happens periodically after approval but does not change the original approval date.
Short	When the effect evidence synthesis was last reviewed
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
148. Extension.extension:lastReviewDate.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
150. Extension.extension:lastReviewDate.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
152. Extension.extension:lastReviewDate.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`lastReviewDate`
154. Extension.extension:lastReviewDate.value[x]
Definition	The date on which the resource content was last reviewed. Review happens periodically after approval but does not change the original approval date.
Short	When the effect evidence synthesis was last reviewed
Control	0..1
Type	date
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
156. Extension.extension:effectivePeriod
Slice Name	effectivePeriod
Definition	The period during which the effect evidence synthesis content was or is planned to be in active use.
Short	When the effect evidence synthesis is expected to be used
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
158. Extension.extension:effectivePeriod.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
160. Extension.extension:effectivePeriod.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
162. Extension.extension:effectivePeriod.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`effectivePeriod`
164. Extension.extension:effectivePeriod.value[x]
Definition	The period during which the effect evidence synthesis content was or is planned to be in active use.
Short	When the effect evidence synthesis is expected to be used
Control	0..1
Type	Period
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
166. Extension.extension:topic
Slice Name	topic
Definition	Descriptive topics related to the content of the EffectEvidenceSynthesis. Topics provide a high-level categorization grouping types of EffectEvidenceSynthesiss that can be useful for filtering and searching.
Short	The category of the EffectEvidenceSynthesis, such as Education, Treatment, Assessment, etc.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
168. Extension.extension:topic.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
170. Extension.extension:topic.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
172. Extension.extension:topic.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`topic`
174. Extension.extension:topic.value[x]
Definition	Descriptive topics related to the content of the EffectEvidenceSynthesis. Topics provide a high-level categorization grouping types of EffectEvidenceSynthesiss that can be useful for filtering and searching.
Short	The category of the EffectEvidenceSynthesis, such as Education, Treatment, Assessment, etc.
Control	0..1
Binding	For example codes, see R4_definition_topic_for_R4B (0.0.1-snapshot-2) (example to `http://hl7.org/fhir/4.0/ValueSet/R4-definition-topic-for-R4B\|0.0.1-snapshot-2`) High-level categorization of the definition, used for searching, sorting, and filtering.
Type	CodeableConcept
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
176. Extension.extension:editor
Slice Name	editor
Definition	An individual or organization primarily responsible for internal coherence of the content.
Short	Who edited the content
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
178. Extension.extension:editor.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
180. Extension.extension:editor.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
182. Extension.extension:editor.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`editor`
184. Extension.extension:editor.value[x]
Definition	An individual or organization primarily responsible for internal coherence of the content.
Short	Who edited the content
Control	0..1
Type	ContactDetail
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
186. Extension.extension:reviewer
Slice Name	reviewer
Definition	An individual or organization primarily responsible for review of some aspect of the content.
Short	Who reviewed the content
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
188. Extension.extension:reviewer.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
190. Extension.extension:reviewer.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
192. Extension.extension:reviewer.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`reviewer`
194. Extension.extension:reviewer.value[x]
Definition	An individual or organization primarily responsible for review of some aspect of the content.
Short	Who reviewed the content
Control	0..1
Type	ContactDetail
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
196. Extension.extension:endorser
Slice Name	endorser
Definition	An individual or organization responsible for officially endorsing the content for use in some setting.
Short	Who endorsed the content
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
198. Extension.extension:endorser.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
200. Extension.extension:endorser.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
202. Extension.extension:endorser.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`endorser`
204. Extension.extension:endorser.value[x]
Definition	An individual or organization responsible for officially endorsing the content for use in some setting.
Short	Who endorsed the content
Control	0..1
Type	ContactDetail
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
206. Extension.extension:relatedArtifact
Slice Name	relatedArtifact
Definition	Related artifacts such as additional documentation, justification, or bibliographic references.
Short	Additional documentation, citations, etc.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
208. Extension.extension:relatedArtifact.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
210. Extension.extension:relatedArtifact.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
212. Extension.extension:relatedArtifact.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`relatedArtifact`
214. Extension.extension:relatedArtifact.value[x]
Definition	Related artifacts such as additional documentation, justification, or bibliographic references.
