@prefix fhir: <http://hl7.org/fhir/> .
@prefix loinc: <https://loinc.org/rdf/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix sct: <http://snomed.info/id/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://hl7.org/fhir/uv/order-catalog/MedicationKnowledge/example-drug-clarithromycin-25mg-granule-suspension> a fhir:MedicationKnowledge ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "example-drug-clarithromycin-25mg-granule-suspension"] ; # 
  fhir:meta [
     fhir:profile ( [
       fhir:v "http://hl7.org/fhir/uv/order-catalog/StructureDefinition/DrugKnowledge"^^xsd:anyURI ;
       fhir:l <http://hl7.org/fhir/uv/order-catalog/StructureDefinition/DrugKnowledge>
     ] )
  ] ; # 
  fhir:language [ fhir:v "en-US"] ; # 
  fhir:text [
     fhir:status [ fhir:v "extensions" ] ;
     fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\" xml:lang=\"en-US\" lang=\"en-US\"><p class=\"res-header-id\"><b>Generated Narrative: MedicationKnowledge example-drug-clarithromycin-25mg-granule-suspension</b></p><a name=\"example-drug-clarithromycin-25mg-granule-suspension\"> </a><a name=\"hcexample-drug-clarithromycin-25mg-granule-suspension\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Language: en-US</p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-DrugKnowledge.html\">item in a catalog of drugs</a></p></div><p><b>Reference to a catalog</b>: <a href=\"Composition-example-medication-catalog-header.html\">Composition Drugs authorized for prescription in Healthyland</a></p><p><b>code</b>: <span title=\"Codes:{http://snomed.info/sct 769316002}\">Clarithromycin 25 mg/mL oral suspension</span></p><p><b>intendedJurisdiction</b>: <span title=\"Codes:\">Healthyland</span></p><p><b>name</b>: CLARITHROMYCINE GENERIC-LAB 25 mg/ml, granules for oral suspension</p><p><b>productType</b>: <span title=\"Codes:\">Generic product</span></p><blockquote><p><b>indicationGuideline</b></p><h3>Indications</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"ClinicalUseDefinition-example-bacterial-pharyngitis-indication.html\">ClinicalUseDefinition: type = indication</a></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"ClinicalUseDefinition-example-acute-otitis-media-indication.html\">ClinicalUseDefinition: type = indication</a></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"ClinicalUseDefinition-example-bacterial-sinusitis-indication.html\">ClinicalUseDefinition: type = indication</a></td></tr></table><blockquote><p><b>dosingGuideline</b></p><h3>PatientCharacteristics</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://loinc.org 30525-0}\">Age</span></td><td>0.5-12 years</td></tr></table></blockquote></blockquote><blockquote><p><b>medicineClassification</b></p><p><b>type</b>: <span title=\"Codes:\">Anatomical Therapeutic Chemical (ATC)</span></p><p><b>source</b>: <a href=\"https://www.whocc.no/atc/structure_and_principles/\">https://www.whocc.no/atc/structure_and_principles/</a></p><p><b>classification</b>: <span title=\"Codes:{http://www.whocc.no/atc J01FA09}\">Clarithromycin</span></p></blockquote><blockquote><p><b>medicineClassification</b></p><p><b>type</b>: <span title=\"Codes:\">SNOMED CT drug dispositions</span></p><p><b>source</b>: <a href=\"https://confluence.ihtsdotools.org/display/DOCEG/SNOMED+CT+Editorial+Guide+-+Pharmaceutical+and+Biologic+Product\">https://confluence.ihtsdotools.org/display/DOCEG/SNOMED+CT+Editorial+Guide+-+Pharmaceutical+and+Biologic+Product</a></p><p><b>classification</b>: <span title=\"Codes:{http://snomed.info/sct 419241000}\">Substance with antibacterial mechanism of action (substance)</span></p></blockquote><blockquote><p><b>packaging</b></p><h3>Costs</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>EffectiveDate</b></td><td><b>Type</b></td><td><b>Source</b></td><td><b>Cost[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>2021-02-01 --&gt; (ongoing)</td><td><span title=\"Codes:\">public price</span></td><td>Healthyland Drug Administration</td><td><span title=\"Euro\">€5.18</span> (EUR)</td></tr><tr><td