{
  "resourceType" : "ClinicalUseDefinition",
  "id" : "example-interaction",
  "meta" : {
    "profile" : ["http://hl7.org/fhir/uv/order-catalog/StructureDefinition/InteractionDefinition"]
  },
  "language" : "en-US",
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\" xml:lang=\"en-US\" lang=\"en-US\">\n            <p>Drug interaction: Clarithromycin and Warfarin - increased anticoagulant effect</p>\n        </div>"
  },
  "type" : "interaction",
  "interaction" : {
    "interactant" : [{
      "itemCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "387487009",
          "display" : "Clarithromycin"
        }]
      }
    },
    {
      "itemCodeableConcept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "372756006",
          "display" : "Warfarin"
        }]
      }
    }],
    "type" : {
      "coding" : [{
        "system" : "http://hl7.org/fhir/interaction-type",
        "code" : "drug-drug",
        "display" : "drug to drug interaction"
      }]
    },
    "effect" : {
      "concept" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "419511003",
          "display" : "Propensity to adverse reactions to drug"
        }],
        "text" : "Increased anticoagulant effect and risk of bleeding"
      }
    }
  }
}