Short	Additional documentation, citations, etc.
Control	0..1
Type	RelatedArtifact
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
216. Extension.extension:synthesisType
Slice Name	synthesisType
Definition	Type of synthesis eg meta-analysis.
Short	Type of synthesis
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
218. Extension.extension:synthesisType.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
220. Extension.extension:synthesisType.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
222. Extension.extension:synthesisType.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`synthesisType`
224. Extension.extension:synthesisType.value[x]
Definition	Type of synthesis eg meta-analysis.
Short	Type of synthesis
Control	0..1
Binding	Unless not suitable, these codes SHALL be taken from SynthesisType (extensible to `http://hl7.org/fhir/ValueSet/synthesis-type\|4.3.0`) Types of combining results from a body of evidence (eg. summary data meta-analysis).
Type	CodeableConcept
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
226. Extension.extension:studyType
Slice Name	studyType
Definition	Type of study eg randomized trial.
Short	Type of study
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
228. Extension.extension:studyType.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
230. Extension.extension:studyType.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
232. Extension.extension:studyType.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`studyType`
234. Extension.extension:studyType.value[x]
Definition	Type of study eg randomized trial.
Short	Type of study
Control	0..1
Binding	Unless not suitable, these codes SHALL be taken from R4_study_type_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-study-type-for-R4B\|0.0.1-snapshot-2`) Types of research studies (types of research methods).
Type	CodeableConcept
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
236. Extension.extension:population
Slice Name	population
Definition	A reference to a EvidenceVariable resource that defines the population for the research.
Short	What population?
Control	1..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
238. Extension.extension:population.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
240. Extension.extension:population.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
242. Extension.extension:population.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`population`
244. Extension.extension:population.value[x]
Definition	A reference to a EvidenceVariable resource that defines the population for the research.
Short	What population?
Control	0..1
Type	Reference
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
246. Extension.extension:exposure
Slice Name	exposure
Definition	A reference to a EvidenceVariable resource that defines the exposure for the research.
Short	What exposure?
Control	1..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
248. Extension.extension:exposure.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
250. Extension.extension:exposure.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
252. Extension.extension:exposure.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`exposure`
254. Extension.extension:exposure.value[x]
Definition	A reference to a EvidenceVariable resource that defines the exposure for the research.
Short	What exposure?
Control	0..1
Type	Reference
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
256. Extension.extension:exposureAlternative
Slice Name	exposureAlternative
Definition	A reference to a EvidenceVariable resource that defines the comparison exposure for the research.
Short	What comparison exposure?
Control	1..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
258. Extension.extension:exposureAlternative.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
260. Extension.extension:exposureAlternative.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
262. Extension.extension:exposureAlternative.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`exposureAlternative`
264. Extension.extension:exposureAlternative.value[x]
Definition	A reference to a EvidenceVariable resource that defines the comparison exposure for the research.
Short	What comparison exposure?
Control	0..1
Type	Reference
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
266. Extension.extension:outcome
Slice Name	outcome
Definition	A reference to a EvidenceVariable resomece that defines the outcome for the research.
Short	What outcome?
Control	1..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
268. Extension.extension:outcome.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
270. Extension.extension:outcome.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
272. Extension.extension:outcome.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`outcome`
274. Extension.extension:outcome.value[x]
Definition	A reference to a EvidenceVariable resomece that defines the outcome for the research.
Short	What outcome?
Control	0..1
Type	Reference
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
276. Extension.extension:sampleSize
Slice Name	sampleSize
Definition	A description of the size of the sample involved in the synthesis.
Short	What sample size was involved?
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
278. Extension.extension:sampleSize.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
280. Extension.extension:sampleSize.extension
Definition	An Extension
Short	Extension
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Closed, and can be differentiated using the following discriminators: value @ url
282. Extension.extension:sampleSize.extension:description
Slice Name	description
Definition	Human-readable summary of sample size.