style=\"display: none\">*</td><td>2020-09-30 --&gt; 2021-01-31</td><td><span title=\"Codes:\">public price</span></td><td>Healthyland Drug Administration</td><td><span title=\"Euro\">€5.20</span> (EUR)</td></tr><tr><td style=\"display: none\">*</td><td>2010-03-01 --&gt; (ongoing)</td><td><span title=\"Codes:\">manufacturers' cost</span></td><td>Healthyland Drug Administration</td><td><span title=\"Euro\">€4.40</span> (EUR)</td></tr></table><p><b>packagedProduct</b>: <a href=\"PackagedProductDefinition-example-drug-package-clarithromycin.html\">PackagedProductDefinition Package for CLARITHROMYCINE GENERIC-LAB 25 mg/ml, granules for oral suspension in 100 ml HDPE bottle</a></p></blockquote><p><b>clinicalUseIssue</b>: <a href=\"ClinicalUseDefinition-example-allergy-contraindication.html\">ClinicalUseDefinition: type = contraindication</a></p><blockquote><p><b>definitional</b></p><p><b>doseForm</b>: <span title=\"Codes:{http://snomed.info/sct 385029002}, {http://standardterms.edqm.eu 10113000}\">Granules for oral suspension</span></p><p><b>intendedRoute</b>: <span title=\"Codes:{http://snomed.info/sct 26643006}\">Oral route</span></p><blockquote><p><b>ingredient</b></p><h3>Items</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Concept</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 387487009}\">Clarithromycin</span></td></tr></table><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v3-RoleClass ACTIB}\">active ingredient - basis of strength</span></p><p><b>strength</b>: 25 milligram<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  codemg = 'mg')</span>/1 milliliter<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  codemL = 'mL')</span></p></blockquote><blockquote><p><b>ingredient</b></p><h3>Items</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Concept</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 11320009}\">Sucrose</span></td></tr></table><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v3-RoleClass IACT}\">inactive ingredient</span></p></blockquote></blockquote></div>"^^rdf:XMLLiteral ]
  ] ; # 
  fhir:extension ( [
     fhir:url [
       fhir:v "http://hl7.org/fhir/uv/order-catalog/StructureDefinition/CatalogReference"^^xsd:anyURI ;
       fhir:l <http://hl7.org/fhir/uv/order-catalog/StructureDefinition/CatalogReference>
     ] ;
     fhir:value [
       a fhir:Reference ;
       fhir:l <http://hl7.org/fhir/uv/order-catalog/Composition/example-medication-catalog-header> ;
       fhir:reference [ fhir:v "Composition/example-medication-catalog-header" ]
     ]
  ] ) ; # 
  fhir:code [
     fhir:coding ( [
       a sct:769316002 ;
       fhir:system [
         fhir:v "http://snomed.info/sct"^^xsd:anyURI ;
         fhir:l <http://snomed.info/sct>
       ] ;
       fhir:code [ fhir:v "769316002" ] ;
       fhir:display [ fhir:v "Clarithromycin 25 mg/mL oral suspension" ]
     ] )
  ] ; # 
  fhir:intendedJurisdiction ( [
     fhir:text [ fhir:v "Healthyland" ]
  ] ) ; # 
  fhir:name ( [ fhir:v "CLARITHROMYCINE GENERIC-LAB 25 mg/ml, granules for oral suspension"] ) ; # 
  fhir:productType ( [
     fhir:text [ fhir:v "Generic product" ]
  ] ) ; # 
  fhir:indicationGuideline ( [
     fhir:indication ( [
       fhir:reference [
         fhir:l <http://hl7.org/fhir/uv/order-catalog/ClinicalUseDefinition/example-bacterial-pharyngitis-indication> ;
         fhir:reference [ fhir:v "ClinicalUseDefinition/example-bacterial-pharyngitis-indication" ]
       ]
     ] [
       fhir:reference [
         fhir:l <http://hl7.org/fhir/uv/order-catalog/ClinicalUseDefinition/example-acute-otitis-media-indication> ;
         fhir:reference [ fhir:v "ClinicalUseDefinition/example-acute-otitis-media-indication" ]
       ]
     ] [
       fhir:reference [
         fhir:l <http://hl7.org/fhir/uv/order-catalog/ClinicalUseDefinition/example-bacterial-sinusitis-indication> ;
         fhir:reference [ fhir:v "ClinicalUseDefinition/example-bacterial-sinusitis-indication" ]
       ]
     ] ) ;
     fhir:dosingGuideline ( [
       fhir:patientCharacteristic ( [
