Genomics Reporting Implementation Guide
3.0.0 - STU3
Genomics Reporting Implementation Guide
3.0.0 - STU3
This page is part of the Genetic Reporting Implementation Guide (v3.0.0: STU3) based on FHIR (HL7® FHIR® Standard) R4. This is the current published version. For a full list of available versions, see the Directory of published versions
@prefix fhir: <http://hl7.org/fhir/> . @prefix loinc: <https://loinc.org/rdf/> . @prefix owl: <http://www.w3.org/2002/07/owl#> . @prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> . @prefix xsd: <http://www.w3.org/2001/XMLSchema#> . # - resource ------------------------------------------------------------------- a fhir:Bundle ; fhir:nodeRole fhir:treeRoot ; fhir:id [ fhir:v "bundle-oncologyexamples-r4-withGrouping"] ; # fhir:type [ fhir:v "transaction"] ; # fhir:entry ( [ fhir:fullUrl [ fhir:v "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d"^^xsd:anyURI ] ; ( fhir:resource <urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d> ) ; fhir:request [ fhir:method [ fhir:v "POST" ] ; fhir:url [ fhir:v "Patient"^^xsd:anyURI ] ] ] [ fhir:fullUrl [ fhir:v "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef"^^xsd:anyURI ] ; ( fhir:resource <urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef> ) ; fhir:request [ fhir:method [ fhir:v "POST" ] ; fhir:url [ fhir:v "Practitioner"^^xsd:anyURI ] ] ] [ fhir:fullUrl [ fhir:v "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d"^^xsd:anyURI ] ; ( fhir:resource <urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d> ) ; fhir:request [ fhir:method [ fhir:v "POST" ] ; fhir:url [ fhir:v "Specimen"^^xsd:anyURI ] ] ] [ fhir:fullUrl [ fhir:v "urn:uuid:40e85eda-4d31-4bd2-a5a0-c39d63f9824f"^^xsd:anyURI ] ; ( fhir:resource <urn:uuid:40e85eda-4d31-4bd2-a5a0-c39d63f9824f> ) ; fhir:request [ fhir:method [ fhir:v "POST" ] ; fhir:url [ fhir:v "Observation"^^xsd:anyURI ] ] ] [ fhir:fullUrl [ fhir:v "urn:uuid:64b91716-6431-41bd-8fd4-7ac99bebdee9"^^xsd:anyURI ] ; ( fhir:resource <urn:uuid:64b91716-6431-41bd-8fd4-7ac99bebdee9> ) ; fhir:request [ fhir:method [ fhir:v "POST" ] ; fhir:url [ fhir:v "Observation"^^xsd:anyURI ] ] ] [ fhir:fullUrl [ fhir:v "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12d"^^xsd:anyURI ] ; ( fhir:resource <urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12d> ) ; fhir:request [ fhir:method [ fhir:v "POST" ] ; fhir:url [ fhir:v "Observation"^^xsd:anyURI ] ] ] [ fhir:fullUrl [ fhir:v "urn:uuid:772de7d7-e1bd-4183-bdb5-cea8eda317cd"^^xsd:anyURI ] ; ( fhir:resource <urn:uuid:772de7d7-e1bd-4183-bdb5-cea8eda317cd> ) ; fhir:request [ fhir:method [ fhir:v "POST" ] ; fhir:url [ fhir:v "Observation"^^xsd:anyURI ] ] ] [ fhir:fullUrl [ fhir:v "urn:uuid:b33eb7ec-d83e-49d2-b0f3-729d024ebe01"^^xsd:anyURI ] ; ( fhir:resource <urn:uuid:b33eb7ec-d83e-49d2-b0f3-729d024ebe01> ) ; fhir:request [ fhir:method [ fhir:v "POST" ] ; fhir:url [ fhir:v "Observation"^^xsd:anyURI ] ] ] [ fhir:fullUrl [ fhir:v "urn:uuid:1bf9642d-fd1c-4819-8c5d-44fae4bad524"^^xsd:anyURI ] ; ( fhir:resource <urn:uuid:1bf9642d-fd1c-4819-8c5d-44fae4bad524> ) ; fhir:request [ fhir:method [ fhir:v "POST" ] ; fhir:url [ fhir:v "Observation"^^xsd:anyURI ] ] ] [ fhir:fullUrl [ fhir:v "urn:uuid:1301943b-55db-4adf-8355-3635f7268a1b"^^xsd:anyURI ] ; ( fhir:resource <urn:uuid:1301943b-55db-4adf-8355-3635f7268a1b> ) ; fhir:request [ fhir:method [ fhir:v "POST" ] ; fhir:url [ fhir:v "Observation"^^xsd:anyURI ] ] ] [ fhir:fullUrl [ fhir:v "urn:uuid:05713d1c-0df5-46d5-a5a9-2085eef56c20"^^xsd:anyURI ] ; ( fhir:resource <urn:uuid:05713d1c-0df5-46d5-a5a9-2085eef56c20> ) ; fhir:request [ fhir:method [ fhir:v "POST" ] ; fhir:url [ fhir:v "Observation"^^xsd:anyURI ] ] ] [ fhir:fullUrl [ fhir:v "urn:uuid:294f1401-e2eb-4df1-b6d2-09e1b7a6eca4"^^xsd:anyURI ] ; ( fhir:resource <urn:uuid:294f1401-e2eb-4df1-b6d2-09e1b7a6eca4> ) ; fhir:request [ fhir:method [ fhir:v "POST" ] ; fhir:url [ fhir:v "Observation"^^xsd:anyURI ] ] ] [ fhir:fullUrl [ fhir:v "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12f"^^xsd:anyURI ] ; ( fhir:resource <urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12f> ) ; fhir:request [ fhir:method [ fhir:v "POST" ] ; fhir:url [ fhir:v "Observation"^^xsd:anyURI ] ] ] [ fhir:fullUrl [ fhir:v "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12e"^^xsd:anyURI ] ; ( fhir:resource <urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12e> ) ; fhir:request [ fhir:method [ fhir:v "POST" ] ; fhir:url [ fhir:v "Observation"^^xsd:anyURI ] ] ] [ fhir:fullUrl [ fhir:v "urn:uuid:ad7a499b-a43b-4cc8-bf46-cac62d9ecae5"^^xsd:anyURI ] ; ( fhir:resource <urn:uuid:ad7a499b-a43b-4cc8-bf46-cac62d9ecae5> ) ; fhir:request [ fhir:method [ fhir:v "POST" ] ; fhir:url [ fhir:v "DiagnosticReport"^^xsd:anyURI ] ] ] ) . # <urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d> a fhir:Patient ; fhir:id [ fhir:v "Inline-Instance-for-oncologyexamples-r4-withGrouping-1"] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Patient_Inline-Instance-for-oncologyexamples-r4-withGrouping-1\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Patient Inline-Instance-for-oncologyexamples-r4-withGrouping-1</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-1\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-1\"> </a><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-1-en-US\"> </a><p style=\"border: 1px #661aff solid; background-color: #e6e6ff; padding: 10px;\">Carrot John Mr Male, DoB: 1962-12-31 ( 1007)</p><hr/><table class=\"grid\"><tr><td style=\"background-color: #f3f5da\" title=\"Patient Links\">Links:</td><td colspan=\"3\"><ul><li>General Practitioner: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Bundle: type = transaction</a></li></ul></td></tr></table></div>" ] ; # fhir:identifier ( [ fhir:value [ fhir:v "1007" ] ] ) ; # fhir:name ( [ ( fhir:given [ fhir:v "Carrot" ] [ fhir:v "John" ] [ fhir:v "Mr" ] ) ] ) ; # fhir:gender [ fhir:v "male"] ; # fhir:birthDate [ fhir:v "1962-12-31"^^xsd:date] ; # fhir:generalPractitioner ( [ fhir:reference [ fhir:v "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ) . # <urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef> a fhir:Practitioner ; fhir:id [ fhir:v "Inline-Instance-for-oncologyexamples-r4-withGrouping-2"] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Practitioner_Inline-Instance-for-oncologyexamples-r4-withGrouping-2\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Practitioner Inline-Instance-for-oncologyexamples-r4-withGrouping-2</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-2\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-2\"> </a><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-2-en-US\"> </a><p><b>identifier</b>: 4654765876</p><p><b>name</b>: Akerman Philip Prof </p><p><b>address</b>: Castro Valley CA </p></div>" ] ; # fhir:identifier ( [ fhir:value [ fhir:v "4654765876" ] ] ) ; # fhir:name ( [ ( fhir:given [ fhir:v "Akerman" ] [ fhir:v "Philip" ] [ fhir:v "Prof" ] ) ] ) ; # fhir:address ( [ fhir:city [ fhir:v "Castro Valley" ] ; fhir:state [ fhir:v "CA" ] ] ) . # <urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d> a fhir:Specimen ; fhir:id [ fhir:v "Inline-Instance-for-oncologyexamples-r4-withGrouping-3"] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Specimen_Inline-Instance-for-oncologyexamples-r4-withGrouping-3\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Specimen Inline-Instance-for-oncologyexamples-r4-withGrouping-3</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-3\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-3\"> </a><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-3-en-US\"> </a><p><b>identifier</b>: 076e1948-2217-11e9-94d8-12e241dc1f66</p><p><b>status</b>: Available</p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Bundle: type = transaction</a></p><h3>Collections</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Collector</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Bundle: type = transaction</a></td></tr></table></div>" ] ; # fhir:identifier ( [ fhir:value [ fhir:v "076e1948-2217-11e9-94d8-12e241dc1f66" ] ] ) ; # fhir:status [ fhir:v "available"] ; # fhir:subject [ fhir:reference [ fhir:v "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ] ; # fhir:collection [ fhir:collector [ fhir:reference [ fhir:v "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ] . # <urn:uuid:40e85eda-4d31-4bd2-a5a0-c39d63f9824f> a fhir:Observation ; fhir:id [ fhir:v "Inline-Instance-for-oncologyexamples-r4-withGrouping-4"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-biomarker"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-biomarker> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-oncologyexamples-r4-withGrouping-4\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-withGrouping-4</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-4\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-4\"> </a><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-4-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs biomarker-category}\">A characterization of a given biomarker observation.</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 94076-7}\">Mutations/Megabase [# Ratio] in Tumor</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Bundle: type = transaction</a></p><p><b>effective</b>: 2023-05-01</p><p><b>performer</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Bundle: type = transaction</a></p><p><b>value</b>: 25 somatic variants per megabase of sequenced DNA<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code1/1000000 = '1/1000000')</span></p><p><b>specimen</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a5d6a6a9-4859-480e-85b2-56974fef3b9d\">Bundle: type = transaction</a></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs biomarker-category}\">A characterization of a given biomarker observation.</span></td><td><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/molecular-biomarker-ontology-cs molgen}\">molecular sequence adjacent category</span></td></tr></table></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "biomarker-category" ] ] ) ] [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0074"^^xsd:anyURI ] ; fhir:code [ fhir:v "GE" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:94076-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "94076-7" ] ; fhir:display [ fhir:v "Mutations/Megabase [# Ratio] in Tumor" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ] ; # fhir:effective [ fhir:v "2023-05-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ) ; # fhir:value [ a fhir:Quantity ; fhir:value [ fhir:v "25"^^xsd:decimal ] ; fhir:unit [ fhir:v "somatic variants per megabase of sequenced DNA" ] ; fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "1/1000000" ] ] ; # fhir:specimen [ fhir:reference [ fhir:v "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d" ] ] ; # fhir:component ( [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "biomarker-category" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/molecular-biomarker-ontology-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "molgen" ] ; fhir:display [ fhir:v "molecular sequence adjacent category" ] ] ) ] ] ) . # <urn:uuid:64b91716-6431-41bd-8fd4-7ac99bebdee9> a fhir:Observation ; fhir:id [ fhir:v "Inline-Instance-for-oncologyexamples-r4-withGrouping-5"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-biomarker"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-biomarker> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-oncologyexamples-r4-withGrouping-5\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-withGrouping-5</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-5\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-5\"> </a><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-5-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs biomarker-category}\">A characterization of a given biomarker observation.