Short	Description of sample size
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
284. Extension.extension:sampleSize.extension:description.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
286. Extension.extension:sampleSize.extension:description.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
288. Extension.extension:sampleSize.extension:description.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`description`
290. Extension.extension:sampleSize.extension:description.value[x]
Definition	Human-readable summary of sample size.
Short	Description of sample size
Control	0..1
Type	string
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
292. Extension.extension:sampleSize.extension:numberOfStudies
Slice Name	numberOfStudies
Definition	Number of studies included in this evidence synthesis.
Short	How many studies?
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
294. Extension.extension:sampleSize.extension:numberOfStudies.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
296. Extension.extension:sampleSize.extension:numberOfStudies.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
298. Extension.extension:sampleSize.extension:numberOfStudies.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`numberOfStudies`
300. Extension.extension:sampleSize.extension:numberOfStudies.value[x]
Definition	Number of studies included in this evidence synthesis.
Short	How many studies?
Control	0..1
Type	integer
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
302. Extension.extension:sampleSize.extension:numberOfParticipants
Slice Name	numberOfParticipants
Definition	Number of participants included in this evidence synthesis.
Short	How many participants?
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
304. Extension.extension:sampleSize.extension:numberOfParticipants.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
306. Extension.extension:sampleSize.extension:numberOfParticipants.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
308. Extension.extension:sampleSize.extension:numberOfParticipants.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`numberOfParticipants`
310. Extension.extension:sampleSize.extension:numberOfParticipants.value[x]
Definition	Number of participants included in this evidence synthesis.
Short	How many participants?
Control	0..1
Type	integer
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
312. Extension.extension:sampleSize.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`sampleSize`
314. Extension.extension:sampleSize.value[x]
Definition	Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Value of extension
Control	0..1
Type	Choice of: base64Binary, boolean, canonical, code, date, dateTime, decimal, id, instant, integer, markdown, oid, positiveInt, string, time, unsignedInt, uri, url, uuid, Address, Age, Annotation, Attachment, CodeableConcept, CodeableReference, Coding, ContactPoint, Count, Distance, Duration, HumanName, Identifier, Money, Period, Quantity, Range, Ratio, RatioRange, Reference, SampledData, Signature, Timing, ContactDetail, Contributor, DataRequirement, Expression, ParameterDefinition, RelatedArtifact, TriggerDefinition, UsageContext, Dosage
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
316. Extension.extension:resultsByExposure
Slice Name	resultsByExposure
Definition	A description of the results for each exposure considered in the effect estimate.
Short	What was the result per exposure?
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
318. Extension.extension:resultsByExposure.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
320. Extension.extension:resultsByExposure.extension
Definition	An Extension
Short	Extension
Control	1..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Closed, and can be differentiated using the following discriminators: value @ url
322. Extension.extension:resultsByExposure.extension:description
Slice Name	description
Definition	Human-readable summary of results by exposure state.
Short	Description of results by exposure
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
324. Extension.extension:resultsByExposure.extension:description.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
326. Extension.extension:resultsByExposure.extension:description.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
328. Extension.extension:resultsByExposure.extension:description.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`description`
330. Extension.extension:resultsByExposure.extension:description.value[x]
Definition	Human-readable summary of results by exposure state.
Short	Description of results by exposure
Control	0..1
Type	string
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
332. Extension.extension:resultsByExposure.extension:exposureState
Slice Name	exposureState
Definition	Whether these results are for the exposure state or alternative exposure state.
Short	exposure \| exposure-alternative
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
334. Extension.extension:resultsByExposure.extension:exposureState.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
336. Extension.extension:resultsByExposure.extension:exposureState.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
338. Extension.extension:resultsByExposure.extension:exposureState.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`exposureState`
340. Extension.extension:resultsByExposure.extension:exposureState.value[x]
Definition	Whether these results are for the exposure state or alternative exposure state.
Short	exposure \| exposure-alternative
Control	0..1
Binding	The codes SHALL be taken from R4_exposure_state_for_R4B (0.0.1-snapshot-2) (required to `http://hl7.org/fhir/4.0/ValueSet/R4-exposure-state-for-R4B\|0.0.1-snapshot-2`) Whether the results by exposure is describing the results for the primary exposure of interest (exposure) or the alternative state (exposureAlternative).