         fhir:type [
           fhir:coding ( [
             a loinc:30525-0 ;
             fhir:system [
               fhir:v "http://loinc.org"^^xsd:anyURI ;
               fhir:l <http://loinc.org>
             ] ;
             fhir:code [ fhir:v "30525-0" ] ;
             fhir:display [ fhir:v "Age" ]
           ] )
         ] ;
         fhir:value [
           a fhir:Range ;
           fhir:low [
             fhir:value [ fhir:v 0.5 ] ;
             fhir:unit [ fhir:v "years" ] ;
             fhir:system [
               fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ;
               fhir:l <http://unitsofmeasure.org>
             ] ;
             fhir:code [ fhir:v "a" ]
           ] ;
           fhir:high [
             fhir:value [ fhir:v "12"^^xsd:decimal ] ;
             fhir:unit [ fhir:v "years" ] ;
             fhir:system [
               fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ;
               fhir:l <http://unitsofmeasure.org>
             ] ;
             fhir:code [ fhir:v "a" ]
           ]
         ]
       ] )
     ] )
  ] ) ; # 
  fhir:medicineClassification ( [
     fhir:type [
       fhir:text [ fhir:v "Anatomical Therapeutic Chemical (ATC)" ]
     ] ;
     fhir:source [
       a fhir:Uri ;
       fhir:v "https://www.whocc.no/atc/structure_and_principles/"^^xsd:anyURI ;
       fhir:l <https://www.whocc.no/atc/structure_and_principles/>
     ] ;
     fhir:classification ( [
       fhir:coding ( [
         fhir:system [
           fhir:v "http://www.whocc.no/atc"^^xsd:anyURI ;
           fhir:l <http://www.whocc.no/atc>
         ] ;
         fhir:code [ fhir:v "J01FA09" ] ;
         fhir:display [ fhir:v "Clarithromycin" ]
       ] )
     ] )
  ] [
     fhir:type [
       fhir:text [ fhir:v "SNOMED CT drug dispositions" ]
     ] ;
     fhir:source [
       a fhir:Uri ;
       fhir:v "https://confluence.ihtsdotools.org/display/DOCEG/SNOMED+CT+Editorial+Guide+-+Pharmaceutical+and+Biologic+Product"^^xsd:anyURI ;
       fhir:l <https://confluence.ihtsdotools.org/display/DOCEG/SNOMED+CT+Editorial+Guide+-+Pharmaceutical+and+Biologic+Product>
     ] ;
     fhir:classification ( [
       fhir:coding ( [
         a sct:419241000 ;
         fhir:system [
           fhir:v "http://snomed.info/sct"^^xsd:anyURI ;
           fhir:l <http://snomed.info/sct>
         ] ;
         fhir:code [ fhir:v "419241000" ] ;
         fhir:display [ fhir:v "Substance with antibacterial mechanism of action (substance)" ]
       ] )
     ] )
  ] ) ; # 
  fhir:packaging ( [
     fhir:cost ( [
       fhir:effectiveDate ( [
         fhir:start [ fhir:v "2021-02-01"^^xsd:date ]
       ] ) ;
       fhir:type [
         fhir:text [ fhir:v "public price" ]
       ] ;
       fhir:source [ fhir:v "Healthyland Drug Administration" ] ;
       fhir:cost [
         a fhir:Money ;
         fhir:value [ fhir:v 5.18 ] ;
         fhir:currency [ fhir:v "EUR" ]
       ]
     ] [
       fhir:effectiveDate ( [
         fhir:start [ fhir:v "2020-09-30"^^xsd:date ] ;
         fhir:end [ fhir:v "2021-01-31"^^xsd:date ]
       ] ) ;
       fhir:type [
         fhir:text [ fhir:v "public price" ]
       ] ;
       fhir:source [ fhir:v "Healthyland Drug Administration" ] ;
       fhir:cost [
         a fhir:Money ;
         fhir:value [ fhir:v 5.2 ] ;
         fhir:currency [ fhir:v "EUR" ]
       ]
     ] [
       fhir:effectiveDate ( [
         fhir:start [ fhir:v "2010-03-01"^^xsd:date ]
       ] ) ;
       fhir:type [
         fhir:text [ fhir:v "manufacturers' cost" ]
       ] ;
       fhir:source [ fhir:v "Healthyland Drug Administration" ] ;
       fhir:cost [
         a fhir:Money ;
         fhir:value [ fhir:v 4.4 ] ;
         fhir:currency [ fhir:v "EUR" ]
       ]
     ] ) ;
     fhir:packagedProduct [
       fhir:l <http://hl7.org/fhir/uv/order-catalog/PackagedProductDefinition/example-drug-package-clarithromycin> ;
       fhir:reference [ fhir:v "PackagedProductDefinition/example-drug-package-clarithromycin" ]
     ]
  ] ) ; # 
  fhir:clinicalUseIssue ( [