</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81695-9}\">Microsatellite instability [Interpretation] in Cancer specimen Qualitative</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Bundle: type = transaction</a></p><p><b>effective</b>: 2023-05-01</p><p><b>performer</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Bundle: type = transaction</a></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA14122-8}\">Stable</span></p><p><b>specimen</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a5d6a6a9-4859-480e-85b2-56974fef3b9d\">Bundle: type = transaction</a></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs biomarker-category}\">A characterization of a given biomarker observation.</span></td><td><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/molecular-biomarker-ontology-cs molgen}\">molecular sequence adjacent category</span></td></tr></table></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "biomarker-category" ] ] ) ] [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0074"^^xsd:anyURI ] ; fhir:code [ fhir:v "GE" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:81695-9 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "81695-9" ] ; fhir:display [ fhir:v "Microsatellite instability [Interpretation] in Cancer specimen Qualitative" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ] ; # fhir:effective [ fhir:v "2023-05-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ) ; # fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA14122-8 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA14122-8" ] ; fhir:display [ fhir:v "Stable" ] ] ) ] ; # fhir:specimen [ fhir:reference [ fhir:v "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d" ] ] ; # fhir:component ( [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "biomarker-category" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/molecular-biomarker-ontology-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "molgen" ] ; fhir:display [ fhir:v "molecular sequence adjacent category" ] ] ) ] ] ) . # <urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12d> a fhir:Observation ; fhir:id [ fhir:v "Inline-Instance-for-oncologyexamples-r4-withGrouping-6"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-oncologyexamples-r4-withGrouping-6\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-withGrouping-6</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-6\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-6\"> </a><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-6-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Bundle: type = transaction</a></p><p><b>effective</b>: 2023-05-01</p><p><b>performer</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Bundle: type = transaction</a></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26398-0}\">Sequencing</span></p><p><b>specimen</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a5d6a6a9-4859-480e-85b2-56974fef3b9d\">Bundle: type = transaction</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81290-9}\">Genomic DNA change (gHGVS)</span></p><p><b>value</b>: <span title=\"Codes:{http://varnomen.hgvs.org NC_000009.12:g.5073770G>T}\">NC_000009.12:g.5073770G>T</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48005-3}\">Amino acid change (pHGVS)</span></p><p><b>value</b>: <span title=\"Codes:{http://varnomen.hgvs.org NP_004963.1:p.Val617Phe}\">NP_004963.1:p.Val617Phe</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48002-0}\">Genomic source class</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6683-2}\">Germline</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied ID</span></p><p><b>value</b>: <span title=\"Codes:\">JAK2</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0074"^^xsd:anyURI ] ; fhir:code [ fhir:v "GE" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:69548-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "69548-6" ] ; fhir:display [ fhir:v "Genetic variant assessment" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ] ; # fhir:effective [ fhir:v "2023-05-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ) ; # fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9633-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9633-4" ] ; fhir:display [ fhir:v "Present" ] ] ) ] ; # fhir:method [ ( fhir:coding [ a loinc:LA26398-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26398-0" ] ; fhir:display [ fhir:v "Sequencing" ] ] ) ] ; # fhir:specimen [ fhir:reference [ fhir:v "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d" ] ] ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:81290-9 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "81290-9" ] ; fhir:display [ fhir:v "Genomic DNA change (gHGVS)" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://varnomen.hgvs.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "NC_000009.12:g.5073770G>T" ] ; fhir:display [ fhir:v "NC_000009.12:g.5073770G>T" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48005-3 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48005-3" ] ; fhir:display [ fhir:v "Amino acid change (pHGVS)" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://varnomen.hgvs.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "NP_004963.1:p.Val617Phe" ] ; fhir:display [ fhir:v "NP_004963.1:p.Val617Phe" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48002-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48002-0" ] ; fhir:display [ fhir:v "Genomic source class" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA6683-2 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA6683-2" ] ; fhir:display [ fhir:v "Germline" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ; fhir:display [ fhir:v "Gene studied ID" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:display [ fhir:v "JAK2" ] ] ) ] ] ) . # <urn:uuid:772de7d7-e1bd-4183-bdb5-cea8eda317cd> a fhir:Observation ; fhir:id [ fhir:v "Inline-Instance-for-oncologyexamples-r4-withGrouping-7"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-oncologyexamples-r4-withGrouping-7\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-withGrouping-7</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-7\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-7\"> </a><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-7-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Bundle: type = transaction</a></p><p><b>effective</b>: 2023-05-01</p><p><b>performer</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Bundle: type = transaction</a></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26398-0}\">Sequencing</span></p><p><b>specimen</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a5d6a6a9-4859-480e-85b2-56974fef3b9d\">Bundle: type = transaction</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81290-9}\">Genomic DNA change (gHGVS)</span></p><p><b>value</b>: <span title=\"Codes:{http://varnomen.hgvs.org NC_000004.11:g.55972974T>A}\">NC_000004.11:g.55972974T>A</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48005-3}\">Amino acid change (pHGVS)</span></p><p><b>value</b>: <span title=\"Codes:{http://varnomen.hgvs.org NP_002244.1:p.Gln472His}\">NP_002244.1:p.Gln472His</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48002-0}\">Genomic source class</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6683-2}\">Germline</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied ID</span></p><p><b>value</b>: <span title=\"Codes:\">KDR</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0074"^^xsd:anyURI ] ; fhir:code [ fhir:v "GE" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:69548-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "69548-6" ] ; fhir:display [ fhir:v "Genetic variant assessment" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ] ; # fhir:effective [ fhir:v "2023-05-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ) ; # fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9633-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9633-4" ] ; fhir:display [ fhir:v "Present" ] ] ) ] ; # fhir:method [ ( fhir:coding [ a loinc:LA26398-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26398-0" ] ; fhir:display [ fhir:v "Sequencing" ] ] ) ] ; # fhir:specimen [ fhir:reference [ fhir:v "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d" ] ] ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:81290-9 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "81290-9" ] ; fhir:display [ fhir:v "Genomic DNA change (gHGVS)" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://varnomen.hgvs.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "NC_000004.11:g.55972974T>A" ] ; fhir:display [ fhir:v "NC_000004.11:g.55972974T>A" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48005-3 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48005-3" ] ; fhir:display [ fhir:v "Amino acid change (pHGVS)" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://varnomen.hgvs.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "NP_002244.1:p.Gln472His" ] ; fhir:display [ fhir:v "NP_002244.1:p.Gln472His" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48002-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48002-0" ] ; fhir:display [ fhir:v "Genomic source class" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA6683-2 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA6683-2" ] ; fhir:display [ fhir:v "Germline" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ; fhir:display [ fhir:v "Gene studied ID" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:display [ fhir:v "KDR" ] ] ) ] ] ) . # <urn:uuid:b33eb7ec-d83e-49d2-b0f3-729d024ebe01> a fhir:Observation ; fhir:id [ fhir:v "Inline-Instance-for-oncologyexamples-r4-withGrouping-8"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-oncologyexamples-r4-withGrouping-8\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-withGrouping-8</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-8\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-8\"> </a><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-8-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Bundle: type = transaction</a></p><p><b>effective</b>: 2023-05-01</p><p><b>performer</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Bundle: type = transaction</a></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26398-0}\">Sequencing</span></p><p><b>specimen</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a5d6a6a9-4859-480e-85b2-56974fef3b9d\">Bundle: type = transaction</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81290-9}\">Genomic DNA change (gHGVS)</span></p><p><b>value</b>: <span title=\"Codes:{http://varnomen.hgvs.org NC_000002.12:g.211713666_211713668del}\">NC_000002.12:g.211713666_211713668del</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48002-0}\">Genomic source class</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6683-2}\">Germline</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied ID</span></p><p><b>value</b>: <span title=\"Codes:\">ERBB4</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0074"^^xsd:anyURI ] ; fhir:code [ fhir:v "GE" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:69548-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "69548-6" ] ; fhir:display [ fhir:v "Genetic variant assessment" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ] ; # fhir:effective [ fhir:v "2023-05-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ) ; # fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9633-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9633-4" ] ; fhir:display [ fhir:v "Present" ] ] ) ] ; # fhir:method [ ( fhir:coding [ a loinc:LA26398-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26398-0" ] ; fhir:display [ fhir:v "Sequencing" ] ] ) ] ; # fhir:specimen [ fhir:reference [ fhir:v "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d" ] ] ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:81290-9 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "81290-9" ] ; fhir:display [ fhir:v "Genomic DNA change (gHGVS)" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://varnomen.hgvs.