Type	code
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
342. Extension.extension:resultsByExposure.extension:variantState
Slice Name	variantState
Definition	Used to define variant exposure states such as low-risk state.
Short	Variant exposure states
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
344. Extension.extension:resultsByExposure.extension:variantState.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
346. Extension.extension:resultsByExposure.extension:variantState.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
348. Extension.extension:resultsByExposure.extension:variantState.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`variantState`
350. Extension.extension:resultsByExposure.extension:variantState.value[x]
Definition	Used to define variant exposure states such as low-risk state.
Short	Variant exposure states
Control	0..1
Binding	Unless not suitable, these codes SHALL be taken from R4_evidence_variant_state_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-evidence-variant-state-for-R4B\|0.0.1-snapshot-2`) Used for results by exposure in variant states such as low-risk, medium-risk and high-risk states.
Type	CodeableConcept
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
352. Extension.extension:resultsByExposure.extension:riskEvidenceSynthesis
Slice Name	riskEvidenceSynthesis
Definition	Reference to a RiskEvidenceSynthesis resource.
Short	Risk evidence synthesis
Control	1..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
354. Extension.extension:resultsByExposure.extension:riskEvidenceSynthesis.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
356. Extension.extension:resultsByExposure.extension:riskEvidenceSynthesis.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
358. Extension.extension:resultsByExposure.extension:riskEvidenceSynthesis.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`riskEvidenceSynthesis`
360. Extension.extension:resultsByExposure.extension:riskEvidenceSynthesis.value[x]
Definition	Reference to a RiskEvidenceSynthesis resource.
Short	Risk evidence synthesis
Control	0..1
Type	Reference
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
362. Extension.extension:resultsByExposure.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`resultsByExposure`
364. Extension.extension:resultsByExposure.value[x]
Definition	Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Value of extension
Control	0..1
Type	Choice of: base64Binary, boolean, canonical, code, date, dateTime, decimal, id, instant, integer, markdown, oid, positiveInt, string, time, unsignedInt, uri, url, uuid, Address, Age, Annotation, Attachment, CodeableConcept, CodeableReference, Coding, ContactPoint, Count, Distance, Duration, HumanName, Identifier, Money, Period, Quantity, Range, Ratio, RatioRange, Reference, SampledData, Signature, Timing, ContactDetail, Contributor, DataRequirement, Expression, ParameterDefinition, RelatedArtifact, TriggerDefinition, UsageContext, Dosage
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
366. Extension.extension:effectEstimate
Slice Name	effectEstimate
Definition	The estimated effect of the exposure variant.
Short	What was the estimated effect
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
368. Extension.extension:effectEstimate.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
370. Extension.extension:effectEstimate.extension
Definition	An Extension
Short	Extension
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Closed, and can be differentiated using the following discriminators: value @ url
372. Extension.extension:effectEstimate.extension:description
Slice Name	description
Definition	Human-readable summary of effect estimate.
Short	Description of effect estimate
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
374. Extension.extension:effectEstimate.extension:description.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
376. Extension.extension:effectEstimate.extension:description.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
378. Extension.extension:effectEstimate.extension:description.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`description`
380. Extension.extension:effectEstimate.extension:description.value[x]
Definition	Human-readable summary of effect estimate.
Short	Description of effect estimate
Control	0..1
Type	string
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
382. Extension.extension:effectEstimate.extension:type
Slice Name	type
Definition	Examples include relative risk and mean difference.
Short	Type of efffect estimate
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
384. Extension.extension:effectEstimate.extension:type.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
386. Extension.extension:effectEstimate.extension:type.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
388. Extension.extension:effectEstimate.extension:type.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`type`
390. Extension.extension:effectEstimate.extension:type.value[x]
Definition	Examples include relative risk and mean difference.