     fhir:l <http://hl7.org/fhir/uv/order-catalog/ClinicalUseDefinition/example-allergy-contraindication> ;
     fhir:reference [ fhir:v "ClinicalUseDefinition/example-allergy-contraindication" ]
  ] ) ; # 
  fhir:definitional [
     fhir:doseForm [
       fhir:coding ( [
         a sct:385029002 ;
         fhir:system [
           fhir:v "http://snomed.info/sct"^^xsd:anyURI ;
           fhir:l <http://snomed.info/sct>
         ] ;
         fhir:code [ fhir:v "385029002" ] ;
         fhir:display [ fhir:v "Granules for oral suspension" ]
       ] [
         fhir:system [
           fhir:v "http://standardterms.edqm.eu"^^xsd:anyURI ;
           fhir:l <http://standardterms.edqm.eu>
         ] ;
         fhir:code [ fhir:v "10113000" ] ;
         fhir:display [ fhir:v "Granules for oral suspension" ]
       ] )
     ] ;
     fhir:intendedRoute ( [
       fhir:coding ( [
         a sct:26643006 ;
         fhir:system [
           fhir:v "http://snomed.info/sct"^^xsd:anyURI ;
           fhir:l <http://snomed.info/sct>
         ] ;
         fhir:code [ fhir:v "26643006" ] ;
         fhir:display [ fhir:v "Oral route" ]
       ] )
     ] ) ;
     fhir:ingredient ( [
       fhir:item [
         fhir:concept [
           fhir:coding ( [
             a sct:387487009 ;
             fhir:system [
               fhir:v "http://snomed.info/sct"^^xsd:anyURI ;
               fhir:l <http://snomed.info/sct>
             ] ;
             fhir:code [ fhir:v "387487009" ] ;
             fhir:display [ fhir:v "Clarithromycin" ]
           ] )
         ]
       ] ;
       fhir:type [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/v3-RoleClass"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/v3-RoleClass>
           ] ;
           fhir:code [ fhir:v "ACTIB" ] ;
           fhir:display [ fhir:v "active ingredient - basis of strength" ]
         ] )
       ] ;
       fhir:strength [
         a fhir:Ratio ;
         fhir:numerator [
           fhir:value [ fhir:v "25"^^xsd:decimal ] ;
           fhir:unit [ fhir:v "milligram" ] ;
           fhir:system [
             fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ;
             fhir:l <http://unitsofmeasure.org>
           ] ;
           fhir:code [ fhir:v "mg" ]
         ] ;
         fhir:denominator [
           fhir:value [ fhir:v "1"^^xsd:decimal ] ;
           fhir:unit [ fhir:v "milliliter" ] ;
           fhir:system [
             fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ;
             fhir:l <http://unitsofmeasure.org>
           ] ;
           fhir:code [ fhir:v "mL" ]
         ]
       ]
     ] [
       fhir:item [
         fhir:concept [
           fhir:coding ( [
             a sct:11320009 ;
             fhir:system [
               fhir:v "http://snomed.info/sct"^^xsd:anyURI ;
               fhir:l <http://snomed.info/sct>
             ] ;
             fhir:code [ fhir:v "11320009" ] ;
             fhir:display [ fhir:v "Sucrose" ]
           ] )
         ]
       ] ;
       fhir:type [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/v3-RoleClass"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/v3-RoleClass>
           ] ;
           fhir:code [ fhir:v "IACT" ] ;
           fhir:display [ fhir:v "inactive ingredient" ]
         ] )
       ]
     ] )
  ] . # 

<http://hl7.org/fhir/uv/order-catalog/Composition/example-medication-catalog-header> a fhir:Uv .

<http://hl7.org/fhir/uv/order-catalog/ClinicalUseDefinition/example-bacterial-pharyngitis-indication> a fhir:Uv .

<http://hl7.org/fhir/uv/order-catalog/ClinicalUseDefinition/example-acute-otitis-media-indication> a fhir:Uv .

<http://hl7.org/fhir/uv/order-catalog/ClinicalUseDefinition/example-bacterial-sinusitis-indication> a fhir:Uv .

<http://hl7.org/fhir/uv/order-catalog/PackagedProductDefinition/example-drug-package-clarithromycin> a fhir:Uv .

<http://hl7.org/fhir/uv/order-catalog/ClinicalUseDefinition/example-allergy-contraindication> a fhir:Uv .

# -------------------------------------------------------------------------------------