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "NC_000002.12:g.211713666_211713668del" ] ; fhir:display [ fhir:v "NC_000002.12:g.211713666_211713668del" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48002-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48002-0" ] ; fhir:display [ fhir:v "Genomic source class" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA6683-2 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA6683-2" ] ; fhir:display [ fhir:v "Germline" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ; fhir:display [ fhir:v "Gene studied ID" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:display [ fhir:v "ERBB4" ] ] ) ] ] ) . # <urn:uuid:1bf9642d-fd1c-4819-8c5d-44fae4bad524> a fhir:Observation ; fhir:id [ fhir:v "Inline-Instance-for-oncologyexamples-r4-withGrouping-9"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "extensions" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-oncologyexamples-r4-withGrouping-9\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-withGrouping-9</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-9\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-9\"> </a><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-9-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Bundle: type = transaction</a></p><p><b>effective</b>: 2023-05-01</p><p><b>performer</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Bundle: type = transaction</a></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26811-2}\">Computational analysis</span></p><p><b>specimen</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a5d6a6a9-4859-480e-85b2-56974fef3b9d\">Bundle: type = transaction</a></p><p><b>derivedFrom</b>: <a href=\"Bundle-bundle-complexVariant-nonHGVS.html#urn-uuid-16fdd5fc-e665-48af-99e4-48d603f3e12d\">Bundle: type = transaction</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6677-4}\">Responsive</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 93044-6}\">Level of evidence</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA30200-2}\">Very strong evidence pathogenic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81259-4}\">Associated phenotype</span></p><p><b>value</b>: <span title=\"Codes:\">Polycythemia vera (PV)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>Medication Assessed reference to a FHIR resource</b>: <a href=\"#hcInline-Instance-for-oncologyexamples-r4-withGrouping-9/Inline-MedicationKnowledgeRuxolitinib\">MedicationKnowledge Ruxolitinib</a></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 51963-7}\">Medication assessed [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.nlm.nih.gov/research/umls/rxnorm 1193326}\">Ruxolitinib</span></p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: MedicationKnowledge #Inline-MedicationKnowledgeRuxolitinib</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-9/Inline-MedicationKnowledgeRuxolitinib\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-9/Inline-MedicationKnowledgeRuxolitinib\"> </a><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-9/Inline-MedicationKnowledgeRuxolitinib-en-US\"> </a><p><b>code</b>: <span title=\"Codes:{http://www.nlm.nih.gov/research/umls/rxnorm 1193326}\">Ruxolitinib</span></p><p><b>status</b>: Active</p></blockquote></div>" ] ; # fhir:contained ( [ a fhir:MedicationKnowledge ; fhir:id [ fhir:v "Inline-MedicationKnowledgeRuxolitinib" ] ; fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://www.nlm.nih.gov/research/umls/rxnorm"^^xsd:anyURI ] ; fhir:code [ fhir:v "1193326" ] ; fhir:display [ fhir:v "Ruxolitinib" ] ] ) ] ; fhir:status [ fhir:v "active" ] ] ) ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0074"^^xsd:anyURI ] ; fhir:code [ fhir:v "GE" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "therapeutic-implication" ] ; fhir:display [ fhir:v "Therapeutic Implication" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ] ; # fhir:effective [ fhir:v "2023-05-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ) ; # fhir:method [ ( fhir:coding [ a loinc:LA26811-2 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26811-2" ] ; fhir:display [ fhir:v "Computational analysis" ] ] ) ] ; # fhir:specimen [ fhir:reference [ fhir:v "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d" ] ] ; # fhir:derivedFrom ( [ fhir:reference [ fhir:v "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12d" ] ] ) ; # fhir:component ( [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "therapeutic-implication" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA6677-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA6677-4" ] ; fhir:display [ fhir:v "Responsive" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:93044-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "93044-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA30200-2 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA30200-2" ] ; fhir:display [ fhir:v "Very strong evidence pathogenic" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:81259-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "81259-4" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; fhir:text [ fhir:v "Polycythemia vera (PV)" ] ] ] [ ( fhir:extension [ fhir:url [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/medication-assessed-reference"^^xsd:anyURI ] ; fhir:value [ a fhir:Reference ; fhir:reference [ fhir:v "#Inline-MedicationKnowledgeRuxolitinib" ] ] ] ) ; fhir:code [ ( fhir:coding [ a loinc:51963-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "51963-7" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.nlm.nih.gov/research/umls/rxnorm"^^xsd:anyURI ] ; fhir:code [ fhir:v "1193326" ] ; fhir:display [ fhir:v "Ruxolitinib" ] ] ) ] ] ) . # <urn:uuid:1301943b-55db-4adf-8355-3635f7268a1b> a fhir:Observation ; fhir:id [ fhir:v "Inline-Instance-for-oncologyexamples-r4-withGrouping-10"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-oncologyexamples-r4-withGrouping-10\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-withGrouping-10</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-10\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-10\"> </a><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-10-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Bundle: type = transaction</a></p><p><b>effective</b>: 2023-05-01</p><p><b>performer</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Bundle: type = transaction</a></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26811-2}\">Computational analysis</span></p><p><b>specimen</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a5d6a6a9-4859-480e-85b2-56974fef3b9d\">Bundle: type = transaction</a></p><p><b>derivedFrom</b>: <a href=\"Bundle-bundle-complexVariant-nonHGVS.html#urn-uuid-16fdd5fc-e665-48af-99e4-48d603f3e12d\">Bundle: type = transaction</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6677-4}\">Responsive</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 93044-6}\">Level of Evidence</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA30200-2}\">Very strong evidence pathogenic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81259-4}\">Associated phenotype</span></p><p><b>value</b>: <span title=\"Codes:\">Polycythemia vera (PV)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 51963-7}\">Medication assessed</span></p><p><b>value</b>: <span title=\"Codes:\">AT9283</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0074"^^xsd:anyURI ] ; fhir:code [ fhir:v "GE" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "therapeutic-implication" ] ; fhir:display [ fhir:v "Therapeutic Implication" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ] ; # fhir:effective [ fhir:v "2023-05-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ) ; # fhir:method [ ( fhir:coding [ a loinc:LA26811-2 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26811-2" ] ; fhir:display [ fhir:v "Computational analysis" ] ] ) ] ; # fhir:specimen [ fhir:reference [ fhir:v "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d" ] ] ; # fhir:derivedFrom ( [ fhir:reference [ fhir:v "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12d" ] ] ) ; # fhir:component ( [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "therapeutic-implication" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA6677-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA6677-4" ] ; fhir:display [ fhir:v "Responsive" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:93044-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "93044-6" ] ; fhir:display [ fhir:v "Level of Evidence" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA30200-2 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA30200-2" ] ; fhir:display [ fhir:v "Very strong evidence pathogenic" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:81259-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "81259-4" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; fhir:text [ fhir:v "Polycythemia vera (PV)" ] ] ] [ fhir:code [ ( fhir:coding [ a loinc:51963-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "51963-7" ] ; fhir:display [ fhir:v "Medication assessed" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; fhir:text [ fhir:v "AT9283" ] ] ] ) . # <urn:uuid:05713d1c-0df5-46d5-a5a9-2085eef56c20> a fhir:Observation ; fhir:id [ fhir:v "Inline-Instance-for-oncologyexamples-r4-withGrouping-11"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-oncologyexamples-r4-withGrouping-11\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-withGrouping-11</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-11\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-11\"> </a><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-11-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Bundle: type = transaction</a></p><p><b>effective</b>: 2023-05-01</p><p><b>performer</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Bundle: type = transaction</a></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26811-2}\">Computational analysis</span></p><p><b>specimen</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a5d6a6a9-4859-480e-85b2-56974fef3b9d\">Bundle: type = transaction</a></p><p><b>derivedFrom</b>: <a href=\"Bundle-bundle-complexVariant-nonHGVS.html#urn-uuid-16fdd5fc-e665-48af-99e4-48d603f3e12d\">Bundle: type = transaction</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6677-4}\">Responsive</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 93044-6}\">Level of Evidence</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA30200-2}\">Very strong evidence pathogenic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81259-4}\">Associated phenotype</span></p><p><b>value</b>: <span title=\"Codes:\">Polycythemia vera (PV)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 51963-7}\">Medication assessed</span></p><p><b>value</b>: <span title=\"Codes:\">SNX-5422</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0074"^^xsd:anyURI ] ; fhir:code [ fhir:v "GE" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "therapeutic-implication" ] ; fhir:display [ fhir:v "Therapeutic Implication" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ] ; # fhir:effective [ fhir:v "2023-05-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ) ; # fhir:method [ ( fhir:coding [ a loinc:LA26811-2 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26811-2" ] ; fhir:display [ fhir:v "Computational analysis" ] ] ) ] ; # fhir:specimen [ fhir:reference [ fhir:v "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d" ] ] ; # fhir:derivedFrom ( [ fhir:reference [ fhir:v "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12d" ] ] ) ; # fhir:component ( [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "therapeutic-implication" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA6677-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA6677-4" ] ; fhir:display [ fhir:v "Responsive" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:93044-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "93044-6" ] ; fhir:display [ fhir:v "Level of Evidence" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA30200-2 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA30200-2" ] ; fhir:display [ fhir:v "Very strong evidence pathogenic" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:81259-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "81259-4" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; fhir:text [ fhir:v "Polycythemia vera (PV)" ] ] ] [ fhir:code [ ( fhir:coding [ a loinc:51963-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "51963-7" ] ; fhir:display [ fhir:v "Medication assessed" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; fhir:text [ fhir:v "SNX-5422" ] ] ] ) . # <urn:uuid:294f1401-e2eb-4df1-b6d2-09e1b7a6eca4> a fhir:Observation ; fhir:id [ fhir:v "Inline-Instance-for-oncologyexamples-r4-withGrouping-12"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-oncologyexamples-r4-withGrouping-12\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-withGrouping-12</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-12\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-12\"> </a><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-12-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Bundle: type = transaction</a></p><p><b>effective</b>: 2023-05-01</p><p><b>performer</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Bundle: type = transaction</a></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26811-2}\">Computational analysis</span></p><p><b>specimen</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a5d6a6a9-4859-480e-85b2-56974fef3b9d\">Bundle: type = transaction</a></p><p><b>derivedFrom</b>: <a href=\"Bundle-bundle-complexVariant-nonHGVS.html#urn-uuid-16fdd5fc-e665-48af-99e4-48d603f3e12d\">Bundle: type = transaction</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6677-4}\">Responsive</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 93044-6}\">Level of Evidence</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA30200-2}\">Very strong evidence pathogenic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81259-4}\">Associated phenotype</span></p><p><b>value</b>: <span title=\"Codes:\">Polycythemia vera (PV)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 51963-7}\">Medication assessed</span></p><p><b>value</b>: <span title=\"Codes:\">TG02</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0074"^^xsd:anyURI ] ; fhir:code [ fhir:v "GE" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "therapeutic-implication" ] ; fhir:display [ fhir:v "Therapeutic Implication" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ] ; # fhir:effective [ fhir:v "2023-05-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ) ; # fhir:method [ ( fhir:coding [ a loinc:LA26811-2 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26811-2" ] ; fhir:display [ fhir:v "Computational analysis" ] ] ) ] ; # fhir:specimen [ fhir:reference [ fhir:v "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d" ] ] ; # fhir:derivedFrom ( [ fhir:reference [ fhir:v "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12d" ] ] ) ; # fhir:component ( [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "therapeutic-implication" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA6677-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA6677-4" ] ; fhir:display [ fhir:v "Responsive" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:93044-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "93044-6" ] ; fhir:display [ fhir:v "Level of Evidence" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA30200-2 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA30200-2" ] ; fhir:display [ fhir:v "Very strong evidence pathogenic" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:81259-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "81259-4" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; fhir:text [ fhir:v "Polycythemia vera (PV)" ] ] ] [ fhir:code [ ( fhir:coding [ a loinc:51963-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "51963-7" ] ; fhir:display [ fhir:v "Medication assessed" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; fhir:text [ fhir:v "TG02" ] ] ] ) . # <urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12f> a fhir:Observation ; fhir:id [ fhir:v "Inline-Instance-for-oncologyexamples-r4-withGrouping-13"] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-oncologyexamples-r4-withGrouping-13\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-withGrouping-13</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-13\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-13\"> </a><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-13-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C43359}\">Group</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Bundle: type = transaction</a></p><p><b>effective</b>: 2023-05-01</p><p><b>performer</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Bundle: type = transaction</a></p><p><b>hasMember</b>: </p><ul><li><a href=\"Bundle-bundle-complexVariant-nonHGVS.html#urn-uuid-16fdd5fc-e665-48af-99e4-48d603f3e12d\">SNV analysis for JAK2 variant</a></li><li><a href=\"Bundle-bundle-oncologyexamples-r4-withGrouping.html#urn-uuid-772de7d7-e1bd-4183-bdb5-cea8eda317cd\">SNV analysis for KDR variant</a></li><li><a href=\"Bundle-bundle-oncologyexamples-r4-withGrouping.html#urn-uuid-b33eb7ec-d83e-49d2-b0f3-729d024ebe01\">SNV analysis for ERBB4 variant</a></li><li><a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-40e85eda-4d31-4bd2-a5a0-c39d63f9824f\">TMB value analysis</a></li><li><a href=\"Bundle-bundle-oncologyexamples-r4-withGrouping.html#urn-uuid-64b91716-6431-41bd-8fd4-7ac99bebdee9\">MSI status analysis</a></li></ul></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0074"^^xsd:anyURI ] ; fhir:code [ fhir:v "GE" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C43359" ] ; fhir:display [ fhir:v "Group" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ] ; # fhir:effective [ fhir:v "2023-05-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ) ; # fhir:hasMember ( [ fhir:reference [ fhir:v "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12d" ] ; fhir:display [ fhir:v "SNV analysis for JAK2 variant" ] ] [ fhir:reference [ fhir:v "urn:uuid:772de7d7-e1bd-4183-bdb5-cea8eda317cd" ] ; fhir:display [ fhir:v "SNV analysis for KDR variant" ] ] [ fhir:reference [ fhir:v "urn:uuid:b33eb7ec-d83e-49d2-b0f3-729d024ebe01" ] ; fhir:display [ fhir:v "SNV analysis for ERBB4 variant" ] ] [ fhir:reference [ fhir:v "urn:uuid:40e85eda-4d31-4bd2-a5a0-c39d63f9824f" ] ; fhir:display [ fhir:v "TMB value analysis" ] ] [ fhir:reference [ fhir:v "urn:uuid:64b91716-6431-41bd-8fd4-7ac99bebdee9" ] ; fhir:display [ fhir:v "MSI status analysis" ] ] ) . # <urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12e> a fhir:Observation ; fhir:id [ fhir:v "Inline-Instance-for-oncologyexamples-r4-withGrouping-14"] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-oncologyexamples-r4-withGrouping-14\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-withGrouping-14</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-14\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-14\"> </a><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-14-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C43359}\">Group</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Bundle: type = transaction</a></p><p><b>effective</b>: 2023-05-01</p><p><b>performer</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Bundle: type = transaction</a></p><p><b>hasMember</b>: </p><ul><li><a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-1bf9642d-fd1c-4819-8c5d-44fae4bad524\">Therapy match result 1</a></li><li><a href=\"Bundle-bundle-oncologyexamples-r4-withGrouping.html#urn-uuid-1301943b-55db-4adf-8355-3635f7268a1b\">Therapy match result 2</a></li><li><a href=\"Bundle-bundle-oncologyexamples-r4-withGrouping.html#urn-uuid-05713d1c-0df5-46d5-a5a9-2085eef56c20\">Therapy match result 3</a></li><li><a href=\"Bundle-bundle-oncologyexamples-r4-withGrouping.html#urn-uuid-294f1401-e2eb-4df1-b6d2-09e1b7a6eca4\">Therapy match result 4</a></li></ul></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0074"^^xsd:anyURI ] ; fhir:code [ fhir:v "GE" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C43359" ] ; fhir:display [ fhir:v "Group" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ] ; # fhir:effective [ fhir:v "2023-05-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ) ; # fhir:hasMember ( [ fhir:reference [ fhir:v "urn:uuid:1bf9642d-fd1c-4819-8c5d-44fae4bad524" ] ; fhir:display [ fhir:v "Therapy match result 1" ] ] [ fhir:reference [ fhir:v "urn:uuid:1301943b-55db-4adf-8355-3635f7268a1b" ] ; fhir:display [ fhir:v "Therapy match result 2" ] ] [ fhir:reference [ fhir:v "urn:uuid:05713d1c-0df5-46d5-a5a9-2085eef56c20" ] ; fhir:display [ fhir:v "Therapy match result 3" ] ] [ fhir:reference [ fhir:v "urn:uuid:294f1401-e2eb-4df1-b6d2-09e1b7a6eca4" ] ; fhir:display [ fhir:v "Therapy match result 4" ] ] ) . # <urn:uuid:ad7a499b-a43b-4cc8-bf46-cac62d9ecae5> a fhir:DiagnosticReport ; fhir:id [ fhir:v "Inline-Instance-for-oncologyexamples-r4-withGrouping-15"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-report"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-report> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"DiagnosticReport_Inline-Instance-for-oncologyexamples-r4-withGrouping-15\"> </a><p class=\"res-header-id\"><b>Generated Narrative: DiagnosticReport Inline-Instance-for-oncologyexamples-r4-withGrouping-15</b></p><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-15\"> </a><a name=\"hcInline-Instance-for-oncologyexamples-r4-withGrouping-15\"> </a><a name=\"Inline-Instance-for-oncologyexamples-r4-withGrouping-15-en-US\"> </a><h2><span title=\"Codes:{http://loinc.org 51969-4}\">Genetic analysis report</span> (<span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>) </h2><table class=\"grid\"><tr><td>Subject</td><td>Not done yet</td></tr><tr><td>Performer</td><td> <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Bundle: type = transaction</a></td></tr></table><p><b>Report Details</b></p><table class=\"grid\"><tr><td><b>Code</b></td><td><b>Value</b></td></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr></table></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0074"^^xsd:anyURI ] ; fhir:code [ fhir:v "GE" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:51969-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "51969-4" ] ] ) ; fhir:text [ fhir:v "Genetic analysis report" ] ] ; # fhir:subject [ fhir:reference [ fhir:v "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d" ] ] ; # fhir:performer ( [ fhir:reference [ fhir:v "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef" ] ] ) ; # fhir:specimen ( [ fhir:reference [ fhir:v "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d" ] ] ) ; # fhir:result ( [ fhir:reference [ fhir:v "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12f" ] ; fhir:display [ fhir:v "Variants and other biomarker tests" ] ] [ fhir:reference [ fhir:v "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12d" ] ; fhir:display [ fhir:v "SNV analysis for JAK2 variant" ] ] [ fhir:reference [ fhir:v "urn:uuid:772de7d7-e1bd-4183-bdb5-cea8eda317cd" ] ; fhir:display [ fhir:v "SNV analysis for KDR variant" ] ] [ fhir:reference [ fhir:v "urn:uuid:b33eb7ec-d83e-49d2-b0f3-729d024ebe01" ] ; fhir:display [ fhir:v "SNV analysis for ERBB4 variant" ] ] [ fhir:reference [ fhir:v "urn:uuid:40e85eda-4d31-4bd2-a5a0-c39d63f9824f" ] ; fhir:display [ fhir:v "TMB value analysis" ] ] [ fhir:reference [ fhir:v "urn:uuid:64b91716-6431-41bd-8fd4-7ac99bebdee9" ] ; fhir:display [ fhir:v "MSI status analysis" ] ] [ fhir:reference [ fhir:v "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12e" ] ; fhir:display [ fhir:v "Therapy Match Results" ] ] [ fhir:reference [ fhir:v "urn:uuid:1bf9642d-fd1c-4819-8c5d-44fae4bad524" ] ; fhir:display [ fhir:v "Therapy match result 1" ] ] [ fhir:reference [ fhir:v "urn:uuid:1301943b-55db-4adf-8355-3635f7268a1b" ] ; fhir:display [ fhir:v "Therapy match result 2" ] ] [ fhir:reference [ fhir:v "urn:uuid:05713d1c-0df5-46d5-a5a9-2085eef56c20" ] ; fhir:display [ fhir:v "Therapy match result 3" ] ] [ fhir:reference [ fhir:v "urn:uuid:294f1401-e2eb-4df1-b6d2-09e1b7a6eca4" ] ; fhir:display [ fhir:v "Therapy match result 4" ] ] ) . #
IG © 2022+ HL7 International / Clinical Genomics. Package hl7.fhir.uv.genomics-reporting#3.0.0 based on FHIR 4.0.1. Generated 2024-12-12
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