Short	Type of efffect estimate
Control	0..1
Binding	Unless not suitable, these codes SHALL be taken from R4_effect_estimate_type_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-effect-estimate-type-for-R4B\|0.0.1-snapshot-2`) Whether the effect estimate is an absolute effect estimate (absolute difference) or a relative effect estimate (relative difference), and the specific type of effect estimate (eg relative risk or median difference).
Type	CodeableConcept
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
392. Extension.extension:effectEstimate.extension:variantState
Slice Name	variantState
Definition	Used to define variant exposure states such as low-risk state.
Short	Variant exposure states
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
394. Extension.extension:effectEstimate.extension:variantState.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
396. Extension.extension:effectEstimate.extension:variantState.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
398. Extension.extension:effectEstimate.extension:variantState.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`variantState`
400. Extension.extension:effectEstimate.extension:variantState.value[x]
Definition	Used to define variant exposure states such as low-risk state.
Short	Variant exposure states
Control	0..1
Binding	Unless not suitable, these codes SHALL be taken from R4_evidence_variant_state_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-evidence-variant-state-for-R4B\|0.0.1-snapshot-2`) Used for results by exposure in variant states such as low-risk, medium-risk and high-risk states.
Type	CodeableConcept
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
402. Extension.extension:effectEstimate.extension:value
Slice Name	value
Definition	The point estimate of the effect estimate.
Short	Point estimate
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
404. Extension.extension:effectEstimate.extension:value.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
406. Extension.extension:effectEstimate.extension:value.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
408. Extension.extension:effectEstimate.extension:value.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`value`
410. Extension.extension:effectEstimate.extension:value.value[x]
Definition	The point estimate of the effect estimate.
Short	Point estimate
Control	0..1
Type	decimal
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
412. Extension.extension:effectEstimate.extension:unitOfMeasure
Slice Name	unitOfMeasure
Definition	Specifies the UCUM unit for the outcome.
Short	What unit is the outcome described in?
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
414. Extension.extension:effectEstimate.extension:unitOfMeasure.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
416. Extension.extension:effectEstimate.extension:unitOfMeasure.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
418. Extension.extension:effectEstimate.extension:unitOfMeasure.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`unitOfMeasure`
420. Extension.extension:effectEstimate.extension:unitOfMeasure.value[x]
Definition	Specifies the UCUM unit for the outcome.
Short	What unit is the outcome described in?
Control	0..1
Binding	The codes SHALL be taken from UCUMCodes (required to `http://hl7.org/fhir/ValueSet/ucum-units\|4.3.0`) Unified Code for Units of Measure (UCUM).
Type	CodeableConcept
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
422. Extension.extension:effectEstimate.extension:precisionEstimate
Slice Name	precisionEstimate
Definition	A description of the precision of the estimate for the effect.
Short	How precise the estimate is
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
424. Extension.extension:effectEstimate.extension:precisionEstimate.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
426. Extension.extension:effectEstimate.extension:precisionEstimate.extension
Definition	An Extension
Short	Extension
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension`. The slices areUnordered and Closed, and can be differentiated using the following discriminators: value @ url
428. Extension.extension:effectEstimate.extension:precisionEstimate.extension:type
Slice Name	type
Definition	Examples include confidence interval and interquartile range.
Short	Type of precision estimate
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
430. Extension.extension:effectEstimate.extension:precisionEstimate.extension:type.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
432. Extension.extension:effectEstimate.extension:precisionEstimate.extension:type.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
434. Extension.extension:effectEstimate.extension:precisionEstimate.extension:type.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`type`
436. Extension.extension:effectEstimate.extension:precisionEstimate.extension:type.value[x]
Definition	Examples include confidence interval and interquartile range.
Short	Type of precision estimate
Control	0..1
Binding	Unless not suitable, these codes SHALL be taken from R4_precision_estimate_type_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-precision-estimate-type-for-R4B\|0.0.1-snapshot-2`) Method of reporting variability of estimates, such as confidence intervals, interquartile range or standard deviation.
Type	CodeableConcept
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
438. Extension.extension:effectEstimate.extension:precisionEstimate.extension:level
Slice Name	level
Definition	Use 95 for a 95% confidence interval.
Short	Level of confidence interval
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
440. Extension.extension:effectEstimate.extension:precisionEstimate.extension:level.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
442. Extension.extension:effectEstimate.extension:precisionEstimate.extension:level.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
444. Extension.extension:effectEstimate.extension:precisionEstimate.extension:level.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`level`
446. Extension.extension:effectEstimate.extension:precisionEstimate.extension:level.value[x]
Definition	Use 95 for a 95% confidence interval.
Short	Level of confidence interval
Control	0..1
Type	decimal
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
448. Extension.extension:effectEstimate.extension:precisionEstimate.extension:from
Slice Name	from
Definition	Lower bound of confidence interval.
Short	Lower bound
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
450. Extension.extension:effectEstimate.extension:precisionEstimate.extension:from.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
452. Extension.extension:effectEstimate.extension:precisionEstimate.extension:from.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
454. Extension.extension:effectEstimate.extension:precisionEstimate.extension:from.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`from`
456. Extension.extension:effectEstimate.extension:precisionEstimate.extension:from.value[x]
Definition	Lower bound of confidence interval.
Short	Lower bound
Control	0..1
Type	decimal
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
458. Extension.extension:effectEstimate.extension:precisionEstimate.extension:to
Slice Name	to
Definition	Upper bound of confidence interval.
Short	Upper bound
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
460. Extension.extension:effectEstimate.extension:precisionEstimate.extension:to.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
462. Extension.extension:effectEstimate.extension:precisionEstimate.extension:to.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
464. Extension.extension:effectEstimate.extension:precisionEstimate.extension:to.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`to`
466. Extension.extension:effectEstimate.extension:precisionEstimate.extension:to.value[x]
Definition	Upper bound of confidence interval.
Short	Upper bound
Control	0..1
Type	decimal
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
468. Extension.extension:effectEstimate.extension:precisionEstimate.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`precisionEstimate`
470. Extension.extension:effectEstimate.extension:precisionEstimate.value[x]
Definition	Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Value of extension
Control	0..1
Type	Choice of: base64Binary, boolean, canonical, code, date, dateTime, decimal, id, instant, integer, markdown, oid, positiveInt, string, time, unsignedInt, uri, url, uuid, Address, Age, Annotation, Attachment, CodeableConcept, CodeableReference, Coding, ContactPoint, Count, Distance, Duration, HumanName, Identifier, Money, Period, Quantity, Range, Ratio, RatioRange, Reference, SampledData, Signature, Timing, ContactDetail, Contributor, DataRequirement, Expression, ParameterDefinition, RelatedArtifact, TriggerDefinition, UsageContext, Dosage
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
472. Extension.extension:effectEstimate.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`effectEstimate`
474. Extension.extension:effectEstimate.value[x]
Definition	Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Value of extension
Control	0..1
Type	Choice of: base64Binary, boolean, canonical, code, date, dateTime, decimal, id, instant, integer, markdown, oid, positiveInt, string, time, unsignedInt, uri, url, uuid, Address, Age, Annotation, Attachment, CodeableConcept, CodeableReference, Coding, ContactPoint, Count, Distance, Duration, HumanName, Identifier, Money, Period, Quantity, Range, Ratio, RatioRange, Reference, SampledData, Signature, Timing, ContactDetail, Contributor, DataRequirement, Expression, ParameterDefinition, RelatedArtifact, TriggerDefinition, UsageContext, Dosage
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
476. Extension.extension:certainty
Slice Name	certainty
Definition	A description of the certainty of the effect estimate.
Short	How certain is the effect
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
478. Extension.extension:certainty.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
480. Extension.extension:certainty.extension
Definition	An Extension
Short	Extension
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension`. The slices areUnordered and Closed, and can be differentiated using the following discriminators: value @ url
482. Extension.extension:certainty.extension:rating
Slice Name	rating
Definition	A rating of the certainty of the effect estimate.
Short	Certainty rating
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
484. Extension.extension:certainty.extension:rating.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
486. Extension.extension:certainty.extension:rating.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
488. Extension.extension:certainty.extension:rating.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`rating`
490. Extension.extension:certainty.extension:rating.value[x]
Definition	A rating of the certainty of the effect estimate.
Short	Certainty rating
Control	0..1
Binding	Unless not suitable, these codes SHALL be taken from R4_evidence_quality_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-evidence-quality-for-R4B\|0.0.1-snapshot-2`) The quality of the evidence described. The code system used specifies the quality scale used to grade this evidence source while the code specifies the actual quality score (represented as a coded value) associated with the evidence.
Type	CodeableConcept
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
492. Extension.extension:certainty.extension:note
Slice Name	note
Definition	A human-readable string to clarify or explain concepts about the resource.
Short	Used for footnotes or explanatory notes
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
494. Extension.extension:certainty.extension:note.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
496. Extension.extension:certainty.extension:note.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
498. Extension.extension:certainty.extension:note.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`note`
500. Extension.extension:certainty.extension:note.value[x]
Definition	A human-readable string to clarify or explain concepts about the resource.
Short	Used for footnotes or explanatory notes
Control	0..1
Type	Annotation
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
502. Extension.extension:certainty.extension:certaintySubcomponent
Slice Name	certaintySubcomponent
Definition	A description of a component of the overall certainty.
Short	A component that contributes to the overall certainty
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
504. Extension.extension:certainty.extension:certaintySubcomponent.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
506. Extension.extension:certainty.extension:certaintySubcomponent.extension
Definition	An Extension
Short	Extension
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension`. The slices areUnordered and Closed, and can be differentiated using the following discriminators: value @ url
508. Extension.extension:certainty.extension:certaintySubcomponent.extension:type
Slice Name	type
Definition	This cross-version extension represents EffectEvidenceSynthesis.certainty.certaintySubcomponent.type from http://hl7.org/fhir/StructureDefinition/EffectEvidenceSynthesis\|4.0.1 for use in FHIR R4B.
Short	Type of subcomponent of certainty rating
Control	0..1
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
510. Extension.extension:certainty.extension:certaintySubcomponent.extension:type.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
512. Extension.extension:certainty.extension:certaintySubcomponent.extension:type.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
514. Extension.extension:certainty.extension:certaintySubcomponent.extension:type.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`type`
516. Extension.extension:certainty.extension:certaintySubcomponent.extension:type.value[x]
Definition	This cross-version extension represents EffectEvidenceSynthesis.certainty.certaintySubcomponent.type from http://hl7.org/fhir/StructureDefinition/EffectEvidenceSynthesis\|4.0.1 for use in FHIR R4B.
Short	Type of subcomponent of certainty rating
Control	0..1
Binding	Unless not suitable, these codes SHALL be taken from R4_certainty_subcomponent_type_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-certainty-subcomponent-type-for-R4B\|0.0.1-snapshot-2`) The subcomponent classification of quality of evidence rating systems.
Type	CodeableConcept
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
518. Extension.extension:certainty.extension:certaintySubcomponent.extension:rating
Slice Name	rating
Definition	A rating of a subcomponent of rating certainty.
Short	Subcomponent certainty rating
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
520. Extension.extension:certainty.extension:certaintySubcomponent.extension:rating.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
522. Extension.extension:certainty.extension:certaintySubcomponent.extension:rating.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
524. Extension.extension:certainty.extension:certaintySubcomponent.extension:rating.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`rating`
526. Extension.extension:certainty.extension:certaintySubcomponent.extension:rating.value[x]
Definition	A rating of a subcomponent of rating certainty.
Short	Subcomponent certainty rating
Control	0..1
Binding	Unless not suitable, these codes SHALL be taken from R4_certainty_subcomponent_rating_for_R4B (0.0.1-snapshot-2) (extensible to `http://hl7.org/fhir/4.0/ValueSet/R4-certainty-subcomponent-rating-for-R4B\|0.0.1-snapshot-2`) The quality rating of the subcomponent of a quality of evidence rating.
Type	CodeableConcept
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
528. Extension.extension:certainty.extension:certaintySubcomponent.extension:note
Slice Name	note
Definition	A human-readable string to clarify or explain concepts about the resource.
Short	Used for footnotes or explanatory notes
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
530. Extension.extension:certainty.extension:certaintySubcomponent.extension:note.id
Definition	Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
Short	Unique id for inter-element referencing
Control	0..1
Type	id
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
532. Extension.extension:certainty.extension:certaintySubcomponent.extension:note.extension
Definition	May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
Short	Additional content defined by implementations
Comments	There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
Control	0..*
Type	Extension
Is Modifier	false
Summary	false
Alternate Names	extensions, user content
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`) ext-1: Must have either extensions or value[x], not both (`extension.exists() != value.exists()`)
Slicing	This element introduces a set of slices on `Extension.extension.extension.extension.extension`. The slices areUnordered and Open, and can be differentiated using the following discriminators: value @ url
534. Extension.extension:certainty.extension:certaintySubcomponent.extension:note.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`note`
536. Extension.extension:certainty.extension:certaintySubcomponent.extension:note.value[x]
Definition	A human-readable string to clarify or explain concepts about the resource.
Short	Used for footnotes or explanatory notes
Control	0..1
Type	Annotation
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
538. Extension.extension:certainty.extension:certaintySubcomponent.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`certaintySubcomponent`
540. Extension.extension:certainty.extension:certaintySubcomponent.value[x]
Definition	Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Value of extension
Control	0..1
Type	Choice of: base64Binary, boolean, canonical, code, date, dateTime, decimal, id, instant, integer, markdown, oid, positiveInt, string, time, unsignedInt, uri, url, uuid, Address, Age, Annotation, Attachment, CodeableConcept, CodeableReference, Coding, ContactPoint, Count, Distance, Duration, HumanName, Identifier, Money, Period, Quantity, Range, Ratio, RatioRange, Reference, SampledData, Signature, Timing, ContactDetail, Contributor, DataRequirement, Expression, ParameterDefinition, RelatedArtifact, TriggerDefinition, UsageContext, Dosage
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
542. Extension.extension:certainty.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`certainty`
544. Extension.extension:certainty.value[x]
Definition	Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Value of extension
Control	0..1
Type	Choice of: base64Binary, boolean, canonical, code, date, dateTime, decimal, id, instant, integer, markdown, oid, positiveInt, string, time, unsignedInt, uri, url, uuid, Address, Age, Annotation, Attachment, CodeableConcept, CodeableReference, Coding, ContactPoint, Count, Distance, Duration, HumanName, Identifier, Money, Period, Quantity, Range, Ratio, RatioRange, Reference, SampledData, Signature, Timing, ContactDetail, Contributor, DataRequirement, Expression, ParameterDefinition, RelatedArtifact, TriggerDefinition, UsageContext, Dosage
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)
546. Extension.url
Definition	Source of the definition for the extension code - a logical name or a URL.
Short	identifies the meaning of the extension
Comments	The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.
Control	1..1
Type	uri
Is Modifier	false
XML Format	In the XML format, this property is represented as an attribute.
Summary	false
Fixed Value	`http://hl7.org/fhir/4.0/StructureDefinition/extension-EffectEvidenceSynthesis`
548. Extension.value[x]
Definition	Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).
Short	Value of extension
Control	0..1
Type	Choice of: base64Binary, boolean, canonical, code, date, dateTime, decimal, id, instant, integer, markdown, oid, positiveInt, string, time, unsignedInt, uri, url, uuid, Address, Age, Annotation, Attachment, CodeableConcept, CodeableReference, Coding, ContactPoint, Count, Distance, Duration, HumanName, Identifier, Money, Period, Quantity, Range, Ratio, RatioRange, Reference, SampledData, Signature, Timing, ContactDetail, Contributor, DataRequirement, Expression, ParameterDefinition, RelatedArtifact, TriggerDefinition, UsageContext, Dosage
[x] Note	SeeChoice of Data Typesfor further information about how to use [x]
Is Modifier	false
Primitive Value	This primitive element may be present, or absent, or replaced by an extension
Summary	false
Invariants	ele-1: All FHIR elements must have a @value or children (`hasValue() or (children().count() > id.count())`)